locus-tag	class	description
Tmath_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Tmath_0002	COG0592	DNA-directed DNA polymerase activity
Tmath_0003	COG2501	S4 domain
Tmath_0007	COG3442	glutamine amidotransferase
Tmath_0009	COG0187	DNA topoisomerase II activity
Tmath_0010	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Tmath_0014	COG3464	Transposase
Tmath_0021	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Tmath_0022	COG1518	maintenance of DNA repeat elements
Tmath_0024	COG1203	CRISPR-associated helicase, Cas3
Tmath_0029	COG1902	pentaerythritol trinitrate reductase activity
Tmath_0030	COG0440	acetolactate synthase activity
Tmath_0032	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Tmath_0034	COG0066	3-isopropylmalate dehydratase activity
Tmath_0035	COG0473	3-isopropylmalate dehydrogenase activity
Tmath_0036	COG0129	dihydroxy-acid dehydratase activity
Tmath_0037	COG0028	Belongs to the TPP enzyme family
Tmath_0042	COG0628	permease
Tmath_0045	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Tmath_0046	COG1316	TRANSCRIPTIONal
Tmath_0047	COG1615	UPF0182 protein
Tmath_0048	COG0582	viral genome integration into host DNA
Tmath_0051	COG1396	sequence-specific DNA binding
Tmath_0052	COG3620	sequence-specific DNA binding
Tmath_0061	COG2894	cell division
Tmath_0062	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
Tmath_0084	COG0739	heme binding
Tmath_0096	COG1598	PFAM Uncharacterised protein family UPF0150
Tmath_0099	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Tmath_0099	COG2199	diguanylate cyclase activity
Tmath_0100	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Tmath_0101	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Tmath_0102	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Tmath_0103	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Tmath_0104	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Tmath_0105	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Tmath_0109	COG1028	Short-chain dehydrogenase reductase Sdr
Tmath_0110	COG1187	pseudouridine synthase activity
Tmath_0112	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Tmath_0113	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Tmath_0114	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Tmath_0117	COG1181	Belongs to the D-alanine--D-alanine ligase family
Tmath_0118	COG1028	Short-chain dehydrogenase reductase Sdr
Tmath_0120	COG1511	domain protein
Tmath_0123	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Tmath_0125	COG1573	uracil-dna glycosylase
Tmath_0135	COG2391	methyltransferase activity
Tmath_0137	COG2391	methyltransferase activity
Tmath_0139	COG1940	carbohydrate kinase activity
Tmath_0140	COG0519	Catalyzes the synthesis of GMP from XMP
Tmath_0142	COG1982	Orn Lys Arg decarboxylase major
Tmath_0143	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Tmath_0144	COG3870	Protein conserved in bacteria
Tmath_0146	COG0470	DNA polymerase III
Tmath_0147	COG1774	PSP1 C-terminal conserved region
Tmath_0148	COG2235	arginine
Tmath_0149	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Tmath_0150	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Tmath_0152	COG2002	toxin-antitoxin pair type II binding
Tmath_0153	COG2715	membrane protein required for spore maturation
Tmath_0154	COG0700	Nucleoside recognition
Tmath_0155	COG0617	tRNA 3'-terminal CCA addition
Tmath_0156	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tmath_0156	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tmath_0157	COG0084	hydrolase, TatD family'
Tmath_0158	COG3584	3D domain protein
Tmath_0158	COG3583	domain protein
Tmath_0159	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Tmath_0165	COG0489	protein tyrosine kinase activity
Tmath_0165	COG2151	metal-sulfur cluster biosynthetic enzyme
Tmath_0168	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Tmath_0169	COG4656	Part of a membrane complex involved in electron transport
Tmath_0170	COG4658	electron transport chain
Tmath_0171	COG4659	FMN binding
Tmath_0172	COG4660	Part of a membrane complex involved in electron transport
Tmath_0173	COG4657	Part of a membrane complex involved in electron transport
Tmath_0174	COG1245	4Fe-4S binding domain
Tmath_0174	COG2878	Part of a membrane complex involved in electron transport
Tmath_0178	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Tmath_0179	COG0254	rRNA binding
Tmath_0180	COG1435	thymidine kinase activity
Tmath_0181	COG3872	metal-dependent enzyme
Tmath_0183	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Tmath_0184	COG0428	transporter
Tmath_0185	COG0009	L-threonylcarbamoyladenylate synthase
Tmath_0186	COG0698	ribose 5-phosphate isomerase
Tmath_0187	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Tmath_0189	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Tmath_0190	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Tmath_0193	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Tmath_0194	COG0686	Belongs to the AlaDH PNT family
Tmath_0196	COG2385	sporulation resulting in formation of a cellular spore
Tmath_0198	COG1609	Transcriptional regulator
Tmath_0199	COG1077	Cell shape determining protein MreB Mrl
Tmath_0200	COG4786	Flagellar basal body rod
Tmath_0203	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Tmath_0210	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Tmath_0210	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Tmath_0212	COG3414	Phosphotransferase system galactitol-specific IIB component
Tmath_0213	COG3775	system Galactitol-specific IIC component
Tmath_0214	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Tmath_0217	COG4948	Mandelate Racemase Muconate Lactonizing
Tmath_0218	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Tmath_0219	COG0800	Aldolase
Tmath_0221	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Tmath_0221	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Tmath_0222	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tmath_0224	COG3716	PTS system mannose fructose sorbose family IID component
Tmath_0225	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Tmath_0226	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Tmath_0227	COG0800	Aldolase
Tmath_0228	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Tmath_0229	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Tmath_0230	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Tmath_0231	COG0569	domain protein
Tmath_0234	COG1070	Carbohydrate kinase
Tmath_0235	COG0673	inositol 2-dehydrogenase activity
Tmath_0237	COG1904	glucuronate isomerase
Tmath_0238	COG0800	Aldolase
Tmath_0239	COG0246	Mannitol dehydrogenase
Tmath_0240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Tmath_0242	COG4209	transmembrane transport
Tmath_0243	COG0395	ABC-type sugar transport system, permease component
Tmath_0246	COG3250	beta-galactosidase activity
Tmath_0250	COG3458	cephalosporin-C deacetylase activity
Tmath_0256	COG0395	ABC-type sugar transport system, permease component
Tmath_0260	COG1609	Transcriptional regulator
Tmath_0261	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Tmath_0262	COG1869	D-ribose catabolic process
Tmath_0263	COG1129	ABC transporter
Tmath_0264	COG1172	Belongs to the binding-protein-dependent transport system permease family
Tmath_0265	COG1879	ABC-type sugar transport system periplasmic component
Tmath_0266	COG1737	Transcriptional regulator
Tmath_0267	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
Tmath_0269	COG1175	transmembrane transport
Tmath_0270	COG0395	ABC-type sugar transport system, permease component
Tmath_0271	COG3842	ATPase activity
Tmath_0273	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Tmath_0274	COG3876	Protein conserved in bacteria
Tmath_0275	COG1472	Belongs to the glycosyl hydrolase 3 family
Tmath_0276	COG2971	BadF BadG BcrA BcrD
Tmath_0277	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Tmath_0278	COG0456	acetyltransferase
Tmath_0279	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Tmath_0281	COG1649	PFAM Uncharacterised BCR, COG1649
Tmath_0285	COG3464	Transposase
Tmath_0288	COG0436	Aminotransferase
Tmath_0289	COG1522	sequence-specific DNA binding
Tmath_0291	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Tmath_0291	COG1918	ferrous iron import across plasma membrane
Tmath_0292	COG3464	Transposase
Tmath_0294	COG1122	ATPase activity
Tmath_0295	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Tmath_0296	COG0310	cobalt ion transport
Tmath_0297	COG0310	cobalt ion transport
Tmath_0298	COG0864	Transcriptional regulator
Tmath_0300	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Tmath_0301	COG0534	Mate efflux family protein
Tmath_0302	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tmath_0303	COG1136	(ABC) transporter
Tmath_0304	COG1136	(ABC) transporter
Tmath_0304	COG0577	efflux transmembrane transporter activity
Tmath_0307	COG0179	Fumarylacetoacetate (FAA) hydrolase
Tmath_0308	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
Tmath_0309	COG1074	ATP-dependent DNA helicase activity
Tmath_0310	COG0420	3'-5' exonuclease activity
Tmath_0311	COG0419	ATPase involved in DNA repair
Tmath_0312	COG0450	alkyl hydroperoxide reductase
Tmath_0317	COG0297	glycogen (starch) synthase activity
Tmath_0318	COG0586	Pfam SNARE associated Golgi protein
Tmath_0320	COG0039	L-malate dehydrogenase activity
Tmath_0323	COG0493	'glutamate synthase
Tmath_0323	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Tmath_0326	COG3275	phosphorelay sensor kinase activity
Tmath_0327	COG2197	response regulator
Tmath_0328	COG4213	ABC transporter substrate-binding protein
Tmath_0329	COG4213	ABC transporter substrate-binding protein
Tmath_0331	COG4214	carbohydrate transport
Tmath_0332	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Tmath_0333	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Tmath_0335	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Tmath_0336	COG0095	Lipoate-protein ligase
Tmath_0337	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Tmath_0340	COG0436	Aminotransferase
Tmath_0341	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tmath_0341	COG3711	transcriptional antiterminator
Tmath_0342	COG3037	sugar-specific permease SgaT UlaA
Tmath_0345	COG3623	hexulose-6-phosphate isomerase
Tmath_0350	COG1979	alcohol dehydrogenase
Tmath_0353	COG1309	transcriptional regulator
Tmath_0356	COG1924	4 iron, 4 sulfur cluster binding
Tmath_0358	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Tmath_0359	COG0390	transport system, permease component
Tmath_0360	COG0495	leucyl-tRNA aminoacylation
Tmath_0361	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
Tmath_0363	COG1522	sequence-specific DNA binding
Tmath_0363	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Tmath_0364	COG2313	pseudouridylate synthase activity
Tmath_0366	COG0306	phosphate transporter
Tmath_0368	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Tmath_0368	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Tmath_0370	COG3394	polysaccharide catabolic process
Tmath_0372	COG1447	Phosphotransferase system cellobiose-specific component IIA
Tmath_0373	COG1486	melibiose metabolic process
Tmath_0374	COG2723	6-phospho-beta-galactosidase activity
Tmath_0375	COG2213	PTS system mannitol-specific
Tmath_0376	COG3711	transcriptional antiterminator
Tmath_0376	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tmath_0379	COG0737	Belongs to the 5'-nucleotidase family
Tmath_0380	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Tmath_0381	COG0730	response to heat
Tmath_0383	COG1609	Transcriptional regulator
Tmath_0384	COG4166	transmembrane transport
Tmath_0385	COG0601	transmembrane transport
Tmath_0386	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Tmath_0387	COG0444	Belongs to the ABC transporter superfamily
Tmath_0389	COG3250	beta-galactosidase activity
Tmath_0391	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Tmath_0392	COG1121	(ABC) transporter
Tmath_0393	COG0803	Belongs to the bacterial solute-binding protein 9 family
Tmath_0394	COG0735	belongs to the Fur family
Tmath_0395	COG1704	LemA family
Tmath_0396	COG0583	DNA-binding transcription factor activity
Tmath_0399	COG2221	Nitrite and sulphite reductase 4Fe-4S
Tmath_0400	COG0084	hydrolase, TatD family'
Tmath_0403	COG0822	iron-sulfur transferase activity
Tmath_0409	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Tmath_0410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Tmath_0411	COG1120	ATPase activity
Tmath_0412	COG1797	cobyrinic acid a,c-diamide synthase activity
Tmath_0417	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Tmath_0426	COG2875	Belongs to the precorrin methyltransferase family
Tmath_0430	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Tmath_0433	COG0113	porphobilinogen synthase activity
Tmath_0434	COG1648	precorrin-2 dehydrogenase activity
Tmath_0434	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Tmath_0437	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Tmath_0438	COG0310	cobalt ion transport
Tmath_0441	COG1122	ATPase activity
Tmath_0454	COG4555	ABC transporter
Tmath_0460	COG2814	Major facilitator Superfamily
Tmath_0468	COG1131	(ABC) transporter
Tmath_0470	COG4566	intracellular signal transduction
Tmath_0484	COG1131	(ABC) transporter
Tmath_0487	COG0778	Nitroreductase
Tmath_0489	COG4566	intracellular signal transduction
Tmath_0492	COG1136	(ABC) transporter
Tmath_0495	COG1363	Peptidase, m42
Tmath_0500	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Tmath_0500	COG2199	diguanylate cyclase activity
Tmath_0501	COG0840	transmembrane signaling receptor activity
Tmath_0508	COG1653	transport
Tmath_0509	COG2972	Histidine kinase
Tmath_0510	COG2207	Transcriptional regulator
Tmath_0510	COG4753	response regulator
Tmath_0511	COG3404	Formiminotransferase-cyclodeaminase
Tmath_0512	COG1744	ABC transporter substrate-binding protein PnrA-like
Tmath_0518	COG2188	Transcriptional regulator
Tmath_0520	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Tmath_0522	COG0840	transmembrane signaling receptor activity
Tmath_0524	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Tmath_0524	COG1263	PTS System
Tmath_0524	COG2190	(PTS) system
Tmath_0525	COG2190	(PTS) system
Tmath_0526	COG3711	transcriptional antiterminator
Tmath_0527	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Tmath_0535	COG2081	HI0933 family
Tmath_0536	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Tmath_0538	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Tmath_0540	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
Tmath_0542	COG2323	membrane
Tmath_0543	COG0561	phosphatase activity
Tmath_0544	COG1609	Transcriptional regulator
Tmath_0545	COG0745	RESPONSE REGULATOR receiver
Tmath_0546	COG5002	protein histidine kinase activity
Tmath_0551	COG1592	Rubrerythrin
Tmath_0552	COG2104	thiamine diphosphate biosynthetic process
Tmath_0553	COG0037	tRNA processing
Tmath_0554	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Tmath_0555	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Tmath_0556	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Tmath_0557	COG1040	competence protein
Tmath_0561	COG1256	bacterial-type flagellum assembly
Tmath_0561	COG4786	Flagellar basal body rod
Tmath_0562	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Tmath_0564	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
Tmath_0565	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Tmath_0569	COG0367	asparagine synthase
Tmath_0572	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Tmath_0573	COG1516	flagellar protein fliS
Tmath_0575	COG0840	transmembrane signaling receptor activity
Tmath_0577	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Tmath_0578	COG0765	amino acid transport
Tmath_0584	COG1827	regulation of RNA biosynthetic process
Tmath_0586	COG0653	protein targeting
Tmath_0588	COG2183	response to ionizing radiation
Tmath_0591	COG0398	Pfam SNARE associated Golgi protein
Tmath_0595	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Tmath_0598	COG0802	atpase or kinase
Tmath_0599	COG1214	PFAM Peptidase M22, glycoprotease
Tmath_0601	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Tmath_0603	COG0488	(ABC) transporter
Tmath_0604	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Tmath_0608	COG3279	Response regulator of the LytR AlgR family
Tmath_0609	COG3290	protein histidine kinase activity
Tmath_0614	COG0493	'glutamate synthase
Tmath_0617	COG1811	Na channel or pump
Tmath_0619	COG1404	Belongs to the peptidase S8 family
Tmath_0624	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Tmath_0625	COG0459	protein refolding
Tmath_0626	COG0516	GMP reductase activity
Tmath_0626	COG0517	IMP dehydrogenase activity
Tmath_0627	COG0519	Catalyzes the synthesis of GMP from XMP
Tmath_0627	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Tmath_0628	COG2252	PERMEase
Tmath_0629	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Tmath_0630	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Tmath_0631	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Tmath_0632	COG0047	phosphoribosylformylglycinamidine synthase activity
Tmath_0633	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Tmath_0634	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Tmath_0635	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Tmath_0636	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Tmath_0637	COG0138	bifunctional purine biosynthesis protein purh
Tmath_0638	COG0151	Belongs to the GarS family
Tmath_0640	COG1473	amidohydrolase
Tmath_0641	COG2244	polysaccharide biosynthetic process
Tmath_0643	COG3711	transcriptional antiterminator
Tmath_0645	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Tmath_0646	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Tmath_0647	COG1447	Phosphotransferase system cellobiose-specific component IIA
Tmath_0649	COG0210	DNA helicase
Tmath_0650	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Tmath_0651	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Tmath_0653	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Tmath_0655	COG0860	N-Acetylmuramoyl-L-alanine amidase
Tmath_0655	COG2247	cell wall binding repeat
Tmath_0656	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Tmath_0661	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Tmath_0661	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Tmath_0662	COG1447	Phosphotransferase system cellobiose-specific component IIA
Tmath_0664	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Tmath_0666	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Tmath_0667	COG0698	ribose 5-phosphate isomerase
Tmath_0668	COG2723	6-phospho-beta-galactosidase activity
Tmath_0670	COG0351	phosphomethylpyrimidine kinase
Tmath_0671	COG0352	thiamine-phosphate diphosphorylase activity
Tmath_0672	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
Tmath_0675	COG0704	Plays a role in the regulation of phosphate uptake
Tmath_0676	COG0410	ABC transporter
Tmath_0679	COG0559	Belongs to the binding-protein-dependent transport system permease family
Tmath_0685	COG0544	peptidyl-prolyl cis-trans isomerase activity
Tmath_0686	COG0740	serine-type endopeptidase activity
Tmath_0687	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Tmath_0688	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Tmath_0689	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Tmath_0691	COG0356	it plays a direct role in the translocation of protons across the membrane
Tmath_0692	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Tmath_0693	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Tmath_0694	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Tmath_0695	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Tmath_0696	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Tmath_0697	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Tmath_0698	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Tmath_0700	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Tmath_0700	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Tmath_0701	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Tmath_0702	COG1116	anion transmembrane transporter activity
Tmath_0706	COG2239	Acts as a magnesium transporter
Tmath_0711	COG0840	transmembrane signaling receptor activity
Tmath_0711	COG3290	protein histidine kinase activity
Tmath_0713	COG1086	Polysaccharide biosynthesis protein
Tmath_0714	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Tmath_0715	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Tmath_0716	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
Tmath_0718	COG2089	acid synthase
Tmath_0719	COG3980	spore coat polysaccharide biosynthesis protein
Tmath_0722	COG0438	transferase activity, transferring glycosyl groups
Tmath_0725	COG3944	biosynthesis protein
Tmath_0731	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Tmath_0733	COG0622	Phosphoesterase
Tmath_0735	COG1914	H( )-stimulated, divalent metal cation uptake system
Tmath_0737	COG1598	PFAM Uncharacterised protein family UPF0150
Tmath_0754	COG0667	Aldo Keto reductase
Tmath_0756	COG0656	L-ascorbic acid biosynthetic process
Tmath_0759	COG0789	Transcriptional regulator
Tmath_0761	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Tmath_0764	COG0250	Participates in transcription elongation, termination and antitermination
Tmath_0766	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Tmath_0767	COG3944	biosynthesis protein
Tmath_0768	COG3949	Membrane
Tmath_0770	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Tmath_0771	COG0105	UTP biosynthetic process
Tmath_0772	COG2814	Major facilitator Superfamily
Tmath_0777	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Tmath_0778	COG1606	tRNA processing
Tmath_0779	COG1691	(AIR) carboxylase
Tmath_0780	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Tmath_0781	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Tmath_0782	COG5002	protein histidine kinase activity
Tmath_0783	COG0745	RESPONSE REGULATOR receiver
Tmath_0787	COG0525	valine-tRNA ligase activity
Tmath_0789	COG0285	dihydrofolate synthase activity
Tmath_0794	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Tmath_0795	COG1609	Transcriptional regulator
Tmath_0798	COG1175	transmembrane transport
Tmath_0799	COG0395	ABC-type sugar transport system, permease component
Tmath_0800	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Tmath_0803	COG0395	ABC-type sugar transport system, permease component
Tmath_0806	COG1404	Belongs to the peptidase S8 family
Tmath_0808	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Tmath_0808	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Tmath_0809	COG3773	Cell wall hydrolase
Tmath_0809	COG3409	Peptidoglycan-binding domain 1 protein
Tmath_0814	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Tmath_0815	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Tmath_0816	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Tmath_0818	COG1132	(ABC) transporter
Tmath_0819	COG1132	(ABC) transporter
Tmath_0823	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Tmath_0824	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Tmath_0826	COG0739	heme binding
Tmath_0833	COG0616	signal peptide processing
Tmath_0837	COG4475	Protein of unknown function (DUF436)
Tmath_0841	COG1131	(ABC) transporter
Tmath_0847	COG1113	amino acid transport
Tmath_0848	COG1595	DNA-templated transcription, initiation
Tmath_0850	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Tmath_0850	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Tmath_0851	COG0237	dephospho-CoA kinase activity
Tmath_0854	COG4166	transmembrane transport
Tmath_0856	COG0791	NLP P60 protein
Tmath_0858	COG0741	lytic transglycosylase activity
Tmath_0862	COG2878	Part of a membrane complex involved in electron transport
Tmath_0866	COG4191	Histidine kinase
Tmath_0866	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Tmath_0871	COG0424	maF-like protein
Tmath_0872	COG2003	Belongs to the UPF0758 family
Tmath_0873	COG1077	Cell shape determining protein MreB Mrl
Tmath_0876	COG0768	penicillin binding
Tmath_0877	COG0850	regulation of cytokinetic process
Tmath_0878	COG2894	cell division
Tmath_0879	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Tmath_0880	COG0772	Belongs to the SEDS family
Tmath_0881	COG1803	Methylglyoxal synthase
Tmath_0882	COG0739	heme binding
Tmath_0883	COG1994	Peptidase M50
Tmath_0883	COG0517	IMP dehydrogenase activity
Tmath_0886	COG1530	ribonuclease E activity
Tmath_0887	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Tmath_0889	COG3464	Transposase
Tmath_0890	COG3464	Transposase
Tmath_0891	COG5416	Lipopolysaccharide assembly protein A domain
Tmath_0892	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Tmath_0894	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Tmath_0896	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Tmath_0898	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Tmath_0899	COG1713	HD superfamily hydrolase involved in NAD metabolism
Tmath_0900	COG1316	TRANSCRIPTIONal
Tmath_0901	COG0799	negative regulation of ribosome biogenesis
Tmath_0905	COG0367	asparagine synthase
Tmath_0906	COG1686	Belongs to the peptidase S11 family
Tmath_0907	COG1596	polysaccharide export
Tmath_0907	COG1555	photosystem II stabilization
Tmath_0909	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Tmath_0914	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Tmath_0917	COG4720	Psort location CytoplasmicMembrane, score
Tmath_0919	COG1234	tRNA 3'-trailer cleavage
Tmath_0920	COG2333	competence protein COMEC
Tmath_0920	COG0658	competence protein
Tmath_0922	COG0268	Binds directly to 16S ribosomal RNA
Tmath_0923	COG1297	OPT oligopeptide transporter protein
Tmath_0927	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Tmath_0932	COG0481	GTPase activity
Tmath_0933	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Tmath_0935	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Tmath_0937	COG0484	heat shock protein binding
Tmath_0939	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Tmath_0940	COG3830	Belongs to the UPF0237 family
Tmath_0943	COG0701	Predicted permease
Tmath_0947	COG0745	RESPONSE REGULATOR receiver
Tmath_0948	COG2770	Histidine kinase
Tmath_0948	COG2205	protein histidine kinase activity
Tmath_0949	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Tmath_0952	COG0463	Glycosyl transferase, family 2
Tmath_0954	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Tmath_0955	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tmath_0956	COG0537	adenosine 5'-monophosphoramidase activity
Tmath_0957	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Tmath_0961	COG1702	phosphate starvation-inducible protein PhoH
Tmath_0962	COG1480	7TM receptor with intracellular HD hydrolase
Tmath_0963	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Tmath_0964	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Tmath_0965	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Tmath_0966	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Tmath_0969	COG0423	glycine-tRNA ligase activity
Tmath_0971	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Tmath_0972	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Tmath_0972	COG0574	Belongs to the PEP-utilizing enzyme family
Tmath_0974	COG0557	exoribonuclease II activity
Tmath_0990	COG1132	(ABC) transporter
Tmath_0993	COG4555	ABC transporter
Tmath_1002	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
Tmath_1004	COG0693	protein deglycase activity
Tmath_1006	COG2267	carboxylic ester hydrolase activity
Tmath_1010	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Tmath_1011	COG1968	undecaprenyl-diphosphatase activity
Tmath_1014	COG3069	C4-dicarboxylate transmembrane transporter activity
Tmath_1016	COG0426	domain, Protein
Tmath_1017	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Tmath_1019	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Tmath_1020	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Tmath_1021	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Tmath_1024	COG1760	l-serine dehydratase
Tmath_1025	COG1164	Oligoendopeptidase f
Tmath_1027	COG0077	Prephenate dehydratase
Tmath_1027	COG1605	Chorismate mutase
Tmath_1028	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Tmath_1029	COG0287	Prephenate dehydrogenase
Tmath_1030	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Tmath_1032	COG3773	Cell wall hydrolase
Tmath_1032	COG3409	Peptidoglycan-binding domain 1 protein
Tmath_1033	COG2119	membrane
Tmath_1036	COG0745	RESPONSE REGULATOR receiver
Tmath_1037	COG2205	protein histidine kinase activity
Tmath_1040	COG1940	carbohydrate kinase activity
Tmath_1041	COG0363	glucosamine-6-phosphate deaminase activity
Tmath_1043	COG0785	Cytochrome C biogenesis protein
Tmath_1044	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Tmath_1045	COG1982	Orn Lys Arg decarboxylase major
Tmath_1050	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Tmath_1053	COG1739	Uncharacterized protein family UPF0029
Tmath_1057	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Tmath_1058	COG0217	transcriptional regulatory protein
Tmath_1059	COG0835	chemotaxis
Tmath_1061	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Tmath_1062	COG0632	four-way junction helicase activity
Tmath_1063	COG2255	four-way junction helicase activity
Tmath_1065	COG2247	cell wall binding repeat
Tmath_1065	COG2385	sporulation resulting in formation of a cellular spore
Tmath_1067	COG0343	queuine tRNA-ribosyltransferase activity
Tmath_1071	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Tmath_1072	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Tmath_1073	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Tmath_1074	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Tmath_1076	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Tmath_1076	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Tmath_1078	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Tmath_1079	COG1490	D-aminoacyl-tRNA deacylase activity
Tmath_1080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tmath_1081	COG0577	efflux transmembrane transporter activity
Tmath_1082	COG1136	(ABC) transporter
Tmath_1083	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tmath_1086	COG0124	histidyl-tRNA synthetase
Tmath_1087	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Tmath_1088	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Tmath_1089	COG1937	Protein conserved in bacteria
Tmath_1090	COG3118	belongs to the thioredoxin family
Tmath_1092	COG3457	Alanine racemase
Tmath_1093	COG1959	2 iron, 2 sulfur cluster binding
Tmath_1095	COG0628	permease
Tmath_1096	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Tmath_1097	COG4472	Bacterial protein of unknown function (DUF965)
Tmath_1098	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Tmath_1099	COG3906	Belongs to the UPF0473 family
Tmath_1100	COG0735	belongs to the Fur family
Tmath_1101	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Tmath_1102	COG3679	Belongs to the UPF0342 family
Tmath_1104	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Tmath_1107	COG0768	penicillin binding
Tmath_1108	COG1191	sigma factor activity
Tmath_1110	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Tmath_1115	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Tmath_1126	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Tmath_1127	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Tmath_1128	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Tmath_1129	COG0006	proline dipeptidase activity
Tmath_1130	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Tmath_1132	COG3854	ATPases associated with a variety of cellular activities
Tmath_1140	COG1302	Protein conserved in bacteria
Tmath_1141	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Tmath_1142	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Tmath_1143	COG1570	exodeoxyribonuclease VII activity
Tmath_1144	COG1722	exodeoxyribonuclease VII activity
Tmath_1147	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Tmath_1148	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Tmath_1149	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Tmath_1150	COG1438	arginine binding
Tmath_1151	COG0497	DNA recombination
Tmath_1152	COG0750	zinc metalloprotease
Tmath_1161	COG1379	DNA repair
Tmath_1162	COG1300	Membrane
Tmath_1163	COG4974	Belongs to the 'phage' integrase family
Tmath_1164	COG1686	Belongs to the peptidase S11 family
Tmath_1165	COG1366	Belongs to the anti-sigma-factor antagonist family
Tmath_1166	COG2172	sigma factor antagonist activity
Tmath_1168	COG3360	Dodecin
Tmath_1173	COG1994	Peptidase M50
Tmath_1174	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Tmath_1175	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Tmath_1176	COG4086	secreted protein
Tmath_1178	COG3874	Sporulation protein YtfJ
Tmath_1179	COG1686	Belongs to the peptidase S11 family
Tmath_1181	COG0445	tRNA wobble uridine modification
Tmath_1182	COG1187	pseudouridine synthase activity
Tmath_1184	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Tmath_1187	COG1388	LysM domain
Tmath_1187	COG1705	Flagellar rod assembly protein muramidase FlgJ
Tmath_1189	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Tmath_1194	COG0406	alpha-ribazole phosphatase activity
Tmath_1195	COG2081	HI0933 family
Tmath_1198	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Tmath_1200	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Tmath_1201	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Tmath_1202	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Tmath_1204	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Tmath_1206	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Tmath_1207	COG1923	regulation of RNA biosynthetic process
Tmath_1208	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Tmath_1209	COG0328	RNA-DNA hybrid ribonuclease activity
Tmath_1210	COG4974	Belongs to the 'phage' integrase family
Tmath_1211	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
Tmath_1212	COG0464	growth
Tmath_1213	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Tmath_1215	COG0613	PHP domain protein
Tmath_1216	COG2359	stage V sporulation protein S
Tmath_1217	COG1692	metallophosphoesterase
Tmath_1218	COG1418	mRNA catabolic process
Tmath_1219	COG2137	regulation of response to DNA damage stimulus
Tmath_1220	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Tmath_1221	COG1058	Belongs to the CinA family
Tmath_1221	COG1546	Belongs to the CinA family
Tmath_1222	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Tmath_1223	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tmath_1224	COG1674	ftsk spoiiie
Tmath_1226	COG0740	serine-type endopeptidase activity
Tmath_1227	COG0527	aspartate kinase activity
Tmath_1229	COG0756	dUTP diphosphatase activity
Tmath_1230	COG0612	Peptidase, M16
Tmath_1231	COG0726	polysaccharide deacetylase
Tmath_1232	COG1185	polyribonucleotide nucleotidyltransferase activity
Tmath_1233	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Tmath_1234	COG0196	riboflavin kinase activity
Tmath_1235	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Tmath_1236	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Tmath_1237	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Tmath_1238	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Tmath_1240	COG2740	Nucleic-acid-binding protein implicated in transcription termination
Tmath_1241	COG0195	Participates in both transcription termination and antitermination
Tmath_1243	COG2176	DNA-directed DNA polymerase activity
Tmath_1245	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Tmath_1246	COG0750	zinc metalloprotease
Tmath_1247	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Tmath_1248	COG4589	Belongs to the CDS family
Tmath_1249	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Tmath_1251	COG0233	cytoplasmic translational termination
Tmath_1252	COG0528	UMP kinase activity
Tmath_1253	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Tmath_1257	COG1191	sigma factor activity
Tmath_1258	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Tmath_1259	COG1776	CheC inhibitor of MCP methylation
Tmath_1260	COG0835	chemotaxis
Tmath_1261	COG0643	Histidine kinase
Tmath_1261	COG2198	Histidine kinase
Tmath_1262	COG2201	protein-glutamate methylesterase activity
Tmath_1264	COG0455	bacterial-type flagellum organization
Tmath_1265	COG1419	protein localization to endoplasmic reticulum
Tmath_1266	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Tmath_1267	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Tmath_1268	COG1684	flagellar biosynthetic protein fliR
Tmath_1269	COG1987	bacterial-type flagellum assembly
Tmath_1270	COG1338	Plays a role in the flagellum-specific transport system
Tmath_1272	COG2201	protein-glutamate methylesterase activity
Tmath_1273	COG1776	CheC inhibitor of MCP methylation
Tmath_1273	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Tmath_1274	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Tmath_1275	COG1580	Controls the rotational direction of flagella during chemotaxis
Tmath_1276	COG1582	Flagellar protein (FlbD)
Tmath_1279	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Tmath_1283	COG1157	protein secretion by the type III secretion system
Tmath_1285	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Tmath_1286	COG1766	The M ring may be actively involved in energy transduction
Tmath_1287	COG1677	Flagellar hook-basal body complex protein FliE
Tmath_1289	COG1815	bacterial-type flagellum-dependent cell motility
Tmath_1292	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Tmath_1293	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Tmath_1294	COG0758	DNA mediated transformation
Tmath_1295	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Tmath_1296	COG0792	nuclease activity
Tmath_1297	COG0180	Tryptophanyl-tRNA synthetase
Tmath_1298	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Tmath_1299	COG0606	chelatase, subunit chli
Tmath_1301	COG0335	large ribosomal subunit rRNA binding
Tmath_1302	COG0336	Belongs to the RNA methyltransferase TrmD family
Tmath_1303	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Tmath_1304	COG1837	Belongs to the UPF0109 family
Tmath_1305	COG0228	four-way junction DNA binding
Tmath_1306	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Tmath_1307	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
Tmath_1308	COG0552	protein localization to endoplasmic reticulum
Tmath_1311	COG2359	stage V sporulation protein S
Tmath_1313	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
Tmath_1314	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Tmath_1315	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Tmath_1318	COG0437	4 iron, 4 sulfur cluster binding
Tmath_1319	COG0069	glutamate synthase activity
Tmath_1319	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Tmath_1320	COG0067	glutamate synthase
Tmath_1321	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Tmath_1321	COG0519	Catalyzes the synthesis of GMP from XMP
Tmath_1323	COG0347	Belongs to the P(II) protein family
Tmath_1324	COG0004	ammonium transporteR
Tmath_1327	COG0571	ribonuclease III activity
Tmath_1328	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Tmath_1329	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Tmath_1330	COG1028	Short-chain dehydrogenase reductase Sdr
Tmath_1331	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Tmath_1332	COG2070	2-Nitropropane dioxygenase
Tmath_1333	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Tmath_1334	COG0416	fatty acid biosynthetic process
Tmath_1335	COG2030	dehydratase
Tmath_1336	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Tmath_1337	COG1399	metal-binding, possibly nucleic acid-binding protein
Tmath_1338	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Tmath_1339	COG0280	phosphate acetyltransferase
Tmath_1341	COG3314	Sporulation integral membrane protein YlbJ
Tmath_1343	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Tmath_1344	COG0742	ribosomal rna small subunit methyltransferase
Tmath_1347	COG1307	EDD domain protein, DegV family
Tmath_1348	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Tmath_1349	COG1461	Dihydroxyacetone kinase
Tmath_1350	COG1302	Protein conserved in bacteria
Tmath_1354	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Tmath_1355	COG1162	GTPase activity
Tmath_1356	COG2815	serine threonine protein kinase
Tmath_1356	COG0515	serine threonine protein kinase
Tmath_1357	COG0631	protein serine/threonine phosphatase activity
Tmath_1358	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Tmath_1359	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Tmath_1359	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Tmath_1360	COG2738	Putative neutral zinc metallopeptidase
Tmath_1362	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Tmath_1363	COG0242	peptide deformylase activity
Tmath_1364	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Tmath_1365	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Tmath_1367	COG0194	GDP metabolic process
Tmath_1369	COG1561	YicC-like family, N-terminal region
Tmath_1370	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Tmath_1371	COG2814	Major facilitator Superfamily
Tmath_1375	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Tmath_1376	COG2011	ABC-type metal ion transport system permease component
Tmath_1377	COG1464	Belongs to the NlpA lipoprotein family
Tmath_1379	COG0037	tRNA processing
Tmath_1382	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Tmath_1384	COG0543	2 iron, 2 sulfur cluster binding
Tmath_1385	COG0284	orotidine-5'-phosphate decarboxylase activity
Tmath_1386	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Tmath_1387	COG0540	Belongs to the ATCase OTCase family
Tmath_1388	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Tmath_1390	COG0564	pseudouridine synthase activity
Tmath_1391	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Tmath_1400	COG0656	L-ascorbic acid biosynthetic process
Tmath_1402	COG1979	alcohol dehydrogenase
Tmath_1403	COG0667	Aldo Keto reductase
Tmath_1405	COG1970	mechanosensitive ion channel activity
Tmath_1407	COG1595	DNA-templated transcription, initiation
Tmath_1410	COG1983	PspC domain protein
Tmath_1414	COG0626	cystathionine gamma-synthase activity
Tmath_1416	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Tmath_1420	COG0134	indole-3-glycerol-phosphate synthase activity
Tmath_1421	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Tmath_1422	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Tmath_1422	COG0512	Glutamine amidotransferase of anthranilate synthase
Tmath_1426	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Tmath_1427	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Tmath_1428	COG0235	Class ii aldolase
Tmath_1431	COG0402	S-adenosylhomocysteine deaminase activity
Tmath_1432	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Tmath_1434	COG3599	regulation of cell shape
Tmath_1435	COG2302	S4 RNA-binding domain
Tmath_1437	COG1799	cell septum assembly
Tmath_1438	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Tmath_1441	COG1929	Belongs to the glycerate kinase type-1 family
Tmath_1446	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Tmath_1447	COG1160	GTP binding
Tmath_1455	COG0704	Plays a role in the regulation of phosphate uptake
Tmath_1456	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Tmath_1458	COG0573	inorganic phosphate transmembrane transporter activity
Tmath_1459	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Tmath_1460	COG5002	protein histidine kinase activity
Tmath_1461	COG0745	RESPONSE REGULATOR receiver
Tmath_1463	COG1873	PFAM PRC-barrel domain
Tmath_1464	COG1191	sigma factor activity
Tmath_1465	COG1191	sigma factor activity
Tmath_1467	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Tmath_1468	COG0849	cell division
Tmath_1469	COG3856	small basic protein
Tmath_1472	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Tmath_1473	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Tmath_1474	COG0772	Belongs to the SEDS family
Tmath_1476	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Tmath_1477	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Tmath_1478	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Tmath_1479	COG0768	penicillin binding
Tmath_1483	COG0612	Peptidase, M16
Tmath_1484	COG0612	Peptidase, M16
Tmath_1486	COG0012	GTP binding
Tmath_1493	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Tmath_1494	COG0321	lipoyl(octanoyl) transferase activity
Tmath_1495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Tmath_1511	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Tmath_1514	COG1362	aminopeptidase activity
Tmath_1515	COG2197	response regulator
Tmath_1518	COG1683	Conserved Protein
Tmath_1519	COG1193	negative regulation of DNA recombination
Tmath_1520	COG0826	peptidase U32
Tmath_1522	COG0072	phenylalanine-tRNA ligase activity
Tmath_1522	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tmath_1523	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Tmath_1524	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Tmath_1527	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Tmath_1530	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Tmath_1531	COG4399	Belongs to the UPF0754 family
Tmath_1534	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Tmath_1535	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Tmath_1536	COG1278	Cold shock
Tmath_1537	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Tmath_1540	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Tmath_1541	COG1956	GAF domain-containing protein
Tmath_1543	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Tmath_1549	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Tmath_1550	COG1482	cell wall glycoprotein biosynthetic process
Tmath_1551	COG0813	purine-nucleoside phosphorylase activity
Tmath_1552	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Tmath_1553	COG2384	SAM-dependent methyltransferase
Tmath_1554	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Tmath_1555	COG0358	DNA primase activity
Tmath_1556	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Tmath_1557	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Tmath_1558	COG0148	phosphopyruvate hydratase activity
Tmath_1560	COG0149	triose-phosphate isomerase activity
Tmath_1561	COG0126	phosphoglycerate kinase activity
Tmath_1563	COG2390	Transcriptional regulator
Tmath_1564	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Tmath_1565	COG1254	Belongs to the acylphosphatase family
Tmath_1566	COG0561	phosphatase activity
Tmath_1568	COG2720	vancomycin resistance protein
Tmath_1569	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Tmath_1570	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Tmath_1575	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Tmath_1577	COG0564	pseudouridine synthase activity
Tmath_1581	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Tmath_1582	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Tmath_1586	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Tmath_1589	COG3546	catalase activity
Tmath_1590	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Tmath_1591	COG0646	methionine synthase
Tmath_1591	COG1410	methionine synthase
Tmath_1592	COG0646	methionine synthase
Tmath_1592	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Tmath_1593	COG0058	SHG alpha-glucan phosphorylase activity
Tmath_1594	COG0166	Belongs to the GPI family
Tmath_1595	COG0778	Nitroreductase
Tmath_1598	COG0409	Hydrogenase expression formation protein
Tmath_1599	COG0298	carbon dioxide binding
Tmath_1600	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Tmath_1602	COG0375	protein maturation
Tmath_1606	COG3260	NADH ubiquinone oxidoreductase 20
Tmath_1607	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Tmath_1608	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Tmath_1608	COG2111	Na H antiporter
Tmath_1610	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Tmath_1612	COG1174	glycine betaine transport
Tmath_1613	COG1125	glycine betaine transport
Tmath_1613	COG0517	IMP dehydrogenase activity
Tmath_1614	COG3273	potassium ion transport
Tmath_1614	COG0471	metal ion transport
Tmath_1615	COG0534	Mate efflux family protein
Tmath_1617	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Tmath_1620	COG0205	6-phosphofructokinase activity
Tmath_1623	COG4109	DRTGG domain
Tmath_1624	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tmath_1625	COG1481	regulation of sporulation
Tmath_1627	COG0366	Alpha amylase catalytic
Tmath_1628	COG1426	Protein conserved in bacteria
Tmath_1631	COG3833	ABC-type maltose transport systems, permease component
Tmath_1632	COG1175	transmembrane transport
Tmath_1633	COG2182	Extracellular solute-binding protein
Tmath_1638	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Tmath_1643	COG2217	Heavy metal translocating P-type atpase
Tmath_1644	COG0482	sulfurtransferase activity
Tmath_1647	COG2608	mercury ion transmembrane transporter activity
Tmath_1648	COG0586	Pfam SNARE associated Golgi protein
Tmath_1649	COG1342	Belongs to the UPF0251 family
Tmath_1650	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Tmath_1652	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
Tmath_1656	COG1120	ATPase activity
Tmath_1657	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Tmath_1658	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
Tmath_1659	COG0446	pyridine nucleotide-disulphide oxidoreductase
Tmath_1660	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Tmath_1661	COG1234	tRNA 3'-trailer cleavage
Tmath_1663	COG0489	protein tyrosine kinase activity
Tmath_1664	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Tmath_1671	COG1609	Transcriptional regulator
Tmath_1672	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Tmath_1673	COG1621	beta-fructofuranosidase activity
Tmath_1676	COG2182	Extracellular solute-binding protein
Tmath_1680	COG0768	penicillin binding
Tmath_1683	COG0371	Dehydrogenase
Tmath_1684	COG1609	Transcriptional regulator
Tmath_1685	COG0235	Class ii aldolase
Tmath_1686	COG1069	ribulokinase activity
Tmath_1687	COG2160	L-arabinose isomerase activity
Tmath_1691	COG3534	alpha-L-arabinofuranosidase
Tmath_1692	COG0395	ABC-type sugar transport system, permease component
Tmath_1693	COG1175	transmembrane transport
Tmath_1694	COG1653	transport
Tmath_1695	COG3507	Belongs to the glycosyl hydrolase 43 family
Tmath_1699	COG0395	ABC-type sugar transport system, permease component
Tmath_1700	COG1175	transmembrane transport
Tmath_1701	COG1653	transport
Tmath_1702	COG0383	alpha-mannosidase activity
Tmath_1703	COG1917	Cupin 2, conserved barrel domain protein
Tmath_1703	COG4977	sequence-specific DNA binding
Tmath_1704	COG3250	beta-galactosidase activity
Tmath_1710	COG1940	carbohydrate kinase activity
Tmath_1711	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Tmath_1712	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Tmath_1713	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
Tmath_1717	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Tmath_1721	COG1904	glucuronate isomerase
Tmath_1722	COG0246	Mannitol dehydrogenase
Tmath_1723	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Tmath_1724	COG1070	Carbohydrate kinase
Tmath_1725	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Tmath_1727	COG1349	DNA-binding transcription factor activity
Tmath_1728	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Tmath_1731	COG0673	inositol 2-dehydrogenase activity
Tmath_1732	COG0673	inositol 2-dehydrogenase activity
Tmath_1739	COG3885	ferrous iron binding
Tmath_1739	COG2078	PFAM AMMECR1 domain protein
Tmath_1741	COG0318	PFAM AMP-dependent synthetase and ligase
Tmath_1742	COG1940	carbohydrate kinase activity
Tmath_1744	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Tmath_1748	COG0768	penicillin binding
Tmath_1752	COG0556	nucleotide-excision repair
Tmath_1753	COG2045	Belongs to the ComB family
Tmath_1755	COG3409	Peptidoglycan-binding domain 1 protein
Tmath_1755	COG0793	Belongs to the peptidase S41A family
Tmath_1756	COG0739	heme binding
Tmath_1757	COG2177	Part of the ABC transporter FtsEX involved in
Tmath_1758	COG2884	Cell division ATP-binding protein ftsE
Tmath_1759	COG3835	regulator
Tmath_1760	COG3842	ATPase activity
Tmath_1764	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Tmath_1765	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Tmath_1769	COG0849	cell division
Tmath_1774	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
Tmath_1774	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tmath_1774	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Tmath_1776	COG2376	Dihydroxyacetone kinase
Tmath_1777	COG3290	protein histidine kinase activity
Tmath_1777	COG3829	transcription factor binding
Tmath_1779	COG0446	pyridine nucleotide-disulphide oxidoreductase
Tmath_1782	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Tmath_1783	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
Tmath_1787	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Tmath_1791	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Tmath_1792	COG0140	phosphoribosyl-ATP diphosphatase activity
Tmath_1792	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Tmath_1795	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Tmath_1796	COG0131	Imidazoleglycerol-phosphate dehydratase
Tmath_1797	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Tmath_1798	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Tmath_1799	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Tmath_1800	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Tmath_1806	COG1131	(ABC) transporter
Tmath_1807	COG3459	Glycosyltransferase 36 associated
Tmath_1808	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Tmath_1808	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
Tmath_1809	COG0673	inositol 2-dehydrogenase activity
Tmath_1810	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Tmath_1812	COG0460	homoserine dehydrogenase
Tmath_1822	COG3958	Transketolase
Tmath_1823	COG3959	Transketolase, thiamine diphosphate binding domain
Tmath_1824	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Tmath_1829	COG2337	Toxic component of a toxin-antitoxin (TA) module
Tmath_1831	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Tmath_1833	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Tmath_1833	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Tmath_1834	COG0736	holo-[acyl-carrier-protein] synthase activity
Tmath_1842	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
Tmath_1843	COG1793	dna ligase
Tmath_1844	COG0432	Pfam Uncharacterised protein family UPF0047
Tmath_1861	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Tmath_1863	COG0732	type I restriction modification DNA specificity domain
Tmath_1864	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Tmath_1867	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Tmath_1871	COG0280	phosphate acetyltransferase
Tmath_1878	COG3426	butyrate kinase activity
Tmath_1879	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Tmath_1880	COG0280	phosphate acetyltransferase
Tmath_1881	COG3426	butyrate kinase activity
Tmath_1883	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
Tmath_1887	COG0546	phosphoglycolate phosphatase activity
Tmath_1889	COG1705	Flagellar rod assembly protein muramidase FlgJ
Tmath_1889	COG1388	LysM domain
Tmath_1894	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Tmath_1896	COG1966	Carbon starvation protein
Tmath_1898	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Tmath_1899	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Tmath_1900	COG0101	tRNA pseudouridine synthase activity
Tmath_1901	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Tmath_1902	COG1122	ATPase activity
Tmath_1903	COG1122	ATPase activity
Tmath_1904	COG0203	ribosomal protein L17
Tmath_1905	COG0202	RNA polymerase activity
Tmath_1906	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Tmath_1907	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Tmath_1908	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Tmath_1909	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Tmath_1910	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Tmath_1913	COG0563	adenylate kinase activity
Tmath_1914	COG0201	protein transport
Tmath_1915	COG0200	Binds to the 23S rRNA
Tmath_1916	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Tmath_1917	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Tmath_1919	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Tmath_1920	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Tmath_1921	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Tmath_1922	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Tmath_1923	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Tmath_1924	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Tmath_1925	COG0255	Belongs to the universal ribosomal protein uL29 family
Tmath_1926	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Tmath_1927	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Tmath_1928	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Tmath_1929	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Tmath_1930	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Tmath_1931	COG0089	rRNA binding
Tmath_1932	COG0088	Forms part of the polypeptide exit tunnel
Tmath_1933	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Tmath_1934	COG0051	transcription antitermination factor activity, RNA binding
Tmath_1935	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Tmath_1937	COG3688	RNA-binding protein containing a PIN domain
Tmath_1938	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Tmath_1940	COG0215	cysteine-tRNA ligase activity
Tmath_1941	COG1045	serine acetyltransferase
Tmath_1945	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Tmath_1947	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Tmath_1948	COG4956	integral membrane protein (PIN domain superfamily)
Tmath_1950	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Tmath_1951	COG1914	H( )-stimulated, divalent metal cation uptake system
Tmath_1953	COG3833	ABC-type maltose transport systems, permease component
Tmath_1954	COG1175	transmembrane transport
Tmath_1955	COG2182	Extracellular solute-binding protein
Tmath_1957	COG0542	response to heat
Tmath_1958	COG3869	Catalyzes the specific phosphorylation of arginine residues in
Tmath_1959	COG3880	PFAM UvrB UvrC protein
Tmath_1962	COG0281	malic enzyme
Tmath_1963	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Tmath_1964	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Tmath_1965	COG3706	GGDEF domain
Tmath_1965	COG0745	RESPONSE REGULATOR receiver
Tmath_1969	COG4224	UPF0291 protein
Tmath_1971	COG4946	Tricorn protease homolog
Tmath_1971	COG1506	peptidase
Tmath_1971	COG0823	Involved in the tonB-independent uptake of proteins
Tmath_1975	COG1131	(ABC) transporter
Tmath_1992	COG1489	DNA binding
Tmath_1993	COG0720	synthase
Tmath_1994	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Tmath_1995	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Tmath_1996	COG0302	gtp cyclohydrolase
Tmath_1997	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Tmath_1998	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Tmath_1999	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Tmath_1999	COG5322	oxidoreductase activity
Tmath_2004	COG0697	spore germination
Tmath_2005	COG0531	amino acid
Tmath_2006	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Tmath_2007	COG4684	Psort location CytoplasmicMembrane, score
Tmath_2008	COG4770	biotin carboxylase activity
Tmath_2010	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Tmath_2012	COG2759	Belongs to the formate--tetrahydrofolate ligase family
Tmath_2013	COG3852	Histidine kinase
Tmath_2016	COG0037	tRNA processing
Tmath_2017	COG2208	phosphoserine phosphatase activity
Tmath_2018	COG2226	methyltransferase
Tmath_2019	COG0697	spore germination
Tmath_2026	COG0860	N-Acetylmuramoyl-L-alanine amidase
Tmath_2031	COG2608	mercury ion transmembrane transporter activity
Tmath_2032	COG2217	Heavy metal translocating P-type atpase
Tmath_2041	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Tmath_2049	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Tmath_2049	COG0248	Ppx GppA phosphatase
Tmath_2050	COG1098	S1 RNA binding domain
Tmath_2057	COG2385	sporulation resulting in formation of a cellular spore
Tmath_2058	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Tmath_2059	COG0776	regulation of translation
Tmath_2060	COG3956	TIGRFAM MazG family protein
Tmath_2062	COG2814	Major facilitator Superfamily
Tmath_2063	COG1160	GTP binding
Tmath_2064	COG1027	Aspartate ammonia-lyase
Tmath_2065	COG2033	superoxide reductase activity
Tmath_2069	COG0142	geranyltranstransferase activity
Tmath_2072	COG1252	NADH dehydrogenase
Tmath_2079	COG1725	Transcriptional regulator
Tmath_2083	COG0165	Argininosuccinate lyase
Tmath_2084	COG0137	argininosuccinate synthase activity
Tmath_2086	COG0505	Belongs to the CarA family
Tmath_2087	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Tmath_2089	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Tmath_2096	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Tmath_2096	COG0493	'glutamate synthase
Tmath_2097	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Tmath_2097	COG1796	DNA polymerase
Tmath_2104	COG0671	phosphoesterase, PA-phosphatase related
Tmath_2105	COG3859	Proton-coupled thiamine transporter YuaJ
Tmath_2106	COG1132	(ABC) transporter
Tmath_2108	COG1846	Transcriptional regulator
Tmath_2109	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Tmath_2110	COG1454	alcohol dehydrogenase
Tmath_2110	COG1012	belongs to the aldehyde dehydrogenase family
Tmath_2112	COG0667	Aldo Keto reductase
Tmath_2113	COG0167	dihydroorotate dehydrogenase activity
Tmath_2114	COG0747	negative chemotaxis
Tmath_2115	COG0601	transmembrane transport
Tmath_2117	COG0444	Belongs to the ABC transporter superfamily
Tmath_2118	COG4608	Belongs to the ABC transporter superfamily
Tmath_2119	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Tmath_2120	COG0018	arginyl-trna synthetase
Tmath_2122	COG1181	Belongs to the D-alanine--D-alanine ligase family
Tmath_2124	COG2959	enzyme of heme biosynthesis
Tmath_2125	COG3773	Cell wall hydrolase
Tmath_2125	COG3409	Peptidoglycan-binding domain 1 protein
Tmath_2128	COG0531	amino acid
Tmath_2129	COG0697	spore germination
Tmath_2132	COG1802	Transcriptional regulator
Tmath_2134	COG1388	LysM domain
Tmath_2135	COG4466	Protein conserved in bacteria
Tmath_2137	COG2002	toxin-antitoxin pair type II binding
Tmath_2138	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Tmath_2139	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Tmath_2142	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tmath_2143	COG5002	protein histidine kinase activity
Tmath_2144	COG0745	RESPONSE REGULATOR receiver
Tmath_2145	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Tmath_2146	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Tmath_2148	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Tmath_2149	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Tmath_2155	COG0071	Belongs to the small heat shock protein (HSP20) family
Tmath_2159	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Tmath_2159	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Tmath_2159	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tmath_2161	COG1349	DNA-binding transcription factor activity
Tmath_2162	COG2373	Large extracellular alpha-helical protein
Tmath_2165	COG4991	sh3 domain protein
Tmath_2165	COG0515	serine threonine protein kinase
Tmath_2165	COG3064	Membrane
Tmath_2168	COG0504	CTP synthase activity
Tmath_2170	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Tmath_2173	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Tmath_2174	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Tmath_2176	COG3409	Peptidoglycan-binding domain 1 protein
Tmath_2176	COG0793	Belongs to the peptidase S41A family
Tmath_2177	COG0083	homoserine kinase activity
Tmath_2178	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Tmath_2179	COG0460	homoserine dehydrogenase
Tmath_2180	COG4492	Belongs to the UPF0735 family
Tmath_2181	COG0531	amino acid
Tmath_2182	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Tmath_2183	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Tmath_2184	COG1518	maintenance of DNA repeat elements
Tmath_2203	COG0822	iron-sulfur transferase activity
Tmath_2204	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Tmath_2206	COG0719	Fe-S assembly protein
Tmath_2207	COG0396	ATPase activity
Tmath_2208	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Tmath_2212	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Tmath_2214	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Tmath_2216	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tmath_2217	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Tmath_2221	COG5002	protein histidine kinase activity
Tmath_2224	COG0739	heme binding
Tmath_2226	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Tmath_2227	COG0308	aminopeptidase N
Tmath_2229	COG2333	competence protein COMEC
Tmath_2229	COG0658	competence protein
Tmath_2231	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Tmath_2232	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Tmath_2233	COG0840	transmembrane signaling receptor activity
Tmath_2235	COG1164	Oligoendopeptidase f
Tmath_2237	COG0733	neurotransmitter:sodium symporter activity
Tmath_2241	COG1394	ATPase activity, coupled to movement of substances
Tmath_2243	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
Tmath_2244	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
Tmath_2245	COG1527	subunit (C
Tmath_2246	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
Tmath_2247	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Tmath_2248	COG1269	ATP hydrolysis coupled proton transport
Tmath_2258	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Tmath_2259	COG0305	Participates in initiation and elongation during chromosome replication
Tmath_2260	COG0359	binds to the 23S rRNA
Tmath_2261	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
Tmath_2264	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Tmath_2265	COG0629	single-stranded DNA binding
Tmath_2266	COG0360	Binds together with S18 to 16S ribosomal RNA
Tmath_2267	COG4481	Protein conserved in bacteria
Tmath_2268	COG0668	transmembrane transport
Tmath_2274	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Tmath_2275	COG1475	DNA binding
Tmath_2276	COG1192	Involved in chromosome partitioning
Tmath_2281	COG0445	tRNA wobble uridine modification
Tmath_2282	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Tmath_2283	COG1847	R3H domain protein
Tmath_2284	COG0706	membrane insertase activity
Tmath_2285	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Tmath_2286	COG0594	ribonuclease P activity
Tmath_2287	COG0230	Belongs to the bacterial ribosomal protein bL34 family