locus-tag class description Thet_0001 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) Thet_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) Thet_0003 ENOG410848D S4 domain protein YaaA Thet_0007 ENOG4105F1K Glutamine amidotransferase Thet_0010 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Thet_0011 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Thet_0012 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Thet_0015 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) Thet_0017 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Thet_0018 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) Thet_0019 ENOG4105C01 Dihydroxy-acid dehydratase Thet_0020 ENOG4105C7K acetolactate synthase Thet_0021 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) Thet_0022 ENOG4108R6K riboflavin synthase, subunit alpha Thet_0025 ENOG4108REF Sporulation integral membrane protein ytvi Thet_0029 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) Thet_0032 ENOG4108Z6B deaminase Thet_0033 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Thet_0034 ENOG4105C6E dna polymerase iii Thet_0037 ENOG4105WMR Protein CrcB homolog Thet_0038 ENOG4105WMR Protein CrcB homolog Thet_0043 ENOG4105CHR reductase Thet_0045 ENOG4105WJF Thet_0046 ENOG4108WZW RNA polymerase sigma Thet_0055 ENOG4108J59 Extracellular solute-binding protein, family 5 Thet_0058 ENOG4105C3U ABC transporter Thet_0059 ENOG4108JQ7 (ABC) transporter Thet_0062 ENOG4105CKB glycosidase Thet_0063 ENOG4105CKB glycosidase Thet_0067 ENOG4105CPF Cell wall formation (By similarity) Thet_0068 ENOG4107EXU Short-chain dehydrogenase reductase Sdr Thet_0070 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) Thet_0071 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) Thet_0072 ENOG4106DSS Tartrate dehydratase subunit alpha Thet_0074 ENOG4108UN4 phage SPO1 DNA polymerase-related protein Thet_0079 ENOG4105CUC YeeE YedE family protein Thet_0081 ENOG41066VF YeeE YedE family protein Thet_0084 ENOG4105DKQ ROK family Thet_0085 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) Thet_0087 ENOG4105CXN decarboxylase Thet_0088 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) Thet_0089 ENOG4105X0R protein from nitrogen regulatory protein P-II Thet_0091 ENOG4107QRG dna polymerase iii Thet_0092 ENOG4105MA4 psp1 domain protein Thet_0093 ENOG4105CEU Arginine dihydrolase Thet_0094 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) Thet_0095 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) Thet_0097 ENOG4105KRN Transcriptional regulator, abrb family Thet_0098 ENOG4108JIC nucleoside recognition domain protein Thet_0100 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate Thet_0101 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) Thet_0102 ENOG4105F8V Hydrolase, tatD family Thet_0103 ENOG41069ER domain protein Thet_0104 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) Thet_0108 ENOG4105WJF Thet_0109 ENOG4108WZW RNA polymerase sigma Thet_0110 ENOG4105D1F ATP-binding protein Thet_0113 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Thet_0115 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) Thet_0116 ENOG4105D6A Electron transport complex Thet_0117 ENOG41080WF Electron transport complex, RnfABCDGE type, G subunit Thet_0118 ENOG4105DZB Electron transport complex Thet_0119 ENOG4105DGN Electron transport complex Thet_0120 ENOG4107SVV electron transport complex, RnfABCDGE type, B subunit Thet_0122 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Thet_0124 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) Thet_0125 ENOG41082DI 50s ribosomal protein l31 Thet_0126 ENOG4107104 thymidine kinase Thet_0127 ENOG4105CBJ Metal-dependent enzyme Thet_0130 ENOG41081FK Mediates zinc uptake. May also transport other divalent cations (By similarity) Thet_0131 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Thet_0132 ENOG4107WAU Protein tyrosine phosphatase Thet_0133 ENOG4108YZG isomerase Thet_0134 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) Thet_0138 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) Thet_0139 ENOG4105DCF alanine dehydrogenase Thet_0143 ENOG4105MT0 Sporulation transcriptional regulator spoiiid Thet_0145 ENOG4108JQA flagellar Thet_0146 ENOG4105CGA flagellar basal-body rod protein FlgG Thet_0153 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase Thet_0156 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Thet_0159 ENOG4105DT3 PTS system, galactitol-specific IIc component Thet_0163 ENOG4105CXK mandelate racemase muconate lactonizing Thet_0164 ENOG4105C5I Dehydrogenase Thet_0165 ENOG4108UHU Aldolase Thet_0166 ENOG4108SC4 )-transporter Thet_0167 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Thet_0168 ENOG4105YHU PTS system Thet_0170 ENOG4105F3R pts system mannose fructose sorbose family iid Thet_0171 ENOG4108IQ3 PTS system Thet_0173 ENOG4108UHU Aldolase Thet_0174 ENOG4105C5I Dehydrogenase Thet_0175 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) Thet_0176 ENOG4105CZN Potassium uptake protein Thet_0180 ENOG4108RCM Nitroreductase Thet_0183 ENOG4108KB2 LysR family Transcriptional regulator Thet_0190 ENOG4105CMG Carbohydrate kinase Thet_0191 ENOG4105DFW ABC transporter Thet_0192 ENOG4105EKQ RNA-directed DNA polymerase Thet_0194 ENOG4105C2J ABC transporter Thet_0195 ENOG4108HWW ABC transporter Thet_0198 ENOG4105ETE Transcriptional regulator (LacI family Thet_0199 ENOG4108RVA ribokinase Thet_0200 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) Thet_0201 ENOG4105C2J ABC transporter Thet_0202 ENOG4105CNN ABC, transporter Thet_0203 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator Thet_0204 ENOG4105EKQ RNA-directed DNA polymerase Thet_0206 ENOG4106KNT transcriptional regulator Thet_0207 ENOG4105C5Y PTS System Thet_0211 ENOG4108M21 Thet_0213 ENOG4105MUZ Protein of unknown function DUF2620 Thet_0214 ENOG4106M0N transport system permease protein Thet_0216 ENOG41080QX K07048 phosphotriesterase-related protein Thet_0217 ENOG4106PKC pyridoxal phosphate binding Thet_0218 ENOG4108626 Racemase Thet_0219 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) Thet_0220 ENOG4105D17 glycoside hydrolase, family 3 domain protein Thet_0221 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) Thet_0222 ENOG4105CE4 GlcNAc 6-P deacetylase Thet_0223 ENOG4105CHM Aminotransferase Thet_0224 ENOG4108ZB6 transcriptional regulator AsnC family Thet_0226 ENOG4105CE1 Ferrous iron transport protein b Thet_0227 ENOG4108JJB ABC transporter Thet_0228 ENOG4108YZP cobalt ABC transporter, inner membrane subunit CbiQ Thet_0229 ENOG4105G01 cobalamin (vitamin B12) biosynthesis CbiM protein Thet_0230 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) Thet_0231 ENOG4105MRR Transcriptional regulator (By similarity) Thet_0233 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) Thet_0236 ENOG4105UQX Mate efflux family protein Thet_0237 ENOG410624X efflux transporter, rnd family, mfp subunit Thet_0238 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Thet_0239 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Thet_0240 ENOG4105ERH Fumarylacetoacetate hydrolase Thet_0242 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination Thet_0245 ENOG4105EYH Exonuclease Thet_0247 ENOG4105D3R alkyl hydroperoxide reductase Thet_0251 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) Thet_0252 ENOG4107QPH glycogen) synthase Thet_0256 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) Thet_0262 ENOG4107NFR Fructose-1,6-bisphosphatase Thet_0262 ENOG4107NFR Fructose-1,6-bisphosphatase Thet_0264 ENOG4105C2F Histidine kinase Thet_0265 ENOG4108VB1 regulatoR Thet_0266 ENOG4105DFW ABC transporter Thet_0267 ENOG4105DFW ABC transporter Thet_0268 ENOG4105C2J ABC transporter Thet_0269 ENOG4108HWW ABC transporter Thet_0270 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor Thet_0271 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor Thet_0274 ENOG4105DF9 Lipoate-protein, ligase Thet_0275 ENOG4107QN2 dihydrolipoyl dehydrogenase Thet_0277 ENOG4105CHM Aminotransferase Thet_0278 ENOG4106ETB IIa component Thet_0279 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC Thet_0283 ENOG4107QW4 alcohol dehydrogenase Thet_0290 ENOG4105MKU Transcriptional regulator Thet_0293 ENOG4105CIZ coA-substrate-specific enzyme activase Thet_0295 ENOG4108T5I Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) Thet_0296 ENOG4105C4B ABC transporter, permease Thet_0297 ENOG4105C8T Leucyl-tRNA synthetase Thet_0298 ENOG4108UMN azlc family Thet_0300 ENOG4105DD7 kinase (PfkB family Thet_0301 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) Thet_0302 ENOG41089WN small, acid-soluble spore protein tlp Thet_0303 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Thet_0307 ENOG4105VCP PTS System Thet_0308 ENOG4105F8D glycoside hydrolase family 4 Thet_0309 ENOG4105CS2 ec 3.2.1.21 Thet_0310 ENOG4105CTS PTS system mannitol-specific Thet_0311 ENOG4105EMD TRANSCRIPTIONal Thet_0314 ENOG4105CGH 5'-nucleotidase Thet_0315 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) Thet_0316 ENOG4105EJ9 Membrane Thet_0319 ENOG4105FDK ABC transporter Thet_0320 ENOG4105DSE periplasmic solute binding protein Thet_0321 ENOG4105N80 Ferric uptake regulator, Fur family Thet_0322 ENOG4105C7R Atpase associated with various cellular activities aaa_3 Thet_0325 ENOG4108V0P LemA family Thet_0326 ENOG4105DUM transcriptional regulator, lysR family Thet_0327 ENOG4105D5B Sulfite reductase, subunit A Thet_0328 ENOG4107SHJ sulfite reductase subunit b Thet_0329 ENOG410810Y Sulfite reductase Thet_0333 ENOG4107YH3 SUF system FeS assembly protein, NifU family Thet_0336 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) Thet_0339 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) Thet_0340 ENOG4105EHG Permease protein Thet_0341 ENOG4105E0A ABC, transporter Thet_0342 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) Thet_0347 ENOG4105CIH Imidazole acetol-phosphate transaminase Thet_0348 ENOG4108YZT Adenosylcobinamide kinase Thet_0351 ENOG41081F0 Precorrin-8x methylmutase Thet_0354 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase Thet_0355 ENOG4105DVK Precorrin-2 c20-methyltransferase Thet_0356 ENOG4105CIA precorrin-4 C(11)-methyltransferase Thet_0357 ENOG4108P62 biosynthesis protein (CbiG) Thet_0358 ENOG4105E4R Precorrin-3B C17-methyltransferase Thet_0359 ENOG4108JTQ reductase Thet_0360 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) Thet_0363 ENOG4105D52 delta-aminolevulinic acid dehydratase Thet_0364 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase Thet_0365 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) Thet_0368 ENOG4108JJB ABC transporter Thet_0373 ENOG4108IUW ABC transporter Thet_0383 ENOG4105FDK ABC transporter Thet_0385 ENOG4108IUW ABC transporter Thet_0386 ENOG4108SDH ABC, transporter Thet_0393 ENOG4108ZXC Two component transcriptional regulator, luxr family Thet_0396 ENOG4105CJ1 ABC, transporter Thet_0407 ENOG4105FDK ABC transporter Thet_0409 ENOG4108IUW ABC transporter Thet_0410 ENOG4108SDH ABC, transporter Thet_0419 ENOG4105DA5 (ABC) transporter Thet_0423 ENOG4105CN9 Peptidase m42 family protein Thet_0424 ENOG4105CN9 Peptidase m42 family protein Thet_0425 ENOG4105CN9 Peptidase m42 family protein Thet_0430 ENOG4105EKQ RNA-directed DNA polymerase Thet_0432 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Thet_0436 ENOG41080BE Methyl-accepting chemotaxis sensory transducer Thet_0437 ENOG4105CCS Glutamate formiminotransferase Thet_0438 ENOG4105CI2 imidazolone-5-propionate hydrolase Thet_0441 ENOG4107V4V glycoside hydrolase family 4 Thet_0444 ENOG4107T3P ABC, transporter Thet_0445 ENOG4105C2F Histidine kinase Thet_0446 ENOG4105EQD regulatoR Thet_0447 ENOG410908R Methenyltetrahydrofolate cyclohydrolase Thet_0448 ENOG4107TFB basic membrane Thet_0449 ENOG4108JQ9 ABC transporter Thet_0450 ENOG4105UIB (ABC) transporter Thet_0454 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) Thet_0456 ENOG4105C8Q Methyl-accepting chemotaxis Thet_0458 ENOG4105CI1 PTS System Thet_0459 ENOG4105C5Y PTS System Thet_0461 ENOG4107SDT Homocitrate synthase Thet_0470 ENOG4105CBX hi0933 family Thet_0471 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) Thet_0473 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) Thet_0475 ENOG41066UU tRNA (Adenine-N1-)-methyltransferase Thet_0479 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit Thet_0480 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) Thet_0483 ENOG4105H67 Protein of unknown function (DUF421) Thet_0484 ENOG410667J hydrolase Thet_0486 ENOG4105ETE Transcriptional regulator (LacI family Thet_0487 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Thet_0488 ENOG4105BZU Histidine kinase Thet_0492 ENOG4108RAC Rubrerythrin Thet_0493 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP Thet_0494 ENOG4105C7H Helicase, RecD TraA family Thet_0495 ENOG4105MJ2 Competence protein Thet_0499 ENOG4105E1Q flagellar hook-associated protein Thet_0500 ENOG4105DTJ flagellar hook-associated protein Thet_0502 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) Thet_0503 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) Thet_0509 ENOG4105CAQ asparagine synthetase Thet_0512 ENOG4107RT6 flagellar hook-associated Thet_0513 ENOG4105MQ3 flagellar protein FliS Thet_0518 ENOG4108HW3 (ABC) transporter Thet_0519 ENOG4105E5Q amino acid AbC transporter Thet_0523 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Thet_0525 ENOG4108Z3G 3H domain protein Thet_0527 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving Thet_0532 ENOG4105CD3 dihydroorotase Thet_0533 ENOG4105CEU Arginine dihydrolase Thet_0534 ENOG4105DBV ornithine carbamoyltransferase Thet_0535 ENOG4105C5B carbamate kinase Thet_0537 ENOG4105EKQ RNA-directed DNA polymerase Thet_0538 ENOG4105K8N protein family UPF0079, ATPase Thet_0539 ENOG41072GX Peptidase M22 Glycoprotease Thet_0541 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Thet_0543 ENOG4105C5H ABC transporter Thet_0544 ENOG4105E14 MotA TolQ exbB proton channel Thet_0545 ENOG4106VK6 Flagellar motor protein Thet_0548 ENOG4105DY9 regulatoR Thet_0549 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism Thet_0553 ENOG4105CDJ oxidoreductase FAD NAD(P)-binding domain protein Thet_0554 ENOG4105BZ8 glutamate synthase Thet_0557 ENOG4108UQV Membrane Thet_0559 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin Thet_0565 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) Thet_0566 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) Thet_0567 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) Thet_0568 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) Thet_0569 ENOG4105C7N Xanthine uracil vitamin C permease Thet_0570 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) Thet_0571 ENOG4105C8V SAICAR synthetase Thet_0572 ENOG4105VR9 phosphoribosylformylglycinamidine synthase Thet_0573 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I Thet_0577 ENOG4108V3E phosphoribosylglycinamide formyltransferase Thet_0579 ENOG4107QNG Phosphoribosylglycinamide synthetase Thet_0581 ENOG4105CH2 amidohydrolase Thet_0582 ENOG4105CKP Polysaccharide Biosynthesis Protein Thet_0584 ENOG4105ETD TRANSCRIPTIONal Thet_0586 ENOG4105VZJ PTS System Thet_0587 ENOG4105CK1 PTS System Thet_0588 ENOG4105VCP PTS System Thet_0589 ENOG4105KGF protein, YerC YecD Thet_0590 ENOG4105C4R Atp-dependent dna helicase Thet_0592 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) Thet_0600 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Thet_0601 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Thet_0603 ENOG4108JQ7 (ABC) transporter Thet_0605 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) Thet_0610 ENOG4108YZA Nitrogen regulatory protein pii Thet_0613 ENOG4105EYU Glutamine amido-transferase Thet_0614 ENOG4105CBC glutamate synthase Thet_0615 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein Thet_0618 ENOG4107QW8 radical SAM domain protein Thet_0623 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) Thet_0628 ENOG4108UTW Plays a role in the regulation of phosphate uptake Thet_0629 ENOG4108IV0 ABC, transporter Thet_0632 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation Thet_0633 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Thet_0635 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) Thet_0636 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) Thet_0639 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component Thet_0641 ENOG4105D2X ABC transporter substrate-binding protein Thet_0643 ENOG4105CJW magnesium transporter Thet_0650 ENOG4105CPK Glycosyl transferase (Group 1 Thet_0651 ENOG4107T8Q Glycosyl transferase (Group 1 Thet_0652 ENOG4107EF8 Glycosyl transferase (Group 1 Thet_0654 ENOG4107STW synthase Thet_0655 ENOG4105C6Y Udp-glucose 6-dehydrogenase Thet_0656 ENOG4105D3Q Sugar transferase Thet_0667 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 Thet_0670 ENOG41084HI prevent-host-death family Thet_0675 ENOG4108V0P LemA family Thet_0676 ENOG4108RE9 Phosphodiesterase Thet_0677 ENOG4107QM2 Aldo Keto reductase Thet_0681 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Thet_0683 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) Thet_0694 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) Thet_0697 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase Thet_0698 ENOG4105HTX biosynthesis protein Thet_0699 ENOG4107YJ4 chain length determinant protein Thet_0701 ENOG4108KGH TRANSCRIPTIONal Thet_0702 ENOG4108K88 Membrane Thet_0706 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) Thet_0707 ENOG4105C0R drug resistance transporter emrb qaca subfamily Thet_0710 ENOG4105EKQ RNA-directed DNA polymerase Thet_0713 ENOG4108UKJ Cdp-alcohol phosphatidyltransferase Thet_0715 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase Thet_0716 ENOG4105C8M UPF0272 protein Thet_0717 ENOG4105C8M UPF0272 protein Thet_0718 ENOG4105BZU Histidine kinase Thet_0719 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Thet_0724 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) Thet_0726 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase Thet_0731 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) Thet_0732 ENOG4107KJX Transcriptional regulator Thet_0735 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component Thet_0736 ENOG4105DRS transport system, permease Thet_0737 ENOG4107URF beta-phospho-glucomutase Thet_0738 ENOG4105ETE Transcriptional regulator (LacI family Thet_0740 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component Thet_0743 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin Thet_0744 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Thet_0745 ENOG4105F0V Cell wall hydrolase Thet_0748 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase Thet_0750 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) Thet_0751 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Thet_0752 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) Thet_0754 ENOG4105BZ1 (ABC) transporter Thet_0755 ENOG4105BZ1 (ABC) transporter Thet_0758 ENOG4105M3Z response regulator Thet_0759 ENOG4105DYB Isoaspartyl dipeptidase Thet_0760 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Thet_0762 ENOG4105DR5 peptidase Thet_0765 ENOG4105C84 Histidine ammonia-lyase Thet_0774 ENOG4108UIC UPF0340 protein Thet_0779 ENOG4105C2M dna polymerase I Thet_0780 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) Thet_0781 ENOG4105E4C Lytic transglycosylase catalytic Thet_0784 ENOG4107TT5 NLP P60 protein Thet_0786 ENOG4105E4C Lytic transglycosylase catalytic Thet_0790 ENOG4108R3D Electron transport complex Thet_0793 ENOG410902H NADH dehydrogenase (Ubiquinone), 24 kDa subunit Thet_0794 ENOG4105BZU Histidine kinase Thet_0796 ENOG4107QIZ NADH dehydrogenase Thet_0797 ENOG4107QHI -hydrogenase Thet_0799 ENOG4108Z03 MAF-like protein Thet_0800 ENOG4105W5Q DNA repair protein (RadC Thet_0801 ENOG4105DFF Rod shape-determining protein mreb Thet_0804 ENOG4105CJN penicillin-binding protein Thet_0805 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) Thet_0806 ENOG4107QMS site-determining protein Thet_0807 ENOG41083CN Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) Thet_0808 ENOG4105CNI cell division protein FtsW Thet_0809 ENOG4108Z5K methylglyoxal synthase Thet_0810 ENOG4105DR5 peptidase Thet_0814 ENOG4105C03 ribonuclease Thet_0815 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) Thet_0816 ENOG410807C QueT transporter Thet_0818 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) Thet_0820 ENOG4105K46 50S ribosomal protein l27 Thet_0822 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control Thet_0823 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) Thet_0824 ENOG4108WF2 Metal Dependent Phosphohydrolase Thet_0825 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) Thet_0829 ENOG4105CAQ asparagine synthetase Thet_0830 ENOG4105DZ1 carboxypeptidase Thet_0831 ENOG4105KQC Competence protein Thet_0832 ENOG4108W5N phosphatidylglycerophosphatase a Thet_0835 ENOG41084EF Ferredoxin Thet_0836 ENOG4105CM2 brancheD-chain amino acid aminotransferase Thet_0840 ENOG4105PUK Membrane Thet_0842 ENOG4107R1N Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) Thet_0845 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) Thet_0847 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) Thet_0853 ENOG4105CSA Coproporphyrinogen iii oxidase Thet_0855 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ Thet_0857 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) Thet_0859 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) Thet_0860 ENOG4105VUC UPF0237 protein Thet_0863 ENOG4107S21 permease Thet_0865 ENOG4107QSE Dipeptidase Thet_0866 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) Thet_0868 ENOG4108ZGC gaf domain protein Thet_0869 ENOG41083MR nifu domain-containing protein Thet_0871 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) Thet_0872 ENOG4105VEQ Cold shock protein Thet_0873 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) Thet_0874 ENOG4105XXY Thioredoxin Thet_0875 ENOG41065U4 response regulator Thet_0878 ENOG4108UH6 UPF0754 membrane protein Thet_0879 ENOG4105C22 threonyL-tRNA synthetase Thet_0882 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) Thet_0885 ENOG4108RWN rrna methyltransferase Thet_0886 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) Thet_0887 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) Thet_0889 ENOG4105CFP Peptidase U32 Thet_0890 ENOG4105C98 muts2 protein Thet_0891 ENOG4105EWC Purine nucleoside phosphorylase Thet_0894 ENOG4105WH1 Two component transcriptional regulator luxr family Thet_0895 ENOG4105DFM M18 family aminopeptidase Thet_0901 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) Thet_0903 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) Thet_0904 ENOG4107RUY (E1 component), alpha subunit Thet_0906 ENOG4106Z86 ATP-nad acox kinase Thet_0907 ENOG4107QKR Dehydrogenase Thet_0910 ENOG4105EKQ RNA-directed DNA polymerase Thet_0915 ENOG4105C3G gtp-binding protein Thet_0921 ENOG41068JM cell division protein, FtsL Thet_0922 ENOG4105CJN penicillin-binding protein Thet_0923 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) Thet_0924 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) Thet_0925 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) Thet_0927 ENOG4105CNI cell division protein FtsW Thet_0928 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) Thet_0929 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) Thet_0932 ENOG4105K67 small basic protein Thet_0933 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) Thet_0934 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) Thet_0935 ENOG4108AWX Sporulation factor SpoIIGA Thet_0936 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Thet_0937 ENOG4105E65 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Thet_0938 ENOG4108BIK prc-barrel domain-containing protein Thet_0940 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Thet_0941 ENOG4105BZU Histidine kinase Thet_0942 ENOG4105CVA phosphate Thet_0943 ENOG4105C8U phosphate abc transporter Thet_0944 ENOG4105E2Z phosphate ABC transporter (Permease Thet_0945 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) Thet_0946 ENOG4108UTW Plays a role in the regulation of phosphate uptake Thet_0949 ENOG4105S2F Thet_0957 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) Thet_0959 ENOG4108VYJ response regulator receiver protein Thet_0960 ENOG4105E9Q Acyl-transferase Thet_0962 ENOG4105C0X amino acid Thet_0963 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving Thet_0965 ENOG4105CJ1 ABC, transporter Thet_0966 ENOG4105C0R drug resistance transporter emrb qaca subfamily Thet_0970 ENOG4108JUB Transcriptional regulator Thet_0971 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin Thet_0977 ENOG4105C2F Histidine kinase Thet_0978 ENOG4105WH1 Two component transcriptional regulator luxr family Thet_0981 ENOG4105KNY Microcompartments protein Thet_0982 ENOG4105EHR propanediol utilization protein pduB Thet_0984 ENOG4105YCI dehydratase medium subunit Thet_0985 ENOG4108ZFT Dehydratase small subunit Thet_0986 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit Thet_0988 ENOG4105KNY Microcompartments protein Thet_0989 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) Thet_0990 ENOG4107RWI ethanolamine utilization protein eutJ Thet_0992 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml Thet_0994 ENOG4108EKI Dehydrogenase Thet_0996 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) Thet_0997 ENOG4108X49 Ethanolamine utilization protein EutK Thet_0998 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place Thet_0999 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) Thet_1000 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) Thet_1001 ENOG4105C0A alcohol dehydrogenase Thet_1002 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) Thet_1003 ENOG4105EHG Permease protein Thet_1004 ENOG4105E0A ABC, transporter Thet_1010 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) Thet_1011 ENOG4108HHA Transketolase Thet_1012 ENOG4108IUS Transketolase Thet_1013 ENOG4108YZG isomerase Thet_1015 ENOG4105DB7 PHP domain protein Thet_1016 ENOG4105D2N Aldolase Thet_1017 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Thet_1020 ENOG4105C26 Dehydrogenase Thet_1025 ENOG4105CMT Dihydroxyacetone kinase Thet_1027 ENOG4108UTZ Dihydroxyacetone kinase Thet_1034 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) Thet_1039 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR Thet_1040 ENOG4105BZW Glycerate kinase Thet_1041 ENOG4105C6Z Gluconate Thet_1042 ENOG4105KME endoribonuclease L-psp Thet_1045 ENOG4105DFA alanine racemase domain protein Thet_1046 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) Thet_1048 ENOG4105DBK s4 domain protein Thet_1051 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) Thet_1052 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) Thet_1053 ENOG4105CR5 Class II aldolase adducin family protein Thet_1054 ENOG4105FDP GntR family transcriptional regulator Thet_1056 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) Thet_1057 ENOG4108JJB ABC transporter Thet_1058 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) Thet_1059 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) Thet_1067 ENOG4105CRQ synthase (Component I) Thet_1068 ENOG4105DDQ anthranilate synthase Thet_1069 ENOG4108I0Q anthranilate phosphoribosyltransferase Thet_1074 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase Thet_1075 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Thet_1076 ENOG4105C28 cystathionine Thet_1083 ENOG4105DJT lAO AO transport system ATPase Thet_1084 ENOG4108ZVT methylmalonyl-coA epimerase Thet_1086 ENOG4105D9Q decarboxylase (Beta subunit) Thet_1089 ENOG4108AEY RNA polymerase sigma factor Thet_1090 ENOG4108TVJ Nitroreductase Thet_1093 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) Thet_1107 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) Thet_1109 ENOG4107QMH DNA methylase Thet_1114 ENOG4105KNA -acetyltransferase Thet_1115 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) Thet_1116 ENOG4105C34 Pseudouridine synthase Thet_1117 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii Thet_1118 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) Thet_1119 ENOG4105CXT aspartate transcarbamylase Thet_1120 ENOG4105CD3 dihydroorotase Thet_1122 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) Thet_1124 ENOG4107XPQ Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) Thet_1126 ENOG4105DR4 Methyltransferase Thet_1127 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) Thet_1129 ENOG4105D01 (LipO)protein Thet_1130 ENOG4108UMI ABC transporter, permease Thet_1131 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) Thet_1133 ENOG4105F23 Fibronectin-binding protein Thet_1135 ENOG4105C6X Major Facilitator Thet_1136 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) Thet_1137 ENOG4105DSJ YicC domain protein Thet_1139 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) Thet_1141 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase Thet_1142 ENOG4105C25 Primosomal protein n' Thet_1145 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) Thet_1148 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B Thet_1149 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs Thet_1150 ENOG4108ZF3 Phosphatase Thet_1151 ENOG4105D9P serine threonine protein kinase Thet_1152 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) Thet_1153 ENOG4105DJV ribulose-phosphate 3-epimerase Thet_1157 ENOG4108ZAA Alkaline-shock protein Thet_1158 ENOG4105DP4 dak2 domain fusion protein ylov Thet_1159 ENOG4105CB5 ATP-dependent DNA helicase recG Thet_1160 ENOG4105EPR degv family Thet_1163 ENOG4106H78 methyltransferase Thet_1164 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) Thet_1166 ENOG4105H20 Sporulation integral membrane protein YlbJ Thet_1168 ENOG4108IJ2 phosphate acetyltransferase Thet_1169 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) Thet_1170 ENOG4105KNH Nucleic acid-binding protein Thet_1171 ENOG41067VY 50S ribosomal protein L32 Thet_1172 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) Thet_1174 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) Thet_1175 ENOG4105EA8 2-Nitropropane dioxygenase Thet_1176 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase Thet_1177 ENOG4105CHR reductase Thet_1178 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) Thet_1179 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) Thet_1180 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) Thet_1182 ENOG4105MCT stage V sporulation protein S Thet_1185 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) Thet_1186 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) Thet_1189 ENOG4105VB6 UPF0109 protein Thet_1190 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) Thet_1191 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) Thet_1192 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) Thet_1194 ENOG4105C0P Mg chelatase subunit ChlI Thet_1195 ENOG4108JYZ YitT family Thet_1196 ENOG4105C31 Tryptophanyl-tRNA synthetase Thet_1197 ENOG4105VFF UPF0102 protein Thet_1198 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Thet_1200 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) Thet_1204 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) Thet_1205 ENOG4108ZC9 flagellar basal-body rod protein flgc Thet_1206 ENOG4105VQ0 flagellar hook-basal body complex protein fliE Thet_1207 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) Thet_1208 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) Thet_1214 ENOG410822I Flagellar hook capping protein Thet_1216 ENOG4105BZE flagellar hook protein, FlgE Thet_1217 ENOG41068WV flagellar FlbD family protein Thet_1219 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) Thet_1220 ENOG4105DD5 Flagellar motor switch protein Thet_1221 ENOG4107YTP response regulator receiver protein Thet_1223 ENOG4105CN7 Flagellar biosynthetic protein FliP Thet_1224 ENOG4105VS8 Flagellar biosynthetic protein fliq Thet_1225 ENOG4105D19 Role in flagellar biosynthesis (By similarity) Thet_1226 ENOG4105D00 flagellar biosynthetic protein flhB Thet_1227 ENOG4105D7B Flagellar biosynthesis protein flha Thet_1228 ENOG4105FZW flagellar biosynthesis regulator FlhF Thet_1231 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) Thet_1232 ENOG4105CBS Chea signal transduction histidine kinase Thet_1233 ENOG4108V3W Chemotaxis protein, CheW Thet_1235 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) Thet_1236 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Thet_1240 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) Thet_1241 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) Thet_1242 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) Thet_1244 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) Thet_1245 ENOG4105KNE Phosphatidate cytidylyltransferase Thet_1247 ENOG4105DZP Membrane-associated zinc metalloprotease Thet_1248 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) Thet_1250 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) Thet_1252 ENOG4105CHV Transcription elongation factor NusA Thet_1253 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination Thet_1256 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) Thet_1258 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) Thet_1259 ENOG4105DTN riboflavin biosynthesis protein ribF Thet_1260 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) Thet_1263 ENOG4105C1V Peptidase, M16 Thet_1264 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) Thet_1267 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit Thet_1269 ENOG4105CNU cell division protein FtsK Thet_1271 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase Thet_1273 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) Thet_1274 ENOG410902V Modulates RecA activity (By similarity) Thet_1276 ENOG4105D48 metallophosphoesterase Thet_1277 ENOG4105MCT stage V sporulation protein S Thet_1278 ENOG4105DB7 PHP domain protein Thet_1280 ENOG4105C83 adenylosuccinate lyase Thet_1281 ENOG4106F1P AAA ATPase, central domain protein Thet_1282 ENOG4105CXI aluminum resistance protein Thet_1283 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Thet_1284 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Thet_1285 ENOG4105II7 pyrroline-5-carboxylate reductase Thet_1286 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) Thet_1287 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) Thet_1289 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) Thet_1291 ENOG4105BZU Histidine kinase Thet_1292 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) Thet_1294 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) Thet_1296 ENOG4105CAT Cytidine monophosphate kinase Thet_1297 ENOG4105KHN chorismate mutase Thet_1299 ENOG4105CBX hi0933 family Thet_1300 ENOG4105CVJ phosphoglycerate mutase Thet_1303 ENOG4105CFM UPF0317 protein Thet_1305 ENOG4105P4J Allophanate hydrolase, subunit 1 Thet_1306 ENOG4105E7W lamb ycsf family protein Thet_1307 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) Thet_1309 ENOG4108J9M Transporter Thet_1311 ENOG4105D82 Glutamate dehydrogenase Thet_1312 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) Thet_1314 ENOG4105DQU oxidoreductase, subunit beta Thet_1315 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein Thet_1317 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) Thet_1320 ENOG4107QSA Oxaloacetate decarboxylase Thet_1321 ENOG4105CYW agmatinase Thet_1322 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) Thet_1324 ENOG4105FE9 pseudouridine synthase Thet_1325 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) Thet_1327 ENOG4105DZ1 carboxypeptidase Thet_1329 ENOG4105DI5 UPF0365 protein Thet_1330 ENOG4105F7J membrane-bound serine protease Thet_1332 ENOG4105KBJ sporulation protein ytfj Thet_1334 ENOG4105PTM secreted protein Thet_1335 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) Thet_1336 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) Thet_1337 ENOG4108Z4T Peptidase M50 Thet_1341 ENOG41090VF Stage v sporulation protein ac Thet_1342 ENOG41084UG Pfam:DUF1458 Thet_1343 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Thet_1344 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) Thet_1346 ENOG4105DZ1 carboxypeptidase Thet_1347 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Thet_1348 ENOG4105MZ9 stage II sporulation protein m Thet_1357 ENOG4107QQR Sporulation Thet_1358 ENOG4105S1Z Stage IV sporulation protein B Thet_1359 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) Thet_1361 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) Thet_1362 ENOG4105DX0 Hemolysin A Thet_1363 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) Thet_1365 ENOG4105CTB Polyprenyl synthetase Thet_1368 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) Thet_1369 ENOG4105M7K Involved in the transcription termination process (By similarity) Thet_1370 ENOG4108ZSR alkaline shock protein Thet_1373 ENOG410644B Stage III sporulation protein af Thet_1375 ENOG4105KQ4 Stage iii sporulation protein ad Thet_1376 ENOG4108CQH stage III sporulation protein AC Thet_1378 ENOG4105CD2 stage iii sporulation protein aa Thet_1380 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) Thet_1381 ENOG4105DC7 peptidase M24 Thet_1382 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) Thet_1384 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) Thet_1398 ENOG4105CZX twitching motility protein Thet_1399 ENOG4107QHF type ii secretion system protein e Thet_1400 ENOG4105E2X shikimate dehydrogenase Thet_1401 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) Thet_1402 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Thet_1403 ENOG4105CJN penicillin-binding protein Thet_1404 ENOG4105CFP Peptidase U32 Thet_1405 ENOG4108VQJ O-methyltransferase Thet_1406 ENOG4105HHA aminodeoxychorismate lyase Thet_1407 ENOG410807C QueT transporter Thet_1408 ENOG41084CE UPF0342 protein Thet_1409 ENOG4105CN5 Metallo-Beta-Lactamase Thet_1410 ENOG4105I3K Ferric uptake regulator, Fur family Thet_1411 ENOG41085AS UPF0473 protein Thet_1413 ENOG4105VBH UPF0297 protein Thet_1414 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) Thet_1415 ENOG4105C02 permease Thet_1417 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) Thet_1420 ENOG4106M28 alanine racemase domain protein Thet_1422 ENOG4105EQ5 D-Lysine 5,6-aminomutase alpha subunit Thet_1423 ENOG4105KIJ D-ornithine aminomutase S component Thet_1424 ENOG4107RH1 pyridoxal-5'-phosphate-dependent protein beta subunit Thet_1426 ENOG4108KR4 dihydrodipicolinate reductase Thet_1427 ENOG4105K63 Thioredoxin Thet_1428 ENOG4105VPX protein, conserved in bacteria Thet_1429 ENOG4105CUZ uba thif-type nad fad binding protein Thet_1433 ENOG4107VMB Beta-lactamase domain protein Thet_1435 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) Thet_1437 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) Thet_1439 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Thet_1440 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Thet_1447 ENOG41061AI Protein of unknown function (DUF2905) Thet_1448 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) Thet_1449 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) Thet_1450 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) Thet_1452 ENOG4108V3W Chemotaxis protein, CheW Thet_1453 ENOG4105CDY transcriptional regulatory protein Thet_1454 ENOG4105C6T cysteine synthase Thet_1458 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein Thet_1461 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) Thet_1462 ENOG4105JFG SpoIID LytB domain protein Thet_1465 ENOG4105CXN decarboxylase Thet_1466 ENOG4105K63 Thioredoxin Thet_1467 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Thet_1468 ENOG4107QIV Cytochrome c biogenesis protein Thet_1475 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase Thet_1476 ENOG4105EVN Prephenate dehydrogenase Thet_1477 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase Thet_1478 ENOG4105CQC Prephenate dehydratase Thet_1480 ENOG4105DPN Oligoendopeptidase f Thet_1481 ENOG4105EJQ L-serine dehydratase Thet_1484 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) Thet_1485 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase Thet_1488 ENOG4108UXE Protein tyrosine phosphatase Thet_1489 ENOG4105CNW domain protein Thet_1492 ENOG41066FP Small acid-soluble spore protein I Thet_1495 ENOG4108UVJ appr-1-p processing domain protein Thet_1497 ENOG4108QXE glycerophosphoryl diester phosphodiesterase Thet_1501 ENOG4107S9D Alpha beta hydrolase Thet_1510 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family Thet_1511 ENOG4105CVM Molybdenum cofactor synthesis domain protein Thet_1512 ENOG4108RIR Molybdenum cofactor biosynthesis protein Thet_1518 ENOG4105D06 uba thif-type nad fad binding protein Thet_1521 ENOG4105WE2 aldehyde ferredoxin oxidoreductase Thet_1526 ENOG4108Z0Z intracellular protease Pfpi family Thet_1529 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) Thet_1533 ENOG4105BZ1 (ABC) transporter Thet_1539 ENOG4105BZ1 (ABC) transporter Thet_1550 ENOG4105BZ1 (ABC) transporter Thet_1553 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) Thet_1555 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) Thet_1556 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) Thet_1558 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) Thet_1562 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) Thet_1564 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) Thet_1565 ENOG4105CTJ Metal Dependent Phosphohydrolase Thet_1566 ENOG4105C9A Phoh family Thet_1568 ENOG41068P3 sporulation protein YqfC Thet_1569 ENOG4105HDK L-asparaginase Thet_1571 ENOG4105VCC 30S ribosomal protein S21 Thet_1572 ENOG4107YU2 histidine triad (hIT) protein Thet_1573 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) Thet_1574 ENOG4105EDW glycosyl transferase, family 39 Thet_1580 ENOG4105EKQ RNA-directed DNA polymerase Thet_1582 ENOG4107S21 permease Thet_1585 ENOG4107RWR Sodium hydrogen exchanger Thet_1587 ENOG4105DG6 mannose-6-phosphate isomerase Thet_1588 ENOG4105D3A purine nucleoside phosphorylase DeoD-type Thet_1589 ENOG4105EGD dinuclear metal center protein, YbgI family Thet_1592 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Thet_1593 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) Thet_1594 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein Thet_1595 ENOG4105XZU Preprotein translocase, subunit SecG Thet_1597 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) Thet_1599 ENOG4105BZA Phosphoglycerate kinase Thet_1603 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 Thet_1604 ENOG410667J hydrolase Thet_1605 ENOG4105G5W regulator Fur family Thet_1606 ENOG41073R8 VanW family Thet_1607 ENOG4105CSM endonuclease III Thet_1608 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) Thet_1609 ENOG4105DAN ATP-dependent protease Thet_1612 ENOG410688J Ferredoxin Thet_1617 ENOG4105C22 threonyL-tRNA synthetase Thet_1619 ENOG4105EMS pseudouridine synthase Thet_1622 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase Thet_1624 ENOG4105D1H recombination factor protein RarA Thet_1632 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) Thet_1633 ENOG4105C59 p-type ATPase Thet_1657 ENOG4105EFC phage portal protein HK97 family Thet_1658 ENOG4105CAR Terminase, large subunit Thet_1664 ENOG4105EKQ RNA-directed DNA polymerase Thet_1666 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP Thet_1675 ENOG4105C2M dna polymerase I Thet_1688 ENOG4107XZC Restriction modification system DNA (Specificity Thet_1693 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) Thet_1696 ENOG4105WEF catalase Thet_1697 ENOG4108UIN ybak prolyl-trna synthetase associated region Thet_1698 ENOG4105C3R Methionine synthase Thet_1701 ENOG4107R76 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) Thet_1703 ENOG4108RCM Nitroreductase Thet_1704 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) Thet_1706 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) Thet_1708 ENOG4105E90 ABC transporter Thet_1709 ENOG4108IJ8 ABC transporter Thet_1711 ENOG4105UQX Mate efflux family protein Thet_1713 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) Thet_1716 ENOG4105CTQ phosphohexokinase Thet_1718 ENOG4105C0B DNA polymerase III (alpha subunit) Thet_1720 ENOG4105KRI phosphocarrier protein (HPr Thet_1723 ENOG4108IUK alpha amylase, catalytic Thet_1727 ENOG4105EG2 ABC transporter, permease Thet_1728 ENOG4105D56 permease protein Thet_1729 ENOG4107FKK extracellular solute-binding protein family 1 Thet_1734 ENOG4105D4A Cell wall formation (By similarity) Thet_1736 ENOG4105D78 K07001 NTE family protein Thet_1741 ENOG41060I7 thioesterase Superfamily protein Thet_1748 ENOG41082MP copper ion binding protein Thet_1749 ENOG4105C59 p-type ATPase Thet_1752 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) Thet_1753 ENOG4105CUZ uba thif-type nad fad binding protein Thet_1755 ENOG4105EB3 Histidine kinase Thet_1756 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Thet_1761 ENOG4105C6T cysteine synthase Thet_1763 ENOG410681U heavy metal transport detoxification protein Thet_1764 ENOG4105DQR SNARE associated Golgi Thet_1766 ENOG4105BZU Histidine kinase Thet_1769 ENOG4105G5W regulator Fur family Thet_1770 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Thet_1772 ENOG4105CE1 Ferrous iron transport protein b Thet_1774 ENOG4105CE1 Ferrous iron transport protein b Thet_1778 ENOG4108HWH (ABC) transporter Thet_1779 ENOG4105EHG Permease protein Thet_1781 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase Thet_1782 ENOG4107QW8 radical SAM domain protein Thet_1785 ENOG4105D1F ATP-binding protein Thet_1786 ENOG4105DSM The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity) Thet_1789 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Thet_1792 ENOG4108JVH Protein of unknown function DUF43 Thet_1793 ENOG4105ETE Transcriptional regulator (LacI family Thet_1794 ENOG4105D7K pfkb domain protein Thet_1795 ENOG4107R3K hydrolase Thet_1798 ENOG4107FKK extracellular solute-binding protein family 1 Thet_1801 ENOG4105CJN penicillin-binding protein Thet_1808 ENOG4105C8J )-transporter Thet_1809 ENOG4107SCA Formamidase (EC 3.5.1.49) Thet_1810 ENOG4105ID8 Transcriptional regulator, ARAC family Thet_1812 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component Thet_1813 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component Thet_1814 ENOG4107T3P ABC, transporter Thet_1817 ENOG4105C8I hydrolase, family 38 Thet_1818 ENOG4105CNT hydrolase family 2 Thet_1820 ENOG4105I1K ABC transporter Thet_1821 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component Thet_1824 ENOG4105E2R ROK family Thet_1825 ENOG4105CMR udp-glucose 4-epimerase Thet_1826 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) Thet_1827 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase Thet_1829 ENOG4105CMG Carbohydrate kinase Thet_1832 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) Thet_1833 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) Thet_1835 ENOG4105C5I Dehydrogenase Thet_1839 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) Thet_1849 ENOG4105NBF ammecr1 domain protein Thet_1852 ENOG4105CEY Amp-dependent synthetase and ligase Thet_1855 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) Thet_1859 ENOG4105CJN penicillin-binding protein Thet_1862 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) Thet_1863 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) Thet_1864 ENOG4108N5B 2-phosphosulfolactate phosphatase Thet_1867 ENOG4105DR5 peptidase Thet_1868 ENOG4105CRP Part of the ABC transporter FtsEX involved in Thet_1869 ENOG4105CAK Cell division ATP-binding protein ftsE Thet_1870 ENOG4107VHA regulatoR Thet_1873 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) Thet_1874 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) Thet_1875 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 Thet_1879 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) Thet_1887 ENOG4105CFG Acts as a chaperone (By similarity) Thet_1889 ENOG4105VDH Dihydroxyacetone kinase Thet_1891 ENOG4105CMT Dihydroxyacetone kinase Thet_1897 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) Thet_1898 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator Thet_1907 ENOG4108IGT Dipeptidase Thet_1908 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) Thet_1909 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase Thet_1912 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) Thet_1915 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) Thet_1916 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) Thet_1922 ENOG4105CK5 oxidoreductase Thet_1923 ENOG4105DKQ ROK family Thet_1925 ENOG4105CNN ABC, transporter Thet_1929 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) Thet_1934 ENOG4105CJ1 ABC, transporter Thet_1935 ENOG4105E2V Glycosyltransferase 36 Thet_1936 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B Thet_1937 ENOG4105CK5 oxidoreductase Thet_1938 ENOG4105DWV Homoserine O-trans-acetylase Thet_1940 ENOG4105D6E homoserine dehydrogenase Thet_1942 ENOG4105VCQ rubredoxin Thet_1944 ENOG4105DFD Na H antiporter Thet_1945 ENOG4105CTQ phosphohexokinase Thet_1947 ENOG4108IUS Transketolase Thet_1948 ENOG4108HHA Transketolase Thet_1949 ENOG4108JYZ YitT family Thet_1951 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) Thet_1953 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) Thet_1955 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) Thet_1956 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) Thet_1964 ENOG4105FDF Could be involved in DNA repair (By similarity) Thet_1965 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) Thet_1966 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme Thet_1967 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) Thet_1969 ENOG4105CEY Amp-dependent synthetase and ligase Thet_1972 ENOG4107RE7 phosphate butyryltransferase Thet_1978 ENOG4105CKM Branched-chain carboxylic acid kinase Thet_1979 ENOG4107RDP Dehydrogenase Thet_1980 ENOG4107RE7 phosphate butyryltransferase Thet_1981 ENOG4105CKM Branched-chain carboxylic acid kinase Thet_1983 ENOG4105C8B TIGR00159 family Thet_1989 ENOG4105C7R Atpase associated with various cellular activities aaa_3 Thet_1990 ENOG4107XGZ Hydrolase Thet_1997 ENOG4107SMJ Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) Thet_1999 ENOG4108JPZ Monovalent cation H antiporter subunit D Thet_2000 ENOG4108JPZ Monovalent cation H antiporter subunit D Thet_2004 ENOG4105KJM monovalent cation h antiporter subunit g Thet_2006 ENOG4105SC1 monovalent cation H antiporter subunit E Thet_2007 ENOG4105BZG amino acid carrier protein Thet_2008 ENOG4105D22 carbon starvation protein Thet_2011 ENOG4108YZ8 Superoxide reductase Thet_2014 ENOG4108UJD 30S ribosomal protein S9 Thet_2015 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) Thet_2016 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) Thet_2017 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) Thet_2018 ENOG4108JJB ABC transporter Thet_2019 ENOG4108JJB ABC transporter Thet_2020 ENOG4108ZT0 50S ribosomal protein l17 Thet_2021 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Thet_2022 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) Thet_2023 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) Thet_2024 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits Thet_2026 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) Thet_2029 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) Thet_2030 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) Thet_2031 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) Thet_2032 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) Thet_2033 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) Thet_2035 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) Thet_2036 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) Thet_2037 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits Thet_2038 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) Thet_2039 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) Thet_2040 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal Thet_2041 ENOG41082SA 50s ribosomal protein l29 Thet_2043 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) Thet_2044 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) Thet_2045 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) Thet_2046 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity Thet_2047 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) Thet_2048 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) Thet_2050 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) Thet_2051 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) Thet_2052 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) Thet_2054 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) Thet_2055 ENOG4105XPM ribosomal protein Thet_2061 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) Thet_2062 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) Thet_2063 ENOG410683Z Preprotein translocase SecE subunit Thet_2064 ENOG4105WDJ 50S ribosomal protein L33 Thet_2065 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) Thet_2067 ENOG4105M0M Tetracycline resistance protein Thet_2068 ENOG4105C2N RNA methyltransferase TrmH family group 3 Thet_2070 ENOG4105C8N cysteinyl-tRNA synthetase Thet_2071 ENOG4105D7W serine acetyltransferase Thet_2075 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) Thet_2077 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) Thet_2078 ENOG4105CTP PilT protein domain protein Thet_2080 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) Thet_2081 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Thet_2082 ENOG41066A3 ATP guanido phosphotransferase Thet_2083 ENOG4108Z0C Uvrb UvrC protein Thet_2086 ENOG4105C6K Malic enzyme Thet_2087 ENOG4105EKQ RNA-directed DNA polymerase Thet_2088 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) Thet_2089 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) Thet_2090 ENOG4108YRF PTS System Thet_2091 ENOG4105DM4 PTS System Thet_2092 ENOG4105DM4 PTS System Thet_2093 ENOG4105EMD TRANSCRIPTIONal Thet_2094 ENOG4105BZU Histidine kinase Thet_2100 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein Thet_2101 ENOG4105PW4 Sugar fermentation stimulation protein homolog Thet_2102 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase Thet_2103 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Thet_2104 ENOG4105EEI dihydropteroate synthase Thet_2105 ENOG4105EUJ GTP cyclohydrolase i Thet_2107 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) Thet_2113 ENOG4105E1K spore germination protein Thet_2114 ENOG4105GEU Spore germination protein Thet_2115 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) Thet_2116 ENOG4105FH5 Membrane Thet_2117 ENOG4107QSA Oxaloacetate decarboxylase Thet_2119 ENOG4107QX3 carboxylase Thet_2123 ENOG4105BZU Histidine kinase Thet_2125 ENOG4108UGV hypoxanthine phosphoribosyltransferase Thet_2126 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) Thet_2128 ENOG4105SX7 Transporter Thet_2133 ENOG4108T0W nitrous oxide maturation protein NosY Thet_2137 ENOG4105CPQ Dehydrogenase Thet_2144 ENOG4105C59 p-type ATPase Thet_2147 ENOG4105C6T cysteine synthase Thet_2148 ENOG4105C59 p-type ATPase Thet_2152 ENOG4105EB3 Histidine kinase Thet_2153 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Thet_2160 ENOG4107YGS glycoside hydrolase 15-related Thet_2162 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component Thet_2164 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component Thet_2165 ENOG4105CD3 dihydroorotase Thet_2166 ENOG4105E2R ROK family Thet_2169 ENOG4105EKQ RNA-directed DNA polymerase Thet_2170 ENOG4107RUY (E1 component), alpha subunit Thet_2189 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Thet_2205 ENOG4105DR5 peptidase Thet_2222 ENOG4108IMY Transcriptional regulator Thet_2228 ENOG4105D49 3-dehydroquinate synthase Thet_2229 ENOG41060GV RNA binding s1 domain protein Thet_2235 ENOG4105VYY sporulation protein yabp Thet_2236 ENOG4105JFG SpoIID LytB domain protein Thet_2237 ENOG41082I2 s4 domain protein Thet_2238 ENOG4105K70 DNA-binding protein Thet_2239 ENOG4108IY2 MazG family Thet_2241 ENOG4107SFI Major Facilitator superfamily Thet_2242 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) Thet_2243 ENOG4108IJ0 Aspartate ammonia-lyase Thet_2245 ENOG4105MAX Superoxide reductase Thet_2253 ENOG4105EAH synthase Thet_2257 ENOG41090A1 ferritin Thet_2261 ENOG4105CH7 arginosuccinase Thet_2264 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain Thet_2265 ENOG4105C8Y Acetylornithine aminotransferase Thet_2267 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) Thet_2273 ENOG4105CDJ oxidoreductase FAD NAD(P)-binding domain protein Thet_2274 ENOG4105BZ8 glutamate synthase Thet_2275 ENOG4105DCG PHP domain protein Thet_2277 ENOG4105DA5 (ABC) transporter Thet_2278 ENOG41069JR Thet_2281 ENOG4105EMN RNA polymerase sigma factor Thet_2291 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic Thet_2292 ENOG4105YVM Phosphoesterase, PA-phosphatase related Thet_2293 ENOG4105N67 Proton-coupled thiamine transporter YuaJ Thet_2294 ENOG4105BZ1 (ABC) transporter Thet_2296 ENOG41067TZ transcriptional regulator, MarR family Thet_2299 ENOG4108EKI Dehydrogenase Thet_2301 ENOG4105CPC Aldo Keto reductase Thet_2304 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Thet_2305 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Thet_2307 ENOG4108JQ7 (ABC) transporter Thet_2310 ENOG4105CM2 brancheD-chain amino acid aminotransferase Thet_2311 ENOG4105CRQ synthase (Component I) Thet_2313 ENOG4107WCI zn-dependent hydrolase of the beta-lactamase fold-like protein Thet_2314 ENOG4105C75 arginyL-tRNA synthetase Thet_2316 ENOG4105CPF Cell wall formation (By similarity) Thet_2317 ENOG4105XEW small acid-soluble spore protein Thet_2318 ENOG4105MSI germination protein ypeb Thet_2320 ENOG4108ZXQ stage ii sporulation protein r Thet_2321 ENOG4108Q5U germination protein, ger(x)c family Thet_2322 ENOG4108Q8B Spore germination protein Thet_2326 ENOG4105DRR Transcriptional regulator, GntR family Thet_2329 ENOG4105W42 Veg protein Thet_2330 ENOG4105XFA sporulation peptidase YabG Thet_2331 ENOG4108M14 stage v sporulation protein t Thet_2332 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) Thet_2333 ENOG4108JA2 transcriptioN-repair coupling factor Thet_2336 ENOG4105C0H protease Thet_2337 ENOG4105BZU Histidine kinase Thet_2338 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Thet_2339 ENOG4105C5T Phosphoribosyl pyrophosphate synthase Thet_2340 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) Thet_2342 ENOG4105DFT pur operon repressor Thet_2343 ENOG4105DFU Cell wall formation (By similarity) Thet_2344 ENOG4105ETE Transcriptional regulator (LacI family Thet_2346 ENOG4105VN1 Heat shock protein Thet_2348 ENOG4105DM4 PTS System Thet_2349 ENOG4105DM4 PTS System Thet_2350 ENOG4105DE4 1-phosphofructokinase Thet_2351 ENOG4105E98 transcriptional regulator DeoR family Thet_2353 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) Thet_2356 ENOG4105C5R Aminotransferase Thet_2358 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) Thet_2359 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) Thet_2361 ENOG41090I5 UPF0735 ACT domain-containing protein Thet_2362 ENOG4105Q2H domain protein Thet_2364 ENOG4105ZHF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) Thet_2365 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) Thet_2367 ENOG4105EC3 peptidase S51, dipeptidase E Thet_2376 ENOG4107YH3 SUF system FeS assembly protein, NifU family Thet_2379 ENOG4105DIW FeS assembly protein SUFB Thet_2380 ENOG4105C3K feS assembly ATPase SufC Thet_2381 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) Thet_2386 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) Thet_2391 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) Thet_2393 ENOG4105DR5 peptidase Thet_2395 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) Thet_2396 ENOG4105CD8 aminopeptidase N Thet_2399 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 Thet_2402 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis Thet_2403 ENOG4105DZ0 fad dependent oxidoreductase Thet_2404 ENOG4105C8Q Methyl-accepting chemotaxis Thet_2406 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase Thet_2407 ENOG4105DPN Oligoendopeptidase f Thet_2410 ENOG4105M56 Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) Thet_2413 ENOG4105KXQ Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) Thet_2419 ENOG4105C2W permease Thet_2436 ENOG4105CDU Replicative dna helicase Thet_2437 ENOG4105K9Q Binds to the 23S rRNA (By similarity) Thet_2438 ENOG4105BZR domain protein Thet_2441 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) Thet_2442 ENOG4108UUM single-stranded DNA-binding protein Thet_2443 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) Thet_2444 ENOG4105VDK protein, conserved in bacteria Thet_2445 ENOG4105D8X mechanosensitive ion channel Thet_2446 ENOG4108ZDA Sporulation protein YyaC Thet_2448 ENOG4105DDG Cyanophycinase Thet_2449 ENOG4105CBD Diacylglycerol kinase Thet_2451 ENOG4105C9B Cysteine desulfurase Thet_2452 ENOG4105FA0 parb-like partition protein Thet_2453 ENOG4107QJE Chromosome Partitioning Protein Thet_2454 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) Thet_2457 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) Thet_2459 ENOG4108Z7S Single-stranded nucleic acid binding R3H domain-containing protein Thet_2460 ENOG4107R4E Membrane Thet_2461 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) Thet_2462 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) Thet_2463 ENOG4105VG0 50S ribosomal protein l34