locus-tag	class	description
Thet_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Thet_0002	COG0592	DNA-directed DNA polymerase activity
Thet_0003	COG2501	S4 domain
Thet_0007	COG3442	glutamine amidotransferase
Thet_0010	COG0187	DNA topoisomerase II activity
Thet_0011	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Thet_0012	COG1902	pentaerythritol trinitrate reductase activity
Thet_0013	COG0440	acetolactate synthase activity
Thet_0015	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Thet_0017	COG0066	3-isopropylmalate dehydratase activity
Thet_0018	COG0473	3-isopropylmalate dehydrogenase activity
Thet_0019	COG0129	dihydroxy-acid dehydratase activity
Thet_0020	COG0028	Belongs to the TPP enzyme family
Thet_0025	COG0628	permease
Thet_0029	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Thet_0033	COG2199	diguanylate cyclase activity
Thet_0033	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Thet_0034	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Thet_0037	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Thet_0038	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Thet_0043	COG1028	Short-chain dehydrogenase reductase Sdr
Thet_0044	COG1187	pseudouridine synthase activity
Thet_0055	COG4166	transmembrane transport
Thet_0056	COG0601	transmembrane transport
Thet_0058	COG0444	Belongs to the ABC transporter superfamily
Thet_0059	COG4608	Belongs to the ABC transporter superfamily
Thet_0062	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Thet_0063	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Thet_0064	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Thet_0067	COG1181	Belongs to the D-alanine--D-alanine ligase family
Thet_0068	COG1028	Short-chain dehydrogenase reductase Sdr
Thet_0070	COG3103	Sh3 type 3 domain protein
Thet_0070	COG0366	Alpha amylase catalytic
Thet_0071	COG0037	tRNA processing
Thet_0072	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Thet_0074	COG1573	uracil-dna glycosylase
Thet_0076	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Thet_0078	COG0583	DNA-binding transcription factor activity
Thet_0079	COG2391	methyltransferase activity
Thet_0081	COG2391	methyltransferase activity
Thet_0084	COG1940	carbohydrate kinase activity
Thet_0085	COG0519	Catalyzes the synthesis of GMP from XMP
Thet_0087	COG1982	Orn Lys Arg decarboxylase major
Thet_0088	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Thet_0089	COG3870	Protein conserved in bacteria
Thet_0091	COG0470	DNA polymerase III
Thet_0092	COG1774	PSP1 C-terminal conserved region
Thet_0093	COG2235	arginine
Thet_0094	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Thet_0095	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Thet_0097	COG2002	toxin-antitoxin pair type II binding
Thet_0098	COG2715	membrane protein required for spore maturation
Thet_0099	COG0700	Nucleoside recognition
Thet_0100	COG0617	tRNA 3'-terminal CCA addition
Thet_0101	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Thet_0101	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Thet_0102	COG0084	hydrolase, TatD family'
Thet_0103	COG3584	3D domain protein
Thet_0103	COG3583	domain protein
Thet_0104	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Thet_0109	COG1191	sigma factor activity
Thet_0110	COG0489	protein tyrosine kinase activity
Thet_0110	COG2151	metal-sulfur cluster biosynthetic enzyme
Thet_0113	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Thet_0115	COG4656	Part of a membrane complex involved in electron transport
Thet_0116	COG4658	electron transport chain
Thet_0117	COG4659	FMN binding
Thet_0118	COG4660	Part of a membrane complex involved in electron transport
Thet_0119	COG4657	Part of a membrane complex involved in electron transport
Thet_0120	COG1245	4Fe-4S binding domain
Thet_0120	COG2878	Part of a membrane complex involved in electron transport
Thet_0122	COG0745	RESPONSE REGULATOR receiver
Thet_0124	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Thet_0125	COG0254	rRNA binding
Thet_0126	COG1435	thymidine kinase activity
Thet_0127	COG3872	metal-dependent enzyme
Thet_0131	COG0009	L-threonylcarbamoyladenylate synthase
Thet_0132	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Thet_0133	COG0698	ribose 5-phosphate isomerase
Thet_0134	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Thet_0138	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Thet_0139	COG0686	Belongs to the AlaDH PNT family
Thet_0141	COG2385	sporulation resulting in formation of a cellular spore
Thet_0143	COG1609	Transcriptional regulator
Thet_0145	COG4786	Flagellar basal body rod
Thet_0156	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Thet_0156	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Thet_0159	COG3775	system Galactitol-specific IIC component
Thet_0163	COG4948	Mandelate Racemase Muconate Lactonizing
Thet_0164	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Thet_0165	COG0800	Aldolase
Thet_0166	COG2814	Major facilitator Superfamily
Thet_0167	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Thet_0167	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Thet_0168	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thet_0170	COG3716	PTS system mannose fructose sorbose family IID component
Thet_0171	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Thet_0172	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Thet_0173	COG0800	Aldolase
Thet_0174	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Thet_0175	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Thet_0176	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Thet_0177	COG0569	domain protein
Thet_0180	COG0778	Nitroreductase
Thet_0183	COG0583	DNA-binding transcription factor activity
Thet_0190	COG1070	Carbohydrate kinase
Thet_0191	COG4213	ABC transporter substrate-binding protein
Thet_0192	COG3344	reverse transcriptase
Thet_0194	COG1129	ABC transporter
Thet_0195	COG4214	carbohydrate transport
Thet_0198	COG1609	Transcriptional regulator
Thet_0199	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Thet_0200	COG1869	D-ribose catabolic process
Thet_0201	COG1129	ABC transporter
Thet_0202	COG1172	Belongs to the binding-protein-dependent transport system permease family
Thet_0203	COG1879	ABC-type sugar transport system periplasmic component
Thet_0204	COG3344	reverse transcriptase
Thet_0206	COG1737	Transcriptional regulator
Thet_0207	COG2190	(PTS) system
Thet_0208	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Thet_0208	COG1263	PTS System
Thet_0211	COG2188	Transcriptional regulator
Thet_0216	COG1735	metal-dependent hydrolase with the TIM-barrel fold
Thet_0217	COG0626	cystathionine gamma-synthase activity
Thet_0218	COG3457	Alanine racemase
Thet_0219	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Thet_0220	COG1472	Belongs to the glycosyl hydrolase 3 family
Thet_0223	COG0436	Aminotransferase
Thet_0224	COG1522	sequence-specific DNA binding
Thet_0226	COG1918	ferrous iron import across plasma membrane
Thet_0226	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Thet_0227	COG1122	ATPase activity
Thet_0228	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Thet_0229	COG0310	cobalt ion transport
Thet_0230	COG0310	cobalt ion transport
Thet_0231	COG0864	Transcriptional regulator
Thet_0233	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Thet_0236	COG0534	Mate efflux family protein
Thet_0237	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Thet_0238	COG1136	(ABC) transporter
Thet_0239	COG1136	(ABC) transporter
Thet_0239	COG0577	efflux transmembrane transporter activity
Thet_0240	COG0179	Fumarylacetoacetate (FAA) hydrolase
Thet_0242	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
Thet_0244	COG0420	3'-5' exonuclease activity
Thet_0245	COG0419	ATPase involved in DNA repair
Thet_0247	COG0450	alkyl hydroperoxide reductase
Thet_0252	COG0297	glycogen (starch) synthase activity
Thet_0256	COG0039	L-malate dehydrogenase activity
Thet_0262	COG1980	fructose-bisphosphate aldolase activity
Thet_0262	COG1980	fructose-bisphosphate aldolase activity
Thet_0264	COG2972	Histidine kinase
Thet_0265	COG2197	response regulator
Thet_0266	COG4213	ABC transporter substrate-binding protein
Thet_0267	COG4213	ABC transporter substrate-binding protein
Thet_0268	COG1129	ABC transporter
Thet_0269	COG4214	carbohydrate transport
Thet_0270	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Thet_0271	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Thet_0274	COG0095	Lipoate-protein ligase
Thet_0275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Thet_0277	COG0436	Aminotransferase
Thet_0278	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thet_0279	COG3037	sugar-specific permease SgaT UlaA
Thet_0283	COG1979	alcohol dehydrogenase
Thet_0287	COG0640	Transcriptional regulator
Thet_0290	COG1309	transcriptional regulator
Thet_0293	COG1924	4 iron, 4 sulfur cluster binding
Thet_0295	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Thet_0296	COG0390	transport system, permease component
Thet_0297	COG0495	leucyl-tRNA aminoacylation
Thet_0298	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
Thet_0300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Thet_0300	COG1522	sequence-specific DNA binding
Thet_0301	COG2313	pseudouridylate synthase activity
Thet_0303	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Thet_0303	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Thet_0307	COG1447	Phosphotransferase system cellobiose-specific component IIA
Thet_0308	COG1486	melibiose metabolic process
Thet_0309	COG2723	6-phospho-beta-galactosidase activity
Thet_0310	COG2213	PTS system mannitol-specific
Thet_0311	COG3711	transcriptional antiterminator
Thet_0311	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thet_0314	COG0737	Belongs to the 5'-nucleotidase family
Thet_0315	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Thet_0316	COG0730	response to heat
Thet_0318	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Thet_0319	COG1121	(ABC) transporter
Thet_0320	COG0803	Belongs to the bacterial solute-binding protein 9 family
Thet_0321	COG0735	belongs to the Fur family
Thet_0322	COG0714	Associated with various cellular activities
Thet_0325	COG1704	LemA family
Thet_0329	COG2221	Nitrite and sulphite reductase 4Fe-4S
Thet_0332	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Thet_0333	COG0822	iron-sulfur transferase activity
Thet_0336	COG0116	Belongs to the methyltransferase superfamily
Thet_0339	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Thet_0340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Thet_0341	COG1120	ATPase activity
Thet_0342	COG1797	cobyrinic acid a,c-diamide synthase activity
Thet_0347	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Thet_0356	COG2875	Belongs to the precorrin methyltransferase family
Thet_0360	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Thet_0363	COG0113	porphobilinogen synthase activity
Thet_0364	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Thet_0365	COG0310	cobalt ion transport
Thet_0368	COG1122	ATPase activity
Thet_0373	COG4555	ABC transporter
Thet_0383	COG1121	(ABC) transporter
Thet_0385	COG4555	ABC transporter
Thet_0386	COG1668	transmembrane transport
Thet_0391	COG1131	(ABC) transporter
Thet_0393	COG4566	intracellular signal transduction
Thet_0396	COG1131	(ABC) transporter
Thet_0407	COG1121	(ABC) transporter
Thet_0409	COG4555	ABC transporter
Thet_0410	COG1668	transmembrane transport
Thet_0424	COG1363	Peptidase, m42
Thet_0430	COG3344	reverse transcriptase
Thet_0432	COG2199	diguanylate cyclase activity
Thet_0432	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Thet_0436	COG0840	transmembrane signaling receptor activity
Thet_0438	COG1228	amidohydrolase
Thet_0441	COG1486	melibiose metabolic process
Thet_0444	COG1653	transport
Thet_0445	COG2972	Histidine kinase
Thet_0446	COG2207	Transcriptional regulator
Thet_0446	COG4753	response regulator
Thet_0447	COG3404	Formiminotransferase-cyclodeaminase
Thet_0448	COG1744	ABC transporter substrate-binding protein PnrA-like
Thet_0454	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Thet_0456	COG0840	transmembrane signaling receptor activity
Thet_0458	COG1263	PTS System
Thet_0458	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Thet_0458	COG2190	(PTS) system
Thet_0459	COG2190	(PTS) system
Thet_0460	COG3711	transcriptional antiterminator
Thet_0461	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Thet_0470	COG2081	HI0933 family
Thet_0471	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Thet_0473	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Thet_0475	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
Thet_0479	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Thet_0480	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Thet_0483	COG2323	membrane
Thet_0484	COG0561	phosphatase activity
Thet_0486	COG1609	Transcriptional regulator
Thet_0487	COG0745	RESPONSE REGULATOR receiver
Thet_0488	COG5002	protein histidine kinase activity
Thet_0492	COG1592	Rubrerythrin
Thet_0493	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Thet_0494	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Thet_0495	COG1040	competence protein
Thet_0499	COG1256	bacterial-type flagellum assembly
Thet_0499	COG4786	Flagellar basal body rod
Thet_0500	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Thet_0502	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
Thet_0503	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Thet_0509	COG0367	asparagine synthase
Thet_0512	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Thet_0513	COG1516	flagellar protein fliS
Thet_0518	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Thet_0519	COG0765	amino acid transport
Thet_0525	COG1827	regulation of RNA biosynthetic process
Thet_0527	COG0653	protein targeting
Thet_0529	COG2183	response to ionizing radiation
Thet_0531	COG0398	Pfam SNARE associated Golgi protein
Thet_0533	COG2235	arginine
Thet_0534	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Thet_0535	COG0549	Belongs to the carbamate kinase family
Thet_0537	COG3344	reverse transcriptase
Thet_0538	COG0802	atpase or kinase
Thet_0539	COG1214	PFAM Peptidase M22, glycoprotease
Thet_0541	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Thet_0543	COG0488	(ABC) transporter
Thet_0548	COG3279	Response regulator of the LytR AlgR family
Thet_0549	COG3290	protein histidine kinase activity
Thet_0554	COG0493	'glutamate synthase
Thet_0557	COG1811	Na channel or pump
Thet_0559	COG1404	Belongs to the peptidase S8 family
Thet_0565	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Thet_0566	COG0459	protein refolding
Thet_0567	COG0517	IMP dehydrogenase activity
Thet_0567	COG0516	GMP reductase activity
Thet_0568	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Thet_0568	COG0519	Catalyzes the synthesis of GMP from XMP
Thet_0569	COG2252	PERMEase
Thet_0570	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Thet_0571	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Thet_0572	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Thet_0573	COG0047	phosphoribosylformylglycinamidine synthase activity
Thet_0575	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Thet_0577	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Thet_0579	COG0151	Belongs to the GarS family
Thet_0581	COG1473	amidohydrolase
Thet_0582	COG2244	polysaccharide biosynthetic process
Thet_0584	COG3711	transcriptional antiterminator
Thet_0586	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Thet_0587	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Thet_0588	COG1447	Phosphotransferase system cellobiose-specific component IIA
Thet_0589	COG4496	protein, YerC YecD
Thet_0590	COG0210	DNA helicase
Thet_0592	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Thet_0599	COG4166	transmembrane transport
Thet_0600	COG0601	transmembrane transport
Thet_0601	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Thet_0602	COG0444	Belongs to the ABC transporter superfamily
Thet_0603	COG4608	Belongs to the ABC transporter superfamily
Thet_0605	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Thet_0609	COG0004	ammonium transporteR
Thet_0610	COG0347	Belongs to the P(II) protein family
Thet_0612	COG0505	Belongs to the CarA family
Thet_0613	COG0067	glutamate synthase
Thet_0614	COG0069	glutamate synthase activity
Thet_0614	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Thet_0615	COG0437	4 iron, 4 sulfur cluster binding
Thet_0618	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Thet_0622	COG0351	phosphomethylpyrimidine kinase
Thet_0623	COG0352	thiamine-phosphate diphosphorylase activity
Thet_0628	COG0704	Plays a role in the regulation of phosphate uptake
Thet_0629	COG0410	ABC transporter
Thet_0632	COG0544	peptidyl-prolyl cis-trans isomerase activity
Thet_0633	COG0740	serine-type endopeptidase activity
Thet_0635	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Thet_0636	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Thet_0638	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Thet_0638	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Thet_0639	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Thet_0640	COG1116	anion transmembrane transporter activity
Thet_0641	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Thet_0643	COG2239	Acts as a magnesium transporter
Thet_0650	COG0438	transferase activity, transferring glycosyl groups
Thet_0652	COG0438	transferase activity, transferring glycosyl groups
Thet_0654	COG0438	transferase activity, transferring glycosyl groups
Thet_0655	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Thet_0667	COG1401	restriction endodeoxyribonuclease activity
Thet_0670	COG2161	toxin-antitoxin pair type II binding
Thet_0675	COG1704	LemA family
Thet_0676	COG0622	Phosphoesterase
Thet_0677	COG4989	oxidoreductase activity
Thet_0681	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Thet_0683	COG1914	H( )-stimulated, divalent metal cation uptake system
Thet_0694	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
Thet_0695	COG0250	Participates in transcription elongation, termination and antitermination
Thet_0697	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Thet_0698	COG3944	biosynthesis protein
Thet_0699	COG0489	protein tyrosine kinase activity
Thet_0701	COG1316	TRANSCRIPTIONal
Thet_0702	COG3949	Membrane
Thet_0704	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Thet_0706	COG0105	UTP biosynthetic process
Thet_0707	COG2814	Major facilitator Superfamily
Thet_0710	COG3344	reverse transcriptase
Thet_0713	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Thet_0714	COG1606	tRNA processing
Thet_0715	COG1691	(AIR) carboxylase
Thet_0716	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Thet_0717	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Thet_0718	COG5002	protein histidine kinase activity
Thet_0719	COG0745	RESPONSE REGULATOR receiver
Thet_0724	COG0525	valine-tRNA ligase activity
Thet_0726	COG0285	dihydrofolate synthase activity
Thet_0731	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Thet_0732	COG1609	Transcriptional regulator
Thet_0735	COG1175	transmembrane transport
Thet_0736	COG0395	ABC-type sugar transport system, permease component
Thet_0737	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Thet_0740	COG0395	ABC-type sugar transport system, permease component
Thet_0743	COG1404	Belongs to the peptidase S8 family
Thet_0744	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Thet_0744	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Thet_0745	COG3773	Cell wall hydrolase
Thet_0745	COG3409	Peptidoglycan-binding domain 1 protein
Thet_0748	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Thet_0750	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Thet_0751	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Thet_0752	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Thet_0754	COG1132	(ABC) transporter
Thet_0755	COG1132	(ABC) transporter
Thet_0759	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Thet_0760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Thet_0762	COG0739	heme binding
Thet_0765	COG2986	histidine ammonia-lyase
Thet_0774	COG4475	Protein of unknown function (DUF436)
Thet_0779	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Thet_0779	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Thet_0780	COG0237	dephospho-CoA kinase activity
Thet_0781	COG0741	lytic transglycosylase activity
Thet_0784	COG0791	NLP P60 protein
Thet_0786	COG0741	lytic transglycosylase activity
Thet_0790	COG2878	Part of a membrane complex involved in electron transport
Thet_0794	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Thet_0794	COG4191	Histidine kinase
Thet_0799	COG0424	maF-like protein
Thet_0800	COG2003	Belongs to the UPF0758 family
Thet_0801	COG1077	Cell shape determining protein MreB Mrl
Thet_0804	COG0768	penicillin binding
Thet_0805	COG0850	regulation of cytokinetic process
Thet_0806	COG2894	cell division
Thet_0807	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Thet_0808	COG0772	Belongs to the SEDS family
Thet_0809	COG1803	Methylglyoxal synthase
Thet_0810	COG0739	heme binding
Thet_0811	COG1994	Peptidase M50
Thet_0811	COG0517	IMP dehydrogenase activity
Thet_0814	COG1530	ribonuclease E activity
Thet_0815	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Thet_0816	COG4708	membrane
Thet_0818	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Thet_0820	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Thet_0822	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Thet_0823	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Thet_0824	COG1713	HD superfamily hydrolase involved in NAD metabolism
Thet_0825	COG0799	negative regulation of ribosome biogenesis
Thet_0829	COG0367	asparagine synthase
Thet_0830	COG1686	Belongs to the peptidase S11 family
Thet_0831	COG1555	photosystem II stabilization
Thet_0831	COG1596	polysaccharide export
Thet_0832	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Thet_0836	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Thet_0840	COG4720	Psort location CytoplasmicMembrane, score
Thet_0842	COG1234	tRNA 3'-trailer cleavage
Thet_0845	COG0268	Binds directly to 16S ribosomal RNA
Thet_0847	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Thet_0853	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Thet_0855	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Thet_0857	COG0484	heat shock protein binding
Thet_0859	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Thet_0860	COG3830	Belongs to the UPF0237 family
Thet_0863	COG0701	Predicted permease
Thet_0865	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Thet_0866	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Thet_0868	COG1956	GAF domain-containing protein
Thet_0869	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Thet_0871	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Thet_0872	COG1278	Cold shock
Thet_0873	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Thet_0874	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Thet_0875	COG0745	RESPONSE REGULATOR receiver
Thet_0878	COG4399	Belongs to the UPF0754 family
Thet_0879	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Thet_0882	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Thet_0885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Thet_0886	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Thet_0887	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Thet_0887	COG0072	phenylalanine-tRNA ligase activity
Thet_0889	COG0826	peptidase U32
Thet_0890	COG1193	negative regulation of DNA recombination
Thet_0891	COG1683	Conserved Protein
Thet_0894	COG2197	response regulator
Thet_0895	COG1362	aminopeptidase activity
Thet_0899	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Thet_0901	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Thet_0903	COG0459	protein refolding
Thet_0904	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Thet_0905	COG0022	dehydrogenase e1 component
Thet_0906	COG3199	ATP-NAD kinase
Thet_0907	COG0508	dehydrogenase complex catalyzes the overall conversion of
Thet_0910	COG3344	reverse transcriptase
Thet_0915	COG0012	GTP binding
Thet_0917	COG0612	Peptidase, M16
Thet_0918	COG0612	Peptidase, M16
Thet_0921	COG3116	cell division
Thet_0922	COG0768	penicillin binding
Thet_0923	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Thet_0924	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Thet_0925	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Thet_0927	COG0772	Belongs to the SEDS family
Thet_0928	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Thet_0929	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Thet_0932	COG3856	small basic protein
Thet_0933	COG0849	cell division
Thet_0934	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Thet_0936	COG1191	sigma factor activity
Thet_0937	COG1191	sigma factor activity
Thet_0938	COG1873	PFAM PRC-barrel domain
Thet_0940	COG0745	RESPONSE REGULATOR receiver
Thet_0941	COG5002	protein histidine kinase activity
Thet_0942	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Thet_0943	COG0573	inorganic phosphate transmembrane transporter activity
Thet_0944	COG0581	inorganic phosphate transmembrane transporter activity
Thet_0945	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Thet_0946	COG0704	Plays a role in the regulation of phosphate uptake
Thet_0959	COG0745	RESPONSE REGULATOR receiver
Thet_0962	COG0531	amino acid
Thet_0963	COG0653	protein targeting
Thet_0965	COG1131	(ABC) transporter
Thet_0971	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
Thet_0977	COG2972	Histidine kinase
Thet_0978	COG2197	response regulator
Thet_0980	COG1971	Probably functions as a manganese efflux pump
Thet_0981	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Thet_0988	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Thet_0989	COG4869	propanediol catabolic process
Thet_0990	COG4820	ethanolamine utilization protein (EutJ)
Thet_0992	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
Thet_0994	COG1012	belongs to the aldehyde dehydrogenase family
Thet_0996	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Thet_0997	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Thet_0998	COG4810	utilization protein
Thet_0999	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Thet_1000	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Thet_1001	COG1454	alcohol dehydrogenase
Thet_1002	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Thet_1003	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Thet_1004	COG1120	ATPase activity
Thet_1010	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Thet_1011	COG3959	Transketolase, thiamine diphosphate binding domain
Thet_1012	COG3958	Transketolase
Thet_1013	COG0698	ribose 5-phosphate isomerase
Thet_1015	COG0613	PHP domain protein
Thet_1017	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Thet_1020	COG1012	belongs to the aldehyde dehydrogenase family
Thet_1025	COG2376	Dihydroxyacetone kinase
Thet_1027	COG1461	Dihydroxyacetone kinase
Thet_1034	COG0632	four-way junction helicase activity
Thet_1039	COG3835	regulator
Thet_1040	COG1929	Belongs to the glycerate kinase type-1 family
Thet_1041	COG2610	gluconate transmembrane transporter activity
Thet_1045	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Thet_1046	COG1799	cell septum assembly
Thet_1048	COG2302	S4 RNA-binding domain
Thet_1049	COG3599	regulation of cell shape
Thet_1051	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Thet_1052	COG0402	S-adenosylhomocysteine deaminase activity
Thet_1053	COG0235	Class ii aldolase
Thet_1054	COG2188	Transcriptional regulator
Thet_1056	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Thet_1057	COG1122	ATPase activity
Thet_1059	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Thet_1068	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Thet_1068	COG0512	Glutamine amidotransferase of anthranilate synthase
Thet_1069	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Thet_1074	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Thet_1075	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Thet_1076	COG0626	cystathionine gamma-synthase activity
Thet_1083	COG1703	isobutyryl-CoA mutase activity
Thet_1084	COG0346	lactoylglutathione lyase activity
Thet_1086	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
Thet_1089	COG1595	DNA-templated transcription, initiation
Thet_1090	COG0778	Nitroreductase
Thet_1093	COG1970	mechanosensitive ion channel activity
Thet_1107	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Thet_1115	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Thet_1116	COG0564	pseudouridine synthase activity
Thet_1118	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Thet_1119	COG0540	Belongs to the ATCase OTCase family
Thet_1120	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Thet_1122	COG0543	2 iron, 2 sulfur cluster binding
Thet_1124	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Thet_1127	COG0037	tRNA processing
Thet_1130	COG2011	ABC-type metal ion transport system permease component
Thet_1131	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Thet_1135	COG2814	Major facilitator Superfamily
Thet_1136	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Thet_1137	COG1561	YicC-like family, N-terminal region
Thet_1139	COG0194	GDP metabolic process
Thet_1141	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Thet_1142	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Thet_1145	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Thet_1147	COG2738	Putative neutral zinc metallopeptidase
Thet_1148	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Thet_1148	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Thet_1149	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Thet_1150	COG0631	protein serine/threonine phosphatase activity
Thet_1151	COG2815	serine threonine protein kinase
Thet_1151	COG0515	serine threonine protein kinase
Thet_1152	COG1162	GTPase activity
Thet_1153	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Thet_1157	COG1302	Protein conserved in bacteria
Thet_1158	COG1461	Dihydroxyacetone kinase
Thet_1159	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Thet_1160	COG1307	EDD domain protein, DegV family
Thet_1163	COG0742	ribosomal rna small subunit methyltransferase
Thet_1164	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Thet_1166	COG3314	Sporulation integral membrane protein YlbJ
Thet_1168	COG0280	phosphate acetyltransferase
Thet_1169	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Thet_1170	COG1399	metal-binding, possibly nucleic acid-binding protein
Thet_1171	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Thet_1172	COG2030	dehydratase
Thet_1174	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Thet_1175	COG2070	2-Nitropropane dioxygenase
Thet_1176	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Thet_1177	COG1028	Short-chain dehydrogenase reductase Sdr
Thet_1178	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Thet_1179	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Thet_1180	COG0571	ribonuclease III activity
Thet_1182	COG2359	stage V sporulation protein S
Thet_1185	COG0552	protein localization to endoplasmic reticulum
Thet_1186	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
Thet_1187	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Thet_1189	COG1837	Belongs to the UPF0109 family
Thet_1190	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Thet_1191	COG0336	Belongs to the RNA methyltransferase TrmD family
Thet_1192	COG0335	large ribosomal subunit rRNA binding
Thet_1194	COG0606	chelatase, subunit chli
Thet_1195	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Thet_1196	COG0180	Tryptophanyl-tRNA synthetase
Thet_1197	COG0792	nuclease activity
Thet_1198	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Thet_1199	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Thet_1199	COG0758	DNA mediated transformation
Thet_1200	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Thet_1204	COG1815	bacterial-type flagellum-dependent cell motility
Thet_1206	COG1677	Flagellar hook-basal body complex protein FliE
Thet_1207	COG1766	The M ring may be actively involved in energy transduction
Thet_1208	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Thet_1210	COG1157	protein secretion by the type III secretion system
Thet_1214	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Thet_1217	COG1582	Flagellar protein (FlbD)
Thet_1219	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Thet_1220	COG1776	CheC inhibitor of MCP methylation
Thet_1220	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Thet_1221	COG2201	protein-glutamate methylesterase activity
Thet_1223	COG1338	Plays a role in the flagellum-specific transport system
Thet_1224	COG1987	bacterial-type flagellum assembly
Thet_1225	COG1684	flagellar biosynthetic protein fliR
Thet_1226	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Thet_1227	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Thet_1228	COG1419	protein localization to endoplasmic reticulum
Thet_1229	COG0455	bacterial-type flagellum organization
Thet_1231	COG2201	protein-glutamate methylesterase activity
Thet_1232	COG0643	Histidine kinase
Thet_1232	COG2198	Histidine kinase
Thet_1233	COG0835	chemotaxis
Thet_1234	COG1776	CheC inhibitor of MCP methylation
Thet_1235	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Thet_1236	COG1191	sigma factor activity
Thet_1240	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Thet_1241	COG0528	UMP kinase activity
Thet_1242	COG0233	cytoplasmic translational termination
Thet_1244	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Thet_1245	COG4589	Belongs to the CDS family
Thet_1247	COG0750	zinc metalloprotease
Thet_1248	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Thet_1250	COG2176	DNA-directed DNA polymerase activity
Thet_1252	COG0195	Participates in both transcription termination and antitermination
Thet_1253	COG2740	Nucleic-acid-binding protein implicated in transcription termination
Thet_1256	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Thet_1258	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Thet_1259	COG0196	riboflavin kinase activity
Thet_1260	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Thet_1262	COG0726	polysaccharide deacetylase
Thet_1263	COG0612	Peptidase, M16
Thet_1264	COG0756	dUTP diphosphatase activity
Thet_1266	COG0527	aspartate kinase activity
Thet_1267	COG0740	serine-type endopeptidase activity
Thet_1269	COG1674	ftsk spoiiie
Thet_1271	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Thet_1273	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Thet_1274	COG2137	regulation of response to DNA damage stimulus
Thet_1276	COG1692	metallophosphoesterase
Thet_1277	COG2359	stage V sporulation protein S
Thet_1278	COG0613	PHP domain protein
Thet_1280	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Thet_1281	COG0464	growth
Thet_1282	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
Thet_1283	COG4974	Belongs to the 'phage' integrase family
Thet_1284	COG0328	RNA-DNA hybrid ribonuclease activity
Thet_1285	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Thet_1286	COG1923	regulation of RNA biosynthetic process
Thet_1287	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Thet_1289	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Thet_1291	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Thet_1292	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Thet_1294	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Thet_1296	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Thet_1299	COG2081	HI0933 family
Thet_1300	COG0406	alpha-ribazole phosphatase activity
Thet_1303	COG4336	lyase activity
Thet_1304	COG1984	allophanate hydrolase subunit 2
Thet_1305	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Thet_1306	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Thet_1307	COG1914	H( )-stimulated, divalent metal cation uptake system
Thet_1309	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Thet_1314	COG1013	pyruvate-flavodoxin oxidoreductase activity
Thet_1315	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Thet_1315	COG0674	pyruvate-flavodoxin oxidoreductase activity
Thet_1317	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Thet_1319	COG1388	LysM domain
Thet_1319	COG1705	Flagellar rod assembly protein muramidase FlgJ
Thet_1321	COG0010	Belongs to the arginase family
Thet_1322	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Thet_1324	COG1187	pseudouridine synthase activity
Thet_1325	COG0445	tRNA wobble uridine modification
Thet_1327	COG1686	Belongs to the peptidase S11 family
Thet_1329	COG4864	UPF0365 protein
Thet_1330	COG1030	water channel activity
Thet_1331	COG1301	dicarboxylic acid transport
Thet_1332	COG3874	Sporulation protein YtfJ
Thet_1334	COG4086	secreted protein
Thet_1335	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Thet_1336	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Thet_1337	COG1994	Peptidase M50
Thet_1342	COG3360	Dodecin
Thet_1344	COG2172	sigma factor antagonist activity
Thet_1345	COG1366	Belongs to the anti-sigma-factor antagonist family
Thet_1346	COG1686	Belongs to the peptidase S11 family
Thet_1347	COG4974	Belongs to the 'phage' integrase family
Thet_1348	COG1300	Membrane
Thet_1349	COG1379	DNA repair
Thet_1358	COG0750	zinc metalloprotease
Thet_1359	COG0497	DNA recombination
Thet_1361	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Thet_1362	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Thet_1363	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Thet_1365	COG0142	geranyltranstransferase activity
Thet_1368	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Thet_1369	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Thet_1370	COG1302	Protein conserved in bacteria
Thet_1378	COG3854	ATPases associated with a variety of cellular activities
Thet_1380	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Thet_1381	COG0006	proline dipeptidase activity
Thet_1382	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Thet_1384	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Thet_1395	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Thet_1400	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Thet_1402	COG1191	sigma factor activity
Thet_1403	COG0768	penicillin binding
Thet_1406	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Thet_1407	COG4708	membrane
Thet_1408	COG3679	Belongs to the UPF0342 family
Thet_1409	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Thet_1410	COG0735	belongs to the Fur family
Thet_1411	COG3906	Belongs to the UPF0473 family
Thet_1413	COG4472	Bacterial protein of unknown function (DUF965)
Thet_1414	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Thet_1415	COG0628	permease
Thet_1417	COG0482	sulfurtransferase activity
Thet_1418	COG1959	2 iron, 2 sulfur cluster binding
Thet_1420	COG3457	Alanine racemase
Thet_1422	COG5012	cobalamin binding
Thet_1424	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Thet_1426	COG3804	dihydrodipicolinate reductase
Thet_1427	COG3118	belongs to the thioredoxin family
Thet_1428	COG1937	Protein conserved in bacteria
Thet_1429	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Thet_1433	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Thet_1435	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Thet_1437	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Thet_1437	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Thet_1439	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Thet_1439	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Thet_1440	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Thet_1448	COG2255	four-way junction helicase activity
Thet_1449	COG0632	four-way junction helicase activity
Thet_1450	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Thet_1452	COG0835	chemotaxis
Thet_1453	COG0217	transcriptional regulatory protein
Thet_1454	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Thet_1458	COG1739	Uncharacterized protein family UPF0029
Thet_1461	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Thet_1462	COG2385	sporulation resulting in formation of a cellular spore
Thet_1465	COG1982	Orn Lys Arg decarboxylase major
Thet_1466	COG3118	belongs to the thioredoxin family
Thet_1467	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Thet_1468	COG0785	Cytochrome C biogenesis protein
Thet_1472	COG2119	membrane
Thet_1473	COG3409	Peptidoglycan-binding domain 1 protein
Thet_1473	COG3773	Cell wall hydrolase
Thet_1475	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Thet_1476	COG0287	Prephenate dehydrogenase
Thet_1477	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Thet_1478	COG1605	Chorismate mutase
Thet_1478	COG0077	Prephenate dehydratase
Thet_1480	COG1164	Oligoendopeptidase f
Thet_1481	COG1760	l-serine dehydratase
Thet_1484	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Thet_1485	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Thet_1486	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Thet_1488	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Thet_1489	COG0426	domain, Protein
Thet_1491	COG3069	C4-dicarboxylate transmembrane transporter activity
Thet_1495	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Thet_1497	COG0584	glycerophosphoryl diester phosphodiesterase
Thet_1501	COG2267	carboxylic ester hydrolase activity
Thet_1510	COG1910	domain protein
Thet_1511	COG0303	'Molybdopterin
Thet_1512	COG0521	Mo-molybdopterin cofactor biosynthetic process
Thet_1518	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Thet_1521	COG2414	aldehyde ferredoxin oxidoreductase
Thet_1526	COG0693	protein deglycase activity
Thet_1529	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
Thet_1533	COG1132	(ABC) transporter
Thet_1539	COG1132	(ABC) transporter
Thet_1550	COG1132	(ABC) transporter
Thet_1553	COG0557	exoribonuclease II activity
Thet_1555	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Thet_1555	COG0574	Belongs to the PEP-utilizing enzyme family
Thet_1556	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Thet_1557	COG0517	IMP dehydrogenase activity
Thet_1558	COG0423	glycine-tRNA ligase activity
Thet_1562	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Thet_1563	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Thet_1564	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Thet_1565	COG1480	7TM receptor with intracellular HD hydrolase
Thet_1566	COG1702	phosphate starvation-inducible protein PhoH
Thet_1571	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Thet_1572	COG0537	adenosine 5'-monophosphoramidase activity
Thet_1573	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Thet_1574	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Thet_1580	COG3344	reverse transcriptase
Thet_1582	COG0701	Predicted permease
Thet_1585	COG0475	glutathione-regulated potassium exporter activity
Thet_1587	COG1482	cell wall glycoprotein biosynthetic process
Thet_1588	COG0813	purine-nucleoside phosphorylase activity
Thet_1589	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Thet_1590	COG2384	SAM-dependent methyltransferase
Thet_1592	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Thet_1593	COG0358	DNA primase activity
Thet_1594	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Thet_1595	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Thet_1599	COG0126	phosphoglycerate kinase activity
Thet_1601	COG2390	Transcriptional regulator
Thet_1603	COG1254	Belongs to the acylphosphatase family
Thet_1604	COG0561	phosphatase activity
Thet_1606	COG2720	vancomycin resistance protein
Thet_1607	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Thet_1608	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Thet_1609	COG1067	ATP-dependent peptidase activity
Thet_1617	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Thet_1619	COG0564	pseudouridine synthase activity
Thet_1622	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Thet_1624	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Thet_1633	COG2217	Heavy metal translocating P-type atpase
Thet_1640	COG4824	toxin secretion phage lysis holin
Thet_1657	COG4695	Portal protein
Thet_1658	COG4626	Terminase
Thet_1658	COG1802	Transcriptional regulator
Thet_1666	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Thet_1675	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Thet_1675	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Thet_1693	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Thet_1696	COG3546	catalase activity
Thet_1697	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Thet_1698	COG1410	methionine synthase
Thet_1698	COG0646	methionine synthase
Thet_1699	COG0646	methionine synthase
Thet_1699	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Thet_1701	COG0058	SHG alpha-glucan phosphorylase activity
Thet_1703	COG0778	Nitroreductase
Thet_1704	COG2195	Cleaves the N-terminal amino acid of tripeptides
Thet_1706	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Thet_1708	COG1174	glycine betaine transport
Thet_1709	COG0517	IMP dehydrogenase activity
Thet_1709	COG1125	glycine betaine transport
Thet_1710	COG0471	metal ion transport
Thet_1710	COG3273	potassium ion transport
Thet_1711	COG0534	Mate efflux family protein
Thet_1713	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Thet_1716	COG0205	6-phosphofructokinase activity
Thet_1719	COG4109	DRTGG domain
Thet_1720	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thet_1723	COG0366	Alpha amylase catalytic
Thet_1724	COG1426	Protein conserved in bacteria
Thet_1727	COG3833	ABC-type maltose transport systems, permease component
Thet_1728	COG1175	transmembrane transport
Thet_1729	COG2182	Extracellular solute-binding protein
Thet_1734	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Thet_1736	COG1752	Esterase of the alpha-beta hydrolase superfamily
Thet_1738	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Thet_1748	COG2608	mercury ion transmembrane transporter activity
Thet_1749	COG2217	Heavy metal translocating P-type atpase
Thet_1752	COG0037	tRNA processing
Thet_1753	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Thet_1755	COG2205	protein histidine kinase activity
Thet_1756	COG0745	RESPONSE REGULATOR receiver
Thet_1761	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Thet_1763	COG2608	mercury ion transmembrane transporter activity
Thet_1764	COG0586	Pfam SNARE associated Golgi protein
Thet_1766	COG5001	Diguanylate cyclase
Thet_1766	COG3447	MASE1 domain protein
Thet_1766	COG5002	protein histidine kinase activity
Thet_1770	COG2199	diguanylate cyclase activity
Thet_1770	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Thet_1772	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Thet_1772	COG1918	ferrous iron import across plasma membrane
Thet_1774	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Thet_1774	COG1918	ferrous iron import across plasma membrane
Thet_1778	COG1120	ATPase activity
Thet_1779	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Thet_1781	COG0446	pyridine nucleotide-disulphide oxidoreductase
Thet_1782	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Thet_1785	COG0489	protein tyrosine kinase activity
Thet_1786	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Thet_1789	COG2226	methyltransferase
Thet_1793	COG1609	Transcriptional regulator
Thet_1794	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Thet_1795	COG1621	beta-fructofuranosidase activity
Thet_1798	COG2182	Extracellular solute-binding protein
Thet_1801	COG0768	penicillin binding
Thet_1808	COG0733	neurotransmitter:sodium symporter activity
Thet_1810	COG4977	sequence-specific DNA binding
Thet_1810	COG1917	Cupin 2, conserved barrel domain protein
Thet_1812	COG0395	ABC-type sugar transport system, permease component
Thet_1813	COG1175	transmembrane transport
Thet_1814	COG1653	transport
Thet_1817	COG0383	alpha-mannosidase activity
Thet_1818	COG3250	beta-galactosidase activity
Thet_1824	COG1940	carbohydrate kinase activity
Thet_1825	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Thet_1826	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Thet_1827	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
Thet_1832	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Thet_1833	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Thet_1834	COG1349	DNA-binding transcription factor activity
Thet_1835	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Thet_1839	COG0673	inositol 2-dehydrogenase activity
Thet_1840	COG0673	inositol 2-dehydrogenase activity
Thet_1849	COG3885	ferrous iron binding
Thet_1849	COG2078	PFAM AMMECR1 domain protein
Thet_1852	COG0318	PFAM AMP-dependent synthetase and ligase
Thet_1853	COG1940	carbohydrate kinase activity
Thet_1855	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Thet_1859	COG0768	penicillin binding
Thet_1863	COG0556	nucleotide-excision repair
Thet_1864	COG2045	Belongs to the ComB family
Thet_1865	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Thet_1866	COG3409	Peptidoglycan-binding domain 1 protein
Thet_1866	COG0793	Belongs to the peptidase S41A family
Thet_1867	COG0739	heme binding
Thet_1868	COG2177	Part of the ABC transporter FtsEX involved in
Thet_1869	COG2884	Cell division ATP-binding protein ftsE
Thet_1870	COG3835	regulator
Thet_1871	COG3842	ATPase activity
Thet_1873	COG0019	diaminopimelate decarboxylase activity
Thet_1874	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Thet_1875	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Thet_1879	COG0849	cell division
Thet_1887	COG0443	Heat shock 70 kDa protein
Thet_1889	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Thet_1889	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thet_1889	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
Thet_1891	COG2376	Dihydroxyacetone kinase
Thet_1894	COG0446	pyridine nucleotide-disulphide oxidoreductase
Thet_1897	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Thet_1898	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
Thet_1903	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Thet_1905	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
Thet_1906	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Thet_1908	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Thet_1909	COG0140	phosphoribosyl-ATP diphosphatase activity
Thet_1909	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Thet_1912	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Thet_1915	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Thet_1916	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Thet_1922	COG0673	inositol 2-dehydrogenase activity
Thet_1923	COG1940	carbohydrate kinase activity
Thet_1925	COG1172	Belongs to the binding-protein-dependent transport system permease family
Thet_1927	COG0673	inositol 2-dehydrogenase activity
Thet_1929	COG1082	Xylose isomerase domain protein TIM barrel
Thet_1934	COG1131	(ABC) transporter
Thet_1935	COG3459	Glycosyltransferase 36 associated
Thet_1936	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
Thet_1936	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Thet_1937	COG0673	inositol 2-dehydrogenase activity
Thet_1938	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Thet_1940	COG0460	homoserine dehydrogenase
Thet_1942	COG1773	rubredoxin
Thet_1944	COG1757	Na H antiporter
Thet_1945	COG0205	6-phosphofructokinase activity
Thet_1947	COG3958	Transketolase
Thet_1948	COG3959	Transketolase, thiamine diphosphate binding domain
Thet_1949	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Thet_1951	COG2337	Toxic component of a toxin-antitoxin (TA) module
Thet_1953	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Thet_1955	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Thet_1955	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Thet_1956	COG0736	holo-[acyl-carrier-protein] synthase activity
Thet_1964	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
Thet_1965	COG1793	dna ligase
Thet_1966	COG0432	Pfam Uncharacterised protein family UPF0047
Thet_1967	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Thet_1969	COG0204	Acyl-transferase
Thet_1969	COG0318	PFAM AMP-dependent synthetase and ligase
Thet_1972	COG0280	phosphate acetyltransferase
Thet_1978	COG3426	butyrate kinase activity
Thet_1979	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Thet_1980	COG0280	phosphate acetyltransferase
Thet_1981	COG3426	butyrate kinase activity
Thet_1983	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
Thet_1987	COG1305	Transglutaminase-like
Thet_1989	COG0714	Associated with various cellular activities
Thet_1990	COG0546	phosphoglycolate phosphatase activity
Thet_1992	COG1388	LysM domain
Thet_1992	COG1705	Flagellar rod assembly protein muramidase FlgJ
Thet_1997	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Thet_1999	COG0651	ATP synthesis coupled electron transport
Thet_2000	COG0651	ATP synthesis coupled electron transport
Thet_2004	COG1320	monovalent cation:proton antiporter activity
Thet_2007	COG1115	amino acid carrier protein
Thet_2008	COG1966	Carbon starvation protein
Thet_2011	COG2033	superoxide reductase activity
Thet_2014	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Thet_2015	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Thet_2016	COG0101	tRNA pseudouridine synthase activity
Thet_2017	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Thet_2018	COG1122	ATPase activity
Thet_2019	COG1122	ATPase activity
Thet_2020	COG0203	ribosomal protein L17
Thet_2021	COG0202	RNA polymerase activity
Thet_2022	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Thet_2023	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Thet_2024	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Thet_2026	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Thet_2029	COG0563	adenylate kinase activity
Thet_2030	COG0201	protein transport
Thet_2031	COG0200	Binds to the 23S rRNA
Thet_2032	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Thet_2033	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Thet_2035	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Thet_2036	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Thet_2037	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Thet_2038	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Thet_2039	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Thet_2040	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Thet_2041	COG0255	Belongs to the universal ribosomal protein uL29 family
Thet_2043	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Thet_2044	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Thet_2045	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Thet_2046	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Thet_2047	COG0089	rRNA binding
Thet_2048	COG0088	Forms part of the polypeptide exit tunnel
Thet_2050	COG0051	transcription antitermination factor activity, RNA binding
Thet_2051	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Thet_2052	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Thet_2054	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Thet_2055	COG1358	cellular component organization or biogenesis
Thet_2061	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Thet_2062	COG0250	Participates in transcription elongation, termination and antitermination
Thet_2063	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Thet_2064	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Thet_2065	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Thet_2066	COG1595	DNA-templated transcription, initiation
Thet_2067	COG3688	RNA-binding protein containing a PIN domain
Thet_2068	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Thet_2070	COG0215	cysteine-tRNA ligase activity
Thet_2071	COG1045	serine acetyltransferase
Thet_2075	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Thet_2077	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Thet_2078	COG4956	integral membrane protein (PIN domain superfamily)
Thet_2080	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Thet_2081	COG0542	response to heat
Thet_2082	COG3869	Catalyzes the specific phosphorylation of arginine residues in
Thet_2083	COG3880	PFAM UvrB UvrC protein
Thet_2086	COG0281	malic enzyme
Thet_2087	COG3344	reverse transcriptase
Thet_2088	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Thet_2089	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Thet_2090	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thet_2091	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thet_2091	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thet_2091	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thet_2092	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thet_2092	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thet_2092	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thet_2093	COG3711	transcriptional antiterminator
Thet_2093	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thet_2094	COG0745	RESPONSE REGULATOR receiver
Thet_2094	COG3706	GGDEF domain
Thet_2098	COG4224	UPF0291 protein
Thet_2100	COG4946	Tricorn protease homolog
Thet_2100	COG1506	peptidase
Thet_2100	COG0823	Involved in the tonB-independent uptake of proteins
Thet_2101	COG1489	DNA binding
Thet_2102	COG0720	synthase
Thet_2103	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Thet_2104	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Thet_2105	COG0302	gtp cyclohydrolase
Thet_2107	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Thet_2108	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Thet_2108	COG5322	oxidoreductase activity
Thet_2113	COG0697	spore germination
Thet_2114	COG0531	amino acid
Thet_2115	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Thet_2116	COG4684	Psort location CytoplasmicMembrane, score
Thet_2117	COG0511	ligase activity, forming carbon-carbon bonds
Thet_2117	COG5016	pyruvate
Thet_2119	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Thet_2123	COG3852	Histidine kinase
Thet_2126	COG0037	tRNA processing
Thet_2127	COG2208	phosphoserine phosphatase activity
Thet_2128	COG0697	spore germination
Thet_2132	COG1131	(ABC) transporter
Thet_2137	COG1063	alcohol dehydrogenase
Thet_2144	COG2217	Heavy metal translocating P-type atpase
Thet_2147	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Thet_2148	COG2217	Heavy metal translocating P-type atpase
Thet_2152	COG2205	protein histidine kinase activity
Thet_2153	COG0745	RESPONSE REGULATOR receiver
Thet_2160	COG3387	PFAM Glycoside hydrolase 15-related
Thet_2162	COG0395	ABC-type sugar transport system, permease component
Thet_2164	COG1175	transmembrane transport
Thet_2165	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Thet_2166	COG1940	carbohydrate kinase activity
Thet_2169	COG3344	reverse transcriptase
Thet_2170	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Thet_2191	COG3409	Peptidoglycan-binding domain 1 protein
Thet_2191	COG3773	Cell wall hydrolase
Thet_2200	COG4962	Type ii secretion system protein e
Thet_2205	COG0739	heme binding
Thet_2222	COG1396	sequence-specific DNA binding
Thet_2227	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Thet_2228	COG0248	Ppx GppA phosphatase
Thet_2228	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Thet_2229	COG1098	S1 RNA binding domain
Thet_2236	COG2385	sporulation resulting in formation of a cellular spore
Thet_2237	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Thet_2238	COG0776	regulation of translation
Thet_2239	COG3956	TIGRFAM MazG family protein
Thet_2241	COG2814	Major facilitator Superfamily
Thet_2242	COG1160	GTP binding
Thet_2243	COG1027	Aspartate ammonia-lyase
Thet_2245	COG2033	superoxide reductase activity
Thet_2247	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Thet_2253	COG0142	geranyltranstransferase activity
Thet_2257	COG1528	Iron-storage protein
Thet_2260	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Thet_2261	COG0165	Argininosuccinate lyase
Thet_2264	COG0505	Belongs to the CarA family
Thet_2265	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Thet_2267	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Thet_2274	COG0493	'glutamate synthase
Thet_2274	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Thet_2275	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Thet_2275	COG1796	DNA polymerase
Thet_2277	COG1131	(ABC) transporter
Thet_2281	COG1595	DNA-templated transcription, initiation
Thet_2292	COG0671	phosphoesterase, PA-phosphatase related
Thet_2293	COG3859	Proton-coupled thiamine transporter YuaJ
Thet_2294	COG1132	(ABC) transporter
Thet_2296	COG1846	Transcriptional regulator
Thet_2299	COG1012	belongs to the aldehyde dehydrogenase family
Thet_2299	COG1454	alcohol dehydrogenase
Thet_2301	COG0667	Aldo Keto reductase
Thet_2303	COG4166	transmembrane transport
Thet_2304	COG0601	transmembrane transport
Thet_2305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Thet_2306	COG0444	Belongs to the ABC transporter superfamily
Thet_2307	COG4608	Belongs to the ABC transporter superfamily
Thet_2311	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Thet_2313	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Thet_2314	COG0018	arginyl-trna synthetase
Thet_2316	COG1181	Belongs to the D-alanine--D-alanine ligase family
Thet_2318	COG2959	enzyme of heme biosynthesis
Thet_2319	COG3773	Cell wall hydrolase
Thet_2319	COG3409	Peptidoglycan-binding domain 1 protein
Thet_2322	COG0531	amino acid
Thet_2323	COG0697	spore germination
Thet_2326	COG1802	Transcriptional regulator
Thet_2328	COG1388	LysM domain
Thet_2329	COG4466	Protein conserved in bacteria
Thet_2331	COG2002	toxin-antitoxin pair type II binding
Thet_2332	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Thet_2333	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Thet_2336	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Thet_2337	COG5002	protein histidine kinase activity
Thet_2338	COG0745	RESPONSE REGULATOR receiver
Thet_2339	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Thet_2340	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Thet_2342	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Thet_2343	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Thet_2346	COG0071	Belongs to the small heat shock protein (HSP20) family
Thet_2349	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thet_2349	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thet_2349	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thet_2351	COG1349	DNA-binding transcription factor activity
Thet_2353	COG0504	CTP synthase activity
Thet_2355	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Thet_2356	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Thet_2358	COG0083	homoserine kinase activity
Thet_2359	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Thet_2360	COG0460	homoserine dehydrogenase
Thet_2361	COG4492	Belongs to the UPF0735 family
Thet_2362	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Thet_2364	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Thet_2365	COG1518	maintenance of DNA repeat elements
Thet_2367	COG3340	Belongs to the peptidase S51 family
Thet_2376	COG0822	iron-sulfur transferase activity
Thet_2377	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Thet_2379	COG0719	Fe-S assembly protein
Thet_2380	COG0396	ATPase activity
Thet_2381	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Thet_2386	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Thet_2390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Thet_2391	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Thet_2393	COG0739	heme binding
Thet_2395	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Thet_2396	COG0308	aminopeptidase N
Thet_2399	COG2333	competence protein COMEC
Thet_2399	COG0658	competence protein
Thet_2402	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Thet_2403	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Thet_2404	COG0840	transmembrane signaling receptor activity
Thet_2406	COG0446	pyridine nucleotide-disulphide oxidoreductase
Thet_2410	COG1394	ATPase activity, coupled to movement of substances
Thet_2413	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
Thet_2414	COG1527	subunit (C
Thet_2416	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Thet_2417	COG1269	ATP hydrolysis coupled proton transport
Thet_2436	COG0305	Participates in initiation and elongation during chromosome replication
Thet_2437	COG0359	binds to the 23S rRNA
Thet_2438	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
Thet_2441	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Thet_2442	COG0629	single-stranded DNA binding
Thet_2443	COG0360	Binds together with S18 to 16S ribosomal RNA
Thet_2444	COG4481	Protein conserved in bacteria
Thet_2445	COG0668	transmembrane transport
Thet_2447	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Thet_2447	COG0189	ligase activity
Thet_2449	COG1597	lipid kinase activity
Thet_2451	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Thet_2452	COG1475	DNA binding
Thet_2453	COG1192	Involved in chromosome partitioning
Thet_2457	COG0445	tRNA wobble uridine modification
Thet_2459	COG1847	R3H domain protein
Thet_2460	COG0706	membrane insertase activity
Thet_2461	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Thet_2462	COG0594	ribonuclease P activity
Thet_2463	COG0230	Belongs to the bacterial ribosomal protein bL34 family