locus-tag class description Teth514_0001 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) Teth514_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) Teth514_0003 ENOG410848D S4 domain protein YaaA Teth514_0007 ENOG4105F1K Glutamine amidotransferase Teth514_0009 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Teth514_0010 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Teth514_0011 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Teth514_0014 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) Teth514_0016 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Teth514_0017 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) Teth514_0018 ENOG4105C01 Dihydroxy-acid dehydratase Teth514_0019 ENOG4105C7K acetolactate synthase Teth514_0020 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) Teth514_0021 ENOG4108R6K riboflavin synthase, subunit alpha Teth514_0024 ENOG4108REF Sporulation integral membrane protein ytvi Teth514_0028 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) Teth514_0031 ENOG4108Z6B deaminase Teth514_0032 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Teth514_0033 ENOG4105C6E dna polymerase iii Teth514_0036 ENOG4105WMR Protein CrcB homolog Teth514_0037 ENOG4105WMR Protein CrcB homolog Teth514_0038 ENOG4105DHT Metal Dependent Phosphohydrolase Teth514_0045 ENOG4105CUC YeeE YedE family protein Teth514_0047 ENOG41066VF YeeE YedE family protein Teth514_0049 ENOG4105DKQ ROK family Teth514_0050 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) Teth514_0052 ENOG4105CXN decarboxylase Teth514_0053 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) Teth514_0054 ENOG4105X0R protein from nitrogen regulatory protein P-II Teth514_0056 ENOG4107QRG dna polymerase iii Teth514_0057 ENOG4105MA4 psp1 domain protein Teth514_0058 ENOG4105CEU Arginine dihydrolase Teth514_0059 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) Teth514_0060 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) Teth514_0062 ENOG4105KRN Transcriptional regulator, abrb family Teth514_0063 ENOG4108JIC nucleoside recognition domain protein Teth514_0065 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate Teth514_0066 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) Teth514_0067 ENOG4105F8V Hydrolase, tatD family Teth514_0068 ENOG41069ER domain protein Teth514_0069 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) Teth514_0073 ENOG4105WJF Teth514_0074 ENOG4108WZW RNA polymerase sigma Teth514_0075 ENOG4105D1F ATP-binding protein Teth514_0078 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Teth514_0079 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) Teth514_0080 ENOG4105D6A Electron transport complex Teth514_0081 ENOG41080WF Electron transport complex, RnfABCDGE type, G subunit Teth514_0082 ENOG4105DZB Electron transport complex Teth514_0083 ENOG4105DGN Electron transport complex Teth514_0084 ENOG4107SVV electron transport complex, RnfABCDGE type, B subunit Teth514_0087 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Teth514_0089 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) Teth514_0090 ENOG41082DI 50s ribosomal protein l31 Teth514_0091 ENOG4107104 thymidine kinase Teth514_0092 ENOG4105CBJ Metal-dependent enzyme Teth514_0095 ENOG41081FK Mediates zinc uptake. May also transport other divalent cations (By similarity) Teth514_0096 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Teth514_0097 ENOG4107WAU Protein tyrosine phosphatase Teth514_0098 ENOG4108YZG isomerase Teth514_0099 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) Teth514_0103 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) Teth514_0104 ENOG4105DCF alanine dehydrogenase Teth514_0108 ENOG4105MT0 Sporulation transcriptional regulator spoiiid Teth514_0110 ENOG4108JQA flagellar Teth514_0111 ENOG4105CGA flagellar basal-body rod protein FlgG Teth514_0117 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase Teth514_0120 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Teth514_0123 ENOG4105DT3 PTS system, galactitol-specific IIc component Teth514_0127 ENOG4105CXK mandelate racemase muconate lactonizing Teth514_0128 ENOG4105C5I Dehydrogenase Teth514_0129 ENOG4108UHU Aldolase Teth514_0130 ENOG4108SC4 )-transporter Teth514_0131 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Teth514_0132 ENOG4105YHU PTS system Teth514_0134 ENOG4105F3R pts system mannose fructose sorbose family iid Teth514_0135 ENOG4108IQ3 PTS system Teth514_0137 ENOG4108UHU Aldolase Teth514_0138 ENOG4105C5I Dehydrogenase Teth514_0139 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) Teth514_0140 ENOG4105CZN Potassium uptake protein Teth514_0144 ENOG4108RCM Nitroreductase Teth514_0147 ENOG4108KB2 LysR family Transcriptional regulator Teth514_0154 ENOG4105CMG Carbohydrate kinase Teth514_0155 ENOG4105DFW ABC transporter Teth514_0156 ENOG4105EKQ RNA-directed DNA polymerase Teth514_0158 ENOG4108HWW ABC transporter Teth514_0161 ENOG4105ETE Transcriptional regulator (LacI family Teth514_0162 ENOG4108RVA ribokinase Teth514_0163 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) Teth514_0164 ENOG4105C2J ABC transporter Teth514_0165 ENOG4105CNN ABC, transporter Teth514_0166 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator Teth514_0167 ENOG4105EKQ RNA-directed DNA polymerase Teth514_0168 ENOG4106KNT transcriptional regulator Teth514_0169 ENOG4105C5Y PTS System Teth514_0173 ENOG4108M21 Teth514_0175 ENOG4105MUZ Protein of unknown function DUF2620 Teth514_0176 ENOG4106M0N transport system permease protein Teth514_0178 ENOG41080QX K07048 phosphotriesterase-related protein Teth514_0179 ENOG4106PKC pyridoxal phosphate binding Teth514_0180 ENOG4108626 Racemase Teth514_0181 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) Teth514_0182 ENOG4105D17 glycoside hydrolase, family 3 domain protein Teth514_0183 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) Teth514_0184 ENOG4105CE4 GlcNAc 6-P deacetylase Teth514_0185 ENOG4105CHM Aminotransferase Teth514_0186 ENOG4108ZB6 transcriptional regulator AsnC family Teth514_0188 ENOG4105CE1 Ferrous iron transport protein b Teth514_0189 ENOG4108JJB ABC transporter Teth514_0190 ENOG4108YZP cobalt ABC transporter, inner membrane subunit CbiQ Teth514_0191 ENOG4105G01 cobalamin (vitamin B12) biosynthesis CbiM protein Teth514_0192 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) Teth514_0193 ENOG4105MRR Transcriptional regulator (By similarity) Teth514_0195 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) Teth514_0198 ENOG410624X efflux transporter, rnd family, mfp subunit Teth514_0199 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Teth514_0200 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Teth514_0201 ENOG4105ERH Fumarylacetoacetate hydrolase Teth514_0202 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination Teth514_0205 ENOG4105EYH Exonuclease Teth514_0207 ENOG4105D3R alkyl hydroperoxide reductase Teth514_0211 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) Teth514_0212 ENOG4107QPH glycogen) synthase Teth514_0216 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) Teth514_0221 ENOG4107NFR Fructose-1,6-bisphosphatase Teth514_0221 ENOG4107NFR Fructose-1,6-bisphosphatase Teth514_0223 ENOG4105C2F Histidine kinase Teth514_0224 ENOG4108VB1 regulatoR Teth514_0225 ENOG4105DFW ABC transporter Teth514_0226 ENOG4105DFW ABC transporter Teth514_0227 ENOG4105C2J ABC transporter Teth514_0228 ENOG4108HWW ABC transporter Teth514_0229 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor Teth514_0230 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor Teth514_0233 ENOG4105DF9 Lipoate-protein, ligase Teth514_0234 ENOG4107QN2 dihydrolipoyl dehydrogenase Teth514_0236 ENOG4105CHM Aminotransferase Teth514_0237 ENOG4106ETB IIa component Teth514_0238 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC Teth514_0241 ENOG4107QW4 alcohol dehydrogenase Teth514_0251 ENOG4105CIZ coA-substrate-specific enzyme activase Teth514_0253 ENOG4108T5I Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) Teth514_0254 ENOG4105C4B ABC transporter, permease Teth514_0255 ENOG4105C8T Leucyl-tRNA synthetase Teth514_0256 ENOG4108UMN azlc family Teth514_0258 ENOG4105DD7 kinase (PfkB family Teth514_0259 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) Teth514_0260 ENOG41089WN small, acid-soluble spore protein tlp Teth514_0261 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Teth514_0265 ENOG4105VCP PTS System Teth514_0266 ENOG4105F8D glycoside hydrolase family 4 Teth514_0267 ENOG4105CS2 ec 3.2.1.21 Teth514_0268 ENOG4105CTS PTS system mannitol-specific Teth514_0269 ENOG4105EMD TRANSCRIPTIONal Teth514_0272 ENOG4105CGH 5'-nucleotidase Teth514_0273 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) Teth514_0274 ENOG4105EJ9 Membrane Teth514_0277 ENOG4105FDK ABC transporter Teth514_0278 ENOG4105DSE periplasmic solute binding protein Teth514_0279 ENOG4105N80 Ferric uptake regulator, Fur family Teth514_0280 ENOG4105C7R Atpase associated with various cellular activities aaa_3 Teth514_0283 ENOG4108V0P LemA family Teth514_0284 ENOG4105DUM transcriptional regulator, lysR family Teth514_0285 ENOG4105D5B Sulfite reductase, subunit A Teth514_0286 ENOG4107SHJ sulfite reductase subunit b Teth514_0287 ENOG410810Y Sulfite reductase Teth514_0290 ENOG4107YH3 SUF system FeS assembly protein, NifU family Teth514_0293 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) Teth514_0296 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) Teth514_0297 ENOG4105EHG Permease protein Teth514_0298 ENOG4105E0A ABC, transporter Teth514_0299 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) Teth514_0304 ENOG4105CIH Imidazole acetol-phosphate transaminase Teth514_0305 ENOG4108YZT Adenosylcobinamide kinase Teth514_0308 ENOG41081F0 Precorrin-8x methylmutase Teth514_0311 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase Teth514_0312 ENOG4105DVK Precorrin-2 c20-methyltransferase Teth514_0313 ENOG4105CIA precorrin-4 C(11)-methyltransferase Teth514_0314 ENOG4108P62 biosynthesis protein (CbiG) Teth514_0315 ENOG4105E4R Precorrin-3B C17-methyltransferase Teth514_0316 ENOG4108JTQ reductase Teth514_0317 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) Teth514_0320 ENOG4105D52 delta-aminolevulinic acid dehydratase Teth514_0321 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase Teth514_0323 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) Teth514_0326 ENOG4108JJB ABC transporter Teth514_0329 ENOG4108IUW ABC transporter Teth514_0338 ENOG4105FDK ABC transporter Teth514_0340 ENOG4108IUW ABC transporter Teth514_0341 ENOG4108SDH ABC, transporter Teth514_0348 ENOG4108ZXC Two component transcriptional regulator, luxr family Teth514_0350 ENOG4105CJ1 ABC, transporter Teth514_0361 ENOG4105FDK ABC transporter Teth514_0363 ENOG4108IUW ABC transporter Teth514_0364 ENOG4108SDH ABC, transporter Teth514_0372 ENOG4105DA5 (ABC) transporter Teth514_0376 ENOG4105CN9 Peptidase m42 family protein Teth514_0377 ENOG4105CN9 Peptidase m42 family protein Teth514_0378 ENOG4105CN9 Peptidase m42 family protein Teth514_0383 ENOG4105EKQ RNA-directed DNA polymerase Teth514_0385 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Teth514_0389 ENOG41080BE Methyl-accepting chemotaxis sensory transducer Teth514_0390 ENOG4105CCS Glutamate formiminotransferase Teth514_0391 ENOG4105CI2 imidazolone-5-propionate hydrolase Teth514_0394 ENOG4107V4V glycoside hydrolase family 4 Teth514_0397 ENOG4107T3P ABC, transporter Teth514_0398 ENOG4105C2F Histidine kinase Teth514_0399 ENOG4105EQD regulatoR Teth514_0400 ENOG410908R Methenyltetrahydrofolate cyclohydrolase Teth514_0401 ENOG4107TFB basic membrane Teth514_0402 ENOG4108JQ9 ABC transporter Teth514_0403 ENOG4105UIB (ABC) transporter Teth514_0408 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) Teth514_0410 ENOG4105C8Q Methyl-accepting chemotaxis Teth514_0412 ENOG4105CI1 PTS System Teth514_0413 ENOG4105C5Y PTS System Teth514_0415 ENOG4107SDT Homocitrate synthase Teth514_0424 ENOG4105CBX hi0933 family Teth514_0425 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) Teth514_0427 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) Teth514_0429 ENOG41066UU tRNA (Adenine-N1-)-methyltransferase Teth514_0430 ENOG4105VTR Integrase Teth514_0432 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit Teth514_0433 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) Teth514_0436 ENOG4105H67 Protein of unknown function (DUF421) Teth514_0437 ENOG410667J hydrolase Teth514_0438 ENOG4105ETE Transcriptional regulator (LacI family Teth514_0439 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Teth514_0440 ENOG4105BZU Histidine kinase Teth514_0444 ENOG4108RAC Rubrerythrin Teth514_0445 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP Teth514_0446 ENOG4105C7H Helicase, RecD TraA family Teth514_0447 ENOG4105MJ2 Competence protein Teth514_0451 ENOG4105E1Q flagellar hook-associated protein Teth514_0452 ENOG4105DTJ flagellar hook-associated protein Teth514_0454 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) Teth514_0455 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) Teth514_0461 ENOG4105CAQ asparagine synthetase Teth514_0464 ENOG4107RT6 flagellar hook-associated Teth514_0465 ENOG4105MQ3 flagellar protein FliS Teth514_0468 ENOG4108HW3 (ABC) transporter Teth514_0469 ENOG4105E5Q amino acid AbC transporter Teth514_0473 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Teth514_0475 ENOG4108Z3G 3H domain protein Teth514_0477 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving Teth514_0478 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) Teth514_0482 ENOG4105CD3 dihydroorotase Teth514_0483 ENOG4105CEU Arginine dihydrolase Teth514_0484 ENOG4105DBV ornithine carbamoyltransferase Teth514_0485 ENOG4105C5B carbamate kinase Teth514_0487 ENOG4105EKQ RNA-directed DNA polymerase Teth514_0488 ENOG4105K8N protein family UPF0079, ATPase Teth514_0489 ENOG41072GX Peptidase M22 Glycoprotease Teth514_0491 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Teth514_0493 ENOG4105C5H ABC transporter Teth514_0494 ENOG4105E14 MotA TolQ exbB proton channel Teth514_0495 ENOG4106VK6 Flagellar motor protein Teth514_0498 ENOG4105DY9 regulatoR Teth514_0499 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism Teth514_0502 ENOG4105CDJ oxidoreductase FAD NAD(P)-binding domain protein Teth514_0507 ENOG4108UQV Membrane Teth514_0509 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin Teth514_0512 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) Teth514_0513 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) Teth514_0514 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) Teth514_0515 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) Teth514_0516 ENOG4105C7N Xanthine uracil vitamin C permease Teth514_0517 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) Teth514_0518 ENOG4105C8V SAICAR synthetase Teth514_0519 ENOG4105VR9 phosphoribosylformylglycinamidine synthase Teth514_0520 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I Teth514_0524 ENOG4108V3E phosphoribosylglycinamide formyltransferase Teth514_0526 ENOG4107QNG Phosphoribosylglycinamide synthetase Teth514_0528 ENOG4105CH2 amidohydrolase Teth514_0529 ENOG4105CKP Polysaccharide Biosynthesis Protein Teth514_0531 ENOG4105ETD TRANSCRIPTIONal Teth514_0533 ENOG4105VZJ PTS System Teth514_0534 ENOG4105CK1 PTS System Teth514_0535 ENOG4105VCP PTS System Teth514_0536 ENOG4105KGF protein, YerC YecD Teth514_0537 ENOG4105C4R Atp-dependent dna helicase Teth514_0539 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) Teth514_0542 ENOG4108K9K Uncharacterised protein family (UPF0236) Teth514_0547 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Teth514_0548 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Teth514_0550 ENOG4108JQ7 (ABC) transporter Teth514_0551 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) Teth514_0556 ENOG4108YZA Nitrogen regulatory protein pii Teth514_0558 ENOG4105EYU Glutamine amido-transferase Teth514_0559 ENOG4105CBC glutamate synthase Teth514_0560 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein Teth514_0563 ENOG4107QW8 radical SAM domain protein Teth514_0566 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) Teth514_0571 ENOG4108UTW Plays a role in the regulation of phosphate uptake Teth514_0572 ENOG4108IV0 ABC, transporter Teth514_0575 ENOG4105E98 transcriptional regulator DeoR family Teth514_0576 ENOG4105DE4 1-phosphofructokinase Teth514_0577 ENOG4105DM4 PTS System Teth514_0578 ENOG4105DM4 PTS System Teth514_0580 ENOG4105VN1 Heat shock protein Teth514_0582 ENOG4105ETE Transcriptional regulator (LacI family Teth514_0583 ENOG4105DFU Cell wall formation (By similarity) Teth514_0584 ENOG4105DFT pur operon repressor Teth514_0586 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) Teth514_0587 ENOG4105C5T Phosphoribosyl pyrophosphate synthase Teth514_0588 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Teth514_0589 ENOG4105BZU Histidine kinase Teth514_0590 ENOG4105C0H protease Teth514_0593 ENOG4108JA2 transcriptioN-repair coupling factor Teth514_0594 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) Teth514_0595 ENOG4108M14 stage v sporulation protein t Teth514_0596 ENOG4105XFA sporulation peptidase YabG Teth514_0597 ENOG4105W42 Veg protein Teth514_0600 ENOG4105DRR Transcriptional regulator, GntR family Teth514_0604 ENOG4108Q8B Spore germination protein Teth514_0605 ENOG4108Q5U germination protein, ger(x)c family Teth514_0606 ENOG4108ZXQ stage ii sporulation protein r Teth514_0608 ENOG4105MSI germination protein ypeb Teth514_0609 ENOG4105XEW small acid-soluble spore protein Teth514_0610 ENOG4105CPF Cell wall formation (By similarity) Teth514_0612 ENOG4105C75 arginyL-tRNA synthetase Teth514_0613 ENOG4107WCI zn-dependent hydrolase of the beta-lactamase fold-like protein Teth514_0615 ENOG4105CRQ synthase (Component I) Teth514_0616 ENOG4105CM2 brancheD-chain amino acid aminotransferase Teth514_0619 ENOG4108JQ7 (ABC) transporter Teth514_0621 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Teth514_0622 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Teth514_0625 ENOG4105CPC Aldo Keto reductase Teth514_0627 ENOG4108EKI Dehydrogenase Teth514_0630 ENOG41067TZ transcriptional regulator, MarR family Teth514_0632 ENOG4105BZ1 (ABC) transporter Teth514_0633 ENOG4105N67 Proton-coupled thiamine transporter YuaJ Teth514_0634 ENOG4105YVM Phosphoesterase, PA-phosphatase related Teth514_0635 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic Teth514_0644 ENOG4105EMN RNA polymerase sigma factor Teth514_0647 ENOG41069JR Teth514_0648 ENOG4105DA5 (ABC) transporter Teth514_0650 ENOG4105DCG PHP domain protein Teth514_0651 ENOG4105BZ8 glutamate synthase Teth514_0652 ENOG4105CDJ oxidoreductase FAD NAD(P)-binding domain protein Teth514_0658 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) Teth514_0660 ENOG4105C8Y Acetylornithine aminotransferase Teth514_0661 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain Teth514_0664 ENOG4105CH7 arginosuccinase Teth514_0668 ENOG41090A1 ferritin Teth514_0672 ENOG4105EAH synthase Teth514_0680 ENOG4105MAX Superoxide reductase Teth514_0681 ENOG4105BZU Histidine kinase Teth514_0682 ENOG4108IJ0 Aspartate ammonia-lyase Teth514_0683 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) Teth514_0684 ENOG4107SFI Major Facilitator superfamily Teth514_0686 ENOG4108IY2 MazG family Teth514_0687 ENOG4105K70 DNA-binding protein Teth514_0688 ENOG41082I2 s4 domain protein Teth514_0689 ENOG4105JFG SpoIID LytB domain protein Teth514_0690 ENOG4105VYY sporulation protein yabp Teth514_0696 ENOG41060GV RNA binding s1 domain protein Teth514_0697 ENOG4105D49 3-dehydroquinate synthase Teth514_0702 ENOG4108IMY Transcriptional regulator Teth514_0717 ENOG4105DR5 peptidase Teth514_0732 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Teth514_0748 ENOG4107RUY (E1 component), alpha subunit Teth514_0749 ENOG4105EKQ RNA-directed DNA polymerase Teth514_0752 ENOG4105E2R ROK family Teth514_0753 ENOG4105CD3 dihydroorotase Teth514_0754 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component Teth514_0756 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component Teth514_0758 ENOG4107YGS glycoside hydrolase 15-related Teth514_0761 ENOG4105DQ6 Transposase Teth514_0762 ENOG4108K9K Uncharacterised protein family (UPF0236) Teth514_0763 ENOG4108K9K Uncharacterised protein family (UPF0236) Teth514_0766 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Teth514_0767 ENOG4105EB3 Histidine kinase Teth514_0770 ENOG4105C59 p-type ATPase Teth514_0771 ENOG4105C6T cysteine synthase Teth514_0774 ENOG4105C59 p-type ATPase Teth514_0775 ENOG4105BZU Histidine kinase Teth514_0780 ENOG4105CPQ Dehydrogenase Teth514_0784 ENOG4108T0W nitrous oxide maturation protein NosY Teth514_0788 ENOG4105SX7 Transporter Teth514_0791 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) Teth514_0792 ENOG4108UGV hypoxanthine phosphoribosyltransferase Teth514_0794 ENOG4105BZU Histidine kinase Teth514_0797 ENOG4107QX3 carboxylase Teth514_0799 ENOG4107QSA Oxaloacetate decarboxylase Teth514_0800 ENOG4105FH5 Membrane Teth514_0801 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) Teth514_0802 ENOG4105GEU Spore germination protein Teth514_0803 ENOG4105E1K spore germination protein Teth514_0809 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) Teth514_0811 ENOG4105EUJ GTP cyclohydrolase i Teth514_0812 ENOG4105EEI dihydropteroate synthase Teth514_0813 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Teth514_0814 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase Teth514_0815 ENOG4105PW4 Sugar fermentation stimulation protein homolog Teth514_0816 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein Teth514_0822 ENOG4105BZU Histidine kinase Teth514_0823 ENOG4105EMD TRANSCRIPTIONal Teth514_0824 ENOG4105DM4 PTS System Teth514_0825 ENOG4105DM4 PTS System Teth514_0826 ENOG4108YRF PTS System Teth514_0827 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) Teth514_0828 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) Teth514_0829 ENOG4105EKQ RNA-directed DNA polymerase Teth514_0830 ENOG4105C6K Malic enzyme Teth514_0833 ENOG4108Z0C Uvrb UvrC protein Teth514_0834 ENOG41066A3 ATP guanido phosphotransferase Teth514_0835 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Teth514_0836 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) Teth514_0838 ENOG4105CTP PilT protein domain protein Teth514_0839 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) Teth514_0841 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) Teth514_0845 ENOG4105D7W serine acetyltransferase Teth514_0846 ENOG4105C8N cysteinyl-tRNA synthetase Teth514_0848 ENOG4105C2N RNA methyltransferase TrmH family group 3 Teth514_0849 ENOG4105M0M Tetracycline resistance protein Teth514_0851 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) Teth514_0853 ENOG410683Z Preprotein translocase SecE subunit Teth514_0854 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) Teth514_0855 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) Teth514_0861 ENOG4105XPM ribosomal protein Teth514_0862 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) Teth514_0864 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) Teth514_0865 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) Teth514_0866 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) Teth514_0868 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) Teth514_0869 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) Teth514_0870 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity Teth514_0871 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) Teth514_0872 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) Teth514_0873 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) Teth514_0875 ENOG41082SA 50s ribosomal protein l29 Teth514_0876 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal Teth514_0877 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) Teth514_0878 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) Teth514_0879 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits Teth514_0880 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) Teth514_0881 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) Teth514_0883 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) Teth514_0884 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) Teth514_0885 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) Teth514_0886 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) Teth514_0887 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) Teth514_0890 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) Teth514_0892 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits Teth514_0893 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) Teth514_0894 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) Teth514_0895 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Teth514_0896 ENOG4108ZT0 50S ribosomal protein l17 Teth514_0897 ENOG4108JJB ABC transporter Teth514_0898 ENOG4108JJB ABC transporter Teth514_0899 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) Teth514_0900 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) Teth514_0901 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) Teth514_0902 ENOG4108UJD 30S ribosomal protein S9 Teth514_0907 ENOG4108YZ8 Superoxide reductase Teth514_0909 ENOG4105D22 carbon starvation protein Teth514_0910 ENOG4105BZG amino acid carrier protein Teth514_0911 ENOG4105SC1 monovalent cation H antiporter subunit E Teth514_0913 ENOG4105KJM monovalent cation h antiporter subunit g Teth514_0917 ENOG4108JPZ Monovalent cation H antiporter subunit D Teth514_0918 ENOG4108JPZ Monovalent cation H antiporter subunit D Teth514_0920 ENOG4107SMJ Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) Teth514_0927 ENOG4107XGZ Hydrolase Teth514_0928 ENOG4105C7R Atpase associated with various cellular activities aaa_3 Teth514_0934 ENOG4105C8B TIGR00159 family Teth514_0936 ENOG4105CKM Branched-chain carboxylic acid kinase Teth514_0937 ENOG4107RE7 phosphate butyryltransferase Teth514_0938 ENOG4107RDP Dehydrogenase Teth514_0939 ENOG4105CKM Branched-chain carboxylic acid kinase Teth514_0945 ENOG4107RE7 phosphate butyryltransferase Teth514_0948 ENOG4105CEY Amp-dependent synthetase and ligase Teth514_0950 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) Teth514_0951 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme Teth514_0952 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) Teth514_0953 ENOG4105FDF Could be involved in DNA repair (By similarity) Teth514_0961 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) Teth514_0962 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) Teth514_0964 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) Teth514_0966 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) Teth514_0967 ENOG4108JYZ YitT family Teth514_0968 ENOG4108HHA Transketolase Teth514_0969 ENOG4108IUS Transketolase Teth514_0971 ENOG4105CTQ phosphohexokinase Teth514_0972 ENOG4105DFD Na H antiporter Teth514_0973 ENOG4105VCQ rubredoxin Teth514_0975 ENOG4105D6E homoserine dehydrogenase Teth514_0977 ENOG4105DWV Homoserine O-trans-acetylase Teth514_0978 ENOG4105CK5 oxidoreductase Teth514_0979 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B Teth514_0980 ENOG4105E2V Glycosyltransferase 36 Teth514_0981 ENOG4105CJ1 ABC, transporter Teth514_0986 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) Teth514_0990 ENOG4105CNN ABC, transporter Teth514_0992 ENOG4105DKQ ROK family Teth514_0993 ENOG4105CK5 oxidoreductase Teth514_1000 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) Teth514_1001 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) Teth514_1004 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) Teth514_1007 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase Teth514_1008 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) Teth514_1009 ENOG4108IGT Dipeptidase Teth514_1018 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator Teth514_1019 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) Teth514_1025 ENOG4105CMT Dihydroxyacetone kinase Teth514_1027 ENOG4105VDH Dihydroxyacetone kinase Teth514_1029 ENOG4105CFG Acts as a chaperone (By similarity) Teth514_1036 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) Teth514_1040 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 Teth514_1041 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) Teth514_1042 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) Teth514_1045 ENOG4107VHA regulatoR Teth514_1046 ENOG4105CAK Cell division ATP-binding protein ftsE Teth514_1047 ENOG4105CRP Part of the ABC transporter FtsEX involved in Teth514_1048 ENOG4105DR5 peptidase Teth514_1051 ENOG4108N5B 2-phosphosulfolactate phosphatase Teth514_1052 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) Teth514_1053 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) Teth514_1056 ENOG4105CJN penicillin-binding protein Teth514_1059 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) Teth514_1062 ENOG4105CEY Amp-dependent synthetase and ligase Teth514_1065 ENOG4105NBF ammecr1 domain protein Teth514_1074 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) Teth514_1078 ENOG4105C5I Dehydrogenase Teth514_1080 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) Teth514_1081 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) Teth514_1084 ENOG4105CMG Carbohydrate kinase Teth514_1086 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase Teth514_1087 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) Teth514_1088 ENOG4105CMR udp-glucose 4-epimerase Teth514_1089 ENOG4105E2R ROK family Teth514_1092 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component Teth514_1093 ENOG4105I1K ABC transporter Teth514_1095 ENOG4105CNT hydrolase family 2 Teth514_1096 ENOG4105C8I hydrolase, family 38 Teth514_1099 ENOG4107T3P ABC, transporter Teth514_1100 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component Teth514_1101 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component Teth514_1103 ENOG4105ID8 Transcriptional regulator, ARAC family Teth514_1104 ENOG4107SCA Formamidase (EC 3.5.1.49) Teth514_1105 ENOG4105C8J )-transporter Teth514_1112 ENOG4105CJN penicillin-binding protein Teth514_1115 ENOG4107FKK extracellular solute-binding protein family 1 Teth514_1118 ENOG4107R3K hydrolase Teth514_1119 ENOG4105D7K pfkb domain protein Teth514_1120 ENOG4105ETE Transcriptional regulator (LacI family Teth514_1121 ENOG4108JVH Protein of unknown function DUF43 Teth514_1124 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Teth514_1127 ENOG4105DSM The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity) Teth514_1128 ENOG4105D1F ATP-binding protein Teth514_1130 ENOG4107QW8 radical SAM domain protein Teth514_1131 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase Teth514_1133 ENOG4105EHG Permease protein Teth514_1134 ENOG4108HWH (ABC) transporter Teth514_1138 ENOG4105CE1 Ferrous iron transport protein b Teth514_1140 ENOG4105CE1 Ferrous iron transport protein b Teth514_1141 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Teth514_1142 ENOG4105G5W regulator Fur family Teth514_1146 ENOG4105BZU Histidine kinase Teth514_1148 ENOG4105DQR SNARE associated Golgi Teth514_1149 ENOG410681U heavy metal transport detoxification protein Teth514_1150 ENOG4105C6T cysteine synthase Teth514_1155 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Teth514_1156 ENOG4105EB3 Histidine kinase Teth514_1158 ENOG4105CUZ uba thif-type nad fad binding protein Teth514_1159 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) Teth514_1162 ENOG4105C59 p-type ATPase Teth514_1163 ENOG41082MP copper ion binding protein Teth514_1166 ENOG4105C59 p-type ATPase Teth514_1167 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Teth514_1169 ENOG41060I7 thioesterase Superfamily protein Teth514_1174 ENOG4105D78 K07001 NTE family protein Teth514_1176 ENOG4105D4A Cell wall formation (By similarity) Teth514_1181 ENOG4107FKK extracellular solute-binding protein family 1 Teth514_1182 ENOG4105D56 permease protein Teth514_1183 ENOG4105EG2 ABC transporter, permease Teth514_1187 ENOG4108IUK alpha amylase, catalytic Teth514_1190 ENOG4105KRI phosphocarrier protein (HPr Teth514_1192 ENOG4105C0B DNA polymerase III (alpha subunit) Teth514_1194 ENOG4105CTQ phosphohexokinase Teth514_1197 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) Teth514_1199 ENOG4105UQX Mate efflux family protein Teth514_1201 ENOG4108IJ8 ABC transporter Teth514_1202 ENOG4105E90 ABC transporter Teth514_1204 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) Teth514_1206 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) Teth514_1207 ENOG4108RCM Nitroreductase Teth514_1209 ENOG4107R76 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) Teth514_1211 ENOG4105C3R Methionine synthase Teth514_1212 ENOG4108UIN ybak prolyl-trna synthetase associated region Teth514_1213 ENOG4105WEF catalase Teth514_1216 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) Teth514_1221 ENOG4107XZC Restriction modification system DNA (Specificity Teth514_1234 ENOG4105C2M dna polymerase I Teth514_1243 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP Teth514_1245 ENOG4105EKQ RNA-directed DNA polymerase Teth514_1251 ENOG4105CAR Terminase, large subunit Teth514_1252 ENOG4105EFC phage portal protein HK97 family Teth514_1276 ENOG4105C59 p-type ATPase Teth514_1277 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) Teth514_1284 ENOG4105D1H recombination factor protein RarA Teth514_1285 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase Teth514_1288 ENOG4105EMS pseudouridine synthase Teth514_1290 ENOG4105C22 threonyL-tRNA synthetase Teth514_1292 ENOG4105C8Q Methyl-accepting chemotaxis Teth514_1295 ENOG410688J Ferredoxin Teth514_1297 ENOG4105DAN ATP-dependent protease Teth514_1298 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) Teth514_1299 ENOG4105CSM endonuclease III Teth514_1300 ENOG41073R8 VanW family Teth514_1301 ENOG4105G5W regulator Fur family Teth514_1302 ENOG410667J hydrolase Teth514_1303 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 Teth514_1307 ENOG4105BZA Phosphoglycerate kinase Teth514_1309 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) Teth514_1311 ENOG4105XZU Preprotein translocase, subunit SecG Teth514_1312 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein Teth514_1313 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) Teth514_1314 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Teth514_1317 ENOG4105EGD dinuclear metal center protein, YbgI family Teth514_1318 ENOG4105D3A purine nucleoside phosphorylase DeoD-type Teth514_1319 ENOG4105DG6 mannose-6-phosphate isomerase Teth514_1320 ENOG4107RWR Sodium hydrogen exchanger Teth514_1323 ENOG4107S21 permease Teth514_1325 ENOG4105EKQ RNA-directed DNA polymerase Teth514_1330 ENOG4105CKK Glycosyl transferase, family 2 Teth514_1332 ENOG4105EDW glycosyl transferase, family 39 Teth514_1333 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) Teth514_1334 ENOG4107YU2 histidine triad (hIT) protein Teth514_1335 ENOG4105VCC 30S ribosomal protein S21 Teth514_1337 ENOG4105HDK L-asparaginase Teth514_1338 ENOG41068P3 sporulation protein YqfC Teth514_1340 ENOG4105C9A Phoh family Teth514_1341 ENOG4105CTJ Metal Dependent Phosphohydrolase Teth514_1342 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) Teth514_1344 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) Teth514_1348 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) Teth514_1350 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) Teth514_1351 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) Teth514_1353 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) Teth514_1355 ENOG4105BZ1 (ABC) transporter Teth514_1365 ENOG4105BZ1 (ABC) transporter Teth514_1370 ENOG4105BZ1 (ABC) transporter Teth514_1374 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) Teth514_1377 ENOG4108Z0Z intracellular protease Pfpi family Teth514_1379 ENOG4107RUY (E1 component), alpha subunit Teth514_1380 ENOG4105WE2 aldehyde ferredoxin oxidoreductase Teth514_1383 ENOG4105D06 uba thif-type nad fad binding protein Teth514_1389 ENOG4108RIR Molybdenum cofactor biosynthesis protein Teth514_1390 ENOG4105CVM Molybdenum cofactor synthesis domain protein Teth514_1391 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family Teth514_1397 ENOG4105C2J ABC transporter Teth514_1401 ENOG4107S9D Alpha beta hydrolase Teth514_1405 ENOG4108QXE glycerophosphoryl diester phosphodiesterase Teth514_1407 ENOG4108UVJ appr-1-p processing domain protein Teth514_1410 ENOG41066FP Small acid-soluble spore protein I Teth514_1413 ENOG4105CNW domain protein Teth514_1414 ENOG4108UXE Protein tyrosine phosphatase Teth514_1417 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase Teth514_1418 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) Teth514_1421 ENOG4105EJQ L-serine dehydratase Teth514_1422 ENOG4105DPN Oligoendopeptidase f Teth514_1424 ENOG4105CQC Prephenate dehydratase Teth514_1425 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase Teth514_1426 ENOG4105EVN Prephenate dehydrogenase Teth514_1427 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase Teth514_1434 ENOG4107QIV Cytochrome c biogenesis protein Teth514_1435 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Teth514_1436 ENOG4105K63 Thioredoxin Teth514_1437 ENOG4105CXN decarboxylase Teth514_1440 ENOG4105JFG SpoIID LytB domain protein Teth514_1441 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) Teth514_1444 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein Teth514_1448 ENOG4105C6T cysteine synthase Teth514_1449 ENOG4105CDY transcriptional regulatory protein Teth514_1450 ENOG4108V3W Chemotaxis protein, CheW Teth514_1452 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) Teth514_1453 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) Teth514_1454 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) Teth514_1455 ENOG41061AI Protein of unknown function (DUF2905) Teth514_1461 ENOG4108Z0R Transferase Teth514_1462 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Teth514_1463 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Teth514_1465 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) Teth514_1470 ENOG4107VMB Beta-lactamase domain protein Teth514_1474 ENOG4105CUZ uba thif-type nad fad binding protein Teth514_1475 ENOG4105VPX protein, conserved in bacteria Teth514_1476 ENOG4105K63 Thioredoxin Teth514_1477 ENOG4108KR4 dihydrodipicolinate reductase Teth514_1479 ENOG4107RH1 pyridoxal-5'-phosphate-dependent protein beta subunit Teth514_1480 ENOG4105KIJ D-ornithine aminomutase S component Teth514_1481 ENOG4105EQ5 D-Lysine 5,6-aminomutase alpha subunit Teth514_1483 ENOG4106M28 alanine racemase domain protein Teth514_1486 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) Teth514_1488 ENOG4105C02 permease Teth514_1489 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) Teth514_1490 ENOG4105VBH UPF0297 protein Teth514_1492 ENOG41085AS UPF0473 protein Teth514_1493 ENOG4105I3K Ferric uptake regulator, Fur family Teth514_1494 ENOG4105CN5 Metallo-Beta-Lactamase Teth514_1495 ENOG41084CE UPF0342 protein Teth514_1496 ENOG410807C QueT transporter Teth514_1497 ENOG4105HHA aminodeoxychorismate lyase Teth514_1498 ENOG4108VQJ O-methyltransferase Teth514_1499 ENOG4105CFP Peptidase U32 Teth514_1500 ENOG4105CJN penicillin-binding protein Teth514_1501 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Teth514_1502 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) Teth514_1503 ENOG4105E2X shikimate dehydrogenase Teth514_1504 ENOG4107QHF type ii secretion system protein e Teth514_1505 ENOG4105CZX twitching motility protein Teth514_1519 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) Teth514_1521 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) Teth514_1522 ENOG4105DC7 peptidase M24 Teth514_1523 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) Teth514_1525 ENOG4105CD2 stage iii sporulation protein aa Teth514_1527 ENOG4108CQH stage III sporulation protein AC Teth514_1528 ENOG4105KQ4 Stage iii sporulation protein ad Teth514_1530 ENOG410644B Stage III sporulation protein af Teth514_1533 ENOG4108ZSR alkaline shock protein Teth514_1534 ENOG4105M7K Involved in the transcription termination process (By similarity) Teth514_1535 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) Teth514_1538 ENOG4105CTB Polyprenyl synthetase Teth514_1540 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) Teth514_1541 ENOG4105DX0 Hemolysin A Teth514_1542 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) Teth514_1544 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) Teth514_1545 ENOG4105S1Z Stage IV sporulation protein B Teth514_1546 ENOG4107QQR Sporulation Teth514_1554 ENOG4105MZ9 stage II sporulation protein m Teth514_1555 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Teth514_1556 ENOG4105DZ1 carboxypeptidase Teth514_1558 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) Teth514_1559 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Teth514_1560 ENOG41084UG Pfam:DUF1458 Teth514_1561 ENOG41090VF Stage v sporulation protein ac Teth514_1565 ENOG4108Z4T Peptidase M50 Teth514_1566 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) Teth514_1567 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) Teth514_1568 ENOG4105PTM secreted protein Teth514_1570 ENOG4105KBJ sporulation protein ytfj Teth514_1572 ENOG4105F7J membrane-bound serine protease Teth514_1573 ENOG4105DI5 UPF0365 protein Teth514_1575 ENOG4105DZ1 carboxypeptidase Teth514_1577 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) Teth514_1578 ENOG4105FE9 pseudouridine synthase Teth514_1580 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) Teth514_1581 ENOG4105CYW agmatinase Teth514_1582 ENOG4107QSA Oxaloacetate decarboxylase Teth514_1585 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) Teth514_1587 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein Teth514_1588 ENOG4105DQU oxidoreductase, subunit beta Teth514_1590 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) Teth514_1591 ENOG4105D82 Glutamate dehydrogenase Teth514_1592 ENOG4108J9M Transporter Teth514_1593 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) Teth514_1594 ENOG4105E7W lamb ycsf family protein Teth514_1595 ENOG4105P4J Allophanate hydrolase, subunit 1 Teth514_1597 ENOG4105CFM UPF0317 protein Teth514_1598 ENOG4105D82 Glutamate dehydrogenase Teth514_1600 ENOG4105CVJ phosphoglycerate mutase Teth514_1601 ENOG4105CBX hi0933 family Teth514_1604 ENOG4105CAT Cytidine monophosphate kinase Teth514_1606 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) Teth514_1608 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) Teth514_1609 ENOG4105BZU Histidine kinase Teth514_1611 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) Teth514_1613 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) Teth514_1614 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) Teth514_1615 ENOG4105II7 pyrroline-5-carboxylate reductase Teth514_1616 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Teth514_1617 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Teth514_1618 ENOG4105CXI aluminum resistance protein Teth514_1619 ENOG4106F1P AAA ATPase, central domain protein Teth514_1620 ENOG4105C83 adenylosuccinate lyase Teth514_1622 ENOG4105DB7 PHP domain protein Teth514_1623 ENOG4105MCT stage V sporulation protein S Teth514_1624 ENOG4105D48 metallophosphoesterase Teth514_1626 ENOG410902V Modulates RecA activity (By similarity) Teth514_1627 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) Teth514_1629 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase Teth514_1631 ENOG4105CNU cell division protein FtsK Teth514_1633 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit Teth514_1636 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) Teth514_1637 ENOG4105C1V Peptidase, M16 Teth514_1640 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) Teth514_1641 ENOG4105DTN riboflavin biosynthesis protein ribF Teth514_1642 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) Teth514_1644 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) Teth514_1647 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination Teth514_1648 ENOG4105CHV Transcription elongation factor NusA Teth514_1650 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) Teth514_1652 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) Teth514_1653 ENOG4105DZP Membrane-associated zinc metalloprotease Teth514_1655 ENOG4105KNE Phosphatidate cytidylyltransferase Teth514_1656 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) Teth514_1658 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) Teth514_1659 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) Teth514_1660 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) Teth514_1664 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Teth514_1665 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) Teth514_1667 ENOG4108V3W Chemotaxis protein, CheW Teth514_1668 ENOG4105CBS Chea signal transduction histidine kinase Teth514_1669 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) Teth514_1672 ENOG4105FZW flagellar biosynthesis regulator FlhF Teth514_1673 ENOG4105D7B Flagellar biosynthesis protein flha Teth514_1674 ENOG4105D00 flagellar biosynthetic protein flhB Teth514_1675 ENOG4105D19 Role in flagellar biosynthesis (By similarity) Teth514_1676 ENOG4105VS8 Flagellar biosynthetic protein fliq Teth514_1677 ENOG4105CN7 Flagellar biosynthetic protein FliP Teth514_1679 ENOG4107YTP response regulator receiver protein Teth514_1680 ENOG4105DD5 Flagellar motor switch protein Teth514_1681 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) Teth514_1683 ENOG41068WV flagellar FlbD family protein Teth514_1684 ENOG4105BZE flagellar hook protein, FlgE Teth514_1686 ENOG410822I Flagellar hook capping protein Teth514_1692 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) Teth514_1693 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) Teth514_1694 ENOG4105VQ0 flagellar hook-basal body complex protein fliE Teth514_1695 ENOG4108ZC9 flagellar basal-body rod protein flgc Teth514_1696 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) Teth514_1700 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) Teth514_1702 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Teth514_1703 ENOG4105VFF UPF0102 protein Teth514_1704 ENOG4105C31 Tryptophanyl-tRNA synthetase Teth514_1705 ENOG4108JYZ YitT family Teth514_1706 ENOG4105C0P Mg chelatase subunit ChlI Teth514_1708 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) Teth514_1709 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) Teth514_1710 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) Teth514_1711 ENOG4105VB6 UPF0109 protein Teth514_1714 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) Teth514_1715 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) Teth514_1718 ENOG4105MCT stage V sporulation protein S Teth514_1720 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) Teth514_1721 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) Teth514_1722 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) Teth514_1723 ENOG4105CHR reductase Teth514_1724 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase Teth514_1725 ENOG4105EA8 2-Nitropropane dioxygenase Teth514_1726 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) Teth514_1728 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) Teth514_1729 ENOG41067VY 50S ribosomal protein L32 Teth514_1730 ENOG4105KNH Nucleic acid-binding protein Teth514_1731 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) Teth514_1732 ENOG4108IJ2 phosphate acetyltransferase Teth514_1734 ENOG4105H20 Sporulation integral membrane protein YlbJ Teth514_1736 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) Teth514_1737 ENOG4106H78 methyltransferase Teth514_1740 ENOG4105EPR degv family Teth514_1741 ENOG4105CB5 ATP-dependent DNA helicase recG Teth514_1742 ENOG4105DP4 dak2 domain fusion protein ylov Teth514_1743 ENOG4108ZAA Alkaline-shock protein Teth514_1747 ENOG4105DJV ribulose-phosphate 3-epimerase Teth514_1748 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) Teth514_1749 ENOG4105D9P serine threonine protein kinase Teth514_1750 ENOG4108ZF3 Phosphatase Teth514_1751 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs Teth514_1752 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B Teth514_1755 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) Teth514_1758 ENOG4105C25 Primosomal protein n' Teth514_1759 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase Teth514_1761 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) Teth514_1763 ENOG4105DSJ YicC domain protein Teth514_1764 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) Teth514_1765 ENOG4105C6X Major Facilitator Teth514_1767 ENOG4105F23 Fibronectin-binding protein Teth514_1769 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) Teth514_1770 ENOG4108UMI ABC transporter, permease Teth514_1771 ENOG4105D01 (LipO)protein Teth514_1777 ENOG4108UN4 phage SPO1 DNA polymerase-related protein Teth514_1779 ENOG4106DSS Tartrate dehydratase subunit alpha Teth514_1780 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) Teth514_1781 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) Teth514_1783 ENOG4107EXU Short-chain dehydrogenase reductase Sdr Teth514_1784 ENOG4105CPF Cell wall formation (By similarity) Teth514_1788 ENOG4105CKB glycosidase Teth514_1789 ENOG4105CKB glycosidase Teth514_1792 ENOG4108JQ7 (ABC) transporter Teth514_1793 ENOG4105C3U ABC transporter Teth514_1796 ENOG4108J59 Extracellular solute-binding protein, family 5 Teth514_1805 ENOG4108WZW RNA polymerase sigma Teth514_1806 ENOG4105WJF Teth514_1808 ENOG4105CHR reductase Teth514_1810 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) Teth514_1813 ENOG4107XPQ Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) Teth514_1815 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) Teth514_1817 ENOG4105CD3 dihydroorotase Teth514_1818 ENOG4105CXT aspartate transcarbamylase Teth514_1819 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) Teth514_1820 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii Teth514_1821 ENOG4105C34 Pseudouridine synthase Teth514_1822 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) Teth514_1823 ENOG4105KNA -acetyltransferase Teth514_1828 ENOG4107QMH DNA methylase Teth514_1830 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) Teth514_1843 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) Teth514_1846 ENOG4108TVJ Nitroreductase Teth514_1847 ENOG4108AEY RNA polymerase sigma factor Teth514_1850 ENOG4105D9Q decarboxylase (Beta subunit) Teth514_1852 ENOG4108ZVT methylmalonyl-coA epimerase Teth514_1853 ENOG4105DJT lAO AO transport system ATPase Teth514_1860 ENOG4105C28 cystathionine Teth514_1861 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Teth514_1862 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase Teth514_1867 ENOG4108I0Q anthranilate phosphoribosyltransferase Teth514_1868 ENOG4105DDQ anthranilate synthase Teth514_1869 ENOG4105CRQ synthase (Component I) Teth514_1872 ENOG4105C28 cystathionine Teth514_1876 ENOG4105C28 cystathionine Teth514_1878 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) Teth514_1879 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) Teth514_1880 ENOG4108JJB ABC transporter Teth514_1881 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) Teth514_1883 ENOG4105FDP GntR family transcriptional regulator Teth514_1884 ENOG4105CR5 Class II aldolase adducin family protein Teth514_1885 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) Teth514_1886 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) Teth514_1889 ENOG4105DBK s4 domain protein Teth514_1891 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) Teth514_1892 ENOG4105DFA alanine racemase domain protein Teth514_1894 ENOG4105KME endoribonuclease L-psp Teth514_1895 ENOG4105C6Z Gluconate Teth514_1896 ENOG4105BZW Glycerate kinase Teth514_1897 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR Teth514_1903 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) Teth514_1907 ENOG4108UTZ Dihydroxyacetone kinase Teth514_1909 ENOG4105CMT Dihydroxyacetone kinase Teth514_1914 ENOG4105C26 Dehydrogenase Teth514_1917 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Teth514_1918 ENOG4105D2N Aldolase Teth514_1919 ENOG4105DB7 PHP domain protein Teth514_1921 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) Teth514_1922 ENOG4108YZG isomerase Teth514_1923 ENOG4108IUS Transketolase Teth514_1924 ENOG4108HHA Transketolase Teth514_1925 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) Teth514_1932 ENOG4105E0A ABC, transporter Teth514_1933 ENOG4105EHG Permease protein Teth514_1934 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) Teth514_1935 ENOG4105C0A alcohol dehydrogenase Teth514_1936 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) Teth514_1937 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) Teth514_1938 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place Teth514_1939 ENOG4108X49 Ethanolamine utilization protein EutK Teth514_1940 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) Teth514_1942 ENOG4108EKI Dehydrogenase Teth514_1944 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml Teth514_1946 ENOG4107RWI ethanolamine utilization protein eutJ Teth514_1947 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) Teth514_1948 ENOG4105KNY Microcompartments protein Teth514_1950 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit Teth514_1951 ENOG4108ZFT Dehydratase small subunit Teth514_1952 ENOG4105YCI dehydratase medium subunit Teth514_1954 ENOG4105EHR propanediol utilization protein pduB Teth514_1955 ENOG4105KNY Microcompartments protein Teth514_1958 ENOG4105WH1 Two component transcriptional regulator luxr family Teth514_1959 ENOG4105C2F Histidine kinase Teth514_1965 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin Teth514_1966 ENOG4108JUB Transcriptional regulator Teth514_1970 ENOG4105C0R drug resistance transporter emrb qaca subfamily Teth514_1971 ENOG4105CJ1 ABC, transporter Teth514_1973 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving Teth514_1974 ENOG4105C0X amino acid Teth514_1976 ENOG4105E9Q Acyl-transferase Teth514_1977 ENOG4108VYJ response regulator receiver protein Teth514_1980 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) Teth514_1988 ENOG4105S2F Teth514_1991 ENOG4108UTW Plays a role in the regulation of phosphate uptake Teth514_1992 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) Teth514_1993 ENOG4105E2Z phosphate ABC transporter (Permease Teth514_1994 ENOG4105C8U phosphate abc transporter Teth514_1995 ENOG4105CVA phosphate Teth514_1996 ENOG4105BZU Histidine kinase Teth514_1997 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Teth514_1999 ENOG4108BIK prc-barrel domain-containing protein Teth514_2000 ENOG4105E65 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Teth514_2001 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Teth514_2002 ENOG4108AWX Sporulation factor SpoIIGA Teth514_2003 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) Teth514_2004 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) Teth514_2005 ENOG4105K67 small basic protein Teth514_2008 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) Teth514_2009 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) Teth514_2010 ENOG4105CNI cell division protein FtsW Teth514_2012 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) Teth514_2013 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) Teth514_2014 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) Teth514_2015 ENOG4105CJN penicillin-binding protein Teth514_2016 ENOG41068JM cell division protein, FtsL Teth514_2022 ENOG4105C3G gtp-binding protein Teth514_2027 ENOG4105EKQ RNA-directed DNA polymerase Teth514_2030 ENOG4107QKR Dehydrogenase Teth514_2031 ENOG4106Z86 ATP-nad acox kinase Teth514_2033 ENOG4107RUY (E1 component), alpha subunit Teth514_2034 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) Teth514_2036 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) Teth514_2041 ENOG4105DFM M18 family aminopeptidase Teth514_2042 ENOG4105WH1 Two component transcriptional regulator luxr family Teth514_2045 ENOG4105EWC Purine nucleoside phosphorylase Teth514_2046 ENOG4105C98 muts2 protein Teth514_2047 ENOG4105CFP Peptidase U32 Teth514_2049 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) Teth514_2050 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) Teth514_2051 ENOG4108RWN rrna methyltransferase Teth514_2054 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) Teth514_2057 ENOG4105C22 threonyL-tRNA synthetase Teth514_2058 ENOG4108UH6 UPF0754 membrane protein Teth514_2061 ENOG41065U4 response regulator Teth514_2062 ENOG4105XXY Thioredoxin Teth514_2063 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) Teth514_2064 ENOG4105VEQ Cold shock protein Teth514_2065 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) Teth514_2067 ENOG41083MR nifu domain-containing protein Teth514_2068 ENOG4108ZGC gaf domain protein Teth514_2069 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) Teth514_2070 ENOG4107QSE Dipeptidase Teth514_2072 ENOG4107S21 permease Teth514_2075 ENOG4105VUC UPF0237 protein Teth514_2076 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) Teth514_2078 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) Teth514_2080 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ Teth514_2082 ENOG4105CSA Coproporphyrinogen iii oxidase Teth514_2088 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) Teth514_2090 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) Teth514_2093 ENOG4107R1N Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) Teth514_2095 ENOG4105PUK Membrane Teth514_2098 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) Teth514_2099 ENOG4105CM2 brancheD-chain amino acid aminotransferase Teth514_2100 ENOG41084EF Ferredoxin Teth514_2103 ENOG4108W5N phosphatidylglycerophosphatase a Teth514_2104 ENOG4105KQC Competence protein Teth514_2105 ENOG4105DZ1 carboxypeptidase Teth514_2106 ENOG4105CAQ asparagine synthetase Teth514_2110 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) Teth514_2111 ENOG4108WF2 Metal Dependent Phosphohydrolase Teth514_2112 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) Teth514_2113 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control Teth514_2115 ENOG4105K46 50S ribosomal protein l27 Teth514_2117 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) Teth514_2119 ENOG410807C QueT transporter Teth514_2120 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) Teth514_2121 ENOG4105C03 ribonuclease Teth514_2125 ENOG4105DR5 peptidase Teth514_2126 ENOG4108Z5K methylglyoxal synthase Teth514_2127 ENOG4105CNI cell division protein FtsW Teth514_2128 ENOG41083CN Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) Teth514_2129 ENOG4107QMS site-determining protein Teth514_2130 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) Teth514_2131 ENOG4105CJN penicillin-binding protein Teth514_2134 ENOG4105DFF Rod shape-determining protein mreb Teth514_2135 ENOG4105W5Q DNA repair protein (RadC Teth514_2136 ENOG4108Z03 MAF-like protein Teth514_2138 ENOG4107QHI -hydrogenase Teth514_2139 ENOG4107QIZ NADH dehydrogenase Teth514_2141 ENOG4105BZU Histidine kinase Teth514_2142 ENOG410902H NADH dehydrogenase (Ubiquinone), 24 kDa subunit Teth514_2145 ENOG4108R3D Electron transport complex Teth514_2149 ENOG4105E4C Lytic transglycosylase catalytic Teth514_2151 ENOG4107TT5 NLP P60 protein Teth514_2154 ENOG4105E4C Lytic transglycosylase catalytic Teth514_2155 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) Teth514_2156 ENOG4105C2M dna polymerase I Teth514_2161 ENOG4108UIC UPF0340 protein Teth514_2166 ENOG4105D07 Signal peptide peptidase, SppA Teth514_2170 ENOG4105C84 Histidine ammonia-lyase Teth514_2173 ENOG4105DR5 peptidase Teth514_2175 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Teth514_2176 ENOG4105DYB Isoaspartyl dipeptidase Teth514_2177 ENOG4105M3Z response regulator Teth514_2180 ENOG4105BZ1 (ABC) transporter Teth514_2181 ENOG4105BZ1 (ABC) transporter Teth514_2183 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) Teth514_2184 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Teth514_2185 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) Teth514_2187 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase Teth514_2190 ENOG4105F0V Cell wall hydrolase Teth514_2191 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Teth514_2192 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin Teth514_2195 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component Teth514_2197 ENOG4105ETE Transcriptional regulator (LacI family Teth514_2198 ENOG4107URF beta-phospho-glucomutase Teth514_2199 ENOG4105DRS transport system, permease Teth514_2200 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component Teth514_2203 ENOG4107KJX Transcriptional regulator Teth514_2204 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) Teth514_2209 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase Teth514_2211 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) Teth514_2216 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Teth514_2217 ENOG4105BZU Histidine kinase Teth514_2219 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase Teth514_2221 ENOG4108UKJ Cdp-alcohol phosphatidyltransferase Teth514_2224 ENOG4105EKQ RNA-directed DNA polymerase Teth514_2227 ENOG4105C0R drug resistance transporter emrb qaca subfamily Teth514_2228 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) Teth514_2232 ENOG4108K88 Membrane Teth514_2233 ENOG4108KGH TRANSCRIPTIONal Teth514_2235 ENOG4107YJ4 chain length determinant protein Teth514_2236 ENOG4105HTX biosynthesis protein Teth514_2237 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase Teth514_2240 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) Teth514_2251 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) Teth514_2253 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Teth514_2256 ENOG4107QM2 Aldo Keto reductase Teth514_2257 ENOG4108RE9 Phosphodiesterase Teth514_2258 ENOG4108V0P LemA family Teth514_2263 ENOG41084HI prevent-host-death family Teth514_2266 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 Teth514_2276 ENOG4105D3Q Sugar transferase Teth514_2277 ENOG4105C6Y Udp-glucose 6-dehydrogenase Teth514_2278 ENOG4107STW synthase Teth514_2281 ENOG4107EF8 Glycosyl transferase (Group 1 Teth514_2282 ENOG4107T8Q Glycosyl transferase (Group 1 Teth514_2283 ENOG4105CPK Glycosyl transferase (Group 1 Teth514_2291 ENOG4105CJW magnesium transporter Teth514_2293 ENOG4105D2X ABC transporter substrate-binding protein Teth514_2295 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component Teth514_2298 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) Teth514_2299 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) Teth514_2301 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Teth514_2302 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation Teth514_2304 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) Teth514_2307 ENOG4105C5R Aminotransferase Teth514_2309 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) Teth514_2310 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) Teth514_2312 ENOG41090I5 UPF0735 ACT domain-containing protein Teth514_2313 ENOG4105Q2H domain protein Teth514_2316 ENOG4105ZHF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) Teth514_2317 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) Teth514_2319 ENOG4105EC3 peptidase S51, dipeptidase E Teth514_2328 ENOG4107YH3 SUF system FeS assembly protein, NifU family Teth514_2331 ENOG4105DIW FeS assembly protein SUFB Teth514_2332 ENOG4105C3K feS assembly ATPase SufC Teth514_2333 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) Teth514_2338 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) Teth514_2343 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) Teth514_2345 ENOG4105DR5 peptidase Teth514_2347 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) Teth514_2348 ENOG4105CD8 aminopeptidase N Teth514_2351 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 Teth514_2354 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis Teth514_2355 ENOG4105DZ0 fad dependent oxidoreductase Teth514_2356 ENOG4105C8Q Methyl-accepting chemotaxis Teth514_2358 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase Teth514_2359 ENOG4105DPN Oligoendopeptidase f Teth514_2362 ENOG4105M56 Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) Teth514_2365 ENOG4105KXQ Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) Teth514_2371 ENOG4105C2W permease Teth514_2387 ENOG4105CDU Replicative dna helicase Teth514_2388 ENOG4105K9Q Binds to the 23S rRNA (By similarity) Teth514_2392 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) Teth514_2393 ENOG4108UUM single-stranded DNA-binding protein Teth514_2394 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) Teth514_2395 ENOG4105VDK protein, conserved in bacteria Teth514_2396 ENOG4105D8X mechanosensitive ion channel Teth514_2397 ENOG4108ZDA Sporulation protein YyaC Teth514_2399 ENOG4105DDG Cyanophycinase Teth514_2400 ENOG4105CBD Diacylglycerol kinase Teth514_2402 ENOG4105C9B Cysteine desulfurase Teth514_2403 ENOG4105FA0 parb-like partition protein Teth514_2404 ENOG4107QJE Chromosome Partitioning Protein Teth514_2405 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) Teth514_2408 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) Teth514_2410 ENOG4108Z7S Single-stranded nucleic acid binding R3H domain-containing protein Teth514_2411 ENOG4107R4E Membrane Teth514_2412 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) Teth514_2413 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) Teth514_2414 ENOG4105VG0 50S ribosomal protein l34