locus-tag	class	description
Teth514_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Teth514_0002	COG0592	DNA-directed DNA polymerase activity
Teth514_0003	COG2501	S4 domain
Teth514_0007	COG3442	glutamine amidotransferase
Teth514_0009	COG0187	DNA topoisomerase II activity
Teth514_0010	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Teth514_0011	COG1902	pentaerythritol trinitrate reductase activity
Teth514_0012	COG0440	acetolactate synthase activity
Teth514_0014	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Teth514_0016	COG0066	3-isopropylmalate dehydratase activity
Teth514_0017	COG0473	3-isopropylmalate dehydrogenase activity
Teth514_0018	COG0129	dihydroxy-acid dehydratase activity
Teth514_0019	COG0028	Belongs to the TPP enzyme family
Teth514_0024	COG0628	permease
Teth514_0028	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Teth514_0032	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Teth514_0032	COG2199	diguanylate cyclase activity
Teth514_0033	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Teth514_0036	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Teth514_0037	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Teth514_0038	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Teth514_0044	COG0583	DNA-binding transcription factor activity
Teth514_0045	COG2391	methyltransferase activity
Teth514_0047	COG2391	methyltransferase activity
Teth514_0049	COG1940	carbohydrate kinase activity
Teth514_0050	COG0519	Catalyzes the synthesis of GMP from XMP
Teth514_0052	COG1982	Orn Lys Arg decarboxylase major
Teth514_0053	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Teth514_0054	COG3870	Protein conserved in bacteria
Teth514_0056	COG0470	DNA polymerase III
Teth514_0057	COG1774	PSP1 C-terminal conserved region
Teth514_0058	COG2235	arginine
Teth514_0059	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Teth514_0060	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Teth514_0062	COG2002	toxin-antitoxin pair type II binding
Teth514_0063	COG2715	membrane protein required for spore maturation
Teth514_0064	COG0700	Nucleoside recognition
Teth514_0065	COG0617	tRNA 3'-terminal CCA addition
Teth514_0066	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Teth514_0066	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Teth514_0067	COG0084	hydrolase, TatD family'
Teth514_0068	COG3584	3D domain protein
Teth514_0068	COG3583	domain protein
Teth514_0069	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Teth514_0074	COG1191	sigma factor activity
Teth514_0075	COG0489	protein tyrosine kinase activity
Teth514_0075	COG2151	metal-sulfur cluster biosynthetic enzyme
Teth514_0078	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Teth514_0079	COG4656	Part of a membrane complex involved in electron transport
Teth514_0080	COG4658	electron transport chain
Teth514_0081	COG4659	FMN binding
Teth514_0082	COG4660	Part of a membrane complex involved in electron transport
Teth514_0083	COG4657	Part of a membrane complex involved in electron transport
Teth514_0084	COG1245	4Fe-4S binding domain
Teth514_0084	COG2878	Part of a membrane complex involved in electron transport
Teth514_0087	COG0745	RESPONSE REGULATOR receiver
Teth514_0089	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Teth514_0090	COG0254	rRNA binding
Teth514_0091	COG1435	thymidine kinase activity
Teth514_0092	COG3872	metal-dependent enzyme
Teth514_0096	COG0009	L-threonylcarbamoyladenylate synthase
Teth514_0097	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Teth514_0098	COG0698	ribose 5-phosphate isomerase
Teth514_0099	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Teth514_0103	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Teth514_0104	COG0686	Belongs to the AlaDH PNT family
Teth514_0106	COG2385	sporulation resulting in formation of a cellular spore
Teth514_0108	COG1609	Transcriptional regulator
Teth514_0110	COG4786	Flagellar basal body rod
Teth514_0120	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Teth514_0120	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Teth514_0123	COG3775	system Galactitol-specific IIC component
Teth514_0127	COG4948	Mandelate Racemase Muconate Lactonizing
Teth514_0128	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Teth514_0129	COG0800	Aldolase
Teth514_0130	COG2814	Major facilitator Superfamily
Teth514_0131	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Teth514_0131	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Teth514_0132	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Teth514_0134	COG3716	PTS system mannose fructose sorbose family IID component
Teth514_0135	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Teth514_0136	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Teth514_0137	COG0800	Aldolase
Teth514_0138	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Teth514_0139	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Teth514_0140	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Teth514_0141	COG0569	domain protein
Teth514_0144	COG0778	Nitroreductase
Teth514_0147	COG0583	DNA-binding transcription factor activity
Teth514_0154	COG1070	Carbohydrate kinase
Teth514_0155	COG4213	ABC transporter substrate-binding protein
Teth514_0156	COG3344	reverse transcriptase
Teth514_0158	COG4214	carbohydrate transport
Teth514_0161	COG1609	Transcriptional regulator
Teth514_0162	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Teth514_0163	COG1869	D-ribose catabolic process
Teth514_0164	COG1129	ABC transporter
Teth514_0165	COG1172	Belongs to the binding-protein-dependent transport system permease family
Teth514_0166	COG1879	ABC-type sugar transport system periplasmic component
Teth514_0167	COG3344	reverse transcriptase
Teth514_0168	COG1737	Transcriptional regulator
Teth514_0169	COG2190	(PTS) system
Teth514_0170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Teth514_0170	COG1263	PTS System
Teth514_0173	COG2188	Transcriptional regulator
Teth514_0178	COG1735	metal-dependent hydrolase with the TIM-barrel fold
Teth514_0179	COG0626	cystathionine gamma-synthase activity
Teth514_0180	COG3457	Alanine racemase
Teth514_0181	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Teth514_0182	COG1472	Belongs to the glycosyl hydrolase 3 family
Teth514_0185	COG0436	Aminotransferase
Teth514_0186	COG1522	sequence-specific DNA binding
Teth514_0188	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Teth514_0188	COG1918	ferrous iron import across plasma membrane
Teth514_0189	COG1122	ATPase activity
Teth514_0190	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Teth514_0191	COG0310	cobalt ion transport
Teth514_0192	COG0310	cobalt ion transport
Teth514_0193	COG0864	Transcriptional regulator
Teth514_0195	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Teth514_0198	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Teth514_0199	COG1136	(ABC) transporter
Teth514_0200	COG1136	(ABC) transporter
Teth514_0200	COG0577	efflux transmembrane transporter activity
Teth514_0201	COG0179	Fumarylacetoacetate (FAA) hydrolase
Teth514_0202	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
Teth514_0204	COG0420	3'-5' exonuclease activity
Teth514_0205	COG0419	ATPase involved in DNA repair
Teth514_0207	COG0450	alkyl hydroperoxide reductase
Teth514_0212	COG0297	glycogen (starch) synthase activity
Teth514_0216	COG0039	L-malate dehydrogenase activity
Teth514_0221	COG1980	fructose-bisphosphate aldolase activity
Teth514_0221	COG1980	fructose-bisphosphate aldolase activity
Teth514_0223	COG2972	Histidine kinase
Teth514_0224	COG2197	response regulator
Teth514_0225	COG4213	ABC transporter substrate-binding protein
Teth514_0226	COG4213	ABC transporter substrate-binding protein
Teth514_0227	COG1129	ABC transporter
Teth514_0228	COG4214	carbohydrate transport
Teth514_0229	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Teth514_0230	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Teth514_0233	COG0095	Lipoate-protein ligase
Teth514_0234	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Teth514_0236	COG0436	Aminotransferase
Teth514_0237	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Teth514_0238	COG3037	sugar-specific permease SgaT UlaA
Teth514_0241	COG1979	alcohol dehydrogenase
Teth514_0245	COG0640	Transcriptional regulator
Teth514_0251	COG1924	4 iron, 4 sulfur cluster binding
Teth514_0253	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Teth514_0254	COG0390	transport system, permease component
Teth514_0255	COG0495	leucyl-tRNA aminoacylation
Teth514_0256	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
Teth514_0258	COG1522	sequence-specific DNA binding
Teth514_0258	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Teth514_0259	COG2313	pseudouridylate synthase activity
Teth514_0261	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Teth514_0261	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Teth514_0265	COG1447	Phosphotransferase system cellobiose-specific component IIA
Teth514_0266	COG1486	melibiose metabolic process
Teth514_0267	COG2723	6-phospho-beta-galactosidase activity
Teth514_0268	COG2213	PTS system mannitol-specific
Teth514_0269	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Teth514_0269	COG3711	transcriptional antiterminator
Teth514_0272	COG0737	Belongs to the 5'-nucleotidase family
Teth514_0273	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Teth514_0274	COG0730	response to heat
Teth514_0276	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Teth514_0277	COG1121	(ABC) transporter
Teth514_0278	COG0803	Belongs to the bacterial solute-binding protein 9 family
Teth514_0279	COG0735	belongs to the Fur family
Teth514_0280	COG0714	Associated with various cellular activities
Teth514_0283	COG1704	LemA family
Teth514_0287	COG2221	Nitrite and sulphite reductase 4Fe-4S
Teth514_0289	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Teth514_0290	COG0822	iron-sulfur transferase activity
Teth514_0293	COG0116	Belongs to the methyltransferase superfamily
Teth514_0296	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Teth514_0297	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Teth514_0298	COG1120	ATPase activity
Teth514_0299	COG1797	cobyrinic acid a,c-diamide synthase activity
Teth514_0304	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Teth514_0313	COG2875	Belongs to the precorrin methyltransferase family
Teth514_0317	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Teth514_0320	COG0113	porphobilinogen synthase activity
Teth514_0321	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Teth514_0323	COG0310	cobalt ion transport
Teth514_0326	COG1122	ATPase activity
Teth514_0329	COG4555	ABC transporter
Teth514_0338	COG1121	(ABC) transporter
Teth514_0340	COG4555	ABC transporter
Teth514_0341	COG1668	transmembrane transport
Teth514_0346	COG1131	(ABC) transporter
Teth514_0348	COG4566	intracellular signal transduction
Teth514_0350	COG1131	(ABC) transporter
Teth514_0361	COG1121	(ABC) transporter
Teth514_0363	COG4555	ABC transporter
Teth514_0364	COG1668	transmembrane transport
Teth514_0377	COG1363	Peptidase, m42
Teth514_0383	COG3344	reverse transcriptase
Teth514_0385	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Teth514_0385	COG2199	diguanylate cyclase activity
Teth514_0389	COG0840	transmembrane signaling receptor activity
Teth514_0391	COG1228	amidohydrolase
Teth514_0394	COG1486	melibiose metabolic process
Teth514_0397	COG1653	transport
Teth514_0398	COG2972	Histidine kinase
Teth514_0399	COG2207	Transcriptional regulator
Teth514_0399	COG4753	response regulator
Teth514_0400	COG3404	Formiminotransferase-cyclodeaminase
Teth514_0401	COG1744	ABC transporter substrate-binding protein PnrA-like
Teth514_0408	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Teth514_0410	COG0840	transmembrane signaling receptor activity
Teth514_0412	COG1263	PTS System
Teth514_0412	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Teth514_0412	COG2190	(PTS) system
Teth514_0413	COG2190	(PTS) system
Teth514_0414	COG3711	transcriptional antiterminator
Teth514_0415	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Teth514_0424	COG2081	HI0933 family
Teth514_0425	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Teth514_0427	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Teth514_0429	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
Teth514_0430	COG0582	viral genome integration into host DNA
Teth514_0432	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Teth514_0433	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Teth514_0436	COG2323	membrane
Teth514_0437	COG0561	phosphatase activity
Teth514_0438	COG1609	Transcriptional regulator
Teth514_0439	COG0745	RESPONSE REGULATOR receiver
Teth514_0440	COG5002	protein histidine kinase activity
Teth514_0444	COG1592	Rubrerythrin
Teth514_0445	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Teth514_0446	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Teth514_0447	COG1040	competence protein
Teth514_0451	COG4786	Flagellar basal body rod
Teth514_0451	COG1256	bacterial-type flagellum assembly
Teth514_0452	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Teth514_0454	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
Teth514_0455	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Teth514_0461	COG0367	asparagine synthase
Teth514_0464	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Teth514_0465	COG1516	flagellar protein fliS
Teth514_0468	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Teth514_0469	COG0765	amino acid transport
Teth514_0475	COG1827	regulation of RNA biosynthetic process
Teth514_0477	COG0653	protein targeting
Teth514_0478	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Teth514_0479	COG2183	response to ionizing radiation
Teth514_0481	COG0398	Pfam SNARE associated Golgi protein
Teth514_0483	COG2235	arginine
Teth514_0484	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Teth514_0485	COG0549	Belongs to the carbamate kinase family
Teth514_0487	COG3344	reverse transcriptase
Teth514_0488	COG0802	atpase or kinase
Teth514_0489	COG1214	PFAM Peptidase M22, glycoprotease
Teth514_0491	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Teth514_0493	COG0488	(ABC) transporter
Teth514_0498	COG3279	Response regulator of the LytR AlgR family
Teth514_0499	COG3290	protein histidine kinase activity
Teth514_0507	COG1811	Na channel or pump
Teth514_0509	COG1404	Belongs to the peptidase S8 family
Teth514_0512	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Teth514_0513	COG0459	protein refolding
Teth514_0514	COG0517	IMP dehydrogenase activity
Teth514_0514	COG0516	GMP reductase activity
Teth514_0515	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Teth514_0515	COG0519	Catalyzes the synthesis of GMP from XMP
Teth514_0516	COG2252	PERMEase
Teth514_0517	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Teth514_0518	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Teth514_0519	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Teth514_0520	COG0047	phosphoribosylformylglycinamidine synthase activity
Teth514_0522	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Teth514_0524	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Teth514_0526	COG0151	Belongs to the GarS family
Teth514_0528	COG1473	amidohydrolase
Teth514_0529	COG2244	polysaccharide biosynthetic process
Teth514_0531	COG3711	transcriptional antiterminator
Teth514_0533	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Teth514_0534	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Teth514_0535	COG1447	Phosphotransferase system cellobiose-specific component IIA
Teth514_0536	COG4496	protein, YerC YecD
Teth514_0537	COG0210	DNA helicase
Teth514_0539	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Teth514_0542	COG3464	Transposase
Teth514_0546	COG4166	transmembrane transport
Teth514_0547	COG0601	transmembrane transport
Teth514_0548	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Teth514_0549	COG0444	Belongs to the ABC transporter superfamily
Teth514_0550	COG4608	Belongs to the ABC transporter superfamily
Teth514_0551	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Teth514_0555	COG0004	ammonium transporteR
Teth514_0556	COG0347	Belongs to the P(II) protein family
Teth514_0557	COG0505	Belongs to the CarA family
Teth514_0558	COG0067	glutamate synthase
Teth514_0559	COG0069	glutamate synthase activity
Teth514_0559	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Teth514_0560	COG0437	4 iron, 4 sulfur cluster binding
Teth514_0563	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Teth514_0565	COG0351	phosphomethylpyrimidine kinase
Teth514_0566	COG0352	thiamine-phosphate diphosphorylase activity
Teth514_0571	COG0704	Plays a role in the regulation of phosphate uptake
Teth514_0572	COG0410	ABC transporter
Teth514_0575	COG1349	DNA-binding transcription factor activity
Teth514_0577	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Teth514_0577	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Teth514_0577	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Teth514_0580	COG0071	Belongs to the small heat shock protein (HSP20) family
Teth514_0583	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Teth514_0584	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Teth514_0586	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Teth514_0587	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Teth514_0588	COG0745	RESPONSE REGULATOR receiver
Teth514_0589	COG5002	protein histidine kinase activity
Teth514_0590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Teth514_0593	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Teth514_0594	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Teth514_0595	COG2002	toxin-antitoxin pair type II binding
Teth514_0597	COG4466	Protein conserved in bacteria
Teth514_0598	COG1388	LysM domain
Teth514_0600	COG1802	Transcriptional regulator
Teth514_0603	COG0697	spore germination
Teth514_0604	COG0531	amino acid
Teth514_0607	COG3773	Cell wall hydrolase
Teth514_0607	COG3409	Peptidoglycan-binding domain 1 protein
Teth514_0608	COG2959	enzyme of heme biosynthesis
Teth514_0610	COG1181	Belongs to the D-alanine--D-alanine ligase family
Teth514_0612	COG0018	arginyl-trna synthetase
Teth514_0613	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Teth514_0615	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Teth514_0619	COG4608	Belongs to the ABC transporter superfamily
Teth514_0620	COG0444	Belongs to the ABC transporter superfamily
Teth514_0621	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Teth514_0622	COG0601	transmembrane transport
Teth514_0623	COG4166	transmembrane transport
Teth514_0625	COG0667	Aldo Keto reductase
Teth514_0627	COG1012	belongs to the aldehyde dehydrogenase family
Teth514_0627	COG1454	alcohol dehydrogenase
Teth514_0630	COG1846	Transcriptional regulator
Teth514_0632	COG1132	(ABC) transporter
Teth514_0633	COG3859	Proton-coupled thiamine transporter YuaJ
Teth514_0634	COG0671	phosphoesterase, PA-phosphatase related
Teth514_0644	COG1595	DNA-templated transcription, initiation
Teth514_0648	COG1131	(ABC) transporter
Teth514_0650	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Teth514_0650	COG1796	DNA polymerase
Teth514_0651	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Teth514_0651	COG0493	'glutamate synthase
Teth514_0658	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Teth514_0660	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Teth514_0661	COG0505	Belongs to the CarA family
Teth514_0664	COG0165	Argininosuccinate lyase
Teth514_0665	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Teth514_0668	COG1528	Iron-storage protein
Teth514_0672	COG0142	geranyltranstransferase activity
Teth514_0678	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Teth514_0680	COG2033	superoxide reductase activity
Teth514_0681	COG5002	protein histidine kinase activity
Teth514_0682	COG1027	Aspartate ammonia-lyase
Teth514_0683	COG1160	GTP binding
Teth514_0684	COG2814	Major facilitator Superfamily
Teth514_0686	COG3956	TIGRFAM MazG family protein
Teth514_0687	COG0776	regulation of translation
Teth514_0688	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Teth514_0689	COG2385	sporulation resulting in formation of a cellular spore
Teth514_0696	COG1098	S1 RNA binding domain
Teth514_0697	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Teth514_0697	COG0248	Ppx GppA phosphatase
Teth514_0698	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Teth514_0702	COG1396	sequence-specific DNA binding
Teth514_0717	COG0739	heme binding
Teth514_0722	COG4962	Type ii secretion system protein e
Teth514_0730	COG3409	Peptidoglycan-binding domain 1 protein
Teth514_0730	COG3773	Cell wall hydrolase
Teth514_0748	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Teth514_0749	COG3344	reverse transcriptase
Teth514_0752	COG1940	carbohydrate kinase activity
Teth514_0753	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Teth514_0754	COG1175	transmembrane transport
Teth514_0756	COG0395	ABC-type sugar transport system, permease component
Teth514_0758	COG3387	PFAM Glycoside hydrolase 15-related
Teth514_0761	COG2801	Transposase and inactivated derivatives
Teth514_0762	COG3464	Transposase
Teth514_0763	COG3464	Transposase
Teth514_0766	COG0745	RESPONSE REGULATOR receiver
Teth514_0767	COG2205	protein histidine kinase activity
Teth514_0770	COG2217	Heavy metal translocating P-type atpase
Teth514_0771	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Teth514_0774	COG2217	Heavy metal translocating P-type atpase
Teth514_0775	COG5001	Diguanylate cyclase
Teth514_0775	COG3300	MHYT domain
Teth514_0780	COG1063	alcohol dehydrogenase
Teth514_0785	COG1131	(ABC) transporter
Teth514_0788	COG0697	spore germination
Teth514_0790	COG2208	phosphoserine phosphatase activity
Teth514_0791	COG0037	tRNA processing
Teth514_0794	COG3852	Histidine kinase
Teth514_0797	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Teth514_0799	COG5016	pyruvate
Teth514_0799	COG0511	ligase activity, forming carbon-carbon bonds
Teth514_0800	COG4684	Psort location CytoplasmicMembrane, score
Teth514_0801	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Teth514_0802	COG0531	amino acid
Teth514_0803	COG0697	spore germination
Teth514_0808	COG5322	oxidoreductase activity
Teth514_0808	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Teth514_0809	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Teth514_0811	COG0302	gtp cyclohydrolase
Teth514_0812	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Teth514_0813	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Teth514_0814	COG0720	synthase
Teth514_0815	COG1489	DNA binding
Teth514_0816	COG0823	Involved in the tonB-independent uptake of proteins
Teth514_0816	COG4946	Tricorn protease homolog
Teth514_0816	COG1506	peptidase
Teth514_0818	COG4224	UPF0291 protein
Teth514_0822	COG3706	GGDEF domain
Teth514_0822	COG0745	RESPONSE REGULATOR receiver
Teth514_0823	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Teth514_0823	COG3711	transcriptional antiterminator
Teth514_0824	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Teth514_0824	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Teth514_0824	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Teth514_0825	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Teth514_0825	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Teth514_0825	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Teth514_0826	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Teth514_0827	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Teth514_0828	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Teth514_0829	COG3344	reverse transcriptase
Teth514_0830	COG0281	malic enzyme
Teth514_0833	COG3880	PFAM UvrB UvrC protein
Teth514_0834	COG3869	Catalyzes the specific phosphorylation of arginine residues in
Teth514_0835	COG0542	response to heat
Teth514_0836	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Teth514_0838	COG4956	integral membrane protein (PIN domain superfamily)
Teth514_0839	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Teth514_0841	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Teth514_0845	COG1045	serine acetyltransferase
Teth514_0846	COG0215	cysteine-tRNA ligase activity
Teth514_0848	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Teth514_0849	COG3688	RNA-binding protein containing a PIN domain
Teth514_0850	COG1595	DNA-templated transcription, initiation
Teth514_0851	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Teth514_0853	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Teth514_0854	COG0250	Participates in transcription elongation, termination and antitermination
Teth514_0855	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Teth514_0861	COG1358	cellular component organization or biogenesis
Teth514_0862	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Teth514_0864	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Teth514_0865	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Teth514_0866	COG0051	transcription antitermination factor activity, RNA binding
Teth514_0868	COG0088	Forms part of the polypeptide exit tunnel
Teth514_0869	COG0089	rRNA binding
Teth514_0870	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Teth514_0871	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Teth514_0872	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Teth514_0873	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Teth514_0875	COG0255	Belongs to the universal ribosomal protein uL29 family
Teth514_0876	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Teth514_0877	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Teth514_0878	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Teth514_0879	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Teth514_0880	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Teth514_0881	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Teth514_0883	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Teth514_0884	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Teth514_0885	COG0200	Binds to the 23S rRNA
Teth514_0886	COG0201	protein transport
Teth514_0887	COG0563	adenylate kinase activity
Teth514_0890	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Teth514_0892	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Teth514_0893	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Teth514_0894	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Teth514_0895	COG0202	RNA polymerase activity
Teth514_0896	COG0203	ribosomal protein L17
Teth514_0897	COG1122	ATPase activity
Teth514_0898	COG1122	ATPase activity
Teth514_0899	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Teth514_0900	COG0101	tRNA pseudouridine synthase activity
Teth514_0901	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Teth514_0902	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Teth514_0907	COG2033	superoxide reductase activity
Teth514_0909	COG1966	Carbon starvation protein
Teth514_0910	COG1115	amino acid carrier protein
Teth514_0913	COG1320	monovalent cation:proton antiporter activity
Teth514_0917	COG0651	ATP synthesis coupled electron transport
Teth514_0918	COG0651	ATP synthesis coupled electron transport
Teth514_0920	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Teth514_0925	COG1388	LysM domain
Teth514_0925	COG1705	Flagellar rod assembly protein muramidase FlgJ
Teth514_0927	COG0546	phosphoglycolate phosphatase activity
Teth514_0928	COG0714	Associated with various cellular activities
Teth514_0930	COG1305	Transglutaminase-like
Teth514_0934	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
Teth514_0936	COG3426	butyrate kinase activity
Teth514_0937	COG0280	phosphate acetyltransferase
Teth514_0938	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Teth514_0939	COG3426	butyrate kinase activity
Teth514_0945	COG0280	phosphate acetyltransferase
Teth514_0948	COG0204	Acyl-transferase
Teth514_0948	COG0318	PFAM AMP-dependent synthetase and ligase
Teth514_0950	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Teth514_0951	COG0432	Pfam Uncharacterised protein family UPF0047
Teth514_0952	COG1793	dna ligase
Teth514_0953	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
Teth514_0961	COG0736	holo-[acyl-carrier-protein] synthase activity
Teth514_0962	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Teth514_0962	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Teth514_0964	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Teth514_0966	COG2337	Toxic component of a toxin-antitoxin (TA) module
Teth514_0967	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Teth514_0968	COG3959	Transketolase, thiamine diphosphate binding domain
Teth514_0969	COG3958	Transketolase
Teth514_0971	COG0205	6-phosphofructokinase activity
Teth514_0972	COG1757	Na H antiporter
Teth514_0973	COG1773	rubredoxin
Teth514_0975	COG0460	homoserine dehydrogenase
Teth514_0977	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Teth514_0978	COG0673	inositol 2-dehydrogenase activity
Teth514_0979	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
Teth514_0979	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Teth514_0980	COG3459	Glycosyltransferase 36 associated
Teth514_0981	COG1131	(ABC) transporter
Teth514_0986	COG1082	Xylose isomerase domain protein TIM barrel
Teth514_0988	COG0673	inositol 2-dehydrogenase activity
Teth514_0990	COG1172	Belongs to the binding-protein-dependent transport system permease family
Teth514_0992	COG1940	carbohydrate kinase activity
Teth514_0993	COG0673	inositol 2-dehydrogenase activity
Teth514_1000	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Teth514_1001	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Teth514_1004	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Teth514_1007	COG0140	phosphoribosyl-ATP diphosphatase activity
Teth514_1007	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Teth514_1008	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Teth514_1010	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Teth514_1011	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
Teth514_1013	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Teth514_1018	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
Teth514_1019	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Teth514_1022	COG0446	pyridine nucleotide-disulphide oxidoreductase
Teth514_1025	COG2376	Dihydroxyacetone kinase
Teth514_1027	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Teth514_1027	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Teth514_1027	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
Teth514_1029	COG0443	Heat shock 70 kDa protein
Teth514_1036	COG0849	cell division
Teth514_1040	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Teth514_1041	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Teth514_1042	COG0019	diaminopimelate decarboxylase activity
Teth514_1044	COG3842	ATPase activity
Teth514_1045	COG3835	regulator
Teth514_1046	COG2884	Cell division ATP-binding protein ftsE
Teth514_1047	COG2177	Part of the ABC transporter FtsEX involved in
Teth514_1048	COG0739	heme binding
Teth514_1049	COG0793	Belongs to the peptidase S41A family
Teth514_1049	COG3409	Peptidoglycan-binding domain 1 protein
Teth514_1050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Teth514_1051	COG2045	Belongs to the ComB family
Teth514_1052	COG0556	nucleotide-excision repair
Teth514_1056	COG0768	penicillin binding
Teth514_1059	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Teth514_1061	COG1940	carbohydrate kinase activity
Teth514_1062	COG0318	PFAM AMP-dependent synthetase and ligase
Teth514_1065	COG2078	PFAM AMMECR1 domain protein
Teth514_1065	COG3885	ferrous iron binding
Teth514_1073	COG0673	inositol 2-dehydrogenase activity
Teth514_1074	COG0673	inositol 2-dehydrogenase activity
Teth514_1078	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Teth514_1079	COG1349	DNA-binding transcription factor activity
Teth514_1080	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Teth514_1081	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Teth514_1086	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
Teth514_1087	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Teth514_1088	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Teth514_1089	COG1940	carbohydrate kinase activity
Teth514_1095	COG3250	beta-galactosidase activity
Teth514_1096	COG0383	alpha-mannosidase activity
Teth514_1099	COG1653	transport
Teth514_1100	COG1175	transmembrane transport
Teth514_1101	COG0395	ABC-type sugar transport system, permease component
Teth514_1103	COG4977	sequence-specific DNA binding
Teth514_1103	COG1917	Cupin 2, conserved barrel domain protein
Teth514_1105	COG0733	neurotransmitter:sodium symporter activity
Teth514_1112	COG0768	penicillin binding
Teth514_1115	COG2182	Extracellular solute-binding protein
Teth514_1118	COG1621	beta-fructofuranosidase activity
Teth514_1119	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Teth514_1120	COG1609	Transcriptional regulator
Teth514_1124	COG2226	methyltransferase
Teth514_1127	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Teth514_1128	COG0489	protein tyrosine kinase activity
Teth514_1130	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Teth514_1131	COG0446	pyridine nucleotide-disulphide oxidoreductase
Teth514_1133	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Teth514_1134	COG1120	ATPase activity
Teth514_1138	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Teth514_1138	COG1918	ferrous iron import across plasma membrane
Teth514_1140	COG1918	ferrous iron import across plasma membrane
Teth514_1140	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Teth514_1141	COG2199	diguanylate cyclase activity
Teth514_1141	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Teth514_1146	COG3447	MASE1 domain protein
Teth514_1146	COG5001	Diguanylate cyclase
Teth514_1146	COG5002	protein histidine kinase activity
Teth514_1148	COG0586	Pfam SNARE associated Golgi protein
Teth514_1149	COG2608	mercury ion transmembrane transporter activity
Teth514_1150	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Teth514_1155	COG0745	RESPONSE REGULATOR receiver
Teth514_1156	COG2205	protein histidine kinase activity
Teth514_1158	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Teth514_1159	COG0037	tRNA processing
Teth514_1162	COG2217	Heavy metal translocating P-type atpase
Teth514_1163	COG2608	mercury ion transmembrane transporter activity
Teth514_1166	COG2217	Heavy metal translocating P-type atpase
Teth514_1172	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Teth514_1174	COG1752	Esterase of the alpha-beta hydrolase superfamily
Teth514_1176	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Teth514_1181	COG2182	Extracellular solute-binding protein
Teth514_1182	COG1175	transmembrane transport
Teth514_1183	COG3833	ABC-type maltose transport systems, permease component
Teth514_1186	COG1426	Protein conserved in bacteria
Teth514_1187	COG0366	Alpha amylase catalytic
Teth514_1190	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Teth514_1191	COG4109	DRTGG domain
Teth514_1194	COG0205	6-phosphofructokinase activity
Teth514_1197	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Teth514_1199	COG0534	Mate efflux family protein
Teth514_1200	COG0471	metal ion transport
Teth514_1200	COG3273	potassium ion transport
Teth514_1201	COG1125	glycine betaine transport
Teth514_1201	COG0517	IMP dehydrogenase activity
Teth514_1202	COG1174	glycine betaine transport
Teth514_1204	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Teth514_1206	COG2195	Cleaves the N-terminal amino acid of tripeptides
Teth514_1207	COG0778	Nitroreductase
Teth514_1209	COG0058	SHG alpha-glucan phosphorylase activity
Teth514_1210	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Teth514_1210	COG0646	methionine synthase
Teth514_1211	COG0646	methionine synthase
Teth514_1211	COG1410	methionine synthase
Teth514_1212	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Teth514_1213	COG3546	catalase activity
Teth514_1216	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Teth514_1234	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Teth514_1234	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Teth514_1243	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Teth514_1251	COG4626	Terminase
Teth514_1251	COG1802	Transcriptional regulator
Teth514_1252	COG4695	Portal protein
Teth514_1269	COG4824	toxin secretion phage lysis holin
Teth514_1276	COG2217	Heavy metal translocating P-type atpase
Teth514_1284	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Teth514_1285	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Teth514_1288	COG0564	pseudouridine synthase activity
Teth514_1290	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Teth514_1297	COG1067	ATP-dependent peptidase activity
Teth514_1298	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Teth514_1299	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Teth514_1300	COG2720	vancomycin resistance protein
Teth514_1302	COG0561	phosphatase activity
Teth514_1303	COG1254	Belongs to the acylphosphatase family
Teth514_1305	COG2390	Transcriptional regulator
Teth514_1307	COG0126	phosphoglycerate kinase activity
Teth514_1311	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Teth514_1312	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Teth514_1313	COG0358	DNA primase activity
Teth514_1314	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Teth514_1316	COG2384	SAM-dependent methyltransferase
Teth514_1317	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Teth514_1318	COG0813	purine-nucleoside phosphorylase activity
Teth514_1319	COG1482	cell wall glycoprotein biosynthetic process
Teth514_1320	COG0475	glutathione-regulated potassium exporter activity
Teth514_1323	COG0701	Predicted permease
Teth514_1325	COG3344	reverse transcriptase
Teth514_1330	COG0463	Glycosyl transferase, family 2
Teth514_1332	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Teth514_1333	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Teth514_1334	COG0537	adenosine 5'-monophosphoramidase activity
Teth514_1335	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Teth514_1340	COG1702	phosphate starvation-inducible protein PhoH
Teth514_1341	COG1480	7TM receptor with intracellular HD hydrolase
Teth514_1342	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Teth514_1343	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Teth514_1344	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Teth514_1348	COG0423	glycine-tRNA ligase activity
Teth514_1349	COG0517	IMP dehydrogenase activity
Teth514_1350	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Teth514_1351	COG0574	Belongs to the PEP-utilizing enzyme family
Teth514_1351	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Teth514_1353	COG0557	exoribonuclease II activity
Teth514_1355	COG1132	(ABC) transporter
Teth514_1365	COG1132	(ABC) transporter
Teth514_1370	COG1132	(ABC) transporter
Teth514_1374	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
Teth514_1377	COG0693	protein deglycase activity
Teth514_1379	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Teth514_1380	COG2414	aldehyde ferredoxin oxidoreductase
Teth514_1383	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Teth514_1389	COG0521	Mo-molybdopterin cofactor biosynthetic process
Teth514_1390	COG0303	'Molybdopterin
Teth514_1391	COG1910	domain protein
Teth514_1397	COG1129	ABC transporter
Teth514_1401	COG2267	carboxylic ester hydrolase activity
Teth514_1405	COG0584	glycerophosphoryl diester phosphodiesterase
Teth514_1407	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Teth514_1411	COG3069	C4-dicarboxylate transmembrane transporter activity
Teth514_1413	COG0426	domain, Protein
Teth514_1414	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Teth514_1416	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Teth514_1417	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Teth514_1418	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Teth514_1421	COG1760	l-serine dehydratase
Teth514_1422	COG1164	Oligoendopeptidase f
Teth514_1424	COG1605	Chorismate mutase
Teth514_1424	COG0077	Prephenate dehydratase
Teth514_1425	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Teth514_1426	COG0287	Prephenate dehydrogenase
Teth514_1427	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Teth514_1429	COG3773	Cell wall hydrolase
Teth514_1429	COG3409	Peptidoglycan-binding domain 1 protein
Teth514_1430	COG2119	membrane
Teth514_1434	COG0785	Cytochrome C biogenesis protein
Teth514_1435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Teth514_1436	COG3118	belongs to the thioredoxin family
Teth514_1437	COG1982	Orn Lys Arg decarboxylase major
Teth514_1440	COG2385	sporulation resulting in formation of a cellular spore
Teth514_1441	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Teth514_1444	COG1739	Uncharacterized protein family UPF0029
Teth514_1448	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Teth514_1449	COG0217	transcriptional regulatory protein
Teth514_1450	COG0835	chemotaxis
Teth514_1452	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Teth514_1453	COG0632	four-way junction helicase activity
Teth514_1454	COG2255	four-way junction helicase activity
Teth514_1461	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Teth514_1462	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Teth514_1463	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Teth514_1463	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Teth514_1465	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Teth514_1465	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Teth514_1470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Teth514_1474	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Teth514_1475	COG1937	Protein conserved in bacteria
Teth514_1476	COG3118	belongs to the thioredoxin family
Teth514_1477	COG3804	dihydrodipicolinate reductase
Teth514_1479	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Teth514_1481	COG5012	cobalamin binding
Teth514_1483	COG3457	Alanine racemase
Teth514_1485	COG1959	2 iron, 2 sulfur cluster binding
Teth514_1486	COG0482	sulfurtransferase activity
Teth514_1488	COG0628	permease
Teth514_1489	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Teth514_1490	COG4472	Bacterial protein of unknown function (DUF965)
Teth514_1492	COG3906	Belongs to the UPF0473 family
Teth514_1493	COG0735	belongs to the Fur family
Teth514_1494	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Teth514_1495	COG3679	Belongs to the UPF0342 family
Teth514_1496	COG4708	membrane
Teth514_1497	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Teth514_1500	COG0768	penicillin binding
Teth514_1501	COG1191	sigma factor activity
Teth514_1503	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Teth514_1508	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Teth514_1519	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Teth514_1521	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Teth514_1522	COG0006	proline dipeptidase activity
Teth514_1523	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Teth514_1525	COG3854	ATPases associated with a variety of cellular activities
Teth514_1533	COG1302	Protein conserved in bacteria
Teth514_1534	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Teth514_1535	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Teth514_1538	COG0142	geranyltranstransferase activity
Teth514_1540	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Teth514_1541	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Teth514_1542	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Teth514_1544	COG0497	DNA recombination
Teth514_1545	COG0750	zinc metalloprotease
Teth514_1553	COG1379	DNA repair
Teth514_1554	COG1300	Membrane
Teth514_1555	COG4974	Belongs to the 'phage' integrase family
Teth514_1556	COG1686	Belongs to the peptidase S11 family
Teth514_1557	COG1366	Belongs to the anti-sigma-factor antagonist family
Teth514_1558	COG2172	sigma factor antagonist activity
Teth514_1560	COG3360	Dodecin
Teth514_1565	COG1994	Peptidase M50
Teth514_1566	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Teth514_1567	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Teth514_1568	COG4086	secreted protein
Teth514_1570	COG3874	Sporulation protein YtfJ
Teth514_1571	COG1301	dicarboxylic acid transport
Teth514_1572	COG1030	water channel activity
Teth514_1573	COG4864	UPF0365 protein
Teth514_1575	COG1686	Belongs to the peptidase S11 family
Teth514_1577	COG0445	tRNA wobble uridine modification
Teth514_1578	COG1187	pseudouridine synthase activity
Teth514_1580	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Teth514_1581	COG0010	Belongs to the arginase family
Teth514_1583	COG1705	Flagellar rod assembly protein muramidase FlgJ
Teth514_1583	COG1388	LysM domain
Teth514_1585	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Teth514_1587	COG0674	pyruvate-flavodoxin oxidoreductase activity
Teth514_1587	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Teth514_1588	COG1013	pyruvate-flavodoxin oxidoreductase activity
Teth514_1592	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Teth514_1593	COG1914	H( )-stimulated, divalent metal cation uptake system
Teth514_1594	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Teth514_1595	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Teth514_1596	COG1984	allophanate hydrolase subunit 2
Teth514_1597	COG4336	lyase activity
Teth514_1600	COG0406	alpha-ribazole phosphatase activity
Teth514_1601	COG2081	HI0933 family
Teth514_1604	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Teth514_1606	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Teth514_1608	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Teth514_1609	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Teth514_1611	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Teth514_1613	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Teth514_1614	COG1923	regulation of RNA biosynthetic process
Teth514_1615	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Teth514_1616	COG0328	RNA-DNA hybrid ribonuclease activity
Teth514_1617	COG4974	Belongs to the 'phage' integrase family
Teth514_1618	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
Teth514_1619	COG0464	growth
Teth514_1620	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Teth514_1622	COG0613	PHP domain protein
Teth514_1623	COG2359	stage V sporulation protein S
Teth514_1624	COG1692	metallophosphoesterase
Teth514_1626	COG2137	regulation of response to DNA damage stimulus
Teth514_1627	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Teth514_1629	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Teth514_1631	COG1674	ftsk spoiiie
Teth514_1633	COG0740	serine-type endopeptidase activity
Teth514_1634	COG0527	aspartate kinase activity
Teth514_1636	COG0756	dUTP diphosphatase activity
Teth514_1637	COG0612	Peptidase, M16
Teth514_1638	COG0726	polysaccharide deacetylase
Teth514_1640	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Teth514_1641	COG0196	riboflavin kinase activity
Teth514_1642	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Teth514_1644	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Teth514_1647	COG2740	Nucleic-acid-binding protein implicated in transcription termination
Teth514_1648	COG0195	Participates in both transcription termination and antitermination
Teth514_1650	COG2176	DNA-directed DNA polymerase activity
Teth514_1652	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Teth514_1653	COG0750	zinc metalloprotease
Teth514_1655	COG4589	Belongs to the CDS family
Teth514_1656	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Teth514_1658	COG0233	cytoplasmic translational termination
Teth514_1659	COG0528	UMP kinase activity
Teth514_1660	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Teth514_1664	COG1191	sigma factor activity
Teth514_1665	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Teth514_1666	COG1776	CheC inhibitor of MCP methylation
Teth514_1667	COG0835	chemotaxis
Teth514_1668	COG2198	Histidine kinase
Teth514_1668	COG0643	Histidine kinase
Teth514_1669	COG2201	protein-glutamate methylesterase activity
Teth514_1671	COG0455	bacterial-type flagellum organization
Teth514_1672	COG1419	protein localization to endoplasmic reticulum
Teth514_1673	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Teth514_1674	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Teth514_1675	COG1684	flagellar biosynthetic protein fliR
Teth514_1676	COG1987	bacterial-type flagellum assembly
Teth514_1677	COG1338	Plays a role in the flagellum-specific transport system
Teth514_1679	COG2201	protein-glutamate methylesterase activity
Teth514_1680	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Teth514_1680	COG1776	CheC inhibitor of MCP methylation
Teth514_1681	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Teth514_1683	COG1582	Flagellar protein (FlbD)
Teth514_1686	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Teth514_1690	COG1157	protein secretion by the type III secretion system
Teth514_1692	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Teth514_1693	COG1766	The M ring may be actively involved in energy transduction
Teth514_1694	COG1677	Flagellar hook-basal body complex protein FliE
Teth514_1696	COG1815	bacterial-type flagellum-dependent cell motility
Teth514_1700	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Teth514_1701	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Teth514_1701	COG0758	DNA mediated transformation
Teth514_1702	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Teth514_1703	COG0792	nuclease activity
Teth514_1704	COG0180	Tryptophanyl-tRNA synthetase
Teth514_1705	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Teth514_1706	COG0606	chelatase, subunit chli
Teth514_1708	COG0335	large ribosomal subunit rRNA binding
Teth514_1709	COG0336	Belongs to the RNA methyltransferase TrmD family
Teth514_1710	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Teth514_1711	COG1837	Belongs to the UPF0109 family
Teth514_1713	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Teth514_1714	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
Teth514_1715	COG0552	protein localization to endoplasmic reticulum
Teth514_1718	COG2359	stage V sporulation protein S
Teth514_1720	COG0571	ribonuclease III activity
Teth514_1721	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Teth514_1722	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Teth514_1723	COG1028	Short-chain dehydrogenase reductase Sdr
Teth514_1724	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Teth514_1725	COG2070	2-Nitropropane dioxygenase
Teth514_1726	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Teth514_1728	COG2030	dehydratase
Teth514_1729	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Teth514_1730	COG1399	metal-binding, possibly nucleic acid-binding protein
Teth514_1731	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Teth514_1732	COG0280	phosphate acetyltransferase
Teth514_1734	COG3314	Sporulation integral membrane protein YlbJ
Teth514_1736	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Teth514_1737	COG0742	ribosomal rna small subunit methyltransferase
Teth514_1740	COG1307	EDD domain protein, DegV family
Teth514_1741	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Teth514_1742	COG1461	Dihydroxyacetone kinase
Teth514_1743	COG1302	Protein conserved in bacteria
Teth514_1747	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Teth514_1748	COG1162	GTPase activity
Teth514_1749	COG0515	serine threonine protein kinase
Teth514_1749	COG2815	serine threonine protein kinase
Teth514_1750	COG0631	protein serine/threonine phosphatase activity
Teth514_1751	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Teth514_1752	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Teth514_1752	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Teth514_1753	COG2738	Putative neutral zinc metallopeptidase
Teth514_1755	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Teth514_1758	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Teth514_1759	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Teth514_1761	COG0194	GDP metabolic process
Teth514_1763	COG1561	YicC-like family, N-terminal region
Teth514_1764	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Teth514_1765	COG2814	Major facilitator Superfamily
Teth514_1769	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Teth514_1770	COG2011	ABC-type metal ion transport system permease component
Teth514_1774	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Teth514_1777	COG1573	uracil-dna glycosylase
Teth514_1779	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Teth514_1780	COG0037	tRNA processing
Teth514_1781	COG3103	Sh3 type 3 domain protein
Teth514_1781	COG0366	Alpha amylase catalytic
Teth514_1783	COG1028	Short-chain dehydrogenase reductase Sdr
Teth514_1784	COG1181	Belongs to the D-alanine--D-alanine ligase family
Teth514_1787	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Teth514_1788	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Teth514_1789	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Teth514_1792	COG4608	Belongs to the ABC transporter superfamily
Teth514_1793	COG0444	Belongs to the ABC transporter superfamily
Teth514_1795	COG0601	transmembrane transport
Teth514_1796	COG4166	transmembrane transport
Teth514_1807	COG1187	pseudouridine synthase activity
Teth514_1808	COG1028	Short-chain dehydrogenase reductase Sdr
Teth514_1810	COG0037	tRNA processing
Teth514_1813	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Teth514_1815	COG0543	2 iron, 2 sulfur cluster binding
Teth514_1817	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Teth514_1818	COG0540	Belongs to the ATCase OTCase family
Teth514_1819	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Teth514_1821	COG0564	pseudouridine synthase activity
Teth514_1822	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Teth514_1830	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Teth514_1843	COG1970	mechanosensitive ion channel activity
Teth514_1846	COG0778	Nitroreductase
Teth514_1847	COG1595	DNA-templated transcription, initiation
Teth514_1850	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
Teth514_1852	COG0346	lactoylglutathione lyase activity
Teth514_1853	COG1703	isobutyryl-CoA mutase activity
Teth514_1860	COG0626	cystathionine gamma-synthase activity
Teth514_1861	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Teth514_1862	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Teth514_1867	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Teth514_1868	COG0512	Glutamine amidotransferase of anthranilate synthase
Teth514_1868	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Teth514_1878	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Teth514_1880	COG1122	ATPase activity
Teth514_1881	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Teth514_1883	COG2188	Transcriptional regulator
Teth514_1884	COG0235	Class ii aldolase
Teth514_1885	COG0402	S-adenosylhomocysteine deaminase activity
Teth514_1886	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Teth514_1888	COG3599	regulation of cell shape
Teth514_1889	COG2302	S4 RNA-binding domain
Teth514_1891	COG1799	cell septum assembly
Teth514_1892	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Teth514_1895	COG2610	gluconate transmembrane transporter activity
Teth514_1896	COG1929	Belongs to the glycerate kinase type-1 family
Teth514_1897	COG3835	regulator
Teth514_1903	COG0632	four-way junction helicase activity
Teth514_1907	COG1461	Dihydroxyacetone kinase
Teth514_1909	COG2376	Dihydroxyacetone kinase
Teth514_1914	COG1012	belongs to the aldehyde dehydrogenase family
Teth514_1917	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Teth514_1919	COG0613	PHP domain protein
Teth514_1921	COG0546	phosphoglycolate phosphatase activity
Teth514_1922	COG0698	ribose 5-phosphate isomerase
Teth514_1923	COG3958	Transketolase
Teth514_1924	COG3959	Transketolase, thiamine diphosphate binding domain
Teth514_1925	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Teth514_1932	COG1120	ATPase activity
Teth514_1933	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Teth514_1934	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Teth514_1935	COG1454	alcohol dehydrogenase
Teth514_1936	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Teth514_1937	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Teth514_1938	COG4810	utilization protein
Teth514_1939	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Teth514_1940	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Teth514_1942	COG1012	belongs to the aldehyde dehydrogenase family
Teth514_1944	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
Teth514_1946	COG4820	ethanolamine utilization protein (EutJ)
Teth514_1947	COG4869	propanediol catabolic process
Teth514_1948	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Teth514_1955	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Teth514_1956	COG1971	Probably functions as a manganese efflux pump
Teth514_1958	COG2197	response regulator
Teth514_1959	COG2972	Histidine kinase
Teth514_1965	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
Teth514_1971	COG1131	(ABC) transporter
Teth514_1973	COG0653	protein targeting
Teth514_1974	COG0531	amino acid
Teth514_1977	COG0745	RESPONSE REGULATOR receiver
Teth514_1991	COG0704	Plays a role in the regulation of phosphate uptake
Teth514_1992	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Teth514_1993	COG0581	inorganic phosphate transmembrane transporter activity
Teth514_1994	COG0573	inorganic phosphate transmembrane transporter activity
Teth514_1995	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Teth514_1996	COG5002	protein histidine kinase activity
Teth514_1997	COG0745	RESPONSE REGULATOR receiver
Teth514_1999	COG1873	PFAM PRC-barrel domain
Teth514_2000	COG1191	sigma factor activity
Teth514_2001	COG1191	sigma factor activity
Teth514_2003	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Teth514_2004	COG0849	cell division
Teth514_2005	COG3856	small basic protein
Teth514_2008	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Teth514_2009	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Teth514_2010	COG0772	Belongs to the SEDS family
Teth514_2012	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Teth514_2013	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Teth514_2014	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Teth514_2015	COG0768	penicillin binding
Teth514_2016	COG3116	cell division
Teth514_2019	COG0612	Peptidase, M16
Teth514_2020	COG0612	Peptidase, M16
Teth514_2022	COG0012	GTP binding
Teth514_2027	COG3344	reverse transcriptase
Teth514_2030	COG0508	dehydrogenase complex catalyzes the overall conversion of
Teth514_2031	COG3199	ATP-NAD kinase
Teth514_2032	COG0022	dehydrogenase e1 component
Teth514_2033	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Teth514_2034	COG0459	protein refolding
Teth514_2036	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Teth514_2038	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Teth514_2041	COG1362	aminopeptidase activity
Teth514_2042	COG2197	response regulator
Teth514_2045	COG1683	Conserved Protein
Teth514_2046	COG1193	negative regulation of DNA recombination
Teth514_2047	COG0826	peptidase U32
Teth514_2049	COG0072	phenylalanine-tRNA ligase activity
Teth514_2049	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Teth514_2050	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Teth514_2051	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Teth514_2054	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Teth514_2057	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Teth514_2058	COG4399	Belongs to the UPF0754 family
Teth514_2061	COG0745	RESPONSE REGULATOR receiver
Teth514_2062	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Teth514_2063	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Teth514_2064	COG1278	Cold shock
Teth514_2065	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Teth514_2067	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Teth514_2068	COG1956	GAF domain-containing protein
Teth514_2069	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Teth514_2070	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Teth514_2072	COG0701	Predicted permease
Teth514_2075	COG3830	Belongs to the UPF0237 family
Teth514_2076	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Teth514_2078	COG0484	heat shock protein binding
Teth514_2080	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Teth514_2082	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Teth514_2088	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Teth514_2090	COG0268	Binds directly to 16S ribosomal RNA
Teth514_2093	COG1234	tRNA 3'-trailer cleavage
Teth514_2095	COG4720	Psort location CytoplasmicMembrane, score
Teth514_2098	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Teth514_2099	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Teth514_2103	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Teth514_2104	COG1555	photosystem II stabilization
Teth514_2104	COG1596	polysaccharide export
Teth514_2105	COG1686	Belongs to the peptidase S11 family
Teth514_2106	COG0367	asparagine synthase
Teth514_2110	COG0799	negative regulation of ribosome biogenesis
Teth514_2111	COG1713	HD superfamily hydrolase involved in NAD metabolism
Teth514_2112	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Teth514_2113	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Teth514_2115	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Teth514_2117	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Teth514_2119	COG4708	membrane
Teth514_2120	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Teth514_2121	COG1530	ribonuclease E activity
Teth514_2124	COG1994	Peptidase M50
Teth514_2124	COG0517	IMP dehydrogenase activity
Teth514_2125	COG0739	heme binding
Teth514_2126	COG1803	Methylglyoxal synthase
Teth514_2127	COG0772	Belongs to the SEDS family
Teth514_2128	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Teth514_2129	COG2894	cell division
Teth514_2130	COG0850	regulation of cytokinetic process
Teth514_2131	COG0768	penicillin binding
Teth514_2134	COG1077	Cell shape determining protein MreB Mrl
Teth514_2135	COG2003	Belongs to the UPF0758 family
Teth514_2136	COG0424	maF-like protein
Teth514_2141	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Teth514_2141	COG4191	Histidine kinase
Teth514_2145	COG2878	Part of a membrane complex involved in electron transport
Teth514_2149	COG0741	lytic transglycosylase activity
Teth514_2151	COG0791	NLP P60 protein
Teth514_2154	COG0741	lytic transglycosylase activity
Teth514_2155	COG0237	dephospho-CoA kinase activity
Teth514_2156	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Teth514_2156	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Teth514_2161	COG4475	Protein of unknown function (DUF436)
Teth514_2166	COG0616	signal peptide processing
Teth514_2170	COG2986	histidine ammonia-lyase
Teth514_2173	COG0739	heme binding
Teth514_2175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Teth514_2176	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Teth514_2180	COG1132	(ABC) transporter
Teth514_2181	COG1132	(ABC) transporter
Teth514_2183	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Teth514_2184	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Teth514_2185	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Teth514_2187	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Teth514_2190	COG3773	Cell wall hydrolase
Teth514_2190	COG3409	Peptidoglycan-binding domain 1 protein
Teth514_2191	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Teth514_2191	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Teth514_2192	COG1404	Belongs to the peptidase S8 family
Teth514_2195	COG0395	ABC-type sugar transport system, permease component
Teth514_2198	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Teth514_2199	COG0395	ABC-type sugar transport system, permease component
Teth514_2200	COG1175	transmembrane transport
Teth514_2203	COG1609	Transcriptional regulator
Teth514_2204	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Teth514_2209	COG0285	dihydrofolate synthase activity
Teth514_2211	COG0525	valine-tRNA ligase activity
Teth514_2216	COG0745	RESPONSE REGULATOR receiver
Teth514_2217	COG5002	protein histidine kinase activity
Teth514_2219	COG1691	(AIR) carboxylase
Teth514_2220	COG1606	tRNA processing
Teth514_2221	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Teth514_2224	COG3344	reverse transcriptase
Teth514_2227	COG2814	Major facilitator Superfamily
Teth514_2228	COG0105	UTP biosynthetic process
Teth514_2230	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Teth514_2232	COG3949	Membrane
Teth514_2233	COG1316	TRANSCRIPTIONal
Teth514_2235	COG0489	protein tyrosine kinase activity
Teth514_2236	COG3944	biosynthesis protein
Teth514_2237	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Teth514_2239	COG0250	Participates in transcription elongation, termination and antitermination
Teth514_2240	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
Teth514_2251	COG1914	H( )-stimulated, divalent metal cation uptake system
Teth514_2253	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Teth514_2256	COG4989	oxidoreductase activity
Teth514_2257	COG0622	Phosphoesterase
Teth514_2258	COG1704	LemA family
Teth514_2263	COG2161	toxin-antitoxin pair type II binding
Teth514_2266	COG1401	restriction endodeoxyribonuclease activity
Teth514_2277	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Teth514_2278	COG0438	transferase activity, transferring glycosyl groups
Teth514_2281	COG0438	transferase activity, transferring glycosyl groups
Teth514_2283	COG0438	transferase activity, transferring glycosyl groups
Teth514_2291	COG2239	Acts as a magnesium transporter
Teth514_2293	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Teth514_2294	COG1116	anion transmembrane transporter activity
Teth514_2295	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Teth514_2296	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Teth514_2296	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Teth514_2298	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Teth514_2299	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Teth514_2301	COG0740	serine-type endopeptidase activity
Teth514_2302	COG0544	peptidyl-prolyl cis-trans isomerase activity
Teth514_2304	COG0504	CTP synthase activity
Teth514_2306	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Teth514_2307	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Teth514_2309	COG0083	homoserine kinase activity
Teth514_2310	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Teth514_2311	COG0460	homoserine dehydrogenase
Teth514_2312	COG4492	Belongs to the UPF0735 family
Teth514_2313	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Teth514_2316	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Teth514_2317	COG1518	maintenance of DNA repeat elements
Teth514_2319	COG3340	Belongs to the peptidase S51 family
Teth514_2328	COG0822	iron-sulfur transferase activity
Teth514_2329	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Teth514_2331	COG0719	Fe-S assembly protein
Teth514_2332	COG0396	ATPase activity
Teth514_2333	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Teth514_2338	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Teth514_2342	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Teth514_2343	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Teth514_2345	COG0739	heme binding
Teth514_2347	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Teth514_2348	COG0308	aminopeptidase N
Teth514_2351	COG2333	competence protein COMEC
Teth514_2351	COG0658	competence protein
Teth514_2354	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Teth514_2355	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Teth514_2356	COG0840	transmembrane signaling receptor activity
Teth514_2358	COG0446	pyridine nucleotide-disulphide oxidoreductase
Teth514_2362	COG1394	ATPase activity, coupled to movement of substances
Teth514_2365	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
Teth514_2366	COG1527	subunit (C
Teth514_2368	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Teth514_2369	COG1269	ATP hydrolysis coupled proton transport
Teth514_2387	COG0305	Participates in initiation and elongation during chromosome replication
Teth514_2388	COG0359	binds to the 23S rRNA
Teth514_2392	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Teth514_2393	COG0629	single-stranded DNA binding
Teth514_2394	COG0360	Binds together with S18 to 16S ribosomal RNA
Teth514_2395	COG4481	Protein conserved in bacteria
Teth514_2396	COG0668	transmembrane transport
Teth514_2398	COG0189	ligase activity
Teth514_2398	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Teth514_2400	COG1597	lipid kinase activity
Teth514_2402	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Teth514_2403	COG1475	DNA binding
Teth514_2404	COG1192	Involved in chromosome partitioning
Teth514_2408	COG0445	tRNA wobble uridine modification
Teth514_2410	COG1847	R3H domain protein
Teth514_2411	COG0706	membrane insertase activity
Teth514_2412	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Teth514_2413	COG0594	ribonuclease P activity
Teth514_2414	COG0230	Belongs to the bacterial ribosomal protein bL34 family