locus-tag	class	description
Thewi_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Thewi_0002	COG0592	DNA-directed DNA polymerase activity
Thewi_0003	COG2501	S4 domain
Thewi_0009	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Thewi_0010	COG0187	DNA topoisomerase II activity
Thewi_0011	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Thewi_0012	COG1902	pentaerythritol trinitrate reductase activity
Thewi_0013	COG0440	acetolactate synthase activity
Thewi_0015	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Thewi_0017	COG0066	3-isopropylmalate dehydratase activity
Thewi_0018	COG0473	3-isopropylmalate dehydrogenase activity
Thewi_0019	COG0129	dihydroxy-acid dehydratase activity
Thewi_0020	COG0028	Belongs to the TPP enzyme family
Thewi_0023	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Thewi_0023	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Thewi_0024	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Thewi_0025	COG0628	permease
Thewi_0028	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Thewi_0029	COG1316	TRANSCRIPTIONal
Thewi_0041	COG0651	ATP synthesis coupled electron transport
Thewi_0042	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Thewi_0043	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Thewi_0044	COG0649	NAD binding
Thewi_0044	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Thewi_0045	COG0649	NAD binding
Thewi_0046	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Thewi_0050	COG1966	Carbon starvation protein
Thewi_0051	COG3344	reverse transcriptase
Thewi_0058	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Thewi_0058	COG2199	diguanylate cyclase activity
Thewi_0059	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Thewi_0060	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Thewi_0061	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Thewi_0062	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Thewi_0064	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Thewi_0068	COG1028	Short-chain dehydrogenase reductase Sdr
Thewi_0069	COG1187	pseudouridine synthase activity
Thewi_0070	COG1609	Transcriptional regulator
Thewi_0071	COG1653	transport
Thewi_0073	COG0395	ABC-type sugar transport system, permease component
Thewi_0075	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Thewi_0076	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Thewi_0077	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Thewi_0081	COG1028	Short-chain dehydrogenase reductase Sdr
Thewi_0083	COG1511	domain protein
Thewi_0085	COG0037	tRNA processing
Thewi_0086	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
Thewi_0086	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Thewi_0088	COG1573	uracil-dna glycosylase
Thewi_0091	COG0425	Belongs to the sulfur carrier protein TusA family
Thewi_0092	COG2391	methyltransferase activity
Thewi_0096	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Thewi_0097	COG0509	glycine decarboxylation via glycine cleavage system
Thewi_0099	COG1940	carbohydrate kinase activity
Thewi_0100	COG0519	Catalyzes the synthesis of GMP from XMP
Thewi_0102	COG1982	Orn Lys Arg decarboxylase major
Thewi_0103	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Thewi_0104	COG3870	Protein conserved in bacteria
Thewi_0106	COG0470	DNA polymerase III
Thewi_0107	COG1774	PSP1 C-terminal conserved region
Thewi_0109	COG0730	response to heat
Thewi_0110	COG3464	Transposase
Thewi_0112	COG2235	arginine
Thewi_0113	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Thewi_0114	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Thewi_0115	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Thewi_0116	COG2002	toxin-antitoxin pair type II binding
Thewi_0117	COG2715	membrane protein required for spore maturation
Thewi_0118	COG0700	Nucleoside recognition
Thewi_0119	COG0617	tRNA 3'-terminal CCA addition
Thewi_0121	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Thewi_0121	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Thewi_0122	COG0084	hydrolase, TatD family'
Thewi_0123	COG3584	3D domain protein
Thewi_0123	COG3583	domain protein
Thewi_0124	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Thewi_0129	COG1191	sigma factor activity
Thewi_0130	COG2151	metal-sulfur cluster biosynthetic enzyme
Thewi_0130	COG0489	protein tyrosine kinase activity
Thewi_0133	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Thewi_0134	COG2111	Na H antiporter
Thewi_0134	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Thewi_0135	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Thewi_0136	COG3260	NADH ubiquinone oxidoreductase 20
Thewi_0140	COG0375	protein maturation
Thewi_0142	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Thewi_0143	COG0298	carbon dioxide binding
Thewi_0144	COG0409	Hydrogenase expression formation protein
Thewi_0147	COG0745	RESPONSE REGULATOR receiver
Thewi_0149	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Thewi_0150	COG0254	rRNA binding
Thewi_0151	COG1435	thymidine kinase activity
Thewi_0152	COG3872	metal-dependent enzyme
Thewi_0153	COG2890	protein-(glutamine-N5) methyltransferase activity
Thewi_0156	COG0009	L-threonylcarbamoyladenylate synthase
Thewi_0157	COG0698	ribose 5-phosphate isomerase
Thewi_0158	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Thewi_0160	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Thewi_0161	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Thewi_0164	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Thewi_0167	COG0686	Belongs to the AlaDH PNT family
Thewi_0174	COG2385	sporulation resulting in formation of a cellular spore
Thewi_0176	COG1609	Transcriptional regulator
Thewi_0178	COG4786	Flagellar basal body rod
Thewi_0181	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Thewi_0188	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Thewi_0188	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Thewi_0189	COG2213	PTS system mannitol-specific
Thewi_0189	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thewi_0193	COG1063	alcohol dehydrogenase
Thewi_0196	COG3414	Phosphotransferase system galactitol-specific IIB component
Thewi_0197	COG3775	system Galactitol-specific IIC component
Thewi_0198	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
Thewi_0204	COG4948	Mandelate Racemase Muconate Lactonizing
Thewi_0206	COG0800	Aldolase
Thewi_0207	COG2814	Major facilitator Superfamily
Thewi_0209	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Thewi_0209	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Thewi_0210	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Thewi_0211	COG3715	PTS system
Thewi_0212	COG3716	PTS system mannose fructose sorbose family IID component
Thewi_0213	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thewi_0214	COG0191	fructose-bisphosphate aldolase activity
Thewi_0216	COG2222	sugar isomerase
Thewi_0218	COG0569	domain protein
Thewi_0219	COG1082	Xylose isomerase domain protein TIM barrel
Thewi_0220	COG2115	Belongs to the xylose isomerase family
Thewi_0221	COG1070	Carbohydrate kinase
Thewi_0222	COG1653	transport
Thewi_0224	COG0395	ABC-type sugar transport system, permease component
Thewi_0230	COG1472	Belongs to the glycosyl hydrolase 3 family
Thewi_0234	COG1297	OPT oligopeptide transporter protein
Thewi_0236	COG0436	Aminotransferase
Thewi_0237	COG1522	sequence-specific DNA binding
Thewi_0238	COG3464	Transposase
Thewi_0240	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Thewi_0240	COG1918	ferrous iron import across plasma membrane
Thewi_0243	COG1122	ATPase activity
Thewi_0244	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Thewi_0245	COG0310	cobalt ion transport
Thewi_0246	COG0310	cobalt ion transport
Thewi_0247	COG0864	Transcriptional regulator
Thewi_0248	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
Thewi_0251	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Thewi_0252	COG0534	Mate efflux family protein
Thewi_0253	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Thewi_0254	COG1136	(ABC) transporter
Thewi_0255	COG0577	efflux transmembrane transporter activity
Thewi_0255	COG1136	(ABC) transporter
Thewi_0261	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
Thewi_0262	COG1074	ATP-dependent DNA helicase activity
Thewi_0266	COG0450	alkyl hydroperoxide reductase
Thewi_0269	COG3464	Transposase
Thewi_0272	COG0297	glycogen (starch) synthase activity
Thewi_0273	COG0586	Pfam SNARE associated Golgi protein
Thewi_0277	COG0039	L-malate dehydrogenase activity
Thewi_0282	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Thewi_0283	COG1980	fructose-bisphosphate aldolase activity
Thewi_0285	COG2972	Histidine kinase
Thewi_0286	COG2197	response regulator
Thewi_0287	COG4213	ABC transporter substrate-binding protein
Thewi_0288	COG4213	ABC transporter substrate-binding protein
Thewi_0289	COG1129	ABC transporter
Thewi_0290	COG4214	carbohydrate transport
Thewi_0292	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Thewi_0295	COG0095	Lipoate-protein ligase
Thewi_0296	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Thewi_0298	COG0436	Aminotransferase
Thewi_0299	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thewi_0300	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Thewi_0303	COG3959	Transketolase, thiamine diphosphate binding domain
Thewi_0304	COG3958	Transketolase
Thewi_0306	COG0205	6-phosphofructokinase activity
Thewi_0313	COG3732	PTS system glucitol sorbitol-specific
Thewi_0317	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Thewi_0320	COG2190	(PTS) system
Thewi_0325	COG3464	Transposase
Thewi_0328	COG1979	alcohol dehydrogenase
Thewi_0332	COG0640	Transcriptional regulator
Thewi_0342	COG1309	transcriptional regulator
Thewi_0345	COG1924	4 iron, 4 sulfur cluster binding
Thewi_0346	COG1230	cation diffusion facilitator family transporter
Thewi_0348	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Thewi_0349	COG0390	transport system, permease component
Thewi_0350	COG0495	leucyl-tRNA aminoacylation
Thewi_0351	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
Thewi_0353	COG1522	sequence-specific DNA binding
Thewi_0353	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Thewi_0354	COG2313	pseudouridylate synthase activity
Thewi_0357	COG0306	phosphate transporter
Thewi_0361	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Thewi_0361	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Thewi_0364	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Thewi_0366	COG1486	melibiose metabolic process
Thewi_0369	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Thewi_0370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Thewi_0371	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Thewi_0372	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
Thewi_0373	COG1447	Phosphotransferase system cellobiose-specific component IIA
Thewi_0374	COG0437	4 iron, 4 sulfur cluster binding
Thewi_0375	COG2414	aldehyde ferredoxin oxidoreductase
Thewi_0379	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Thewi_0385	COG0521	Mo-molybdopterin cofactor biosynthetic process
Thewi_0386	COG0303	'Molybdopterin
Thewi_0387	COG1910	domain protein
Thewi_0393	COG2213	PTS system mannitol-specific
Thewi_0394	COG3711	transcriptional antiterminator
Thewi_0394	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thewi_0397	COG0737	Belongs to the 5'-nucleotidase family
Thewi_0398	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Thewi_0399	COG0730	response to heat
Thewi_0404	COG0601	transmembrane transport
Thewi_0405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Thewi_0406	COG0444	Belongs to the ABC transporter superfamily
Thewi_0408	COG3250	beta-galactosidase activity
Thewi_0410	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Thewi_0411	COG1121	(ABC) transporter
Thewi_0412	COG0803	Belongs to the bacterial solute-binding protein 9 family
Thewi_0413	COG0735	belongs to the Fur family
Thewi_0414	COG0714	Associated with various cellular activities
Thewi_0417	COG1704	LemA family
Thewi_0421	COG2221	Nitrite and sulphite reductase 4Fe-4S
Thewi_0422	COG0084	hydrolase, TatD family'
Thewi_0424	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Thewi_0425	COG0822	iron-sulfur transferase activity
Thewi_0428	COG0116	Belongs to the methyltransferase superfamily
Thewi_0429	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Thewi_0430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Thewi_0431	COG1120	ATPase activity
Thewi_0432	COG1797	cobyrinic acid a,c-diamide synthase activity
Thewi_0437	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Thewi_0439	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Thewi_0445	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Thewi_0446	COG0181	hydroxymethylbilane synthase activity
Thewi_0448	COG0113	porphobilinogen synthase activity
Thewi_0449	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Thewi_0449	COG1648	precorrin-2 dehydrogenase activity
Thewi_0452	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Thewi_0458	COG0330	HflC and HflK could
Thewi_0495	COG3344	reverse transcriptase
Thewi_0502	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Thewi_0502	COG2199	diguanylate cyclase activity
Thewi_0505	COG0840	transmembrane signaling receptor activity
Thewi_0506	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Thewi_0508	COG1228	amidohydrolase
Thewi_0514	COG1653	transport
Thewi_0515	COG2972	Histidine kinase
Thewi_0516	COG4753	response regulator
Thewi_0516	COG2207	Transcriptional regulator
Thewi_0517	COG3404	Formiminotransferase-cyclodeaminase
Thewi_0518	COG1744	ABC transporter substrate-binding protein PnrA-like
Thewi_0522	COG2188	Transcriptional regulator
Thewi_0524	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Thewi_0528	COG1263	PTS System
Thewi_0528	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Thewi_0528	COG2190	(PTS) system
Thewi_0529	COG2190	(PTS) system
Thewi_0530	COG3711	transcriptional antiterminator
Thewi_0531	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Thewi_0539	COG2081	HI0933 family
Thewi_0540	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Thewi_0542	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Thewi_0544	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
Thewi_0546	COG2323	membrane
Thewi_0547	COG0561	phosphatase activity
Thewi_0549	COG1609	Transcriptional regulator
Thewi_0550	COG0745	RESPONSE REGULATOR receiver
Thewi_0551	COG5002	protein histidine kinase activity
Thewi_0556	COG1592	Rubrerythrin
Thewi_0557	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Thewi_0558	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Thewi_0559	COG1040	competence protein
Thewi_0563	COG4786	Flagellar basal body rod
Thewi_0563	COG1256	bacterial-type flagellum assembly
Thewi_0564	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Thewi_0566	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
Thewi_0567	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Thewi_0568	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Thewi_0578	COG0463	Glycosyl transferase, family 2
Thewi_0578	COG0457	Tetratricopeptide repeat
Thewi_0579	COG0367	asparagine synthase
Thewi_0582	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Thewi_0585	COG0840	transmembrane signaling receptor activity
Thewi_0587	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Thewi_0588	COG0765	amino acid transport
Thewi_0594	COG1827	regulation of RNA biosynthetic process
Thewi_0596	COG0653	protein targeting
Thewi_0600	COG0398	Pfam SNARE associated Golgi protein
Thewi_0602	COG2235	arginine
Thewi_0603	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Thewi_0604	COG0549	Belongs to the carbamate kinase family
Thewi_0606	COG0802	atpase or kinase
Thewi_0607	COG1214	PFAM Peptidase M22, glycoprotease
Thewi_0609	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Thewi_0612	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Thewi_0615	COG1024	Enoyl-CoA hydratase
Thewi_0616	COG1960	acyl-CoA dehydrogenase activity
Thewi_0617	COG2086	electron transfer activity
Thewi_0618	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Thewi_0620	COG1250	3-hydroxyacyl-CoA dehydrogenase
Thewi_0621	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Thewi_0622	COG0183	Belongs to the thiolase family
Thewi_0624	COG2030	dehydratase
Thewi_0630	COG2267	carboxylic ester hydrolase activity
Thewi_0631	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Thewi_0632	COG0427	acetyl-CoA hydrolase
Thewi_0634	COG0596	Alpha beta hydrolase
Thewi_0636	COG0840	transmembrane signaling receptor activity
Thewi_0637	COG3426	butyrate kinase activity
Thewi_0639	COG3279	Response regulator of the LytR AlgR family
Thewi_0640	COG3290	protein histidine kinase activity
Thewi_0645	COG0493	'glutamate synthase
Thewi_0646	COG0424	maF-like protein
Thewi_0647	COG1811	Na channel or pump
Thewi_0649	COG1404	Belongs to the peptidase S8 family
Thewi_0665	COG3344	reverse transcriptase
Thewi_0666	COG0516	GMP reductase activity
Thewi_0666	COG0517	IMP dehydrogenase activity
Thewi_0667	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Thewi_0667	COG0519	Catalyzes the synthesis of GMP from XMP
Thewi_0668	COG2252	PERMEase
Thewi_0669	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Thewi_0670	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Thewi_0672	COG0047	phosphoribosylformylglycinamidine synthase activity
Thewi_0673	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Thewi_0674	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Thewi_0675	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Thewi_0676	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Thewi_0678	COG0151	Belongs to the GarS family
Thewi_0679	COG2226	methyltransferase
Thewi_0680	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Thewi_0681	COG1473	amidohydrolase
Thewi_0682	COG2244	polysaccharide biosynthetic process
Thewi_0684	COG3711	transcriptional antiterminator
Thewi_0686	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Thewi_0687	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Thewi_0688	COG1447	Phosphotransferase system cellobiose-specific component IIA
Thewi_0689	COG4496	protein, YerC YecD
Thewi_0690	COG0210	DNA helicase
Thewi_0692	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Thewi_0694	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Thewi_0696	COG4166	transmembrane transport
Thewi_0698	COG0601	transmembrane transport
Thewi_0699	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Thewi_0700	COG0444	Belongs to the ABC transporter superfamily
Thewi_0704	COG2247	cell wall binding repeat
Thewi_0704	COG0860	N-Acetylmuramoyl-L-alanine amidase
Thewi_0705	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Thewi_0714	COG0004	ammonium transporteR
Thewi_0715	COG0347	Belongs to the P(II) protein family
Thewi_0716	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Thewi_0717	COG0067	glutamate synthase
Thewi_0718	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Thewi_0718	COG0069	glutamate synthase activity
Thewi_0719	COG0437	4 iron, 4 sulfur cluster binding
Thewi_0724	COG0351	phosphomethylpyrimidine kinase
Thewi_0725	COG0352	thiamine-phosphate diphosphorylase activity
Thewi_0726	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
Thewi_0729	COG0704	Plays a role in the regulation of phosphate uptake
Thewi_0731	COG0686	Belongs to the AlaDH PNT family
Thewi_0732	COG0410	ABC transporter
Thewi_0735	COG0559	Belongs to the binding-protein-dependent transport system permease family
Thewi_0738	COG3464	Transposase
Thewi_0739	COG0544	peptidyl-prolyl cis-trans isomerase activity
Thewi_0740	COG0740	serine-type endopeptidase activity
Thewi_0741	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Thewi_0742	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Thewi_0743	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Thewi_0745	COG0356	it plays a direct role in the translocation of protons across the membrane
Thewi_0746	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Thewi_0747	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Thewi_0748	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Thewi_0749	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Thewi_0750	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Thewi_0751	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Thewi_0752	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Thewi_0754	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Thewi_0754	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Thewi_0756	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Thewi_0757	COG1116	anion transmembrane transporter activity
Thewi_0771	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Thewi_0773	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Thewi_0785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Thewi_0788	COG1091	dTDP-4-dehydrorhamnose reductase activity
Thewi_0806	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Thewi_0806	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Thewi_0828	COG1704	LemA family
Thewi_0829	COG0622	Phosphoesterase
Thewi_0830	COG4989	oxidoreductase activity
Thewi_0837	COG1598	PFAM Uncharacterised protein family UPF0150
Thewi_0846	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Thewi_0847	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Thewi_0848	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
Thewi_0849	COG1607	acyl-coa hydrolase
Thewi_0850	COG3246	L-lysine catabolic process to acetate
Thewi_0851	COG0604	alcohol dehydrogenase
Thewi_0854	COG1193	negative regulation of DNA recombination
Thewi_0855	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Thewi_0856	COG5012	cobalamin binding
Thewi_0857	COG0531	amino acid
Thewi_0858	COG0250	Participates in transcription elongation, termination and antitermination
Thewi_0860	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Thewi_0861	COG3944	biosynthesis protein
Thewi_0862	COG0489	protein tyrosine kinase activity
Thewi_0864	COG1316	TRANSCRIPTIONal
Thewi_0867	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Thewi_0868	COG0105	UTP biosynthetic process
Thewi_0869	COG2814	Major facilitator Superfamily
Thewi_0872	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Thewi_0873	COG0671	phosphoesterase, PA-phosphatase related
Thewi_0876	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Thewi_0877	COG0840	transmembrane signaling receptor activity
Thewi_0879	COG1691	(AIR) carboxylase
Thewi_0882	COG0745	RESPONSE REGULATOR receiver
Thewi_0887	COG0525	valine-tRNA ligase activity
Thewi_0889	COG0285	dihydrofolate synthase activity
Thewi_0895	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Thewi_0896	COG1609	Transcriptional regulator
Thewi_0898	COG1653	transport
Thewi_0899	COG1175	transmembrane transport
Thewi_0900	COG0395	ABC-type sugar transport system, permease component
Thewi_0901	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Thewi_0905	COG0395	ABC-type sugar transport system, permease component
Thewi_0908	COG1404	Belongs to the peptidase S8 family
Thewi_0909	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Thewi_0909	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Thewi_0910	COG3773	Cell wall hydrolase
Thewi_0910	COG3409	Peptidoglycan-binding domain 1 protein
Thewi_0913	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Thewi_0915	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Thewi_0916	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Thewi_0917	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Thewi_0919	COG1132	(ABC) transporter
Thewi_0920	COG1132	(ABC) transporter
Thewi_0924	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Thewi_0928	COG0739	heme binding
Thewi_0932	COG2986	histidine ammonia-lyase
Thewi_0935	COG1131	(ABC) transporter
Thewi_0937	COG0616	signal peptide processing
Thewi_0942	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Thewi_0943	COG4475	Protein of unknown function (DUF436)
Thewi_0951	COG1983	PspC domain protein
Thewi_0952	COG0726	polysaccharide deacetylase
Thewi_0956	COG1966	Carbon starvation protein
Thewi_0957	COG3279	Response regulator of the LytR AlgR family
Thewi_0958	COG3275	phosphorelay sensor kinase activity
Thewi_0959	COG1595	DNA-templated transcription, initiation
Thewi_0962	COG0237	dephospho-CoA kinase activity
Thewi_0963	COG0741	lytic transglycosylase activity
Thewi_0966	COG0791	NLP P60 protein
Thewi_0969	COG0741	lytic transglycosylase activity
Thewi_0973	COG2878	Part of a membrane complex involved in electron transport
Thewi_0977	COG4191	Histidine kinase
Thewi_0977	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Thewi_0982	COG0424	maF-like protein
Thewi_0983	COG2003	Belongs to the UPF0758 family
Thewi_0984	COG1077	Cell shape determining protein MreB Mrl
Thewi_0988	COG0850	regulation of cytokinetic process
Thewi_0989	COG2894	cell division
Thewi_0990	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Thewi_0991	COG0772	Belongs to the SEDS family
Thewi_0992	COG1803	Methylglyoxal synthase
Thewi_0993	COG0739	heme binding
Thewi_0994	COG0517	IMP dehydrogenase activity
Thewi_0994	COG1994	Peptidase M50
Thewi_0997	COG1530	ribonuclease E activity
Thewi_0998	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Thewi_0999	COG4708	membrane
Thewi_1002	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Thewi_1004	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Thewi_1007	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Thewi_1008	COG1713	HD superfamily hydrolase involved in NAD metabolism
Thewi_1009	COG1316	TRANSCRIPTIONal
Thewi_1014	COG0367	asparagine synthase
Thewi_1015	COG1686	Belongs to the peptidase S11 family
Thewi_1016	COG1555	photosystem II stabilization
Thewi_1016	COG1596	polysaccharide export
Thewi_1018	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Thewi_1022	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Thewi_1026	COG4720	Psort location CytoplasmicMembrane, score
Thewi_1029	COG1234	tRNA 3'-trailer cleavage
Thewi_1030	COG0658	competence protein
Thewi_1030	COG2333	competence protein COMEC
Thewi_1032	COG0268	Binds directly to 16S ribosomal RNA
Thewi_1034	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Thewi_1040	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Thewi_1041	COG1420	regulation of RNA biosynthetic process
Thewi_1042	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Thewi_1043	COG0443	Heat shock 70 kDa protein
Thewi_1044	COG0484	heat shock protein binding
Thewi_1045	COG2264	protein methyltransferase activity
Thewi_1047	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Thewi_1048	COG0537	adenosine 5'-monophosphoramidase activity
Thewi_1049	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Thewi_1054	COG1702	phosphate starvation-inducible protein PhoH
Thewi_1055	COG1480	7TM receptor with intracellular HD hydrolase
Thewi_1056	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Thewi_1057	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Thewi_1059	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Thewi_1063	COG0423	glycine-tRNA ligase activity
Thewi_1064	COG0517	IMP dehydrogenase activity
Thewi_1065	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Thewi_1066	COG0574	Belongs to the PEP-utilizing enzyme family
Thewi_1066	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Thewi_1068	COG0557	exoribonuclease II activity
Thewi_1072	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
Thewi_1075	COG0693	protein deglycase activity
Thewi_1078	COG2267	carboxylic ester hydrolase activity
Thewi_1086	COG0584	glycerophosphoryl diester phosphodiesterase
Thewi_1088	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Thewi_1089	COG1968	undecaprenyl-diphosphatase activity
Thewi_1093	COG3069	C4-dicarboxylate transmembrane transporter activity
Thewi_1095	COG0426	domain, Protein
Thewi_1096	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Thewi_1098	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Thewi_1099	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Thewi_1100	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Thewi_1103	COG1760	l-serine dehydratase
Thewi_1104	COG1164	Oligoendopeptidase f
Thewi_1105	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Thewi_1106	COG1605	Chorismate mutase
Thewi_1106	COG0077	Prephenate dehydratase
Thewi_1107	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Thewi_1108	COG0287	Prephenate dehydrogenase
Thewi_1109	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Thewi_1110	COG0745	RESPONSE REGULATOR receiver
Thewi_1111	COG3850	Histidine kinase
Thewi_1111	COG5002	protein histidine kinase activity
Thewi_1113	COG3773	Cell wall hydrolase
Thewi_1113	COG3409	Peptidoglycan-binding domain 1 protein
Thewi_1114	COG2119	membrane
Thewi_1117	COG0745	RESPONSE REGULATOR receiver
Thewi_1118	COG2205	protein histidine kinase activity
Thewi_1124	COG0363	glucosamine-6-phosphate deaminase activity
Thewi_1127	COG1136	(ABC) transporter
Thewi_1129	COG0785	Cytochrome C biogenesis protein
Thewi_1130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Thewi_1131	COG3118	belongs to the thioredoxin family
Thewi_1132	COG1982	Orn Lys Arg decarboxylase major
Thewi_1142	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Thewi_1145	COG1739	Uncharacterized protein family UPF0029
Thewi_1150	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Thewi_1151	COG0217	transcriptional regulatory protein
Thewi_1152	COG0835	chemotaxis
Thewi_1154	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Thewi_1155	COG0632	four-way junction helicase activity
Thewi_1156	COG2255	four-way junction helicase activity
Thewi_1158	COG2385	sporulation resulting in formation of a cellular spore
Thewi_1158	COG2247	cell wall binding repeat
Thewi_1160	COG0343	queuine tRNA-ribosyltransferase activity
Thewi_1165	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Thewi_1166	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Thewi_1167	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Thewi_1169	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Thewi_1169	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Thewi_1170	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Thewi_1171	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Thewi_1173	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Thewi_1174	COG0577	efflux transmembrane transporter activity
Thewi_1175	COG1136	(ABC) transporter
Thewi_1177	COG1846	Transcriptional regulator
Thewi_1179	COG0124	histidyl-tRNA synthetase
Thewi_1180	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Thewi_1181	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Thewi_1182	COG1937	Protein conserved in bacteria
Thewi_1183	COG3118	belongs to the thioredoxin family
Thewi_1184	COG3804	dihydrodipicolinate reductase
Thewi_1186	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Thewi_1188	COG5012	cobalamin binding
Thewi_1192	COG1959	2 iron, 2 sulfur cluster binding
Thewi_1195	COG0628	permease
Thewi_1196	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Thewi_1197	COG4472	Bacterial protein of unknown function (DUF965)
Thewi_1198	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Thewi_1199	COG3906	Belongs to the UPF0473 family
Thewi_1200	COG0735	belongs to the Fur family
Thewi_1201	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Thewi_1202	COG3679	Belongs to the UPF0342 family
Thewi_1203	COG4708	membrane
Thewi_1204	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Thewi_1207	COG0768	penicillin binding
Thewi_1208	COG1191	sigma factor activity
Thewi_1210	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Thewi_1214	COG4968	Prepilin-type N-terminal cleavage methylation domain
Thewi_1215	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Thewi_1224	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Thewi_1226	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Thewi_1227	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Thewi_1228	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Thewi_1229	COG0006	proline dipeptidase activity
Thewi_1230	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Thewi_1232	COG3854	ATPases associated with a variety of cellular activities
Thewi_1240	COG1302	Protein conserved in bacteria
Thewi_1241	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Thewi_1242	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Thewi_1243	COG1570	exodeoxyribonuclease VII activity
Thewi_1244	COG1722	exodeoxyribonuclease VII activity
Thewi_1245	COG0142	geranyltranstransferase activity
Thewi_1247	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Thewi_1248	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Thewi_1249	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Thewi_1250	COG1438	arginine binding
Thewi_1251	COG0497	DNA recombination
Thewi_1252	COG0750	zinc metalloprotease
Thewi_1261	COG1379	DNA repair
Thewi_1262	COG1300	Membrane
Thewi_1264	COG1686	Belongs to the peptidase S11 family
Thewi_1265	COG1366	Belongs to the anti-sigma-factor antagonist family
Thewi_1266	COG2172	sigma factor antagonist activity
Thewi_1268	COG3360	Dodecin
Thewi_1272	COG0617	tRNA 3'-terminal CCA addition
Thewi_1273	COG1994	Peptidase M50
Thewi_1274	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Thewi_1275	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Thewi_1280	COG3874	Sporulation protein YtfJ
Thewi_1282	COG1686	Belongs to the peptidase S11 family
Thewi_1285	COG0445	tRNA wobble uridine modification
Thewi_1286	COG1187	pseudouridine synthase activity
Thewi_1288	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Thewi_1289	COG0010	Belongs to the arginase family
Thewi_1291	COG1705	Flagellar rod assembly protein muramidase FlgJ
Thewi_1291	COG1388	LysM domain
Thewi_1293	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Thewi_1295	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Thewi_1295	COG0674	pyruvate-flavodoxin oxidoreductase activity
Thewi_1296	COG1013	pyruvate-flavodoxin oxidoreductase activity
Thewi_1301	COG0406	alpha-ribazole phosphatase activity
Thewi_1302	COG2081	HI0933 family
Thewi_1305	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Thewi_1307	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Thewi_1308	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Thewi_1308	COG0539	negative regulation of cytoplasmic translation
Thewi_1310	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Thewi_1311	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Thewi_1312	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Thewi_1313	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Thewi_1315	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Thewi_1316	COG1923	regulation of RNA biosynthetic process
Thewi_1317	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Thewi_1318	COG0328	RNA-DNA hybrid ribonuclease activity
Thewi_1319	COG4974	Belongs to the 'phage' integrase family
Thewi_1320	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
Thewi_1321	COG0464	growth
Thewi_1324	COG0613	PHP domain protein
Thewi_1325	COG2359	stage V sporulation protein S
Thewi_1326	COG1692	metallophosphoesterase
Thewi_1330	COG2137	regulation of response to DNA damage stimulus
Thewi_1331	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Thewi_1332	COG1546	Belongs to the CinA family
Thewi_1332	COG1058	Belongs to the CinA family
Thewi_1333	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Thewi_1334	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Thewi_1337	COG0740	serine-type endopeptidase activity
Thewi_1338	COG0527	aspartate kinase activity
Thewi_1340	COG0756	dUTP diphosphatase activity
Thewi_1341	COG0612	Peptidase, M16
Thewi_1343	COG1185	polyribonucleotide nucleotidyltransferase activity
Thewi_1344	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Thewi_1346	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Thewi_1347	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Thewi_1348	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Thewi_1351	COG2740	Nucleic-acid-binding protein implicated in transcription termination
Thewi_1352	COG0195	Participates in both transcription termination and antitermination
Thewi_1353	COG0779	Required for maturation of 30S ribosomal subunits
Thewi_1354	COG2176	DNA-directed DNA polymerase activity
Thewi_1356	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Thewi_1357	COG0750	zinc metalloprotease
Thewi_1358	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Thewi_1359	COG4589	Belongs to the CDS family
Thewi_1360	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Thewi_1362	COG0233	cytoplasmic translational termination
Thewi_1363	COG0528	UMP kinase activity
Thewi_1364	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Thewi_1368	COG1191	sigma factor activity
Thewi_1369	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Thewi_1370	COG1776	CheC inhibitor of MCP methylation
Thewi_1371	COG0835	chemotaxis
Thewi_1372	COG2198	Histidine kinase
Thewi_1372	COG0643	Histidine kinase
Thewi_1373	COG2201	protein-glutamate methylesterase activity
Thewi_1375	COG0455	bacterial-type flagellum organization
Thewi_1376	COG1419	protein localization to endoplasmic reticulum
Thewi_1377	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Thewi_1378	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Thewi_1379	COG1684	flagellar biosynthetic protein fliR
Thewi_1380	COG1987	bacterial-type flagellum assembly
Thewi_1381	COG1338	Plays a role in the flagellum-specific transport system
Thewi_1383	COG2201	protein-glutamate methylesterase activity
Thewi_1384	COG1776	CheC inhibitor of MCP methylation
Thewi_1384	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Thewi_1385	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Thewi_1387	COG1582	Flagellar protein (FlbD)
Thewi_1390	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Thewi_1394	COG1157	protein secretion by the type III secretion system
Thewi_1396	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Thewi_1398	COG1677	Flagellar hook-basal body complex protein FliE
Thewi_1400	COG1815	bacterial-type flagellum-dependent cell motility
Thewi_1401	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
Thewi_1403	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Thewi_1404	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Thewi_1405	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Thewi_1405	COG0758	DNA mediated transformation
Thewi_1406	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Thewi_1407	COG0792	nuclease activity
Thewi_1408	COG0180	Tryptophanyl-tRNA synthetase
Thewi_1409	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Thewi_1410	COG0606	chelatase, subunit chli
Thewi_1412	COG0335	large ribosomal subunit rRNA binding
Thewi_1413	COG0336	Belongs to the RNA methyltransferase TrmD family
Thewi_1414	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Thewi_1415	COG1837	Belongs to the UPF0109 family
Thewi_1416	COG0228	four-way junction DNA binding
Thewi_1417	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Thewi_1418	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
Thewi_1419	COG0552	protein localization to endoplasmic reticulum
Thewi_1422	COG2359	stage V sporulation protein S
Thewi_1424	COG0571	ribonuclease III activity
Thewi_1425	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Thewi_1426	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Thewi_1427	COG1028	Short-chain dehydrogenase reductase Sdr
Thewi_1428	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Thewi_1429	COG2070	2-Nitropropane dioxygenase
Thewi_1430	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Thewi_1431	COG0416	fatty acid biosynthetic process
Thewi_1432	COG2030	dehydratase
Thewi_1433	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Thewi_1434	COG1399	metal-binding, possibly nucleic acid-binding protein
Thewi_1435	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Thewi_1436	COG0280	phosphate acetyltransferase
Thewi_1438	COG3314	Sporulation integral membrane protein YlbJ
Thewi_1440	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Thewi_1441	COG0742	ribosomal rna small subunit methyltransferase
Thewi_1444	COG1307	EDD domain protein, DegV family
Thewi_1445	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Thewi_1446	COG1461	Dihydroxyacetone kinase
Thewi_1447	COG1302	Protein conserved in bacteria
Thewi_1452	COG1162	GTPase activity
Thewi_1453	COG2815	serine threonine protein kinase
Thewi_1453	COG0515	serine threonine protein kinase
Thewi_1454	COG0631	protein serine/threonine phosphatase activity
Thewi_1455	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Thewi_1456	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Thewi_1456	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Thewi_1457	COG2738	Putative neutral zinc metallopeptidase
Thewi_1459	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Thewi_1460	COG0242	peptide deformylase activity
Thewi_1461	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Thewi_1462	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Thewi_1464	COG0194	GDP metabolic process
Thewi_1465	COG2052	Domain of unknown function (DUF370)
Thewi_1466	COG1561	YicC-like family, N-terminal region
Thewi_1467	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Thewi_1468	COG2814	Major facilitator Superfamily
Thewi_1473	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Thewi_1474	COG2011	ABC-type metal ion transport system permease component
Thewi_1476	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Thewi_1477	COG0037	tRNA processing
Thewi_1480	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Thewi_1482	COG0543	2 iron, 2 sulfur cluster binding
Thewi_1484	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Thewi_1485	COG0540	Belongs to the ATCase OTCase family
Thewi_1486	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Thewi_1487	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Thewi_1488	COG0564	pseudouridine synthase activity
Thewi_1489	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Thewi_1501	COG1970	mechanosensitive ion channel activity
Thewi_1503	COG0778	Nitroreductase
Thewi_1504	COG1595	DNA-templated transcription, initiation
Thewi_1507	COG1983	PspC domain protein
Thewi_1511	COG0626	cystathionine gamma-synthase activity
Thewi_1516	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Thewi_1517	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Thewi_1521	COG0134	indole-3-glycerol-phosphate synthase activity
Thewi_1522	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Thewi_1523	COG0512	Glutamine amidotransferase of anthranilate synthase
Thewi_1523	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Thewi_1527	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Thewi_1528	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Thewi_1529	COG0235	Class ii aldolase
Thewi_1530	COG0402	S-adenosylhomocysteine deaminase activity
Thewi_1531	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Thewi_1533	COG3599	regulation of cell shape
Thewi_1534	COG2302	S4 RNA-binding domain
Thewi_1536	COG1799	cell septum assembly
Thewi_1537	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Thewi_1543	COG4948	Mandelate Racemase Muconate Lactonizing
Thewi_1547	COG2610	gluconate transmembrane transporter activity
Thewi_1548	COG1929	Belongs to the glycerate kinase type-1 family
Thewi_1552	COG0489	protein tyrosine kinase activity
Thewi_1552	COG2151	metal-sulfur cluster biosynthetic enzyme
Thewi_1557	COG0640	Transcriptional regulator
Thewi_1560	COG2814	Major facilitator Superfamily
Thewi_1562	COG1131	(ABC) transporter
Thewi_1564	COG0653	protein targeting
Thewi_1565	COG0531	amino acid
Thewi_1571	COG0745	RESPONSE REGULATOR receiver
Thewi_1576	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Thewi_1577	COG1160	GTP binding
Thewi_1585	COG0704	Plays a role in the regulation of phosphate uptake
Thewi_1586	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Thewi_1587	COG0581	inorganic phosphate transmembrane transporter activity
Thewi_1588	COG0573	inorganic phosphate transmembrane transporter activity
Thewi_1589	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Thewi_1591	COG0745	RESPONSE REGULATOR receiver
Thewi_1592	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Thewi_1594	COG1873	PFAM PRC-barrel domain
Thewi_1595	COG1191	sigma factor activity
Thewi_1596	COG1191	sigma factor activity
Thewi_1598	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Thewi_1599	COG0849	cell division
Thewi_1600	COG3856	small basic protein
Thewi_1603	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Thewi_1604	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Thewi_1605	COG0772	Belongs to the SEDS family
Thewi_1606	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Thewi_1607	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Thewi_1608	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Thewi_1609	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Thewi_1610	COG0768	penicillin binding
Thewi_1614	COG0612	Peptidase, M16
Thewi_1615	COG0612	Peptidase, M16
Thewi_1621	COG0301	tRNA thio-modification
Thewi_1624	COG3344	reverse transcriptase
Thewi_1627	COG0508	dehydrogenase complex catalyzes the overall conversion of
Thewi_1628	COG3199	ATP-NAD kinase
Thewi_1629	COG0022	dehydrogenase e1 component
Thewi_1630	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Thewi_1631	COG0459	protein refolding
Thewi_1634	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Thewi_1635	COG0321	lipoyl(octanoyl) transferase activity
Thewi_1640	COG2340	Cysteine-rich secretory protein family
Thewi_1641	COG1362	aminopeptidase activity
Thewi_1642	COG2197	response regulator
Thewi_1645	COG1683	Conserved Protein
Thewi_1646	COG1193	negative regulation of DNA recombination
Thewi_1647	COG0826	peptidase U32
Thewi_1649	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Thewi_1649	COG0072	phenylalanine-tRNA ligase activity
Thewi_1650	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Thewi_1653	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Thewi_1654	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Thewi_1655	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Thewi_1657	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Thewi_1659	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Thewi_1660	COG4399	Belongs to the UPF0754 family
Thewi_1663	COG0745	RESPONSE REGULATOR receiver
Thewi_1664	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Thewi_1665	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Thewi_1666	COG1278	Cold shock
Thewi_1667	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Thewi_1670	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Thewi_1671	COG1956	GAF domain-containing protein
Thewi_1672	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Thewi_1675	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Thewi_1677	COG1482	cell wall glycoprotein biosynthetic process
Thewi_1678	COG0813	purine-nucleoside phosphorylase activity
Thewi_1679	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Thewi_1680	COG2384	SAM-dependent methyltransferase
Thewi_1681	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Thewi_1682	COG0358	DNA primase activity
Thewi_1683	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Thewi_1684	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Thewi_1685	COG0148	phosphopyruvate hydratase activity
Thewi_1687	COG0149	triose-phosphate isomerase activity
Thewi_1688	COG0126	phosphoglycerate kinase activity
Thewi_1690	COG2390	Transcriptional regulator
Thewi_1691	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Thewi_1692	COG1254	Belongs to the acylphosphatase family
Thewi_1693	COG0561	phosphatase activity
Thewi_1696	COG2720	vancomycin resistance protein
Thewi_1697	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Thewi_1698	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Thewi_1699	COG1067	ATP-dependent peptidase activity
Thewi_1704	COG0840	transmembrane signaling receptor activity
Thewi_1705	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Thewi_1711	COG3464	Transposase
Thewi_1720	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Thewi_1723	COG2721	sulfolactate sulfo-lyase activity
Thewi_1726	COG1070	Carbohydrate kinase
Thewi_1729	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Thewi_1731	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Thewi_1732	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Thewi_1734	COG0613	PHP domain protein
Thewi_1735	COG0546	phosphoglycolate phosphatase activity
Thewi_1736	COG0698	ribose 5-phosphate isomerase
Thewi_1737	COG3958	Transketolase
Thewi_1738	COG3959	Transketolase, thiamine diphosphate binding domain
Thewi_1739	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Thewi_1742	COG0564	pseudouridine synthase activity
Thewi_1745	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Thewi_1749	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Thewi_1750	COG0463	Glycosyl transferase, family 2
Thewi_1757	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Thewi_1760	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
Thewi_1763	COG3546	catalase activity
Thewi_1764	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Thewi_1765	COG1410	methionine synthase
Thewi_1765	COG0646	methionine synthase
Thewi_1766	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Thewi_1766	COG0646	methionine synthase
Thewi_1767	COG0058	SHG alpha-glucan phosphorylase activity
Thewi_1768	COG0166	Belongs to the GPI family
Thewi_1770	COG0778	Nitroreductase
Thewi_1771	COG2195	Cleaves the N-terminal amino acid of tripeptides
Thewi_1774	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Thewi_1776	COG1174	glycine betaine transport
Thewi_1777	COG1125	glycine betaine transport
Thewi_1777	COG0517	IMP dehydrogenase activity
Thewi_1778	COG0471	metal ion transport
Thewi_1778	COG3273	potassium ion transport
Thewi_1779	COG0534	Mate efflux family protein
Thewi_1783	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Thewi_1787	COG0205	6-phosphofructokinase activity
Thewi_1790	COG4109	DRTGG domain
Thewi_1791	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thewi_1792	COG1481	regulation of sporulation
Thewi_1794	COG0366	Alpha amylase catalytic
Thewi_1795	COG1426	Protein conserved in bacteria
Thewi_1798	COG3833	ABC-type maltose transport systems, permease component
Thewi_1799	COG1175	transmembrane transport
Thewi_1800	COG2182	Extracellular solute-binding protein
Thewi_1805	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Thewi_1807	COG1752	Esterase of the alpha-beta hydrolase superfamily
Thewi_1808	COG1309	transcriptional regulator
Thewi_1809	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Thewi_1814	COG2217	Heavy metal translocating P-type atpase
Thewi_1815	COG0482	sulfurtransferase activity
Thewi_1817	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Thewi_1820	COG2608	mercury ion transmembrane transporter activity
Thewi_1821	COG0586	Pfam SNARE associated Golgi protein
Thewi_1822	COG1342	Belongs to the UPF0251 family
Thewi_1823	COG5001	Diguanylate cyclase
Thewi_1823	COG5002	protein histidine kinase activity
Thewi_1823	COG3447	MASE1 domain protein
Thewi_1831	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Thewi_1831	COG1918	ferrous iron import across plasma membrane
Thewi_1836	COG1120	ATPase activity
Thewi_1837	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Thewi_1840	COG0446	pyridine nucleotide-disulphide oxidoreductase
Thewi_1841	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Thewi_1844	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Thewi_1846	COG0489	protein tyrosine kinase activity
Thewi_1847	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Thewi_1851	COG2226	methyltransferase
Thewi_1856	COG1609	Transcriptional regulator
Thewi_1857	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Thewi_1861	COG2182	Extracellular solute-binding protein
Thewi_1872	COG0483	inositol monophosphate 1-phosphatase activity
Thewi_1878	COG1070	Carbohydrate kinase
Thewi_1879	COG0434	BtpA family
Thewi_1880	COG1349	DNA-binding transcription factor activity
Thewi_1882	COG0653	protein targeting
Thewi_1887	COG0842	Transport permease protein
Thewi_1887	COG1129	ABC transporter
Thewi_1888	COG1131	(ABC) transporter
Thewi_1892	COG3250	beta-galactosidase activity
Thewi_1898	COG1940	carbohydrate kinase activity
Thewi_1899	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Thewi_1900	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Thewi_1901	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
Thewi_1903	COG0800	Aldolase
Thewi_1904	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Thewi_1906	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Thewi_1907	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thewi_1907	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Thewi_1908	COG3716	PTS system mannose fructose sorbose family IID component
Thewi_1910	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Thewi_1910	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thewi_1912	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Thewi_1912	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Thewi_1913	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Thewi_1915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Thewi_1917	COG1349	DNA-binding transcription factor activity
Thewi_1918	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Thewi_1923	COG0673	inositol 2-dehydrogenase activity
Thewi_1924	COG0673	inositol 2-dehydrogenase activity
Thewi_1931	COG3885	ferrous iron binding
Thewi_1931	COG2078	PFAM AMMECR1 domain protein
Thewi_1933	COG0318	PFAM AMP-dependent synthetase and ligase
Thewi_1934	COG1940	carbohydrate kinase activity
Thewi_1936	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Thewi_1939	COG0768	penicillin binding
Thewi_1943	COG0556	nucleotide-excision repair
Thewi_1944	COG2045	Belongs to the ComB family
Thewi_1945	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Thewi_1946	COG0793	Belongs to the peptidase S41A family
Thewi_1946	COG3409	Peptidoglycan-binding domain 1 protein
Thewi_1947	COG0739	heme binding
Thewi_1948	COG2177	Part of the ABC transporter FtsEX involved in
Thewi_1949	COG2884	Cell division ATP-binding protein ftsE
Thewi_1950	COG3835	regulator
Thewi_1951	COG3842	ATPase activity
Thewi_1955	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Thewi_1956	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Thewi_1959	COG2161	toxin-antitoxin pair type II binding
Thewi_1966	COG3464	Transposase
Thewi_1978	COG0493	'glutamate synthase
Thewi_1978	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Thewi_1986	COG3464	Transposase
Thewi_1990	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Thewi_1992	COG0849	cell division
Thewi_1993	COG4166	transmembrane transport
Thewi_2000	COG0443	Heat shock 70 kDa protein
Thewi_2001	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Thewi_2002	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thewi_2002	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Thewi_2002	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
Thewi_2004	COG2376	Dihydroxyacetone kinase
Thewi_2007	COG0446	pyridine nucleotide-disulphide oxidoreductase
Thewi_2010	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Thewi_2011	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
Thewi_2016	COG2205	protein histidine kinase activity
Thewi_2017	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
Thewi_2018	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
Thewi_2019	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Thewi_2021	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Thewi_2023	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
Thewi_2024	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Thewi_2026	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Thewi_2027	COG0140	phosphoribosyl-ATP diphosphatase activity
Thewi_2027	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Thewi_2030	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Thewi_2031	COG0131	Imidazoleglycerol-phosphate dehydratase
Thewi_2032	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Thewi_2033	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Thewi_2042	COG1131	(ABC) transporter
Thewi_2043	COG3459	Glycosyltransferase 36 associated
Thewi_2044	COG0598	Magnesium transport protein CorA
Thewi_2047	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
Thewi_2047	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Thewi_2048	COG0673	inositol 2-dehydrogenase activity
Thewi_2049	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Thewi_2051	COG0460	homoserine dehydrogenase
Thewi_2056	COG1773	rubredoxin
Thewi_2057	COG2205	protein histidine kinase activity
Thewi_2058	COG1757	Na H antiporter
Thewi_2059	COG0205	6-phosphofructokinase activity
Thewi_2061	COG3958	Transketolase
Thewi_2062	COG3959	Transketolase, thiamine diphosphate binding domain
Thewi_2063	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Thewi_2069	COG2337	Toxic component of a toxin-antitoxin (TA) module
Thewi_2071	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Thewi_2073	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Thewi_2073	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Thewi_2074	COG0736	holo-[acyl-carrier-protein] synthase activity
Thewi_2085	COG1131	(ABC) transporter
Thewi_2088	COG0450	alkyl hydroperoxide reductase
Thewi_2095	COG0191	fructose-bisphosphate aldolase activity
Thewi_2096	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Thewi_2097	COG1172	Belongs to the binding-protein-dependent transport system permease family
Thewi_2099	COG1879	ABC-type sugar transport system periplasmic component
Thewi_2113	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Thewi_2114	COG5012	cobalamin binding
Thewi_2120	COG3716	PTS system mannose fructose sorbose family IID component
Thewi_2121	COG3715	PTS system
Thewi_2122	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Thewi_2123	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Thewi_2123	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Thewi_2130	COG3716	PTS system mannose fructose sorbose family IID component
Thewi_2131	COG3715	PTS system
Thewi_2132	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Thewi_2138	COG2333	competence protein COMEC
Thewi_2138	COG0658	competence protein
Thewi_2143	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
Thewi_2144	COG1793	dna ligase
Thewi_2145	COG0432	Pfam Uncharacterised protein family UPF0047
Thewi_2155	COG1396	sequence-specific DNA binding
Thewi_2156	COG4974	Belongs to the 'phage' integrase family
Thewi_2159	COG0358	DNA primase activity
Thewi_2168	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Thewi_2175	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Thewi_2177	COG0204	Acyl-transferase
Thewi_2177	COG0318	PFAM AMP-dependent synthetase and ligase
Thewi_2180	COG0280	phosphate acetyltransferase
Thewi_2186	COG3426	butyrate kinase activity
Thewi_2187	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Thewi_2188	COG0280	phosphate acetyltransferase
Thewi_2189	COG3426	butyrate kinase activity
Thewi_2191	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
Thewi_2198	COG0714	Associated with various cellular activities
Thewi_2199	COG0546	phosphoglycolate phosphatase activity
Thewi_2201	COG1388	LysM domain
Thewi_2201	COG1705	Flagellar rod assembly protein muramidase FlgJ
Thewi_2207	COG0708	Exodeoxyribonuclease III
Thewi_2208	COG2033	superoxide reductase activity
Thewi_2209	COG2198	Histidine kinase
Thewi_2209	COG0643	Histidine kinase
Thewi_2210	COG0643	Histidine kinase
Thewi_2210	COG2198	Histidine kinase
Thewi_2212	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Thewi_2214	COG2201	protein-glutamate methylesterase activity
Thewi_2215	COG0835	chemotaxis
Thewi_2218	COG2508	Transcriptional regulator
Thewi_2218	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
Thewi_2220	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Thewi_2221	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Thewi_2222	COG0101	tRNA pseudouridine synthase activity
Thewi_2223	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Thewi_2224	COG1122	ATPase activity
Thewi_2225	COG1122	ATPase activity
Thewi_2226	COG0203	ribosomal protein L17
Thewi_2227	COG0202	RNA polymerase activity
Thewi_2228	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Thewi_2229	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Thewi_2230	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Thewi_2232	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Thewi_2235	COG0563	adenylate kinase activity
Thewi_2236	COG0201	protein transport
Thewi_2237	COG0200	Binds to the 23S rRNA
Thewi_2238	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Thewi_2239	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Thewi_2240	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Thewi_2241	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Thewi_2242	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Thewi_2243	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Thewi_2244	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Thewi_2245	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Thewi_2246	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Thewi_2247	COG0255	Belongs to the universal ribosomal protein uL29 family
Thewi_2249	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Thewi_2250	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Thewi_2251	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Thewi_2252	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Thewi_2253	COG0089	rRNA binding
Thewi_2254	COG0088	Forms part of the polypeptide exit tunnel
Thewi_2255	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Thewi_2256	COG0051	transcription antitermination factor activity, RNA binding
Thewi_2257	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Thewi_2258	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Thewi_2259	COG0049	tRNA binding
Thewi_2260	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Thewi_2261	COG1358	cellular component organization or biogenesis
Thewi_2262	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Thewi_2263	COG0085	RNA polymerase activity
Thewi_2264	COG0222	ribosome binding
Thewi_2266	COG0081	regulation of translation
Thewi_2267	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Thewi_2268	COG0250	Participates in transcription elongation, termination and antitermination
Thewi_2269	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Thewi_2270	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Thewi_2271	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Thewi_2272	COG1595	DNA-templated transcription, initiation
Thewi_2273	COG3688	RNA-binding protein containing a PIN domain
Thewi_2274	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Thewi_2276	COG0215	cysteine-tRNA ligase activity
Thewi_2277	COG1045	serine acetyltransferase
Thewi_2280	COG0442	prolyl-tRNA aminoacylation
Thewi_2281	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Thewi_2283	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Thewi_2284	COG4956	integral membrane protein (PIN domain superfamily)
Thewi_2286	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Thewi_2287	COG1914	H( )-stimulated, divalent metal cation uptake system
Thewi_2289	COG0542	response to heat
Thewi_2290	COG3869	Catalyzes the specific phosphorylation of arginine residues in
Thewi_2291	COG3880	PFAM UvrB UvrC protein
Thewi_2294	COG0281	malic enzyme
Thewi_2295	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Thewi_2296	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Thewi_2297	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thewi_2298	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thewi_2298	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thewi_2298	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thewi_2299	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thewi_2299	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thewi_2299	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thewi_2300	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thewi_2300	COG3711	transcriptional antiterminator
Thewi_2301	COG0745	RESPONSE REGULATOR receiver
Thewi_2301	COG3706	GGDEF domain
Thewi_2305	COG4224	UPF0291 protein
Thewi_2307	COG0823	Involved in the tonB-independent uptake of proteins
Thewi_2307	COG1506	peptidase
Thewi_2307	COG4946	Tricorn protease homolog
Thewi_2309	COG0720	synthase
Thewi_2310	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Thewi_2311	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Thewi_2312	COG0302	gtp cyclohydrolase
Thewi_2314	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Thewi_2315	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Thewi_2315	COG5322	oxidoreductase activity
Thewi_2320	COG0697	spore germination
Thewi_2321	COG0531	amino acid
Thewi_2322	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Thewi_2323	COG4684	Psort location CytoplasmicMembrane, score
Thewi_2324	COG4770	biotin carboxylase activity
Thewi_2326	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Thewi_2327	COG0346	lactoylglutathione lyase activity
Thewi_2329	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Thewi_2329	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Thewi_2330	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Thewi_2330	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Thewi_2333	COG3852	Histidine kinase
Thewi_2336	COG0037	tRNA processing
Thewi_2338	COG2208	phosphoserine phosphatase activity
Thewi_2340	COG3464	Transposase
Thewi_2341	COG0697	spore germination
Thewi_2342	COG1595	DNA-templated transcription, initiation
Thewi_2344	COG1131	(ABC) transporter
Thewi_2349	COG1063	alcohol dehydrogenase
Thewi_2350	COG0156	8-amino-7-oxononanoate synthase activity
Thewi_2355	COG2151	metal-sulfur cluster biosynthetic enzyme
Thewi_2358	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Thewi_2359	COG0022	dehydrogenase e1 component
Thewi_2367	COG3300	MHYT domain
Thewi_2367	COG5001	Diguanylate cyclase
Thewi_2383	COG1598	PFAM Uncharacterised protein family UPF0150
Thewi_2386	COG1215	transferase activity, transferring glycosyl groups
Thewi_2388	COG0745	RESPONSE REGULATOR receiver
Thewi_2392	COG2203	Gaf domain
Thewi_2392	COG2199	diguanylate cyclase activity
Thewi_2395	COG1366	Belongs to the anti-sigma-factor antagonist family
Thewi_2396	COG1366	Belongs to the anti-sigma-factor antagonist family
Thewi_2397	COG3328	transposase activity
Thewi_2415	COG4962	Type ii secretion system protein e
Thewi_2419	COG0739	heme binding
Thewi_2438	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Thewi_2448	COG1396	sequence-specific DNA binding
Thewi_2450	COG0248	Ppx GppA phosphatase
Thewi_2450	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Thewi_2451	COG1098	S1 RNA binding domain
Thewi_2458	COG2385	sporulation resulting in formation of a cellular spore
Thewi_2459	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Thewi_2460	COG0776	regulation of translation
Thewi_2461	COG3956	TIGRFAM MazG family protein
Thewi_2463	COG2814	Major facilitator Superfamily
Thewi_2464	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Thewi_2465	COG3850	Histidine kinase
Thewi_2465	COG5002	protein histidine kinase activity
Thewi_2466	COG0745	RESPONSE REGULATOR receiver
Thewi_2467	COG2033	superoxide reductase activity
Thewi_2469	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Thewi_2475	COG0037	tRNA processing
Thewi_2476	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Thewi_2484	COG0142	geranyltranstransferase activity
Thewi_2491	COG0454	-acetyltransferase
Thewi_2496	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Thewi_2500	COG1595	DNA-templated transcription, initiation
Thewi_2504	COG1725	Transcriptional regulator
Thewi_2505	COG1164	Oligoendopeptidase f
Thewi_2506	COG0165	Argininosuccinate lyase
Thewi_2509	COG0505	Belongs to the CarA family
Thewi_2510	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Thewi_2511	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Thewi_2512	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Thewi_2513	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Thewi_2516	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Thewi_2520	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Thewi_2520	COG0493	'glutamate synthase
Thewi_2523	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Thewi_2523	COG1796	DNA polymerase
Thewi_2527	COG0671	phosphoesterase, PA-phosphatase related
Thewi_2529	COG1132	(ABC) transporter
Thewi_2532	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Thewi_2532	COG1796	DNA polymerase
Thewi_2535	COG1454	alcohol dehydrogenase
Thewi_2535	COG1012	belongs to the aldehyde dehydrogenase family
Thewi_2537	COG0667	Aldo Keto reductase
Thewi_2540	COG0747	negative chemotaxis
Thewi_2541	COG0601	transmembrane transport
Thewi_2542	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Thewi_2543	COG0444	Belongs to the ABC transporter superfamily
Thewi_2544	COG4608	Belongs to the ABC transporter superfamily
Thewi_2549	COG1131	(ABC) transporter
Thewi_2551	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Thewi_2552	COG0018	arginyl-trna synthetase
Thewi_2554	COG1181	Belongs to the D-alanine--D-alanine ligase family
Thewi_2557	COG3409	Peptidoglycan-binding domain 1 protein
Thewi_2557	COG3773	Cell wall hydrolase
Thewi_2560	COG0531	amino acid
Thewi_2561	COG0697	spore germination
Thewi_2564	COG1802	Transcriptional regulator
Thewi_2565	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Thewi_2566	COG1388	LysM domain
Thewi_2567	COG4466	Protein conserved in bacteria
Thewi_2569	COG2002	toxin-antitoxin pair type II binding
Thewi_2570	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Thewi_2571	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Thewi_2574	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Thewi_2575	COG5002	protein histidine kinase activity
Thewi_2575	COG3850	Histidine kinase
Thewi_2577	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Thewi_2578	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Thewi_2579	COG2088	sporulation resulting in formation of a cellular spore
Thewi_2580	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Thewi_2581	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Thewi_2584	COG0071	Belongs to the small heat shock protein (HSP20) family
Thewi_2586	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thewi_2586	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thewi_2586	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thewi_2588	COG1349	DNA-binding transcription factor activity
Thewi_2589	COG2373	Large extracellular alpha-helical protein
Thewi_2593	COG0515	serine threonine protein kinase
Thewi_2593	COG3064	Membrane
Thewi_2593	COG4991	sh3 domain protein
Thewi_2596	COG0504	CTP synthase activity
Thewi_2597	COG2886	Uncharacterised protein family (UPF0175)
Thewi_2599	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Thewi_2601	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Thewi_2602	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Thewi_2605	COG0083	homoserine kinase activity
Thewi_2606	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Thewi_2607	COG0460	homoserine dehydrogenase
Thewi_2608	COG4492	Belongs to the UPF0735 family
Thewi_2610	COG0531	amino acid
Thewi_2611	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Thewi_2617	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Thewi_2618	COG1518	maintenance of DNA repeat elements
Thewi_2620	COG3340	Belongs to the peptidase S51 family
Thewi_2629	COG0822	iron-sulfur transferase activity
Thewi_2630	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Thewi_2632	COG0719	Fe-S assembly protein
Thewi_2633	COG0396	ATPase activity
Thewi_2634	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Thewi_2640	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Thewi_2642	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Thewi_2644	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Thewi_2645	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Thewi_2649	COG5002	protein histidine kinase activity
Thewi_2654	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Thewi_2655	COG0308	aminopeptidase N
Thewi_2658	COG2333	competence protein COMEC
Thewi_2658	COG0658	competence protein
Thewi_2668	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Thewi_2669	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Thewi_2670	COG0840	transmembrane signaling receptor activity
Thewi_2672	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Thewi_2673	COG0446	pyridine nucleotide-disulphide oxidoreductase
Thewi_2675	COG3344	reverse transcriptase
Thewi_2676	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Thewi_2677	COG1164	Oligoendopeptidase f
Thewi_2678	COG2226	methyltransferase
Thewi_2679	COG4555	ABC transporter
Thewi_2683	COG1132	(ABC) transporter
Thewi_2691	COG1132	(ABC) transporter
Thewi_2695	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Thewi_2696	COG0305	Participates in initiation and elongation during chromosome replication
Thewi_2702	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Thewi_2703	COG0629	single-stranded DNA binding
Thewi_2704	COG0360	Binds together with S18 to 16S ribosomal RNA
Thewi_2705	COG4481	Protein conserved in bacteria
Thewi_2706	COG0668	transmembrane transport
Thewi_2709	COG4242	Belongs to the peptidase S51 family
Thewi_2710	COG1597	lipid kinase activity
Thewi_2712	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Thewi_2713	COG1475	DNA binding
Thewi_2714	COG1192	Involved in chromosome partitioning
Thewi_2718	COG0445	tRNA wobble uridine modification
Thewi_2719	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Thewi_2720	COG1847	R3H domain protein
Thewi_2721	COG0706	membrane insertase activity
Thewi_2722	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Thewi_2723	COG0594	ribonuclease P activity