locus-tag	class	description
Tsac_0001	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Tsac_0001	COG2199	diguanylate cyclase activity
Tsac_0002	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Tsac_0003	COG1592	Rubrerythrin
Tsac_0009	COG5002	protein histidine kinase activity
Tsac_0010	COG0745	RESPONSE REGULATOR receiver
Tsac_0012	COG1609	Transcriptional regulator
Tsac_0014	COG0561	phosphatase activity
Tsac_0015	COG2323	membrane
Tsac_0022	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Tsac_0024	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Tsac_0026	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Tsac_0028	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Tsac_0029	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Tsac_0030	COG3711	transcriptional antiterminator
Tsac_0031	COG2190	(PTS) system
Tsac_0032	COG1263	PTS System
Tsac_0032	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Tsac_0034	COG3290	protein histidine kinase activity
Tsac_0034	COG0840	transmembrane signaling receptor activity
Tsac_0036	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Tsac_0038	COG2188	Transcriptional regulator
Tsac_0042	COG1744	ABC transporter substrate-binding protein PnrA-like
Tsac_0043	COG3404	Formiminotransferase-cyclodeaminase
Tsac_0053	COG0484	heat shock protein binding
Tsac_0058	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Tsac_0059	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
Tsac_0060	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Tsac_0065	COG1797	cobyrinic acid a,c-diamide synthase activity
Tsac_0066	COG1120	ATPase activity
Tsac_0067	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Tsac_0068	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Tsac_0073	COG5464	transposase or invertase
Tsac_0076	COG0531	amino acid
Tsac_0077	COG0116	Belongs to the methyltransferase superfamily
Tsac_0078	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Tsac_0080	COG1522	sequence-specific DNA binding
Tsac_0081	COG0436	Aminotransferase
Tsac_0085	COG0671	phosphoesterase, PA-phosphatase related
Tsac_0086	COG0735	belongs to the Fur family
Tsac_0087	COG0803	Belongs to the bacterial solute-binding protein 9 family
Tsac_0088	COG1121	(ABC) transporter
Tsac_0089	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Tsac_0100	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Tsac_0103	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Tsac_0104	COG0737	Belongs to the 5'-nucleotidase family
Tsac_0107	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Tsac_0107	COG1263	PTS System
Tsac_0108	COG2190	(PTS) system
Tsac_0109	COG1737	Transcriptional regulator
Tsac_0110	COG1486	melibiose metabolic process
Tsac_0111	COG1447	Phosphotransferase system cellobiose-specific component IIA
Tsac_0114	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Tsac_0116	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Tsac_0116	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Tsac_0117	COG0531	amino acid
Tsac_0118	COG1392	Phosphate transport regulator
Tsac_0122	COG0495	leucyl-tRNA aminoacylation
Tsac_0127	COG2201	protein-glutamate methylesterase activity
Tsac_0128	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Tsac_0129	COG3290	protein histidine kinase activity
Tsac_0129	COG0840	transmembrane signaling receptor activity
Tsac_0130	COG0643	Histidine kinase
Tsac_0130	COG2198	Histidine kinase
Tsac_0131	COG0835	chemotaxis
Tsac_0132	COG0582	viral genome integration into host DNA
Tsac_0133	COG0436	Aminotransferase
Tsac_0134	COG4214	carbohydrate transport
Tsac_0137	COG4213	ABC transporter substrate-binding protein
Tsac_0138	COG2207	Transcriptional regulator
Tsac_0138	COG4753	response regulator
Tsac_0139	COG2972	Histidine kinase
Tsac_0143	COG1028	Short-chain dehydrogenase reductase Sdr
Tsac_0144	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
Tsac_0145	COG1609	Transcriptional regulator
Tsac_0148	COG3250	beta-galactosidase activity
Tsac_0149	COG0395	ABC-type sugar transport system, permease component
Tsac_0151	COG1653	transport
Tsac_0153	COG0246	Mannitol dehydrogenase
Tsac_0154	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Tsac_0155	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Tsac_0156	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Tsac_0158	COG1349	DNA-binding transcription factor activity
Tsac_0160	COG0534	Mate efflux family protein
Tsac_0162	COG2721	sulfolactate sulfo-lyase activity
Tsac_0163	COG0246	Mannitol dehydrogenase
Tsac_0165	COG0395	ABC-type sugar transport system, permease component
Tsac_0166	COG1175	transmembrane transport
Tsac_0168	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
Tsac_0169	COG1609	Transcriptional regulator
Tsac_0170	COG1904	glucuronate isomerase
Tsac_0173	COG1388	LysM domain
Tsac_0173	COG0791	NLP P60 protein
Tsac_0175	COG0493	'glutamate synthase
Tsac_0179	COG0039	L-malate dehydrogenase activity
Tsac_0186	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Tsac_0189	COG0582	viral genome integration into host DNA
Tsac_0192	COG0586	Pfam SNARE associated Golgi protein
Tsac_0193	COG0297	glycogen (starch) synthase activity
Tsac_0200	COG1486	melibiose metabolic process
Tsac_0201	COG0395	ABC-type sugar transport system, permease component
Tsac_0202	COG1175	transmembrane transport
Tsac_0207	COG4753	response regulator
Tsac_0207	COG2207	Transcriptional regulator
Tsac_0208	COG1070	Carbohydrate kinase
Tsac_0209	COG4806	L-rhamnose isomerase
Tsac_0211	COG4656	Part of a membrane complex involved in electron transport
Tsac_0212	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
Tsac_0213	COG4869	propanediol catabolic process
Tsac_0214	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Tsac_0215	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Tsac_0216	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Tsac_0218	COG1063	alcohol dehydrogenase
Tsac_0228	COG1349	DNA-binding transcription factor activity
Tsac_0230	COG4716	Myosin-crossreactive antigen
Tsac_0232	COG3875	lactate racemase activity
Tsac_0233	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Tsac_0235	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Tsac_0239	COG0534	Mate efflux family protein
Tsac_0240	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Tsac_0242	COG2217	Heavy metal translocating P-type atpase
Tsac_0247	COG1131	(ABC) transporter
Tsac_0249	COG0864	Transcriptional regulator
Tsac_0250	COG0310	cobalt ion transport
Tsac_0251	COG0310	cobalt ion transport
Tsac_0253	COG1122	ATPase activity
Tsac_0254	COG2814	Major facilitator Superfamily
Tsac_0261	COG3958	Transketolase
Tsac_0262	COG3959	Transketolase, thiamine diphosphate binding domain
Tsac_0265	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Tsac_0266	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tsac_0267	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Tsac_0269	COG1609	Transcriptional regulator
Tsac_0270	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Tsac_0272	COG4214	carbohydrate transport
Tsac_0276	COG1070	Carbohydrate kinase
Tsac_0284	COG4632	Exopolysaccharide biosynthesis protein
Tsac_0284	COG5434	Belongs to the glycosyl hydrolase 28 family
Tsac_0285	COG1979	alcohol dehydrogenase
Tsac_0287	COG0457	Tetratricopeptide repeat
Tsac_0287	COG0463	Glycosyl transferase, family 2
Tsac_0288	COG0840	transmembrane signaling receptor activity
Tsac_0293	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Tsac_0296	COG4786	Flagellar basal body rod
Tsac_0298	COG1609	Transcriptional regulator
Tsac_0300	COG2385	sporulation resulting in formation of a cellular spore
Tsac_0308	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Tsac_0309	COG0531	amino acid
Tsac_0311	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Tsac_0313	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Tsac_0314	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Tsac_0316	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Tsac_0317	COG0698	ribose 5-phosphate isomerase
Tsac_0318	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Tsac_0319	COG0009	L-threonylcarbamoyladenylate synthase
Tsac_0322	COG2890	protein-(glutamine-N5) methyltransferase activity
Tsac_0323	COG3872	metal-dependent enzyme
Tsac_0324	COG1435	thymidine kinase activity
Tsac_0325	COG0254	rRNA binding
Tsac_0326	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Tsac_0329	COG0745	RESPONSE REGULATOR receiver
Tsac_0330	COG0860	N-Acetylmuramoyl-L-alanine amidase
Tsac_0330	COG2247	cell wall binding repeat
Tsac_0332	COG0577	efflux transmembrane transporter activity
Tsac_0332	COG1136	(ABC) transporter
Tsac_0333	COG1136	(ABC) transporter
Tsac_0335	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Tsac_0336	COG1132	(ABC) transporter
Tsac_0337	COG1132	(ABC) transporter
Tsac_0341	COG1175	transmembrane transport
Tsac_0343	COG1609	Transcriptional regulator
Tsac_0347	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Tsac_0347	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Tsac_0347	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tsac_0348	COG1105	Belongs to the carbohydrate kinase PfkB family
Tsac_0349	COG1349	DNA-binding transcription factor activity
Tsac_0356	COG0463	Glycosyl transferase, family 2
Tsac_0357	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Tsac_0359	COG2205	protein histidine kinase activity
Tsac_0359	COG2770	Histidine kinase
Tsac_0360	COG0745	RESPONSE REGULATOR receiver
Tsac_0361	COG2373	Large extracellular alpha-helical protein
Tsac_0366	COG0504	CTP synthase activity
Tsac_0370	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Tsac_0371	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Tsac_0372	COG1929	Belongs to the glycerate kinase type-1 family
Tsac_0374	COG0083	homoserine kinase activity
Tsac_0375	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Tsac_0376	COG0460	homoserine dehydrogenase
Tsac_0377	COG4492	Belongs to the UPF0735 family
Tsac_0379	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Tsac_0380	COG0674	pyruvate-flavodoxin oxidoreductase activity
Tsac_0380	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Tsac_0381	COG1013	pyruvate-flavodoxin oxidoreductase activity
Tsac_0382	COG1132	(ABC) transporter
Tsac_0384	COG1846	Transcriptional regulator
Tsac_0386	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Tsac_0387	COG1518	maintenance of DNA repeat elements
Tsac_0395	COG0822	iron-sulfur transferase activity
Tsac_0396	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Tsac_0397	COG0719	Fe-S assembly protein
Tsac_0398	COG0719	Fe-S assembly protein
Tsac_0416	COG1012	belongs to the aldehyde dehydrogenase family
Tsac_0416	COG1454	alcohol dehydrogenase
Tsac_0419	COG0667	Aldo Keto reductase
Tsac_0423	COG1924	4 iron, 4 sulfur cluster binding
Tsac_0434	COG3706	GGDEF domain
Tsac_0437	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tsac_0438	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Tsac_0442	COG5002	protein histidine kinase activity
Tsac_0443	COG0745	RESPONSE REGULATOR receiver
Tsac_0452	COG3547	Transposase (IS116 IS110 IS902 family)
Tsac_0464	COG4974	Belongs to the 'phage' integrase family
Tsac_0467	COG2801	Transposase and inactivated derivatives
Tsac_0484	COG3290	protein histidine kinase activity
Tsac_0488	COG0281	malic enzyme
Tsac_0489	COG3547	Transposase (IS116 IS110 IS902 family)
Tsac_0492	COG0446	pyridine nucleotide-disulphide oxidoreductase
Tsac_0494	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Tsac_0495	COG0395	ABC-type sugar transport system, permease component
Tsac_0496	COG1175	transmembrane transport
Tsac_0498	COG0673	inositol 2-dehydrogenase activity
Tsac_0501	COG3547	Transposase (IS116 IS110 IS902 family)
Tsac_0502	COG2207	Transcriptional regulator
Tsac_0502	COG1917	Cupin 2, conserved barrel domain protein
Tsac_0503	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tsac_0504	COG0745	RESPONSE REGULATOR receiver
Tsac_0507	COG2045	Belongs to the ComB family
Tsac_0512	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Tsac_0513	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Tsac_0515	COG3610	response to peptide
Tsac_0516	COG0840	transmembrane signaling receptor activity
Tsac_0518	COG3850	Histidine kinase
Tsac_0518	COG5002	protein histidine kinase activity
Tsac_0519	COG0745	RESPONSE REGULATOR receiver
Tsac_0521	COG2239	Acts as a magnesium transporter
Tsac_0522	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Tsac_0523	COG0305	Participates in initiation and elongation during chromosome replication
Tsac_0524	COG0359	binds to the 23S rRNA
Tsac_0525	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
Tsac_0528	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Tsac_0529	COG0629	single-stranded DNA binding
Tsac_0530	COG0360	Binds together with S18 to 16S ribosomal RNA
Tsac_0531	COG4481	Protein conserved in bacteria
Tsac_0532	COG0668	transmembrane transport
Tsac_0539	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Tsac_0540	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Tsac_0541	COG1475	DNA binding
Tsac_0542	COG1192	Involved in chromosome partitioning
Tsac_0544	COG1051	belongs to the nudix hydrolase family
Tsac_0544	COG1056	cytidyltransferase-related domain
Tsac_0545	COG0357	Ribosomal RNA small subunit methyltransferase G
Tsac_0546	COG0445	tRNA wobble uridine modification
Tsac_0547	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Tsac_0548	COG1847	R3H domain protein
Tsac_0549	COG0706	membrane insertase activity
Tsac_0550	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Tsac_0551	COG0594	ribonuclease P activity
Tsac_0552	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Tsac_0553	COG0592	DNA-directed DNA polymerase activity
Tsac_0557	COG3442	glutamine amidotransferase
Tsac_0559	COG0187	DNA topoisomerase II activity
Tsac_0560	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Tsac_0563	COG0440	acetolactate synthase activity
Tsac_0564	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Tsac_0565	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Tsac_0567	COG0066	3-isopropylmalate dehydratase activity
Tsac_0568	COG0473	3-isopropylmalate dehydrogenase activity
Tsac_0569	COG0129	dihydroxy-acid dehydratase activity
Tsac_0570	COG0028	Belongs to the TPP enzyme family
Tsac_0577	COG0681	Belongs to the peptidase S26 family
Tsac_0578	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Tsac_0580	COG1615	UPF0182 protein
Tsac_0583	COG1203	CRISPR-associated helicase, Cas3
Tsac_0593	COG1215	transferase activity, transferring glycosyl groups
Tsac_0594	COG0438	transferase activity, transferring glycosyl groups
Tsac_0595	COG0438	transferase activity, transferring glycosyl groups
Tsac_0597	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Tsac_0598	COG3547	Transposase (IS116 IS110 IS902 family)
Tsac_0599	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Tsac_0611	COG0590	tRNA wobble adenosine to inosine editing
Tsac_0612	COG2199	diguanylate cyclase activity
Tsac_0612	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Tsac_0613	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Tsac_0614	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Tsac_0615	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Tsac_0616	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Tsac_0618	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Tsac_0623	COG1028	Short-chain dehydrogenase reductase Sdr
Tsac_0624	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Tsac_0627	COG1187	pseudouridine synthase activity
Tsac_0628	COG1882	Formate acetyltransferase
Tsac_0629	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Tsac_0630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tsac_0631	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Tsac_0633	COG1573	uracil-dna glycosylase
Tsac_0634	COG1940	carbohydrate kinase activity
Tsac_0635	COG0519	Catalyzes the synthesis of GMP from XMP
Tsac_0636	COG1982	Orn Lys Arg decarboxylase major
Tsac_0637	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Tsac_0638	COG3870	Protein conserved in bacteria
Tsac_0640	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Tsac_0641	COG1774	PSP1 C-terminal conserved region
Tsac_0643	COG0730	response to heat
Tsac_0645	COG2235	arginine
Tsac_0646	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Tsac_0647	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Tsac_0648	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Tsac_0649	COG2002	toxin-antitoxin pair type II binding
Tsac_0650	COG2715	membrane protein required for spore maturation
Tsac_0651	COG0700	Nucleoside recognition
Tsac_0653	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tsac_0653	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tsac_0664	COG0084	hydrolase, TatD family'
Tsac_0666	COG3583	domain protein
Tsac_0666	COG3584	3D domain protein
Tsac_0667	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Tsac_0670	COG0489	protein tyrosine kinase activity
Tsac_0675	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Tsac_0675	COG2111	Na H antiporter
Tsac_0677	COG3260	NADH ubiquinone oxidoreductase 20
Tsac_0680	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tsac_0681	COG0375	protein maturation
Tsac_0683	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Tsac_0684	COG0298	carbon dioxide binding
Tsac_0686	COG0309	Hydrogenase expression formation protein (HypE)
Tsac_0687	COG3773	Cell wall hydrolase
Tsac_0687	COG3409	Peptidoglycan-binding domain 1 protein
Tsac_0689	COG0513	Belongs to the DEAD box helicase family
Tsac_0693	COG1175	transmembrane transport
Tsac_0694	COG3833	ABC-type maltose transport systems, permease component
Tsac_0695	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Tsac_0702	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Tsac_0704	COG2221	Nitrite and sulphite reductase 4Fe-4S
Tsac_0722	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Tsac_0726	COG0789	Transcriptional regulator
Tsac_0727	COG1664	Polymer-forming cytoskeletal
Tsac_0729	COG0071	Belongs to the small heat shock protein (HSP20) family
Tsac_0731	COG1609	Transcriptional regulator
Tsac_0732	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Tsac_0733	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Tsac_0735	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Tsac_0736	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Tsac_0738	COG5002	protein histidine kinase activity
Tsac_0738	COG3850	Histidine kinase
Tsac_0739	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tsac_0742	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Tsac_0743	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Tsac_0744	COG2002	toxin-antitoxin pair type II binding
Tsac_0746	COG4466	Protein conserved in bacteria
Tsac_0749	COG1802	Transcriptional regulator
Tsac_0752	COG0697	spore germination
Tsac_0753	COG0531	amino acid
Tsac_0756	COG1982	Orn Lys Arg decarboxylase major
Tsac_0757	COG3773	Cell wall hydrolase
Tsac_0757	COG3409	Peptidoglycan-binding domain 1 protein
Tsac_0758	COG2959	enzyme of heme biosynthesis
Tsac_0761	COG1175	transmembrane transport
Tsac_0762	COG0395	ABC-type sugar transport system, permease component
Tsac_0763	COG1609	Transcriptional regulator
Tsac_0765	COG1438	arginine binding
Tsac_0766	COG0531	amino acid
Tsac_0767	COG2235	arginine
Tsac_0768	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Tsac_0771	COG1438	arginine binding
Tsac_0772	COG1181	Belongs to the D-alanine--D-alanine ligase family
Tsac_0774	COG0018	arginyl-trna synthetase
Tsac_0775	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Tsac_0776	COG1131	(ABC) transporter
Tsac_0780	COG2197	response regulator
Tsac_0782	COG0531	amino acid
Tsac_0784	COG0667	Aldo Keto reductase
Tsac_0787	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Tsac_0788	COG3859	Proton-coupled thiamine transporter YuaJ
Tsac_0790	COG0671	phosphoesterase, PA-phosphatase related
Tsac_0794	COG5434	Belongs to the glycosyl hydrolase 28 family
Tsac_0794	COG4632	Exopolysaccharide biosynthesis protein
Tsac_0795	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Tsac_0802	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Tsac_0803	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Tsac_0805	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Tsac_0806	COG0505	Belongs to the CarA family
Tsac_0809	COG0165	Argininosuccinate lyase
Tsac_0810	COG0446	pyridine nucleotide-disulphide oxidoreductase
Tsac_0811	COG0586	Pfam SNARE associated Golgi protein
Tsac_0812	COG1321	iron dependent repressor
Tsac_0813	COG1914	H( )-stimulated, divalent metal cation uptake system
Tsac_0814	COG2033	superoxide reductase activity
Tsac_0815	COG1027	Aspartate ammonia-lyase
Tsac_0819	COG3956	TIGRFAM MazG family protein
Tsac_0820	COG0776	regulation of translation
Tsac_0821	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Tsac_0822	COG2385	sporulation resulting in formation of a cellular spore
Tsac_0828	COG1098	S1 RNA binding domain
Tsac_0829	COG0248	Ppx GppA phosphatase
Tsac_0829	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Tsac_0840	COG1396	sequence-specific DNA binding
Tsac_0846	COG1598	PFAM Uncharacterised protein family UPF0150
Tsac_0848	COG3620	sequence-specific DNA binding
Tsac_0868	COG0739	heme binding
Tsac_0881	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Tsac_0890	COG2076	Multidrug Resistance protein
Tsac_0897	COG0726	polysaccharide deacetylase
Tsac_0902	COG5464	transposase or invertase
Tsac_0904	COG0840	transmembrane signaling receptor activity
Tsac_0907	COG0860	N-Acetylmuramoyl-L-alanine amidase
Tsac_0909	COG2233	PERMEase
Tsac_0911	COG0842	Transport permease protein
Tsac_0912	COG1131	(ABC) transporter
Tsac_0914	COG1309	transcriptional regulator
Tsac_0920	COG1131	(ABC) transporter
Tsac_0922	COG1595	DNA-templated transcription, initiation
Tsac_0924	COG3830	Belongs to the UPF0237 family
Tsac_0926	COG2226	methyltransferase
Tsac_0931	COG2226	methyltransferase
Tsac_0932	COG2208	phosphoserine phosphatase activity
Tsac_0934	COG0515	serine threonine protein kinase
Tsac_0934	COG2815	serine threonine protein kinase
Tsac_0935	COG0037	tRNA processing
Tsac_0938	COG1917	Cupin 2, conserved barrel domain protein
Tsac_0938	COG4977	sequence-specific DNA binding
Tsac_0940	COG3852	Histidine kinase
Tsac_0941	COG2759	Belongs to the formate--tetrahydrofolate ligase family
Tsac_0943	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Tsac_0945	COG4770	biotin carboxylase activity
Tsac_0946	COG4684	Psort location CytoplasmicMembrane, score
Tsac_0947	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Tsac_0949	COG0697	spore germination
Tsac_0954	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Tsac_0954	COG5322	oxidoreductase activity
Tsac_0955	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Tsac_0956	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Tsac_0957	COG0302	gtp cyclohydrolase
Tsac_0958	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Tsac_0959	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Tsac_0960	COG0720	synthase
Tsac_0961	COG1489	DNA binding
Tsac_0962	COG4224	UPF0291 protein
Tsac_0966	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Tsac_0967	COG0745	RESPONSE REGULATOR receiver
Tsac_0967	COG3706	GGDEF domain
Tsac_0969	COG3711	transcriptional antiterminator
Tsac_0969	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tsac_0970	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Tsac_0970	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Tsac_0970	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tsac_0971	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Tsac_0971	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Tsac_0971	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tsac_0972	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Tsac_0973	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Tsac_0974	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Tsac_0975	COG0281	malic enzyme
Tsac_0978	COG3880	PFAM UvrB UvrC protein
Tsac_0979	COG3869	Catalyzes the specific phosphorylation of arginine residues in
Tsac_0980	COG0542	response to heat
Tsac_0981	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Tsac_0983	COG4956	integral membrane protein (PIN domain superfamily)
Tsac_0984	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Tsac_0986	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Tsac_0989	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Tsac_0990	COG1045	serine acetyltransferase
Tsac_0991	COG0215	cysteine-tRNA ligase activity
Tsac_0994	COG3688	RNA-binding protein containing a PIN domain
Tsac_0995	COG1595	DNA-templated transcription, initiation
Tsac_0996	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Tsac_0997	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Tsac_0998	COG0250	Participates in transcription elongation, termination and antitermination
Tsac_0999	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Tsac_1002	COG0222	ribosome binding
Tsac_1003	COG0085	RNA polymerase activity
Tsac_1004	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Tsac_1005	COG1358	cellular component organization or biogenesis
Tsac_1006	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Tsac_1007	COG0049	tRNA binding
Tsac_1008	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Tsac_1009	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Tsac_1010	COG0051	transcription antitermination factor activity, RNA binding
Tsac_1011	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Tsac_1012	COG0088	Forms part of the polypeptide exit tunnel
Tsac_1013	COG0089	rRNA binding
Tsac_1014	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Tsac_1015	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Tsac_1016	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Tsac_1017	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Tsac_1018	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Tsac_1019	COG0255	Belongs to the universal ribosomal protein uL29 family
Tsac_1020	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Tsac_1021	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Tsac_1022	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Tsac_1023	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Tsac_1025	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Tsac_1027	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Tsac_1028	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Tsac_1029	COG1841	ribosomal large subunit assembly
Tsac_1030	COG0200	Binds to the 23S rRNA
Tsac_1031	COG0201	protein transport
Tsac_1032	COG0563	adenylate kinase activity
Tsac_1035	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Tsac_1036	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Tsac_1037	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Tsac_1038	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Tsac_1039	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Tsac_1040	COG0202	RNA polymerase activity
Tsac_1041	COG0203	ribosomal protein L17
Tsac_1042	COG1122	ATPase activity
Tsac_1043	COG1122	ATPase activity
Tsac_1044	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Tsac_1045	COG0101	tRNA pseudouridine synthase activity
Tsac_1046	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Tsac_1047	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Tsac_1049	COG1454	alcohol dehydrogenase
Tsac_1050	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Tsac_1055	COG1388	LysM domain
Tsac_1055	COG3942	CHAP domain
Tsac_1057	COG0714	Associated with various cellular activities
Tsac_1058	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
Tsac_1059	COG1305	Transglutaminase-like
Tsac_1061	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
Tsac_1070	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Tsac_1088	COG2226	methyltransferase
Tsac_1089	COG1619	proteins homologs of microcin C7 resistance protein MccF
Tsac_1112	COG3012	SEC-C Motif Domain Protein
Tsac_1122	COG0640	Transcriptional regulator
Tsac_1127	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Tsac_1128	COG0456	acetyltransferase
Tsac_1130	COG0561	phosphatase activity
Tsac_1131	COG2703	oxygen carrier activity
Tsac_1134	COG3973	AAA domain
Tsac_1135	COG0432	Pfam Uncharacterised protein family UPF0047
Tsac_1138	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Tsac_1138	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Tsac_1140	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Tsac_1142	COG2337	Toxic component of a toxin-antitoxin (TA) module
Tsac_1146	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
Tsac_1147	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Tsac_1149	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Tsac_1150	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Tsac_1151	COG0157	Belongs to the NadC ModD family
Tsac_1153	COG1773	rubredoxin
Tsac_1155	COG0673	inositol 2-dehydrogenase activity
Tsac_1156	COG1609	Transcriptional regulator
Tsac_1157	COG1653	transport
Tsac_1159	COG0395	ABC-type sugar transport system, permease component
Tsac_1163	COG1175	transmembrane transport
Tsac_1164	COG0395	ABC-type sugar transport system, permease component
Tsac_1166	COG4124	Belongs to the glycosyl hydrolase 26 family
Tsac_1167	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
Tsac_1167	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Tsac_1168	COG3459	Glycosyltransferase 36 associated
Tsac_1169	COG1725	Transcriptional regulator
Tsac_1171	COG0330	HflC and HflK could
Tsac_1173	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Tsac_1176	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Tsac_1178	COG0131	Imidazoleglycerol-phosphate dehydratase
Tsac_1179	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Tsac_1182	COG0140	phosphoribosyl-ATP diphosphatase activity
Tsac_1182	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Tsac_1183	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Tsac_1185	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Tsac_1186	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
Tsac_1188	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Tsac_1193	COG0640	Transcriptional regulator
Tsac_1198	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Tsac_1200	COG0798	PFAM Bile acid sodium symporter
Tsac_1203	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Tsac_1204	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Tsac_1206	COG0446	pyridine nucleotide-disulphide oxidoreductase
Tsac_1208	COG3290	protein histidine kinase activity
Tsac_1208	COG3829	transcription factor binding
Tsac_1209	COG2376	Dihydroxyacetone kinase
Tsac_1211	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
Tsac_1213	COG0443	Heat shock 70 kDa protein
Tsac_1220	COG0849	cell division
Tsac_1224	COG1131	(ABC) transporter
Tsac_1227	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Tsac_1230	COG3842	ATPase activity
Tsac_1233	COG0437	4 iron, 4 sulfur cluster binding
Tsac_1234	COG0069	glutamate synthase activity
Tsac_1234	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Tsac_1235	COG0067	glutamate synthase
Tsac_1236	COG3835	regulator
Tsac_1237	COG2884	Cell division ATP-binding protein ftsE
Tsac_1238	COG2177	Part of the ABC transporter FtsEX involved in
Tsac_1239	COG0739	heme binding
Tsac_1240	COG0793	Belongs to the peptidase S41A family
Tsac_1241	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tsac_1242	COG2045	Belongs to the ComB family
Tsac_1243	COG0556	nucleotide-excision repair
Tsac_1245	COG1716	ATPase activity
Tsac_1247	COG0768	penicillin binding
Tsac_1250	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Tsac_1252	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Tsac_1252	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Tsac_1253	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Tsac_1255	COG1940	carbohydrate kinase activity
Tsac_1256	COG0318	PFAM AMP-dependent synthetase and ligase
Tsac_1257	COG1609	Transcriptional regulator
Tsac_1258	COG0673	inositol 2-dehydrogenase activity
Tsac_1261	COG0673	inositol 2-dehydrogenase activity
Tsac_1262	COG3250	beta-galactosidase activity
Tsac_1263	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Tsac_1263	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Tsac_1264	COG1447	Phosphotransferase system cellobiose-specific component IIA
Tsac_1265	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
Tsac_1269	COG2723	6-phospho-beta-galactosidase activity
Tsac_1271	COG4209	transmembrane transport
Tsac_1272	COG0395	ABC-type sugar transport system, permease component
Tsac_1276	COG1874	Beta-galactosidase
Tsac_1277	COG1501	Belongs to the glycosyl hydrolase 31 family
Tsac_1278	COG3534	alpha-L-arabinofuranosidase
Tsac_1281	COG1129	ABC transporter
Tsac_1282	COG1172	Belongs to the binding-protein-dependent transport system permease family
Tsac_1283	COG2160	L-arabinose isomerase activity
Tsac_1284	COG1069	ribulokinase activity
Tsac_1285	COG0235	Class ii aldolase
Tsac_1287	COG1609	Transcriptional regulator
Tsac_1288	COG0371	Dehydrogenase
Tsac_1289	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Tsac_1294	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
Tsac_1295	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Tsac_1296	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Tsac_1297	COG1940	carbohydrate kinase activity
Tsac_1302	COG0726	polysaccharide deacetylase
Tsac_1303	COG1477	protein flavinylation
Tsac_1305	COG0768	penicillin binding
Tsac_1306	COG1793	dna ligase
Tsac_1306	COG3285	dna ligase
Tsac_1307	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
Tsac_1308	COG0791	NLP P60 protein
Tsac_1308	COG1388	LysM domain
Tsac_1313	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Tsac_1313	COG2755	lipolytic protein G-D-S-L family
Tsac_1314	COG0531	amino acid
Tsac_1316	COG0644	oxidoreductase
Tsac_1317	COG2608	mercury ion transmembrane transporter activity
Tsac_1319	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Tsac_1319	COG1796	DNA polymerase
Tsac_1323	COG1914	H( )-stimulated, divalent metal cation uptake system
Tsac_1325	COG2226	methyltransferase
Tsac_1335	COG2217	Heavy metal translocating P-type atpase
Tsac_1337	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Tsac_1339	COG1660	Displays ATPase and GTPase activities
Tsac_1347	COG0840	transmembrane signaling receptor activity
Tsac_1349	COG1175	transmembrane transport
Tsac_1350	COG3833	ABC-type maltose transport systems, permease component
Tsac_1353	COG1426	Protein conserved in bacteria
Tsac_1354	COG0366	Alpha amylase catalytic
Tsac_1357	COG1481	regulation of sporulation
Tsac_1358	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tsac_1359	COG4109	DRTGG domain
Tsac_1362	COG0205	6-phosphofructokinase activity
Tsac_1364	COG0824	Thioesterase
Tsac_1366	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Tsac_1370	COG2801	Transposase and inactivated derivatives
Tsac_1375	COG1846	Transcriptional regulator
Tsac_1376	COG2814	Major facilitator Superfamily
Tsac_1378	COG5002	protein histidine kinase activity
Tsac_1382	COG0778	Nitroreductase
Tsac_1385	COG1199	ATP-dependent helicase activity
Tsac_1385	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Tsac_1387	COG1073	alpha beta
Tsac_1387	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
Tsac_1387	COG3064	Membrane
Tsac_1388	COG2195	Cleaves the N-terminal amino acid of tripeptides
Tsac_1389	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Tsac_1390	COG0778	Nitroreductase
Tsac_1396	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Tsac_1396	COG0646	methionine synthase
Tsac_1397	COG0646	methionine synthase
Tsac_1397	COG1410	methionine synthase
Tsac_1398	COG3546	catalase activity
Tsac_1401	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Tsac_1402	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Tsac_1403	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
Tsac_1405	COG0667	Aldo Keto reductase
Tsac_1406	COG0656	L-ascorbic acid biosynthetic process
Tsac_1410	COG0789	Transcriptional regulator
Tsac_1411	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Tsac_1412	COG1234	tRNA 3'-trailer cleavage
Tsac_1413	COG0544	peptidyl-prolyl cis-trans isomerase activity
Tsac_1414	COG0740	serine-type endopeptidase activity
Tsac_1415	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Tsac_1417	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Tsac_1418	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Tsac_1419	COG0356	it plays a direct role in the translocation of protons across the membrane
Tsac_1420	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Tsac_1421	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Tsac_1422	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Tsac_1423	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Tsac_1424	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Tsac_1425	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Tsac_1426	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Tsac_1429	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Tsac_1429	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Tsac_1430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Tsac_1431	COG1116	anion transmembrane transporter activity
Tsac_1432	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Tsac_1434	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Tsac_1435	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
Tsac_1443	COG1802	Transcriptional regulator
Tsac_1445	COG4209	transmembrane transport
Tsac_1446	COG0395	ABC-type sugar transport system, permease component
Tsac_1449	COG0673	inositol 2-dehydrogenase activity
Tsac_1452	COG3664	PFAM glycoside hydrolase family 39
Tsac_1453	COG3458	cephalosporin-C deacetylase activity
Tsac_1454	COG4753	response regulator
Tsac_1454	COG4753	response regulator
Tsac_1454	COG2207	Transcriptional regulator
Tsac_1454	COG2207	Transcriptional regulator
Tsac_1455	COG3275	phosphorelay sensor kinase activity
Tsac_1457	COG4209	transmembrane transport
Tsac_1458	COG0395	ABC-type sugar transport system, permease component
Tsac_1462	COG1653	transport
Tsac_1463	COG1175	transmembrane transport
Tsac_1464	COG0395	ABC-type sugar transport system, permease component
Tsac_1468	COG1136	(ABC) transporter
Tsac_1471	COG1942	4-Oxalocrotonate Tautomerase
Tsac_1476	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Tsac_1478	COG3949	Membrane
Tsac_1480	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Tsac_1482	COG0105	UTP biosynthetic process
Tsac_1486	COG0426	domain, Protein
Tsac_1487	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Tsac_1488	COG0671	phosphoesterase, PA-phosphatase related
Tsac_1490	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Tsac_1491	COG1606	tRNA processing
Tsac_1492	COG1691	(AIR) carboxylase
Tsac_1493	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Tsac_1494	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Tsac_1495	COG1268	BioY protein
Tsac_1496	COG0525	valine-tRNA ligase activity
Tsac_1498	COG0285	dihydrofolate synthase activity
Tsac_1503	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Tsac_1507	COG1609	Transcriptional regulator
Tsac_1510	COG1175	transmembrane transport
Tsac_1511	COG0395	ABC-type sugar transport system, permease component
Tsac_1513	COG2182	Extracellular solute-binding protein
Tsac_1517	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Tsac_1518	COG0726	polysaccharide deacetylase
Tsac_1521	COG2171	N-acyltransferase activity
Tsac_1522	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Tsac_1523	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Tsac_1524	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Tsac_1528	COG3706	GGDEF domain
Tsac_1528	COG0745	RESPONSE REGULATOR receiver
Tsac_1529	COG1252	NADH dehydrogenase
Tsac_1532	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Tsac_1533	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Tsac_1536	COG1388	LysM domain
Tsac_1536	COG3858	chitin binding
Tsac_1538	COG0739	heme binding
Tsac_1539	COG0438	transferase activity, transferring glycosyl groups
Tsac_1547	COG0438	transferase activity, transferring glycosyl groups
Tsac_1548	COG1937	Protein conserved in bacteria
Tsac_1550	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Tsac_1555	COG0301	tRNA thio-modification
Tsac_1556	COG0012	GTP binding
Tsac_1558	COG0612	Peptidase, M16
Tsac_1559	COG0612	Peptidase, M16
Tsac_1563	COG0768	penicillin binding
Tsac_1564	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Tsac_1565	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Tsac_1566	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Tsac_1568	COG0772	Belongs to the SEDS family
Tsac_1569	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Tsac_1570	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Tsac_1573	COG3856	small basic protein
Tsac_1574	COG0849	cell division
Tsac_1575	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Tsac_1577	COG1191	sigma factor activity
Tsac_1578	COG1191	sigma factor activity
Tsac_1579	COG1873	PFAM PRC-barrel domain
Tsac_1581	COG0745	RESPONSE REGULATOR receiver
Tsac_1582	COG5002	protein histidine kinase activity
Tsac_1583	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Tsac_1584	COG0840	transmembrane signaling receptor activity
Tsac_1585	COG0573	inorganic phosphate transmembrane transporter activity
Tsac_1586	COG0581	inorganic phosphate transmembrane transporter activity
Tsac_1587	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Tsac_1588	COG0704	Plays a role in the regulation of phosphate uptake
Tsac_1595	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Tsac_1601	COG0584	glycerophosphoryl diester phosphodiesterase
Tsac_1603	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Tsac_1604	COG1968	undecaprenyl-diphosphatase activity
Tsac_1607	COG3069	C4-dicarboxylate transmembrane transporter activity
Tsac_1608	COG0426	domain, Protein
Tsac_1610	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Tsac_1611	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Tsac_1613	COG1164	Oligoendopeptidase f
Tsac_1615	COG1760	l-serine dehydratase
Tsac_1616	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Tsac_1617	COG1605	Chorismate mutase
Tsac_1617	COG0077	Prephenate dehydratase
Tsac_1618	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Tsac_1619	COG0287	Prephenate dehydrogenase
Tsac_1620	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Tsac_1621	COG0745	RESPONSE REGULATOR receiver
Tsac_1622	COG5002	protein histidine kinase activity
Tsac_1624	COG3409	Peptidoglycan-binding domain 1 protein
Tsac_1624	COG3773	Cell wall hydrolase
Tsac_1625	COG2119	membrane
Tsac_1630	COG1940	carbohydrate kinase activity
Tsac_1631	COG0363	glucosamine-6-phosphate deaminase activity
Tsac_1632	COG0785	Cytochrome C biogenesis protein
Tsac_1633	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Tsac_1636	COG2205	protein histidine kinase activity
Tsac_1638	COG1982	Orn Lys Arg decarboxylase major
Tsac_1639	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Tsac_1640	COG0477	Major facilitator Superfamily
Tsac_1641	COG0789	Transcriptional regulator
Tsac_1642	COG2078	PFAM AMMECR1 domain protein
Tsac_1642	COG3885	ferrous iron binding
Tsac_1644	COG4166	transmembrane transport
Tsac_1647	COG0444	Belongs to the ABC transporter superfamily
Tsac_1649	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Tsac_1650	COG0181	hydroxymethylbilane synthase activity
Tsac_1652	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Tsac_1653	COG1648	precorrin-2 dehydrogenase activity
Tsac_1653	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Tsac_1654	COG0113	porphobilinogen synthase activity
Tsac_1657	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Tsac_1661	COG0175	sulfate reduction
Tsac_1664	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Tsac_1665	COG0175	sulfate reduction
Tsac_1669	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Tsac_1671	COG0494	nUDIX hydrolase
Tsac_1672	COG1739	Uncharacterized protein family UPF0029
Tsac_1676	COG0730	response to heat
Tsac_1677	COG0217	transcriptional regulatory protein
Tsac_1678	COG0835	chemotaxis
Tsac_1680	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Tsac_1681	COG0632	four-way junction helicase activity
Tsac_1682	COG2255	four-way junction helicase activity
Tsac_1684	COG2247	cell wall binding repeat
Tsac_1684	COG2385	sporulation resulting in formation of a cellular spore
Tsac_1685	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Tsac_1686	COG0343	queuine tRNA-ribosyltransferase activity
Tsac_1690	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Tsac_1691	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Tsac_1694	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Tsac_1694	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Tsac_1695	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Tsac_1696	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Tsac_1698	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tsac_1701	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Tsac_1702	COG0540	Belongs to the ATCase OTCase family
Tsac_1703	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Tsac_1705	COG0543	2 iron, 2 sulfur cluster binding
Tsac_1706	COG0167	dihydroorotate dehydrogenase activity
Tsac_1707	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Tsac_1712	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Tsac_1713	COG1561	YicC-like family, N-terminal region
Tsac_1715	COG0194	GDP metabolic process
Tsac_1717	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Tsac_1718	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Tsac_1719	COG0242	peptide deformylase activity
Tsac_1720	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Tsac_1722	COG2738	Putative neutral zinc metallopeptidase
Tsac_1723	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Tsac_1723	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Tsac_1724	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Tsac_1725	COG0631	protein serine/threonine phosphatase activity
Tsac_1726	COG0515	serine threonine protein kinase
Tsac_1726	COG2815	serine threonine protein kinase
Tsac_1727	COG1162	GTPase activity
Tsac_1728	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Tsac_1733	COG1302	Protein conserved in bacteria
Tsac_1734	COG1461	Dihydroxyacetone kinase
Tsac_1735	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Tsac_1736	COG1307	EDD domain protein, DegV family
Tsac_1739	COG0742	ribosomal rna small subunit methyltransferase
Tsac_1740	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Tsac_1742	COG3314	Sporulation integral membrane protein YlbJ
Tsac_1744	COG0280	phosphate acetyltransferase
Tsac_1745	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Tsac_1746	COG1399	metal-binding, possibly nucleic acid-binding protein
Tsac_1747	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Tsac_1748	COG2030	dehydratase
Tsac_1749	COG0416	fatty acid biosynthetic process
Tsac_1750	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Tsac_1751	COG2070	2-Nitropropane dioxygenase
Tsac_1752	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Tsac_1753	COG1028	Short-chain dehydrogenase reductase Sdr
Tsac_1754	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Tsac_1755	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Tsac_1756	COG0571	ribonuclease III activity
Tsac_1757	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Tsac_1758	COG2359	stage V sporulation protein S
Tsac_1759	COG1196	nuclear chromosome segregation
Tsac_1760	COG0552	protein localization to endoplasmic reticulum
Tsac_1761	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
Tsac_1762	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Tsac_1763	COG0228	four-way junction DNA binding
Tsac_1764	COG1837	Belongs to the UPF0109 family
Tsac_1765	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Tsac_1766	COG0336	Belongs to the RNA methyltransferase TrmD family
Tsac_1767	COG0335	large ribosomal subunit rRNA binding
Tsac_1769	COG0606	chelatase, subunit chli
Tsac_1770	COG0180	Tryptophanyl-tRNA synthetase
Tsac_1771	COG0792	nuclease activity
Tsac_1772	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Tsac_1773	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Tsac_1773	COG0758	DNA mediated transformation
Tsac_1774	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Tsac_1775	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Tsac_1776	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Tsac_1778	COG1815	bacterial-type flagellum-dependent cell motility
Tsac_1779	COG1558	bacterial-type flagellum-dependent cell motility
Tsac_1780	COG1677	Flagellar hook-basal body complex protein FliE
Tsac_1781	COG1766	The M ring may be actively involved in energy transduction
Tsac_1782	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Tsac_1784	COG1157	protein secretion by the type III secretion system
Tsac_1788	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Tsac_1791	COG1580	Controls the rotational direction of flagella during chemotaxis
Tsac_1792	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Tsac_1793	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Tsac_1793	COG1776	CheC inhibitor of MCP methylation
Tsac_1794	COG2201	protein-glutamate methylesterase activity
Tsac_1796	COG1338	Plays a role in the flagellum-specific transport system
Tsac_1797	COG1987	bacterial-type flagellum assembly
Tsac_1798	COG1684	flagellar biosynthetic protein fliR
Tsac_1799	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Tsac_1800	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Tsac_1802	COG0455	bacterial-type flagellum organization
Tsac_1804	COG0643	Histidine kinase
Tsac_1804	COG2198	Histidine kinase
Tsac_1805	COG0835	chemotaxis
Tsac_1806	COG1776	CheC inhibitor of MCP methylation
Tsac_1807	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Tsac_1808	COG1191	sigma factor activity
Tsac_1811	COG0052	Belongs to the universal ribosomal protein uS2 family
Tsac_1812	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Tsac_1813	COG0528	UMP kinase activity
Tsac_1814	COG0233	cytoplasmic translational termination
Tsac_1816	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Tsac_1817	COG4589	Belongs to the CDS family
Tsac_1818	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Tsac_1819	COG0750	zinc metalloprotease
Tsac_1820	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Tsac_1821	COG0463	Glycosyl transferase, family 2
Tsac_1822	COG2176	DNA-directed DNA polymerase activity
Tsac_1823	COG0779	Required for maturation of 30S ribosomal subunits
Tsac_1824	COG0195	Participates in both transcription termination and antitermination
Tsac_1827	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Tsac_1828	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Tsac_1829	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Tsac_1830	COG0196	riboflavin kinase activity
Tsac_1833	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Tsac_1834	COG1185	polyribonucleotide nucleotidyltransferase activity
Tsac_1835	COG0726	polysaccharide deacetylase
Tsac_1836	COG0612	Peptidase, M16
Tsac_1837	COG0756	dUTP diphosphatase activity
Tsac_1839	COG0527	aspartate kinase activity
Tsac_1840	COG0740	serine-type endopeptidase activity
Tsac_1842	COG1674	ftsk spoiiie
Tsac_1843	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tsac_1844	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Tsac_1845	COG1546	Belongs to the CinA family
Tsac_1845	COG1058	Belongs to the CinA family
Tsac_1846	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Tsac_1847	COG2137	regulation of response to DNA damage stimulus
Tsac_1852	COG0419	ATPase involved in DNA repair
Tsac_1853	COG1418	mRNA catabolic process
Tsac_1854	COG1692	metallophosphoesterase
Tsac_1855	COG2359	stage V sporulation protein S
Tsac_1856	COG0613	PHP domain protein
Tsac_1859	COG0017	Asparaginyl-tRNA synthetase
Tsac_1860	COG0464	growth
Tsac_1861	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
Tsac_1862	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Tsac_1863	COG4974	Belongs to the 'phage' integrase family
Tsac_1864	COG0328	RNA-DNA hybrid ribonuclease activity
Tsac_1865	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Tsac_1866	COG1923	regulation of RNA biosynthetic process
Tsac_1867	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Tsac_1868	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Tsac_1869	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Tsac_1872	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Tsac_1873	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Tsac_1874	COG0539	negative regulation of cytoplasmic translation
Tsac_1875	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Tsac_1877	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Tsac_1879	COG2081	HI0933 family
Tsac_1882	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Tsac_1884	COG1388	LysM domain
Tsac_1886	COG0010	Belongs to the arginase family
Tsac_1887	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Tsac_1889	COG1187	pseudouridine synthase activity
Tsac_1890	COG0445	tRNA wobble uridine modification
Tsac_1892	COG1686	Belongs to the peptidase S11 family
Tsac_1893	COG3874	Sporulation protein YtfJ
Tsac_1895	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Tsac_1896	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Tsac_1897	COG1994	Peptidase M50
Tsac_1898	COG0617	tRNA 3'-terminal CCA addition
Tsac_1902	COG3360	Dodecin
Tsac_1904	COG1191	sigma factor activity
Tsac_1905	COG2172	sigma factor antagonist activity
Tsac_1907	COG1686	Belongs to the peptidase S11 family
Tsac_1908	COG4974	Belongs to the 'phage' integrase family
Tsac_1909	COG1300	Membrane
Tsac_1910	COG1379	DNA repair
Tsac_1911	COG0494	nUDIX hydrolase
Tsac_1918	COG0750	zinc metalloprotease
Tsac_1919	COG0497	DNA recombination
Tsac_1920	COG1438	arginine binding
Tsac_1921	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Tsac_1922	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Tsac_1923	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Tsac_1925	COG0142	geranyltranstransferase activity
Tsac_1926	COG1722	exodeoxyribonuclease VII activity
Tsac_1927	COG1570	exodeoxyribonuclease VII activity
Tsac_1928	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Tsac_1929	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Tsac_1930	COG1302	Protein conserved in bacteria
Tsac_1938	COG3854	ATPases associated with a variety of cellular activities
Tsac_1940	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Tsac_1941	COG0006	proline dipeptidase activity
Tsac_1942	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Tsac_1943	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Tsac_1944	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Tsac_1945	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Tsac_1954	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Tsac_1956	COG1459	type II secretion system
Tsac_1959	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Tsac_1961	COG1191	sigma factor activity
Tsac_1962	COG0582	viral genome integration into host DNA
Tsac_1968	COG0358	DNA primase activity
Tsac_1970	COG0768	penicillin binding
Tsac_1973	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Tsac_1974	COG3679	Belongs to the UPF0342 family
Tsac_1975	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Tsac_1976	COG0735	belongs to the Fur family
Tsac_1977	COG3906	Belongs to the UPF0473 family
Tsac_1979	COG4472	Bacterial protein of unknown function (DUF965)
Tsac_1980	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Tsac_1981	COG0628	permease
Tsac_1990	COG1959	2 iron, 2 sulfur cluster binding
Tsac_1991	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Tsac_1996	COG3118	belongs to the thioredoxin family
Tsac_1997	COG1937	Protein conserved in bacteria
Tsac_1998	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Tsac_2000	COG0124	histidyl-tRNA synthetase
Tsac_2001	COG0564	pseudouridine synthase activity
Tsac_2002	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Tsac_2004	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Tsac_2008	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Tsac_2012	COG0134	indole-3-glycerol-phosphate synthase activity
Tsac_2013	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Tsac_2014	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Tsac_2014	COG0512	Glutamine amidotransferase of anthranilate synthase
Tsac_2020	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Tsac_2022	COG3599	regulation of cell shape
Tsac_2023	COG2302	S4 RNA-binding domain
Tsac_2025	COG1799	cell septum assembly
Tsac_2026	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Tsac_2031	COG0557	exoribonuclease II activity
Tsac_2038	COG0574	Belongs to the PEP-utilizing enzyme family
Tsac_2038	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Tsac_2039	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Tsac_2040	COG0423	glycine-tRNA ligase activity
Tsac_2044	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Tsac_2045	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Tsac_2046	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Tsac_2047	COG1480	7TM receptor with intracellular HD hydrolase
Tsac_2048	COG1702	phosphate starvation-inducible protein PhoH
Tsac_2051	COG1610	YqeY-like protein
Tsac_2052	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Tsac_2053	COG0537	adenosine 5'-monophosphoramidase activity
Tsac_2054	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tsac_2055	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Tsac_2056	COG2264	protein methyltransferase activity
Tsac_2057	COG0484	heat shock protein binding
Tsac_2058	COG0443	Heat shock 70 kDa protein
Tsac_2059	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Tsac_2061	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Tsac_2062	COG0481	GTPase activity
Tsac_2064	COG0438	transferase activity, transferring glycosyl groups
Tsac_2066	COG0860	N-Acetylmuramoyl-L-alanine amidase
Tsac_2068	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Tsac_2070	COG0268	Binds directly to 16S ribosomal RNA
Tsac_2072	COG0658	competence protein
Tsac_2072	COG2333	competence protein COMEC
Tsac_2077	COG1131	(ABC) transporter
Tsac_2082	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Tsac_2083	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Tsac_2085	COG0493	'glutamate synthase
Tsac_2088	COG1653	transport
Tsac_2089	COG0395	ABC-type sugar transport system, permease component
Tsac_2091	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
Tsac_2093	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Tsac_2094	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Tsac_2095	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Tsac_2097	COG1596	polysaccharide export
Tsac_2097	COG1555	photosystem II stabilization
Tsac_2098	COG1686	Belongs to the peptidase S11 family
Tsac_2099	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
Tsac_2100	COG2964	Protein conserved in bacteria
Tsac_2101	COG0799	negative regulation of ribosome biogenesis
Tsac_2102	COG1713	HD superfamily hydrolase involved in NAD metabolism
Tsac_2103	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Tsac_2104	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Tsac_2106	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Tsac_2108	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Tsac_2109	COG1530	ribonuclease E activity
Tsac_2112	COG1994	Peptidase M50
Tsac_2112	COG0517	IMP dehydrogenase activity
Tsac_2113	COG0739	heme binding
Tsac_2113	COG1388	LysM domain
Tsac_2115	COG0772	Belongs to the SEDS family
Tsac_2116	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Tsac_2117	COG2894	cell division
Tsac_2118	COG0850	regulation of cytokinetic process
Tsac_2122	COG1077	Cell shape determining protein MreB Mrl
Tsac_2123	COG2003	Belongs to the UPF0758 family
Tsac_2124	COG0424	maF-like protein
Tsac_2133	COG2878	Part of a membrane complex involved in electron transport
Tsac_2137	COG0741	lytic transglycosylase activity
Tsac_2139	COG0791	NLP P60 protein
Tsac_2142	COG2707	UPF0756 membrane protein
Tsac_2143	COG0741	lytic transglycosylase activity
Tsac_2144	COG0237	dephospho-CoA kinase activity
Tsac_2150	COG1113	amino acid transport
Tsac_2151	COG1983	PspC domain protein
Tsac_2152	COG3858	chitin binding
Tsac_2152	COG1388	LysM domain
Tsac_2155	COG2608	mercury ion transmembrane transporter activity
Tsac_2156	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Tsac_2157	COG4475	Protein of unknown function (DUF436)
Tsac_2158	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Tsac_2161	COG1013	pyruvate-flavodoxin oxidoreductase activity
Tsac_2162	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Tsac_2162	COG0674	pyruvate-flavodoxin oxidoreductase activity
Tsac_2164	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
Tsac_2166	COG0346	lactoylglutathione lyase activity
Tsac_2168	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Tsac_2168	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Tsac_2170	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Tsac_2173	COG0006	proline dipeptidase activity
Tsac_2174	COG0531	amino acid
Tsac_2181	COG3426	butyrate kinase activity
Tsac_2183	COG0280	phosphate acetyltransferase
Tsac_2187	COG2340	Cysteine-rich secretory protein family
Tsac_2188	COG1362	aminopeptidase activity
Tsac_2189	COG2197	response regulator
Tsac_2192	COG1193	negative regulation of DNA recombination
Tsac_2193	COG0826	peptidase U32
Tsac_2195	COG0072	phenylalanine-tRNA ligase activity
Tsac_2195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tsac_2196	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Tsac_2197	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Tsac_2198	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Tsac_2199	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Tsac_2200	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Tsac_2201	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Tsac_2203	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Tsac_2204	COG4399	Belongs to the UPF0754 family
Tsac_2204	COG4399	Belongs to the UPF0754 family
Tsac_2207	COG0745	RESPONSE REGULATOR receiver
Tsac_2210	COG0367	asparagine synthase
Tsac_2211	COG0840	transmembrane signaling receptor activity
Tsac_2212	COG0347	Belongs to the P(II) protein family
Tsac_2213	COG0004	ammonium transporteR
Tsac_2215	COG0004	ammonium transporteR
Tsac_2221	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
Tsac_2221	COG2508	Transcriptional regulator
Tsac_2223	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
Tsac_2225	COG4149	molybdate abc transporter
Tsac_2226	COG0725	ABC transporter, periplasmic molybdate-binding protein
Tsac_2228	COG0411	ABC transporter
Tsac_2230	COG0559	Belongs to the binding-protein-dependent transport system permease family
Tsac_2235	COG0347	Belongs to the P(II) protein family
Tsac_2236	COG0347	Belongs to the P(II) protein family
Tsac_2240	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Tsac_2241	COG1433	Dinitrogenase iron-molybdenum cofactor
Tsac_2241	COG0535	radical SAM domain protein
Tsac_2242	COG1433	Dinitrogenase iron-molybdenum cofactor
Tsac_2242	COG0535	radical SAM domain protein
Tsac_2245	COG0352	thiamine-phosphate diphosphorylase activity
Tsac_2248	COG0352	thiamine-phosphate diphosphorylase activity
Tsac_2248	COG0351	phosphomethylpyrimidine kinase
Tsac_2250	COG1132	(ABC) transporter
Tsac_2253	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
Tsac_2256	COG0395	ABC-type sugar transport system, permease component
Tsac_2257	COG1175	transmembrane transport
Tsac_2258	COG1653	transport
Tsac_2259	COG1609	Transcriptional regulator
Tsac_2261	COG0531	amino acid
Tsac_2262	COG0697	spore germination
Tsac_2263	COG5002	protein histidine kinase activity
Tsac_2269	COG1966	Carbon starvation protein
Tsac_2270	COG3279	Response regulator of the LytR AlgR family
Tsac_2271	COG3275	phosphorelay sensor kinase activity
Tsac_2277	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Tsac_2282	COG0514	ATP-dependent DNA helicase (RecQ)
Tsac_2283	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Tsac_2285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Tsac_2286	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
Tsac_2289	COG3525	Glycosyl hydrolase, family 20, catalytic domain
Tsac_2292	COG0445	tRNA wobble uridine modification
Tsac_2294	COG0395	ABC-type sugar transport system, permease component
Tsac_2296	COG1653	transport
Tsac_2297	COG1940	carbohydrate kinase activity
Tsac_2298	COG1737	Transcriptional regulator
Tsac_2299	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
Tsac_2301	COG3387	PFAM Glycoside hydrolase 15-related
Tsac_2302	COG0395	ABC-type sugar transport system, permease component
Tsac_2303	COG1175	transmembrane transport
Tsac_2314	COG3775	system Galactitol-specific IIC component
Tsac_2315	COG3414	Phosphotransferase system galactitol-specific IIB component
Tsac_2317	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Tsac_2317	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Tsac_2320	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Tsac_2321	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Tsac_2324	COG1175	transmembrane transport
Tsac_2326	COG1609	Transcriptional regulator
Tsac_2328	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Tsac_2329	COG2942	2-epimerase
Tsac_2330	COG1609	Transcriptional regulator
Tsac_2333	COG0346	lactoylglutathione lyase activity
Tsac_2336	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Tsac_2338	COG0569	domain protein
Tsac_2339	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Tsac_2342	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Tsac_2344	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Tsac_2345	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Tsac_2347	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Tsac_2349	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tsac_2350	COG0390	transport system, permease component
Tsac_2351	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Tsac_2352	COG2814	Major facilitator Superfamily
Tsac_2354	COG5002	protein histidine kinase activity
Tsac_2355	COG0745	RESPONSE REGULATOR receiver
Tsac_2357	COG1234	tRNA 3'-trailer cleavage
Tsac_2359	COG2894	cell division
Tsac_2360	COG0489	protein tyrosine kinase activity
Tsac_2362	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Tsac_2364	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Tsac_2370	COG0577	efflux transmembrane transporter activity
Tsac_2370	COG1136	(ABC) transporter
Tsac_2371	COG1136	(ABC) transporter
Tsac_2373	COG0772	Belongs to the SEDS family
Tsac_2374	COG0739	heme binding
Tsac_2375	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Tsac_2378	COG3773	Cell wall hydrolase
Tsac_2378	COG3409	Peptidoglycan-binding domain 1 protein
Tsac_2381	COG0586	Pfam SNARE associated Golgi protein
Tsac_2382	COG3706	GGDEF domain
Tsac_2383	COG0745	RESPONSE REGULATOR receiver
Tsac_2384	COG5002	protein histidine kinase activity
Tsac_2385	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Tsac_2386	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
Tsac_2387	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
Tsac_2388	COG2205	protein histidine kinase activity
Tsac_2391	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Tsac_2392	COG0367	asparagine synthase
Tsac_2397	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Tsac_2406	COG0497	DNA recombination
Tsac_2410	COG3757	hydrolase, family 25
Tsac_2410	COG3409	Peptidoglycan-binding domain 1 protein
Tsac_2453	COG1396	sequence-specific DNA binding
Tsac_2456	COG0582	viral genome integration into host DNA
Tsac_2457	COG1278	Cold shock
Tsac_2458	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Tsac_2461	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Tsac_2462	COG1902	pentaerythritol trinitrate reductase activity
Tsac_2464	COG1704	LemA family
Tsac_2465	COG1956	GAF domain-containing protein
Tsac_2466	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Tsac_2471	COG1482	cell wall glycoprotein biosynthetic process
Tsac_2472	COG0813	purine-nucleoside phosphorylase activity
Tsac_2473	COG0482	sulfurtransferase activity
Tsac_2474	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Tsac_2475	COG2384	SAM-dependent methyltransferase
Tsac_2476	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Tsac_2477	COG0358	DNA primase activity
Tsac_2478	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Tsac_2479	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Tsac_2480	COG1342	Belongs to the UPF0251 family
Tsac_2482	COG0148	phosphopyruvate hydratase activity
Tsac_2484	COG0149	triose-phosphate isomerase activity
Tsac_2485	COG0126	phosphoglycerate kinase activity
Tsac_2488	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Tsac_2489	COG1254	Belongs to the acylphosphatase family
Tsac_2490	COG0561	phosphatase activity
Tsac_2491	COG0735	belongs to the Fur family
Tsac_2492	COG2720	vancomycin resistance protein
Tsac_2494	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Tsac_2495	COG1067	ATP-dependent peptidase activity
Tsac_2501	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Tsac_2503	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Tsac_2504	COG3716	PTS system mannose fructose sorbose family IID component
Tsac_2506	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Tsac_2506	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tsac_2507	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Tsac_2507	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Tsac_2508	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Tsac_2509	COG1773	rubredoxin
Tsac_2509	COG1592	Rubrerythrin
Tsac_2523	COG0564	pseudouridine synthase activity
Tsac_2527	COG0210	DNA helicase
Tsac_2529	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Tsac_2530	COG1131	(ABC) transporter
Tsac_2534	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
Tsac_2536	COG0778	Nitroreductase
Tsac_2538	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Tsac_2540	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Tsac_2541	COG1511	domain protein
Tsac_2542	COG1309	transcriptional regulator
Tsac_2544	COG0457	Tetratricopeptide repeat
Tsac_2544	COG0463	Glycosyl transferase, family 2
Tsac_2547	COG0730	response to heat
Tsac_2548	COG1132	(ABC) transporter
Tsac_2551	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Tsac_2552	COG0860	N-Acetylmuramoyl-L-alanine amidase
Tsac_2553	COG4608	Belongs to the ABC transporter superfamily
Tsac_2554	COG0444	Belongs to the ABC transporter superfamily
Tsac_2555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Tsac_2556	COG0601	transmembrane transport
Tsac_2557	COG4166	transmembrane transport
Tsac_2558	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Tsac_2560	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Tsac_2563	COG4496	protein, YerC YecD
Tsac_2564	COG1447	Phosphotransferase system cellobiose-specific component IIA
Tsac_2565	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Tsac_2568	COG3711	transcriptional antiterminator
Tsac_2569	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Tsac_2570	COG2011	ABC-type metal ion transport system permease component
Tsac_2573	COG1854	S-ribosylhomocysteine lyase activity
Tsac_2575	COG1473	amidohydrolase
Tsac_2576	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Tsac_2577	COG0151	Belongs to the GarS family
Tsac_2578	COG0138	bifunctional purine biosynthesis protein purh
Tsac_2580	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Tsac_2581	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Tsac_2582	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Tsac_2583	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Tsac_2584	COG2252	PERMEase
Tsac_2587	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Tsac_2587	COG0519	Catalyzes the synthesis of GMP from XMP
Tsac_2588	COG0516	GMP reductase activity
Tsac_2588	COG0517	IMP dehydrogenase activity
Tsac_2589	COG0459	protein refolding
Tsac_2597	COG1404	Belongs to the peptidase S8 family
Tsac_2599	COG1136	(ABC) transporter
Tsac_2600	COG4120	Belongs to the binding-protein-dependent transport system permease family
Tsac_2603	COG0559	Belongs to the binding-protein-dependent transport system permease family
Tsac_2605	COG0411	ABC transporter
Tsac_2608	COG1811	Na channel or pump
Tsac_2614	COG1914	H( )-stimulated, divalent metal cation uptake system
Tsac_2616	COG1360	Flagellar Motor Protein
Tsac_2618	COG0488	(ABC) transporter
Tsac_2620	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Tsac_2621	COG0456	acetyltransferase
Tsac_2622	COG1214	PFAM Peptidase M22, glycoprotease
Tsac_2623	COG0802	atpase or kinase
Tsac_2626	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Tsac_2628	COG0398	Pfam SNARE associated Golgi protein
Tsac_2629	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Tsac_2630	COG2183	response to ionizing radiation
Tsac_2631	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Tsac_2632	COG0653	protein targeting
Tsac_2633	COG1122	ATPase activity
Tsac_2634	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Tsac_2636	COG0310	cobalt ion transport
Tsac_2637	COG2099	Precorrin-6x reductase
Tsac_2640	COG2875	Belongs to the precorrin methyltransferase family
Tsac_2642	COG2242	protein methyltransferase activity
Tsac_2643	COG2241	protein methyltransferase activity
Tsac_2648	COG1827	regulation of RNA biosynthetic process
Tsac_2653	COG1126	abc transporter atp-binding protein
Tsac_2654	COG0765	amino acid transport
Tsac_2655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Tsac_2658	COG1516	flagellar protein fliS
Tsac_2659	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Tsac_2666	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Tsac_2667	COG0110	maltose O-acetyltransferase activity
Tsac_2668	COG2089	acid synthase
Tsac_2669	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Tsac_2670	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Tsac_2671	COG1086	Polysaccharide biosynthesis protein
Tsac_2672	COG2604	Protein of unknown function DUF115
Tsac_2674	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Tsac_2675	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Tsac_2676	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
Tsac_2678	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Tsac_2679	COG1256	bacterial-type flagellum assembly
Tsac_2679	COG4786	Flagellar basal body rod
Tsac_2683	COG1040	competence protein
Tsac_2684	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Tsac_2689	COG0617	tRNA 3'-terminal CCA addition
Tsac_2708	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Tsac_2713	COG3547	Transposase (IS116 IS110 IS902 family)
Tsac_2727	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Tsac_2743	COG1690	Belongs to the RtcB family
Tsac_2748	COG4581	dead DEAH box helicase
Tsac_2752	COG2314	TM2 domain
Tsac_2762	COG0539	negative regulation of cytoplasmic translation
Tsac_2780	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Tsac_2780	COG2199	diguanylate cyclase activity
Tsac_2795	COG0756	dUTP diphosphatase activity
Tsac_2805	COG0776	regulation of translation
Tsac_2813	COG0629	single-stranded DNA binding
Tsac_2815	COG0592	DNA-directed DNA polymerase activity
Tsac_2824	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Tsac_2862	COG1783	phage Terminase large subunit