locus-tag	class	description
Tthe_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Tthe_0002	COG0592	DNA-directed DNA polymerase activity
Tthe_0003	COG2501	S4 domain
Tthe_0008	COG0187	DNA topoisomerase II activity
Tthe_0009	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Tthe_0012	COG0440	acetolactate synthase activity
Tthe_0013	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Tthe_0014	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Tthe_0015	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Tthe_0016	COG0066	3-isopropylmalate dehydratase activity
Tthe_0017	COG0473	3-isopropylmalate dehydrogenase activity
Tthe_0018	COG0129	dihydroxy-acid dehydratase activity
Tthe_0019	COG0028	Belongs to the TPP enzyme family
Tthe_0027	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Tthe_0029	COG1316	TRANSCRIPTIONal
Tthe_0030	COG1615	UPF0182 protein
Tthe_0035	COG0641	radical SAM
Tthe_0047	COG0590	tRNA wobble adenosine to inosine editing
Tthe_0049	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Tthe_0049	COG2199	diguanylate cyclase activity
Tthe_0050	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Tthe_0052	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Tthe_0054	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Tthe_0056	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Tthe_0061	COG1028	Short-chain dehydrogenase reductase Sdr
Tthe_0062	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Tthe_0065	COG1187	pseudouridine synthase activity
Tthe_0067	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Tthe_0068	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tthe_0069	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Tthe_0071	COG1573	uracil-dna glycosylase
Tthe_0072	COG1940	carbohydrate kinase activity
Tthe_0073	COG0519	Catalyzes the synthesis of GMP from XMP
Tthe_0076	COG1982	Orn Lys Arg decarboxylase major
Tthe_0077	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Tthe_0078	COG3870	Protein conserved in bacteria
Tthe_0081	COG1774	PSP1 C-terminal conserved region
Tthe_0083	COG0730	response to heat
Tthe_0086	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Tthe_0087	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Tthe_0088	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Tthe_0089	COG2002	toxin-antitoxin pair type II binding
Tthe_0090	COG2715	membrane protein required for spore maturation
Tthe_0091	COG0700	Nucleoside recognition
Tthe_0093	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tthe_0093	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tthe_0094	COG1725	Transcriptional regulator
Tthe_0095	COG1131	(ABC) transporter
Tthe_0104	COG3063	Type IV pilus biogenesis stability protein PilW
Tthe_0107	COG0084	hydrolase, TatD family'
Tthe_0109	COG3583	domain protein
Tthe_0109	COG3584	3D domain protein
Tthe_0110	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Tthe_0114	COG0489	protein tyrosine kinase activity
Tthe_0118	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Tthe_0118	COG2111	Na H antiporter
Tthe_0120	COG3260	NADH ubiquinone oxidoreductase 20
Tthe_0123	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tthe_0124	COG0375	protein maturation
Tthe_0126	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Tthe_0127	COG0298	carbon dioxide binding
Tthe_0128	COG0409	Hydrogenase expression formation protein
Tthe_0129	COG0309	Hydrogenase expression formation protein (HypE)
Tthe_0130	COG3409	Peptidoglycan-binding domain 1 protein
Tthe_0130	COG3773	Cell wall hydrolase
Tthe_0136	COG1175	transmembrane transport
Tthe_0137	COG3833	ABC-type maltose transport systems, permease component
Tthe_0138	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Tthe_0142	COG1131	(ABC) transporter
Tthe_0144	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Tthe_0146	COG2221	Nitrite and sulphite reductase 4Fe-4S
Tthe_0170	COG0789	Transcriptional regulator
Tthe_0171	COG1664	Polymer-forming cytoskeletal
Tthe_0173	COG0071	Belongs to the small heat shock protein (HSP20) family
Tthe_0188	COG0071	Belongs to the small heat shock protein (HSP20) family
Tthe_0190	COG1609	Transcriptional regulator
Tthe_0191	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Tthe_0192	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Tthe_0194	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Tthe_0195	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Tthe_0197	COG5002	protein histidine kinase activity
Tthe_0197	COG3850	Histidine kinase
Tthe_0198	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tthe_0201	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Tthe_0202	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Tthe_0203	COG2002	toxin-antitoxin pair type II binding
Tthe_0205	COG4466	Protein conserved in bacteria
Tthe_0207	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Tthe_0208	COG1802	Transcriptional regulator
Tthe_0211	COG0697	spore germination
Tthe_0212	COG0531	amino acid
Tthe_0215	COG1982	Orn Lys Arg decarboxylase major
Tthe_0216	COG3773	Cell wall hydrolase
Tthe_0216	COG3409	Peptidoglycan-binding domain 1 protein
Tthe_0217	COG2959	enzyme of heme biosynthesis
Tthe_0219	COG1181	Belongs to the D-alanine--D-alanine ligase family
Tthe_0221	COG0018	arginyl-trna synthetase
Tthe_0222	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Tthe_0223	COG1131	(ABC) transporter
Tthe_0225	COG0531	amino acid
Tthe_0227	COG0667	Aldo Keto reductase
Tthe_0229	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Tthe_0230	COG3859	Proton-coupled thiamine transporter YuaJ
Tthe_0232	COG0671	phosphoesterase, PA-phosphatase related
Tthe_0235	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Tthe_0240	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Tthe_0241	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Tthe_0243	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Tthe_0244	COG0505	Belongs to the CarA family
Tthe_0245	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Tthe_0247	COG0165	Argininosuccinate lyase
Tthe_0249	COG0446	pyridine nucleotide-disulphide oxidoreductase
Tthe_0250	COG0586	Pfam SNARE associated Golgi protein
Tthe_0254	COG2033	superoxide reductase activity
Tthe_0255	COG1027	Aspartate ammonia-lyase
Tthe_0257	COG2211	Major facilitator Superfamily
Tthe_0259	COG3956	TIGRFAM MazG family protein
Tthe_0260	COG0776	regulation of translation
Tthe_0261	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Tthe_0262	COG2385	sporulation resulting in formation of a cellular spore
Tthe_0268	COG1098	S1 RNA binding domain
Tthe_0269	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Tthe_0269	COG0248	Ppx GppA phosphatase
Tthe_0272	COG1396	sequence-specific DNA binding
Tthe_0281	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
Tthe_0305	COG0739	heme binding
Tthe_0322	COG0840	transmembrane signaling receptor activity
Tthe_0327	COG0653	protein targeting
Tthe_0330	COG0860	N-Acetylmuramoyl-L-alanine amidase
Tthe_0332	COG2233	PERMEase
Tthe_0335	COG1131	(ABC) transporter
Tthe_0337	COG1309	transcriptional regulator
Tthe_0338	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Tthe_0338	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Tthe_0338	COG0674	pyruvate-flavodoxin oxidoreductase activity
Tthe_0338	COG1013	pyruvate-flavodoxin oxidoreductase activity
Tthe_0344	COG1131	(ABC) transporter
Tthe_0346	COG1595	DNA-templated transcription, initiation
Tthe_0350	COG3830	Belongs to the UPF0237 family
Tthe_0352	COG2226	methyltransferase
Tthe_0356	COG2208	phosphoserine phosphatase activity
Tthe_0359	COG0037	tRNA processing
Tthe_0364	COG5002	protein histidine kinase activity
Tthe_0367	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Tthe_0369	COG4770	biotin carboxylase activity
Tthe_0370	COG4684	Psort location CytoplasmicMembrane, score
Tthe_0371	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Tthe_0373	COG0697	spore germination
Tthe_0378	COG5322	oxidoreductase activity
Tthe_0378	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Tthe_0379	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Tthe_0380	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Tthe_0381	COG0302	gtp cyclohydrolase
Tthe_0382	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Tthe_0383	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Tthe_0384	COG0720	synthase
Tthe_0385	COG1489	DNA binding
Tthe_0386	COG4224	UPF0291 protein
Tthe_0390	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Tthe_0391	COG2203	Gaf domain
Tthe_0391	COG2199	diguanylate cyclase activity
Tthe_0393	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Tthe_0394	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Tthe_0395	COG0281	malic enzyme
Tthe_0398	COG3880	PFAM UvrB UvrC protein
Tthe_0399	COG3869	Catalyzes the specific phosphorylation of arginine residues in
Tthe_0400	COG0542	response to heat
Tthe_0401	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Tthe_0403	COG4956	integral membrane protein (PIN domain superfamily)
Tthe_0404	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Tthe_0406	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Tthe_0409	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Tthe_0410	COG1045	serine acetyltransferase
Tthe_0411	COG0215	cysteine-tRNA ligase activity
Tthe_0413	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Tthe_0414	COG3688	RNA-binding protein containing a PIN domain
Tthe_0415	COG1595	DNA-templated transcription, initiation
Tthe_0416	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Tthe_0418	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Tthe_0419	COG0250	Participates in transcription elongation, termination and antitermination
Tthe_0420	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Tthe_0423	COG0222	ribosome binding
Tthe_0424	COG0085	RNA polymerase activity
Tthe_0425	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Tthe_0426	COG1358	cellular component organization or biogenesis
Tthe_0427	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Tthe_0428	COG0049	tRNA binding
Tthe_0429	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Tthe_0430	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Tthe_0431	COG0051	transcription antitermination factor activity, RNA binding
Tthe_0432	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Tthe_0433	COG0088	Forms part of the polypeptide exit tunnel
Tthe_0434	COG0089	rRNA binding
Tthe_0435	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Tthe_0436	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Tthe_0437	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Tthe_0438	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Tthe_0439	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Tthe_0440	COG0255	Belongs to the universal ribosomal protein uL29 family
Tthe_0441	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Tthe_0442	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Tthe_0443	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Tthe_0444	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Tthe_0446	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Tthe_0447	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Tthe_0448	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Tthe_0449	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Tthe_0450	COG1841	ribosomal large subunit assembly
Tthe_0451	COG0200	Binds to the 23S rRNA
Tthe_0452	COG0201	protein transport
Tthe_0453	COG0563	adenylate kinase activity
Tthe_0456	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Tthe_0457	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Tthe_0458	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Tthe_0459	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Tthe_0460	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Tthe_0461	COG0202	RNA polymerase activity
Tthe_0462	COG0203	ribosomal protein L17
Tthe_0463	COG1122	ATPase activity
Tthe_0464	COG1122	ATPase activity
Tthe_0465	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Tthe_0466	COG0101	tRNA pseudouridine synthase activity
Tthe_0467	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Tthe_0468	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Tthe_0470	COG1136	(ABC) transporter
Tthe_0471	COG0577	efflux transmembrane transporter activity
Tthe_0471	COG1136	(ABC) transporter
Tthe_0472	COG1454	alcohol dehydrogenase
Tthe_0480	COG0714	Associated with various cellular activities
Tthe_0481	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
Tthe_0482	COG1305	Transglutaminase-like
Tthe_0484	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
Tthe_0492	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Tthe_0494	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Tthe_0504	COG1397	ADP-ribosylglycohydrolase
Tthe_0506	COG1396	sequence-specific DNA binding
Tthe_0526	COG0454	-acetyltransferase
Tthe_0528	COG0561	phosphatase activity
Tthe_0529	COG2703	oxygen carrier activity
Tthe_0531	COG3973	AAA domain
Tthe_0532	COG0432	Pfam Uncharacterised protein family UPF0047
Tthe_0535	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Tthe_0535	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Tthe_0537	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Tthe_0539	COG2337	Toxic component of a toxin-antitoxin (TA) module
Tthe_0543	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
Tthe_0546	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Tthe_0547	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Tthe_0549	COG1773	rubredoxin
Tthe_0550	COG0673	inositol 2-dehydrogenase activity
Tthe_0551	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
Tthe_0551	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Tthe_0552	COG3459	Glycosyltransferase 36 associated
Tthe_0553	COG1725	Transcriptional regulator
Tthe_0555	COG4377	Putative membrane peptidase family (DUF2324)
Tthe_0556	COG0330	HflC and HflK could
Tthe_0558	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Tthe_0559	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Tthe_0560	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Tthe_0562	COG0131	Imidazoleglycerol-phosphate dehydratase
Tthe_0563	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Tthe_0566	COG0140	phosphoribosyl-ATP diphosphatase activity
Tthe_0566	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Tthe_0567	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Tthe_0569	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Tthe_0570	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
Tthe_0572	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Tthe_0577	COG0640	Transcriptional regulator
Tthe_0581	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Tthe_0582	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Tthe_0583	COG0640	Transcriptional regulator
Tthe_0585	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Tthe_0586	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Tthe_0587	COG0579	oxidoreductase
Tthe_0588	COG0492	ferredoxin-NADP+ reductase activity
Tthe_0590	COG3290	protein histidine kinase activity
Tthe_0590	COG3829	transcription factor binding
Tthe_0591	COG2376	Dihydroxyacetone kinase
Tthe_0593	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
Tthe_0602	COG0849	cell division
Tthe_0607	COG1131	(ABC) transporter
Tthe_0609	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Tthe_0613	COG3842	ATPase activity
Tthe_0615	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Tthe_0616	COG0437	4 iron, 4 sulfur cluster binding
Tthe_0617	COG0069	glutamate synthase activity
Tthe_0618	COG0067	glutamate synthase
Tthe_0619	COG3835	regulator
Tthe_0620	COG2884	Cell division ATP-binding protein ftsE
Tthe_0621	COG2177	Part of the ABC transporter FtsEX involved in
Tthe_0622	COG0739	heme binding
Tthe_0623	COG0793	Belongs to the peptidase S41A family
Tthe_0624	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tthe_0625	COG2045	Belongs to the ComB family
Tthe_0626	COG0556	nucleotide-excision repair
Tthe_0628	COG1716	ATPase activity
Tthe_0630	COG0768	penicillin binding
Tthe_0632	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Tthe_0632	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Tthe_0633	COG3711	transcriptional antiterminator
Tthe_0634	COG1263	PTS System
Tthe_0634	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Tthe_0634	COG2190	(PTS) system
Tthe_0636	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Tthe_0638	COG1940	carbohydrate kinase activity
Tthe_0639	COG0318	PFAM AMP-dependent synthetase and ligase
Tthe_0641	COG0673	inositol 2-dehydrogenase activity
Tthe_0644	COG0673	inositol 2-dehydrogenase activity
Tthe_0645	COG3250	beta-galactosidase activity
Tthe_0646	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Tthe_0646	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Tthe_0647	COG1447	Phosphotransferase system cellobiose-specific component IIA
Tthe_0648	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
Tthe_0650	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Tthe_0652	COG2723	6-phospho-beta-galactosidase activity
Tthe_0654	COG1874	Beta-galactosidase
Tthe_0655	COG1501	Belongs to the glycosyl hydrolase 31 family
Tthe_0656	COG3534	alpha-L-arabinofuranosidase
Tthe_0658	COG4209	transmembrane transport
Tthe_0659	COG0395	ABC-type sugar transport system, permease component
Tthe_0665	COG3507	Belongs to the glycosyl hydrolase 43 family
Tthe_0666	COG2160	L-arabinose isomerase activity
Tthe_0667	COG1069	ribulokinase activity
Tthe_0668	COG0235	Class ii aldolase
Tthe_0670	COG1609	Transcriptional regulator
Tthe_0671	COG0371	Dehydrogenase
Tthe_0677	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
Tthe_0678	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Tthe_0679	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Tthe_0680	COG1940	carbohydrate kinase activity
Tthe_0681	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tthe_0701	COG1477	protein flavinylation
Tthe_0703	COG0768	penicillin binding
Tthe_0704	COG1793	dna ligase
Tthe_0704	COG3285	dna ligase
Tthe_0705	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
Tthe_0706	COG0791	NLP P60 protein
Tthe_0706	COG1388	LysM domain
Tthe_0707	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Tthe_0710	COG2755	lipolytic protein G-D-S-L family
Tthe_0710	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Tthe_0711	COG0531	amino acid
Tthe_0716	COG2608	mercury ion transmembrane transporter activity
Tthe_0718	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Tthe_0719	COG1193	negative regulation of DNA recombination
Tthe_0720	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Tthe_0720	COG1796	DNA polymerase
Tthe_0721	COG2226	methyltransferase
Tthe_0722	COG0626	cystathionine gamma-synthase activity
Tthe_0723	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Tthe_0726	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Tthe_0728	COG4942	peptidase
Tthe_0732	COG1914	H( )-stimulated, divalent metal cation uptake system
Tthe_0734	COG2226	methyltransferase
Tthe_0736	COG0785	Cytochrome C biogenesis protein
Tthe_0740	COG5002	protein histidine kinase activity
Tthe_0741	COG2204	response regulator
Tthe_0745	COG2217	Heavy metal translocating P-type atpase
Tthe_0747	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Tthe_0749	COG1660	Displays ATPase and GTPase activities
Tthe_0754	COG1653	transport
Tthe_0758	COG1175	transmembrane transport
Tthe_0759	COG3833	ABC-type maltose transport systems, permease component
Tthe_0762	COG1426	Protein conserved in bacteria
Tthe_0763	COG0366	Alpha amylase catalytic
Tthe_0765	COG1481	regulation of sporulation
Tthe_0766	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tthe_0767	COG4109	DRTGG domain
Tthe_0770	COG0205	6-phosphofructokinase activity
Tthe_0774	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Tthe_0779	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Tthe_0791	COG4695	Portal protein
Tthe_0792	COG0740	serine-type endopeptidase activity
Tthe_0810	COG3409	Peptidoglycan-binding domain 1 protein
Tthe_0810	COG5632	N-Acetylmuramoyl-L-alanine amidase
Tthe_0811	COG1388	LysM domain
Tthe_0811	COG0791	NLP P60 protein
Tthe_0815	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Tthe_0818	COG2217	Heavy metal translocating P-type atpase
Tthe_0825	COG0778	Nitroreductase
Tthe_0830	COG1199	ATP-dependent helicase activity
Tthe_0832	COG3064	Membrane
Tthe_0832	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
Tthe_0832	COG1073	alpha beta
Tthe_0833	COG2195	Cleaves the N-terminal amino acid of tripeptides
Tthe_0834	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Tthe_0835	COG0778	Nitroreductase
Tthe_0840	COG4656	Part of a membrane complex involved in electron transport
Tthe_0841	COG4658	electron transport chain
Tthe_0842	COG4659	FMN binding
Tthe_0843	COG4660	Part of a membrane complex involved in electron transport
Tthe_0844	COG4657	Part of a membrane complex involved in electron transport
Tthe_0845	COG1245	4Fe-4S binding domain
Tthe_0845	COG2878	Part of a membrane complex involved in electron transport
Tthe_0848	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Tthe_0848	COG0646	methionine synthase
Tthe_0849	COG1410	methionine synthase
Tthe_0849	COG0646	methionine synthase
Tthe_0850	COG3546	catalase activity
Tthe_0853	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Tthe_0867	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
Tthe_0870	COG0667	Aldo Keto reductase
Tthe_0875	COG0789	Transcriptional regulator
Tthe_0879	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Tthe_0880	COG1234	tRNA 3'-trailer cleavage
Tthe_0881	COG0544	peptidyl-prolyl cis-trans isomerase activity
Tthe_0882	COG0740	serine-type endopeptidase activity
Tthe_0883	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Tthe_0885	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Tthe_0886	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Tthe_0887	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Tthe_0888	COG0569	domain protein
Tthe_0889	COG0356	it plays a direct role in the translocation of protons across the membrane
Tthe_0890	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Tthe_0891	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Tthe_0892	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Tthe_0893	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Tthe_0894	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Tthe_0895	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Tthe_0896	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Tthe_0899	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Tthe_0899	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Tthe_0900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Tthe_0901	COG1116	anion transmembrane transporter activity
Tthe_0902	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Tthe_0904	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Tthe_0905	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
Tthe_0917	COG0438	transferase activity, transferring glycosyl groups
Tthe_0923	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Tthe_0924	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Tthe_0927	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tthe_0950	COG1201	RNA secondary structure unwinding
Tthe_0968	COG2221	Nitrite and sulphite reductase 4Fe-4S
Tthe_0971	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Tthe_0974	COG1802	Transcriptional regulator
Tthe_0976	COG4209	transmembrane transport
Tthe_0977	COG0395	ABC-type sugar transport system, permease component
Tthe_0980	COG0673	inositol 2-dehydrogenase activity
Tthe_0983	COG3664	PFAM glycoside hydrolase family 39
Tthe_0984	COG3458	cephalosporin-C deacetylase activity
Tthe_0986	COG3275	phosphorelay sensor kinase activity
Tthe_0990	COG4209	transmembrane transport
Tthe_0991	COG0395	ABC-type sugar transport system, permease component
Tthe_0995	COG1653	transport
Tthe_0996	COG1175	transmembrane transport
Tthe_0997	COG0395	ABC-type sugar transport system, permease component
Tthe_1010	COG1942	4-Oxalocrotonate Tautomerase
Tthe_1015	COG5464	transposase or invertase
Tthe_1018	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Tthe_1020	COG1316	TRANSCRIPTIONal
Tthe_1021	COG3949	Membrane
Tthe_1023	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Tthe_1025	COG0105	UTP biosynthetic process
Tthe_1029	COG0426	domain, Protein
Tthe_1030	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Tthe_1031	COG0671	phosphoesterase, PA-phosphatase related
Tthe_1033	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Tthe_1034	COG1606	tRNA processing
Tthe_1035	COG1691	(AIR) carboxylase
Tthe_1036	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Tthe_1037	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Tthe_1038	COG1268	BioY protein
Tthe_1039	COG0525	valine-tRNA ligase activity
Tthe_1041	COG0285	dihydrofolate synthase activity
Tthe_1047	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Tthe_1054	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Tthe_1055	COG0726	polysaccharide deacetylase
Tthe_1058	COG2171	N-acyltransferase activity
Tthe_1059	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Tthe_1060	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Tthe_1061	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Tthe_1065	COG0745	RESPONSE REGULATOR receiver
Tthe_1065	COG3706	GGDEF domain
Tthe_1066	COG1181	Belongs to the D-alanine--D-alanine ligase family
Tthe_1068	COG1252	NADH dehydrogenase
Tthe_1071	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Tthe_1072	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Tthe_1075	COG3858	chitin binding
Tthe_1077	COG0739	heme binding
Tthe_1078	COG0438	transferase activity, transferring glycosyl groups
Tthe_1088	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Tthe_1089	COG4475	Protein of unknown function (DUF436)
Tthe_1091	COG2217	Heavy metal translocating P-type atpase
Tthe_1092	COG2217	Heavy metal translocating P-type atpase
Tthe_1094	COG1388	LysM domain
Tthe_1094	COG3858	chitin binding
Tthe_1095	COG1983	PspC domain protein
Tthe_1096	COG1113	amino acid transport
Tthe_1098	COG1376	ErfK ybiS ycfS ynhG family protein
Tthe_1099	COG1595	DNA-templated transcription, initiation
Tthe_1102	COG0237	dephospho-CoA kinase activity
Tthe_1103	COG0741	lytic transglycosylase activity
Tthe_1104	COG2707	UPF0756 membrane protein
Tthe_1107	COG0791	NLP P60 protein
Tthe_1109	COG0741	lytic transglycosylase activity
Tthe_1113	COG2878	Part of a membrane complex involved in electron transport
Tthe_1117	COG3290	protein histidine kinase activity
Tthe_1122	COG0424	maF-like protein
Tthe_1123	COG2003	Belongs to the UPF0758 family
Tthe_1124	COG1077	Cell shape determining protein MreB Mrl
Tthe_1128	COG0850	regulation of cytokinetic process
Tthe_1129	COG2894	cell division
Tthe_1130	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Tthe_1131	COG0772	Belongs to the SEDS family
Tthe_1133	COG1388	LysM domain
Tthe_1133	COG0739	heme binding
Tthe_1134	COG0517	IMP dehydrogenase activity
Tthe_1134	COG1994	Peptidase M50
Tthe_1137	COG1530	ribonuclease E activity
Tthe_1138	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Tthe_1140	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Tthe_1142	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Tthe_1143	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Tthe_1144	COG1713	HD superfamily hydrolase involved in NAD metabolism
Tthe_1145	COG0799	negative regulation of ribosome biogenesis
Tthe_1146	COG2964	Protein conserved in bacteria
Tthe_1147	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
Tthe_1148	COG1686	Belongs to the peptidase S11 family
Tthe_1149	COG1555	photosystem II stabilization
Tthe_1149	COG1596	polysaccharide export
Tthe_1151	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Tthe_1152	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Tthe_1153	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Tthe_1158	COG0493	'glutamate synthase
Tthe_1160	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Tthe_1166	COG1131	(ABC) transporter
Tthe_1167	COG1846	Transcriptional regulator
Tthe_1170	COG1234	tRNA 3'-trailer cleavage
Tthe_1171	COG2333	competence protein COMEC
Tthe_1171	COG0658	competence protein
Tthe_1173	COG0268	Binds directly to 16S ribosomal RNA
Tthe_1175	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Tthe_1181	COG0481	GTPase activity
Tthe_1182	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Tthe_1184	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Tthe_1186	COG0443	Heat shock 70 kDa protein
Tthe_1187	COG0484	heat shock protein binding
Tthe_1188	COG2264	protein methyltransferase activity
Tthe_1189	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Tthe_1190	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tthe_1191	COG0537	adenosine 5'-monophosphoramidase activity
Tthe_1192	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Tthe_1193	COG1610	YqeY-like protein
Tthe_1196	COG1702	phosphate starvation-inducible protein PhoH
Tthe_1197	COG1480	7TM receptor with intracellular HD hydrolase
Tthe_1198	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Tthe_1199	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Tthe_1200	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Tthe_1204	COG0423	glycine-tRNA ligase activity
Tthe_1205	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Tthe_1206	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Tthe_1206	COG0574	Belongs to the PEP-utilizing enzyme family
Tthe_1209	COG0557	exoribonuclease II activity
Tthe_1216	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Tthe_1217	COG1799	cell septum assembly
Tthe_1219	COG2302	S4 RNA-binding domain
Tthe_1220	COG3599	regulation of cell shape
Tthe_1222	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Tthe_1223	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Tthe_1226	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Tthe_1226	COG0512	Glutamine amidotransferase of anthranilate synthase
Tthe_1227	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Tthe_1228	COG0134	indole-3-glycerol-phosphate synthase activity
Tthe_1229	COG0135	phosphoribosylanthranilate isomerase activity
Tthe_1232	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Tthe_1243	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Tthe_1245	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Tthe_1246	COG0564	pseudouridine synthase activity
Tthe_1249	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Tthe_1250	COG1937	Protein conserved in bacteria
Tthe_1251	COG3118	belongs to the thioredoxin family
Tthe_1253	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Tthe_1254	COG1959	2 iron, 2 sulfur cluster binding
Tthe_1261	COG0628	permease
Tthe_1262	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Tthe_1263	COG4472	Bacterial protein of unknown function (DUF965)
Tthe_1265	COG3906	Belongs to the UPF0473 family
Tthe_1266	COG0735	belongs to the Fur family
Tthe_1267	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Tthe_1268	COG3679	Belongs to the UPF0342 family
Tthe_1269	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Tthe_1272	COG0768	penicillin binding
Tthe_1273	COG1191	sigma factor activity
Tthe_1274	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Tthe_1276	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Tthe_1281	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Tthe_1291	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Tthe_1292	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Tthe_1293	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Tthe_1294	COG0006	proline dipeptidase activity
Tthe_1295	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Tthe_1297	COG3854	ATPases associated with a variety of cellular activities
Tthe_1305	COG1302	Protein conserved in bacteria
Tthe_1308	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Tthe_1309	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Tthe_1310	COG1570	exodeoxyribonuclease VII activity
Tthe_1311	COG1722	exodeoxyribonuclease VII activity
Tthe_1312	COG0142	geranyltranstransferase activity
Tthe_1314	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Tthe_1315	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Tthe_1316	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Tthe_1317	COG1438	arginine binding
Tthe_1318	COG0497	DNA recombination
Tthe_1319	COG0750	zinc metalloprotease
Tthe_1327	COG0494	nUDIX hydrolase
Tthe_1328	COG1379	DNA repair
Tthe_1329	COG1300	Membrane
Tthe_1330	COG4974	Belongs to the 'phage' integrase family
Tthe_1331	COG1686	Belongs to the peptidase S11 family
Tthe_1333	COG2172	sigma factor antagonist activity
Tthe_1335	COG3360	Dodecin
Tthe_1339	COG0617	tRNA 3'-terminal CCA addition
Tthe_1340	COG1994	Peptidase M50
Tthe_1341	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Tthe_1342	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Tthe_1344	COG3874	Sporulation protein YtfJ
Tthe_1345	COG1686	Belongs to the peptidase S11 family
Tthe_1347	COG0445	tRNA wobble uridine modification
Tthe_1348	COG1187	pseudouridine synthase activity
Tthe_1350	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Tthe_1351	COG0010	Belongs to the arginase family
Tthe_1353	COG1388	LysM domain
Tthe_1355	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Tthe_1357	COG0406	alpha-ribazole phosphatase activity
Tthe_1358	COG2081	HI0933 family
Tthe_1360	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Tthe_1362	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Tthe_1364	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Tthe_1365	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Tthe_1368	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Tthe_1369	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Tthe_1370	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Tthe_1371	COG1923	regulation of RNA biosynthetic process
Tthe_1372	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Tthe_1373	COG0328	RNA-DNA hybrid ribonuclease activity
Tthe_1374	COG4974	Belongs to the 'phage' integrase family
Tthe_1375	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Tthe_1376	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
Tthe_1377	COG0464	growth
Tthe_1378	COG0017	Asparaginyl-tRNA synthetase
Tthe_1379	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Tthe_1381	COG0613	PHP domain protein
Tthe_1382	COG2359	stage V sporulation protein S
Tthe_1383	COG1692	metallophosphoesterase
Tthe_1384	COG1418	mRNA catabolic process
Tthe_1385	COG0419	ATPase involved in DNA repair
Tthe_1386	COG0420	3'-5' exonuclease activity
Tthe_1391	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Tthe_1392	COG1058	Belongs to the CinA family
Tthe_1392	COG1546	Belongs to the CinA family
Tthe_1393	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Tthe_1394	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tthe_1395	COG1674	ftsk spoiiie
Tthe_1397	COG0740	serine-type endopeptidase activity
Tthe_1398	COG0527	aspartate kinase activity
Tthe_1400	COG0756	dUTP diphosphatase activity
Tthe_1401	COG0612	Peptidase, M16
Tthe_1402	COG0726	polysaccharide deacetylase
Tthe_1403	COG1185	polyribonucleotide nucleotidyltransferase activity
Tthe_1404	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Tthe_1405	COG0196	riboflavin kinase activity
Tthe_1406	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Tthe_1407	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Tthe_1408	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Tthe_1411	COG2740	Nucleic-acid-binding protein implicated in transcription termination
Tthe_1412	COG0195	Participates in both transcription termination and antitermination
Tthe_1413	COG0779	Required for maturation of 30S ribosomal subunits
Tthe_1414	COG2176	DNA-directed DNA polymerase activity
Tthe_1416	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Tthe_1417	COG0750	zinc metalloprotease
Tthe_1418	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Tthe_1419	COG4589	Belongs to the CDS family
Tthe_1420	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Tthe_1422	COG0233	cytoplasmic translational termination
Tthe_1423	COG0528	UMP kinase activity
Tthe_1424	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Tthe_1425	COG0052	Belongs to the universal ribosomal protein uS2 family
Tthe_1428	COG1191	sigma factor activity
Tthe_1429	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Tthe_1430	COG1776	CheC inhibitor of MCP methylation
Tthe_1432	COG2198	Histidine kinase
Tthe_1432	COG0643	Histidine kinase
Tthe_1434	COG0455	bacterial-type flagellum organization
Tthe_1436	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Tthe_1437	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Tthe_1438	COG1684	flagellar biosynthetic protein fliR
Tthe_1439	COG1987	bacterial-type flagellum assembly
Tthe_1440	COG1338	Plays a role in the flagellum-specific transport system
Tthe_1442	COG2201	protein-glutamate methylesterase activity
Tthe_1443	COG1776	CheC inhibitor of MCP methylation
Tthe_1443	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Tthe_1444	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Tthe_1445	COG1580	Controls the rotational direction of flagella during chemotaxis
Tthe_1446	COG1582	Flagellar protein (FlbD)
Tthe_1448	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Tthe_1452	COG1157	protein secretion by the type III secretion system
Tthe_1454	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Tthe_1455	COG1766	The M ring may be actively involved in energy transduction
Tthe_1456	COG1677	Flagellar hook-basal body complex protein FliE
Tthe_1458	COG1815	bacterial-type flagellum-dependent cell motility
Tthe_1460	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Tthe_1461	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Tthe_1462	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Tthe_1463	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Tthe_1463	COG0758	DNA mediated transformation
Tthe_1464	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Tthe_1466	COG0180	Tryptophanyl-tRNA synthetase
Tthe_1467	COG0606	chelatase, subunit chli
Tthe_1469	COG0335	large ribosomal subunit rRNA binding
Tthe_1470	COG0336	Belongs to the RNA methyltransferase TrmD family
Tthe_1471	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Tthe_1472	COG1837	Belongs to the UPF0109 family
Tthe_1473	COG0228	four-way junction DNA binding
Tthe_1474	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Tthe_1475	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
Tthe_1482	COG1136	(ABC) transporter
Tthe_1485	COG1595	DNA-templated transcription, initiation
Tthe_1486	COG0552	protein localization to endoplasmic reticulum
Tthe_1487	COG1196	nuclear chromosome segregation
Tthe_1488	COG2359	stage V sporulation protein S
Tthe_1490	COG0571	ribonuclease III activity
Tthe_1491	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Tthe_1492	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Tthe_1494	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Tthe_1495	COG2070	2-Nitropropane dioxygenase
Tthe_1496	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Tthe_1497	COG0416	fatty acid biosynthetic process
Tthe_1498	COG2030	dehydratase
Tthe_1499	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Tthe_1500	COG1399	metal-binding, possibly nucleic acid-binding protein
Tthe_1501	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Tthe_1502	COG0280	phosphate acetyltransferase
Tthe_1504	COG3314	Sporulation integral membrane protein YlbJ
Tthe_1506	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Tthe_1507	COG0742	ribosomal rna small subunit methyltransferase
Tthe_1510	COG1307	EDD domain protein, DegV family
Tthe_1511	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Tthe_1512	COG1461	Dihydroxyacetone kinase
Tthe_1513	COG1302	Protein conserved in bacteria
Tthe_1518	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Tthe_1519	COG1162	GTPase activity
Tthe_1520	COG2815	serine threonine protein kinase
Tthe_1520	COG0515	serine threonine protein kinase
Tthe_1521	COG0631	protein serine/threonine phosphatase activity
Tthe_1522	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Tthe_1523	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Tthe_1523	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Tthe_1524	COG2738	Putative neutral zinc metallopeptidase
Tthe_1526	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Tthe_1527	COG0242	peptide deformylase activity
Tthe_1528	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Tthe_1529	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Tthe_1531	COG0194	GDP metabolic process
Tthe_1533	COG1561	YicC-like family, N-terminal region
Tthe_1534	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Tthe_1539	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Tthe_1540	COG0167	dihydroorotate dehydrogenase activity
Tthe_1541	COG0543	2 iron, 2 sulfur cluster binding
Tthe_1543	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Tthe_1544	COG0540	Belongs to the ATCase OTCase family
Tthe_1545	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Tthe_1548	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tthe_1550	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Tthe_1551	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Tthe_1552	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Tthe_1552	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Tthe_1555	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Tthe_1556	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Tthe_1562	COG0343	queuine tRNA-ribosyltransferase activity
Tthe_1563	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Tthe_1564	COG2385	sporulation resulting in formation of a cellular spore
Tthe_1566	COG2255	four-way junction helicase activity
Tthe_1567	COG0632	four-way junction helicase activity
Tthe_1568	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Tthe_1570	COG0835	chemotaxis
Tthe_1571	COG0217	transcriptional regulatory protein
Tthe_1572	COG0730	response to heat
Tthe_1576	COG1739	Uncharacterized protein family UPF0029
Tthe_1577	COG0494	nUDIX hydrolase
Tthe_1579	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Tthe_1584	COG0175	sulfate reduction
Tthe_1585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Tthe_1588	COG0175	sulfate reduction
Tthe_1592	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Tthe_1595	COG0113	porphobilinogen synthase activity
Tthe_1596	COG1648	precorrin-2 dehydrogenase activity
Tthe_1596	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Tthe_1597	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Tthe_1599	COG0181	hydroxymethylbilane synthase activity
Tthe_1600	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Tthe_1601	COG4172	Belongs to the ABC transporter superfamily
Tthe_1602	COG0444	Belongs to the ABC transporter superfamily
Tthe_1604	COG0601	transmembrane transport
Tthe_1605	COG4166	transmembrane transport
Tthe_1607	COG2078	PFAM AMMECR1 domain protein
Tthe_1607	COG3885	ferrous iron binding
Tthe_1608	COG0789	Transcriptional regulator
Tthe_1609	COG0477	Major facilitator Superfamily
Tthe_1610	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Tthe_1611	COG1982	Orn Lys Arg decarboxylase major
Tthe_1613	COG2205	protein histidine kinase activity
Tthe_1614	COG0745	RESPONSE REGULATOR receiver
Tthe_1616	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Tthe_1617	COG0785	Cytochrome C biogenesis protein
Tthe_1618	COG0363	glucosamine-6-phosphate deaminase activity
Tthe_1619	COG1940	carbohydrate kinase activity
Tthe_1624	COG2119	membrane
Tthe_1625	COG3409	Peptidoglycan-binding domain 1 protein
Tthe_1625	COG3773	Cell wall hydrolase
Tthe_1627	COG5002	protein histidine kinase activity
Tthe_1628	COG0745	RESPONSE REGULATOR receiver
Tthe_1629	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Tthe_1630	COG0287	Prephenate dehydrogenase
Tthe_1631	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Tthe_1632	COG0077	Prephenate dehydratase
Tthe_1632	COG1605	Chorismate mutase
Tthe_1633	COG0318	PFAM AMP-dependent synthetase and ligase
Tthe_1634	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Tthe_1635	COG1760	l-serine dehydratase
Tthe_1637	COG1164	Oligoendopeptidase f
Tthe_1639	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Tthe_1640	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Tthe_1642	COG0426	domain, Protein
Tthe_1643	COG3069	C4-dicarboxylate transmembrane transporter activity
Tthe_1646	COG1968	undecaprenyl-diphosphatase activity
Tthe_1647	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Tthe_1649	COG0584	glycerophosphoryl diester phosphodiesterase
Tthe_1650	COG1032	radical SAM domain protein
Tthe_1652	COG4086	secreted protein
Tthe_1653	COG3858	chitin binding
Tthe_1654	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
Tthe_1655	COG0427	acetyl-CoA hydrolase
Tthe_1656	COG0183	Belongs to the thiolase family
Tthe_1657	COG1250	3-hydroxyacyl-CoA dehydrogenase
Tthe_1658	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Tthe_1659	COG2086	electron transfer activity
Tthe_1660	COG1960	acyl-CoA dehydrogenase activity
Tthe_1661	COG1024	Enoyl-CoA hydratase
Tthe_1662	COG3875	lactate racemase activity
Tthe_1663	COG0277	FAD linked oxidase domain protein
Tthe_1664	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Tthe_1665	COG2086	electron transfer activity
Tthe_1666	COG1620	l-lactate permease
Tthe_1667	COG2186	Transcriptional regulator
Tthe_1668	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Tthe_1672	COG0561	phosphatase activity
Tthe_1683	COG3964	amidohydrolase
Tthe_1684	COG3711	transcriptional antiterminator
Tthe_1688	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Tthe_1689	COG3457	Alanine racemase
Tthe_1690	COG0626	cystathionine gamma-synthase activity
Tthe_1691	COG1735	metal-dependent hydrolase with the TIM-barrel fold
Tthe_1696	COG2188	Transcriptional regulator
Tthe_1698	COG2313	pseudouridylate synthase activity
Tthe_1699	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Tthe_1699	COG1522	sequence-specific DNA binding
Tthe_1700	COG1122	ATPase activity
Tthe_1722	COG1879	ABC-type sugar transport system periplasmic component
Tthe_1723	COG1172	Belongs to the binding-protein-dependent transport system permease family
Tthe_1724	COG1129	ABC transporter
Tthe_1725	COG1869	D-ribose catabolic process
Tthe_1726	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Tthe_1728	COG0191	fructose-bisphosphate aldolase activity
Tthe_1730	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Tthe_1731	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Tthe_1732	COG1063	alcohol dehydrogenase
Tthe_1736	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tthe_1736	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Tthe_1737	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Tthe_1737	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Tthe_1748	COG0704	Plays a role in the regulation of phosphate uptake
Tthe_1749	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Tthe_1750	COG0581	inorganic phosphate transmembrane transporter activity
Tthe_1751	COG0573	inorganic phosphate transmembrane transporter activity
Tthe_1752	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Tthe_1753	COG5002	protein histidine kinase activity
Tthe_1754	COG0745	RESPONSE REGULATOR receiver
Tthe_1756	COG1873	PFAM PRC-barrel domain
Tthe_1757	COG1191	sigma factor activity
Tthe_1758	COG1191	sigma factor activity
Tthe_1760	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Tthe_1761	COG0849	cell division
Tthe_1762	COG3856	small basic protein
Tthe_1764	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Tthe_1765	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Tthe_1766	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Tthe_1767	COG0772	Belongs to the SEDS family
Tthe_1769	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Tthe_1770	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Tthe_1771	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Tthe_1772	COG0768	penicillin binding
Tthe_1776	COG0612	Peptidase, M16
Tthe_1777	COG0612	Peptidase, M16
Tthe_1779	COG0012	GTP binding
Tthe_1785	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Tthe_1787	COG1937	Protein conserved in bacteria
Tthe_1788	COG0438	transferase activity, transferring glycosyl groups
Tthe_1792	COG2340	Cysteine-rich secretory protein family
Tthe_1793	COG1362	aminopeptidase activity
Tthe_1794	COG2197	response regulator
Tthe_1797	COG1193	negative regulation of DNA recombination
Tthe_1798	COG0826	peptidase U32
Tthe_1800	COG0072	phenylalanine-tRNA ligase activity
Tthe_1800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tthe_1801	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Tthe_1802	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Tthe_1803	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Tthe_1804	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Tthe_1805	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Tthe_1806	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Tthe_1808	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Tthe_1809	COG4399	Belongs to the UPF0754 family
Tthe_1812	COG0745	RESPONSE REGULATOR receiver
Tthe_1815	COG0367	asparagine synthase
Tthe_1816	COG0347	Belongs to the P(II) protein family
Tthe_1817	COG0004	ammonium transporteR
Tthe_1819	COG0004	ammonium transporteR
Tthe_1821	COG0371	Dehydrogenase
Tthe_1823	COG0390	transport system, permease component
Tthe_1824	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Tthe_1828	COG0673	inositol 2-dehydrogenase activity
Tthe_1829	COG3716	PTS system mannose fructose sorbose family IID component
Tthe_1830	COG3715	PTS system
Tthe_1831	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Tthe_1831	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tthe_1832	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tthe_1832	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Tthe_1833	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Tthe_1833	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Tthe_1834	COG1122	ATPase activity
Tthe_1837	COG0310	cobalt ion transport
Tthe_1841	COG2875	Belongs to the precorrin methyltransferase family
Tthe_1843	COG2242	protein methyltransferase activity
Tthe_1851	COG2814	Major facilitator Superfamily
Tthe_1861	COG0347	Belongs to the P(II) protein family
Tthe_1862	COG0347	Belongs to the P(II) protein family
Tthe_1866	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Tthe_1867	COG1433	Dinitrogenase iron-molybdenum cofactor
Tthe_1867	COG0535	radical SAM domain protein
Tthe_1868	COG0535	radical SAM domain protein
Tthe_1868	COG1433	Dinitrogenase iron-molybdenum cofactor
Tthe_1873	COG0352	thiamine-phosphate diphosphorylase activity
Tthe_1876	COG0352	thiamine-phosphate diphosphorylase activity
Tthe_1876	COG0351	phosphomethylpyrimidine kinase
Tthe_1879	COG1132	(ABC) transporter
Tthe_1881	COG0697	spore germination
Tthe_1882	COG5002	protein histidine kinase activity
Tthe_1888	COG1966	Carbon starvation protein
Tthe_1889	COG3279	Response regulator of the LytR AlgR family
Tthe_1890	COG3275	phosphorelay sensor kinase activity
Tthe_1896	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Tthe_1897	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
Tthe_1902	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Tthe_1903	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Tthe_1904	COG0698	ribose 5-phosphate isomerase
Tthe_1905	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Tthe_1907	COG3958	Transketolase
Tthe_1908	COG3959	Transketolase, thiamine diphosphate binding domain
Tthe_1911	COG3775	system Galactitol-specific IIC component
Tthe_1912	COG3414	Phosphotransferase system galactitol-specific IIB component
Tthe_1918	COG1609	Transcriptional regulator
Tthe_1921	COG0366	Alpha amylase catalytic
Tthe_1922	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Tthe_1928	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Tthe_1929	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Tthe_1932	COG1175	transmembrane transport
Tthe_1934	COG1609	Transcriptional regulator
Tthe_1936	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Tthe_1937	COG2942	2-epimerase
Tthe_1941	COG0346	lactoylglutathione lyase activity
Tthe_1944	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Tthe_1946	COG0569	domain protein
Tthe_1947	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Tthe_1950	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Tthe_1952	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Tthe_1953	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Tthe_1955	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Tthe_1957	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tthe_1959	COG5002	protein histidine kinase activity
Tthe_1960	COG0745	RESPONSE REGULATOR receiver
Tthe_1965	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Tthe_1972	COG0726	polysaccharide deacetylase
Tthe_1974	COG5002	protein histidine kinase activity
Tthe_1975	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Tthe_1976	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
Tthe_1977	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
Tthe_1978	COG2205	protein histidine kinase activity
Tthe_1980	COG5002	protein histidine kinase activity
Tthe_1980	COG3850	Histidine kinase
Tthe_1981	COG0745	RESPONSE REGULATOR receiver
Tthe_1983	COG0367	asparagine synthase
Tthe_1984	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Tthe_1986	COG0728	peptidoglycan biosynthetic process
Tthe_1988	COG1070	Carbohydrate kinase
Tthe_1991	COG0390	transport system, permease component
Tthe_1992	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Tthe_1993	COG1278	Cold shock
Tthe_1994	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Tthe_1997	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Tthe_1998	COG1902	pentaerythritol trinitrate reductase activity
Tthe_2000	COG1704	LemA family
Tthe_2001	COG1956	GAF domain-containing protein
Tthe_2002	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Tthe_2007	COG1482	cell wall glycoprotein biosynthetic process
Tthe_2008	COG0813	purine-nucleoside phosphorylase activity
Tthe_2009	COG0482	sulfurtransferase activity
Tthe_2010	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Tthe_2011	COG2384	SAM-dependent methyltransferase
Tthe_2012	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Tthe_2013	COG0358	DNA primase activity
Tthe_2014	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Tthe_2015	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Tthe_2016	COG1342	Belongs to the UPF0251 family
Tthe_2017	COG0148	phosphopyruvate hydratase activity
Tthe_2019	COG0149	triose-phosphate isomerase activity
Tthe_2020	COG0126	phosphoglycerate kinase activity
Tthe_2023	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Tthe_2024	COG1254	Belongs to the acylphosphatase family
Tthe_2025	COG0561	phosphatase activity
Tthe_2026	COG0735	belongs to the Fur family
Tthe_2027	COG2720	vancomycin resistance protein
Tthe_2029	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Tthe_2030	COG1067	ATP-dependent peptidase activity
Tthe_2037	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Tthe_2038	COG1592	Rubrerythrin
Tthe_2038	COG1773	rubredoxin
Tthe_2047	COG0564	pseudouridine synthase activity
Tthe_2050	COG2309	aminopeptidase activity
Tthe_2051	COG1074	ATP-dependent DNA helicase activity
Tthe_2053	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Tthe_2054	COG1304	FMN binding
Tthe_2055	COG0778	Nitroreductase
Tthe_2057	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Tthe_2060	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Tthe_2063	COG0457	Tetratricopeptide repeat
Tthe_2063	COG0463	Glycosyl transferase, family 2
Tthe_2065	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Tthe_2066	COG0840	transmembrane signaling receptor activity
Tthe_2073	COG1752	Esterase of the alpha-beta hydrolase superfamily
Tthe_2075	COG1309	transcriptional regulator
Tthe_2076	COG0622	Phosphoesterase
Tthe_2078	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Tthe_2079	COG0860	N-Acetylmuramoyl-L-alanine amidase
Tthe_2081	COG4608	Belongs to the ABC transporter superfamily
Tthe_2082	COG0444	Belongs to the ABC transporter superfamily
Tthe_2083	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Tthe_2084	COG0601	transmembrane transport
Tthe_2085	COG4166	transmembrane transport
Tthe_2086	COG4166	transmembrane transport
Tthe_2087	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Tthe_2088	COG0154	amidase activity
Tthe_2089	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Tthe_2090	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Tthe_2092	COG4496	protein, YerC YecD
Tthe_2093	COG1447	Phosphotransferase system cellobiose-specific component IIA
Tthe_2094	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Tthe_2097	COG3711	transcriptional antiterminator
Tthe_2098	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Tthe_2099	COG2011	ABC-type metal ion transport system permease component
Tthe_2101	COG2244	polysaccharide biosynthetic process
Tthe_2105	COG1473	amidohydrolase
Tthe_2107	COG0151	Belongs to the GarS family
Tthe_2108	COG0138	bifunctional purine biosynthesis protein purh
Tthe_2109	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Tthe_2110	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Tthe_2111	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Tthe_2112	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Tthe_2113	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Tthe_2115	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Tthe_2115	COG0519	Catalyzes the synthesis of GMP from XMP
Tthe_2116	COG0516	GMP reductase activity
Tthe_2116	COG0517	IMP dehydrogenase activity
Tthe_2117	COG0459	protein refolding
Tthe_2123	COG1404	Belongs to the peptidase S8 family
Tthe_2125	COG3842	ATPase activity
Tthe_2126	COG4120	Belongs to the binding-protein-dependent transport system permease family
Tthe_2129	COG0559	Belongs to the binding-protein-dependent transport system permease family
Tthe_2131	COG0411	ABC transporter
Tthe_2134	COG1132	(ABC) transporter
Tthe_2144	COG1811	Na channel or pump
Tthe_2149	COG1914	H( )-stimulated, divalent metal cation uptake system
Tthe_2151	COG1360	Flagellar Motor Protein
Tthe_2153	COG0488	(ABC) transporter
Tthe_2155	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Tthe_2156	COG0456	acetyltransferase
Tthe_2157	COG1214	PFAM Peptidase M22, glycoprotease
Tthe_2158	COG0802	atpase or kinase
Tthe_2161	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Tthe_2163	COG0398	Pfam SNARE associated Golgi protein
Tthe_2164	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Tthe_2165	COG2183	response to ionizing radiation
Tthe_2167	COG0653	protein targeting
Tthe_2169	COG1827	regulation of RNA biosynthetic process
Tthe_2174	COG1126	abc transporter atp-binding protein
Tthe_2175	COG0765	amino acid transport
Tthe_2176	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Tthe_2179	COG1516	flagellar protein fliS
Tthe_2180	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Tthe_2183	COG0632	four-way junction helicase activity
Tthe_2187	COG0457	Tetratricopeptide repeat
Tthe_2187	COG0463	Glycosyl transferase, family 2
Tthe_2191	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Tthe_2192	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
Tthe_2194	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Tthe_2195	COG4786	Flagellar basal body rod
Tthe_2195	COG1256	bacterial-type flagellum assembly
Tthe_2199	COG1040	competence protein
Tthe_2200	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Tthe_2202	COG2199	diguanylate cyclase activity
Tthe_2202	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Tthe_2203	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Tthe_2204	COG1592	Rubrerythrin
Tthe_2211	COG5002	protein histidine kinase activity
Tthe_2212	COG0745	RESPONSE REGULATOR receiver
Tthe_2213	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Tthe_2214	COG1609	Transcriptional regulator
Tthe_2216	COG0561	phosphatase activity
Tthe_2217	COG2323	membrane
Tthe_2222	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Tthe_2224	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Tthe_2226	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Tthe_2228	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Tthe_2229	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Tthe_2230	COG3711	transcriptional antiterminator
Tthe_2231	COG0840	transmembrane signaling receptor activity
Tthe_2233	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Tthe_2234	COG0295	cytidine deaminase activity
Tthe_2235	COG2188	Transcriptional regulator
Tthe_2239	COG1744	ABC transporter substrate-binding protein PnrA-like
Tthe_2240	COG3404	Formiminotransferase-cyclodeaminase
Tthe_2257	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
Tthe_2258	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Tthe_2263	COG1797	cobyrinic acid a,c-diamide synthase activity
Tthe_2264	COG1120	ATPase activity
Tthe_2265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Tthe_2266	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Tthe_2270	COG5464	transposase or invertase
Tthe_2279	COG1131	(ABC) transporter
Tthe_2284	COG1131	(ABC) transporter
Tthe_2294	COG0116	Belongs to the methyltransferase superfamily
Tthe_2295	COG2226	methyltransferase
Tthe_2297	COG1522	sequence-specific DNA binding
Tthe_2298	COG0436	Aminotransferase
Tthe_2302	COG0671	phosphoesterase, PA-phosphatase related
Tthe_2304	COG0803	Belongs to the bacterial solute-binding protein 9 family
Tthe_2305	COG1121	(ABC) transporter
Tthe_2306	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Tthe_2310	COG1132	(ABC) transporter
Tthe_2312	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Tthe_2313	COG1136	(ABC) transporter
Tthe_2315	COG1136	(ABC) transporter
Tthe_2323	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Tthe_2341	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Tthe_2344	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Tthe_2345	COG0737	Belongs to the 5'-nucleotidase family
Tthe_2348	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Tthe_2348	COG1263	PTS System
Tthe_2349	COG2190	(PTS) system
Tthe_2350	COG1737	Transcriptional regulator
Tthe_2351	COG1486	melibiose metabolic process
Tthe_2355	COG1447	Phosphotransferase system cellobiose-specific component IIA
Tthe_2357	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Tthe_2359	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Tthe_2359	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Tthe_2360	COG0531	amino acid
Tthe_2361	COG4166	transmembrane transport
Tthe_2364	COG0495	leucyl-tRNA aminoacylation
Tthe_2368	COG0436	Aminotransferase
Tthe_2369	COG4214	carbohydrate transport
Tthe_2371	COG4213	ABC transporter substrate-binding protein
Tthe_2372	COG4213	ABC transporter substrate-binding protein
Tthe_2373	COG4753	response regulator
Tthe_2373	COG2207	Transcriptional regulator
Tthe_2374	COG3275	phosphorelay sensor kinase activity
Tthe_2379	COG4211	Belongs to the binding-protein-dependent transport system permease family
Tthe_2382	COG1028	Short-chain dehydrogenase reductase Sdr
Tthe_2383	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
Tthe_2384	COG1609	Transcriptional regulator
Tthe_2387	COG0246	Mannitol dehydrogenase
Tthe_2388	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Tthe_2389	COG1070	Carbohydrate kinase
Tthe_2390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Tthe_2392	COG1349	DNA-binding transcription factor activity
Tthe_2394	COG0534	Mate efflux family protein
Tthe_2395	COG2721	sulfolactate sulfo-lyase activity
Tthe_2396	COG0246	Mannitol dehydrogenase
Tthe_2397	COG1486	melibiose metabolic process
Tthe_2399	COG0395	ABC-type sugar transport system, permease component
Tthe_2400	COG1175	transmembrane transport
Tthe_2402	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
Tthe_2403	COG1609	Transcriptional regulator
Tthe_2404	COG1904	glucuronate isomerase
Tthe_2407	COG1388	LysM domain
Tthe_2407	COG0791	NLP P60 protein
Tthe_2409	COG0493	'glutamate synthase
Tthe_2412	COG0039	L-malate dehydrogenase activity
Tthe_2416	COG0586	Pfam SNARE associated Golgi protein
Tthe_2417	COG0297	glycogen (starch) synthase activity
Tthe_2419	COG1085	galactose-1-phosphate uridylyltransferase
Tthe_2424	COG1486	melibiose metabolic process
Tthe_2430	COG4716	Myosin-crossreactive antigen
Tthe_2432	COG3875	lactate racemase activity
Tthe_2433	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Tthe_2435	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Tthe_2440	COG0534	Mate efflux family protein
Tthe_2441	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Tthe_2443	COG2217	Heavy metal translocating P-type atpase
Tthe_2448	COG0864	Transcriptional regulator
Tthe_2449	COG0310	cobalt ion transport
Tthe_2450	COG0310	cobalt ion transport
Tthe_2452	COG1122	ATPase activity
Tthe_2456	COG1595	DNA-templated transcription, initiation
Tthe_2459	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Tthe_2463	COG2721	sulfolactate sulfo-lyase activity
Tthe_2464	COG0698	ribose 5-phosphate isomerase
Tthe_2465	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Tthe_2466	COG0800	Aldolase
Tthe_2467	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Tthe_2469	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Tthe_2470	COG3716	PTS system mannose fructose sorbose family IID component
Tthe_2472	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tthe_2472	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Tthe_2473	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Tthe_2473	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Tthe_2482	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Tthe_2484	COG1609	Transcriptional regulator
Tthe_2485	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Tthe_2488	COG4214	carbohydrate transport
Tthe_2490	COG4213	ABC transporter substrate-binding protein
Tthe_2491	COG1070	Carbohydrate kinase
Tthe_2492	COG2115	Belongs to the xylose isomerase family
Tthe_2493	COG3973	AAA domain
Tthe_2494	COG2267	carboxylic ester hydrolase activity
Tthe_2495	COG1902	pentaerythritol trinitrate reductase activity
Tthe_2495	COG0446	pyridine nucleotide-disulphide oxidoreductase
Tthe_2499	COG4632	Exopolysaccharide biosynthesis protein
Tthe_2499	COG5434	Belongs to the glycosyl hydrolase 28 family
Tthe_2500	COG1979	alcohol dehydrogenase
Tthe_2501	COG0840	transmembrane signaling receptor activity
Tthe_2506	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Tthe_2509	COG4786	Flagellar basal body rod
Tthe_2511	COG1609	Transcriptional regulator
Tthe_2513	COG2385	sporulation resulting in formation of a cellular spore
Tthe_2521	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Tthe_2522	COG0531	amino acid
Tthe_2524	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Tthe_2526	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Tthe_2527	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Tthe_2529	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Tthe_2530	COG0698	ribose 5-phosphate isomerase
Tthe_2531	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Tthe_2532	COG0009	L-threonylcarbamoyladenylate synthase
Tthe_2535	COG2890	protein-(glutamine-N5) methyltransferase activity
Tthe_2536	COG3872	metal-dependent enzyme
Tthe_2537	COG1435	thymidine kinase activity
Tthe_2538	COG0254	rRNA binding
Tthe_2539	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Tthe_2542	COG0745	RESPONSE REGULATOR receiver
Tthe_2543	COG0860	N-Acetylmuramoyl-L-alanine amidase
Tthe_2543	COG2247	cell wall binding repeat
Tthe_2546	COG1132	(ABC) transporter
Tthe_2547	COG1132	(ABC) transporter
Tthe_2551	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Tthe_2551	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Tthe_2551	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tthe_2552	COG1105	Belongs to the carbohydrate kinase PfkB family
Tthe_2553	COG1349	DNA-binding transcription factor activity
Tthe_2558	COG1216	Glycosyl transferase, family 2
Tthe_2564	COG2205	protein histidine kinase activity
Tthe_2564	COG2770	Histidine kinase
Tthe_2565	COG0745	RESPONSE REGULATOR receiver
Tthe_2568	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Tthe_2573	COG1566	PFAM secretion protein HlyD family protein
Tthe_2574	COG2814	Major facilitator Superfamily
Tthe_2576	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tthe_2580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tthe_2583	COG2373	Large extracellular alpha-helical protein
Tthe_2587	COG0504	CTP synthase activity
Tthe_2588	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Tthe_2593	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Tthe_2594	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Tthe_2595	COG1929	Belongs to the glycerate kinase type-1 family
Tthe_2596	COG3409	Peptidoglycan-binding domain 1 protein
Tthe_2596	COG0793	Belongs to the peptidase S41A family
Tthe_2597	COG0083	homoserine kinase activity
Tthe_2598	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Tthe_2599	COG0460	homoserine dehydrogenase
Tthe_2600	COG4492	Belongs to the UPF0735 family
Tthe_2602	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Tthe_2603	COG0674	pyruvate-flavodoxin oxidoreductase activity
Tthe_2603	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Tthe_2604	COG1013	pyruvate-flavodoxin oxidoreductase activity
Tthe_2605	COG1132	(ABC) transporter
Tthe_2607	COG1846	Transcriptional regulator
Tthe_2609	COG0038	chloride channel
Tthe_2611	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Tthe_2612	COG1518	maintenance of DNA repeat elements
Tthe_2617	COG3693	PFAM glycoside hydrolase, family 10
Tthe_2628	COG1337	RAMP superfamily
Tthe_2635	COG0822	iron-sulfur transferase activity
Tthe_2636	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Tthe_2637	COG0719	Fe-S assembly protein
Tthe_2638	COG0719	Fe-S assembly protein
Tthe_2646	COG1454	alcohol dehydrogenase
Tthe_2646	COG1012	belongs to the aldehyde dehydrogenase family
Tthe_2648	COG0667	Aldo Keto reductase
Tthe_2652	COG1924	4 iron, 4 sulfur cluster binding
Tthe_2653	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Tthe_2656	COG1653	transport
Tthe_2657	COG2972	Histidine kinase
Tthe_2658	COG4753	response regulator
Tthe_2658	COG2207	Transcriptional regulator
Tthe_2680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tthe_2681	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Tthe_2685	COG5002	protein histidine kinase activity
Tthe_2686	COG0745	RESPONSE REGULATOR receiver
Tthe_2688	COG0739	heme binding
Tthe_2697	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Tthe_2698	COG1518	maintenance of DNA repeat elements
Tthe_2703	COG1203	CRISPR-associated helicase, Cas3
Tthe_2715	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Tthe_2716	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Tthe_2721	COG2205	protein histidine kinase activity
Tthe_2721	COG2770	Histidine kinase
Tthe_2722	COG0745	RESPONSE REGULATOR receiver
Tthe_2724	COG2239	Acts as a magnesium transporter
Tthe_2728	COG0305	Participates in initiation and elongation during chromosome replication
Tthe_2729	COG0359	binds to the 23S rRNA
Tthe_2730	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
Tthe_2733	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Tthe_2734	COG0629	single-stranded DNA binding
Tthe_2735	COG0360	Binds together with S18 to 16S ribosomal RNA
Tthe_2736	COG4481	Protein conserved in bacteria
Tthe_2737	COG0668	transmembrane transport
Tthe_2740	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Tthe_2740	COG0189	ligase activity
Tthe_2742	COG1597	lipid kinase activity
Tthe_2744	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Tthe_2745	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Tthe_2746	COG1475	DNA binding
Tthe_2747	COG1192	Involved in chromosome partitioning
Tthe_2750	COG0357	Ribosomal RNA small subunit methyltransferase G
Tthe_2751	COG0445	tRNA wobble uridine modification
Tthe_2752	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Tthe_2753	COG1847	R3H domain protein
Tthe_2754	COG0706	membrane insertase activity
Tthe_2755	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Tthe_2756	COG0594	ribonuclease P activity
Tthe_2757	COG0230	Belongs to the bacterial ribosomal protein bL34 family