locus-tag	class	description
Thethe_00001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Thethe_00002	COG0592	DNA-directed DNA polymerase activity
Thethe_00003	COG2501	S4 domain
Thethe_00008	COG0187	DNA topoisomerase II activity
Thethe_00009	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Thethe_00012	COG0440	acetolactate synthase activity
Thethe_00013	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Thethe_00014	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Thethe_00015	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Thethe_00016	COG0066	3-isopropylmalate dehydratase activity
Thethe_00017	COG0473	3-isopropylmalate dehydrogenase activity
Thethe_00018	COG0129	dihydroxy-acid dehydratase activity
Thethe_00019	COG0028	Belongs to the TPP enzyme family
Thethe_00027	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Thethe_00031	COG1316	TRANSCRIPTIONal
Thethe_00032	COG1615	UPF0182 protein
Thethe_00037	COG0590	tRNA wobble adenosine to inosine editing
Thethe_00041	COG2199	diguanylate cyclase activity
Thethe_00041	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Thethe_00042	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Thethe_00043	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Thethe_00044	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Thethe_00045	COG0460	homoserine dehydrogenase
Thethe_00047	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Thethe_00049	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Thethe_00058	COG1028	Short-chain dehydrogenase reductase Sdr
Thethe_00059	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Thethe_00062	COG1187	pseudouridine synthase activity
Thethe_00063	COG1882	Formate acetyltransferase
Thethe_00064	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Thethe_00065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Thethe_00066	COG1028	Short-chain dehydrogenase reductase Sdr
Thethe_00067	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Thethe_00069	COG1573	uracil-dna glycosylase
Thethe_00073	COG1940	carbohydrate kinase activity
Thethe_00074	COG0519	Catalyzes the synthesis of GMP from XMP
Thethe_00077	COG1982	Orn Lys Arg decarboxylase major
Thethe_00078	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Thethe_00079	COG3870	Protein conserved in bacteria
Thethe_00082	COG1774	PSP1 C-terminal conserved region
Thethe_00084	COG0730	response to heat
Thethe_00086	COG2235	arginine
Thethe_00087	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Thethe_00088	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Thethe_00089	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Thethe_00090	COG2002	toxin-antitoxin pair type II binding
Thethe_00091	COG2715	membrane protein required for spore maturation
Thethe_00092	COG0700	Nucleoside recognition
Thethe_00094	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Thethe_00094	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Thethe_00099	COG0084	hydrolase, TatD family'
Thethe_00101	COG3584	3D domain protein
Thethe_00101	COG3583	domain protein
Thethe_00102	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Thethe_00106	COG0489	protein tyrosine kinase activity
Thethe_00112	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Thethe_00112	COG2111	Na H antiporter
Thethe_00114	COG3260	NADH ubiquinone oxidoreductase 20
Thethe_00117	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Thethe_00118	COG0375	protein maturation
Thethe_00120	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Thethe_00121	COG0298	carbon dioxide binding
Thethe_00122	COG0409	Hydrogenase expression formation protein
Thethe_00124	COG3409	Peptidoglycan-binding domain 1 protein
Thethe_00124	COG3773	Cell wall hydrolase
Thethe_00129	COG1131	(ABC) transporter
Thethe_00131	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Thethe_00133	COG2221	Nitrite and sulphite reductase 4Fe-4S
Thethe_00167	COG0789	Transcriptional regulator
Thethe_00168	COG1664	Polymer-forming cytoskeletal
Thethe_00170	COG0071	Belongs to the small heat shock protein (HSP20) family
Thethe_00172	COG1609	Transcriptional regulator
Thethe_00173	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Thethe_00174	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Thethe_00176	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Thethe_00177	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Thethe_00179	COG3850	Histidine kinase
Thethe_00179	COG5002	protein histidine kinase activity
Thethe_00180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Thethe_00183	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Thethe_00184	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Thethe_00185	COG2002	toxin-antitoxin pair type II binding
Thethe_00187	COG4466	Protein conserved in bacteria
Thethe_00189	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Thethe_00190	COG1802	Transcriptional regulator
Thethe_00193	COG0697	spore germination
Thethe_00194	COG0531	amino acid
Thethe_00197	COG1982	Orn Lys Arg decarboxylase major
Thethe_00198	COG3773	Cell wall hydrolase
Thethe_00198	COG3409	Peptidoglycan-binding domain 1 protein
Thethe_00199	COG2959	enzyme of heme biosynthesis
Thethe_00202	COG1175	transmembrane transport
Thethe_00203	COG0395	ABC-type sugar transport system, permease component
Thethe_00204	COG1609	Transcriptional regulator
Thethe_00207	COG1181	Belongs to the D-alanine--D-alanine ligase family
Thethe_00209	COG0018	arginyl-trna synthetase
Thethe_00211	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Thethe_00212	COG1131	(ABC) transporter
Thethe_00214	COG0531	amino acid
Thethe_00216	COG0667	Aldo Keto reductase
Thethe_00218	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Thethe_00219	COG3859	Proton-coupled thiamine transporter YuaJ
Thethe_00220	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Thethe_00221	COG0671	phosphoesterase, PA-phosphatase related
Thethe_00228	COG5434	Belongs to the glycosyl hydrolase 28 family
Thethe_00228	COG4632	Exopolysaccharide biosynthesis protein
Thethe_00229	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Thethe_00237	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Thethe_00238	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Thethe_00240	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Thethe_00241	COG0505	Belongs to the CarA family
Thethe_00242	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Thethe_00244	COG0165	Argininosuccinate lyase
Thethe_00246	COG0446	pyridine nucleotide-disulphide oxidoreductase
Thethe_00247	COG0586	Pfam SNARE associated Golgi protein
Thethe_00250	COG2033	superoxide reductase activity
Thethe_00251	COG1027	Aspartate ammonia-lyase
Thethe_00252	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Thethe_00253	COG2211	Major facilitator Superfamily
Thethe_00255	COG3956	TIGRFAM MazG family protein
Thethe_00256	COG0776	regulation of translation
Thethe_00257	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Thethe_00258	COG2385	sporulation resulting in formation of a cellular spore
Thethe_00264	COG1098	S1 RNA binding domain
Thethe_00265	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Thethe_00265	COG0248	Ppx GppA phosphatase
Thethe_00271	COG0840	transmembrane signaling receptor activity
Thethe_00274	COG0653	protein targeting
Thethe_00278	COG0860	N-Acetylmuramoyl-L-alanine amidase
Thethe_00280	COG2233	PERMEase
Thethe_00282	COG0842	Transport permease protein
Thethe_00283	COG1131	(ABC) transporter
Thethe_00285	COG1309	transcriptional regulator
Thethe_00286	COG1013	pyruvate-flavodoxin oxidoreductase activity
Thethe_00286	COG0674	pyruvate-flavodoxin oxidoreductase activity
Thethe_00286	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Thethe_00286	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Thethe_00291	COG1131	(ABC) transporter
Thethe_00293	COG1595	DNA-templated transcription, initiation
Thethe_00295	COG3830	Belongs to the UPF0237 family
Thethe_00297	COG2226	methyltransferase
Thethe_00302	COG2226	methyltransferase
Thethe_00304	COG2208	phosphoserine phosphatase activity
Thethe_00307	COG0037	tRNA processing
Thethe_00312	COG5002	protein histidine kinase activity
Thethe_00316	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Thethe_00318	COG4770	biotin carboxylase activity
Thethe_00319	COG4684	Psort location CytoplasmicMembrane, score
Thethe_00320	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Thethe_00322	COG0697	spore germination
Thethe_00327	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Thethe_00327	COG5322	oxidoreductase activity
Thethe_00328	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Thethe_00329	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Thethe_00330	COG0302	gtp cyclohydrolase
Thethe_00331	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Thethe_00332	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Thethe_00333	COG0720	synthase
Thethe_00334	COG1489	DNA binding
Thethe_00335	COG4224	UPF0291 protein
Thethe_00339	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Thethe_00340	COG2203	Gaf domain
Thethe_00340	COG2199	diguanylate cyclase activity
Thethe_00342	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Thethe_00343	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Thethe_00344	COG0281	malic enzyme
Thethe_00347	COG3880	PFAM UvrB UvrC protein
Thethe_00348	COG3869	Catalyzes the specific phosphorylation of arginine residues in
Thethe_00349	COG0542	response to heat
Thethe_00350	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Thethe_00352	COG4956	integral membrane protein (PIN domain superfamily)
Thethe_00353	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Thethe_00355	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Thethe_00358	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Thethe_00359	COG1045	serine acetyltransferase
Thethe_00360	COG0215	cysteine-tRNA ligase activity
Thethe_00362	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Thethe_00363	COG3688	RNA-binding protein containing a PIN domain
Thethe_00364	COG1595	DNA-templated transcription, initiation
Thethe_00366	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Thethe_00368	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Thethe_00369	COG0250	Participates in transcription elongation, termination and antitermination
Thethe_00370	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Thethe_00373	COG0222	ribosome binding
Thethe_00374	COG0085	RNA polymerase activity
Thethe_00375	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Thethe_00377	COG1358	cellular component organization or biogenesis
Thethe_00378	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Thethe_00379	COG0049	tRNA binding
Thethe_00380	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Thethe_00381	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Thethe_00382	COG0051	transcription antitermination factor activity, RNA binding
Thethe_00383	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Thethe_00384	COG0088	Forms part of the polypeptide exit tunnel
Thethe_00385	COG0089	rRNA binding
Thethe_00386	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Thethe_00387	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Thethe_00388	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Thethe_00389	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Thethe_00390	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Thethe_00391	COG0255	Belongs to the universal ribosomal protein uL29 family
Thethe_00392	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Thethe_00393	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Thethe_00394	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Thethe_00395	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Thethe_00397	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Thethe_00398	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Thethe_00399	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Thethe_00400	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Thethe_00401	COG1841	ribosomal large subunit assembly
Thethe_00402	COG0200	Binds to the 23S rRNA
Thethe_00403	COG0201	protein transport
Thethe_00404	COG0563	adenylate kinase activity
Thethe_00407	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Thethe_00408	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Thethe_00409	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Thethe_00410	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Thethe_00411	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Thethe_00412	COG0202	RNA polymerase activity
Thethe_00413	COG0203	ribosomal protein L17
Thethe_00414	COG1122	ATPase activity
Thethe_00415	COG1122	ATPase activity
Thethe_00416	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Thethe_00417	COG0101	tRNA pseudouridine synthase activity
Thethe_00418	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Thethe_00419	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Thethe_00429	COG1609	Transcriptional regulator
Thethe_00433	COG1175	transmembrane transport
Thethe_00436	COG1621	beta-fructofuranosidase activity
Thethe_00443	COG4974	Belongs to the 'phage' integrase family
Thethe_00444	COG4974	Belongs to the 'phage' integrase family
Thethe_00445	COG4974	Belongs to the 'phage' integrase family
Thethe_00451	COG1349	DNA-binding transcription factor activity
Thethe_00452	COG0434	BtpA family
Thethe_00455	COG1070	Carbohydrate kinase
Thethe_00462	COG3344	reverse transcriptase
Thethe_00465	COG1136	(ABC) transporter
Thethe_00466	COG1136	(ABC) transporter
Thethe_00466	COG0577	efflux transmembrane transporter activity
Thethe_00477	COG0714	Associated with various cellular activities
Thethe_00478	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
Thethe_00479	COG1305	Transglutaminase-like
Thethe_00481	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
Thethe_00489	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Thethe_00491	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Thethe_00492	COG1733	regulation of RNA biosynthetic process
Thethe_00503	COG3464	Transposase
Thethe_00517	COG0454	-acetyltransferase
Thethe_00519	COG0561	phosphatase activity
Thethe_00520	COG2703	oxygen carrier activity
Thethe_00522	COG3973	AAA domain
Thethe_00523	COG0432	Pfam Uncharacterised protein family UPF0047
Thethe_00526	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Thethe_00526	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Thethe_00528	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Thethe_00530	COG2337	Toxic component of a toxin-antitoxin (TA) module
Thethe_00535	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
Thethe_00536	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Thethe_00538	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Thethe_00539	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Thethe_00542	COG3344	reverse transcriptase
Thethe_00543	COG1773	rubredoxin
Thethe_00544	COG0673	inositol 2-dehydrogenase activity
Thethe_00548	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Thethe_00548	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
Thethe_00549	COG3459	Glycosyltransferase 36 associated
Thethe_00550	COG1725	Transcriptional regulator
Thethe_00552	COG4377	Putative membrane peptidase family (DUF2324)
Thethe_00553	COG0330	HflC and HflK could
Thethe_00555	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Thethe_00556	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Thethe_00557	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Thethe_00559	COG0131	Imidazoleglycerol-phosphate dehydratase
Thethe_00560	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Thethe_00563	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Thethe_00563	COG0140	phosphoribosyl-ATP diphosphatase activity
Thethe_00564	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Thethe_00566	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Thethe_00569	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Thethe_00574	COG0640	Transcriptional regulator
Thethe_00578	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Thethe_00579	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Thethe_00580	COG0640	Transcriptional regulator
Thethe_00582	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Thethe_00584	COG0579	oxidoreductase
Thethe_00585	COG0446	pyridine nucleotide-disulphide oxidoreductase
Thethe_00587	COG3829	transcription factor binding
Thethe_00587	COG3290	protein histidine kinase activity
Thethe_00588	COG2376	Dihydroxyacetone kinase
Thethe_00590	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
Thethe_00592	COG0443	Heat shock 70 kDa protein
Thethe_00599	COG0849	cell division
Thethe_00604	COG1131	(ABC) transporter
Thethe_00607	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Thethe_00610	COG3842	ATPase activity
Thethe_00613	COG0437	4 iron, 4 sulfur cluster binding
Thethe_00614	COG0069	glutamate synthase activity
Thethe_00615	COG0067	glutamate synthase
Thethe_00616	COG3835	regulator
Thethe_00617	COG2884	Cell division ATP-binding protein ftsE
Thethe_00618	COG2177	Part of the ABC transporter FtsEX involved in
Thethe_00619	COG0739	heme binding
Thethe_00620	COG0793	Belongs to the peptidase S41A family
Thethe_00621	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Thethe_00622	COG2045	Belongs to the ComB family
Thethe_00623	COG0556	nucleotide-excision repair
Thethe_00625	COG1716	ATPase activity
Thethe_00627	COG0768	penicillin binding
Thethe_00630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Thethe_00632	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Thethe_00632	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Thethe_00633	COG3711	transcriptional antiterminator
Thethe_00634	COG1263	PTS System
Thethe_00634	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Thethe_00634	COG2190	(PTS) system
Thethe_00635	COG2723	6-phospho-beta-galactosidase activity
Thethe_00636	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Thethe_00638	COG1940	carbohydrate kinase activity
Thethe_00639	COG0318	PFAM AMP-dependent synthetase and ligase
Thethe_00641	COG0673	inositol 2-dehydrogenase activity
Thethe_00644	COG0673	inositol 2-dehydrogenase activity
Thethe_00645	COG3250	beta-galactosidase activity
Thethe_00646	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Thethe_00646	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Thethe_00648	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
Thethe_00652	COG2723	6-phospho-beta-galactosidase activity
Thethe_00653	COG3534	alpha-L-arabinofuranosidase
Thethe_00654	COG1653	transport
Thethe_00655	COG1175	transmembrane transport
Thethe_00656	COG0395	ABC-type sugar transport system, permease component
Thethe_00659	COG3507	Belongs to the glycosyl hydrolase 43 family
Thethe_00660	COG2160	L-arabinose isomerase activity
Thethe_00661	COG1069	ribulokinase activity
Thethe_00662	COG0235	Class ii aldolase
Thethe_00664	COG1609	Transcriptional regulator
Thethe_00665	COG0371	Dehydrogenase
Thethe_00670	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
Thethe_00671	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Thethe_00672	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Thethe_00673	COG1940	carbohydrate kinase activity
Thethe_00674	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Thethe_00680	COG1477	protein flavinylation
Thethe_00682	COG0768	penicillin binding
Thethe_00683	COG1793	dna ligase
Thethe_00683	COG3285	dna ligase
Thethe_00684	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
Thethe_00685	COG1388	LysM domain
Thethe_00685	COG0791	NLP P60 protein
Thethe_00686	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Thethe_00689	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Thethe_00689	COG2755	lipolytic protein G-D-S-L family
Thethe_00690	COG0531	amino acid
Thethe_00695	COG2608	mercury ion transmembrane transporter activity
Thethe_00704	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Thethe_00704	COG1796	DNA polymerase
Thethe_00707	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Thethe_00709	COG4942	peptidase
Thethe_00713	COG1914	H( )-stimulated, divalent metal cation uptake system
Thethe_00715	COG2226	methyltransferase
Thethe_00717	COG0785	Cytochrome C biogenesis protein
Thethe_00721	COG3852	Histidine kinase
Thethe_00722	COG2204	response regulator
Thethe_00726	COG2217	Heavy metal translocating P-type atpase
Thethe_00728	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Thethe_00730	COG1660	Displays ATPase and GTPase activities
Thethe_00732	COG1653	transport
Thethe_00736	COG1175	transmembrane transport
Thethe_00737	COG3833	ABC-type maltose transport systems, permease component
Thethe_00740	COG1426	Protein conserved in bacteria
Thethe_00741	COG0366	Alpha amylase catalytic
Thethe_00743	COG1481	regulation of sporulation
Thethe_00744	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thethe_00745	COG4109	DRTGG domain
Thethe_00748	COG0205	6-phosphofructokinase activity
Thethe_00752	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Thethe_00761	COG0778	Nitroreductase
Thethe_00773	COG1199	ATP-dependent helicase activity
Thethe_00775	COG1073	alpha beta
Thethe_00775	COG3064	Membrane
Thethe_00775	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
Thethe_00776	COG2195	Cleaves the N-terminal amino acid of tripeptides
Thethe_00777	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Thethe_00778	COG0778	Nitroreductase
Thethe_00783	COG4656	Part of a membrane complex involved in electron transport
Thethe_00784	COG4658	electron transport chain
Thethe_00785	COG4659	FMN binding
Thethe_00786	COG4660	Part of a membrane complex involved in electron transport
Thethe_00787	COG4657	Part of a membrane complex involved in electron transport
Thethe_00791	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Thethe_00791	COG0646	methionine synthase
Thethe_00792	COG1410	methionine synthase
Thethe_00792	COG0646	methionine synthase
Thethe_00793	COG3546	catalase activity
Thethe_00797	COG1598	PFAM Uncharacterised protein family UPF0150
Thethe_00798	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Thethe_00808	COG0655	NAD(P)H dehydrogenase (quinone) activity
Thethe_00812	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
Thethe_00816	COG0667	Aldo Keto reductase
Thethe_00821	COG0789	Transcriptional regulator
Thethe_00825	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Thethe_00826	COG1234	tRNA 3'-trailer cleavage
Thethe_00827	COG0544	peptidyl-prolyl cis-trans isomerase activity
Thethe_00828	COG0740	serine-type endopeptidase activity
Thethe_00829	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Thethe_00831	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Thethe_00832	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Thethe_00833	COG0356	it plays a direct role in the translocation of protons across the membrane
Thethe_00834	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Thethe_00835	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Thethe_00836	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Thethe_00837	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Thethe_00838	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Thethe_00839	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Thethe_00840	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Thethe_00843	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Thethe_00843	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Thethe_00844	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Thethe_00845	COG1116	anion transmembrane transporter activity
Thethe_00846	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Thethe_00848	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Thethe_00849	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
Thethe_00859	COG0438	transferase activity, transferring glycosyl groups
Thethe_00860	COG1045	serine acetyltransferase
Thethe_00863	COG0438	transferase activity, transferring glycosyl groups
Thethe_00864	COG0110	maltose O-acetyltransferase activity
Thethe_00866	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
Thethe_00868	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Thethe_00869	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Thethe_00873	COG0513	Belongs to the DEAD box helicase family
Thethe_00898	COG1131	(ABC) transporter
Thethe_00902	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thethe_00902	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thethe_00902	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thethe_00903	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thethe_00904	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thethe_00904	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
Thethe_00904	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thethe_00909	COG1879	ABC-type sugar transport system periplasmic component
Thethe_00911	COG1129	ABC transporter
Thethe_00912	COG1172	Belongs to the binding-protein-dependent transport system permease family
Thethe_00927	COG2221	Nitrite and sulphite reductase 4Fe-4S
Thethe_00930	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Thethe_00933	COG1802	Transcriptional regulator
Thethe_00935	COG4209	transmembrane transport
Thethe_00936	COG0395	ABC-type sugar transport system, permease component
Thethe_00940	COG0673	inositol 2-dehydrogenase activity
Thethe_00943	COG3664	PFAM glycoside hydrolase family 39
Thethe_00944	COG3458	cephalosporin-C deacetylase activity
Thethe_00946	COG3275	phosphorelay sensor kinase activity
Thethe_00947	COG1653	transport
Thethe_00948	COG1175	transmembrane transport
Thethe_00949	COG0395	ABC-type sugar transport system, permease component
Thethe_00955	COG1335	isochorismatase
Thethe_00959	COG1136	(ABC) transporter
Thethe_00962	COG1942	4-Oxalocrotonate Tautomerase
Thethe_00967	COG5464	transposase or invertase
Thethe_00970	COG3944	biosynthesis protein
Thethe_00971	COG0489	protein tyrosine kinase activity
Thethe_00972	COG4464	protein tyrosine phosphatase activity
Thethe_00973	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Thethe_00975	COG3344	reverse transcriptase
Thethe_00978	COG3949	Membrane
Thethe_00980	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Thethe_00982	COG0105	UTP biosynthetic process
Thethe_00986	COG0426	domain, Protein
Thethe_00987	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Thethe_00988	COG0671	phosphoesterase, PA-phosphatase related
Thethe_00990	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Thethe_00991	COG1606	tRNA processing
Thethe_00992	COG1691	(AIR) carboxylase
Thethe_00994	COG1268	BioY protein
Thethe_00995	COG0525	valine-tRNA ligase activity
Thethe_00997	COG0285	dihydrofolate synthase activity
Thethe_01004	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Thethe_01006	COG0726	polysaccharide deacetylase
Thethe_01009	COG2171	N-acyltransferase activity
Thethe_01010	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Thethe_01011	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Thethe_01012	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Thethe_01016	COG0745	RESPONSE REGULATOR receiver
Thethe_01016	COG3706	GGDEF domain
Thethe_01019	COG1252	NADH dehydrogenase
Thethe_01022	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Thethe_01023	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Thethe_01026	COG3858	chitin binding
Thethe_01028	COG0739	heme binding
Thethe_01029	COG0438	transferase activity, transferring glycosyl groups
Thethe_01034	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Thethe_01035	COG4475	Protein of unknown function (DUF436)
Thethe_01037	COG1388	LysM domain
Thethe_01037	COG3858	chitin binding
Thethe_01038	COG1983	PspC domain protein
Thethe_01039	COG1113	amino acid transport
Thethe_01041	COG1376	ErfK ybiS ycfS ynhG family protein
Thethe_01042	COG1595	DNA-templated transcription, initiation
Thethe_01045	COG0237	dephospho-CoA kinase activity
Thethe_01046	COG0741	lytic transglycosylase activity
Thethe_01047	COG2707	UPF0756 membrane protein
Thethe_01051	COG0791	NLP P60 protein
Thethe_01053	COG0741	lytic transglycosylase activity
Thethe_01057	COG2878	Part of a membrane complex involved in electron transport
Thethe_01061	COG3290	protein histidine kinase activity
Thethe_01066	COG0424	maF-like protein
Thethe_01067	COG2003	Belongs to the UPF0758 family
Thethe_01068	COG1077	Cell shape determining protein MreB Mrl
Thethe_01072	COG0850	regulation of cytokinetic process
Thethe_01073	COG2894	cell division
Thethe_01074	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Thethe_01075	COG0772	Belongs to the SEDS family
Thethe_01077	COG1388	LysM domain
Thethe_01077	COG0739	heme binding
Thethe_01078	COG0517	IMP dehydrogenase activity
Thethe_01078	COG1994	Peptidase M50
Thethe_01081	COG1530	ribonuclease E activity
Thethe_01082	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Thethe_01084	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Thethe_01086	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Thethe_01087	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Thethe_01088	COG1713	HD superfamily hydrolase involved in NAD metabolism
Thethe_01089	COG0799	negative regulation of ribosome biogenesis
Thethe_01091	COG2964	Protein conserved in bacteria
Thethe_01092	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
Thethe_01093	COG1686	Belongs to the peptidase S11 family
Thethe_01094	COG1555	photosystem II stabilization
Thethe_01094	COG1596	polysaccharide export
Thethe_01096	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Thethe_01097	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Thethe_01098	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Thethe_01103	COG0493	'glutamate synthase
Thethe_01112	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Thethe_01113	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Thethe_01118	COG1131	(ABC) transporter
Thethe_01119	COG1846	Transcriptional regulator
Thethe_01122	COG1234	tRNA 3'-trailer cleavage
Thethe_01123	COG0658	competence protein
Thethe_01123	COG2333	competence protein COMEC
Thethe_01125	COG0268	Binds directly to 16S ribosomal RNA
Thethe_01127	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Thethe_01133	COG0481	GTPase activity
Thethe_01134	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Thethe_01136	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Thethe_01137	COG0443	Heat shock 70 kDa protein
Thethe_01138	COG0484	heat shock protein binding
Thethe_01139	COG2264	protein methyltransferase activity
Thethe_01140	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Thethe_01141	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Thethe_01142	COG0537	adenosine 5'-monophosphoramidase activity
Thethe_01143	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Thethe_01144	COG1610	YqeY-like protein
Thethe_01147	COG1702	phosphate starvation-inducible protein PhoH
Thethe_01148	COG1480	7TM receptor with intracellular HD hydrolase
Thethe_01149	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Thethe_01150	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Thethe_01151	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Thethe_01155	COG0423	glycine-tRNA ligase activity
Thethe_01156	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Thethe_01157	COG0574	Belongs to the PEP-utilizing enzyme family
Thethe_01157	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Thethe_01161	COG0557	exoribonuclease II activity
Thethe_01168	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Thethe_01169	COG1799	cell septum assembly
Thethe_01171	COG2302	S4 RNA-binding domain
Thethe_01172	COG3599	regulation of cell shape
Thethe_01174	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Thethe_01175	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Thethe_01178	COG0512	Glutamine amidotransferase of anthranilate synthase
Thethe_01178	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Thethe_01179	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Thethe_01180	COG0134	indole-3-glycerol-phosphate synthase activity
Thethe_01184	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Thethe_01193	COG0582	viral genome integration into host DNA
Thethe_01200	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Thethe_01202	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Thethe_01203	COG0564	pseudouridine synthase activity
Thethe_01207	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Thethe_01208	COG1937	Protein conserved in bacteria
Thethe_01209	COG3118	belongs to the thioredoxin family
Thethe_01211	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Thethe_01212	COG1959	2 iron, 2 sulfur cluster binding
Thethe_01218	COG1132	(ABC) transporter
Thethe_01227	COG0628	permease
Thethe_01228	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Thethe_01229	COG4472	Bacterial protein of unknown function (DUF965)
Thethe_01231	COG3906	Belongs to the UPF0473 family
Thethe_01232	COG0735	belongs to the Fur family
Thethe_01233	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Thethe_01234	COG3679	Belongs to the UPF0342 family
Thethe_01235	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Thethe_01238	COG0768	penicillin binding
Thethe_01239	COG1191	sigma factor activity
Thethe_01241	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Thethe_01246	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Thethe_01255	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Thethe_01256	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Thethe_01257	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Thethe_01258	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Thethe_01259	COG0006	proline dipeptidase activity
Thethe_01260	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Thethe_01262	COG3854	ATPases associated with a variety of cellular activities
Thethe_01270	COG1302	Protein conserved in bacteria
Thethe_01273	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Thethe_01274	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Thethe_01275	COG1570	exodeoxyribonuclease VII activity
Thethe_01276	COG1722	exodeoxyribonuclease VII activity
Thethe_01277	COG0142	geranyltranstransferase activity
Thethe_01279	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Thethe_01280	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Thethe_01281	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Thethe_01282	COG1438	arginine binding
Thethe_01283	COG0497	DNA recombination
Thethe_01284	COG0750	zinc metalloprotease
Thethe_01292	COG0494	nUDIX hydrolase
Thethe_01293	COG1379	DNA repair
Thethe_01294	COG1300	Membrane
Thethe_01295	COG4974	Belongs to the 'phage' integrase family
Thethe_01296	COG1686	Belongs to the peptidase S11 family
Thethe_01298	COG2172	sigma factor antagonist activity
Thethe_01304	COG0617	tRNA 3'-terminal CCA addition
Thethe_01305	COG1994	Peptidase M50
Thethe_01306	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Thethe_01307	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Thethe_01309	COG3874	Sporulation protein YtfJ
Thethe_01310	COG1686	Belongs to the peptidase S11 family
Thethe_01312	COG0445	tRNA wobble uridine modification
Thethe_01313	COG1187	pseudouridine synthase activity
Thethe_01315	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Thethe_01316	COG0010	Belongs to the arginase family
Thethe_01318	COG1388	LysM domain
Thethe_01320	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Thethe_01322	COG0406	alpha-ribazole phosphatase activity
Thethe_01323	COG2081	HI0933 family
Thethe_01325	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Thethe_01327	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Thethe_01329	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Thethe_01330	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Thethe_01333	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Thethe_01334	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Thethe_01335	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Thethe_01336	COG1923	regulation of RNA biosynthetic process
Thethe_01337	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Thethe_01338	COG0328	RNA-DNA hybrid ribonuclease activity
Thethe_01339	COG4974	Belongs to the 'phage' integrase family
Thethe_01340	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Thethe_01341	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
Thethe_01342	COG0464	growth
Thethe_01343	COG0017	Asparaginyl-tRNA synthetase
Thethe_01344	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Thethe_01346	COG0613	PHP domain protein
Thethe_01347	COG2359	stage V sporulation protein S
Thethe_01348	COG1692	metallophosphoesterase
Thethe_01349	COG1418	mRNA catabolic process
Thethe_01350	COG0419	ATPase involved in DNA repair
Thethe_01351	COG0420	3'-5' exonuclease activity
Thethe_01356	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Thethe_01357	COG1058	Belongs to the CinA family
Thethe_01357	COG1546	Belongs to the CinA family
Thethe_01358	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Thethe_01359	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Thethe_01360	COG1674	ftsk spoiiie
Thethe_01362	COG0740	serine-type endopeptidase activity
Thethe_01363	COG0527	aspartate kinase activity
Thethe_01365	COG0756	dUTP diphosphatase activity
Thethe_01366	COG0612	Peptidase, M16
Thethe_01367	COG0726	polysaccharide deacetylase
Thethe_01368	COG1185	polyribonucleotide nucleotidyltransferase activity
Thethe_01369	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Thethe_01370	COG0196	riboflavin kinase activity
Thethe_01371	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Thethe_01372	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Thethe_01373	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Thethe_01376	COG2740	Nucleic-acid-binding protein implicated in transcription termination
Thethe_01377	COG0195	Participates in both transcription termination and antitermination
Thethe_01378	COG0779	Required for maturation of 30S ribosomal subunits
Thethe_01379	COG2176	DNA-directed DNA polymerase activity
Thethe_01381	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Thethe_01382	COG0750	zinc metalloprotease
Thethe_01383	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Thethe_01384	COG4589	Belongs to the CDS family
Thethe_01385	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Thethe_01387	COG0233	cytoplasmic translational termination
Thethe_01388	COG0528	UMP kinase activity
Thethe_01389	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Thethe_01390	COG0052	Belongs to the universal ribosomal protein uS2 family
Thethe_01393	COG1191	sigma factor activity
Thethe_01394	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Thethe_01395	COG1776	CheC inhibitor of MCP methylation
Thethe_01397	COG2198	Histidine kinase
Thethe_01397	COG0643	Histidine kinase
Thethe_01399	COG0455	bacterial-type flagellum organization
Thethe_01401	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Thethe_01402	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Thethe_01403	COG1684	flagellar biosynthetic protein fliR
Thethe_01404	COG1987	bacterial-type flagellum assembly
Thethe_01405	COG1338	Plays a role in the flagellum-specific transport system
Thethe_01407	COG2201	protein-glutamate methylesterase activity
Thethe_01408	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Thethe_01408	COG1776	CheC inhibitor of MCP methylation
Thethe_01409	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Thethe_01410	COG1580	Controls the rotational direction of flagella during chemotaxis
Thethe_01411	COG1582	Flagellar protein (FlbD)
Thethe_01413	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Thethe_01417	COG1157	protein secretion by the type III secretion system
Thethe_01419	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Thethe_01420	COG1766	The M ring may be actively involved in energy transduction
Thethe_01421	COG1677	Flagellar hook-basal body complex protein FliE
Thethe_01423	COG1815	bacterial-type flagellum-dependent cell motility
Thethe_01425	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Thethe_01426	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Thethe_01427	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Thethe_01428	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Thethe_01428	COG0758	DNA mediated transformation
Thethe_01429	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Thethe_01430	COG0792	nuclease activity
Thethe_01431	COG0180	Tryptophanyl-tRNA synthetase
Thethe_01432	COG0606	chelatase, subunit chli
Thethe_01434	COG0335	large ribosomal subunit rRNA binding
Thethe_01435	COG0336	Belongs to the RNA methyltransferase TrmD family
Thethe_01436	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Thethe_01437	COG1837	Belongs to the UPF0109 family
Thethe_01438	COG0228	four-way junction DNA binding
Thethe_01439	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Thethe_01440	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
Thethe_01447	COG1136	(ABC) transporter
Thethe_01451	COG1595	DNA-templated transcription, initiation
Thethe_01452	COG0552	protein localization to endoplasmic reticulum
Thethe_01453	COG1196	nuclear chromosome segregation
Thethe_01454	COG2359	stage V sporulation protein S
Thethe_01456	COG0571	ribonuclease III activity
Thethe_01457	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Thethe_01458	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Thethe_01460	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Thethe_01461	COG2070	2-Nitropropane dioxygenase
Thethe_01462	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Thethe_01463	COG0416	fatty acid biosynthetic process
Thethe_01464	COG2030	dehydratase
Thethe_01465	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Thethe_01466	COG1399	metal-binding, possibly nucleic acid-binding protein
Thethe_01467	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Thethe_01468	COG0280	phosphate acetyltransferase
Thethe_01470	COG3314	Sporulation integral membrane protein YlbJ
Thethe_01472	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Thethe_01473	COG0742	ribosomal rna small subunit methyltransferase
Thethe_01476	COG1307	EDD domain protein, DegV family
Thethe_01477	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Thethe_01478	COG1461	Dihydroxyacetone kinase
Thethe_01479	COG1302	Protein conserved in bacteria
Thethe_01484	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Thethe_01485	COG1162	GTPase activity
Thethe_01486	COG2815	serine threonine protein kinase
Thethe_01486	COG0515	serine threonine protein kinase
Thethe_01487	COG0631	protein serine/threonine phosphatase activity
Thethe_01488	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Thethe_01489	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Thethe_01489	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Thethe_01490	COG2738	Putative neutral zinc metallopeptidase
Thethe_01492	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Thethe_01493	COG0242	peptide deformylase activity
Thethe_01494	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Thethe_01495	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Thethe_01497	COG0194	GDP metabolic process
Thethe_01499	COG1561	YicC-like family, N-terminal region
Thethe_01500	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Thethe_01508	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Thethe_01509	COG0167	dihydroorotate dehydrogenase activity
Thethe_01510	COG0543	2 iron, 2 sulfur cluster binding
Thethe_01512	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Thethe_01513	COG0540	Belongs to the ATCase OTCase family
Thethe_01514	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Thethe_01517	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Thethe_01519	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Thethe_01520	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Thethe_01521	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Thethe_01521	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Thethe_01524	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Thethe_01525	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Thethe_01531	COG0343	queuine tRNA-ribosyltransferase activity
Thethe_01532	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Thethe_01533	COG2385	sporulation resulting in formation of a cellular spore
Thethe_01533	COG2247	cell wall binding repeat
Thethe_01535	COG2255	four-way junction helicase activity
Thethe_01536	COG0632	four-way junction helicase activity
Thethe_01537	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Thethe_01539	COG0835	chemotaxis
Thethe_01540	COG0217	transcriptional regulatory protein
Thethe_01541	COG0730	response to heat
Thethe_01546	COG1739	Uncharacterized protein family UPF0029
Thethe_01547	COG0494	nUDIX hydrolase
Thethe_01549	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Thethe_01551	COG3344	reverse transcriptase
Thethe_01556	COG0175	sulfate reduction
Thethe_01557	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Thethe_01561	COG0175	sulfate reduction
Thethe_01565	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Thethe_01567	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Thethe_01567	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
Thethe_01570	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Thethe_01572	COG1464	Belongs to the NlpA lipoprotein family
Thethe_01573	COG2011	ABC-type metal ion transport system permease component
Thethe_01574	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Thethe_01575	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Thethe_01579	COG0535	radical SAM domain protein
Thethe_01579	COG1433	Dinitrogenase iron-molybdenum cofactor
Thethe_01584	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Thethe_01586	COG0626	cystathionine gamma-synthase activity
Thethe_01588	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Thethe_01589	COG0626	cystathionine gamma-synthase activity
Thethe_01590	COG2226	methyltransferase
Thethe_01591	COG0113	porphobilinogen synthase activity
Thethe_01592	COG1648	precorrin-2 dehydrogenase activity
Thethe_01592	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Thethe_01593	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Thethe_01595	COG0181	hydroxymethylbilane synthase activity
Thethe_01596	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Thethe_01597	COG4172	Belongs to the ABC transporter superfamily
Thethe_01598	COG0444	Belongs to the ABC transporter superfamily
Thethe_01600	COG0601	transmembrane transport
Thethe_01601	COG4166	transmembrane transport
Thethe_01604	COG1132	(ABC) transporter
Thethe_01610	COG2078	PFAM AMMECR1 domain protein
Thethe_01610	COG3885	ferrous iron binding
Thethe_01611	COG0789	Transcriptional regulator
Thethe_01612	COG0477	Major facilitator Superfamily
Thethe_01613	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Thethe_01614	COG1982	Orn Lys Arg decarboxylase major
Thethe_01616	COG2205	protein histidine kinase activity
Thethe_01617	COG0745	RESPONSE REGULATOR receiver
Thethe_01619	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Thethe_01620	COG0785	Cytochrome C biogenesis protein
Thethe_01621	COG0363	glucosamine-6-phosphate deaminase activity
Thethe_01622	COG1940	carbohydrate kinase activity
Thethe_01625	COG2119	membrane
Thethe_01626	COG3773	Cell wall hydrolase
Thethe_01626	COG3409	Peptidoglycan-binding domain 1 protein
Thethe_01628	COG5002	protein histidine kinase activity
Thethe_01629	COG0745	RESPONSE REGULATOR receiver
Thethe_01630	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Thethe_01631	COG0287	Prephenate dehydrogenase
Thethe_01632	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Thethe_01633	COG0077	Prephenate dehydratase
Thethe_01633	COG1605	Chorismate mutase
Thethe_01634	COG0318	PFAM AMP-dependent synthetase and ligase
Thethe_01635	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Thethe_01636	COG1760	l-serine dehydratase
Thethe_01638	COG1164	Oligoendopeptidase f
Thethe_01640	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Thethe_01641	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Thethe_01643	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Thethe_01646	COG0163	prenyltransferase activity
Thethe_01647	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Thethe_01648	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Thethe_01649	COG0426	domain, Protein
Thethe_01650	COG3069	C4-dicarboxylate transmembrane transporter activity
Thethe_01653	COG1968	undecaprenyl-diphosphatase activity
Thethe_01654	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Thethe_01656	COG0584	glycerophosphoryl diester phosphodiesterase
Thethe_01657	COG1032	radical SAM domain protein
Thethe_01659	COG4086	secreted protein
Thethe_01660	COG3858	chitin binding
Thethe_01661	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
Thethe_01662	COG0427	acetyl-CoA hydrolase
Thethe_01663	COG0183	Belongs to the thiolase family
Thethe_01664	COG1250	3-hydroxyacyl-CoA dehydrogenase
Thethe_01665	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Thethe_01666	COG2086	electron transfer activity
Thethe_01667	COG1960	acyl-CoA dehydrogenase activity
Thethe_01668	COG1024	Enoyl-CoA hydratase
Thethe_01669	COG3875	lactate racemase activity
Thethe_01670	COG0277	FAD linked oxidase domain protein
Thethe_01671	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Thethe_01672	COG2086	electron transfer activity
Thethe_01673	COG1620	l-lactate permease
Thethe_01674	COG2186	Transcriptional regulator
Thethe_01675	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Thethe_01679	COG0561	phosphatase activity
Thethe_01688	COG3964	amidohydrolase
Thethe_01689	COG3711	transcriptional antiterminator
Thethe_01691	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Thethe_01692	COG3457	Alanine racemase
Thethe_01693	COG0626	cystathionine gamma-synthase activity
Thethe_01694	COG1735	metal-dependent hydrolase with the TIM-barrel fold
Thethe_01699	COG2188	Transcriptional regulator
Thethe_01702	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Thethe_01703	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thethe_01703	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thethe_01704	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thethe_01705	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thethe_01705	COG3711	transcriptional antiterminator
Thethe_01720	COG1940	carbohydrate kinase activity
Thethe_01724	COG3940	Belongs to the glycosyl hydrolase 43 family
Thethe_01725	COG3250	beta-galactosidase activity
Thethe_01726	COG0395	ABC-type sugar transport system, permease component
Thethe_01727	COG1175	transmembrane transport
Thethe_01735	COG1063	alcohol dehydrogenase
Thethe_01737	COG0191	fructose-bisphosphate aldolase activity
Thethe_01739	COG3716	PTS system mannose fructose sorbose family IID component
Thethe_01740	COG3715	PTS system
Thethe_01741	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Thethe_01742	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thethe_01742	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Thethe_01743	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Thethe_01743	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Thethe_01758	COG0704	Plays a role in the regulation of phosphate uptake
Thethe_01759	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Thethe_01760	COG0581	inorganic phosphate transmembrane transporter activity
Thethe_01761	COG0573	inorganic phosphate transmembrane transporter activity
Thethe_01762	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Thethe_01763	COG5002	protein histidine kinase activity
Thethe_01764	COG0745	RESPONSE REGULATOR receiver
Thethe_01766	COG1873	PFAM PRC-barrel domain
Thethe_01767	COG1191	sigma factor activity
Thethe_01768	COG1191	sigma factor activity
Thethe_01770	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Thethe_01771	COG0849	cell division
Thethe_01772	COG3856	small basic protein
Thethe_01774	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Thethe_01775	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Thethe_01776	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Thethe_01777	COG0772	Belongs to the SEDS family
Thethe_01779	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Thethe_01780	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Thethe_01781	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Thethe_01782	COG0768	penicillin binding
Thethe_01786	COG0612	Peptidase, M16
Thethe_01787	COG0612	Peptidase, M16
Thethe_01789	COG0012	GTP binding
Thethe_01795	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Thethe_01797	COG1937	Protein conserved in bacteria
Thethe_01798	COG0438	transferase activity, transferring glycosyl groups
Thethe_01802	COG2340	Cysteine-rich secretory protein family
Thethe_01803	COG1362	aminopeptidase activity
Thethe_01804	COG2197	response regulator
Thethe_01809	COG1193	negative regulation of DNA recombination
Thethe_01810	COG0826	peptidase U32
Thethe_01812	COG0072	phenylalanine-tRNA ligase activity
Thethe_01812	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Thethe_01813	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Thethe_01814	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Thethe_01815	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Thethe_01816	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Thethe_01817	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Thethe_01819	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Thethe_01821	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Thethe_01822	COG4399	Belongs to the UPF0754 family
Thethe_01825	COG0745	RESPONSE REGULATOR receiver
Thethe_01828	COG0367	asparagine synthase
Thethe_01829	COG0347	Belongs to the P(II) protein family
Thethe_01832	COG0004	ammonium transporteR
Thethe_01833	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Thethe_01834	COG1691	(AIR) carboxylase
Thethe_01835	COG1606	tRNA processing
Thethe_01840	COG1546	Belongs to the CinA family
Thethe_01840	COG1058	Belongs to the CinA family
Thethe_01842	COG1414	Transcriptional regulator
Thethe_01849	COG0347	Belongs to the P(II) protein family
Thethe_01850	COG0347	Belongs to the P(II) protein family
Thethe_01854	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Thethe_01855	COG1433	Dinitrogenase iron-molybdenum cofactor
Thethe_01855	COG0535	radical SAM domain protein
Thethe_01856	COG0535	radical SAM domain protein
Thethe_01856	COG1433	Dinitrogenase iron-molybdenum cofactor
Thethe_01861	COG0352	thiamine-phosphate diphosphorylase activity
Thethe_01864	COG0352	thiamine-phosphate diphosphorylase activity
Thethe_01864	COG0351	phosphomethylpyrimidine kinase
Thethe_01867	COG1132	(ABC) transporter
Thethe_01869	COG0697	spore germination
Thethe_01870	COG5002	protein histidine kinase activity
Thethe_01876	COG1966	Carbon starvation protein
Thethe_01877	COG3279	Response regulator of the LytR AlgR family
Thethe_01878	COG3275	phosphorelay sensor kinase activity
Thethe_01884	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Thethe_01891	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Thethe_01892	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
Thethe_01897	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Thethe_01898	COG3525	Glycosyl hydrolase, family 20, catalytic domain
Thethe_01901	COG1053	succinate dehydrogenase
Thethe_01903	COG0395	ABC-type sugar transport system, permease component
Thethe_01904	COG1175	transmembrane transport
Thethe_01905	COG1653	transport
Thethe_01906	COG1940	carbohydrate kinase activity
Thethe_01907	COG1737	Transcriptional regulator
Thethe_01908	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
Thethe_01910	COG3387	PFAM Glycoside hydrolase 15-related
Thethe_01911	COG0395	ABC-type sugar transport system, permease component
Thethe_01912	COG1175	transmembrane transport
Thethe_01914	COG1940	carbohydrate kinase activity
Thethe_01917	COG0800	Aldolase
Thethe_01918	COG4948	Mandelate Racemase Muconate Lactonizing
Thethe_01919	COG3775	system Galactitol-specific IIC component
Thethe_01921	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thethe_01922	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Thethe_01922	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Thethe_01926	COG1609	Transcriptional regulator
Thethe_01929	COG0366	Alpha amylase catalytic
Thethe_01930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Thethe_01936	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Thethe_01937	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Thethe_01940	COG1175	transmembrane transport
Thethe_01942	COG1609	Transcriptional regulator
Thethe_01944	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Thethe_01945	COG2942	2-epimerase
Thethe_01949	COG0346	lactoylglutathione lyase activity
Thethe_01952	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Thethe_01954	COG0569	domain protein
Thethe_01955	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Thethe_01958	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Thethe_01960	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Thethe_01961	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Thethe_01963	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Thethe_01965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Thethe_01967	COG5002	protein histidine kinase activity
Thethe_01968	COG0745	RESPONSE REGULATOR receiver
Thethe_01973	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Thethe_01978	COG0367	asparagine synthase
Thethe_01978	COG0367	asparagine synthase
Thethe_01979	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Thethe_01983	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Thethe_01987	COG0390	transport system, permease component
Thethe_01988	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Thethe_01995	COG1533	DNA photolyase activity
Thethe_01996	COG2222	sugar isomerase
Thethe_01997	COG1105	Belongs to the carbohydrate kinase PfkB family
Thethe_01998	COG0191	fructose-bisphosphate aldolase activity
Thethe_01999	COG0546	phosphoglycolate phosphatase activity
Thethe_02000	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Thethe_02003	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Thethe_02003	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thethe_02004	COG3716	PTS system mannose fructose sorbose family IID component
Thethe_02005	COG3715	PTS system
Thethe_02006	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Thethe_02007	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Thethe_02007	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Thethe_02008	COG1278	Cold shock
Thethe_02010	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Thethe_02013	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Thethe_02014	COG1902	pentaerythritol trinitrate reductase activity
Thethe_02016	COG1704	LemA family
Thethe_02017	COG1956	GAF domain-containing protein
Thethe_02018	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Thethe_02026	COG1482	cell wall glycoprotein biosynthetic process
Thethe_02027	COG0813	purine-nucleoside phosphorylase activity
Thethe_02028	COG0482	sulfurtransferase activity
Thethe_02030	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Thethe_02031	COG2384	SAM-dependent methyltransferase
Thethe_02034	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Thethe_02035	COG0358	DNA primase activity
Thethe_02036	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Thethe_02037	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Thethe_02038	COG1342	Belongs to the UPF0251 family
Thethe_02039	COG0148	phosphopyruvate hydratase activity
Thethe_02041	COG0149	triose-phosphate isomerase activity
Thethe_02042	COG0126	phosphoglycerate kinase activity
Thethe_02045	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Thethe_02046	COG1254	Belongs to the acylphosphatase family
Thethe_02047	COG0561	phosphatase activity
Thethe_02048	COG0735	belongs to the Fur family
Thethe_02049	COG2720	vancomycin resistance protein
Thethe_02051	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Thethe_02052	COG1067	ATP-dependent peptidase activity
Thethe_02058	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Thethe_02059	COG1592	Rubrerythrin
Thethe_02059	COG1773	rubredoxin
Thethe_02077	COG0564	pseudouridine synthase activity
Thethe_02081	COG1074	ATP-dependent DNA helicase activity
Thethe_02083	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Thethe_02084	COG1304	FMN binding
Thethe_02085	COG0778	Nitroreductase
Thethe_02087	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Thethe_02089	COG3944	biosynthesis protein
Thethe_02090	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Thethe_02091	COG1511	domain protein
Thethe_02092	COG1309	transcriptional regulator
Thethe_02095	COG0457	Tetratricopeptide repeat
Thethe_02095	COG0463	Glycosyl transferase, family 2
Thethe_02099	COG0840	transmembrane signaling receptor activity
Thethe_02105	COG1752	Esterase of the alpha-beta hydrolase superfamily
Thethe_02107	COG1309	transcriptional regulator
Thethe_02115	COG1454	alcohol dehydrogenase
Thethe_02117	COG2096	Adenosyltransferase
Thethe_02118	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
Thethe_02120	COG4869	propanediol catabolic process
Thethe_02121	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Thethe_02122	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Thethe_02129	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Thethe_02131	COG3344	reverse transcriptase
Thethe_02132	COG2197	response regulator
Thethe_02133	COG1070	Carbohydrate kinase
Thethe_02134	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Thethe_02135	COG1012	belongs to the aldehyde dehydrogenase family
Thethe_02137	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Thethe_02138	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Thethe_02140	COG0613	PHP domain protein
Thethe_02141	COG0698	ribose 5-phosphate isomerase
Thethe_02142	COG3958	Transketolase
Thethe_02143	COG3959	Transketolase, thiamine diphosphate binding domain
Thethe_02156	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Thethe_02157	COG0860	N-Acetylmuramoyl-L-alanine amidase
Thethe_02159	COG4608	Belongs to the ABC transporter superfamily
Thethe_02160	COG0444	Belongs to the ABC transporter superfamily
Thethe_02161	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Thethe_02162	COG0601	transmembrane transport
Thethe_02163	COG4166	transmembrane transport
Thethe_02164	COG4166	transmembrane transport
Thethe_02165	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Thethe_02166	COG0154	amidase activity
Thethe_02167	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Thethe_02168	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Thethe_02170	COG4496	protein, YerC YecD
Thethe_02171	COG1447	Phosphotransferase system cellobiose-specific component IIA
Thethe_02172	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Thethe_02175	COG3711	transcriptional antiterminator
Thethe_02177	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Thethe_02178	COG2011	ABC-type metal ion transport system permease component
Thethe_02180	COG2244	polysaccharide biosynthetic process
Thethe_02184	COG1473	amidohydrolase
Thethe_02186	COG0151	Belongs to the GarS family
Thethe_02187	COG0138	bifunctional purine biosynthesis protein purh
Thethe_02188	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Thethe_02189	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Thethe_02190	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Thethe_02191	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Thethe_02192	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Thethe_02193	COG2252	PERMEase
Thethe_02194	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Thethe_02194	COG0519	Catalyzes the synthesis of GMP from XMP
Thethe_02195	COG0517	IMP dehydrogenase activity
Thethe_02195	COG0516	GMP reductase activity
Thethe_02196	COG0459	protein refolding
Thethe_02202	COG1404	Belongs to the peptidase S8 family
Thethe_02204	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Thethe_02205	COG4120	Belongs to the binding-protein-dependent transport system permease family
Thethe_02208	COG0559	Belongs to the binding-protein-dependent transport system permease family
Thethe_02210	COG0411	ABC transporter
Thethe_02213	COG1132	(ABC) transporter
Thethe_02220	COG1811	Na channel or pump
Thethe_02225	COG1914	H( )-stimulated, divalent metal cation uptake system
Thethe_02227	COG1360	Flagellar Motor Protein
Thethe_02229	COG0488	(ABC) transporter
Thethe_02231	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Thethe_02232	COG0456	acetyltransferase
Thethe_02233	COG1214	PFAM Peptidase M22, glycoprotease
Thethe_02234	COG0802	atpase or kinase
Thethe_02237	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Thethe_02239	COG0398	Pfam SNARE associated Golgi protein
Thethe_02240	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Thethe_02241	COG2183	response to ionizing radiation
Thethe_02243	COG0653	protein targeting
Thethe_02245	COG1827	regulation of RNA biosynthetic process
Thethe_02250	COG1126	abc transporter atp-binding protein
Thethe_02251	COG0765	amino acid transport
Thethe_02252	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Thethe_02255	COG1516	flagellar protein fliS
Thethe_02256	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Thethe_02263	COG1216	Glycosyl transferase, family 2
Thethe_02263	COG0463	Glycosyl transferase, family 2
Thethe_02264	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Thethe_02265	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Thethe_02266	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
Thethe_02268	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Thethe_02269	COG4786	Flagellar basal body rod
Thethe_02269	COG1256	bacterial-type flagellum assembly
Thethe_02273	COG1040	competence protein
Thethe_02274	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Thethe_02276	COG2199	diguanylate cyclase activity
Thethe_02276	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Thethe_02277	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Thethe_02278	COG1592	Rubrerythrin
Thethe_02286	COG3344	reverse transcriptase
Thethe_02288	COG5002	protein histidine kinase activity
Thethe_02289	COG0745	RESPONSE REGULATOR receiver
Thethe_02290	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Thethe_02291	COG1609	Transcriptional regulator
Thethe_02293	COG0561	phosphatase activity
Thethe_02294	COG2323	membrane
Thethe_02301	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Thethe_02303	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Thethe_02305	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Thethe_02307	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Thethe_02308	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Thethe_02309	COG3711	transcriptional antiterminator
Thethe_02310	COG2190	(PTS) system
Thethe_02311	COG1263	PTS System
Thethe_02311	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Thethe_02313	COG0840	transmembrane signaling receptor activity
Thethe_02315	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Thethe_02317	COG2188	Transcriptional regulator
Thethe_02321	COG1744	ABC transporter substrate-binding protein PnrA-like
Thethe_02322	COG3404	Formiminotransferase-cyclodeaminase
Thethe_02332	COG0484	heat shock protein binding
Thethe_02338	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
Thethe_02339	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Thethe_02344	COG1797	cobyrinic acid a,c-diamide synthase activity
Thethe_02345	COG1120	ATPase activity
Thethe_02346	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Thethe_02347	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Thethe_02351	COG5464	transposase or invertase
Thethe_02357	COG5464	transposase or invertase
Thethe_02359	COG1131	(ABC) transporter
Thethe_02364	COG1131	(ABC) transporter
Thethe_02368	COG1136	(ABC) transporter
Thethe_02368	COG0577	efflux transmembrane transporter activity
Thethe_02375	COG0531	amino acid
Thethe_02376	COG0116	Belongs to the methyltransferase superfamily
Thethe_02377	COG2226	methyltransferase
Thethe_02379	COG1522	sequence-specific DNA binding
Thethe_02380	COG0436	Aminotransferase
Thethe_02384	COG0671	phosphoesterase, PA-phosphatase related
Thethe_02386	COG0803	Belongs to the bacterial solute-binding protein 9 family
Thethe_02387	COG1121	(ABC) transporter
Thethe_02388	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Thethe_02394	COG0730	response to heat
Thethe_02395	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Thethe_02396	COG0737	Belongs to the 5'-nucleotidase family
Thethe_02399	COG1263	PTS System
Thethe_02399	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Thethe_02400	COG2190	(PTS) system
Thethe_02401	COG1737	Transcriptional regulator
Thethe_02403	COG1486	melibiose metabolic process
Thethe_02404	COG0673	inositol 2-dehydrogenase activity
Thethe_02407	COG1447	Phosphotransferase system cellobiose-specific component IIA
Thethe_02409	COG2723	6-phospho-beta-galactosidase activity
Thethe_02411	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Thethe_02411	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Thethe_02412	COG0531	amino acid
Thethe_02413	COG4166	transmembrane transport
Thethe_02419	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
Thethe_02420	COG0495	leucyl-tRNA aminoacylation
Thethe_02424	COG0436	Aminotransferase
Thethe_02425	COG4214	carbohydrate transport
Thethe_02427	COG4213	ABC transporter substrate-binding protein
Thethe_02428	COG4213	ABC transporter substrate-binding protein
Thethe_02429	COG2207	Transcriptional regulator
Thethe_02429	COG4753	response regulator
Thethe_02430	COG3275	phosphorelay sensor kinase activity
Thethe_02434	COG1028	Short-chain dehydrogenase reductase Sdr
Thethe_02435	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
Thethe_02436	COG1609	Transcriptional regulator
Thethe_02437	COG0246	Mannitol dehydrogenase
Thethe_02438	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Thethe_02439	COG1070	Carbohydrate kinase
Thethe_02440	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Thethe_02442	COG1349	DNA-binding transcription factor activity
Thethe_02444	COG0534	Mate efflux family protein
Thethe_02445	COG2721	sulfolactate sulfo-lyase activity
Thethe_02446	COG0246	Mannitol dehydrogenase
Thethe_02447	COG1486	melibiose metabolic process
Thethe_02449	COG0395	ABC-type sugar transport system, permease component
Thethe_02450	COG1175	transmembrane transport
Thethe_02452	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
Thethe_02453	COG1609	Transcriptional regulator
Thethe_02454	COG1904	glucuronate isomerase
Thethe_02455	COG1388	LysM domain
Thethe_02455	COG0791	NLP P60 protein
Thethe_02457	COG0493	'glutamate synthase
Thethe_02460	COG0039	L-malate dehydrogenase activity
Thethe_02466	COG0586	Pfam SNARE associated Golgi protein
Thethe_02467	COG0297	glycogen (starch) synthase activity
Thethe_02469	COG1085	galactose-1-phosphate uridylyltransferase
Thethe_02474	COG2723	6-phospho-beta-galactosidase activity
Thethe_02476	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Thethe_02478	COG1447	Phosphotransferase system cellobiose-specific component IIA
Thethe_02479	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thethe_02479	COG3711	transcriptional antiterminator
Thethe_02481	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Thethe_02482	COG2723	6-phospho-beta-galactosidase activity
Thethe_02484	COG1447	Phosphotransferase system cellobiose-specific component IIA
Thethe_02485	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Thethe_02485	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Thethe_02489	COG4716	Myosin-crossreactive antigen
Thethe_02491	COG3875	lactate racemase activity
Thethe_02492	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Thethe_02494	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Thethe_02495	COG2161	toxin-antitoxin pair type II binding
Thethe_02499	COG0534	Mate efflux family protein
Thethe_02500	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Thethe_02502	COG2217	Heavy metal translocating P-type atpase
Thethe_02506	COG1309	transcriptional regulator
Thethe_02509	COG1131	(ABC) transporter
Thethe_02513	COG0864	Transcriptional regulator
Thethe_02514	COG0310	cobalt ion transport
Thethe_02515	COG0310	cobalt ion transport
Thethe_02517	COG1122	ATPase activity
Thethe_02521	COG1595	DNA-templated transcription, initiation
Thethe_02523	COG0205	6-phosphofructokinase activity
Thethe_02524	COG0191	fructose-bisphosphate aldolase activity
Thethe_02525	COG3958	Transketolase
Thethe_02526	COG3959	Transketolase, thiamine diphosphate binding domain
Thethe_02529	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Thethe_02530	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thethe_02531	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Thethe_02533	COG1609	Transcriptional regulator
Thethe_02534	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Thethe_02537	COG1070	Carbohydrate kinase
Thethe_02538	COG2115	Belongs to the xylose isomerase family
Thethe_02540	COG3973	AAA domain
Thethe_02542	COG2267	carboxylic ester hydrolase activity
Thethe_02543	COG0446	pyridine nucleotide-disulphide oxidoreductase
Thethe_02543	COG1902	pentaerythritol trinitrate reductase activity
Thethe_02547	COG4632	Exopolysaccharide biosynthesis protein
Thethe_02547	COG5434	Belongs to the glycosyl hydrolase 28 family
Thethe_02548	COG1979	alcohol dehydrogenase
Thethe_02550	COG0463	Glycosyl transferase, family 2
Thethe_02550	COG0457	Tetratricopeptide repeat
Thethe_02551	COG0840	transmembrane signaling receptor activity
Thethe_02556	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Thethe_02557	COG1132	(ABC) transporter
Thethe_02558	COG1132	(ABC) transporter
Thethe_02561	COG4786	Flagellar basal body rod
Thethe_02563	COG1609	Transcriptional regulator
Thethe_02565	COG2385	sporulation resulting in formation of a cellular spore
Thethe_02573	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Thethe_02574	COG0531	amino acid
Thethe_02576	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Thethe_02578	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Thethe_02579	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Thethe_02581	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Thethe_02582	COG0698	ribose 5-phosphate isomerase
Thethe_02583	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Thethe_02584	COG0009	L-threonylcarbamoyladenylate synthase
Thethe_02586	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Thethe_02587	COG2890	protein-(glutamine-N5) methyltransferase activity
Thethe_02588	COG3872	metal-dependent enzyme
Thethe_02589	COG1435	thymidine kinase activity
Thethe_02590	COG0254	rRNA binding
Thethe_02591	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Thethe_02594	COG0745	RESPONSE REGULATOR receiver
Thethe_02595	COG2247	cell wall binding repeat
Thethe_02595	COG0860	N-Acetylmuramoyl-L-alanine amidase
Thethe_02596	COG3344	reverse transcriptase
Thethe_02598	COG0577	efflux transmembrane transporter activity
Thethe_02598	COG1136	(ABC) transporter
Thethe_02599	COG1136	(ABC) transporter
Thethe_02601	COG1132	(ABC) transporter
Thethe_02602	COG1132	(ABC) transporter
Thethe_02606	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thethe_02606	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thethe_02606	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thethe_02607	COG1105	Belongs to the carbohydrate kinase PfkB family
Thethe_02608	COG1349	DNA-binding transcription factor activity
Thethe_02613	COG1216	Glycosyl transferase, family 2
Thethe_02615	COG0463	Glycosyl transferase, family 2
Thethe_02616	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Thethe_02619	COG5464	transposase or invertase
Thethe_02620	COG2770	Histidine kinase
Thethe_02620	COG2205	protein histidine kinase activity
Thethe_02621	COG0745	RESPONSE REGULATOR receiver
Thethe_02622	COG2373	Large extracellular alpha-helical protein
Thethe_02628	COG0504	CTP synthase activity
Thethe_02629	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Thethe_02634	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Thethe_02635	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Thethe_02636	COG1929	Belongs to the glycerate kinase type-1 family
Thethe_02637	COG3409	Peptidoglycan-binding domain 1 protein
Thethe_02637	COG0793	Belongs to the peptidase S41A family
Thethe_02638	COG0083	homoserine kinase activity
Thethe_02639	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Thethe_02640	COG0460	homoserine dehydrogenase
Thethe_02641	COG4492	Belongs to the UPF0735 family
Thethe_02643	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Thethe_02644	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Thethe_02644	COG0674	pyruvate-flavodoxin oxidoreductase activity
Thethe_02645	COG1013	pyruvate-flavodoxin oxidoreductase activity
Thethe_02646	COG1132	(ABC) transporter
Thethe_02647	COG1132	(ABC) transporter
Thethe_02648	COG1846	Transcriptional regulator
Thethe_02650	COG0038	chloride channel
Thethe_02654	COG1732	Glycine betaine
Thethe_02655	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Thethe_02656	COG1518	maintenance of DNA repeat elements
Thethe_02668	COG1337	RAMP superfamily
Thethe_02675	COG0822	iron-sulfur transferase activity
Thethe_02676	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Thethe_02677	COG0719	Fe-S assembly protein
Thethe_02678	COG0719	Fe-S assembly protein
Thethe_02679	COG0396	ATPase activity
Thethe_02686	COG1012	belongs to the aldehyde dehydrogenase family
Thethe_02686	COG1454	alcohol dehydrogenase
Thethe_02689	COG0667	Aldo Keto reductase
Thethe_02690	COG2211	Major facilitator Superfamily
Thethe_02695	COG1924	4 iron, 4 sulfur cluster binding
Thethe_02702	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Thethe_02711	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Thethe_02712	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Thethe_02716	COG5002	protein histidine kinase activity
Thethe_02717	COG0745	RESPONSE REGULATOR receiver
Thethe_02719	COG0739	heme binding
Thethe_02727	COG5464	transposase or invertase
Thethe_02736	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Thethe_02737	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Thethe_02742	COG3850	Histidine kinase
Thethe_02742	COG5002	protein histidine kinase activity
Thethe_02743	COG0745	RESPONSE REGULATOR receiver
Thethe_02745	COG2239	Acts as a magnesium transporter
Thethe_02748	COG0305	Participates in initiation and elongation during chromosome replication
Thethe_02749	COG0359	binds to the 23S rRNA
Thethe_02750	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
Thethe_02753	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Thethe_02754	COG0629	single-stranded DNA binding
Thethe_02755	COG0360	Binds together with S18 to 16S ribosomal RNA
Thethe_02756	COG4481	Protein conserved in bacteria
Thethe_02757	COG0668	transmembrane transport
Thethe_02760	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Thethe_02760	COG0189	ligase activity
Thethe_02762	COG1597	lipid kinase activity
Thethe_02764	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Thethe_02765	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Thethe_02766	COG1475	DNA binding
Thethe_02767	COG1192	Involved in chromosome partitioning
Thethe_02770	COG0357	Ribosomal RNA small subunit methyltransferase G
Thethe_02771	COG0445	tRNA wobble uridine modification
Thethe_02772	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Thethe_02773	COG1847	R3H domain protein
Thethe_02774	COG0706	membrane insertase activity
Thethe_02775	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Thethe_02776	COG0594	ribonuclease P activity
Thethe_02777	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Thethe_02779	COG4581	dead DEAH box helicase
Thethe_02783	COG2314	TM2 domain
Thethe_02793	COG0539	negative regulation of cytoplasmic translation
Thethe_02827	COG0756	dUTP diphosphatase activity
Thethe_02837	COG0776	regulation of translation
Thethe_02845	COG0629	single-stranded DNA binding
Thethe_02847	COG0592	DNA-directed DNA polymerase activity
Thethe_02857	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Thethe_02864	COG0617	tRNA 3'-terminal CCA addition
Thethe_02888	COG3547	Transposase (IS116 IS110 IS902 family)
Thethe_02902	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Thethe_02918	COG1690	Belongs to the RtcB family