locus-tag	class	description
Thert_00002	COG0582	viral genome integration into host DNA
Thert_00011	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Thert_00015	COG0134	indole-3-glycerol-phosphate synthase activity
Thert_00016	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Thert_00017	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Thert_00017	COG0512	Glutamine amidotransferase of anthranilate synthase
Thert_00020	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Thert_00022	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Thert_00024	COG3599	regulation of cell shape
Thert_00025	COG2302	S4 RNA-binding domain
Thert_00027	COG1799	cell septum assembly
Thert_00028	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Thert_00033	COG0557	exoribonuclease II activity
Thert_00040	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Thert_00040	COG0574	Belongs to the PEP-utilizing enzyme family
Thert_00041	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Thert_00042	COG0423	glycine-tRNA ligase activity
Thert_00046	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Thert_00048	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Thert_00049	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Thert_00050	COG1480	7TM receptor with intracellular HD hydrolase
Thert_00051	COG1702	phosphate starvation-inducible protein PhoH
Thert_00055	COG1610	YqeY-like protein
Thert_00056	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Thert_00057	COG0537	adenosine 5'-monophosphoramidase activity
Thert_00058	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Thert_00059	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Thert_00060	COG2264	protein methyltransferase activity
Thert_00061	COG0484	heat shock protein binding
Thert_00062	COG0443	Heat shock 70 kDa protein
Thert_00064	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Thert_00066	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Thert_00067	COG0481	GTPase activity
Thert_00074	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Thert_00076	COG0268	Binds directly to 16S ribosomal RNA
Thert_00079	COG2333	competence protein COMEC
Thert_00079	COG0658	competence protein
Thert_00080	COG1234	tRNA 3'-trailer cleavage
Thert_00084	COG1131	(ABC) transporter
Thert_00091	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Thert_00092	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Thert_00096	COG0493	'glutamate synthase
Thert_00103	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Thert_00104	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Thert_00105	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Thert_00107	COG1555	photosystem II stabilization
Thert_00107	COG1596	polysaccharide export
Thert_00109	COG1686	Belongs to the peptidase S11 family
Thert_00110	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
Thert_00111	COG2964	Protein conserved in bacteria
Thert_00112	COG0799	negative regulation of ribosome biogenesis
Thert_00113	COG1713	HD superfamily hydrolase involved in NAD metabolism
Thert_00114	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Thert_00115	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Thert_00117	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Thert_00119	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Thert_00120	COG1530	ribonuclease E activity
Thert_00123	COG1994	Peptidase M50
Thert_00123	COG0517	IMP dehydrogenase activity
Thert_00124	COG0739	heme binding
Thert_00124	COG1388	LysM domain
Thert_00126	COG0772	Belongs to the SEDS family
Thert_00127	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Thert_00128	COG2894	cell division
Thert_00129	COG0850	regulation of cytokinetic process
Thert_00133	COG1077	Cell shape determining protein MreB Mrl
Thert_00134	COG2003	Belongs to the UPF0758 family
Thert_00135	COG0424	maF-like protein
Thert_00140	COG3290	protein histidine kinase activity
Thert_00145	COG2878	Part of a membrane complex involved in electron transport
Thert_00149	COG0741	lytic transglycosylase activity
Thert_00151	COG0791	NLP P60 protein
Thert_00156	COG2707	UPF0756 membrane protein
Thert_00157	COG0741	lytic transglycosylase activity
Thert_00158	COG0237	dephospho-CoA kinase activity
Thert_00161	COG1595	DNA-templated transcription, initiation
Thert_00163	COG1376	ErfK ybiS ycfS ynhG family protein
Thert_00168	COG1113	amino acid transport
Thert_00170	COG1983	PspC domain protein
Thert_00172	COG1388	LysM domain
Thert_00172	COG3858	chitin binding
Thert_00175	COG2217	Heavy metal translocating P-type atpase
Thert_00176	COG2217	Heavy metal translocating P-type atpase
Thert_00178	COG4475	Protein of unknown function (DUF436)
Thert_00179	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Thert_00184	COG2340	Cysteine-rich secretory protein family
Thert_00186	COG1362	aminopeptidase activity
Thert_00187	COG2197	response regulator
Thert_00190	COG1193	negative regulation of DNA recombination
Thert_00192	COG0826	peptidase U32
Thert_00195	COG0072	phenylalanine-tRNA ligase activity
Thert_00195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Thert_00196	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Thert_00197	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Thert_00198	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Thert_00199	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Thert_00200	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Thert_00201	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Thert_00204	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Thert_00205	COG4399	Belongs to the UPF0754 family
Thert_00208	COG0745	RESPONSE REGULATOR receiver
Thert_00212	COG0367	asparagine synthase
Thert_00213	COG0347	Belongs to the P(II) protein family
Thert_00214	COG0004	ammonium transporteR
Thert_00220	COG0004	ammonium transporteR
Thert_00225	COG0347	Belongs to the P(II) protein family
Thert_00226	COG0347	Belongs to the P(II) protein family
Thert_00231	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Thert_00235	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Thert_00236	COG1433	Dinitrogenase iron-molybdenum cofactor
Thert_00236	COG0535	radical SAM domain protein
Thert_00237	COG1433	Dinitrogenase iron-molybdenum cofactor
Thert_00237	COG0535	radical SAM domain protein
Thert_00244	COG0352	thiamine-phosphate diphosphorylase activity
Thert_00247	COG0351	phosphomethylpyrimidine kinase
Thert_00247	COG0352	thiamine-phosphate diphosphorylase activity
Thert_00250	COG1132	(ABC) transporter
Thert_00253	COG0697	spore germination
Thert_00254	COG5002	protein histidine kinase activity
Thert_00260	COG1966	Carbon starvation protein
Thert_00261	COG3279	Response regulator of the LytR AlgR family
Thert_00262	COG3275	phosphorelay sensor kinase activity
Thert_00273	COG3973	AAA domain
Thert_00278	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Thert_00279	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
Thert_00286	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Thert_00287	COG3525	Glycosyl hydrolase, family 20, catalytic domain
Thert_00290	COG0445	tRNA wobble uridine modification
Thert_00293	COG0395	ABC-type sugar transport system, permease component
Thert_00294	COG1175	transmembrane transport
Thert_00295	COG1653	transport
Thert_00296	COG1940	carbohydrate kinase activity
Thert_00297	COG1737	Transcriptional regulator
Thert_00298	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
Thert_00300	COG0191	fructose-bisphosphate aldolase activity
Thert_00301	COG1063	alcohol dehydrogenase
Thert_00303	COG3775	system Galactitol-specific IIC component
Thert_00304	COG3414	Phosphotransferase system galactitol-specific IIB component
Thert_00306	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Thert_00306	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Thert_00307	COG0246	Mannitol dehydrogenase
Thert_00309	COG3711	transcriptional antiterminator
Thert_00311	COG2213	PTS system mannitol-specific
Thert_00314	COG1609	Transcriptional regulator
Thert_00318	COG0366	Alpha amylase catalytic
Thert_00319	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Thert_00320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Thert_00323	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Thert_00324	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Thert_00325	COG1874	Beta-galactosidase
Thert_00327	COG1175	transmembrane transport
Thert_00329	COG1609	Transcriptional regulator
Thert_00330	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Thert_00331	COG2942	2-epimerase
Thert_00338	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Thert_00341	COG0569	domain protein
Thert_00342	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Thert_00343	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Thert_00348	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Thert_00350	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Thert_00351	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Thert_00354	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Thert_00356	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Thert_00358	COG5002	protein histidine kinase activity
Thert_00359	COG0745	RESPONSE REGULATOR receiver
Thert_00366	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Thert_00370	COG5002	protein histidine kinase activity
Thert_00372	COG0367	asparagine synthase
Thert_00372	COG0367	asparagine synthase
Thert_00373	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Thert_00382	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Thert_00384	COG0390	transport system, permease component
Thert_00385	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Thert_00386	COG1533	DNA photolyase activity
Thert_00387	COG2222	sugar isomerase
Thert_00388	COG1105	Belongs to the carbohydrate kinase PfkB family
Thert_00389	COG0191	fructose-bisphosphate aldolase activity
Thert_00390	COG0546	phosphoglycolate phosphatase activity
Thert_00393	COG4821	SIS domain
Thert_00398	COG3716	PTS system mannose fructose sorbose family IID component
Thert_00399	COG3715	PTS system
Thert_00400	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Thert_00401	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Thert_00401	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Thert_00402	COG1278	Cold shock
Thert_00403	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Thert_00406	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Thert_00408	COG1902	pentaerythritol trinitrate reductase activity
Thert_00411	COG1704	LemA family
Thert_00412	COG1956	GAF domain-containing protein
Thert_00413	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Thert_00418	COG1482	cell wall glycoprotein biosynthetic process
Thert_00420	COG0813	purine-nucleoside phosphorylase activity
Thert_00421	COG0482	sulfurtransferase activity
Thert_00422	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Thert_00423	COG2384	SAM-dependent methyltransferase
Thert_00424	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Thert_00425	COG0358	DNA primase activity
Thert_00426	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Thert_00427	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Thert_00428	COG1342	Belongs to the UPF0251 family
Thert_00429	COG0148	phosphopyruvate hydratase activity
Thert_00431	COG0149	triose-phosphate isomerase activity
Thert_00432	COG0126	phosphoglycerate kinase activity
Thert_00437	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Thert_00438	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Thert_00439	COG1254	Belongs to the acylphosphatase family
Thert_00440	COG0561	phosphatase activity
Thert_00441	COG0735	belongs to the Fur family
Thert_00442	COG2720	vancomycin resistance protein
Thert_00444	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Thert_00445	COG1067	ATP-dependent peptidase activity
Thert_00451	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Thert_00452	COG1773	rubredoxin
Thert_00452	COG1592	Rubrerythrin
Thert_00481	COG0564	pseudouridine synthase activity
Thert_00485	COG1074	ATP-dependent DNA helicase activity
Thert_00489	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Thert_00491	COG1304	FMN binding
Thert_00492	COG0778	Nitroreductase
Thert_00495	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Thert_00499	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Thert_00501	COG1511	domain protein
Thert_00502	COG1309	transcriptional regulator
Thert_00506	COG0463	Glycosyl transferase, family 2
Thert_00506	COG0457	Tetratricopeptide repeat
Thert_00508	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Thert_00511	COG0840	transmembrane signaling receptor activity
Thert_00517	COG1752	Esterase of the alpha-beta hydrolase superfamily
Thert_00519	COG1309	transcriptional regulator
Thert_00520	COG0622	Phosphoesterase
Thert_00522	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Thert_00524	COG0860	N-Acetylmuramoyl-L-alanine amidase
Thert_00527	COG4608	Belongs to the ABC transporter superfamily
Thert_00528	COG0444	Belongs to the ABC transporter superfamily
Thert_00529	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Thert_00531	COG0601	transmembrane transport
Thert_00532	COG4166	transmembrane transport
Thert_00533	COG4166	transmembrane transport
Thert_00535	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Thert_00536	COG0154	amidase activity
Thert_00537	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Thert_00539	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Thert_00541	COG4496	protein, YerC YecD
Thert_00542	COG1447	Phosphotransferase system cellobiose-specific component IIA
Thert_00543	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Thert_00547	COG3711	transcriptional antiterminator
Thert_00550	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Thert_00552	COG2011	ABC-type metal ion transport system permease component
Thert_00554	COG2244	polysaccharide biosynthetic process
Thert_00558	COG1473	amidohydrolase
Thert_00560	COG0151	Belongs to the GarS family
Thert_00562	COG0138	bifunctional purine biosynthesis protein purh
Thert_00563	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Thert_00564	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Thert_00566	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Thert_00567	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Thert_00568	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Thert_00570	COG2252	PERMEase
Thert_00592	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Thert_00596	COG1396	sequence-specific DNA binding
Thert_00602	COG0519	Catalyzes the synthesis of GMP from XMP
Thert_00602	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Thert_00603	COG0517	IMP dehydrogenase activity
Thert_00603	COG0516	GMP reductase activity
Thert_00605	COG0459	protein refolding
Thert_00614	COG1404	Belongs to the peptidase S8 family
Thert_00616	COG3842	ATPase activity
Thert_00617	COG4120	Belongs to the binding-protein-dependent transport system permease family
Thert_00620	COG0559	Belongs to the binding-protein-dependent transport system permease family
Thert_00623	COG0411	ABC transporter
Thert_00630	COG1132	(ABC) transporter
Thert_00634	COG1811	Na channel or pump
Thert_00640	COG1914	H( )-stimulated, divalent metal cation uptake system
Thert_00642	COG1360	Flagellar Motor Protein
Thert_00645	COG0488	(ABC) transporter
Thert_00647	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Thert_00648	COG0456	acetyltransferase
Thert_00649	COG1214	PFAM Peptidase M22, glycoprotease
Thert_00650	COG0802	atpase or kinase
Thert_00653	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Thert_00655	COG0398	Pfam SNARE associated Golgi protein
Thert_00656	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Thert_00657	COG2183	response to ionizing radiation
Thert_00658	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Thert_00660	COG0653	protein targeting
Thert_00662	COG1827	regulation of RNA biosynthetic process
Thert_00668	COG1126	abc transporter atp-binding protein
Thert_00669	COG0765	amino acid transport
Thert_00670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Thert_00674	COG1516	flagellar protein fliS
Thert_00675	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Thert_00678	COG0632	four-way junction helicase activity
Thert_00681	COG1083	cytidylyl-transferase
Thert_00682	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Thert_00683	COG2089	acid synthase
Thert_00685	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Thert_00687	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Thert_00688	COG1086	Polysaccharide biosynthesis protein
Thert_00689	COG2604	Protein of unknown function DUF115
Thert_00695	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Thert_00696	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Thert_00697	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
Thert_00699	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Thert_00700	COG4786	Flagellar basal body rod
Thert_00700	COG1256	bacterial-type flagellum assembly
Thert_00705	COG1040	competence protein
Thert_00706	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Thert_00708	COG2199	diguanylate cyclase activity
Thert_00708	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Thert_00709	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Thert_00711	COG1592	Rubrerythrin
Thert_00717	COG5002	protein histidine kinase activity
Thert_00718	COG0745	RESPONSE REGULATOR receiver
Thert_00719	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Thert_00720	COG1609	Transcriptional regulator
Thert_00723	COG0561	phosphatase activity
Thert_00724	COG2323	membrane
Thert_00734	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Thert_00736	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Thert_00738	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Thert_00740	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Thert_00742	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Thert_00743	COG3711	transcriptional antiterminator
Thert_00746	COG0840	transmembrane signaling receptor activity
Thert_00749	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Thert_00750	COG0295	cytidine deaminase activity
Thert_00751	COG2188	Transcriptional regulator
Thert_00756	COG1744	ABC transporter substrate-binding protein PnrA-like
Thert_00757	COG3404	Formiminotransferase-cyclodeaminase
Thert_00779	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
Thert_00780	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Thert_00786	COG1797	cobyrinic acid a,c-diamide synthase activity
Thert_00788	COG1120	ATPase activity
Thert_00789	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Thert_00790	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Thert_00795	COG5464	transposase or invertase
Thert_00804	COG1131	(ABC) transporter
Thert_00812	COG0531	amino acid
Thert_00813	COG0116	Belongs to the methyltransferase superfamily
Thert_00816	COG2226	methyltransferase
Thert_00818	COG1522	sequence-specific DNA binding
Thert_00820	COG0436	Aminotransferase
Thert_00825	COG0671	phosphoesterase, PA-phosphatase related
Thert_00827	COG0803	Belongs to the bacterial solute-binding protein 9 family
Thert_00828	COG1121	(ABC) transporter
Thert_00830	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Thert_00833	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Thert_00835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Thert_00841	COG1609	Transcriptional regulator
Thert_00846	COG0730	response to heat
Thert_00847	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Thert_00852	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Thert_00853	COG2971	BadF BadG BcrA BcrD
Thert_00855	COG1472	Belongs to the glycosyl hydrolase 3 family
Thert_00858	COG3876	Protein conserved in bacteria
Thert_00860	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Thert_00861	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
Thert_00862	COG1737	Transcriptional regulator
Thert_00864	COG1737	Transcriptional regulator
Thert_00866	COG1737	Transcriptional regulator
Thert_00872	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Thert_00873	COG1447	Phosphotransferase system cellobiose-specific component IIA
Thert_00877	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Thert_00877	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Thert_00878	COG0531	amino acid
Thert_00879	COG4166	transmembrane transport
Thert_00888	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
Thert_00889	COG0495	leucyl-tRNA aminoacylation
Thert_00896	COG0436	Aminotransferase
Thert_00898	COG4214	carbohydrate transport
Thert_00900	COG4213	ABC transporter substrate-binding protein
Thert_00902	COG4213	ABC transporter substrate-binding protein
Thert_00903	COG4753	response regulator
Thert_00903	COG2207	Transcriptional regulator
Thert_00905	COG3275	phosphorelay sensor kinase activity
Thert_00911	COG4211	Belongs to the binding-protein-dependent transport system permease family
Thert_00914	COG1028	Short-chain dehydrogenase reductase Sdr
Thert_00917	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
Thert_00918	COG1609	Transcriptional regulator
Thert_00921	COG0246	Mannitol dehydrogenase
Thert_00922	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Thert_00923	COG1070	Carbohydrate kinase
Thert_00924	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Thert_00926	COG1349	DNA-binding transcription factor activity
Thert_00928	COG0534	Mate efflux family protein
Thert_00929	COG2721	sulfolactate sulfo-lyase activity
Thert_00930	COG0246	Mannitol dehydrogenase
Thert_00931	COG1486	melibiose metabolic process
Thert_00933	COG0395	ABC-type sugar transport system, permease component
Thert_00934	COG1175	transmembrane transport
Thert_00936	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
Thert_00937	COG1609	Transcriptional regulator
Thert_00938	COG1904	glucuronate isomerase
Thert_00939	COG0791	NLP P60 protein
Thert_00939	COG1388	LysM domain
Thert_00941	COG0493	'glutamate synthase
Thert_00945	COG0039	L-malate dehydrogenase activity
Thert_00953	COG0297	glycogen (starch) synthase activity
Thert_00955	COG1085	galactose-1-phosphate uridylyltransferase
Thert_00968	COG0395	ABC-type sugar transport system, permease component
Thert_00978	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Thert_00979	COG3958	Transketolase
Thert_00980	COG3959	Transketolase, thiamine diphosphate binding domain
Thert_00984	COG1609	Transcriptional regulator
Thert_00986	COG2723	6-phospho-beta-galactosidase activity
Thert_00987	COG0730	response to heat
Thert_00988	COG0641	radical SAM
Thert_00991	COG3119	arylsulfatase activity
Thert_00995	COG3119	arylsulfatase activity
Thert_00996	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Thert_00998	COG1447	Phosphotransferase system cellobiose-specific component IIA
Thert_00999	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Thert_00999	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Thert_01002	COG4716	Myosin-crossreactive antigen
Thert_01005	COG3875	lactate racemase activity
Thert_01006	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Thert_01007	COG0179	Fumarylacetoacetate (FAA) hydrolase
Thert_01008	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Thert_01013	COG0534	Mate efflux family protein
Thert_01015	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Thert_01018	COG2217	Heavy metal translocating P-type atpase
Thert_01022	COG1309	transcriptional regulator
Thert_01025	COG1131	(ABC) transporter
Thert_01028	COG0864	Transcriptional regulator
Thert_01030	COG0310	cobalt ion transport
Thert_01031	COG0310	cobalt ion transport
Thert_01033	COG1122	ATPase activity
Thert_01037	COG1595	DNA-templated transcription, initiation
Thert_01039	COG3958	Transketolase
Thert_01040	COG3959	Transketolase, thiamine diphosphate binding domain
Thert_01041	COG3037	sugar-specific permease SgaT UlaA
Thert_01044	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thert_01045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Thert_01047	COG1609	Transcriptional regulator
Thert_01048	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Thert_01051	COG1070	Carbohydrate kinase
Thert_01052	COG2115	Belongs to the xylose isomerase family
Thert_01055	COG3973	AAA domain
Thert_01057	COG2267	carboxylic ester hydrolase activity
Thert_01059	COG0446	pyridine nucleotide-disulphide oxidoreductase
Thert_01059	COG1902	pentaerythritol trinitrate reductase activity
Thert_01063	COG5434	Belongs to the glycosyl hydrolase 28 family
Thert_01063	COG4632	Exopolysaccharide biosynthesis protein
Thert_01064	COG1979	alcohol dehydrogenase
Thert_01066	COG0457	Tetratricopeptide repeat
Thert_01066	COG0463	Glycosyl transferase, family 2
Thert_01067	COG0840	transmembrane signaling receptor activity
Thert_01072	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Thert_01073	COG1132	(ABC) transporter
Thert_01074	COG1132	(ABC) transporter
Thert_01077	COG4786	Flagellar basal body rod
Thert_01079	COG1609	Transcriptional regulator
Thert_01082	COG2385	sporulation resulting in formation of a cellular spore
Thert_01092	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Thert_01093	COG0531	amino acid
Thert_01095	COG0531	amino acid
Thert_01097	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Thert_01100	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Thert_01102	COG3732	PTS system glucitol sorbitol-specific
Thert_01107	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Thert_01108	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Thert_01110	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Thert_01112	COG0698	ribose 5-phosphate isomerase
Thert_01113	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Thert_01114	COG0009	L-threonylcarbamoyladenylate synthase
Thert_01117	COG2890	protein-(glutamine-N5) methyltransferase activity
Thert_01119	COG3872	metal-dependent enzyme
Thert_01120	COG1435	thymidine kinase activity
Thert_01121	COG0254	rRNA binding
Thert_01122	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Thert_01127	COG0745	RESPONSE REGULATOR receiver
Thert_01128	COG2247	cell wall binding repeat
Thert_01128	COG0860	N-Acetylmuramoyl-L-alanine amidase
Thert_01133	COG1132	(ABC) transporter
Thert_01134	COG1132	(ABC) transporter
Thert_01139	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thert_01139	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thert_01139	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thert_01140	COG1105	Belongs to the carbohydrate kinase PfkB family
Thert_01141	COG1349	DNA-binding transcription factor activity
Thert_01146	COG1216	Glycosyl transferase, family 2
Thert_01148	COG0463	Glycosyl transferase, family 2
Thert_01150	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Thert_01156	COG2205	protein histidine kinase activity
Thert_01156	COG2770	Histidine kinase
Thert_01157	COG0745	RESPONSE REGULATOR receiver
Thert_01158	COG2373	Large extracellular alpha-helical protein
Thert_01170	COG0504	CTP synthase activity
Thert_01173	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Thert_01176	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Thert_01177	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Thert_01178	COG1929	Belongs to the glycerate kinase type-1 family
Thert_01179	COG3409	Peptidoglycan-binding domain 1 protein
Thert_01179	COG0793	Belongs to the peptidase S41A family
Thert_01180	COG0083	homoserine kinase activity
Thert_01183	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Thert_01184	COG0460	homoserine dehydrogenase
Thert_01185	COG4492	Belongs to the UPF0735 family
Thert_01187	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Thert_01189	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Thert_01189	COG0674	pyruvate-flavodoxin oxidoreductase activity
Thert_01190	COG1013	pyruvate-flavodoxin oxidoreductase activity
Thert_01191	COG1132	(ABC) transporter
Thert_01193	COG1846	Transcriptional regulator
Thert_01195	COG0038	chloride channel
Thert_01199	COG1732	Glycine betaine
Thert_01200	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Thert_01201	COG1518	maintenance of DNA repeat elements
Thert_01216	COG1337	RAMP superfamily
Thert_01226	COG0822	iron-sulfur transferase activity
Thert_01227	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Thert_01228	COG0719	Fe-S assembly protein
Thert_01230	COG0719	Fe-S assembly protein
Thert_01238	COG1012	belongs to the aldehyde dehydrogenase family
Thert_01238	COG1454	alcohol dehydrogenase
Thert_01240	COG0667	Aldo Keto reductase
Thert_01245	COG1924	4 iron, 4 sulfur cluster binding
Thert_01251	COG1131	(ABC) transporter
Thert_01265	COG2199	diguanylate cyclase activity
Thert_01265	COG2203	Gaf domain
Thert_01268	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Thert_01269	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Thert_01273	COG5002	protein histidine kinase activity
Thert_01274	COG0745	RESPONSE REGULATOR receiver
Thert_01277	COG0739	heme binding
Thert_01287	COG3464	Transposase
Thert_01292	COG3706	GGDEF domain
Thert_01300	COG5464	transposase or invertase
Thert_01306	COG0358	DNA primase activity
Thert_01313	COG2045	Belongs to the ComB family
Thert_01315	COG5564	TIM-barrel signal transduction protein
Thert_01317	COG5564	TIM-barrel signal transduction protein
Thert_01317	COG2204	response regulator
Thert_01321	COG0732	type I restriction modification DNA specificity domain
Thert_01328	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Thert_01330	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Thert_01337	COG3850	Histidine kinase
Thert_01337	COG5002	protein histidine kinase activity
Thert_01338	COG0745	RESPONSE REGULATOR receiver
Thert_01341	COG2239	Acts as a magnesium transporter
Thert_01343	COG0305	Participates in initiation and elongation during chromosome replication
Thert_01344	COG0359	binds to the 23S rRNA
Thert_01345	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
Thert_01347	COG4241	membrane
Thert_01349	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Thert_01350	COG0629	single-stranded DNA binding
Thert_01351	COG0360	Binds together with S18 to 16S ribosomal RNA
Thert_01353	COG4481	Protein conserved in bacteria
Thert_01354	COG0668	transmembrane transport
Thert_01358	COG0189	ligase activity
Thert_01358	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Thert_01361	COG1597	lipid kinase activity
Thert_01364	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Thert_01365	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Thert_01366	COG1475	DNA binding
Thert_01367	COG1192	Involved in chromosome partitioning
Thert_01370	COG0357	Ribosomal RNA small subunit methyltransferase G
Thert_01371	COG0445	tRNA wobble uridine modification
Thert_01373	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Thert_01375	COG1847	R3H domain protein
Thert_01376	COG0706	membrane insertase activity
Thert_01377	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Thert_01378	COG0594	ribonuclease P activity
Thert_01379	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Thert_01380	COG0592	DNA-directed DNA polymerase activity
Thert_01381	COG2501	S4 domain
Thert_01387	COG0187	DNA topoisomerase II activity
Thert_01388	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Thert_01391	COG0440	acetolactate synthase activity
Thert_01392	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Thert_01393	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Thert_01394	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Thert_01395	COG0066	3-isopropylmalate dehydratase activity
Thert_01396	COG0473	3-isopropylmalate dehydrogenase activity
Thert_01397	COG0129	dihydroxy-acid dehydratase activity
Thert_01398	COG0028	Belongs to the TPP enzyme family
Thert_01409	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Thert_01411	COG1316	TRANSCRIPTIONal
Thert_01412	COG1615	UPF0182 protein
Thert_01417	COG0641	radical SAM
Thert_01432	COG0358	DNA primase activity
Thert_01437	COG0582	viral genome integration into host DNA
Thert_01438	COG0590	tRNA wobble adenosine to inosine editing
Thert_01439	COG2199	diguanylate cyclase activity
Thert_01439	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Thert_01440	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Thert_01442	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Thert_01444	COG0460	homoserine dehydrogenase
Thert_01445	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Thert_01447	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Thert_01456	COG1028	Short-chain dehydrogenase reductase Sdr
Thert_01457	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Thert_01461	COG1187	pseudouridine synthase activity
Thert_01463	COG1882	Formate acetyltransferase
Thert_01465	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Thert_01466	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Thert_01467	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Thert_01469	COG1573	uracil-dna glycosylase
Thert_01473	COG1940	carbohydrate kinase activity
Thert_01474	COG0519	Catalyzes the synthesis of GMP from XMP
Thert_01476	COG1982	Orn Lys Arg decarboxylase major
Thert_01477	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Thert_01478	COG3870	Protein conserved in bacteria
Thert_01482	COG1774	PSP1 C-terminal conserved region
Thert_01484	COG0730	response to heat
Thert_01490	COG2235	arginine
Thert_01491	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Thert_01492	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Thert_01493	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Thert_01494	COG2002	toxin-antitoxin pair type II binding
Thert_01496	COG2715	membrane protein required for spore maturation
Thert_01498	COG0700	Nucleoside recognition
Thert_01501	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Thert_01501	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Thert_01511	COG3063	Type IV pilus biogenesis stability protein PilW
Thert_01516	COG0084	hydrolase, TatD family'
Thert_01519	COG3583	domain protein
Thert_01519	COG3584	3D domain protein
Thert_01520	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Thert_01524	COG0489	protein tyrosine kinase activity
Thert_01533	COG2111	Na H antiporter
Thert_01533	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Thert_01535	COG3260	NADH ubiquinone oxidoreductase 20
Thert_01538	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Thert_01539	COG0375	protein maturation
Thert_01541	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Thert_01542	COG0298	carbon dioxide binding
Thert_01543	COG0409	Hydrogenase expression formation protein
Thert_01545	COG3773	Cell wall hydrolase
Thert_01553	COG1131	(ABC) transporter
Thert_01555	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Thert_01558	COG2221	Nitrite and sulphite reductase 4Fe-4S
Thert_01582	COG0789	Transcriptional regulator
Thert_01583	COG1664	Polymer-forming cytoskeletal
Thert_01585	COG0071	Belongs to the small heat shock protein (HSP20) family
Thert_01587	COG1609	Transcriptional regulator
Thert_01588	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Thert_01589	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Thert_01591	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Thert_01592	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Thert_01594	COG3850	Histidine kinase
Thert_01594	COG5002	protein histidine kinase activity
Thert_01595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Thert_01598	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Thert_01599	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Thert_01602	COG2002	toxin-antitoxin pair type II binding
Thert_01605	COG4466	Protein conserved in bacteria
Thert_01608	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Thert_01609	COG1802	Transcriptional regulator
Thert_01613	COG0697	spore germination
Thert_01615	COG0531	amino acid
Thert_01619	COG1982	Orn Lys Arg decarboxylase major
Thert_01621	COG3773	Cell wall hydrolase
Thert_01621	COG3409	Peptidoglycan-binding domain 1 protein
Thert_01622	COG2959	enzyme of heme biosynthesis
Thert_01624	COG1181	Belongs to the D-alanine--D-alanine ligase family
Thert_01626	COG0018	arginyl-trna synthetase
Thert_01627	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Thert_01628	COG1131	(ABC) transporter
Thert_01630	COG0167	dihydroorotate dehydrogenase activity
Thert_01631	COG0531	amino acid
Thert_01633	COG0667	Aldo Keto reductase
Thert_01636	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Thert_01637	COG3859	Proton-coupled thiamine transporter YuaJ
Thert_01638	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Thert_01639	COG0671	phosphoesterase, PA-phosphatase related
Thert_01647	COG5434	Belongs to the glycosyl hydrolase 28 family
Thert_01647	COG4632	Exopolysaccharide biosynthesis protein
Thert_01648	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Thert_01656	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Thert_01657	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Thert_01659	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Thert_01660	COG0505	Belongs to the CarA family
Thert_01662	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Thert_01664	COG0165	Argininosuccinate lyase
Thert_01668	COG2210	Belongs to the sulfur carrier protein TusA family
Thert_01669	COG0446	pyridine nucleotide-disulphide oxidoreductase
Thert_01670	COG0586	Pfam SNARE associated Golgi protein
Thert_01674	COG2033	superoxide reductase activity
Thert_01675	COG1027	Aspartate ammonia-lyase
Thert_01680	COG3956	TIGRFAM MazG family protein
Thert_01683	COG0776	regulation of translation
Thert_01684	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Thert_01686	COG2385	sporulation resulting in formation of a cellular spore
Thert_01693	COG1098	S1 RNA binding domain
Thert_01694	COG0248	Ppx GppA phosphatase
Thert_01694	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Thert_01705	COG1396	sequence-specific DNA binding
Thert_01725	COG1349	DNA-binding transcription factor activity
Thert_01727	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Thert_01730	COG0205	6-phosphofructokinase activity
Thert_01735	COG3959	Transketolase, thiamine diphosphate binding domain
Thert_01736	COG3958	Transketolase
Thert_01739	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Thert_01740	COG0698	ribose 5-phosphate isomerase
Thert_01741	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Thert_01754	COG3464	Transposase
Thert_01758	COG2267	carboxylic ester hydrolase activity
Thert_01768	COG2801	Transposase and inactivated derivatives
Thert_01773	COG0653	protein targeting
Thert_01776	COG0860	N-Acetylmuramoyl-L-alanine amidase
Thert_01778	COG2233	PERMEase
Thert_01780	COG0842	Transport permease protein
Thert_01781	COG0842	Transport permease protein
Thert_01782	COG1131	(ABC) transporter
Thert_01785	COG1309	transcriptional regulator
Thert_01786	COG1013	pyruvate-flavodoxin oxidoreductase activity
Thert_01786	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Thert_01786	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Thert_01786	COG0674	pyruvate-flavodoxin oxidoreductase activity
Thert_01795	COG1131	(ABC) transporter
Thert_01797	COG1595	DNA-templated transcription, initiation
Thert_01801	COG3830	Belongs to the UPF0237 family
Thert_01803	COG2226	methyltransferase
Thert_01808	COG2226	methyltransferase
Thert_01809	COG2208	phosphoserine phosphatase activity
Thert_01812	COG0037	tRNA processing
Thert_01818	COG3852	Histidine kinase
Thert_01821	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Thert_01823	COG4770	biotin carboxylase activity
Thert_01824	COG4684	Psort location CytoplasmicMembrane, score
Thert_01826	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Thert_01830	COG0697	spore germination
Thert_01836	COG5322	oxidoreductase activity
Thert_01836	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Thert_01837	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Thert_01838	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Thert_01840	COG0302	gtp cyclohydrolase
Thert_01841	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Thert_01842	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Thert_01843	COG0720	synthase
Thert_01844	COG1489	DNA binding
Thert_01845	COG4224	UPF0291 protein
Thert_01848	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Thert_01850	COG2199	diguanylate cyclase activity
Thert_01850	COG2203	Gaf domain
Thert_01852	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thert_01852	COG3711	transcriptional antiterminator
Thert_01853	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thert_01853	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thert_01853	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thert_01854	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thert_01854	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thert_01854	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thert_01855	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thert_01857	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Thert_01858	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Thert_01860	COG0281	malic enzyme
Thert_01863	COG3880	PFAM UvrB UvrC protein
Thert_01864	COG3869	Catalyzes the specific phosphorylation of arginine residues in
Thert_01867	COG0542	response to heat
Thert_01868	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Thert_01870	COG4956	integral membrane protein (PIN domain superfamily)
Thert_01871	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Thert_01873	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Thert_01876	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Thert_01877	COG1045	serine acetyltransferase
Thert_01878	COG0215	cysteine-tRNA ligase activity
Thert_01880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Thert_01881	COG3688	RNA-binding protein containing a PIN domain
Thert_01882	COG1595	DNA-templated transcription, initiation
Thert_01884	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Thert_01885	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Thert_01886	COG0250	Participates in transcription elongation, termination and antitermination
Thert_01887	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Thert_01892	COG0222	ribosome binding
Thert_01895	COG0085	RNA polymerase activity
Thert_01898	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Thert_01899	COG1358	cellular component organization or biogenesis
Thert_01900	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Thert_01901	COG0049	tRNA binding
Thert_01903	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Thert_01905	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Thert_01906	COG0051	transcription antitermination factor activity, RNA binding
Thert_01907	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Thert_01908	COG0088	Forms part of the polypeptide exit tunnel
Thert_01909	COG0089	rRNA binding
Thert_01910	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Thert_01911	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Thert_01912	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Thert_01913	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Thert_01914	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Thert_01915	COG0255	Belongs to the universal ribosomal protein uL29 family
Thert_01916	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Thert_01917	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Thert_01918	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Thert_01919	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Thert_01922	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Thert_01923	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Thert_01924	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Thert_01925	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Thert_01926	COG1841	ribosomal large subunit assembly
Thert_01927	COG0200	Binds to the 23S rRNA
Thert_01928	COG0201	protein transport
Thert_01929	COG0563	adenylate kinase activity
Thert_01932	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Thert_01933	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Thert_01934	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Thert_01935	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Thert_01936	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Thert_01937	COG0202	RNA polymerase activity
Thert_01938	COG0203	ribosomal protein L17
Thert_01939	COG1122	ATPase activity
Thert_01940	COG1122	ATPase activity
Thert_01941	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Thert_01942	COG0101	tRNA pseudouridine synthase activity
Thert_01943	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Thert_01944	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Thert_01950	COG3959	Transketolase, thiamine diphosphate binding domain
Thert_01951	COG3958	Transketolase
Thert_01952	COG0698	ribose 5-phosphate isomerase
Thert_01953	COG0613	PHP domain protein
Thert_01956	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Thert_01960	COG1012	belongs to the aldehyde dehydrogenase family
Thert_01961	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Thert_01962	COG1070	Carbohydrate kinase
Thert_01963	COG2197	response regulator
Thert_01964	COG2972	Histidine kinase
Thert_01966	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Thert_01977	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Thert_01978	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Thert_01979	COG4869	propanediol catabolic process
Thert_01981	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
Thert_01987	COG1454	alcohol dehydrogenase
Thert_01990	COG1737	Transcriptional regulator
Thert_01994	COG1486	melibiose metabolic process
Thert_01995	COG1263	PTS System
Thert_01995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Thert_01995	COG2190	(PTS) system
Thert_01996	COG2190	(PTS) system
Thert_01998	COG1929	Belongs to the glycerate kinase type-1 family
Thert_02002	COG0358	DNA primase activity
Thert_02017	COG0582	viral genome integration into host DNA
Thert_02020	COG1136	(ABC) transporter
Thert_02021	COG1136	(ABC) transporter
Thert_02021	COG0577	efflux transmembrane transporter activity
Thert_02022	COG1454	alcohol dehydrogenase
Thert_02031	COG0860	N-Acetylmuramoyl-L-alanine amidase
Thert_02032	COG0714	Associated with various cellular activities
Thert_02035	COG1305	Transglutaminase-like
Thert_02037	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
Thert_02047	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Thert_02050	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Thert_02077	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Thert_02083	COG1201	RNA secondary structure unwinding
Thert_02089	COG1397	ADP-ribosylglycohydrolase
Thert_02099	COG4974	Belongs to the 'phage' integrase family
Thert_02121	COG2815	serine threonine protein kinase
Thert_02121	COG0515	serine threonine protein kinase
Thert_02124	COG1397	ADP-ribosylglycohydrolase
Thert_02126	COG1396	sequence-specific DNA binding
Thert_02135	COG1733	regulation of RNA biosynthetic process
Thert_02148	COG0454	-acetyltransferase
Thert_02151	COG0561	phosphatase activity
Thert_02153	COG2703	oxygen carrier activity
Thert_02155	COG3973	AAA domain
Thert_02156	COG0432	Pfam Uncharacterised protein family UPF0047
Thert_02160	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Thert_02160	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Thert_02163	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Thert_02165	COG2337	Toxic component of a toxin-antitoxin (TA) module
Thert_02169	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
Thert_02170	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Thert_02172	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Thert_02173	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Thert_02176	COG1773	rubredoxin
Thert_02177	COG0673	inositol 2-dehydrogenase activity
Thert_02181	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
Thert_02181	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Thert_02183	COG3459	Glycosyltransferase 36 associated
Thert_02184	COG1725	Transcriptional regulator
Thert_02186	COG4377	Putative membrane peptidase family (DUF2324)
Thert_02188	COG0330	HflC and HflK could
Thert_02190	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Thert_02191	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Thert_02192	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Thert_02194	COG0131	Imidazoleglycerol-phosphate dehydratase
Thert_02195	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Thert_02199	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Thert_02199	COG0140	phosphoribosyl-ATP diphosphatase activity
Thert_02200	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Thert_02202	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Thert_02207	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Thert_02212	COG0640	Transcriptional regulator
Thert_02216	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Thert_02217	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Thert_02219	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Thert_02220	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Thert_02222	COG0579	oxidoreductase
Thert_02223	COG0446	pyridine nucleotide-disulphide oxidoreductase
Thert_02226	COG3829	transcription factor binding
Thert_02226	COG3290	protein histidine kinase activity
Thert_02227	COG2376	Dihydroxyacetone kinase
Thert_02228	COG1461	Dihydroxyacetone kinase
Thert_02229	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
Thert_02231	COG0443	Heat shock 70 kDa protein
Thert_02239	COG0849	cell division
Thert_02244	COG1131	(ABC) transporter
Thert_02246	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Thert_02250	COG3842	ATPase activity
Thert_02254	COG0437	4 iron, 4 sulfur cluster binding
Thert_02255	COG0069	glutamate synthase activity
Thert_02256	COG0067	glutamate synthase
Thert_02257	COG3835	regulator
Thert_02258	COG2884	Cell division ATP-binding protein ftsE
Thert_02259	COG2177	Part of the ABC transporter FtsEX involved in
Thert_02261	COG0739	heme binding
Thert_02262	COG0793	Belongs to the peptidase S41A family
Thert_02263	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Thert_02264	COG2045	Belongs to the ComB family
Thert_02265	COG0556	nucleotide-excision repair
Thert_02268	COG1716	ATPase activity
Thert_02270	COG0768	penicillin binding
Thert_02272	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Thert_02272	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Thert_02273	COG3711	transcriptional antiterminator
Thert_02274	COG2190	(PTS) system
Thert_02274	COG1263	PTS System
Thert_02274	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Thert_02275	COG2723	6-phospho-beta-galactosidase activity
Thert_02276	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Thert_02278	COG1940	carbohydrate kinase activity
Thert_02279	COG0318	PFAM AMP-dependent synthetase and ligase
Thert_02281	COG0673	inositol 2-dehydrogenase activity
Thert_02286	COG0673	inositol 2-dehydrogenase activity
Thert_02287	COG3250	beta-galactosidase activity
Thert_02289	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Thert_02289	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Thert_02290	COG1447	Phosphotransferase system cellobiose-specific component IIA
Thert_02291	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
Thert_02295	COG2723	6-phospho-beta-galactosidase activity
Thert_02299	COG4209	transmembrane transport
Thert_02300	COG0395	ABC-type sugar transport system, permease component
Thert_02305	COG1874	Beta-galactosidase
Thert_02306	COG1501	Belongs to the glycosyl hydrolase 31 family
Thert_02307	COG3534	alpha-L-arabinofuranosidase
Thert_02310	COG4209	transmembrane transport
Thert_02311	COG0395	ABC-type sugar transport system, permease component
Thert_02316	COG2160	L-arabinose isomerase activity
Thert_02317	COG1069	ribulokinase activity
Thert_02318	COG0235	Class ii aldolase
Thert_02320	COG1609	Transcriptional regulator
Thert_02321	COG0371	Dehydrogenase
Thert_02328	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
Thert_02329	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Thert_02330	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Thert_02332	COG1940	carbohydrate kinase activity
Thert_02333	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Thert_02341	COG1477	protein flavinylation
Thert_02343	COG0768	penicillin binding
Thert_02344	COG1793	dna ligase
Thert_02345	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
Thert_02346	COG0791	NLP P60 protein
Thert_02346	COG1388	LysM domain
Thert_02347	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Thert_02351	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Thert_02351	COG2755	lipolytic protein G-D-S-L family
Thert_02353	COG0531	amino acid
Thert_02360	COG2608	mercury ion transmembrane transporter activity
Thert_02370	COG2211	Major facilitator Superfamily
Thert_02377	COG1609	Transcriptional regulator
Thert_02383	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Thert_02384	COG4209	transmembrane transport
Thert_02386	COG0395	ABC-type sugar transport system, permease component
Thert_02389	COG1621	beta-fructofuranosidase activity
Thert_02404	COG1796	DNA polymerase
Thert_02404	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Thert_02409	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Thert_02411	COG4942	peptidase
Thert_02417	COG1914	H( )-stimulated, divalent metal cation uptake system
Thert_02420	COG2226	methyltransferase
Thert_02422	COG0785	Cytochrome C biogenesis protein
Thert_02426	COG3852	Histidine kinase
Thert_02427	COG2204	response regulator
Thert_02432	COG2217	Heavy metal translocating P-type atpase
Thert_02434	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Thert_02437	COG1660	Displays ATPase and GTPase activities
Thert_02440	COG1653	transport
Thert_02445	COG1175	transmembrane transport
Thert_02447	COG3833	ABC-type maltose transport systems, permease component
Thert_02451	COG1426	Protein conserved in bacteria
Thert_02452	COG0366	Alpha amylase catalytic
Thert_02454	COG1481	regulation of sporulation
Thert_02455	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thert_02456	COG4109	DRTGG domain
Thert_02460	COG0205	6-phosphofructokinase activity
Thert_02465	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Thert_02473	COG1131	(ABC) transporter
Thert_02486	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Thert_02487	COG0745	RESPONSE REGULATOR receiver
Thert_02507	COG1802	Transcriptional regulator
Thert_02507	COG4626	Terminase
Thert_02509	COG4695	Portal protein
Thert_02529	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Thert_02530	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Thert_02535	COG1846	Transcriptional regulator
Thert_02545	COG5632	N-Acetylmuramoyl-L-alanine amidase
Thert_02545	COG3409	Peptidoglycan-binding domain 1 protein
Thert_02551	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Thert_02568	COG0745	RESPONSE REGULATOR receiver
Thert_02569	COG5002	protein histidine kinase activity
Thert_02578	COG1309	transcriptional regulator
Thert_02579	COG0574	Belongs to the PEP-utilizing enzyme family
Thert_02579	COG3848	Pyruvate phosphate dikinase
Thert_02581	COG0574	Belongs to the PEP-utilizing enzyme family
Thert_02581	COG3848	Pyruvate phosphate dikinase
Thert_02582	COG0778	Nitroreductase
Thert_02588	COG1199	ATP-dependent helicase activity
Thert_02590	COG3064	Membrane
Thert_02590	COG1073	alpha beta
Thert_02590	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
Thert_02591	COG2195	Cleaves the N-terminal amino acid of tripeptides
Thert_02592	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Thert_02593	COG0778	Nitroreductase
Thert_02599	COG3275	phosphorelay sensor kinase activity
Thert_02600	COG3279	Response regulator of the LytR AlgR family
Thert_02602	COG1966	Carbon starvation protein
Thert_02603	COG4656	Part of a membrane complex involved in electron transport
Thert_02605	COG4658	electron transport chain
Thert_02607	COG4659	FMN binding
Thert_02608	COG4660	Part of a membrane complex involved in electron transport
Thert_02609	COG4657	Part of a membrane complex involved in electron transport
Thert_02610	COG1245	4Fe-4S binding domain
Thert_02610	COG2878	Part of a membrane complex involved in electron transport
Thert_02615	COG0646	methionine synthase
Thert_02615	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Thert_02617	COG1410	methionine synthase
Thert_02617	COG0646	methionine synthase
Thert_02618	COG3546	catalase activity
Thert_02622	COG1598	PFAM Uncharacterised protein family UPF0150
Thert_02623	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Thert_02626	COG5002	protein histidine kinase activity
Thert_02633	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
Thert_02636	COG0655	NAD(P)H dehydrogenase (quinone) activity
Thert_02640	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Thert_02641	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
Thert_02644	COG0667	Aldo Keto reductase
Thert_02650	COG0789	Transcriptional regulator
Thert_02654	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Thert_02655	COG1234	tRNA 3'-trailer cleavage
Thert_02656	COG0544	peptidyl-prolyl cis-trans isomerase activity
Thert_02657	COG0740	serine-type endopeptidase activity
Thert_02658	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Thert_02662	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Thert_02663	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Thert_02664	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Thert_02665	COG0569	domain protein
Thert_02666	COG0356	it plays a direct role in the translocation of protons across the membrane
Thert_02667	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Thert_02668	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Thert_02669	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Thert_02670	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Thert_02671	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Thert_02672	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Thert_02673	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Thert_02678	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Thert_02678	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Thert_02680	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Thert_02681	COG1116	anion transmembrane transporter activity
Thert_02682	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Thert_02684	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Thert_02685	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
Thert_02699	COG1215	transferase activity, transferring glycosyl groups
Thert_02700	COG0438	transferase activity, transferring glycosyl groups
Thert_02701	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Thert_02703	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Thert_02713	COG0662	Cupin 2, conserved barrel domain protein
Thert_02713	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
Thert_02717	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
Thert_02717	COG0662	Cupin 2, conserved barrel domain protein
Thert_02724	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Thert_02731	COG1078	dGTPase activity
Thert_02732	COG3465	dGTPase activity
Thert_02753	COG2221	Nitrite and sulphite reductase 4Fe-4S
Thert_02760	COG1802	Transcriptional regulator
Thert_02762	COG4209	transmembrane transport
Thert_02763	COG0395	ABC-type sugar transport system, permease component
Thert_02767	COG0673	inositol 2-dehydrogenase activity
Thert_02772	COG3458	cephalosporin-C deacetylase activity
Thert_02773	COG2207	Transcriptional regulator
Thert_02773	COG4753	response regulator
Thert_02773	COG2207	Transcriptional regulator
Thert_02773	COG4753	response regulator
Thert_02774	COG3275	phosphorelay sensor kinase activity
Thert_02778	COG2182	Extracellular solute-binding protein
Thert_02779	COG1653	transport
Thert_02780	COG1175	transmembrane transport
Thert_02781	COG0395	ABC-type sugar transport system, permease component
Thert_02791	COG1942	4-Oxalocrotonate Tautomerase
Thert_02797	COG5464	transposase or invertase
Thert_02800	COG3944	biosynthesis protein
Thert_02801	COG0489	protein tyrosine kinase activity
Thert_02802	COG4464	protein tyrosine phosphatase activity
Thert_02805	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Thert_02811	COG3949	Membrane
Thert_02814	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Thert_02817	COG0105	UTP biosynthetic process
Thert_02822	COG0426	domain, Protein
Thert_02824	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Thert_02826	COG0671	phosphoesterase, PA-phosphatase related
Thert_02828	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Thert_02831	COG1606	tRNA processing
Thert_02832	COG1691	(AIR) carboxylase
Thert_02833	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Thert_02834	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Thert_02835	COG1268	BioY protein
Thert_02836	COG0525	valine-tRNA ligase activity
Thert_02838	COG0285	dihydrofolate synthase activity
Thert_02846	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Thert_02850	COG0395	ABC-type sugar transport system, permease component
Thert_02852	COG2182	Extracellular solute-binding protein
Thert_02856	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Thert_02857	COG0726	polysaccharide deacetylase
Thert_02861	COG2171	N-acyltransferase activity
Thert_02862	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Thert_02863	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Thert_02864	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Thert_02869	COG0745	RESPONSE REGULATOR receiver
Thert_02869	COG3706	GGDEF domain
Thert_02870	COG1181	Belongs to the D-alanine--D-alanine ligase family
Thert_02874	COG1252	NADH dehydrogenase
Thert_02875	COG0446	pyridine nucleotide-disulphide oxidoreductase
Thert_02879	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Thert_02880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Thert_02885	COG3858	chitin binding
Thert_02887	COG0739	heme binding
Thert_02888	COG0438	transferase activity, transferring glycosyl groups
Thert_02897	COG0438	transferase activity, transferring glycosyl groups
Thert_02898	COG1937	Protein conserved in bacteria
Thert_02901	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Thert_02908	COG0012	GTP binding
Thert_02911	COG0612	Peptidase, M16
Thert_02912	COG0612	Peptidase, M16
Thert_02916	COG0768	penicillin binding
Thert_02917	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Thert_02919	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Thert_02920	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Thert_02922	COG0772	Belongs to the SEDS family
Thert_02923	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Thert_02924	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Thert_02926	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Thert_02928	COG3856	small basic protein
Thert_02929	COG0849	cell division
Thert_02930	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Thert_02932	COG1191	sigma factor activity
Thert_02933	COG1191	sigma factor activity
Thert_02934	COG1873	PFAM PRC-barrel domain
Thert_02936	COG0745	RESPONSE REGULATOR receiver
Thert_02937	COG5002	protein histidine kinase activity
Thert_02938	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Thert_02939	COG0573	inorganic phosphate transmembrane transporter activity
Thert_02940	COG0581	inorganic phosphate transmembrane transporter activity
Thert_02941	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Thert_02942	COG0704	Plays a role in the regulation of phosphate uptake
Thert_02956	COG2186	Transcriptional regulator
Thert_02959	COG1620	l-lactate permease
Thert_02961	COG2086	electron transfer activity
Thert_02962	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Thert_02965	COG0277	FAD linked oxidase domain protein
Thert_02966	COG3875	lactate racemase activity
Thert_02970	COG1024	Enoyl-CoA hydratase
Thert_02971	COG1960	acyl-CoA dehydrogenase activity
Thert_02972	COG2086	electron transfer activity
Thert_02973	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Thert_02975	COG1250	3-hydroxyacyl-CoA dehydrogenase
Thert_02977	COG0183	Belongs to the thiolase family
Thert_02978	COG0427	acetyl-CoA hydrolase
Thert_02979	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
Thert_02982	COG3858	chitin binding
Thert_02984	COG4086	secreted protein
Thert_02986	COG1032	radical SAM domain protein
Thert_02987	COG0584	glycerophosphoryl diester phosphodiesterase
Thert_02992	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Thert_02993	COG1968	undecaprenyl-diphosphatase activity
Thert_02997	COG3069	C4-dicarboxylate transmembrane transporter activity
Thert_02999	COG0426	domain, Protein
Thert_03000	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Thert_03004	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Thert_03007	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Thert_03008	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Thert_03010	COG1164	Oligoendopeptidase f
Thert_03012	COG1760	l-serine dehydratase
Thert_03013	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Thert_03014	COG0318	PFAM AMP-dependent synthetase and ligase
Thert_03015	COG1605	Chorismate mutase
Thert_03015	COG0077	Prephenate dehydratase
Thert_03016	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Thert_03017	COG0287	Prephenate dehydrogenase
Thert_03018	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Thert_03019	COG0745	RESPONSE REGULATOR receiver
Thert_03020	COG5002	protein histidine kinase activity
Thert_03022	COG3773	Cell wall hydrolase
Thert_03022	COG3409	Peptidoglycan-binding domain 1 protein
Thert_03023	COG2119	membrane
Thert_03028	COG1940	carbohydrate kinase activity
Thert_03029	COG0363	glucosamine-6-phosphate deaminase activity
Thert_03030	COG0785	Cytochrome C biogenesis protein
Thert_03031	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Thert_03033	COG0745	RESPONSE REGULATOR receiver
Thert_03035	COG2205	protein histidine kinase activity
Thert_03037	COG1982	Orn Lys Arg decarboxylase major
Thert_03040	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Thert_03043	COG0477	Major facilitator Superfamily
Thert_03044	COG0789	Transcriptional regulator
Thert_03045	COG3885	ferrous iron binding
Thert_03045	COG2078	PFAM AMMECR1 domain protein
Thert_03057	COG4166	transmembrane transport
Thert_03058	COG0601	transmembrane transport
Thert_03060	COG0444	Belongs to the ABC transporter superfamily
Thert_03061	COG4172	Belongs to the ABC transporter superfamily
Thert_03062	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Thert_03063	COG0181	hydroxymethylbilane synthase activity
Thert_03066	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Thert_03068	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Thert_03068	COG1648	precorrin-2 dehydrogenase activity
Thert_03069	COG0113	porphobilinogen synthase activity
Thert_03072	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Thert_03076	COG0175	sulfate reduction
Thert_03080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Thert_03081	COG0175	sulfate reduction
Thert_03090	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Thert_03094	COG0494	nUDIX hydrolase
Thert_03095	COG1739	Uncharacterized protein family UPF0029
Thert_03100	COG0730	response to heat
Thert_03102	COG0217	transcriptional regulatory protein
Thert_03103	COG0835	chemotaxis
Thert_03105	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Thert_03106	COG0632	four-way junction helicase activity
Thert_03107	COG2255	four-way junction helicase activity
Thert_03109	COG2385	sporulation resulting in formation of a cellular spore
Thert_03109	COG2247	cell wall binding repeat
Thert_03110	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Thert_03111	COG0343	queuine tRNA-ribosyltransferase activity
Thert_03118	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Thert_03119	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Thert_03124	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Thert_03124	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Thert_03125	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Thert_03126	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Thert_03128	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Thert_03131	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Thert_03132	COG0540	Belongs to the ATCase OTCase family
Thert_03134	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Thert_03136	COG0543	2 iron, 2 sulfur cluster binding
Thert_03137	COG0167	dihydroorotate dehydrogenase activity
Thert_03138	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Thert_03149	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Thert_03150	COG1561	YicC-like family, N-terminal region
Thert_03152	COG0194	GDP metabolic process
Thert_03154	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Thert_03156	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Thert_03157	COG0242	peptide deformylase activity
Thert_03158	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Thert_03160	COG2738	Putative neutral zinc metallopeptidase
Thert_03161	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Thert_03161	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Thert_03162	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Thert_03163	COG0631	protein serine/threonine phosphatase activity
Thert_03165	COG2815	serine threonine protein kinase
Thert_03165	COG0515	serine threonine protein kinase
Thert_03166	COG1162	GTPase activity
Thert_03168	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Thert_03172	COG1302	Protein conserved in bacteria
Thert_03173	COG1461	Dihydroxyacetone kinase
Thert_03174	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Thert_03175	COG1307	EDD domain protein, DegV family
Thert_03182	COG0742	ribosomal rna small subunit methyltransferase
Thert_03183	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Thert_03185	COG3314	Sporulation integral membrane protein YlbJ
Thert_03188	COG0280	phosphate acetyltransferase
Thert_03189	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Thert_03190	COG1399	metal-binding, possibly nucleic acid-binding protein
Thert_03191	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Thert_03192	COG2030	dehydratase
Thert_03193	COG0416	fatty acid biosynthetic process
Thert_03194	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Thert_03196	COG2070	2-Nitropropane dioxygenase
Thert_03197	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Thert_03199	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Thert_03200	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Thert_03201	COG0571	ribonuclease III activity
Thert_03203	COG2359	stage V sporulation protein S
Thert_03205	COG1196	nuclear chromosome segregation
Thert_03206	COG0552	protein localization to endoplasmic reticulum
Thert_03213	COG0577	efflux transmembrane transporter activity
Thert_03213	COG1136	(ABC) transporter
Thert_03216	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
Thert_03217	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Thert_03218	COG0228	four-way junction DNA binding
Thert_03219	COG1837	Belongs to the UPF0109 family
Thert_03220	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Thert_03221	COG0336	Belongs to the RNA methyltransferase TrmD family
Thert_03222	COG0335	large ribosomal subunit rRNA binding
Thert_03224	COG0606	chelatase, subunit chli
Thert_03225	COG0180	Tryptophanyl-tRNA synthetase
Thert_03226	COG0792	nuclease activity
Thert_03227	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Thert_03228	COG0758	DNA mediated transformation
Thert_03228	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Thert_03229	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Thert_03231	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Thert_03232	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Thert_03234	COG1815	bacterial-type flagellum-dependent cell motility
Thert_03238	COG1677	Flagellar hook-basal body complex protein FliE
Thert_03239	COG1766	The M ring may be actively involved in energy transduction
Thert_03240	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Thert_03243	COG1157	protein secretion by the type III secretion system
Thert_03247	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Thert_03249	COG1582	Flagellar protein (FlbD)
Thert_03250	COG1580	Controls the rotational direction of flagella during chemotaxis
Thert_03252	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Thert_03254	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Thert_03254	COG1776	CheC inhibitor of MCP methylation
Thert_03256	COG2201	protein-glutamate methylesterase activity
Thert_03258	COG1338	Plays a role in the flagellum-specific transport system
Thert_03259	COG1987	bacterial-type flagellum assembly
Thert_03261	COG1684	flagellar biosynthetic protein fliR
Thert_03262	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Thert_03263	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Thert_03265	COG0455	bacterial-type flagellum organization
Thert_03268	COG0643	Histidine kinase
Thert_03268	COG2198	Histidine kinase
Thert_03270	COG1776	CheC inhibitor of MCP methylation
Thert_03271	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Thert_03272	COG1191	sigma factor activity
Thert_03275	COG0052	Belongs to the universal ribosomal protein uS2 family
Thert_03276	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Thert_03277	COG0528	UMP kinase activity
Thert_03278	COG0233	cytoplasmic translational termination
Thert_03280	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Thert_03282	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Thert_03283	COG0750	zinc metalloprotease
Thert_03284	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Thert_03289	COG2176	DNA-directed DNA polymerase activity
Thert_03290	COG0779	Required for maturation of 30S ribosomal subunits
Thert_03291	COG0195	Participates in both transcription termination and antitermination
Thert_03292	COG2740	Nucleic-acid-binding protein implicated in transcription termination
Thert_03297	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Thert_03298	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Thert_03299	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Thert_03300	COG0196	riboflavin kinase activity
Thert_03301	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Thert_03303	COG1185	polyribonucleotide nucleotidyltransferase activity
Thert_03304	COG0726	polysaccharide deacetylase
Thert_03305	COG0612	Peptidase, M16
Thert_03306	COG0756	dUTP diphosphatase activity
Thert_03308	COG0527	aspartate kinase activity
Thert_03309	COG0740	serine-type endopeptidase activity
Thert_03313	COG1674	ftsk spoiiie
Thert_03314	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Thert_03316	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Thert_03317	COG1058	Belongs to the CinA family
Thert_03317	COG1546	Belongs to the CinA family
Thert_03318	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Thert_03323	COG0420	3'-5' exonuclease activity
Thert_03324	COG0419	ATPase involved in DNA repair
Thert_03325	COG1418	mRNA catabolic process
Thert_03326	COG1692	metallophosphoesterase
Thert_03327	COG2359	stage V sporulation protein S
Thert_03329	COG0613	PHP domain protein
Thert_03331	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Thert_03332	COG0017	Asparaginyl-tRNA synthetase
Thert_03333	COG0464	growth
Thert_03334	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
Thert_03335	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Thert_03336	COG4974	Belongs to the 'phage' integrase family
Thert_03337	COG0328	RNA-DNA hybrid ribonuclease activity
Thert_03338	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Thert_03339	COG1923	regulation of RNA biosynthetic process
Thert_03340	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Thert_03341	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Thert_03342	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Thert_03343	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Thert_03346	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Thert_03347	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Thert_03349	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Thert_03351	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Thert_03354	COG2081	HI0933 family
Thert_03355	COG0406	alpha-ribazole phosphatase activity
Thert_03357	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Thert_03361	COG0010	Belongs to the arginase family
Thert_03363	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Thert_03365	COG1187	pseudouridine synthase activity
Thert_03366	COG0445	tRNA wobble uridine modification
Thert_03370	COG1686	Belongs to the peptidase S11 family
Thert_03371	COG3874	Sporulation protein YtfJ
Thert_03373	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Thert_03374	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Thert_03375	COG1994	Peptidase M50
Thert_03376	COG0617	tRNA 3'-terminal CCA addition
Thert_03380	COG3360	Dodecin
Thert_03384	COG2172	sigma factor antagonist activity
Thert_03386	COG1686	Belongs to the peptidase S11 family
Thert_03387	COG4974	Belongs to the 'phage' integrase family
Thert_03388	COG1300	Membrane
Thert_03389	COG1379	DNA repair
Thert_03390	COG0494	nUDIX hydrolase
Thert_03399	COG0750	zinc metalloprotease
Thert_03401	COG0497	DNA recombination
Thert_03403	COG1438	arginine binding
Thert_03404	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Thert_03405	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Thert_03406	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Thert_03409	COG0142	geranyltranstransferase activity
Thert_03410	COG1722	exodeoxyribonuclease VII activity
Thert_03411	COG1570	exodeoxyribonuclease VII activity
Thert_03412	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Thert_03413	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Thert_03416	COG1302	Protein conserved in bacteria
Thert_03427	COG3854	ATPases associated with a variety of cellular activities
Thert_03429	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Thert_03430	COG0006	proline dipeptidase activity
Thert_03431	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Thert_03432	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Thert_03433	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Thert_03444	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Thert_03449	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Thert_03451	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Thert_03452	COG1191	sigma factor activity
Thert_03453	COG0768	penicillin binding
Thert_03457	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Thert_03458	COG3679	Belongs to the UPF0342 family
Thert_03459	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Thert_03461	COG0735	belongs to the Fur family
Thert_03462	COG3906	Belongs to the UPF0473 family
Thert_03464	COG4472	Bacterial protein of unknown function (DUF965)
Thert_03465	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Thert_03468	COG0628	permease
Thert_03481	COG1959	2 iron, 2 sulfur cluster binding
Thert_03482	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Thert_03484	COG3118	belongs to the thioredoxin family
Thert_03485	COG1937	Protein conserved in bacteria
Thert_03486	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Thert_03491	COG0564	pseudouridine synthase activity
Thert_03492	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Thert_03494	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Thert_03503	COG0582	viral genome integration into host DNA
Thert_03512	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Thert_03516	COG0135	phosphoribosylanthranilate isomerase activity
Thert_03517	COG0135	phosphoribosylanthranilate isomerase activity
Thert_03518	COG0134	indole-3-glycerol-phosphate synthase activity
Thert_03519	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Thert_03520	COG0512	Glutamine amidotransferase of anthranilate synthase
Thert_03520	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Thert_03521	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia