locus-tag	class	description
Thexy_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Thexy_0002	COG0592	DNA-directed DNA polymerase activity
Thexy_0003	COG2501	S4 domain
Thexy_0006	COG3442	glutamine amidotransferase
Thexy_0008	COG0187	DNA topoisomerase II activity
Thexy_0009	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Thexy_0012	COG0440	acetolactate synthase activity
Thexy_0014	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Thexy_0016	COG0066	3-isopropylmalate dehydratase activity
Thexy_0017	COG0473	3-isopropylmalate dehydrogenase activity
Thexy_0018	COG0129	dihydroxy-acid dehydratase activity
Thexy_0019	COG0028	Belongs to the TPP enzyme family
Thexy_0026	COG0681	Belongs to the peptidase S26 family
Thexy_0027	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Thexy_0028	COG1316	TRANSCRIPTIONal
Thexy_0029	COG1615	UPF0182 protein
Thexy_0032	COG3706	GGDEF domain
Thexy_0034	COG0582	viral genome integration into host DNA
Thexy_0035	COG0840	transmembrane signaling receptor activity
Thexy_0035	COG3290	protein histidine kinase activity
Thexy_0036	COG0835	chemotaxis
Thexy_0037	COG2201	protein-glutamate methylesterase activity
Thexy_0039	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Thexy_0040	COG5001	Diguanylate cyclase
Thexy_0040	COG3300	MHYT domain
Thexy_0042	COG3344	reverse transcriptase
Thexy_0044	COG0590	tRNA wobble adenosine to inosine editing
Thexy_0045	COG2199	diguanylate cyclase activity
Thexy_0045	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Thexy_0046	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Thexy_0047	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Thexy_0048	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Thexy_0049	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Thexy_0050	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Thexy_0051	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Thexy_0057	COG1028	Short-chain dehydrogenase reductase Sdr
Thexy_0058	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Thexy_0061	COG1187	pseudouridine synthase activity
Thexy_0062	COG1882	Formate acetyltransferase
Thexy_0063	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Thexy_0065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Thexy_0066	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Thexy_0068	COG1573	uracil-dna glycosylase
Thexy_0070	COG1940	carbohydrate kinase activity
Thexy_0071	COG0519	Catalyzes the synthesis of GMP from XMP
Thexy_0073	COG1982	Orn Lys Arg decarboxylase major
Thexy_0074	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Thexy_0075	COG3870	Protein conserved in bacteria
Thexy_0077	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Thexy_0078	COG1774	PSP1 C-terminal conserved region
Thexy_0080	COG0730	response to heat
Thexy_0082	COG2235	arginine
Thexy_0083	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Thexy_0084	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Thexy_0085	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Thexy_0086	COG2002	toxin-antitoxin pair type II binding
Thexy_0087	COG2715	membrane protein required for spore maturation
Thexy_0088	COG0700	Nucleoside recognition
Thexy_0090	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Thexy_0090	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Thexy_0091	COG1725	Transcriptional regulator
Thexy_0092	COG1131	(ABC) transporter
Thexy_0095	COG0084	hydrolase, TatD family'
Thexy_0097	COG3584	3D domain protein
Thexy_0097	COG3583	domain protein
Thexy_0098	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Thexy_0101	COG0489	protein tyrosine kinase activity
Thexy_0106	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Thexy_0106	COG2111	Na H antiporter
Thexy_0108	COG3260	NADH ubiquinone oxidoreductase 20
Thexy_0111	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Thexy_0112	COG0375	protein maturation
Thexy_0114	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Thexy_0115	COG0298	carbon dioxide binding
Thexy_0122	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Thexy_0137	COG0789	Transcriptional regulator
Thexy_0138	COG1664	Polymer-forming cytoskeletal
Thexy_0140	COG0071	Belongs to the small heat shock protein (HSP20) family
Thexy_0142	COG1609	Transcriptional regulator
Thexy_0143	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Thexy_0144	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Thexy_0146	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Thexy_0147	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Thexy_0149	COG5002	protein histidine kinase activity
Thexy_0149	COG3850	Histidine kinase
Thexy_0150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Thexy_0153	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Thexy_0154	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Thexy_0155	COG2002	toxin-antitoxin pair type II binding
Thexy_0157	COG4466	Protein conserved in bacteria
Thexy_0159	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Thexy_0160	COG1802	Transcriptional regulator
Thexy_0163	COG0697	spore germination
Thexy_0164	COG0531	amino acid
Thexy_0167	COG1982	Orn Lys Arg decarboxylase major
Thexy_0168	COG3773	Cell wall hydrolase
Thexy_0168	COG3409	Peptidoglycan-binding domain 1 protein
Thexy_0169	COG2959	enzyme of heme biosynthesis
Thexy_0171	COG1438	arginine binding
Thexy_0172	COG0531	amino acid
Thexy_0173	COG2235	arginine
Thexy_0174	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Thexy_0177	COG1438	arginine binding
Thexy_0178	COG1181	Belongs to the D-alanine--D-alanine ligase family
Thexy_0180	COG0018	arginyl-trna synthetase
Thexy_0181	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Thexy_0184	COG0531	amino acid
Thexy_0186	COG0667	Aldo Keto reductase
Thexy_0188	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Thexy_0189	COG3859	Proton-coupled thiamine transporter YuaJ
Thexy_0190	COG3344	reverse transcriptase
Thexy_0191	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Thexy_0192	COG0671	phosphoesterase, PA-phosphatase related
Thexy_0195	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Thexy_0202	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Thexy_0203	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Thexy_0205	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Thexy_0206	COG0505	Belongs to the CarA family
Thexy_0209	COG0165	Argininosuccinate lyase
Thexy_0211	COG0446	pyridine nucleotide-disulphide oxidoreductase
Thexy_0212	COG0586	Pfam SNARE associated Golgi protein
Thexy_0213	COG1321	iron dependent repressor
Thexy_0214	COG1914	H( )-stimulated, divalent metal cation uptake system
Thexy_0215	COG2033	superoxide reductase activity
Thexy_0216	COG1027	Aspartate ammonia-lyase
Thexy_0220	COG3956	TIGRFAM MazG family protein
Thexy_0221	COG0776	regulation of translation
Thexy_0222	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Thexy_0223	COG2385	sporulation resulting in formation of a cellular spore
Thexy_0229	COG1098	S1 RNA binding domain
Thexy_0230	COG0248	Ppx GppA phosphatase
Thexy_0235	COG0860	N-Acetylmuramoyl-L-alanine amidase
Thexy_0237	COG2233	PERMEase
Thexy_0241	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Thexy_0241	COG0674	pyruvate-flavodoxin oxidoreductase activity
Thexy_0241	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Thexy_0241	COG1013	pyruvate-flavodoxin oxidoreductase activity
Thexy_0248	COG2226	methyltransferase
Thexy_0253	COG2226	methyltransferase
Thexy_0254	COG2208	phosphoserine phosphatase activity
Thexy_0256	COG0515	serine threonine protein kinase
Thexy_0256	COG2815	serine threonine protein kinase
Thexy_0257	COG0037	tRNA processing
Thexy_0258	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
Thexy_0258	COG0037	tRNA processing
Thexy_0260	COG4977	sequence-specific DNA binding
Thexy_0260	COG1917	Cupin 2, conserved barrel domain protein
Thexy_0262	COG4191	Histidine kinase
Thexy_0263	COG2759	Belongs to the formate--tetrahydrofolate ligase family
Thexy_0265	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Thexy_0268	COG4684	Psort location CytoplasmicMembrane, score
Thexy_0269	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Thexy_0271	COG0697	spore germination
Thexy_0276	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Thexy_0276	COG5322	oxidoreductase activity
Thexy_0277	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Thexy_0278	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Thexy_0279	COG0302	gtp cyclohydrolase
Thexy_0280	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Thexy_0281	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Thexy_0282	COG0720	synthase
Thexy_0283	COG1489	DNA binding
Thexy_0284	COG4224	UPF0291 protein
Thexy_0288	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Thexy_0289	COG0745	RESPONSE REGULATOR receiver
Thexy_0289	COG3706	GGDEF domain
Thexy_0291	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thexy_0291	COG3711	transcriptional antiterminator
Thexy_0292	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thexy_0292	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thexy_0292	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thexy_0293	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thexy_0293	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thexy_0293	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thexy_0294	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thexy_0295	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Thexy_0296	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Thexy_0297	COG0281	malic enzyme
Thexy_0300	COG3880	PFAM UvrB UvrC protein
Thexy_0301	COG3869	Catalyzes the specific phosphorylation of arginine residues in
Thexy_0302	COG0542	response to heat
Thexy_0303	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Thexy_0305	COG4956	integral membrane protein (PIN domain superfamily)
Thexy_0306	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Thexy_0308	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Thexy_0311	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Thexy_0312	COG1045	serine acetyltransferase
Thexy_0313	COG0215	cysteine-tRNA ligase activity
Thexy_0316	COG3688	RNA-binding protein containing a PIN domain
Thexy_0317	COG1595	DNA-templated transcription, initiation
Thexy_0318	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Thexy_0319	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Thexy_0320	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Thexy_0321	COG0250	Participates in transcription elongation, termination and antitermination
Thexy_0322	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Thexy_0325	COG0222	ribosome binding
Thexy_0326	COG0085	RNA polymerase activity
Thexy_0327	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Thexy_0328	COG1358	cellular component organization or biogenesis
Thexy_0329	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Thexy_0330	COG0049	tRNA binding
Thexy_0331	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Thexy_0332	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Thexy_0333	COG0051	transcription antitermination factor activity, RNA binding
Thexy_0334	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Thexy_0335	COG0088	Forms part of the polypeptide exit tunnel
Thexy_0336	COG0089	rRNA binding
Thexy_0337	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Thexy_0338	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Thexy_0339	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Thexy_0340	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Thexy_0341	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Thexy_0342	COG0255	Belongs to the universal ribosomal protein uL29 family
Thexy_0343	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Thexy_0344	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Thexy_0345	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Thexy_0346	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Thexy_0348	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Thexy_0350	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Thexy_0351	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Thexy_0352	COG1841	ribosomal large subunit assembly
Thexy_0353	COG0200	Binds to the 23S rRNA
Thexy_0354	COG0201	protein transport
Thexy_0355	COG0563	adenylate kinase activity
Thexy_0358	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Thexy_0359	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Thexy_0360	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Thexy_0361	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Thexy_0362	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Thexy_0363	COG0202	RNA polymerase activity
Thexy_0364	COG0203	ribosomal protein L17
Thexy_0365	COG1122	ATPase activity
Thexy_0366	COG1122	ATPase activity
Thexy_0367	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Thexy_0368	COG0101	tRNA pseudouridine synthase activity
Thexy_0369	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Thexy_0370	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Thexy_0372	COG1454	alcohol dehydrogenase
Thexy_0373	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Thexy_0378	COG3942	CHAP domain
Thexy_0378	COG1388	LysM domain
Thexy_0380	COG0714	Associated with various cellular activities
Thexy_0382	COG1305	Transglutaminase-like
Thexy_0384	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
Thexy_0394	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Thexy_0404	COG0454	-acetyltransferase
Thexy_0405	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Thexy_0406	COG0456	acetyltransferase
Thexy_0408	COG0561	phosphatase activity
Thexy_0409	COG2703	oxygen carrier activity
Thexy_0412	COG3973	AAA domain
Thexy_0413	COG0432	Pfam Uncharacterised protein family UPF0047
Thexy_0416	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Thexy_0416	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Thexy_0418	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Thexy_0420	COG2337	Toxic component of a toxin-antitoxin (TA) module
Thexy_0424	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
Thexy_0428	COG3464	Transposase
Thexy_0429	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Thexy_0430	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Thexy_0431	COG0157	Belongs to the NadC ModD family
Thexy_0433	COG1773	rubredoxin
Thexy_0435	COG0673	inositol 2-dehydrogenase activity
Thexy_0437	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
Thexy_0437	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Thexy_0439	COG3459	Glycosyltransferase 36 associated
Thexy_0440	COG1725	Transcriptional regulator
Thexy_0442	COG0330	HflC and HflK could
Thexy_0444	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Thexy_0445	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Thexy_0446	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Thexy_0447	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Thexy_0448	COG0131	Imidazoleglycerol-phosphate dehydratase
Thexy_0449	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Thexy_0452	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Thexy_0452	COG0140	phosphoribosyl-ATP diphosphatase activity
Thexy_0453	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Thexy_0455	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Thexy_0456	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
Thexy_0458	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Thexy_0463	COG0640	Transcriptional regulator
Thexy_0468	COG2814	Major facilitator Superfamily
Thexy_0472	COG1924	4 iron, 4 sulfur cluster binding
Thexy_0473	COG1230	cation diffusion facilitator family transporter
Thexy_0475	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Thexy_0477	COG0798	PFAM Bile acid sodium symporter
Thexy_0480	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Thexy_0481	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Thexy_0482	COG0579	oxidoreductase
Thexy_0483	COG0446	pyridine nucleotide-disulphide oxidoreductase
Thexy_0485	COG3829	transcription factor binding
Thexy_0485	COG3290	protein histidine kinase activity
Thexy_0486	COG2376	Dihydroxyacetone kinase
Thexy_0488	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
Thexy_0490	COG0443	Heat shock 70 kDa protein
Thexy_0497	COG0849	cell division
Thexy_0501	COG1131	(ABC) transporter
Thexy_0505	COG1598	PFAM Uncharacterised protein family UPF0150
Thexy_0506	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Thexy_0509	COG3842	ATPase activity
Thexy_0511	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Thexy_0512	COG0437	4 iron, 4 sulfur cluster binding
Thexy_0513	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Thexy_0513	COG0069	glutamate synthase activity
Thexy_0514	COG0067	glutamate synthase
Thexy_0515	COG3835	regulator
Thexy_0516	COG2884	Cell division ATP-binding protein ftsE
Thexy_0517	COG2177	Part of the ABC transporter FtsEX involved in
Thexy_0518	COG0739	heme binding
Thexy_0519	COG0793	Belongs to the peptidase S41A family
Thexy_0520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Thexy_0521	COG2045	Belongs to the ComB family
Thexy_0522	COG0556	nucleotide-excision repair
Thexy_0524	COG1716	ATPase activity
Thexy_0526	COG0768	penicillin binding
Thexy_0529	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Thexy_0531	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Thexy_0531	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Thexy_0532	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Thexy_0534	COG1940	carbohydrate kinase activity
Thexy_0535	COG0318	PFAM AMP-dependent synthetase and ligase
Thexy_0538	COG0673	inositol 2-dehydrogenase activity
Thexy_0541	COG0673	inositol 2-dehydrogenase activity
Thexy_0542	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Thexy_0542	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Thexy_0543	COG1447	Phosphotransferase system cellobiose-specific component IIA
Thexy_0544	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
Thexy_0548	COG2723	6-phospho-beta-galactosidase activity
Thexy_0549	COG3534	alpha-L-arabinofuranosidase
Thexy_0552	COG1129	ABC transporter
Thexy_0553	COG1172	Belongs to the binding-protein-dependent transport system permease family
Thexy_0554	COG2160	L-arabinose isomerase activity
Thexy_0555	COG1069	ribulokinase activity
Thexy_0556	COG0235	Class ii aldolase
Thexy_0558	COG1609	Transcriptional regulator
Thexy_0559	COG0371	Dehydrogenase
Thexy_0560	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Thexy_0567	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
Thexy_0568	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Thexy_0569	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Thexy_0570	COG1940	carbohydrate kinase activity
Thexy_0575	COG0726	polysaccharide deacetylase
Thexy_0576	COG1477	protein flavinylation
Thexy_0578	COG0768	penicillin binding
Thexy_0579	COG3285	dna ligase
Thexy_0579	COG1793	dna ligase
Thexy_0580	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
Thexy_0582	COG0791	NLP P60 protein
Thexy_0582	COG1388	LysM domain
Thexy_0586	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Thexy_0586	COG2755	lipolytic protein G-D-S-L family
Thexy_0587	COG0531	amino acid
Thexy_0590	COG2608	mercury ion transmembrane transporter activity
Thexy_0592	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Thexy_0595	COG0589	response to stress
Thexy_0601	COG2211	Major facilitator Superfamily
Thexy_0602	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Thexy_0602	COG1796	DNA polymerase
Thexy_0604	COG1914	H( )-stimulated, divalent metal cation uptake system
Thexy_0608	COG2217	Heavy metal translocating P-type atpase
Thexy_0610	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Thexy_0612	COG1660	Displays ATPase and GTPase activities
Thexy_0619	COG0840	transmembrane signaling receptor activity
Thexy_0621	COG1175	transmembrane transport
Thexy_0622	COG3833	ABC-type maltose transport systems, permease component
Thexy_0625	COG1426	Protein conserved in bacteria
Thexy_0626	COG0366	Alpha amylase catalytic
Thexy_0629	COG1481	regulation of sporulation
Thexy_0630	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thexy_0631	COG4109	DRTGG domain
Thexy_0634	COG0205	6-phosphofructokinase activity
Thexy_0638	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Thexy_0645	COG3547	Transposase (IS116 IS110 IS902 family)
Thexy_0649	COG3464	Transposase
Thexy_0650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Thexy_0651	COG0765	amino acid transport
Thexy_0657	COG1827	regulation of RNA biosynthetic process
Thexy_0659	COG0653	protein targeting
Thexy_0661	COG2183	response to ionizing radiation
Thexy_0662	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Thexy_0663	COG0398	Pfam SNARE associated Golgi protein
Thexy_0664	COG3464	Transposase
Thexy_0666	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Thexy_0669	COG0802	atpase or kinase
Thexy_0670	COG1214	PFAM Peptidase M22, glycoprotease
Thexy_0671	COG0456	acetyltransferase
Thexy_0672	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Thexy_0673	COG0488	(ABC) transporter
Thexy_0675	COG1360	Flagellar Motor Protein
Thexy_0677	COG1914	H( )-stimulated, divalent metal cation uptake system
Thexy_0680	COG1811	Na channel or pump
Thexy_0689	COG0411	ABC transporter
Thexy_0691	COG0559	Belongs to the binding-protein-dependent transport system permease family
Thexy_0694	COG4120	Belongs to the binding-protein-dependent transport system permease family
Thexy_0695	COG1136	(ABC) transporter
Thexy_0697	COG1404	Belongs to the peptidase S8 family
Thexy_0705	COG0459	protein refolding
Thexy_0706	COG0517	IMP dehydrogenase activity
Thexy_0706	COG0516	GMP reductase activity
Thexy_0707	COG0519	Catalyzes the synthesis of GMP from XMP
Thexy_0707	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Thexy_0708	COG2252	PERMEase
Thexy_0709	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Thexy_0710	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Thexy_0711	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Thexy_0712	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Thexy_0714	COG0138	bifunctional purine biosynthesis protein purh
Thexy_0715	COG0151	Belongs to the GarS family
Thexy_0716	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Thexy_0717	COG1473	amidohydrolase
Thexy_0719	COG1854	S-ribosylhomocysteine lyase activity
Thexy_0722	COG2011	ABC-type metal ion transport system permease component
Thexy_0723	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Thexy_0724	COG3711	transcriptional antiterminator
Thexy_0727	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Thexy_0728	COG1447	Phosphotransferase system cellobiose-specific component IIA
Thexy_0729	COG4496	protein, YerC YecD
Thexy_0732	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Thexy_0733	COG0154	amidase activity
Thexy_0734	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Thexy_0735	COG4166	transmembrane transport
Thexy_0736	COG4166	transmembrane transport
Thexy_0737	COG0601	transmembrane transport
Thexy_0738	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Thexy_0739	COG0444	Belongs to the ABC transporter superfamily
Thexy_0740	COG4608	Belongs to the ABC transporter superfamily
Thexy_0741	COG0860	N-Acetylmuramoyl-L-alanine amidase
Thexy_0742	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Thexy_0751	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Thexy_0765	COG0457	Tetratricopeptide repeat
Thexy_0765	COG0463	Glycosyl transferase, family 2
Thexy_0767	COG1309	transcriptional regulator
Thexy_0768	COG1511	domain protein
Thexy_0773	COG0778	Nitroreductase
Thexy_0776	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Thexy_0778	COG1074	ATP-dependent DNA helicase activity
Thexy_0779	COG2309	aminopeptidase activity
Thexy_0782	COG0564	pseudouridine synthase activity
Thexy_0792	COG1592	Rubrerythrin
Thexy_0792	COG1773	rubredoxin
Thexy_0793	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Thexy_0794	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Thexy_0794	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Thexy_0797	COG3716	PTS system mannose fructose sorbose family IID component
Thexy_0798	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Thexy_0799	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Thexy_0805	COG1067	ATP-dependent peptidase activity
Thexy_0806	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Thexy_0808	COG2720	vancomycin resistance protein
Thexy_0809	COG0735	belongs to the Fur family
Thexy_0810	COG0561	phosphatase activity
Thexy_0811	COG1254	Belongs to the acylphosphatase family
Thexy_0812	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Thexy_0815	COG0126	phosphoglycerate kinase activity
Thexy_0816	COG0149	triose-phosphate isomerase activity
Thexy_0818	COG0148	phosphopyruvate hydratase activity
Thexy_0820	COG1342	Belongs to the UPF0251 family
Thexy_0821	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Thexy_0822	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Thexy_0823	COG0358	DNA primase activity
Thexy_0824	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Thexy_0825	COG2384	SAM-dependent methyltransferase
Thexy_0826	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Thexy_0827	COG0482	sulfurtransferase activity
Thexy_0828	COG0813	purine-nucleoside phosphorylase activity
Thexy_0829	COG1482	cell wall glycoprotein biosynthetic process
Thexy_0834	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Thexy_0836	COG1704	LemA family
Thexy_0838	COG1902	pentaerythritol trinitrate reductase activity
Thexy_0839	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Thexy_0842	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Thexy_0843	COG1278	Cold shock
Thexy_0844	COG0531	amino acid
Thexy_0845	COG0006	proline dipeptidase activity
Thexy_0847	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Thexy_0849	COG0531	amino acid
Thexy_0854	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Thexy_0857	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Thexy_0859	COG2205	protein histidine kinase activity
Thexy_0860	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
Thexy_0861	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
Thexy_0862	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Thexy_0863	COG5002	protein histidine kinase activity
Thexy_0864	COG0745	RESPONSE REGULATOR receiver
Thexy_0865	COG3706	GGDEF domain
Thexy_0866	COG0726	polysaccharide deacetylase
Thexy_0870	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Thexy_0871	COG0739	heme binding
Thexy_0872	COG0772	Belongs to the SEDS family
Thexy_0874	COG1136	(ABC) transporter
Thexy_0875	COG0577	efflux transmembrane transporter activity
Thexy_0875	COG1136	(ABC) transporter
Thexy_0879	COG0242	peptide deformylase activity
Thexy_0886	COG0425	Belongs to the sulfur carrier protein TusA family
Thexy_0887	COG2391	methyltransferase activity
Thexy_0892	COG0509	glycine decarboxylation via glycine cleavage system
Thexy_0893	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Thexy_0894	COG0446	pyridine nucleotide-disulphide oxidoreductase
Thexy_0895	COG0735	belongs to the Fur family
Thexy_0898	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Thexy_0900	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Thexy_0902	COG0489	protein tyrosine kinase activity
Thexy_0903	COG2894	cell division
Thexy_0905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Thexy_0907	COG0745	RESPONSE REGULATOR receiver
Thexy_0908	COG5002	protein histidine kinase activity
Thexy_0910	COG2814	Major facilitator Superfamily
Thexy_0912	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Thexy_0914	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Thexy_0917	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Thexy_0918	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Thexy_0920	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Thexy_0923	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Thexy_0924	COG0569	domain protein
Thexy_0926	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Thexy_0927	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Thexy_0931	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Thexy_0932	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Thexy_0933	COG2182	Extracellular solute-binding protein
Thexy_0936	COG1621	beta-fructofuranosidase activity
Thexy_0937	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Thexy_0938	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Thexy_0939	COG0366	Alpha amylase catalytic
Thexy_0940	COG1609	Transcriptional regulator
Thexy_0942	COG2213	PTS system mannitol-specific
Thexy_0943	COG3711	transcriptional antiterminator
Thexy_0945	COG0246	Mannitol dehydrogenase
Thexy_0947	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Thexy_0947	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Thexy_0950	COG3414	Phosphotransferase system galactitol-specific IIB component
Thexy_0951	COG3775	system Galactitol-specific IIC component
Thexy_0952	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Thexy_0955	COG4948	Mandelate Racemase Muconate Lactonizing
Thexy_0956	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Thexy_0957	COG0800	Aldolase
Thexy_0964	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Thexy_0968	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
Thexy_0969	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Thexy_0971	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Thexy_0976	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Thexy_0981	COG3275	phosphorelay sensor kinase activity
Thexy_0982	COG3279	Response regulator of the LytR AlgR family
Thexy_0983	COG1966	Carbon starvation protein
Thexy_0989	COG5002	protein histidine kinase activity
Thexy_0990	COG0697	spore germination
Thexy_0991	COG0531	amino acid
Thexy_0997	COG0745	RESPONSE REGULATOR receiver
Thexy_0999	COG1215	transferase activity, transferring glycosyl groups
Thexy_1000	COG0745	RESPONSE REGULATOR receiver
Thexy_1000	COG3706	GGDEF domain
Thexy_1001	COG3464	Transposase
Thexy_1002	COG0352	thiamine-phosphate diphosphorylase activity
Thexy_1002	COG0351	phosphomethylpyrimidine kinase
Thexy_1005	COG0352	thiamine-phosphate diphosphorylase activity
Thexy_1006	COG1533	DNA photolyase activity
Thexy_1009	COG0004	ammonium transporteR
Thexy_1011	COG0004	ammonium transporteR
Thexy_1012	COG0347	Belongs to the P(II) protein family
Thexy_1014	COG0367	asparagine synthase
Thexy_1017	COG0745	RESPONSE REGULATOR receiver
Thexy_1020	COG4399	Belongs to the UPF0754 family
Thexy_1021	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Thexy_1023	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Thexy_1024	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Thexy_1025	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Thexy_1026	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Thexy_1027	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Thexy_1028	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Thexy_1029	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Thexy_1029	COG0072	phenylalanine-tRNA ligase activity
Thexy_1031	COG0826	peptidase U32
Thexy_1032	COG1193	negative regulation of DNA recombination
Thexy_1035	COG2197	response regulator
Thexy_1036	COG1362	aminopeptidase activity
Thexy_1037	COG2340	Cysteine-rich secretory protein family
Thexy_1041	COG3344	reverse transcriptase
Thexy_1042	COG0438	transferase activity, transferring glycosyl groups
Thexy_1043	COG1937	Protein conserved in bacteria
Thexy_1045	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Thexy_1050	COG0301	tRNA thio-modification
Thexy_1051	COG0012	GTP binding
Thexy_1053	COG0612	Peptidase, M16
Thexy_1054	COG0612	Peptidase, M16
Thexy_1058	COG0768	penicillin binding
Thexy_1059	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Thexy_1060	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Thexy_1061	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Thexy_1063	COG0772	Belongs to the SEDS family
Thexy_1064	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Thexy_1065	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Thexy_1068	COG3856	small basic protein
Thexy_1069	COG0849	cell division
Thexy_1070	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Thexy_1072	COG1191	sigma factor activity
Thexy_1073	COG1191	sigma factor activity
Thexy_1074	COG1873	PFAM PRC-barrel domain
Thexy_1076	COG0745	RESPONSE REGULATOR receiver
Thexy_1078	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Thexy_1079	COG0573	inorganic phosphate transmembrane transporter activity
Thexy_1080	COG0581	inorganic phosphate transmembrane transporter activity
Thexy_1081	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Thexy_1082	COG0704	Plays a role in the regulation of phosphate uptake
Thexy_1094	COG0584	glycerophosphoryl diester phosphodiesterase
Thexy_1096	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Thexy_1097	COG1968	undecaprenyl-diphosphatase activity
Thexy_1100	COG3069	C4-dicarboxylate transmembrane transporter activity
Thexy_1101	COG0426	domain, Protein
Thexy_1103	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Thexy_1104	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Thexy_1106	COG1164	Oligoendopeptidase f
Thexy_1108	COG1760	l-serine dehydratase
Thexy_1109	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Thexy_1110	COG0077	Prephenate dehydratase
Thexy_1110	COG1605	Chorismate mutase
Thexy_1111	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Thexy_1112	COG0287	Prephenate dehydrogenase
Thexy_1113	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Thexy_1114	COG0745	RESPONSE REGULATOR receiver
Thexy_1115	COG5002	protein histidine kinase activity
Thexy_1117	COG3773	Cell wall hydrolase
Thexy_1117	COG3409	Peptidoglycan-binding domain 1 protein
Thexy_1118	COG2119	membrane
Thexy_1123	COG1940	carbohydrate kinase activity
Thexy_1124	COG0363	glucosamine-6-phosphate deaminase activity
Thexy_1125	COG0785	Cytochrome C biogenesis protein
Thexy_1126	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Thexy_1127	COG3118	belongs to the thioredoxin family
Thexy_1128	COG0745	RESPONSE REGULATOR receiver
Thexy_1129	COG2205	protein histidine kinase activity
Thexy_1131	COG1982	Orn Lys Arg decarboxylase major
Thexy_1132	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Thexy_1133	COG0477	Major facilitator Superfamily
Thexy_1134	COG0789	Transcriptional regulator
Thexy_1136	COG3885	ferrous iron binding
Thexy_1136	COG2078	PFAM AMMECR1 domain protein
Thexy_1140	COG0628	permease
Thexy_1141	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Thexy_1142	COG4472	Bacterial protein of unknown function (DUF965)
Thexy_1144	COG3906	Belongs to the UPF0473 family
Thexy_1145	COG0735	belongs to the Fur family
Thexy_1146	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Thexy_1147	COG3679	Belongs to the UPF0342 family
Thexy_1148	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Thexy_1151	COG0768	penicillin binding
Thexy_1152	COG1191	sigma factor activity
Thexy_1154	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Thexy_1159	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Thexy_1169	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Thexy_1170	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Thexy_1171	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Thexy_1172	COG0006	proline dipeptidase activity
Thexy_1173	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Thexy_1175	COG3854	ATPases associated with a variety of cellular activities
Thexy_1183	COG1302	Protein conserved in bacteria
Thexy_1184	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Thexy_1185	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Thexy_1186	COG1570	exodeoxyribonuclease VII activity
Thexy_1187	COG1722	exodeoxyribonuclease VII activity
Thexy_1190	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Thexy_1191	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Thexy_1192	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Thexy_1193	COG1438	arginine binding
Thexy_1194	COG0497	DNA recombination
Thexy_1195	COG0750	zinc metalloprotease
Thexy_1202	COG0494	nUDIX hydrolase
Thexy_1203	COG1379	DNA repair
Thexy_1204	COG1300	Membrane
Thexy_1205	COG4974	Belongs to the 'phage' integrase family
Thexy_1206	COG1686	Belongs to the peptidase S11 family
Thexy_1208	COG2172	sigma factor antagonist activity
Thexy_1211	COG3360	Dodecin
Thexy_1215	COG0617	tRNA 3'-terminal CCA addition
Thexy_1216	COG1994	Peptidase M50
Thexy_1217	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Thexy_1218	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Thexy_1220	COG3874	Sporulation protein YtfJ
Thexy_1221	COG1686	Belongs to the peptidase S11 family
Thexy_1223	COG0445	tRNA wobble uridine modification
Thexy_1224	COG1187	pseudouridine synthase activity
Thexy_1226	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Thexy_1227	COG0010	Belongs to the arginase family
Thexy_1229	COG1388	LysM domain
Thexy_1231	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Thexy_1234	COG2081	HI0933 family
Thexy_1236	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Thexy_1238	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Thexy_1239	COG0539	negative regulation of cytoplasmic translation
Thexy_1240	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Thexy_1241	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Thexy_1242	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Thexy_1244	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Thexy_1245	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Thexy_1246	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Thexy_1247	COG1923	regulation of RNA biosynthetic process
Thexy_1248	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Thexy_1249	COG0328	RNA-DNA hybrid ribonuclease activity
Thexy_1250	COG4974	Belongs to the 'phage' integrase family
Thexy_1251	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Thexy_1252	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
Thexy_1253	COG0464	growth
Thexy_1254	COG0017	Asparaginyl-tRNA synthetase
Thexy_1257	COG0613	PHP domain protein
Thexy_1258	COG2359	stage V sporulation protein S
Thexy_1259	COG1692	metallophosphoesterase
Thexy_1260	COG1418	mRNA catabolic process
Thexy_1261	COG0419	ATPase involved in DNA repair
Thexy_1266	COG2137	regulation of response to DNA damage stimulus
Thexy_1267	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Thexy_1269	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Thexy_1270	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Thexy_1271	COG1674	ftsk spoiiie
Thexy_1273	COG0740	serine-type endopeptidase activity
Thexy_1274	COG0527	aspartate kinase activity
Thexy_1277	COG0756	dUTP diphosphatase activity
Thexy_1278	COG0612	Peptidase, M16
Thexy_1279	COG0726	polysaccharide deacetylase
Thexy_1280	COG1185	polyribonucleotide nucleotidyltransferase activity
Thexy_1281	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Thexy_1282	COG0196	riboflavin kinase activity
Thexy_1283	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Thexy_1284	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Thexy_1285	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Thexy_1288	COG2740	Nucleic-acid-binding protein implicated in transcription termination
Thexy_1289	COG0195	Participates in both transcription termination and antitermination
Thexy_1290	COG0779	Required for maturation of 30S ribosomal subunits
Thexy_1291	COG2176	DNA-directed DNA polymerase activity
Thexy_1293	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Thexy_1294	COG0750	zinc metalloprotease
Thexy_1295	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Thexy_1296	COG4589	Belongs to the CDS family
Thexy_1297	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Thexy_1299	COG0233	cytoplasmic translational termination
Thexy_1300	COG0528	UMP kinase activity
Thexy_1301	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Thexy_1302	COG0052	Belongs to the universal ribosomal protein uS2 family
Thexy_1305	COG1191	sigma factor activity
Thexy_1306	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Thexy_1307	COG1776	CheC inhibitor of MCP methylation
Thexy_1309	COG2198	Histidine kinase
Thexy_1309	COG0643	Histidine kinase
Thexy_1311	COG0455	bacterial-type flagellum organization
Thexy_1313	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Thexy_1314	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Thexy_1315	COG1684	flagellar biosynthetic protein fliR
Thexy_1316	COG1987	bacterial-type flagellum assembly
Thexy_1317	COG1338	Plays a role in the flagellum-specific transport system
Thexy_1319	COG2201	protein-glutamate methylesterase activity
Thexy_1320	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Thexy_1320	COG1776	CheC inhibitor of MCP methylation
Thexy_1321	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Thexy_1322	COG1580	Controls the rotational direction of flagella during chemotaxis
Thexy_1325	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Thexy_1329	COG1157	protein secretion by the type III secretion system
Thexy_1331	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Thexy_1332	COG1766	The M ring may be actively involved in energy transduction
Thexy_1333	COG1677	Flagellar hook-basal body complex protein FliE
Thexy_1334	COG1558	bacterial-type flagellum-dependent cell motility
Thexy_1335	COG1815	bacterial-type flagellum-dependent cell motility
Thexy_1337	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Thexy_1338	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Thexy_1339	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Thexy_1340	COG0758	DNA mediated transformation
Thexy_1340	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Thexy_1341	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Thexy_1342	COG0792	nuclease activity
Thexy_1343	COG0180	Tryptophanyl-tRNA synthetase
Thexy_1344	COG0606	chelatase, subunit chli
Thexy_1346	COG0335	large ribosomal subunit rRNA binding
Thexy_1347	COG0336	Belongs to the RNA methyltransferase TrmD family
Thexy_1348	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Thexy_1349	COG1837	Belongs to the UPF0109 family
Thexy_1350	COG0228	four-way junction DNA binding
Thexy_1351	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Thexy_1352	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
Thexy_1353	COG0552	protein localization to endoplasmic reticulum
Thexy_1355	COG2359	stage V sporulation protein S
Thexy_1357	COG0571	ribonuclease III activity
Thexy_1358	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Thexy_1359	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Thexy_1360	COG1028	Short-chain dehydrogenase reductase Sdr
Thexy_1361	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Thexy_1362	COG2070	2-Nitropropane dioxygenase
Thexy_1363	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Thexy_1364	COG0416	fatty acid biosynthetic process
Thexy_1365	COG2030	dehydratase
Thexy_1366	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Thexy_1367	COG1399	metal-binding, possibly nucleic acid-binding protein
Thexy_1368	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Thexy_1369	COG0280	phosphate acetyltransferase
Thexy_1371	COG3314	Sporulation integral membrane protein YlbJ
Thexy_1373	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Thexy_1374	COG0742	ribosomal rna small subunit methyltransferase
Thexy_1376	COG1307	EDD domain protein, DegV family
Thexy_1377	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Thexy_1378	COG1461	Dihydroxyacetone kinase
Thexy_1379	COG1302	Protein conserved in bacteria
Thexy_1384	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Thexy_1385	COG1162	GTPase activity
Thexy_1386	COG2815	serine threonine protein kinase
Thexy_1386	COG0515	serine threonine protein kinase
Thexy_1387	COG0631	protein serine/threonine phosphatase activity
Thexy_1388	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Thexy_1389	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Thexy_1389	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Thexy_1390	COG2738	Putative neutral zinc metallopeptidase
Thexy_1392	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Thexy_1393	COG0242	peptide deformylase activity
Thexy_1394	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Thexy_1395	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Thexy_1397	COG0194	GDP metabolic process
Thexy_1399	COG1561	YicC-like family, N-terminal region
Thexy_1400	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Thexy_1402	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
Thexy_1406	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Thexy_1407	COG0167	dihydroorotate dehydrogenase activity
Thexy_1408	COG0543	2 iron, 2 sulfur cluster binding
Thexy_1410	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Thexy_1411	COG0540	Belongs to the ATCase OTCase family
Thexy_1412	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Thexy_1413	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Thexy_1414	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Thexy_1416	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Thexy_1417	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Thexy_1418	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Thexy_1418	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Thexy_1421	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Thexy_1422	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Thexy_1429	COG0343	queuine tRNA-ribosyltransferase activity
Thexy_1430	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Thexy_1431	COG2247	cell wall binding repeat
Thexy_1431	COG2385	sporulation resulting in formation of a cellular spore
Thexy_1433	COG2255	four-way junction helicase activity
Thexy_1434	COG0632	four-way junction helicase activity
Thexy_1435	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Thexy_1438	COG0217	transcriptional regulatory protein
Thexy_1439	COG0730	response to heat
Thexy_1445	COG1739	Uncharacterized protein family UPF0029
Thexy_1446	COG0494	nUDIX hydrolase
Thexy_1448	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Thexy_1451	COG1959	2 iron, 2 sulfur cluster binding
Thexy_1452	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Thexy_1454	COG3118	belongs to the thioredoxin family
Thexy_1455	COG1937	Protein conserved in bacteria
Thexy_1456	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Thexy_1458	COG0124	histidyl-tRNA synthetase
Thexy_1459	COG0564	pseudouridine synthase activity
Thexy_1460	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Thexy_1462	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Thexy_1466	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Thexy_1470	COG0134	indole-3-glycerol-phosphate synthase activity
Thexy_1471	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Thexy_1472	COG0512	Glutamine amidotransferase of anthranilate synthase
Thexy_1472	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Thexy_1474	COG3464	Transposase
Thexy_1476	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Thexy_1477	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Thexy_1479	COG3599	regulation of cell shape
Thexy_1480	COG2302	S4 RNA-binding domain
Thexy_1482	COG1799	cell septum assembly
Thexy_1483	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Thexy_1488	COG0557	exoribonuclease II activity
Thexy_1492	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Thexy_1492	COG0574	Belongs to the PEP-utilizing enzyme family
Thexy_1493	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Thexy_1494	COG0423	glycine-tRNA ligase activity
Thexy_1498	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Thexy_1499	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Thexy_1500	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Thexy_1501	COG1480	7TM receptor with intracellular HD hydrolase
Thexy_1502	COG1702	phosphate starvation-inducible protein PhoH
Thexy_1505	COG1610	YqeY-like protein
Thexy_1506	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Thexy_1507	COG0537	adenosine 5'-monophosphoramidase activity
Thexy_1508	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Thexy_1509	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Thexy_1510	COG2264	protein methyltransferase activity
Thexy_1511	COG0484	heat shock protein binding
Thexy_1512	COG0443	Heat shock 70 kDa protein
Thexy_1513	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Thexy_1515	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Thexy_1516	COG0481	GTPase activity
Thexy_1518	COG0438	transferase activity, transferring glycosyl groups
Thexy_1520	COG0860	N-Acetylmuramoyl-L-alanine amidase
Thexy_1522	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Thexy_1524	COG0268	Binds directly to 16S ribosomal RNA
Thexy_1526	COG2333	competence protein COMEC
Thexy_1526	COG0658	competence protein
Thexy_1531	COG1131	(ABC) transporter
Thexy_1536	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Thexy_1537	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Thexy_1539	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Thexy_1542	COG0438	transferase activity, transferring glycosyl groups
Thexy_1543	COG0493	'glutamate synthase
Thexy_1547	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Thexy_1548	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Thexy_1549	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Thexy_1551	COG1596	polysaccharide export
Thexy_1551	COG1555	photosystem II stabilization
Thexy_1552	COG1686	Belongs to the peptidase S11 family
Thexy_1553	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
Thexy_1554	COG2964	Protein conserved in bacteria
Thexy_1555	COG0799	negative regulation of ribosome biogenesis
Thexy_1556	COG1713	HD superfamily hydrolase involved in NAD metabolism
Thexy_1557	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Thexy_1558	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Thexy_1560	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Thexy_1562	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Thexy_1563	COG1530	ribonuclease E activity
Thexy_1566	COG1994	Peptidase M50
Thexy_1566	COG0517	IMP dehydrogenase activity
Thexy_1567	COG1388	LysM domain
Thexy_1567	COG0739	heme binding
Thexy_1569	COG0772	Belongs to the SEDS family
Thexy_1570	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Thexy_1571	COG2894	cell division
Thexy_1572	COG0850	regulation of cytokinetic process
Thexy_1576	COG1077	Cell shape determining protein MreB Mrl
Thexy_1577	COG2003	Belongs to the UPF0758 family
Thexy_1578	COG0424	maF-like protein
Thexy_1587	COG2878	Part of a membrane complex involved in electron transport
Thexy_1591	COG0741	lytic transglycosylase activity
Thexy_1593	COG0791	NLP P60 protein
Thexy_1596	COG2707	UPF0756 membrane protein
Thexy_1597	COG0741	lytic transglycosylase activity
Thexy_1598	COG0237	dephospho-CoA kinase activity
Thexy_1601	COG1595	DNA-templated transcription, initiation
Thexy_1602	COG1376	ErfK ybiS ycfS ynhG family protein
Thexy_1604	COG1113	amino acid transport
Thexy_1605	COG1983	PspC domain protein
Thexy_1606	COG3858	chitin binding
Thexy_1606	COG1388	LysM domain
Thexy_1609	COG4475	Protein of unknown function (DUF436)
Thexy_1610	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Thexy_1614	COG0745	RESPONSE REGULATOR receiver
Thexy_1616	COG1013	pyruvate-flavodoxin oxidoreductase activity
Thexy_1617	COG0674	pyruvate-flavodoxin oxidoreductase activity
Thexy_1617	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Thexy_1619	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
Thexy_1621	COG0346	lactoylglutathione lyase activity
Thexy_1626	COG0531	amino acid
Thexy_1628	COG1297	OPT oligopeptide transporter protein
Thexy_1633	COG3426	butyrate kinase activity
Thexy_1635	COG0280	phosphate acetyltransferase
Thexy_1642	COG0739	heme binding
Thexy_1644	COG3858	chitin binding
Thexy_1647	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Thexy_1648	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Thexy_1651	COG1252	NADH dehydrogenase
Thexy_1652	COG0745	RESPONSE REGULATOR receiver
Thexy_1652	COG3706	GGDEF domain
Thexy_1656	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Thexy_1657	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Thexy_1658	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Thexy_1659	COG2171	N-acyltransferase activity
Thexy_1662	COG0726	polysaccharide deacetylase
Thexy_1663	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Thexy_1667	COG2182	Extracellular solute-binding protein
Thexy_1669	COG0395	ABC-type sugar transport system, permease component
Thexy_1670	COG1175	transmembrane transport
Thexy_1676	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Thexy_1680	COG3464	Transposase
Thexy_1682	COG0285	dihydrofolate synthase activity
Thexy_1684	COG0525	valine-tRNA ligase activity
Thexy_1685	COG1268	BioY protein
Thexy_1687	COG1691	(AIR) carboxylase
Thexy_1688	COG1606	tRNA processing
Thexy_1689	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Thexy_1691	COG0671	phosphoesterase, PA-phosphatase related
Thexy_1692	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Thexy_1693	COG0426	domain, Protein
Thexy_1697	COG0105	UTP biosynthetic process
Thexy_1699	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Thexy_1701	COG3949	Membrane
Thexy_1702	COG1316	TRANSCRIPTIONal
Thexy_1706	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Thexy_1707	COG4464	protein tyrosine phosphatase activity
Thexy_1708	COG0489	protein tyrosine kinase activity
Thexy_1709	COG3944	biosynthesis protein
Thexy_1712	COG5464	transposase or invertase
Thexy_1717	COG1942	4-Oxalocrotonate Tautomerase
Thexy_1725	COG0395	ABC-type sugar transport system, permease component
Thexy_1726	COG1175	transmembrane transport
Thexy_1727	COG1653	transport
Thexy_1731	COG0395	ABC-type sugar transport system, permease component
Thexy_1732	COG4209	transmembrane transport
Thexy_1734	COG3275	phosphorelay sensor kinase activity
Thexy_1735	COG2207	Transcriptional regulator
Thexy_1735	COG4753	response regulator
Thexy_1735	COG4753	response regulator
Thexy_1735	COG2207	Transcriptional regulator
Thexy_1736	COG3458	cephalosporin-C deacetylase activity
Thexy_1737	COG3664	PFAM glycoside hydrolase family 39
Thexy_1740	COG0673	inositol 2-dehydrogenase activity
Thexy_1744	COG0395	ABC-type sugar transport system, permease component
Thexy_1745	COG4209	transmembrane transport
Thexy_1747	COG1802	Transcriptional regulator
Thexy_1758	COG1401	restriction endodeoxyribonuclease activity
Thexy_1764	COG1201	RNA secondary structure unwinding
Thexy_1769	COG3464	Transposase
Thexy_1772	COG3465	dGTPase activity
Thexy_1773	COG1078	dGTPase activity
Thexy_1776	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Thexy_1783	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
Thexy_1783	COG0662	Cupin 2, conserved barrel domain protein
Thexy_1796	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Thexy_1801	COG0463	Glycosyl transferase, family 2
Thexy_1801	COG1216	Glycosyl transferase, family 2
Thexy_1812	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
Thexy_1813	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Thexy_1815	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Thexy_1816	COG1116	anion transmembrane transporter activity
Thexy_1817	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Thexy_1818	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Thexy_1818	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Thexy_1821	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Thexy_1822	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Thexy_1823	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Thexy_1824	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Thexy_1825	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Thexy_1826	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Thexy_1827	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Thexy_1828	COG0356	it plays a direct role in the translocation of protons across the membrane
Thexy_1829	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Thexy_1830	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Thexy_1832	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Thexy_1833	COG0740	serine-type endopeptidase activity
Thexy_1834	COG0544	peptidyl-prolyl cis-trans isomerase activity
Thexy_1836	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Thexy_1838	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Thexy_1841	COG3546	catalase activity
Thexy_1842	COG1410	methionine synthase
Thexy_1842	COG0646	methionine synthase
Thexy_1843	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Thexy_1843	COG0646	methionine synthase
Thexy_1848	COG0778	Nitroreductase
Thexy_1849	COG2195	Cleaves the N-terminal amino acid of tripeptides
Thexy_1853	COG1199	ATP-dependent helicase activity
Thexy_1866	COG1516	flagellar protein fliS
Thexy_1867	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Thexy_1874	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Thexy_1875	COG0110	maltose O-acetyltransferase activity
Thexy_1876	COG2089	acid synthase
Thexy_1877	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Thexy_1878	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Thexy_1878	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Thexy_1879	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Thexy_1880	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Thexy_1881	COG1086	Polysaccharide biosynthesis protein
Thexy_1882	COG2604	Protein of unknown function DUF115
Thexy_1887	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Thexy_1888	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Thexy_1889	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
Thexy_1891	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Thexy_1892	COG4786	Flagellar basal body rod
Thexy_1892	COG1256	bacterial-type flagellum assembly
Thexy_1896	COG1040	competence protein
Thexy_1897	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Thexy_1899	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Thexy_1899	COG2199	diguanylate cyclase activity
Thexy_1900	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Thexy_1901	COG1592	Rubrerythrin
Thexy_1902	COG0450	alkyl hydroperoxide reductase
Thexy_1907	COG5002	protein histidine kinase activity
Thexy_1908	COG0745	RESPONSE REGULATOR receiver
Thexy_1909	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Thexy_1910	COG1609	Transcriptional regulator
Thexy_1912	COG0561	phosphatase activity
Thexy_1913	COG2323	membrane
Thexy_1919	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Thexy_1921	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Thexy_1923	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Thexy_1925	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Thexy_1926	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Thexy_1927	COG3711	transcriptional antiterminator
Thexy_1928	COG2190	(PTS) system
Thexy_1929	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Thexy_1929	COG1263	PTS System
Thexy_1931	COG0840	transmembrane signaling receptor activity
Thexy_1933	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Thexy_1935	COG2188	Transcriptional regulator
Thexy_1939	COG1744	ABC transporter substrate-binding protein PnrA-like
Thexy_1950	COG0484	heat shock protein binding
Thexy_1955	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Thexy_1956	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
Thexy_1957	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Thexy_1962	COG1797	cobyrinic acid a,c-diamide synthase activity
Thexy_1963	COG1120	ATPase activity
Thexy_1964	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Thexy_1965	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Thexy_1974	COG0531	amino acid
Thexy_1975	COG0116	Belongs to the methyltransferase superfamily
Thexy_1976	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Thexy_1978	COG1522	sequence-specific DNA binding
Thexy_1979	COG0436	Aminotransferase
Thexy_1983	COG0671	phosphoesterase, PA-phosphatase related
Thexy_1984	COG0735	belongs to the Fur family
Thexy_1985	COG0803	Belongs to the bacterial solute-binding protein 9 family
Thexy_1986	COG1121	(ABC) transporter
Thexy_1987	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Thexy_1991	COG0730	response to heat
Thexy_1992	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Thexy_1993	COG0737	Belongs to the 5'-nucleotidase family
Thexy_1995	COG1447	Phosphotransferase system cellobiose-specific component IIA
Thexy_1997	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Thexy_1999	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Thexy_1999	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Thexy_2000	COG0531	amino acid
Thexy_2002	COG1392	Phosphate transport regulator
Thexy_2003	COG0306	phosphate transporter
Thexy_2006	COG0495	leucyl-tRNA aminoacylation
Thexy_2011	COG2201	protein-glutamate methylesterase activity
Thexy_2012	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Thexy_2014	COG2198	Histidine kinase
Thexy_2014	COG0643	Histidine kinase
Thexy_2015	COG0835	chemotaxis
Thexy_2018	COG0582	viral genome integration into host DNA
Thexy_2019	COG0436	Aminotransferase
Thexy_2021	COG4214	carbohydrate transport
Thexy_2024	COG4213	ABC transporter substrate-binding protein
Thexy_2025	COG2207	Transcriptional regulator
Thexy_2025	COG4753	response regulator
Thexy_2026	COG3275	phosphorelay sensor kinase activity
Thexy_2035	COG1028	Short-chain dehydrogenase reductase Sdr
Thexy_2036	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
Thexy_2037	COG1609	Transcriptional regulator
Thexy_2039	COG0246	Mannitol dehydrogenase
Thexy_2040	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Thexy_2041	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Thexy_2042	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Thexy_2044	COG1349	DNA-binding transcription factor activity
Thexy_2046	COG0534	Mate efflux family protein
Thexy_2048	COG2721	sulfolactate sulfo-lyase activity
Thexy_2049	COG0246	Mannitol dehydrogenase
Thexy_2051	COG0395	ABC-type sugar transport system, permease component
Thexy_2052	COG1175	transmembrane transport
Thexy_2054	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
Thexy_2055	COG1609	Transcriptional regulator
Thexy_2056	COG1904	glucuronate isomerase
Thexy_2057	COG1388	LysM domain
Thexy_2057	COG3858	chitin binding
Thexy_2059	COG0493	'glutamate synthase
Thexy_2062	COG0039	L-malate dehydrogenase activity
Thexy_2066	COG0586	Pfam SNARE associated Golgi protein
Thexy_2067	COG0297	glycogen (starch) synthase activity
Thexy_2076	COG3507	Belongs to the glycosyl hydrolase 43 family
Thexy_2079	COG0395	ABC-type sugar transport system, permease component
Thexy_2080	COG1175	transmembrane transport
Thexy_2083	COG1070	Carbohydrate kinase
Thexy_2084	COG4806	L-rhamnose isomerase
Thexy_2087	COG4656	Part of a membrane complex involved in electron transport
Thexy_2088	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
Thexy_2089	COG4869	propanediol catabolic process
Thexy_2090	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Thexy_2091	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Thexy_2092	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Thexy_2094	COG1063	alcohol dehydrogenase
Thexy_2103	COG1349	DNA-binding transcription factor activity
Thexy_2104	COG5464	transposase or invertase
Thexy_2106	COG3875	lactate racemase activity
Thexy_2107	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Thexy_2110	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Thexy_2114	COG0534	Mate efflux family protein
Thexy_2115	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Thexy_2121	COG1131	(ABC) transporter
Thexy_2123	COG0864	Transcriptional regulator
Thexy_2124	COG0310	cobalt ion transport
Thexy_2125	COG0310	cobalt ion transport
Thexy_2127	COG1122	ATPase activity
Thexy_2128	COG3344	reverse transcriptase
Thexy_2129	COG2814	Major facilitator Superfamily
Thexy_2139	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thexy_2142	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Thexy_2143	COG0800	Aldolase
Thexy_2144	COG1609	Transcriptional regulator
Thexy_2146	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Thexy_2148	COG1070	Carbohydrate kinase
Thexy_2150	COG0446	pyridine nucleotide-disulphide oxidoreductase
Thexy_2150	COG1902	pentaerythritol trinitrate reductase activity
Thexy_2154	COG5434	Belongs to the glycosyl hydrolase 28 family
Thexy_2154	COG4632	Exopolysaccharide biosynthesis protein
Thexy_2157	COG1979	alcohol dehydrogenase
Thexy_2159	COG0463	Glycosyl transferase, family 2
Thexy_2159	COG0457	Tetratricopeptide repeat
Thexy_2160	COG0840	transmembrane signaling receptor activity
Thexy_2165	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Thexy_2172	COG4786	Flagellar basal body rod
Thexy_2174	COG1609	Transcriptional regulator
Thexy_2176	COG2385	sporulation resulting in formation of a cellular spore
Thexy_2184	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Thexy_2185	COG0531	amino acid
Thexy_2187	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Thexy_2189	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Thexy_2190	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Thexy_2192	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Thexy_2193	COG0698	ribose 5-phosphate isomerase
Thexy_2194	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Thexy_2195	COG0009	L-threonylcarbamoyladenylate synthase
Thexy_2198	COG2890	protein-(glutamine-N5) methyltransferase activity
Thexy_2199	COG3872	metal-dependent enzyme
Thexy_2200	COG1435	thymidine kinase activity
Thexy_2201	COG0254	rRNA binding
Thexy_2202	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Thexy_2205	COG0745	RESPONSE REGULATOR receiver
Thexy_2206	COG2247	cell wall binding repeat
Thexy_2206	COG0860	N-Acetylmuramoyl-L-alanine amidase
Thexy_2208	COG1132	(ABC) transporter
Thexy_2209	COG1132	(ABC) transporter
Thexy_2215	COG1175	transmembrane transport
Thexy_2217	COG1609	Transcriptional regulator
Thexy_2225	COG0840	transmembrane signaling receptor activity
Thexy_2228	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thexy_2228	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thexy_2228	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thexy_2229	COG1105	Belongs to the carbohydrate kinase PfkB family
Thexy_2230	COG1349	DNA-binding transcription factor activity
Thexy_2237	COG0463	Glycosyl transferase, family 2
Thexy_2238	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Thexy_2241	COG2205	protein histidine kinase activity
Thexy_2241	COG2770	Histidine kinase
Thexy_2242	COG0745	RESPONSE REGULATOR receiver
Thexy_2243	COG2373	Large extracellular alpha-helical protein
Thexy_2250	COG0504	CTP synthase activity
Thexy_2251	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Thexy_2256	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Thexy_2257	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Thexy_2258	COG1929	Belongs to the glycerate kinase type-1 family
Thexy_2259	COG0793	Belongs to the peptidase S41A family
Thexy_2259	COG3409	Peptidoglycan-binding domain 1 protein
Thexy_2261	COG0083	homoserine kinase activity
Thexy_2262	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Thexy_2263	COG0460	homoserine dehydrogenase
Thexy_2264	COG4492	Belongs to the UPF0735 family
Thexy_2266	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Thexy_2267	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Thexy_2267	COG0674	pyruvate-flavodoxin oxidoreductase activity
Thexy_2268	COG1013	pyruvate-flavodoxin oxidoreductase activity
Thexy_2269	COG1132	(ABC) transporter
Thexy_2271	COG1846	Transcriptional regulator
Thexy_2272	COG0038	chloride channel
Thexy_2273	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Thexy_2274	COG1518	maintenance of DNA repeat elements
Thexy_2285	COG1337	RAMP superfamily
Thexy_2292	COG0822	iron-sulfur transferase activity
Thexy_2293	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Thexy_2294	COG0719	Fe-S assembly protein
Thexy_2295	COG0719	Fe-S assembly protein
Thexy_2306	COG1714	RDD family
Thexy_2316	COG1012	belongs to the aldehyde dehydrogenase family
Thexy_2316	COG1454	alcohol dehydrogenase
Thexy_2318	COG0667	Aldo Keto reductase
Thexy_2322	COG1924	4 iron, 4 sulfur cluster binding
Thexy_2327	COG2199	diguanylate cyclase activity
Thexy_2327	COG2203	Gaf domain
Thexy_2330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Thexy_2331	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Thexy_2335	COG5002	protein histidine kinase activity
Thexy_2336	COG0745	RESPONSE REGULATOR receiver
Thexy_2349	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Thexy_2350	COG1518	maintenance of DNA repeat elements
Thexy_2367	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
Thexy_2375	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Thexy_2376	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Thexy_2381	COG3850	Histidine kinase
Thexy_2381	COG5002	protein histidine kinase activity
Thexy_2384	COG2239	Acts as a magnesium transporter
Thexy_2385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Thexy_2386	COG0305	Participates in initiation and elongation during chromosome replication
Thexy_2387	COG0359	binds to the 23S rRNA
Thexy_2388	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
Thexy_2391	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Thexy_2392	COG0629	single-stranded DNA binding
Thexy_2393	COG0360	Binds together with S18 to 16S ribosomal RNA
Thexy_2394	COG4481	Protein conserved in bacteria
Thexy_2395	COG0668	transmembrane transport
Thexy_2400	COG1597	lipid kinase activity
Thexy_2402	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Thexy_2403	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Thexy_2404	COG1475	DNA binding
Thexy_2405	COG1192	Involved in chromosome partitioning
Thexy_2408	COG0357	Ribosomal RNA small subunit methyltransferase G
Thexy_2409	COG0445	tRNA wobble uridine modification
Thexy_2410	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Thexy_2411	COG1847	R3H domain protein
Thexy_2412	COG0706	membrane insertase activity
Thexy_2413	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Thexy_2414	COG0594	ribonuclease P activity
Thexy_2415	COG0230	Belongs to the bacterial ribosomal protein bL34 family