locus-tag	class	description
Theco_0002	COG2195	Cleaves the N-terminal amino acid of tripeptides
Theco_0003	COG0069	glutamate synthase activity
Theco_0004	COG2094	Belongs to the DNA glycosylase MPG family
Theco_0005	COG1063	alcohol dehydrogenase
Theco_0006	COG0659	secondary active sulfate transmembrane transporter activity
Theco_0010	COG2207	Transcriptional regulator
Theco_0010	COG3708	Transcriptional regulator
Theco_0011	COG3693	PFAM glycoside hydrolase, family 10
Theco_0014	COG0477	Major facilitator Superfamily
Theco_0015	COG1846	Transcriptional regulator
Theco_0017	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Theco_0018	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
Theco_0019	COG3507	Belongs to the glycosyl hydrolase 43 family
Theco_0022	COG2972	Histidine kinase
Theco_0023	COG2207	Transcriptional regulator
Theco_0023	COG4753	response regulator
Theco_0024	COG1653	transport
Theco_0026	COG4989	oxidoreductase activity
Theco_0030	COG0500	methyltransferase
Theco_0031	COG1028	Short-chain dehydrogenase reductase Sdr
Theco_0032	COG2746	aminoglycoside 3-N-acetyltransferase activity
Theco_0033	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Theco_0034	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Theco_0035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Theco_0036	COG1131	(ABC) transporter
Theco_0041	COG4166	transmembrane transport
Theco_0042	COG0601	transmembrane transport
Theco_0043	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Theco_0044	COG0444	Belongs to the ABC transporter superfamily
Theco_0045	COG4608	Belongs to the ABC transporter superfamily
Theco_0046	COG1388	LysM domain
Theco_0046	COG3942	CHAP domain
Theco_0047	COG1442	glycosyl transferase family 8
Theco_0050	COG0579	oxidoreductase
Theco_0051	COG0861	Integral membrane protein TerC family
Theco_0053	COG1335	isochorismatase
Theco_0055	COG0346	lactoylglutathione lyase activity
Theco_0057	COG4753	response regulator
Theco_0057	COG2207	Transcriptional regulator
Theco_0058	COG2972	Histidine kinase
Theco_0059	COG1879	ABC-type sugar transport system periplasmic component
Theco_0061	COG1172	Belongs to the binding-protein-dependent transport system permease family
Theco_0062	COG1172	Belongs to the binding-protein-dependent transport system permease family
Theco_0063	COG1879	ABC-type sugar transport system periplasmic component
Theco_0064	COG2801	Transposase and inactivated derivatives
Theco_0072	COG4974	Belongs to the 'phage' integrase family
Theco_0073	COG4974	Belongs to the 'phage' integrase family
Theco_0080	COG2217	Heavy metal translocating P-type atpase
Theco_0090	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Theco_0092	COG1309	transcriptional regulator
Theco_0097	COG1285	pathogenesis
Theco_0099	COG1178	ABC-type Fe3 transport system permease component
Theco_0101	COG1840	ABC-type Fe3 transport system, periplasmic component
Theco_0106	COG3620	sequence-specific DNA binding
Theco_0108	COG0242	peptide deformylase activity
Theco_0111	COG1673	EVE domain
Theco_0113	COG2378	regulation of single-species biofilm formation
Theco_0116	COG1902	pentaerythritol trinitrate reductase activity
Theco_0118	COG0733	neurotransmitter:sodium symporter activity
Theco_0121	COG2814	Major facilitator Superfamily
Theco_0122	COG0640	Transcriptional regulator
Theco_0125	COG3344	reverse transcriptase
Theco_0128	COG2337	Toxic component of a toxin-antitoxin (TA) module
Theco_0129	COG2336	PFAM SpoVT AbrB
Theco_0130	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Theco_0132	COG0656	L-ascorbic acid biosynthetic process
Theco_0134	COG3344	reverse transcriptase
Theco_0136	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Theco_0138	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Theco_0141	COG5002	protein histidine kinase activity
Theco_0142	COG0745	RESPONSE REGULATOR receiver
Theco_0143	COG0739	heme binding
Theco_0149	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
Theco_0150	COG1040	competence protein
Theco_0153	COG3418	PFAM FlgN family protein
Theco_0154	COG1256	bacterial-type flagellum assembly
Theco_0154	COG4786	Flagellar basal body rod
Theco_0155	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Theco_0158	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Theco_0159	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Theco_0161	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Theco_0165	COG1086	Polysaccharide biosynthesis protein
Theco_0166	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
Theco_0169	COG2089	acid synthase
Theco_0171	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Theco_0172	COG1278	Cold shock
Theco_0174	COG0653	protein targeting
Theco_0179	COG1131	(ABC) transporter
Theco_0180	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Theco_0181	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Theco_0182	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Theco_0184	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Theco_0185	COG0137	argininosuccinate synthase activity
Theco_0186	COG0165	Argininosuccinate lyase
Theco_0188	COG2884	Cell division ATP-binding protein ftsE
Theco_0189	COG2177	Part of the ABC transporter FtsEX involved in
Theco_0190	COG0739	heme binding
Theco_0191	COG3409	Peptidoglycan-binding domain 1 protein
Theco_0191	COG0793	Belongs to the peptidase S41A family
Theco_0192	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Theco_0195	COG0556	nucleotide-excision repair
Theco_0203	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Theco_0206	COG0653	protein targeting
Theco_0210	COG0826	peptidase U32
Theco_0212	COG2208	phosphoserine phosphatase activity
Theco_0212	COG2770	Histidine kinase
Theco_0214	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
Theco_0215	COG0210	DNA helicase
Theco_0216	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Theco_0224	COG3880	PFAM UvrB UvrC protein
Theco_0225	COG3869	Catalyzes the specific phosphorylation of arginine residues in
Theco_0226	COG0542	response to heat
Theco_0232	COG1132	(ABC) transporter
Theco_0234	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Theco_0235	COG1216	Glycosyl transferase, family 2
Theco_0235	COG0463	Glycosyl transferase, family 2
Theco_0236	COG4260	virion core protein, lumpy skin disease virus
Theco_0237	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
Theco_0238	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Theco_0239	COG1842	Phage shock protein A
Theco_0240	COG1073	alpha beta
Theco_0241	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Theco_0242	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
Theco_0243	COG1183	phosphatidylcholine synthase activity
Theco_0245	COG4956	integral membrane protein (PIN domain superfamily)
Theco_0247	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Theco_0247	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Theco_0248	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Theco_0249	COG1045	serine acetyltransferase
Theco_0250	COG0215	cysteine-tRNA ligase activity
Theco_0251	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
Theco_0252	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Theco_0253	COG3688	RNA-binding protein containing a PIN domain
Theco_0254	COG1131	(ABC) transporter
Theco_0256	COG1309	transcriptional regulator
Theco_0261	COG2801	Transposase and inactivated derivatives
Theco_0262	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Theco_0264	COG0250	Participates in transcription elongation, termination and antitermination
Theco_0265	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Theco_0266	COG0081	regulation of translation
Theco_0268	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Theco_0269	COG0222	ribosome binding
Theco_0270	COG2813	Specifically methylates the guanine in position
Theco_0271	COG0085	RNA polymerase activity
Theco_0272	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Theco_0273	COG1358	cellular component organization or biogenesis
Theco_0274	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Theco_0275	COG0049	tRNA binding
Theco_0276	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Theco_0277	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Theco_0278	COG1120	ATPase activity
Theco_0280	COG0051	transcription antitermination factor activity, RNA binding
Theco_0281	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Theco_0282	COG0088	Forms part of the polypeptide exit tunnel
Theco_0283	COG0089	rRNA binding
Theco_0284	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Theco_0285	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Theco_0286	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Theco_0287	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Theco_0288	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Theco_0289	COG0255	Belongs to the universal ribosomal protein uL29 family
Theco_0291	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Theco_0292	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Theco_0293	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Theco_0294	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Theco_0295	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Theco_0296	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Theco_0297	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Theco_0298	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Theco_0299	COG1841	ribosomal large subunit assembly
Theco_0300	COG0200	Binds to the 23S rRNA
Theco_0301	COG0201	protein transport
Theco_0302	COG0563	adenylate kinase activity
Theco_0303	COG0024	Methionine aminopeptidase
Theco_0305	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Theco_0306	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Theco_0307	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Theco_0308	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Theco_0309	COG0202	RNA polymerase activity
Theco_0310	COG0203	ribosomal protein L17
Theco_0311	COG0101	tRNA pseudouridine synthase activity
Theco_0312	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Theco_0313	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Theco_0314	COG0175	sulfate reduction
Theco_0315	COG2046	Belongs to the sulfate adenylyltransferase family
Theco_0316	COG0860	N-Acetylmuramoyl-L-alanine amidase
Theco_0317	COG0489	protein tyrosine kinase activity
Theco_0320	COG0726	polysaccharide deacetylase
Theco_0339	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Theco_0340	COG1595	DNA-templated transcription, initiation
Theco_0341	COG5662	AntiSigma factor
Theco_0342	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
Theco_0343	COG4856	YbbR-like protein
Theco_0344	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Theco_0345	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Theco_0348	COG4372	Transposase
Theco_0349	COG3547	Transposase (IS116 IS110 IS902 family)
Theco_0353	COG0346	lactoylglutathione lyase activity
Theco_0354	COG2197	response regulator
Theco_0355	COG4585	Histidine kinase
Theco_0356	COG2311	Membrane
Theco_0362	COG0583	DNA-binding transcription factor activity
Theco_0363	COG0456	acetyltransferase
Theco_0366	COG1252	NADH dehydrogenase
Theco_0374	COG2972	Histidine kinase
Theco_0375	COG4753	response regulator
Theco_0375	COG2207	Transcriptional regulator
Theco_0380	COG3655	Transcriptional regulator
Theco_0381	COG3739	integral membrane protein
Theco_0386	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Theco_0388	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Theco_0389	COG0583	DNA-binding transcription factor activity
Theco_0399	COG0431	NADPH-dependent FMN reductase
Theco_0400	COG0640	Transcriptional regulator
Theco_0401	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
Theco_0402	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Theco_0404	COG3275	phosphorelay sensor kinase activity
Theco_0405	COG2204	response regulator
Theco_0407	COG4209	transmembrane transport
Theco_0408	COG0395	ABC-type sugar transport system, permease component
Theco_0410	COG0583	DNA-binding transcription factor activity
Theco_0411	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Theco_0412	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Theco_0415	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
Theco_0419	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Theco_0420	COG4172	Belongs to the ABC transporter superfamily
Theco_0425	COG1486	melibiose metabolic process
Theco_0427	COG0129	dihydroxy-acid dehydratase activity
Theco_0430	COG1414	Transcriptional regulator
Theco_0435	COG2972	Histidine kinase
Theco_0436	COG4753	response regulator
Theco_0436	COG2207	Transcriptional regulator
Theco_0439	COG0601	transmembrane transport
Theco_0441	COG0444	Belongs to the ABC transporter superfamily
Theco_0442	COG4608	Belongs to the ABC transporter superfamily
Theco_0447	COG0745	RESPONSE REGULATOR receiver
Theco_0448	COG5002	protein histidine kinase activity
Theco_0456	COG2972	Histidine kinase
Theco_0457	COG4753	response regulator
Theco_0457	COG2207	Transcriptional regulator
Theco_0459	COG1175	transmembrane transport
Theco_0461	COG1874	Beta-galactosidase
Theco_0465	COG0662	Cupin 2, conserved barrel domain protein
Theco_0467	COG1489	DNA binding
Theco_0468	COG0842	Transport permease protein
Theco_0470	COG1131	(ABC) transporter
Theco_0471	COG4585	Histidine kinase
Theco_0472	COG2197	response regulator
Theco_0475	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Theco_0483	COG0656	L-ascorbic acid biosynthetic process
Theco_0485	COG2972	Histidine kinase
Theco_0486	COG2207	Transcriptional regulator
Theco_0487	COG1653	transport
Theco_0491	COG3344	reverse transcriptase
Theco_0494	COG0791	NLP P60 protein
Theco_0497	COG1486	melibiose metabolic process
Theco_0501	COG4124	Belongs to the glycosyl hydrolase 26 family
Theco_0504	COG0740	serine-type endopeptidase activity
Theco_0508	COG1028	Short-chain dehydrogenase reductase Sdr
Theco_0510	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Theco_0510	COG3153	acetyltransferase
Theco_0512	COG0673	inositol 2-dehydrogenase activity
Theco_0515	COG0800	Aldolase
Theco_0516	COG1028	Short-chain dehydrogenase reductase Sdr
Theco_0518	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
Theco_0520	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Theco_0524	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
Theco_0529	COG0395	ABC-type sugar transport system, permease component
Theco_0530	COG1175	transmembrane transport
Theco_0531	COG1653	transport
Theco_0533	COG4129	membrane
Theco_0536	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Theco_0539	COG1175	transmembrane transport
Theco_0540	COG0395	ABC-type sugar transport system, permease component
Theco_0541	COG1653	transport
Theco_0542	COG1312	Catalyzes the dehydration of D-mannonate
Theco_0548	COG3336	cytochrome c oxidase
Theco_0550	COG2186	Transcriptional regulator
Theco_0552	COG4152	abc transporter atp-binding protein
Theco_0553	COG1668	transmembrane transport
Theco_0556	COG1609	Transcriptional regulator
Theco_0558	COG3458	cephalosporin-C deacetylase activity
Theco_0559	COG2223	nitrite transmembrane transporter activity
Theco_0560	COG0488	(ABC) transporter
Theco_0562	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Theco_0563	COG0315	cyclic pyranopterin monophosphate synthase activity
Theco_0564	COG0521	Mo-molybdopterin cofactor biosynthetic process
Theco_0566	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Theco_0567	COG0805	protein transport
Theco_0569	COG0459	protein refolding
Theco_0570	COG0736	holo-[acyl-carrier-protein] synthase activity
Theco_0573	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Theco_0574	COG3314	Sporulation integral membrane protein YlbJ
Theco_0575	COG2346	COG2346, Truncated hemoglobins
Theco_0584	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Theco_0585	COG1494	fructose-1,6-bisphosphatase
Theco_0586	COG0105	UTP biosynthetic process
Theco_0590	COG1653	transport
Theco_0591	COG1175	transmembrane transport
Theco_0592	COG0395	ABC-type sugar transport system, permease component
Theco_0609	COG1090	epimerase
Theco_0611	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Theco_0612	COG0788	formyltetrahydrofolate deformylase activity
Theco_0616	COG1739	Uncharacterized protein family UPF0029
Theco_0618	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Theco_0620	COG0561	phosphatase activity
Theco_0621	COG3409	Peptidoglycan-binding domain 1 protein
Theco_0621	COG0793	Belongs to the peptidase S41A family
Theco_0623	COG0024	Methionine aminopeptidase
Theco_0625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Theco_0626	COG4565	transcriptional regulatory protein
Theco_0627	COG3275	phosphorelay sensor kinase activity
Theco_0628	COG1653	transport
Theco_0631	COG0246	Mannitol dehydrogenase
Theco_0632	COG2721	sulfolactate sulfo-lyase activity
Theco_0636	COG0668	transmembrane transport
Theco_0637	COG3275	phosphorelay sensor kinase activity
Theco_0638	COG2207	Transcriptional regulator
Theco_0639	COG4209	transmembrane transport
Theco_0640	COG0395	ABC-type sugar transport system, permease component
Theco_0645	COG1842	Phage shock protein A
Theco_0647	COG1842	Phage shock protein A
Theco_0648	COG4585	Histidine kinase
Theco_0649	COG2197	response regulator
Theco_0650	COG1763	Mo-molybdopterin cofactor biosynthetic process
Theco_0654	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Theco_0657	COG2972	Histidine kinase
Theco_0658	COG2204	response regulator
Theco_0660	COG0395	ABC-type sugar transport system, permease component
Theco_0664	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Theco_0665	COG2706	6-phosphogluconolactonase activity
Theco_0666	COG1073	alpha beta
Theco_0667	COG1470	cell adhesion involved in biofilm formation
Theco_0668	COG1392	Phosphate transport regulator
Theco_0669	COG0306	phosphate transporter
Theco_0671	COG4496	protein, YerC YecD
Theco_0673	COG1597	lipid kinase activity
Theco_0674	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Theco_0675	COG0745	RESPONSE REGULATOR receiver
Theco_0676	COG5002	protein histidine kinase activity
Theco_0676	COG3850	Histidine kinase
Theco_0681	COG2801	Transposase and inactivated derivatives
Theco_0682	COG4948	Mandelate Racemase Muconate Lactonizing
Theco_0692	COG2153	protein acetylation
Theco_0696	COG1686	Belongs to the peptidase S11 family
Theco_0698	COG1695	Transcriptional regulator
Theco_0700	COG1309	transcriptional regulator
Theco_0716	COG2201	protein-glutamate methylesterase activity
Theco_0717	COG0784	Response regulator, receiver
Theco_0717	COG3437	response regulator, receiver
Theco_0718	COG0840	transmembrane signaling receptor activity
Theco_0726	COG2318	DinB family
Theco_0727	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Theco_0728	COG4149	molybdate abc transporter
Theco_0730	COG0746	molybdenum cofactor guanylyltransferase activity
Theco_0732	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Theco_0761	COG1380	Effector of murein hydrolase LrgA
Theco_0762	COG1346	cytolysis
Theco_0763	COG1902	pentaerythritol trinitrate reductase activity
Theco_0765	COG1309	transcriptional regulator
Theco_0768	COG1309	transcriptional regulator
Theco_0774	COG1653	transport
Theco_0777	COG0395	ABC-type sugar transport system, permease component
Theco_0785	COG1136	(ABC) transporter
Theco_0786	COG0577	efflux transmembrane transporter activity
Theco_0786	COG1136	(ABC) transporter
Theco_0788	COG1752	Esterase of the alpha-beta hydrolase superfamily
Theco_0796	COG1309	transcriptional regulator
Theco_0798	COG2011	ABC-type metal ion transport system permease component
Theco_0799	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Theco_0800	COG0667	Aldo Keto reductase
Theco_0803	COG0745	RESPONSE REGULATOR receiver
Theco_0804	COG5002	protein histidine kinase activity
Theco_0808	COG3727	T/G mismatch-specific endonuclease activity
Theco_0810	COG0494	nUDIX hydrolase
Theco_0812	COG1121	(ABC) transporter
Theco_0817	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Theco_0817	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Theco_0819	COG0326	Molecular chaperone. Has ATPase activity
Theco_0822	COG0860	N-Acetylmuramoyl-L-alanine amidase
Theco_0825	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
Theco_0828	COG0739	heme binding
Theco_0829	COG0667	Aldo Keto reductase
Theco_0830	COG3584	3D domain protein
Theco_0830	COG1388	LysM domain
Theco_0831	COG0726	polysaccharide deacetylase
Theco_0836	COG0180	Tryptophanyl-tRNA synthetase
Theco_0841	COG3773	Cell wall hydrolase
Theco_0843	COG1999	signal sequence binding
Theco_0854	COG2972	Histidine kinase
Theco_0855	COG2207	Transcriptional regulator
Theco_0855	COG4753	response regulator
Theco_0856	COG4213	ABC transporter substrate-binding protein
Theco_0858	COG4214	carbohydrate transport
Theco_0859	COG0561	phosphatase activity
Theco_0860	COG2839	Protein conserved in bacteria
Theco_0862	COG2244	polysaccharide biosynthetic process
Theco_0866	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Theco_0867	COG1612	heme a metabolic process
Theco_0869	COG1028	Short-chain dehydrogenase reductase Sdr
Theco_0870	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Theco_0871	COG4844	belongs to the
Theco_0872	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Theco_0873	COG0316	Belongs to the HesB IscA family
Theco_0876	COG0840	transmembrane signaling receptor activity
Theco_0878	COG3275	phosphorelay sensor kinase activity
Theco_0880	COG4213	ABC transporter substrate-binding protein
Theco_0883	COG4214	carbohydrate transport
Theco_0893	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
Theco_0894	COG4988	ABC transporter
Theco_0895	COG1294	oxidase, subunit
Theco_0896	COG1271	oxidase subunit
Theco_0898	COG0745	RESPONSE REGULATOR receiver
Theco_0899	COG5002	protein histidine kinase activity
Theco_0899	COG3850	Histidine kinase
Theco_0900	COG1136	(ABC) transporter
Theco_0907	COG0456	acetyltransferase
Theco_0914	COG0456	acetyltransferase
Theco_0914	COG1214	PFAM Peptidase M22, glycoprotease
Theco_0916	COG1349	DNA-binding transcription factor activity
Theco_0920	COG0477	Major facilitator Superfamily
Theco_0921	COG1609	Transcriptional regulator
Theco_0922	COG4209	transmembrane transport
Theco_0923	COG0395	ABC-type sugar transport system, permease component
Theco_0925	COG3250	beta-galactosidase activity
Theco_0930	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
Theco_0930	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Theco_0933	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Theco_0936	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Theco_0940	COG3459	Glycosyltransferase 36 associated
Theco_0943	COG1902	pentaerythritol trinitrate reductase activity
Theco_0944	COG1272	protein, Hemolysin III
Theco_0945	COG1028	Short-chain dehydrogenase reductase Sdr
Theco_0946	COG3620	sequence-specific DNA binding
Theco_0952	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Theco_0954	COG1191	sigma factor activity
Theco_0955	COG2207	Transcriptional regulator
Theco_0955	COG4753	response regulator
Theco_0956	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Theco_0957	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Theco_0958	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
Theco_0962	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Theco_0964	COG3706	GGDEF domain
Theco_0965	COG3706	GGDEF domain
Theco_0965	COG0745	RESPONSE REGULATOR receiver
Theco_0970	COG0586	Pfam SNARE associated Golgi protein
Theco_0972	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Theco_0976	COG2183	response to ionizing radiation
Theco_0977	COG0778	Nitroreductase
Theco_0980	COG3091	SprT-like family
Theco_0989	COG1069	ribulokinase activity
Theco_0993	COG1609	Transcriptional regulator
Theco_0994	COG2972	Histidine kinase
Theco_0995	COG2207	Transcriptional regulator
Theco_0995	COG4753	response regulator
Theco_0997	COG1175	transmembrane transport
Theco_1001	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Theco_1001	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Theco_1002	COG1482	cell wall glycoprotein biosynthetic process
Theco_1003	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
Theco_1004	COG1242	4 iron, 4 sulfur cluster binding
Theco_1006	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Theco_1007	COG0671	phosphoesterase, PA-phosphatase related
Theco_1008	COG1215	transferase activity, transferring glycosyl groups
Theco_1013	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Theco_1015	COG0028	Belongs to the TPP enzyme family
Theco_1016	COG0440	acetolactate synthase activity
Theco_1017	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Theco_1018	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Theco_1019	COG0473	3-isopropylmalate dehydrogenase activity
Theco_1022	COG1191	sigma factor activity
Theco_1024	COG4191	Histidine kinase
Theco_1025	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Theco_1027	COG1132	(ABC) transporter
Theco_1032	COG1733	regulation of RNA biosynthetic process
Theco_1034	COG1472	Belongs to the glycosyl hydrolase 3 family
Theco_1037	COG0386	Belongs to the glutathione peroxidase family
Theco_1038	COG0322	excinuclease ABC activity
Theco_1043	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Theco_1046	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Theco_1047	COG5001	Diguanylate cyclase
Theco_1047	COG3300	MHYT domain
Theco_1049	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Theco_1050	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
Theco_1052	COG0789	Transcriptional regulator
Theco_1055	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Theco_1058	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Theco_1059	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Theco_1060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Theco_1069	COG1175	transmembrane transport
Theco_1071	COG3507	Belongs to the glycosyl hydrolase 43 family
Theco_1072	COG3250	beta-galactosidase activity
Theco_1076	COG1131	(ABC) transporter
Theco_1081	COG1132	(ABC) transporter
Theco_1082	COG1132	(ABC) transporter
Theco_1085	COG0745	RESPONSE REGULATOR receiver
Theco_1087	COG1312	Catalyzes the dehydration of D-mannonate
Theco_1088	COG1028	Short-chain dehydrogenase reductase Sdr
Theco_1093	COG5566	PFAM Mor transcription activator
Theco_1095	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Theco_1098	COG3850	Histidine kinase
Theco_1099	COG2197	response regulator
Theco_1102	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Theco_1103	COG0072	phenylalanine-tRNA ligase activity
Theco_1103	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Theco_1104	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
Theco_1107	COG1193	negative regulation of DNA recombination
Theco_1108	COG3766	membrane
Theco_1110	COG0477	Major facilitator Superfamily
Theco_1111	COG5337	Spore coat protein CotH
Theco_1115	COG1522	sequence-specific DNA binding
Theco_1116	COG0436	Aminotransferase
Theco_1118	COG2096	Adenosyltransferase
Theco_1120	COG1393	Belongs to the ArsC family
Theco_1125	COG0300	oxidoreductase activity
Theco_1128	COG1131	(ABC) transporter
Theco_1129	COG4473	ABC transporter
Theco_1130	COG2309	aminopeptidase activity
Theco_1132	COG2207	Transcriptional regulator
Theco_1135	COG0688	phosphatidylethanolamine metabolic process
Theco_1136	COG0438	transferase activity, transferring glycosyl groups
Theco_1137	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Theco_1138	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Theco_1139	COG0352	thiamine-phosphate diphosphorylase activity
Theco_1140	COG2022	thiamine diphosphate biosynthetic process
Theco_1141	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Theco_1142	COG0351	phosphomethylpyrimidine kinase
Theco_1148	COG1216	Glycosyl transferase, family 2
Theco_1149	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
Theco_1151	COG1215	transferase activity, transferring glycosyl groups
Theco_1156	COG4641	Protein conserved in bacteria
Theco_1158	COG0438	transferase activity, transferring glycosyl groups
Theco_1160	COG1086	Polysaccharide biosynthesis protein
Theco_1163	COG1216	Glycosyl transferase, family 2
Theco_1163	COG0463	Glycosyl transferase, family 2
Theco_1164	COG1216	Glycosyl transferase, family 2
Theco_1166	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Theco_1174	COG0450	alkyl hydroperoxide reductase
Theco_1175	COG3634	alkyl hydroperoxide reductase activity
Theco_1177	COG0395	ABC-type sugar transport system, permease component
Theco_1178	COG1175	transmembrane transport
Theco_1181	COG1349	DNA-binding transcription factor activity
Theco_1184	COG2972	Histidine kinase
Theco_1186	COG4209	transmembrane transport
Theco_1187	COG0395	ABC-type sugar transport system, permease component
Theco_1192	COG0494	nUDIX hydrolase
Theco_1193	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Theco_1195	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Theco_1196	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Theco_1212	COG3189	MarR family transcriptional regulator
Theco_1214	COG1794	racemase activity, acting on amino acids and derivatives
Theco_1215	COG3401	FG-GAP repeat protein
Theco_1216	COG4209	transmembrane transport
Theco_1217	COG0395	ABC-type sugar transport system, permease component
Theco_1218	COG1653	transport
Theco_1219	COG2207	Transcriptional regulator
Theco_1221	COG2755	lipolytic protein G-D-S-L family
Theco_1223	COG1960	acyl-CoA dehydrogenase activity
Theco_1224	COG0673	inositol 2-dehydrogenase activity
Theco_1227	COG0673	inositol 2-dehydrogenase activity
Theco_1229	COG4209	transmembrane transport
Theco_1230	COG0395	ABC-type sugar transport system, permease component
Theco_1232	COG2972	Histidine kinase
Theco_1233	COG2207	Transcriptional regulator
Theco_1233	COG4753	response regulator
Theco_1236	COG1760	l-serine dehydratase
Theco_1237	COG1760	l-serine dehydratase
Theco_1238	COG1473	amidohydrolase
Theco_1239	COG0445	tRNA wobble uridine modification
Theco_1240	COG0604	alcohol dehydrogenase
Theco_1241	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Theco_1242	COG0363	glucosamine-6-phosphate deaminase activity
Theco_1245	COG4209	transmembrane transport
Theco_1246	COG0395	ABC-type sugar transport system, permease component
Theco_1247	COG2169	Transcriptional regulator
Theco_1248	COG1940	carbohydrate kinase activity
Theco_1251	COG1904	glucuronate isomerase
Theco_1253	COG0673	inositol 2-dehydrogenase activity
Theco_1254	COG2972	Histidine kinase
Theco_1255	COG4753	response regulator
Theco_1255	COG2207	Transcriptional regulator
Theco_1256	COG1653	transport
Theco_1257	COG1175	transmembrane transport
Theco_1258	COG0395	ABC-type sugar transport system, permease component
Theco_1259	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
Theco_1261	COG3347	Dehydrogenase
Theco_1261	COG1028	Short-chain dehydrogenase reductase Sdr
Theco_1263	COG4806	L-rhamnose isomerase
Theco_1264	COG1070	Carbohydrate kinase
Theco_1265	COG1349	DNA-binding transcription factor activity
Theco_1267	COG1139	Iron-sulfur cluster binding protein
Theco_1270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Theco_1270	COG0723	plastoquinol--plastocyanin reductase activity
Theco_1272	COG1879	ABC-type sugar transport system periplasmic component
Theco_1274	COG1129	ABC transporter
Theco_1275	COG1172	Belongs to the binding-protein-dependent transport system permease family
Theco_1278	COG3959	Transketolase, thiamine diphosphate binding domain
Theco_1279	COG3958	Transketolase
Theco_1280	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Theco_1281	COG2972	Histidine kinase
Theco_1282	COG2207	Transcriptional regulator
Theco_1282	COG4753	response regulator
Theco_1285	COG0395	ABC-type sugar transport system, permease component
Theco_1287	COG2197	response regulator
Theco_1290	COG1028	Short-chain dehydrogenase reductase Sdr
Theco_1295	COG0385	Bile acid
Theco_1296	COG5002	protein histidine kinase activity
Theco_1297	COG0745	RESPONSE REGULATOR receiver
Theco_1300	COG2268	Band 7 protein
Theco_1304	COG2205	protein histidine kinase activity
Theco_1305	COG1940	carbohydrate kinase activity
Theco_1309	COG2151	metal-sulfur cluster biosynthetic enzyme
Theco_1313	COG2115	Belongs to the xylose isomerase family
Theco_1314	COG1070	Carbohydrate kinase
Theco_1316	COG0546	phosphoglycolate phosphatase activity
Theco_1324	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Theco_1325	COG0573	inorganic phosphate transmembrane transporter activity
Theco_1326	COG0581	inorganic phosphate transmembrane transporter activity
Theco_1328	COG0704	Plays a role in the regulation of phosphate uptake
Theco_1332	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Theco_1333	COG1971	Probably functions as a manganese efflux pump
Theco_1334	COG0237	dephospho-CoA kinase activity
Theco_1335	COG0741	lytic transglycosylase activity
Theco_1337	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Theco_1346	COG2182	Extracellular solute-binding protein
Theco_1347	COG1175	transmembrane transport
Theco_1350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Theco_1359	COG1609	Transcriptional regulator
Theco_1360	COG2972	Histidine kinase
Theco_1361	COG4209	transmembrane transport
Theco_1362	COG0395	ABC-type sugar transport system, permease component
Theco_1366	COG4753	response regulator
Theco_1366	COG2207	Transcriptional regulator
Theco_1367	COG2972	Histidine kinase
Theco_1368	COG2207	Transcriptional regulator
Theco_1368	COG4753	response regulator
Theco_1370	COG4209	transmembrane transport
Theco_1371	COG0395	ABC-type sugar transport system, permease component
Theco_1372	COG0475	glutathione-regulated potassium exporter activity
Theco_1373	COG0490	domain, Protein
Theco_1374	COG3344	reverse transcriptase
Theco_1376	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Theco_1379	COG1705	Flagellar rod assembly protein muramidase FlgJ
Theco_1386	COG2445	Protein of unknown function DUF86
Theco_1390	COG4753	response regulator
Theco_1390	COG2207	Transcriptional regulator
Theco_1393	COG4844	belongs to the
Theco_1394	COG1368	sulfuric ester hydrolase activity
Theco_1396	COG2814	Major facilitator Superfamily
Theco_1397	COG0805	protein transport
Theco_1398	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Theco_1401	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Theco_1401	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Theco_1402	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Theco_1403	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Theco_1405	COG2843	Capsule synthesis protein
Theco_1407	COG3437	response regulator, receiver
Theco_1407	COG0784	Response regulator, receiver
Theco_1409	COG1136	(ABC) transporter
Theco_1412	COG1136	(ABC) transporter
Theco_1412	COG0577	efflux transmembrane transporter activity
Theco_1413	COG1164	Oligoendopeptidase f
Theco_1418	COG0217	transcriptional regulatory protein
Theco_1419	COG0778	Nitroreductase
Theco_1425	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Theco_1426	COG0513	Belongs to the DEAD box helicase family
Theco_1427	COG5578	integral membrane protein
Theco_1429	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Theco_1430	COG0705	Rhomboid family
Theco_1431	COG0583	DNA-binding transcription factor activity
Theco_1432	COG2738	Putative neutral zinc metallopeptidase
Theco_1433	COG0789	Transcriptional regulator
Theco_1434	COG0004	ammonium transporteR
Theco_1436	COG2176	DNA-directed DNA polymerase activity
Theco_1438	COG2814	Major facilitator Superfamily
Theco_1440	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Theco_1442	COG1141	Ferredoxin
Theco_1445	COG1376	ErfK ybiS ycfS ynhG family protein
Theco_1447	COG0167	dihydroorotate dehydrogenase activity
Theco_1448	COG2357	RelA SpoT domain protein
Theco_1449	COG1547	Domain of unknown function (DUF309)
Theco_1451	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Theco_1452	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
Theco_1452	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Theco_1453	COG1187	pseudouridine synthase activity
Theco_1454	COG0561	phosphatase activity
Theco_1457	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Theco_1457	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
Theco_1462	COG3706	GGDEF domain
Theco_1464	COG0420	3'-5' exonuclease activity
Theco_1465	COG4717	serine-type aminopeptidase activity
Theco_1468	COG3949	Membrane
Theco_1470	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Theco_1474	COG0860	N-Acetylmuramoyl-L-alanine amidase
Theco_1478	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Theco_1480	COG2514	catechol 2,3-dioxygenase activity
Theco_1484	COG2197	response regulator
Theco_1486	COG1131	(ABC) transporter
Theco_1489	COG3344	reverse transcriptase
Theco_1497	COG1063	alcohol dehydrogenase
Theco_1502	COG0673	inositol 2-dehydrogenase activity
Theco_1503	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Theco_1506	COG1486	melibiose metabolic process
Theco_1507	COG4977	sequence-specific DNA binding
Theco_1508	COG1501	Belongs to the glycosyl hydrolase 31 family
Theco_1510	COG2801	Transposase and inactivated derivatives
Theco_1517	COG4372	Transposase
Theco_1519	COG2972	Histidine kinase
Theco_1520	COG2207	Transcriptional regulator
Theco_1520	COG4753	response regulator
Theco_1522	COG1175	transmembrane transport
Theco_1523	COG0395	ABC-type sugar transport system, permease component
Theco_1535	COG3226	Transcriptional regulator
Theco_1537	COG1472	Belongs to the glycosyl hydrolase 3 family
Theco_1540	COG2972	Histidine kinase
Theco_1542	COG4209	transmembrane transport
Theco_1543	COG0395	ABC-type sugar transport system, permease component
Theco_1549	COG4124	Belongs to the glycosyl hydrolase 26 family
Theco_1552	COG1940	carbohydrate kinase activity
Theco_1553	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Theco_1558	COG0778	Nitroreductase
Theco_1559	COG3973	AAA domain
Theco_1561	COG2814	Major facilitator Superfamily
Theco_1563	COG1968	undecaprenyl-diphosphatase activity
Theco_1564	COG0393	Putative heavy-metal-binding
Theco_1569	COG0714	Associated with various cellular activities
Theco_1574	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Theco_1575	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Theco_1576	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Theco_1577	COG1120	ATPase activity
Theco_1578	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Theco_1580	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Theco_1581	COG1643	Atp-dependent helicase
Theco_1591	COG0673	inositol 2-dehydrogenase activity
Theco_1592	COG3622	Belongs to the hyi family
Theco_1593	COG0534	Mate efflux family protein
Theco_1596	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Theco_1599	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Theco_1600	COG0622	Phosphoesterase
Theco_1601	COG1408	metallophosphoesterase
Theco_1607	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Theco_1608	COG0725	ABC transporter, periplasmic molybdate-binding protein
Theco_1609	COG1979	alcohol dehydrogenase
Theco_1611	COG0714	Associated with various cellular activities
Theco_1615	COG4974	Belongs to the 'phage' integrase family
Theco_1620	COG0395	ABC-type sugar transport system, permease component
Theco_1621	COG3275	phosphorelay sensor kinase activity
Theco_1622	COG0745	RESPONSE REGULATOR receiver
Theco_1623	COG1472	Belongs to the glycosyl hydrolase 3 family
Theco_1624	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Theco_1625	COG1940	carbohydrate kinase activity
Theco_1626	COG0363	glucosamine-6-phosphate deaminase activity
Theco_1632	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Theco_1633	COG0667	Aldo Keto reductase
Theco_1637	COG0517	IMP dehydrogenase activity
Theco_1637	COG4175	Glycine betaine
Theco_1638	COG1510	regulation of RNA biosynthetic process
Theco_1644	COG0640	Transcriptional regulator
Theco_1645	COG3409	Peptidoglycan-binding domain 1 protein
Theco_1645	COG3773	Cell wall hydrolase
Theco_1649	COG1733	regulation of RNA biosynthetic process
Theco_1651	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
Theco_1652	COG0395	ABC-type sugar transport system, permease component
Theco_1653	COG1175	transmembrane transport
Theco_1654	COG1653	transport
Theco_1655	COG2207	Transcriptional regulator
Theco_1655	COG4753	response regulator
Theco_1656	COG2972	Histidine kinase
Theco_1657	COG0697	spore germination
Theco_1663	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Theco_1665	COG0667	Aldo Keto reductase
Theco_1666	COG5263	repeat protein
Theco_1666	COG4193	domain, Protein
Theco_1668	COG1175	transmembrane transport
Theco_1669	COG3842	ATPase activity
Theco_1670	COG2182	Extracellular solute-binding protein
Theco_1671	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
Theco_1672	COG2340	Cysteine-rich secretory protein family
Theco_1673	COG2311	Membrane
Theco_1674	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Theco_1675	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Theco_1676	COG0583	DNA-binding transcription factor activity
Theco_1679	COG3546	catalase activity
Theco_1681	COG1227	inorganic diphosphatase activity
Theco_1683	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Theco_1687	COG4948	Mandelate Racemase Muconate Lactonizing
Theco_1688	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Theco_1689	COG0667	Aldo Keto reductase
Theco_1693	COG1929	Belongs to the glycerate kinase type-1 family
Theco_1696	COG0667	Aldo Keto reductase
Theco_1699	COG0492	ferredoxin-NADP+ reductase activity
Theco_1700	COG3458	cephalosporin-C deacetylase activity
Theco_1702	COG0674	pyruvate-flavodoxin oxidoreductase activity
Theco_1704	COG1028	Short-chain dehydrogenase reductase Sdr
Theco_1705	COG2258	MOSC domain
Theco_1712	COG0493	'glutamate synthase
Theco_1713	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
Theco_1714	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Theco_1715	COG1607	acyl-coa hydrolase
Theco_1721	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Theco_1722	COG2860	membrane
Theco_1724	COG3402	PFAM membrane-flanked domain
Theco_1725	COG3428	Bacterial PH domain
Theco_1726	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Theco_1726	COG0321	lipoyl(octanoyl) transferase activity
Theco_1728	COG0456	acetyltransferase
Theco_1729	COG0791	NLP P60 protein
Theco_1730	COG5002	protein histidine kinase activity
Theco_1730	COG3850	Histidine kinase
Theco_1731	COG0745	RESPONSE REGULATOR receiver
Theco_1732	COG2815	serine threonine protein kinase
Theco_1732	COG0515	serine threonine protein kinase
Theco_1733	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
Theco_1734	COG1119	ATPase activity
Theco_1737	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Theco_1739	COG1205	dead DEAH box helicase
Theco_1739	COG1111	helicase
Theco_1741	COG1234	tRNA 3'-trailer cleavage
Theco_1742	COG1410	methionine synthase
Theco_1742	COG0646	methionine synthase
Theco_1743	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
Theco_1746	COG4224	UPF0291 protein
Theco_1748	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Theco_1749	COG0174	glutamine synthetase
Theco_1750	COG0789	Transcriptional regulator
Theco_1751	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
Theco_1752	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Theco_1753	COG0464	growth
Theco_1756	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Theco_1757	COG1923	regulation of RNA biosynthetic process
Theco_1758	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Theco_1759	COG2521	methyltransferase
Theco_1759	COG2136	Putative SAM-dependent methyltransferase
Theco_1760	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Theco_1761	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Theco_1764	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Theco_1765	COG1116	anion transmembrane transporter activity
Theco_1766	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Theco_1767	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
Theco_1768	COG4918	Iron-sulphur cluster biosynthesis
Theco_1770	COG1547	Domain of unknown function (DUF309)
Theco_1773	COG3858	chitin binding
Theco_1777	COG0840	transmembrane signaling receptor activity
Theco_1781	COG1846	Transcriptional regulator
Theco_1782	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Theco_1783	COG0187	DNA topoisomerase II activity
Theco_1784	COG1132	(ABC) transporter
Theco_1785	COG1132	(ABC) transporter
Theco_1786	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
Theco_1788	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Theco_1791	COG0860	N-Acetylmuramoyl-L-alanine amidase
Theco_1792	COG0066	3-isopropylmalate dehydratase activity
Theco_1793	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Theco_1794	COG0583	DNA-binding transcription factor activity
Theco_1795	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Theco_1796	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Theco_1798	COG0436	Aminotransferase
Theco_1799	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Theco_1800	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Theco_1801	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Theco_1802	COG1850	ribulose-bisphosphate carboxylase activity
Theco_1803	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
Theco_1804	COG0235	Class ii aldolase
Theco_1805	COG3935	DnaD domain protein
Theco_1806	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Theco_1807	COG1250	3-hydroxyacyl-CoA dehydrogenase
Theco_1808	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Theco_1811	COG0402	S-adenosylhomocysteine deaminase activity
Theco_1812	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
Theco_1813	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Theco_1813	COG1199	ATP-dependent helicase activity
Theco_1815	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Theco_1816	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Theco_1817	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Theco_1818	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Theco_1818	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Theco_1820	COG0438	transferase activity, transferring glycosyl groups
Theco_1821	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Theco_1822	COG1803	Methylglyoxal synthase
Theco_1823	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Theco_1825	COG1694	Mazg nucleotide pyrophosphohydrolase
Theco_1826	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Theco_1828	COG4347	Protein of unknown function (DUF1405)
Theco_1830	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Theco_1835	COG0406	alpha-ribazole phosphatase activity
Theco_1838	COG0287	Prephenate dehydrogenase
Theco_1839	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Theco_1840	COG0159	tryptophan synthase activity
Theco_1841	COG0133	tryptophan synthase activity
Theco_1842	COG0135	phosphoribosylanthranilate isomerase activity
Theco_1843	COG0134	indole-3-glycerol-phosphate synthase activity
Theco_1844	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Theco_1846	COG4401	Chorismate mutase type I
Theco_1847	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Theco_1848	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Theco_1850	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Theco_1853	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
Theco_1854	COG0163	prenyltransferase activity
Theco_1855	COG0109	protoheme IX farnesyltransferase activity
Theco_1861	COG0776	regulation of translation
Theco_1862	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
Theco_1869	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Theco_1870	COG1160	GTP binding
Theco_1874	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Theco_1877	COG2959	enzyme of heme biosynthesis
Theco_1879	COG2339	peptidase activity
Theco_1880	COG4862	establishment of competence for transformation
Theco_1883	COG1408	metallophosphoesterase
Theco_1885	COG1266	CAAX protease self-immunity
Theco_1887	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Theco_1888	COG5002	protein histidine kinase activity
Theco_1889	COG0745	RESPONSE REGULATOR receiver
Theco_1890	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Theco_1891	COG1333	cytochrome c biogenesis protein
Theco_1892	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Theco_1893	COG1187	pseudouridine synthase activity
Theco_1894	COG0700	Nucleoside recognition
Theco_1895	COG2715	membrane protein required for spore maturation
Theco_1896	COG1686	Belongs to the peptidase S11 family
Theco_1897	COG3874	Sporulation protein YtfJ
Theco_1899	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Theco_1900	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Theco_1901	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Theco_1902	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Theco_1902	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Theco_1904	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Theco_1904	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Theco_1907	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Theco_1908	COG0019	diaminopimelate decarboxylase activity
Theco_1909	COG0697	spore germination
Theco_1913	COG3344	reverse transcriptase
Theco_1915	COG2172	sigma factor antagonist activity
Theco_1916	COG1366	Belongs to the anti-sigma-factor antagonist family
Theco_1917	COG1686	Belongs to the peptidase S11 family
Theco_1938	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Theco_1941	COG0735	belongs to the Fur family
Theco_1942	COG1300	Membrane
Theco_1943	COG1379	DNA repair
Theco_1952	COG2195	Cleaves the N-terminal amino acid of tripeptides
Theco_1954	COG0321	lipoyl(octanoyl) transferase activity
Theco_1955	COG0508	dehydrogenase complex catalyzes the overall conversion of
Theco_1956	COG0022	dehydrogenase e1 component
Theco_1957	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Theco_1958	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Theco_1962	COG0745	RESPONSE REGULATOR receiver
Theco_1963	COG0750	zinc metalloprotease
Theco_1964	COG0497	DNA recombination
Theco_1965	COG1438	arginine binding
Theco_1967	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Theco_1968	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Theco_1970	COG1722	exodeoxyribonuclease VII activity
Theco_1971	COG1570	exodeoxyribonuclease VII activity
Theco_1972	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Theco_1973	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Theco_1976	COG1302	Protein conserved in bacteria
Theco_1977	COG0439	Biotin carboxylase
Theco_1978	COG0511	ligase activity, forming carbon-carbon bonds
Theco_1986	COG3854	ATPases associated with a variety of cellular activities
Theco_1988	COG1809	phosphosulfolactate synthase activity
Theco_1989	COG2707	UPF0756 membrane protein
Theco_1991	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Theco_1992	COG0006	proline dipeptidase activity
Theco_1993	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Theco_1994	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Theco_1997	COG3872	metal-dependent enzyme
Theco_1999	COG1321	iron dependent repressor
Theco_2000	COG0785	Cytochrome C biogenesis protein
Theco_2001	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Theco_2002	COG1121	(ABC) transporter
Theco_2003	COG0803	Belongs to the bacterial solute-binding protein 9 family
Theco_2003	COG3443	Belongs to the bacterial solute-binding protein 9 family
Theco_2005	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Theco_2006	COG0735	belongs to the Fur family
Theco_2011	COG1132	(ABC) transporter
Theco_2015	COG1268	BioY protein
Theco_2016	COG4550	Control of competence regulator ComK, YlbF/YmcA
Theco_2017	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Theco_2018	COG4869	propanediol catabolic process
Theco_2019	COG1013	pyruvate-flavodoxin oxidoreductase activity
Theco_2020	COG0674	pyruvate-flavodoxin oxidoreductase activity
Theco_2020	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Theco_2022	COG2359	stage V sporulation protein S
Theco_2023	COG1692	metallophosphoesterase
Theco_2024	COG1418	mRNA catabolic process
Theco_2025	COG2137	regulation of response to DNA damage stimulus
Theco_2026	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Theco_2027	COG1546	Belongs to the CinA family
Theco_2027	COG1058	Belongs to the CinA family
Theco_2028	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Theco_2029	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Theco_2030	COG1666	GTP binding
Theco_2032	COG1426	Protein conserved in bacteria
Theco_2035	COG0300	oxidoreductase activity
Theco_2036	COG0612	Peptidase, M16
Theco_2037	COG0612	Peptidase, M16
Theco_2038	COG3409	Peptidoglycan-binding domain 1 protein
Theco_2038	COG3773	Cell wall hydrolase
Theco_2039	COG1674	ftsk spoiiie
Theco_2039	COG4980	gas vesicle protein
Theco_2041	COG0740	serine-type endopeptidase activity
Theco_2042	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Theco_2043	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Theco_2044	COG0527	aspartate kinase activity
Theco_2045	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Theco_2046	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Theco_2047	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Theco_2048	COG0756	dUTP diphosphatase activity
Theco_2049	COG0612	Peptidase, M16
Theco_2051	COG1185	polyribonucleotide nucleotidyltransferase activity
Theco_2052	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Theco_2053	COG0196	riboflavin kinase activity
Theco_2054	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Theco_2055	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Theco_2056	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Theco_2057	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Theco_2057	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Theco_2059	COG2740	Nucleic-acid-binding protein implicated in transcription termination
Theco_2060	COG0195	Participates in both transcription termination and antitermination
Theco_2061	COG0779	Required for maturation of 30S ribosomal subunits
Theco_2062	COG2176	DNA-directed DNA polymerase activity
Theco_2063	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Theco_2064	COG0750	zinc metalloprotease
Theco_2065	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Theco_2066	COG4589	Belongs to the CDS family
Theco_2067	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Theco_2068	COG0233	cytoplasmic translational termination
Theco_2069	COG0528	UMP kinase activity
Theco_2071	COG0052	Belongs to the universal ribosomal protein uS2 family
Theco_2076	COG1191	sigma factor activity
Theco_2078	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Theco_2079	COG1776	CheC inhibitor of MCP methylation
Theco_2080	COG0835	chemotaxis
Theco_2081	COG2198	Histidine kinase
Theco_2081	COG0643	Histidine kinase
Theco_2082	COG2201	protein-glutamate methylesterase activity
Theco_2083	COG0455	bacterial-type flagellum organization
Theco_2084	COG1419	protein localization to endoplasmic reticulum
Theco_2085	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Theco_2086	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Theco_2087	COG1684	flagellar biosynthetic protein fliR
Theco_2088	COG1987	bacterial-type flagellum assembly
Theco_2089	COG1338	Plays a role in the flagellum-specific transport system
Theco_2091	COG2201	protein-glutamate methylesterase activity
Theco_2092	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Theco_2092	COG1776	CheC inhibitor of MCP methylation
Theco_2093	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Theco_2096	COG4786	Flagellar basal body rod
Theco_2098	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Theco_2102	COG1157	protein secretion by the type III secretion system
Theco_2104	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Theco_2105	COG1766	The M ring may be actively involved in energy transduction
Theco_2106	COG1677	Flagellar hook-basal body complex protein FliE
Theco_2107	COG1558	bacterial-type flagellum-dependent cell motility
Theco_2108	COG1815	bacterial-type flagellum-dependent cell motility
Theco_2110	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Theco_2111	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Theco_2112	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
Theco_2113	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Theco_2114	COG0758	DNA mediated transformation
Theco_2114	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Theco_2115	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Theco_2116	COG0045	succinate-CoA ligase (ADP-forming) activity
Theco_2119	COG0792	nuclease activity
Theco_2122	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Theco_2127	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Theco_2128	COG1837	Belongs to the UPF0109 family
Theco_2129	COG0228	four-way junction DNA binding
Theco_2130	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Theco_2131	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
Theco_2132	COG0552	protein localization to endoplasmic reticulum
Theco_2133	COG1196	nuclear chromosome segregation
Theco_2134	COG0571	ribonuclease III activity
Theco_2135	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Theco_2136	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Theco_2137	COG1028	Short-chain dehydrogenase reductase Sdr
Theco_2138	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Theco_2139	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Theco_2140	COG0416	fatty acid biosynthetic process
Theco_2141	COG1349	DNA-binding transcription factor activity
Theco_2142	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Theco_2144	COG1323	Belongs to the UPF0348 family
Theco_2145	COG3480	Lon protease (S16) C-terminal proteolytic domain
Theco_2146	COG3314	Sporulation integral membrane protein YlbJ
Theco_2147	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Theco_2148	COG0742	ribosomal rna small subunit methyltransferase
Theco_2149	COG3344	reverse transcriptase
Theco_2153	COG0084	hydrolase, TatD family'
Theco_2155	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Theco_2157	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Theco_2158	COG0457	Tetratricopeptide repeat
Theco_2158	COG0463	Glycosyl transferase, family 2
Theco_2161	COG1086	Polysaccharide biosynthesis protein
Theco_2166	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Theco_2167	COG2135	peptidase activity
Theco_2169	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Theco_2170	COG1307	EDD domain protein, DegV family
Theco_2171	COG1461	Dihydroxyacetone kinase
Theco_2172	COG1302	Protein conserved in bacteria
Theco_2173	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Theco_2174	COG3344	reverse transcriptase
Theco_2178	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Theco_2179	COG1162	GTPase activity
Theco_2180	COG0515	serine threonine protein kinase
Theco_2180	COG2815	serine threonine protein kinase
Theco_2181	COG0631	protein serine/threonine phosphatase activity
Theco_2182	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Theco_2183	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Theco_2183	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Theco_2184	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Theco_2185	COG0242	peptide deformylase activity
Theco_2186	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Theco_2187	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Theco_2188	COG1758	RNA polymerase activity
Theco_2189	COG0194	GDP metabolic process
Theco_2190	COG2052	Domain of unknown function (DUF370)
Theco_2191	COG0646	methionine synthase
Theco_2191	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Theco_2193	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Theco_2195	COG0613	PHP domain protein
Theco_2196	COG0583	DNA-binding transcription factor activity
Theco_2201	COG1061	Type III restriction enzyme res subunit
Theco_2202	COG0228	four-way junction DNA binding
Theco_2203	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
Theco_2204	COG1473	amidohydrolase
Theco_2206	COG0772	Belongs to the SEDS family
Theco_2207	COG1302	Protein conserved in bacteria
Theco_2208	COG4838	Belongs to the UPF0358 family
Theco_2210	COG2309	aminopeptidase activity
Theco_2212	COG2199	diguanylate cyclase activity
Theco_2212	COG2203	Gaf domain
Theco_2213	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Theco_2214	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Theco_2215	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Theco_2216	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Theco_2220	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Theco_2222	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Theco_2222	COG1648	precorrin-2 dehydrogenase activity
Theco_2224	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Theco_2227	COG1832	CoA-binding protein
Theco_2228	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Theco_2229	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Theco_2230	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Theco_2231	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Theco_2233	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Theco_2234	COG1070	Carbohydrate kinase
Theco_2237	COG1982	Orn Lys Arg decarboxylase major
Theco_2242	COG1234	tRNA 3'-trailer cleavage
Theco_2258	COG1136	(ABC) transporter
Theco_2258	COG0577	efflux transmembrane transporter activity
Theco_2261	COG1136	(ABC) transporter
Theco_2261	COG0577	efflux transmembrane transporter activity
Theco_2264	COG1131	(ABC) transporter
Theco_2266	COG4124	Belongs to the glycosyl hydrolase 26 family
Theco_2267	COG4124	Belongs to the glycosyl hydrolase 26 family
Theco_2268	COG0395	ABC-type sugar transport system, permease component
Theco_2269	COG1175	transmembrane transport
Theco_2273	COG0395	ABC-type sugar transport system, permease component
Theco_2275	COG1653	transport
Theco_2277	COG1609	Transcriptional regulator
Theco_2281	COG1136	(ABC) transporter
Theco_2285	COG1175	transmembrane transport
Theco_2286	COG0395	ABC-type sugar transport system, permease component
Theco_2287	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Theco_2288	COG0284	orotidine-5'-phosphate decarboxylase activity
Theco_2289	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Theco_2291	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Theco_2292	COG0540	Belongs to the ATCase OTCase family
Theco_2295	COG0564	pseudouridine synthase activity
Theco_2296	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Theco_2297	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Theco_2301	COG3599	regulation of cell shape
Theco_2302	COG2302	S4 RNA-binding domain
Theco_2303	COG0762	integral membrane protein
Theco_2304	COG1799	cell septum assembly
Theco_2305	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Theco_2307	COG1873	PFAM PRC-barrel domain
Theco_2309	COG1191	sigma factor activity
Theco_2310	COG1191	sigma factor activity
Theco_2312	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Theco_2313	COG0849	cell division
Theco_2314	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Theco_2315	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Theco_2316	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Theco_2317	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Theco_2318	COG0772	Belongs to the SEDS family
Theco_2319	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Theco_2320	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Theco_2321	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Theco_2322	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Theco_2323	COG0768	penicillin binding
Theco_2324	COG0768	penicillin binding
Theco_2326	COG0275	rRNA processing
Theco_2327	COG2001	Belongs to the MraZ family
Theco_2328	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Theco_2329	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
Theco_2331	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Theco_2336	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Theco_2339	COG1316	TRANSCRIPTIONal
Theco_2344	COG0861	Integral membrane protein TerC family
Theco_2345	COG0861	Integral membrane protein TerC family
Theco_2346	COG0301	tRNA thio-modification
Theco_2347	COG1104	cysteine desulfurase activity
Theco_2348	COG0741	lytic transglycosylase activity
Theco_2354	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Theco_2355	COG2384	SAM-dependent methyltransferase
Theco_2358	COG0358	DNA primase activity
Theco_2359	COG1671	Belongs to the UPF0178 family
Theco_2360	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Theco_2361	COG0751	glycine-tRNA ligase activity
Theco_2362	COG0752	glycyl-tRNA synthetase alpha subunit
Theco_2363	COG1381	Involved in DNA repair and RecF pathway recombination
Theco_2365	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Theco_2367	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Theco_2368	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Theco_2369	COG1480	7TM receptor with intracellular HD hydrolase
Theco_2370	COG1702	phosphate starvation-inducible protein PhoH
Theco_2374	COG4864	UPF0365 protein
Theco_2375	COG1030	water channel activity
Theco_2378	COG1610	YqeY-like protein
Theco_2379	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Theco_2380	COG0537	adenosine 5'-monophosphoramidase activity
Theco_2383	COG0419	ATPase involved in DNA repair
Theco_2385	COG0420	3'-5' exonuclease activity
Theco_2386	COG1074	ATP-dependent DNA helicase activity
Theco_2387	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
Theco_2388	COG0584	glycerophosphoryl diester phosphodiesterase
Theco_2389	COG3250	beta-galactosidase activity
Theco_2390	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Theco_2391	COG1335	isochorismatase
Theco_2393	COG1283	sodium-dependent phosphate transmembrane transporter activity
Theco_2394	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Theco_2396	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Theco_2397	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Theco_2398	COG1994	Peptidase M50
Theco_2399	COG2264	protein methyltransferase activity
Theco_2403	COG0443	Heat shock 70 kDa protein
Theco_2405	COG1420	regulation of RNA biosynthetic process
Theco_2406	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Theco_2408	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Theco_2409	COG0481	GTPase activity
Theco_2411	COG0860	N-Acetylmuramoyl-L-alanine amidase
Theco_2413	COG0268	Binds directly to 16S ribosomal RNA
Theco_2414	COG1466	dna polymerase III delta subunit
Theco_2416	COG1595	DNA-templated transcription, initiation
Theco_2417	COG0658	competence protein
Theco_2417	COG2333	competence protein COMEC
Theco_2419	COG1555	photosystem II stabilization
Theco_2420	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Theco_2421	COG0495	leucyl-tRNA aminoacylation
Theco_2423	COG2226	methyltransferase
Theco_2424	COG2996	Protein conserved in bacteria
Theco_2425	COG0799	negative regulation of ribosome biogenesis
Theco_2426	COG1713	HD superfamily hydrolase involved in NAD metabolism
Theco_2427	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Theco_2428	COG1534	Rna-binding protein
Theco_2429	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Theco_2430	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
Theco_2431	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
Theco_2434	COG0714	Associated with various cellular activities
Theco_2435	COG2826	transposase and inactivated derivatives, IS30 family
Theco_2439	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Theco_2444	COG1609	Transcriptional regulator
Theco_2449	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Theco_2450	COG1126	abc transporter atp-binding protein
Theco_2451	COG0765	amino acid transport
Theco_2452	COG0765	amino acid transport
Theco_2453	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Theco_2455	COG0583	DNA-binding transcription factor activity
Theco_2456	COG0431	NADPH-dependent FMN reductase
Theco_2457	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Theco_2458	COG1191	sigma factor activity
Theco_2460	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Theco_2461	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Theco_2468	COG2972	Histidine kinase
Theco_2470	COG4753	response regulator
Theco_2470	COG2207	Transcriptional regulator
Theco_2471	COG0829	nickel cation binding
Theco_2472	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Theco_2473	COG0830	nickel cation binding
Theco_2475	COG0831	urea catabolic process
Theco_2477	COG0129	dihydroxy-acid dehydratase activity
Theco_2478	COG0726	polysaccharide deacetylase
Theco_2479	COG0628	permease
Theco_2480	COG0768	penicillin binding
Theco_2484	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Theco_2487	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Theco_2488	COG4472	Bacterial protein of unknown function (DUF965)
Theco_2489	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Theco_2490	COG0628	permease
Theco_2493	COG1104	cysteine desulfurase activity
Theco_2494	COG1959	2 iron, 2 sulfur cluster binding
Theco_2495	COG0482	sulfurtransferase activity
Theco_2496	COG1253	flavin adenine dinucleotide binding
Theco_2497	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Theco_2499	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Theco_2500	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Theco_2501	COG0124	histidyl-tRNA synthetase
Theco_2502	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Theco_2504	COG1490	D-aminoacyl-tRNA deacylase activity
Theco_2505	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Theco_2506	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Theco_2507	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Theco_2507	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Theco_2510	COG2244	polysaccharide biosynthetic process
Theco_2511	COG2323	membrane
Theco_2514	COG1862	Preprotein translocase
Theco_2517	COG2385	sporulation resulting in formation of a cellular spore
Theco_2519	COG2255	four-way junction helicase activity
Theco_2520	COG0632	four-way junction helicase activity
Theco_2521	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Theco_2526	COG3344	reverse transcriptase
Theco_2527	COG1388	LysM domain
Theco_2527	COG0741	lytic transglycosylase activity
Theco_2528	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Theco_2529	COG0077	Prephenate dehydratase
Theco_2530	COG0083	homoserine kinase activity
Theco_2531	COG0460	homoserine dehydrogenase
Theco_2532	COG4492	Belongs to the UPF0735 family
Theco_2533	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Theco_2535	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Theco_2536	COG2868	ribosomal protein
Theco_2537	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Theco_2538	COG1530	ribonuclease E activity
Theco_2539	COG1994	Peptidase M50
Theco_2542	COG0772	Belongs to the SEDS family
Theco_2543	COG2894	cell division
Theco_2544	COG0850	regulation of cytokinetic process
Theco_2546	COG1792	Involved in formation and maintenance of cell shape
Theco_2547	COG1077	Cell shape determining protein MreB Mrl
Theco_2548	COG2003	Belongs to the UPF0758 family
Theco_2559	COG0424	maF-like protein
Theco_2562	COG2340	Cysteine-rich secretory protein family
Theco_2563	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Theco_2564	COG0285	dihydrofolate synthase activity
Theco_2565	COG0525	valine-tRNA ligase activity
Theco_2566	COG1388	LysM domain
Theco_2567	COG0564	pseudouridine synthase activity
Theco_2568	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Theco_2570	COG0113	porphobilinogen synthase activity
Theco_2573	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Theco_2573	COG1648	precorrin-2 dehydrogenase activity
Theco_2574	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Theco_2576	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Theco_2578	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Theco_2580	COG1067	ATP-dependent peptidase activity
Theco_2580	COG0470	DNA polymerase III
Theco_2581	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Theco_2582	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Theco_2583	COG0740	serine-type endopeptidase activity
Theco_2584	COG0544	peptidyl-prolyl cis-trans isomerase activity
Theco_2587	COG0367	asparagine synthase
Theco_2589	COG2814	Major facilitator Superfamily
Theco_2594	COG1172	Belongs to the binding-protein-dependent transport system permease family
Theco_2595	COG1129	ABC transporter
Theco_2596	COG1879	ABC-type sugar transport system periplasmic component
Theco_2601	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Theco_2601	COG1522	sequence-specific DNA binding
Theco_2604	COG0367	asparagine synthase
Theco_2605	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Theco_2606	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Theco_2607	COG5401	PFAM Sporulation and spore germination
Theco_2608	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Theco_2609	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Theco_2612	COG0039	L-malate dehydrogenase activity
Theco_2613	COG0538	isocitrate dehydrogenase activity
Theco_2614	COG0372	Belongs to the citrate synthase family
Theco_2617	COG0825	malonyl-CoA metabolic process
Theco_2618	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Theco_2620	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Theco_2621	COG0587	DNA-directed DNA polymerase activity
Theco_2626	COG4109	DRTGG domain
Theco_2628	COG4399	Belongs to the UPF0754 family
Theco_2629	COG0189	ligase activity
Theco_2630	COG0189	ligase activity
Theco_2631	COG0189	ligase activity
Theco_2632	COG0189	ligase activity
Theco_2634	COG0189	ligase activity
Theco_2636	COG0402	S-adenosylhomocysteine deaminase activity
Theco_2638	COG2249	NAD(P)H dehydrogenase (quinone) activity
Theco_2639	COG1733	regulation of RNA biosynthetic process
Theco_2640	COG3546	catalase activity
Theco_2644	COG0535	radical SAM domain protein
Theco_2645	COG0737	Belongs to the 5'-nucleotidase family
Theco_2646	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Theco_2647	COG0314	molybdopterin synthase activity
Theco_2648	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Theco_2649	COG2199	diguanylate cyclase activity
Theco_2649	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Theco_2652	COG1705	Flagellar rod assembly protein muramidase FlgJ
Theco_2656	COG1595	DNA-templated transcription, initiation
Theco_2662	COG0719	Fe-S assembly protein
Theco_2663	COG0822	iron-sulfur transferase activity
Theco_2664	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Theco_2665	COG0719	Fe-S assembly protein
Theco_2666	COG0396	ATPase activity
Theco_2670	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
Theco_2671	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Theco_2672	COG3377	Domain of unknown function (DUF1805)
Theco_2675	COG2363	Small membrane protein
Theco_2677	COG2718	Belongs to the UPF0229 family
Theco_2679	COG0330	HflC and HflK could
Theco_2680	COG0330	HflC and HflK could
Theco_2681	COG0840	transmembrane signaling receptor activity
Theco_2682	COG2719	SpoVR family
Theco_2683	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Theco_2684	COG2766	serine protein kinase
Theco_2687	COG2002	toxin-antitoxin pair type II binding
Theco_2688	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Theco_2689	COG0745	RESPONSE REGULATOR receiver
Theco_2692	COG0174	glutamine synthetase
Theco_2695	COG1309	transcriptional regulator
Theco_2696	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Theco_2697	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Theco_2698	COG3850	Histidine kinase
Theco_2698	COG5002	protein histidine kinase activity
Theco_2699	COG0745	RESPONSE REGULATOR receiver
Theco_2700	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Theco_2702	COG2197	response regulator
Theco_2703	COG4585	Histidine kinase
Theco_2704	COG4758	membrane
Theco_2705	COG0840	transmembrane signaling receptor activity
Theco_2706	COG1595	DNA-templated transcription, initiation
Theco_2707	COG3584	3D domain protein
Theco_2708	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Theco_2710	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Theco_2711	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Theco_2712	COG0626	cystathionine gamma-synthase activity
Theco_2715	COG0598	Magnesium transport protein CorA
Theco_2716	COG2270	Major facilitator Superfamily
Theco_2717	COG0583	DNA-binding transcription factor activity
Theco_2720	COG1733	regulation of RNA biosynthetic process
Theco_2721	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Theco_2722	COG1053	succinate dehydrogenase
Theco_2723	COG2009	succinate dehydrogenase
Theco_2724	COG2826	transposase and inactivated derivatives, IS30 family
Theco_2725	COG0583	DNA-binding transcription factor activity
Theco_2726	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Theco_2729	COG3344	reverse transcriptase
Theco_2733	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Theco_2734	COG4208	sulfate ABC transporter
Theco_2735	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
Theco_2736	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
Theco_2738	COG1484	DNA-dependent DNA replication
Theco_2740	COG0596	Alpha beta hydrolase
Theco_2744	COG1252	NADH dehydrogenase
Theco_2745	COG0492	ferredoxin-NADP+ reductase activity
Theco_2748	COG0189	ligase activity
Theco_2751	COG1230	cation diffusion facilitator family transporter
Theco_2752	COG1126	abc transporter atp-binding protein
Theco_2754	COG0765	amino acid transport
Theco_2755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Theco_2756	COG0477	Major facilitator Superfamily
Theco_2757	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
Theco_2757	COG0662	Cupin 2, conserved barrel domain protein
Theco_2759	COG1063	alcohol dehydrogenase
Theco_2760	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Theco_2760	COG3711	transcriptional antiterminator
Theco_2761	COG2213	PTS system mannitol-specific
Theco_2762	COG1063	alcohol dehydrogenase
Theco_2763	COG0395	ABC-type sugar transport system, permease component
Theco_2767	COG2814	Major facilitator Superfamily
Theco_2771	COG5002	protein histidine kinase activity
Theco_2773	COG3534	alpha-L-arabinofuranosidase
Theco_2774	COG4977	sequence-specific DNA binding
Theco_2779	COG2207	Transcriptional regulator
Theco_2779	COG4753	response regulator
Theco_2781	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
Theco_2784	COG0475	glutathione-regulated potassium exporter activity
Theco_2785	COG0697	spore germination
Theco_2791	COG2010	Cytochrome c
Theco_2792	COG0697	spore germination
Theco_2795	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
Theco_2797	COG0410	ABC transporter
Theco_2798	COG0411	ABC transporter
Theco_2801	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
Theco_2810	COG1061	Type III restriction enzyme res subunit
Theco_2815	COG2132	Multicopper oxidase
Theco_2816	COG5002	protein histidine kinase activity
Theco_2817	COG0745	RESPONSE REGULATOR receiver
Theco_2821	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Theco_2826	COG2197	response regulator
Theco_2827	COG2972	Histidine kinase
Theco_2832	COG1917	Cupin 2, conserved barrel domain protein
Theco_2832	COG2207	Transcriptional regulator
Theco_2835	COG0395	ABC-type sugar transport system, permease component
Theco_2836	COG4209	transmembrane transport
Theco_2839	COG1131	(ABC) transporter
Theco_2844	COG2814	Major facilitator Superfamily
Theco_2846	COG0789	Transcriptional regulator
Theco_2848	COG3507	Belongs to the glycosyl hydrolase 43 family
Theco_2849	COG3279	Response regulator of the LytR AlgR family
Theco_2850	COG2972	Histidine kinase
Theco_2856	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Theco_2857	COG0395	ABC-type sugar transport system, permease component
Theco_2858	COG1175	transmembrane transport
Theco_2862	COG0395	ABC-type sugar transport system, permease component
Theco_2863	COG1175	transmembrane transport
Theco_2867	COG0534	Mate efflux family protein
Theco_2869	COG1595	DNA-templated transcription, initiation
Theco_2871	COG0789	Transcriptional regulator
Theco_2872	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Theco_2874	COG1028	Short-chain dehydrogenase reductase Sdr
Theco_2875	COG2814	Major facilitator Superfamily
Theco_2876	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
Theco_2878	COG2814	Major facilitator Superfamily
Theco_2880	COG0596	Alpha beta hydrolase
Theco_2882	COG0431	NADPH-dependent FMN reductase
Theco_2883	COG2197	response regulator
Theco_2884	COG2203	Gaf domain
Theco_2884	COG4585	Histidine kinase
Theco_2885	COG2217	Heavy metal translocating P-type atpase
Theco_2889	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
Theco_2890	COG4988	ABC transporter
Theco_2891	COG1294	oxidase, subunit
Theco_2892	COG1271	oxidase subunit
Theco_2913	COG0735	belongs to the Fur family
Theco_2914	COG1285	pathogenesis
Theco_2915	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Theco_2916	COG0154	amidase activity
Theco_2917	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Theco_2926	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
Theco_2930	COG2337	Toxic component of a toxin-antitoxin (TA) module
Theco_2931	COG0864	Transcriptional regulator
Theco_2932	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Theco_2933	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Theco_2938	COG0582	viral genome integration into host DNA
Theco_2941	COG3206	protein involved in exopolysaccharide biosynthesis
Theco_2949	COG4372	Transposase
Theco_2950	COG0745	RESPONSE REGULATOR receiver
Theco_2952	COG3507	Belongs to the glycosyl hydrolase 43 family
Theco_2956	COG0395	ABC-type sugar transport system, permease component
Theco_2957	COG4209	transmembrane transport
Theco_2958	COG3250	beta-galactosidase activity
Theco_2959	COG2723	6-phospho-beta-galactosidase activity
Theco_2964	COG1587	Uroporphyrinogen-III synthase
Theco_2965	COG0583	DNA-binding transcription factor activity
Theco_2967	COG2146	nitrite reductase [NAD(P)H] activity
Theco_2968	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Theco_2969	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Theco_2969	COG1648	precorrin-2 dehydrogenase activity
Theco_2970	COG2116	formate transmembrane transporter activity
Theco_2972	COG1523	belongs to the glycosyl hydrolase 13 family
Theco_2981	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Theco_2982	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Theco_2983	COG1321	iron dependent repressor
Theco_2983	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Theco_2984	COG1121	(ABC) transporter
Theco_2985	COG0803	Belongs to the bacterial solute-binding protein 9 family
Theco_2986	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Theco_2991	COG2267	carboxylic ester hydrolase activity
Theco_2992	COG2081	HI0933 family
Theco_2994	COG1172	Belongs to the binding-protein-dependent transport system permease family
Theco_2995	COG1172	Belongs to the binding-protein-dependent transport system permease family
Theco_2996	COG1129	ABC transporter
Theco_2997	COG2207	Transcriptional regulator
Theco_2998	COG2972	Histidine kinase
Theco_3002	COG1131	(ABC) transporter
Theco_3007	COG2801	Transposase and inactivated derivatives
Theco_3010	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Theco_3011	COG0456	acetyltransferase
Theco_3012	COG1214	PFAM Peptidase M22, glycoprotease
Theco_3013	COG0802	atpase or kinase
Theco_3014	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Theco_3015	COG0726	polysaccharide deacetylase
Theco_3017	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
Theco_3018	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Theco_3019	COG1793	dna ligase
Theco_3021	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Theco_3022	COG0739	heme binding
Theco_3022	COG1196	nuclear chromosome segregation
Theco_3022	COG0741	lytic transglycosylase activity
Theco_3026	COG0730	response to heat
Theco_3029	COG1181	Belongs to the D-alanine--D-alanine ligase family
Theco_3031	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Theco_3034	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Theco_3035	COG3383	formate dehydrogenase (NAD+) activity
Theco_3035	COG0243	molybdopterin cofactor binding
Theco_3036	COG1414	Transcriptional regulator
Theco_3038	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Theco_3041	COG1285	pathogenesis
Theco_3042	COG0647	UMP catabolic process
Theco_3043	COG1234	tRNA 3'-trailer cleavage
Theco_3046	COG1653	transport
Theco_3048	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Theco_3049	COG0302	gtp cyclohydrolase
Theco_3052	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Theco_3053	COG0328	RNA-DNA hybrid ribonuclease activity
Theco_3055	COG0456	acetyltransferase
Theco_3057	COG2378	regulation of single-species biofilm formation
Theco_3059	COG4470	Protein conserved in bacteria
Theco_3060	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Theco_3061	COG0739	heme binding
Theco_3064	COG0673	inositol 2-dehydrogenase activity
Theco_3066	COG0673	inositol 2-dehydrogenase activity
Theco_3070	COG1253	flavin adenine dinucleotide binding
Theco_3071	COG1309	transcriptional regulator
Theco_3072	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Theco_3073	COG0492	ferredoxin-NADP+ reductase activity
Theco_3074	COG2323	membrane
Theco_3075	COG2814	Major facilitator Superfamily
Theco_3077	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Theco_3085	COG0640	Transcriptional regulator
Theco_3087	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Theco_3088	COG0569	domain protein
Theco_3090	COG0151	Belongs to the GarS family
Theco_3092	COG0138	bifunctional purine biosynthesis protein purh
Theco_3093	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Theco_3094	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Theco_3095	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Theco_3096	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Theco_3097	COG0047	phosphoribosylformylglycinamidine synthase activity
Theco_3098	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Theco_3099	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Theco_3100	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Theco_3101	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Theco_3102	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Theco_3110	COG2972	Histidine kinase
Theco_3111	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Theco_3111	COG2207	Transcriptional regulator
Theco_3114	COG3547	Transposase (IS116 IS110 IS902 family)
Theco_3125	COG3547	Transposase (IS116 IS110 IS902 family)
Theco_3126	COG3547	Transposase (IS116 IS110 IS902 family)
Theco_3127	COG3547	Transposase (IS116 IS110 IS902 family)
Theco_3129	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Theco_3130	COG1518	maintenance of DNA repeat elements
Theco_3137	COG2801	Transposase and inactivated derivatives
Theco_3138	COG2801	Transposase and inactivated derivatives
Theco_3140	COG3547	Transposase (IS116 IS110 IS902 family)
Theco_3142	COG2252	PERMEase
Theco_3144	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Theco_3145	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Theco_3145	COG0519	Catalyzes the synthesis of GMP from XMP
Theco_3146	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Theco_3151	COG4555	ABC transporter
Theco_3153	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Theco_3154	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
Theco_3155	COG1131	(ABC) transporter
Theco_3157	COG1396	sequence-specific DNA binding
Theco_3158	COG0069	glutamate synthase activity
Theco_3158	COG0070	glutamate synthase
Theco_3158	COG0067	glutamate synthase
Theco_3160	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Theco_3161	COG1396	sequence-specific DNA binding
Theco_3162	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Theco_3163	COG0110	maltose O-acetyltransferase activity
Theco_3164	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Theco_3166	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Theco_3172	COG1216	Glycosyl transferase, family 2
Theco_3179	COG1215	transferase activity, transferring glycosyl groups
Theco_3181	COG0438	transferase activity, transferring glycosyl groups
Theco_3182	COG0438	transferase activity, transferring glycosyl groups
Theco_3183	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Theco_3184	COG1086	Polysaccharide biosynthesis protein
Theco_3185	COG1132	(ABC) transporter
Theco_3188	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Theco_3193	COG0489	protein tyrosine kinase activity
Theco_3194	COG3944	biosynthesis protein
Theco_3196	COG1396	sequence-specific DNA binding
Theco_3197	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Theco_3198	COG0488	(ABC) transporter
Theco_3199	COG0673	inositol 2-dehydrogenase activity
Theco_3200	COG1413	lyase activity
Theco_3204	COG0105	UTP biosynthetic process
Theco_3207	COG3940	Belongs to the glycosyl hydrolase 43 family
Theco_3208	COG3507	Belongs to the glycosyl hydrolase 43 family
Theco_3209	COG0395	ABC-type sugar transport system, permease component
Theco_3210	COG1175	transmembrane transport
Theco_3215	COG0667	Aldo Keto reductase
Theco_3216	COG1063	alcohol dehydrogenase
Theco_3224	COG2207	Transcriptional regulator
Theco_3224	COG4753	response regulator
Theco_3225	COG2972	Histidine kinase
Theco_3227	COG0395	ABC-type sugar transport system, permease component
Theco_3228	COG4209	transmembrane transport
Theco_3233	COG0395	ABC-type sugar transport system, permease component
Theco_3235	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Theco_3240	COG0647	UMP catabolic process
Theco_3241	COG1349	DNA-binding transcription factor activity
Theco_3243	COG0800	Aldolase
Theco_3245	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Theco_3246	COG0432	Pfam Uncharacterised protein family UPF0047
Theco_3249	COG0194	GDP metabolic process
Theco_3250	COG0783	Belongs to the Dps family
Theco_3252	COG2197	response regulator
Theco_3254	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Theco_3255	COG1882	Formate acetyltransferase
Theco_3256	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Theco_3257	COG0667	Aldo Keto reductase
Theco_3258	COG1733	regulation of RNA biosynthetic process
Theco_3259	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
Theco_3262	COG1696	Membrane protein involved in D-alanine export
Theco_3264	COG2207	Transcriptional regulator
Theco_3264	COG4753	response regulator
Theco_3265	COG2972	Histidine kinase
Theco_3267	COG0395	ABC-type sugar transport system, permease component
Theco_3268	COG4209	transmembrane transport
Theco_3269	COG0667	Aldo Keto reductase
Theco_3273	COG1132	(ABC) transporter
Theco_3274	COG1132	(ABC) transporter
Theco_3275	COG0477	Major facilitator Superfamily
Theco_3276	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Theco_3278	COG1368	sulfuric ester hydrolase activity
Theco_3280	COG1842	Phage shock protein A
Theco_3283	COG5002	protein histidine kinase activity
Theco_3285	COG0534	Mate efflux family protein
Theco_3292	COG3547	Transposase (IS116 IS110 IS902 family)
Theco_3305	COG1131	(ABC) transporter
Theco_3306	COG2723	6-phospho-beta-galactosidase activity
Theco_3310	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Theco_3312	COG1172	Belongs to the binding-protein-dependent transport system permease family
Theco_3313	COG1129	ABC transporter
Theco_3318	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Theco_3319	COG0395	ABC-type sugar transport system, permease component
Theco_3320	COG1175	transmembrane transport
Theco_3321	COG1653	transport
Theco_3322	COG1609	Transcriptional regulator
Theco_3323	COG1509	lysine 2,3-aminomutase activity
Theco_3324	COG2720	vancomycin resistance protein
Theco_3325	COG0686	Belongs to the AlaDH PNT family
Theco_3326	COG1609	Transcriptional regulator
Theco_3330	COG0395	ABC-type sugar transport system, permease component
Theco_3333	COG0395	ABC-type sugar transport system, permease component
Theco_3334	COG4209	transmembrane transport
Theco_3336	COG2207	Transcriptional regulator
Theco_3336	COG4753	response regulator
Theco_3337	COG3275	phosphorelay sensor kinase activity
Theco_3338	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Theco_3341	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Theco_3345	COG2972	Histidine kinase
Theco_3346	COG4753	response regulator
Theco_3346	COG2207	Transcriptional regulator
Theco_3348	COG1175	transmembrane transport
Theco_3349	COG0395	ABC-type sugar transport system, permease component
Theco_3351	COG4120	Belongs to the binding-protein-dependent transport system permease family
Theco_3360	COG4753	response regulator
Theco_3360	COG2207	Transcriptional regulator
Theco_3361	COG2972	Histidine kinase
Theco_3362	COG1501	Belongs to the glycosyl hydrolase 31 family
Theco_3363	COG0395	ABC-type sugar transport system, permease component
Theco_3364	COG1175	transmembrane transport
Theco_3376	COG1874	Beta-galactosidase
Theco_3378	COG0395	ABC-type sugar transport system, permease component
Theco_3379	COG4209	transmembrane transport
Theco_3381	COG4753	response regulator
Theco_3381	COG2207	Transcriptional regulator
Theco_3382	COG3275	phosphorelay sensor kinase activity
Theco_3384	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Theco_3385	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Theco_3399	COG1078	dGTPase activity
Theco_3408	COG0732	type I restriction modification DNA specificity domain
Theco_3410	COG0745	RESPONSE REGULATOR receiver
Theco_3411	COG2205	protein histidine kinase activity
Theco_3412	COG1136	(ABC) transporter
Theco_3413	COG0577	efflux transmembrane transporter activity
Theco_3414	COG3300	MHYT domain
Theco_3414	COG5001	Diguanylate cyclase
Theco_3419	COG0697	spore germination
Theco_3424	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
Theco_3425	COG0745	RESPONSE REGULATOR receiver
Theco_3426	COG5002	protein histidine kinase activity
Theco_3432	COG1846	Transcriptional regulator
Theco_3436	COG1063	alcohol dehydrogenase
Theco_3441	COG1116	anion transmembrane transporter activity
Theco_3445	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Theco_3446	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Theco_3447	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Theco_3463	COG5609	conserved protein (DUF2294)
Theco_3465	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Theco_3466	COG1742	UPF0060 membrane protein
Theco_3468	COG0798	PFAM Bile acid sodium symporter
Theco_3469	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Theco_3470	COG0475	glutathione-regulated potassium exporter activity
Theco_3472	COG0861	Integral membrane protein TerC family
Theco_3473	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Theco_3474	COG3002	Belongs to the UPF0753 family
Theco_3475	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Theco_3478	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Theco_3479	COG0557	exoribonuclease II activity
Theco_3480	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Theco_3483	COG0148	phosphopyruvate hydratase activity
Theco_3484	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Theco_3485	COG0149	triose-phosphate isomerase activity
Theco_3486	COG0126	phosphoglycerate kinase activity
Theco_3491	COG0740	serine-type endopeptidase activity
Theco_3493	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Theco_3494	COG1481	regulation of sporulation
Theco_3495	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Theco_3496	COG1660	Displays ATPase and GTPase activities
Theco_3497	COG1940	carbohydrate kinase activity
Theco_3498	COG1309	transcriptional regulator
Theco_3501	COG0457	Tetratricopeptide repeat
Theco_3502	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Theco_3503	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Theco_3504	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Theco_3504	COG0140	phosphoribosyl-ATP diphosphatase activity
Theco_3505	COG0107	imidazoleglycerol-phosphate synthase activity
Theco_3506	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Theco_3507	COG0131	Imidazoleglycerol-phosphate dehydratase
Theco_3508	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Theco_3509	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Theco_3510	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Theco_3512	COG0110	maltose O-acetyltransferase activity
Theco_3513	COG0546	phosphoglycolate phosphatase activity
Theco_3515	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Theco_3516	COG3842	ATPase activity
Theco_3517	COG2508	Transcriptional regulator
Theco_3518	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Theco_3531	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Theco_3532	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Theco_3533	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Theco_3536	COG0254	rRNA binding
Theco_3538	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Theco_3539	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Theco_3540	COG0191	fructose-bisphosphate aldolase activity
Theco_3542	COG0504	CTP synthase activity
Theco_3544	COG3343	RNA polymerase activity
Theco_3545	COG1404	Belongs to the peptidase S8 family
Theco_3546	COG0018	arginyl-trna synthetase
Theco_3552	COG5522	Integral membrane protein (intg_mem_TP0381)
Theco_3555	COG2079	MmgE PrpD family protein
Theco_3556	COG1126	abc transporter atp-binding protein
Theco_3557	COG0765	amino acid transport
Theco_3558	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Theco_3560	COG0010	Belongs to the arginase family
Theco_3561	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Theco_3562	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Theco_3564	COG2409	Drug exporters of the RND superfamily
Theco_3568	COG0791	NLP P60 protein
Theco_3569	COG1201	RNA secondary structure unwinding
Theco_3571	COG1595	DNA-templated transcription, initiation
Theco_3572	COG0726	polysaccharide deacetylase
Theco_3574	COG0737	Belongs to the 5'-nucleotidase family
Theco_3576	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Theco_3579	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Theco_3580	COG0708	Exodeoxyribonuclease III
Theco_3582	COG2211	Major facilitator Superfamily
Theco_3583	COG3842	ATPase activity
Theco_3584	COG1176	ABC-type spermidine putrescine transport system, permease component I
Theco_3586	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Theco_3589	COG0584	glycerophosphoryl diester phosphodiesterase
Theco_3590	COG1175	transmembrane transport
Theco_3592	COG1653	transport
Theco_3593	COG0726	polysaccharide deacetylase
Theco_3600	COG2200	EAL domain
Theco_3602	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Theco_3603	COG1360	Flagellar Motor Protein
Theco_3604	COG4191	Histidine kinase
Theco_3610	COG4974	Belongs to the 'phage' integrase family
Theco_3626	COG0358	DNA primase activity
Theco_3628	COG1595	DNA-templated transcription, initiation
Theco_3630	COG2376	Dihydroxyacetone kinase
Theco_3631	COG1461	Dihydroxyacetone kinase
Theco_3632	COG1609	Transcriptional regulator
Theco_3633	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Theco_3641	COG0577	efflux transmembrane transporter activity
Theco_3641	COG1136	(ABC) transporter
Theco_3642	COG2814	Major facilitator Superfamily
Theco_3645	COG0346	lactoylglutathione lyase activity
Theco_3651	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Theco_3655	COG0516	GMP reductase activity
Theco_3655	COG0517	IMP dehydrogenase activity
Theco_3659	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Theco_3660	COG1396	sequence-specific DNA binding
Theco_3661	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Theco_3662	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Theco_3663	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Theco_3664	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Theco_3665	COG0512	Glutamine amidotransferase of anthranilate synthase
Theco_3666	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Theco_3672	COG3344	reverse transcriptase
Theco_3674	COG0457	Tetratricopeptide repeat
Theco_3675	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Theco_3676	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Theco_3677	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Theco_3678	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Theco_3680	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Theco_3681	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Theco_3682	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Theco_3684	COG0037	tRNA processing
Theco_3685	COG0457	Tetratricopeptide repeat
Theco_3685	COG0515	serine threonine protein kinase
Theco_3686	COG2304	oxidoreductase activity
Theco_3687	COG2208	phosphoserine phosphatase activity
Theco_3690	COG0640	Transcriptional regulator
Theco_3691	COG1098	S1 RNA binding domain
Theco_3695	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Theco_3697	COG3956	TIGRFAM MazG family protein
Theco_3698	COG2002	toxin-antitoxin pair type II binding
Theco_3700	COG0310	cobalt ion transport
Theco_3702	COG0411	ABC transporter
Theco_3704	COG0559	Belongs to the binding-protein-dependent transport system permease family
Theco_3713	COG1454	alcohol dehydrogenase
Theco_3713	COG1012	belongs to the aldehyde dehydrogenase family
Theco_3714	COG0583	DNA-binding transcription factor activity
Theco_3715	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Theco_3716	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Theco_3718	COG0193	aminoacyl-tRNA hydrolase activity
Theco_3720	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Theco_3721	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Theco_3722	COG2088	sporulation resulting in formation of a cellular spore
Theco_3723	COG0251	oxidation-reduction process
Theco_3724	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Theco_3725	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Theco_3727	COG4466	Protein conserved in bacteria
Theco_3729	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Theco_3730	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
Theco_3731	COG3584	3D domain protein
Theco_3731	COG3583	domain protein
Theco_3732	COG0084	hydrolase, TatD family'
Theco_3733	COG1078	dGTPase activity
Theco_3734	COG2002	toxin-antitoxin pair type II binding
Theco_3735	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Theco_3736	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Theco_3738	COG4467	Involved in initiation control of chromosome replication
Theco_3739	COG1774	PSP1 C-terminal conserved region
Theco_3740	COG0470	DNA polymerase III
Theco_3741	COG1728	Protein conserved in bacteria
Theco_3742	COG3870	Protein conserved in bacteria
Theco_3743	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Theco_3744	COG1982	Orn Lys Arg decarboxylase major
Theco_3750	COG3437	response regulator, receiver
Theco_3751	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Theco_3754	COG0187	DNA topoisomerase II activity
Theco_3756	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Theco_3757	COG2501	S4 domain
Theco_3758	COG0592	DNA-directed DNA polymerase activity
Theco_3759	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Theco_3760	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Theco_3761	COG0594	ribonuclease P activity
Theco_3762	COG0706	membrane insertase activity
Theco_3763	COG1847	R3H domain protein
Theco_3764	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Theco_3765	COG0445	tRNA wobble uridine modification
Theco_3766	COG0357	Ribosomal RNA small subunit methyltransferase G
Theco_3767	COG1475	DNA binding
Theco_3768	COG1192	Involved in chromosome partitioning
Theco_3769	COG1475	DNA binding
Theco_3770	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Theco_3774	COG0668	transmembrane transport
Theco_3775	COG4481	Protein conserved in bacteria
Theco_3779	COG0360	Binds together with S18 to 16S ribosomal RNA
Theco_3780	COG0629	single-stranded DNA binding
Theco_3781	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Theco_3782	COG2207	Transcriptional regulator
Theco_3782	COG0662	Cupin 2, conserved barrel domain protein
Theco_3783	COG1064	alcohol dehydrogenase
Theco_3786	COG1316	TRANSCRIPTIONal
Theco_3790	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
Theco_3791	COG0359	binds to the 23S rRNA
Theco_3792	COG0305	Participates in initiation and elongation during chromosome replication
Theco_3793	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Theco_3799	COG0730	response to heat
Theco_3800	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Theco_3800	COG0425	Belongs to the sulfur carrier protein TusA family
Theco_3801	COG0425	Belongs to the sulfur carrier protein TusA family
Theco_3801	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Theco_3802	COG2210	Belongs to the sulfur carrier protein TusA family
Theco_3803	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Theco_3803	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Theco_3804	COG0425	Belongs to the sulfur carrier protein TusA family
Theco_3805	COG2210	Belongs to the sulfur carrier protein TusA family
Theco_3806	COG1937	Protein conserved in bacteria
Theco_3807	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Theco_3814	COG2826	transposase and inactivated derivatives, IS30 family
Theco_3821	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Theco_3827	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Theco_3831	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Theco_3832	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Theco_3834	COG4932	domain protein
Theco_3834	COG5492	domain, Protein
Theco_3839	COG1609	Transcriptional regulator
Theco_3841	COG2385	sporulation resulting in formation of a cellular spore
Theco_3843	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Theco_3846	COG1007	ATP synthesis coupled electron transport
Theco_3847	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Theco_3848	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Theco_3849	COG0713	ATP synthesis coupled electron transport
Theco_3850	COG0839	Belongs to the complex I subunit 6 family
Theco_3852	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Theco_3853	COG0649	NAD binding
Theco_3854	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Theco_3855	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Theco_3856	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Theco_3857	COG1132	(ABC) transporter
Theco_3858	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Theco_3859	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Theco_3860	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Theco_3861	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Theco_3862	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Theco_3863	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Theco_3864	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Theco_3865	COG0356	it plays a direct role in the translocation of protons across the membrane
Theco_3868	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Theco_3869	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Theco_3876	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Theco_3878	COG1459	type II secretion system
Theco_3879	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Theco_3880	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Theco_3882	COG0698	ribose 5-phosphate isomerase
Theco_3884	COG1971	Probably functions as a manganese efflux pump
Theco_3885	COG0009	L-threonylcarbamoyladenylate synthase
Theco_3888	COG2890	protein-(glutamine-N5) methyltransferase activity
Theco_3889	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Theco_3890	COG0012	GTP binding
Theco_3891	COG3118	belongs to the thioredoxin family
Theco_3893	COG0656	L-ascorbic acid biosynthetic process
Theco_3894	COG1801	Protein of unknown function DUF72
Theco_3896	COG2076	Multidrug Resistance protein
Theco_3897	COG2076	Multidrug Resistance protein
Theco_3900	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Theco_3901	COG1215	transferase activity, transferring glycosyl groups
Theco_3902	COG1091	dTDP-4-dehydrorhamnose reductase activity
Theco_3905	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
Theco_3910	COG0463	Glycosyl transferase, family 2
Theco_3913	COG1216	Glycosyl transferase, family 2
Theco_3913	COG0438	transferase activity, transferring glycosyl groups
Theco_3919	COG3693	PFAM glycoside hydrolase, family 10
Theco_3920	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Theco_3921	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Theco_3923	COG0386	Belongs to the glutathione peroxidase family
Theco_3927	COG2814	Major facilitator Superfamily
Theco_3928	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Theco_3929	COG1621	beta-fructofuranosidase activity
Theco_3930	COG2186	Transcriptional regulator
Theco_3931	COG3634	alkyl hydroperoxide reductase activity
Theco_3932	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
Theco_3933	COG1368	sulfuric ester hydrolase activity
Theco_3934	COG0667	Aldo Keto reductase
Theco_3939	COG1033	growth of symbiont in host cell
Theco_3939	COG2409	Drug exporters of the RND superfamily
Theco_3941	COG5002	protein histidine kinase activity
Theco_3943	COG1132	(ABC) transporter
Theco_3944	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Theco_3947	COG0395	ABC-type sugar transport system, permease component
Theco_3948	COG1175	transmembrane transport
Theco_3950	COG1132	(ABC) transporter
Theco_3951	COG1132	(ABC) transporter
Theco_3955	COG1028	Short-chain dehydrogenase reductase Sdr
Theco_3960	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Theco_3962	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
Theco_3963	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Theco_4001	COG0739	heme binding
Theco_4003	COG0433	COG0433 Predicted ATPase
Theco_4036	COG3706	GGDEF domain
Theco_4039	COG3326	Membrane
Theco_4055	COG4974	Belongs to the 'phage' integrase family
Theco_4058	COG2197	response regulator
Theco_4064	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Theco_4070	COG1733	regulation of RNA biosynthetic process
Theco_4071	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Theco_4083	COG1199	ATP-dependent helicase activity
Theco_4107	COG0592	DNA-directed DNA polymerase activity
Theco_4119	COG0629	single-stranded DNA binding