locus-tag	class	description
FOF52_00005	COG1002	Type II restriction enzyme, methylase subunits
FOF52_00010	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FOF52_00065	COG0210	DNA helicase
FOF52_00070	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FOF52_00070	COG0758	DNA mediated transformation
FOF52_00125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOF52_00130	COG1120	ATPase activity
FOF52_00155	COG1132	(ABC) transporter
FOF52_00165	COG2226	methyltransferase
FOF52_00180	COG0583	DNA-binding transcription factor activity
FOF52_00195	COG0604	alcohol dehydrogenase
FOF52_00195	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_00195	COG3321	synthase
FOF52_00230	COG2885	chlorophyll binding
FOF52_00240	COG1012	belongs to the aldehyde dehydrogenase family
FOF52_00265	COG0750	zinc metalloprotease
FOF52_00270	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FOF52_00330	COG0124	histidyl-tRNA synthetase
FOF52_00340	COG0653	protein targeting
FOF52_00370	COG1271	oxidase subunit
FOF52_00375	COG2197	response regulator
FOF52_00380	COG4585	Histidine kinase
FOF52_00400	COG0442	prolyl-tRNA aminoacylation
FOF52_00415	COG0779	Required for maturation of 30S ribosomal subunits
FOF52_00430	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FOF52_00440	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FOF52_00445	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FOF52_00455	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FOF52_00460	COG1185	polyribonucleotide nucleotidyltransferase activity
FOF52_00465	COG0612	Peptidase, M16
FOF52_00470	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FOF52_00475	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FOF52_00490	COG1950	PFAM Membrane protein of
FOF52_00495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FOF52_00500	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FOF52_00505	COG1674	ftsk spoiiie
FOF52_00515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FOF52_00525	COG1546	Belongs to the CinA family
FOF52_00525	COG1058	Belongs to the CinA family
FOF52_00530	COG1396	sequence-specific DNA binding
FOF52_00555	COG1372	Participates in initiation and elongation during chromosome replication
FOF52_00555	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FOF52_00560	COG2137	regulation of response to DNA damage stimulus
FOF52_00565	COG1566	PFAM secretion protein HlyD family protein
FOF52_00565	COG1418	mRNA catabolic process
FOF52_00570	COG1505	serine-type exopeptidase activity
FOF52_00575	COG0765	amino acid transport
FOF52_00580	COG0765	amino acid transport
FOF52_00585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FOF52_00590	COG1126	abc transporter atp-binding protein
FOF52_00595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FOF52_00615	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FOF52_00620	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FOF52_00635	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FOF52_00640	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FOF52_00645	COG1228	amidohydrolase
FOF52_00670	COG1555	photosystem II stabilization
FOF52_00675	COG0268	Binds directly to 16S ribosomal RNA
FOF52_00685	COG0481	GTPase activity
FOF52_00690	COG3833	ABC-type maltose transport systems, permease component
FOF52_00695	COG1175	transmembrane transport
FOF52_00705	COG0366	Alpha amylase catalytic
FOF52_00715	COG2258	MOSC domain
FOF52_00740	COG1420	regulation of RNA biosynthetic process
FOF52_00745	COG0484	heat shock protein binding
FOF52_00770	COG0537	adenosine 5'-monophosphoramidase activity
FOF52_00780	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FOF52_00795	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FOF52_00800	COG1414	Transcriptional regulator
FOF52_00810	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FOF52_00815	COG2340	Cysteine-rich secretory protein family
FOF52_00820	COG1381	Involved in DNA repair and RecF pathway recombination
FOF52_00825	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FOF52_00845	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FOF52_00850	COG1121	(ABC) transporter
FOF52_00865	COG0423	glycine-tRNA ligase activity
FOF52_00875	COG0574	Belongs to the PEP-utilizing enzyme family
FOF52_00875	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FOF52_00885	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FOF52_00890	COG0358	DNA primase activity
FOF52_00895	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FOF52_00935	COG0659	secondary active sulfate transmembrane transporter activity
FOF52_00940	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FOF52_00955	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FOF52_00955	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FOF52_00970	COG1476	TRANSCRIPTIONal
FOF52_01005	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FOF52_01015	COG1846	Transcriptional regulator
FOF52_01020	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FOF52_01045	COG3546	catalase activity
FOF52_01105	COG2192	nodulation
FOF52_01110	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FOF52_01125	COG0438	transferase activity, transferring glycosyl groups
FOF52_01130	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FOF52_01135	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FOF52_01135	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FOF52_01140	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_01145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FOF52_01180	COG3550	peptidyl-serine autophosphorylation
FOF52_01240	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FOF52_01265	COG1349	DNA-binding transcription factor activity
FOF52_01285	COG0601	transmembrane transport
FOF52_01290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FOF52_01295	COG0444	Belongs to the ABC transporter superfamily
FOF52_01325	COG4585	Histidine kinase
FOF52_01330	COG2197	response regulator
FOF52_01355	COG1522	sequence-specific DNA binding
FOF52_01360	COG3483	tryptophan 2,3-dioxygenase activity
FOF52_01395	COG0167	dihydroorotate dehydrogenase activity
FOF52_01425	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FOF52_01430	COG2011	ABC-type metal ion transport system permease component
FOF52_01435	COG1464	Belongs to the NlpA lipoprotein family
FOF52_01450	COG0395	ABC-type sugar transport system, permease component
FOF52_01455	COG2723	6-phospho-beta-galactosidase activity
FOF52_01480	COG2018	Roadblock/LC7 domain
FOF52_01495	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FOF52_01505	COG1960	acyl-CoA dehydrogenase activity
FOF52_01515	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FOF52_01525	COG1252	NADH dehydrogenase
FOF52_01535	COG1937	Protein conserved in bacteria
FOF52_01555	COG0546	phosphoglycolate phosphatase activity
FOF52_01580	COG0686	Belongs to the AlaDH PNT family
FOF52_01585	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FOF52_01595	COG3336	cytochrome c oxidase
FOF52_01660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FOF52_01665	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FOF52_01670	COG0174	glutamine synthetase
FOF52_01675	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FOF52_01675	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FOF52_01690	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FOF52_01715	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FOF52_01720	COG0321	lipoyl(octanoyl) transferase activity
FOF52_01725	COG0508	dehydrogenase complex catalyzes the overall conversion of
FOF52_01730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FOF52_01735	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FOF52_01740	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FOF52_01745	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
FOF52_01755	COG4717	serine-type aminopeptidase activity
FOF52_01760	COG0420	3'-5' exonuclease activity
FOF52_01775	COG0667	Aldo Keto reductase
FOF52_01795	COG0501	Belongs to the peptidase M48B family
FOF52_01805	COG1929	Belongs to the glycerate kinase type-1 family
FOF52_01815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FOF52_01820	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FOF52_01830	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FOF52_01835	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FOF52_01850	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FOF52_01855	COG0723	plastoquinol--plastocyanin reductase activity
FOF52_01860	COG2010	Cytochrome c
FOF52_01865	COG1845	cytochrome c oxidase, subunit III
FOF52_01875	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FOF52_01920	COG1940	carbohydrate kinase activity
FOF52_01945	COG0301	tRNA thio-modification
FOF52_01950	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
FOF52_01955	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FOF52_01960	COG2815	serine threonine protein kinase
FOF52_01960	COG0515	serine threonine protein kinase
FOF52_01965	COG2022	thiamine diphosphate biosynthetic process
FOF52_01975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FOF52_01975	COG2022	thiamine diphosphate biosynthetic process
FOF52_01985	COG0352	thiamine-phosphate diphosphorylase activity
FOF52_02010	COG0142	geranyltranstransferase activity
FOF52_02020	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FOF52_02025	COG0540	Belongs to the ATCase OTCase family
FOF52_02030	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FOF52_02035	COG0505	Belongs to the CarA family
FOF52_02040	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FOF52_02045	COG0543	2 iron, 2 sulfur cluster binding
FOF52_02050	COG0167	dihydroorotate dehydrogenase activity
FOF52_02055	COG0284	orotidine-5'-phosphate decarboxylase activity
FOF52_02065	COG0194	GDP metabolic process
FOF52_02070	COG1758	RNA polymerase activity
FOF52_02080	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FOF52_02095	COG2311	Membrane
FOF52_02115	COG1960	acyl-CoA dehydrogenase activity
FOF52_02120	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FOF52_02140	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FOF52_02155	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FOF52_02165	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FOF52_02175	COG3201	nicotinamide mononucleotide transporter
FOF52_02180	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FOF52_02180	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FOF52_02185	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FOF52_02200	COG2017	converts alpha-aldose to the beta-anomer
FOF52_02205	COG0515	serine threonine protein kinase
FOF52_02205	COG2815	serine threonine protein kinase
FOF52_02220	COG1846	Transcriptional regulator
FOF52_02235	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FOF52_02240	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FOF52_02245	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FOF52_02250	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FOF52_02255	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FOF52_02265	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FOF52_02275	COG1305	Transglutaminase-like
FOF52_02285	COG0714	Associated with various cellular activities
FOF52_02290	COG2001	Belongs to the MraZ family
FOF52_02295	COG0275	rRNA processing
FOF52_02305	COG0768	penicillin binding
FOF52_02310	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FOF52_02320	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FOF52_02325	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FOF52_02335	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FOF52_02340	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FOF52_02350	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FOF52_02355	COG1496	oxidoreductase activity
FOF52_02360	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FOF52_02365	COG1799	cell septum assembly
FOF52_02375	COG3599	regulation of cell shape
FOF52_02385	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FOF52_02395	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FOF52_02445	COG2188	Transcriptional regulator
FOF52_02470	COG2318	DinB family
FOF52_02495	COG2153	protein acetylation
FOF52_02515	COG2814	Major facilitator Superfamily
FOF52_02520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FOF52_02530	COG1132	(ABC) transporter
FOF52_02560	COG1695	Transcriptional regulator
FOF52_02570	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FOF52_02580	COG1528	Iron-storage protein
FOF52_02585	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FOF52_02590	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FOF52_02595	COG0131	Imidazoleglycerol-phosphate dehydratase
FOF52_02605	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FOF52_02610	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FOF52_02615	COG0107	imidazoleglycerol-phosphate synthase activity
FOF52_02625	COG1132	(ABC) transporter
FOF52_02635	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FOF52_02660	COG0134	indole-3-glycerol-phosphate synthase activity
FOF52_02665	COG0133	tryptophan synthase activity
FOF52_02670	COG0159	tryptophan synthase activity
FOF52_02685	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FOF52_02730	COG0693	protein deglycase activity
FOF52_02810	COG0539	negative regulation of cytoplasmic translation
FOF52_02815	COG0237	dephospho-CoA kinase activity
FOF52_02830	COG0556	nucleotide-excision repair
FOF52_02845	COG0504	CTP synthase activity
FOF52_02850	COG0494	nUDIX hydrolase
FOF52_02870	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FOF52_02875	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FOF52_02895	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FOF52_02900	COG1160	GTP binding
FOF52_02915	COG1683	Conserved Protein
FOF52_02930	COG2267	carboxylic ester hydrolase activity
FOF52_02940	COG0318	PFAM AMP-dependent synthetase and ligase
FOF52_02945	COG1960	acyl-CoA dehydrogenase activity
FOF52_02950	COG0318	PFAM AMP-dependent synthetase and ligase
FOF52_02960	COG1309	transcriptional regulator
FOF52_02965	COG0483	inositol monophosphate 1-phosphatase activity
FOF52_03050	COG1609	Transcriptional regulator
FOF52_03075	COG0596	Alpha beta hydrolase
FOF52_03080	COG0583	DNA-binding transcription factor activity
FOF52_03085	COG0477	Major facilitator Superfamily
FOF52_03095	COG3795	YCII-related domain
FOF52_03105	COG4221	oxidoreductase activity
FOF52_03110	COG0667	Aldo Keto reductase
FOF52_03130	COG2197	response regulator
FOF52_03145	COG0477	Major facilitator Superfamily
FOF52_03220	COG4326	sporulation control protein
FOF52_03245	COG1024	Enoyl-CoA hydratase
FOF52_03250	COG0110	maltose O-acetyltransferase activity
FOF52_03265	COG1309	transcriptional regulator
FOF52_03275	COG2226	methyltransferase
FOF52_03300	COG1253	flavin adenine dinucleotide binding
FOF52_03310	COG3622	Belongs to the hyi family
FOF52_03315	COG2084	Dehydrogenase
FOF52_03325	COG3708	Transcriptional regulator
FOF52_03325	COG2207	Transcriptional regulator
FOF52_03335	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FOF52_03405	COG0604	alcohol dehydrogenase
FOF52_03415	COG0183	Belongs to the thiolase family
FOF52_03425	COG1024	Enoyl-CoA hydratase
FOF52_03430	COG1960	acyl-CoA dehydrogenase activity
FOF52_03435	COG1960	acyl-CoA dehydrogenase activity
FOF52_03455	COG2030	dehydratase
FOF52_03460	COG1012	belongs to the aldehyde dehydrogenase family
FOF52_03465	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FOF52_03475	COG0683	leucine binding
FOF52_03480	COG0559	Belongs to the binding-protein-dependent transport system permease family
FOF52_03515	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_03530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FOF52_03550	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FOF52_03555	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FOF52_03575	COG3842	ATPase activity
FOF52_03580	COG1840	ABC-type Fe3 transport system, periplasmic component
FOF52_03590	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FOF52_03590	COG0517	IMP dehydrogenase activity
FOF52_03590	COG0617	tRNA 3'-terminal CCA addition
FOF52_03610	COG0300	oxidoreductase activity
FOF52_03615	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FOF52_03655	COG5002	protein histidine kinase activity
FOF52_03680	COG2267	carboxylic ester hydrolase activity
FOF52_03695	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FOF52_03720	COG1357	PFAM Pentapeptide repeats (8 copies)
FOF52_03725	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FOF52_03730	COG0515	serine threonine protein kinase
FOF52_03730	COG2815	serine threonine protein kinase
FOF52_03745	COG1285	pathogenesis
FOF52_03750	COG3387	PFAM Glycoside hydrolase 15-related
FOF52_03760	COG2267	carboxylic ester hydrolase activity
FOF52_03765	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FOF52_03795	COG0515	serine threonine protein kinase
FOF52_03805	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FOF52_03875	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
FOF52_03945	COG1690	Belongs to the RtcB family
FOF52_04005	COG0746	molybdenum cofactor guanylyltransferase activity
FOF52_04030	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FOF52_04035	COG1316	TRANSCRIPTIONal
FOF52_04045	COG4555	ABC transporter
FOF52_04060	COG2186	Transcriptional regulator
FOF52_04065	COG2807	transmembrane transport
FOF52_04085	COG1960	acyl-CoA dehydrogenase activity
FOF52_04125	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FOF52_04125	COG0512	Glutamine amidotransferase of anthranilate synthase
FOF52_04145	COG1966	Carbon starvation protein
FOF52_04155	COG0003	Pfam Anion-transporting ATPase
FOF52_04160	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FOF52_04170	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FOF52_04190	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FOF52_04190	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FOF52_04205	COG1476	TRANSCRIPTIONal
FOF52_04210	COG1515	deoxyribonuclease V activity
FOF52_04225	COG2197	response regulator
FOF52_04250	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FOF52_04260	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FOF52_04265	COG4948	Mandelate Racemase Muconate Lactonizing
FOF52_04270	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FOF52_04275	COG0589	response to stress
FOF52_04295	COG1649	PFAM Uncharacterised BCR, COG1649
FOF52_04325	COG1289	transmembrane transporter activity
FOF52_04340	COG0583	DNA-binding transcription factor activity
FOF52_04355	COG5006	permease, DMT superfamily
FOF52_04375	COG0598	Magnesium transport protein CorA
FOF52_04460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FOF52_04585	COG2365	Tyrosine phosphatase family
FOF52_04590	COG2271	Major facilitator Superfamily
FOF52_04610	COG1902	pentaerythritol trinitrate reductase activity
FOF52_04630	COG0714	Associated with various cellular activities
FOF52_04640	COG3552	Protein containing von Willebrand factor type A (VWA) domain
FOF52_04660	COG2197	response regulator
FOF52_04675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FOF52_04680	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_04685	COG1169	isochorismate synthase
FOF52_04690	COG1535	isochorismatase
FOF52_04690	COG3433	isochorismatase activity
FOF52_04695	COG1021	2,3-dihydroxybenzoate-AMP ligase
FOF52_04700	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FOF52_04700	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
FOF52_04705	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FOF52_04705	COG3433	isochorismatase activity
FOF52_04705	COG2226	methyltransferase
FOF52_04730	COG1132	(ABC) transporter
FOF52_04730	COG2375	cellular response to nickel ion
FOF52_04745	COG3959	Transketolase, thiamine diphosphate binding domain
FOF52_04750	COG4166	transmembrane transport
FOF52_04755	COG0601	transmembrane transport
FOF52_04760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FOF52_04765	COG4172	Belongs to the ABC transporter superfamily
FOF52_04770	COG3458	cephalosporin-C deacetylase activity
FOF52_04790	COG1012	belongs to the aldehyde dehydrogenase family
FOF52_04815	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_04825	COG1960	acyl-CoA dehydrogenase activity
FOF52_04830	COG2070	2-Nitropropane dioxygenase
FOF52_04855	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_04870	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FOF52_04885	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FOF52_04890	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FOF52_04920	COG0657	acetylesterase activity
FOF52_04925	COG0446	pyridine nucleotide-disulphide oxidoreductase
FOF52_04925	COG1902	pentaerythritol trinitrate reductase activity
FOF52_04935	COG2072	flavoprotein involved in K transport
FOF52_04970	COG1302	Protein conserved in bacteria
FOF52_04995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOF52_05000	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOF52_05005	COG1120	ATPase activity
FOF52_05035	COG0431	NADPH-dependent FMN reductase
FOF52_05040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FOF52_05045	COG0745	RESPONSE REGULATOR receiver
FOF52_05050	COG1414	Transcriptional regulator
FOF52_05060	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FOF52_05065	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FOF52_05070	COG1116	anion transmembrane transporter activity
FOF52_05095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FOF52_05100	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FOF52_05105	COG4521	taurine ABC transporter
FOF52_05115	COG1309	transcriptional regulator
FOF52_05135	COG0596	Alpha beta hydrolase
FOF52_05145	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FOF52_05145	COG2169	Transcriptional regulator
FOF52_05155	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FOF52_05180	COG0789	Transcriptional regulator
FOF52_05185	COG1960	acyl-CoA dehydrogenase activity
FOF52_05190	COG0789	Transcriptional regulator
FOF52_05195	COG2030	dehydratase
FOF52_05205	COG1053	succinate dehydrogenase
FOF52_05215	COG0028	Belongs to the TPP enzyme family
FOF52_05220	COG1053	succinate dehydrogenase
FOF52_05230	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FOF52_05290	COG1024	Enoyl-CoA hydratase
FOF52_05295	COG1250	3-hydroxyacyl-CoA dehydrogenase
FOF52_05305	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_05315	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FOF52_05320	COG1024	Enoyl-CoA hydratase
FOF52_05325	COG1703	isobutyryl-CoA mutase activity
FOF52_05330	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FOF52_05330	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FOF52_05340	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_05355	COG1960	acyl-CoA dehydrogenase activity
FOF52_05360	COG0318	PFAM AMP-dependent synthetase and ligase
FOF52_05365	COG0318	PFAM AMP-dependent synthetase and ligase
FOF52_05370	COG1024	Enoyl-CoA hydratase
FOF52_05405	COG0183	Belongs to the thiolase family
FOF52_05410	COG1024	Enoyl-CoA hydratase
FOF52_05435	COG1053	succinate dehydrogenase
FOF52_05435	COG3976	FMN-binding domain protein
FOF52_05445	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FOF52_05460	COG0515	serine threonine protein kinase
FOF52_05460	COG2815	serine threonine protein kinase
FOF52_05470	COG2233	PERMEase
FOF52_05500	COG0318	PFAM AMP-dependent synthetase and ligase
FOF52_05505	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FOF52_05520	COG1960	acyl-CoA dehydrogenase activity
FOF52_05540	COG1960	acyl-CoA dehydrogenase activity
FOF52_05550	COG1960	acyl-CoA dehydrogenase activity
FOF52_05560	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FOF52_05565	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FOF52_05585	COG0318	PFAM AMP-dependent synthetase and ligase
FOF52_05590	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_05605	COG1024	Enoyl-CoA hydratase
FOF52_05615	COG0318	PFAM AMP-dependent synthetase and ligase
FOF52_05645	COG1024	Enoyl-CoA hydratase
FOF52_05650	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_05655	COG0183	Belongs to the thiolase family
FOF52_05675	COG0492	ferredoxin-NADP+ reductase activity
FOF52_05695	COG0252	asparaginase activity
FOF52_05700	COG1770	oligopeptidase
FOF52_05710	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FOF52_05710	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FOF52_05735	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FOF52_05735	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FOF52_05760	COG1595	DNA-templated transcription, initiation
FOF52_05775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FOF52_05780	COG1234	tRNA 3'-trailer cleavage
FOF52_05785	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FOF52_05790	COG0071	Belongs to the small heat shock protein (HSP20) family
FOF52_05870	COG4974	Belongs to the 'phage' integrase family
FOF52_05895	COG1228	amidohydrolase
FOF52_05910	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FOF52_06000	COG0640	Transcriptional regulator
FOF52_06010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FOF52_06030	COG0583	DNA-binding transcription factor activity
FOF52_06050	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FOF52_06075	COG3189	MarR family transcriptional regulator
FOF52_06115	COG2885	chlorophyll binding
FOF52_06115	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FOF52_06135	COG3629	intracellular signal transduction
FOF52_06135	COG3903	Transcriptional regulator
FOF52_06140	COG2197	response regulator
FOF52_06145	COG4585	Histidine kinase
FOF52_06195	COG2323	membrane
FOF52_06215	COG0798	PFAM Bile acid sodium symporter
FOF52_06225	COG1064	alcohol dehydrogenase
FOF52_06245	COG0574	Belongs to the PEP-utilizing enzyme family
FOF52_06245	COG3848	Pyruvate phosphate dikinase
FOF52_06250	COG0488	(ABC) transporter
FOF52_06270	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FOF52_06325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FOF52_06350	COG4941	Belongs to the sigma-70 factor family
FOF52_06355	COG3795	YCII-related domain
FOF52_06360	COG1960	acyl-CoA dehydrogenase activity
FOF52_06405	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FOF52_06470	COG1131	(ABC) transporter
FOF52_06505	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FOF52_06550	COG0477	Major facilitator Superfamily
FOF52_06570	COG2217	Heavy metal translocating P-type atpase
FOF52_06585	COG0640	Transcriptional regulator
FOF52_06590	COG0346	lactoylglutathione lyase activity
FOF52_06605	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FOF52_06610	COG1518	maintenance of DNA repeat elements
FOF52_06670	COG3467	pyridoxamine 5'-phosphate
FOF52_06680	COG1595	DNA-templated transcription, initiation
FOF52_06685	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FOF52_06705	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FOF52_06705	COG0574	Belongs to the PEP-utilizing enzyme family
FOF52_06745	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_06750	COG0577	efflux transmembrane transporter activity
FOF52_06750	COG1136	(ABC) transporter
FOF52_06760	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_06785	COG1070	Carbohydrate kinase
FOF52_06825	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FOF52_06875	COG1472	Belongs to the glycosyl hydrolase 3 family
FOF52_06880	COG1940	carbohydrate kinase activity
FOF52_06890	COG4209	transmembrane transport
FOF52_06895	COG0395	ABC-type sugar transport system, permease component
FOF52_06905	COG1131	(ABC) transporter
FOF52_06930	COG1136	(ABC) transporter
FOF52_06930	COG0577	efflux transmembrane transporter activity
FOF52_06935	COG0657	acetylesterase activity
FOF52_06950	COG4585	Histidine kinase
FOF52_06955	COG2197	response regulator
FOF52_06970	COG0500	methyltransferase
FOF52_06975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FOF52_06975	COG3321	synthase
FOF52_07015	COG1501	Belongs to the glycosyl hydrolase 31 family
FOF52_07045	COG1175	transmembrane transport
FOF52_07050	COG1653	transport
FOF52_07060	COG1396	sequence-specific DNA binding
FOF52_07070	COG0726	polysaccharide deacetylase
FOF52_07075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FOF52_07090	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FOF52_07105	COG5006	permease, DMT superfamily
FOF52_07120	COG2855	membrane
FOF52_07150	COG0601	transmembrane transport
FOF52_07155	COG4166	transmembrane transport
FOF52_07175	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FOF52_07185	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_07215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FOF52_07265	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_07270	COG2323	membrane
FOF52_07280	COG1090	epimerase
FOF52_07290	COG2267	carboxylic ester hydrolase activity
FOF52_07300	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_07335	COG2815	serine threonine protein kinase
FOF52_07335	COG0515	serine threonine protein kinase
FOF52_07350	COG4221	oxidoreductase activity
FOF52_07365	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FOF52_07370	COG0243	molybdopterin cofactor binding
FOF52_07390	COG3629	intracellular signal transduction
FOF52_07390	COG3903	Transcriptional regulator
FOF52_07415	COG1819	glycosyl
FOF52_07420	COG2124	cytochrome p450
FOF52_07425	COG0702	epimerase
FOF52_07470	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
FOF52_07480	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FOF52_07500	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
FOF52_07525	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FOF52_07540	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FOF52_07545	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FOF52_07570	COG1819	glycosyl
FOF52_07610	COG0579	oxidoreductase
FOF52_07630	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FOF52_07635	COG1121	(ABC) transporter
FOF52_07655	COG0512	Glutamine amidotransferase of anthranilate synthase
FOF52_07655	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FOF52_07660	COG0789	Transcriptional regulator
FOF52_07665	COG0659	secondary active sulfate transmembrane transporter activity
FOF52_07670	COG0477	Major facilitator Superfamily
FOF52_07675	COG1252	NADH dehydrogenase
FOF52_07680	COG1595	DNA-templated transcription, initiation
FOF52_07700	COG2226	methyltransferase
FOF52_07705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FOF52_07710	COG4106	trans-aconitate 2-methyltransferase activity
FOF52_07720	COG3540	Alkaline phosphatase
FOF52_07725	COG0667	Aldo Keto reductase
FOF52_07735	COG0714	Associated with various cellular activities
FOF52_07745	COG2304	oxidoreductase activity
FOF52_07750	COG0546	phosphoglycolate phosphatase activity
FOF52_07755	COG1051	belongs to the nudix hydrolase family
FOF52_07765	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_07770	COG2813	Specifically methylates the guanine in position
FOF52_07775	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FOF52_07780	COG1253	flavin adenine dinucleotide binding
FOF52_07785	COG1253	flavin adenine dinucleotide binding
FOF52_07800	COG1012	belongs to the aldehyde dehydrogenase family
FOF52_07825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FOF52_07830	COG0730	response to heat
FOF52_07835	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FOF52_07840	COG0028	Belongs to the TPP enzyme family
FOF52_07880	COG1132	(ABC) transporter
FOF52_07890	COG2072	flavoprotein involved in K transport
FOF52_07900	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_07905	COG2755	lipolytic protein G-D-S-L family
FOF52_07905	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FOF52_07910	COG1653	transport
FOF52_07915	COG0395	ABC-type sugar transport system, permease component
FOF52_07920	COG1175	transmembrane transport
FOF52_07925	COG0673	inositol 2-dehydrogenase activity
FOF52_07960	COG2188	Transcriptional regulator
FOF52_07980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FOF52_07985	COG2376	Dihydroxyacetone kinase
FOF52_07995	COG0723	plastoquinol--plastocyanin reductase activity
FOF52_07995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FOF52_08000	COG4948	Mandelate Racemase Muconate Lactonizing
FOF52_08005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FOF52_08020	COG0673	inositol 2-dehydrogenase activity
FOF52_08035	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FOF52_08060	COG0789	Transcriptional regulator
FOF52_08085	COG0242	peptide deformylase activity
FOF52_08095	COG2814	Major facilitator Superfamily
FOF52_08100	COG0463	Glycosyl transferase, family 2
FOF52_08110	COG0463	Glycosyl transferase, family 2
FOF52_08120	COG1022	Amp-dependent synthetase and ligase
FOF52_08130	COG2814	Major facilitator Superfamily
FOF52_08150	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FOF52_08165	COG1278	Cold shock
FOF52_08180	COG0583	DNA-binding transcription factor activity
FOF52_08185	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FOF52_08190	COG1216	Glycosyl transferase, family 2
FOF52_08190	COG1442	glycosyl transferase family 8
FOF52_08200	COG0006	proline dipeptidase activity
FOF52_08235	COG2124	cytochrome p450
FOF52_08265	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FOF52_08275	COG1120	ATPase activity
FOF52_08280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOF52_08295	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
FOF52_08300	COG2226	methyltransferase
FOF52_08310	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FOF52_08325	COG2378	regulation of single-species biofilm formation
FOF52_08330	COG3739	integral membrane protein
FOF52_08355	COG2124	cytochrome p450
FOF52_08370	COG3655	Transcriptional regulator
FOF52_08415	COG0438	transferase activity, transferring glycosyl groups
FOF52_08420	COG0366	Alpha amylase catalytic
FOF52_08425	COG2197	response regulator
FOF52_08430	COG4585	Histidine kinase
FOF52_08445	COG4581	dead DEAH box helicase
FOF52_08460	COG0805	protein transport
FOF52_08500	COG1960	acyl-CoA dehydrogenase activity
FOF52_08540	COG2186	Transcriptional regulator
FOF52_08545	COG4948	Mandelate Racemase Muconate Lactonizing
FOF52_08555	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
FOF52_08560	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
FOF52_08565	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
FOF52_08585	COG0477	Major facilitator Superfamily
FOF52_08595	COG4122	O-methyltransferase activity
FOF52_08605	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FOF52_08615	COG1222	aaa ATPase
FOF52_08645	COG0517	IMP dehydrogenase activity
FOF52_08645	COG1994	Peptidase M50
FOF52_08655	COG2197	response regulator
FOF52_08695	COG0646	methionine synthase
FOF52_08695	COG1410	methionine synthase
FOF52_08720	COG0215	cysteine-tRNA ligase activity
FOF52_08735	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FOF52_08750	COG0406	alpha-ribazole phosphatase activity
FOF52_08755	COG1968	undecaprenyl-diphosphatase activity
FOF52_08760	COG0667	Aldo Keto reductase
FOF52_08775	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_08785	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_08795	COG3173	Aminoglycoside phosphotransferase
FOF52_08810	COG2197	response regulator
FOF52_08815	COG4585	Histidine kinase
FOF52_08820	COG1136	(ABC) transporter
FOF52_08820	COG0577	efflux transmembrane transporter activity
FOF52_08825	COG0577	efflux transmembrane transporter activity
FOF52_08825	COG1136	(ABC) transporter
FOF52_08860	COG1349	DNA-binding transcription factor activity
FOF52_08865	COG2091	lysine biosynthetic process via aminoadipic acid
FOF52_08870	COG1505	serine-type exopeptidase activity
FOF52_08920	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FOF52_08930	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FOF52_08935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FOF52_08950	COG1535	isochorismatase
FOF52_08950	COG3433	isochorismatase activity
FOF52_08965	COG1021	2,3-dihydroxybenzoate-AMP ligase
FOF52_08970	COG1169	isochorismate synthase
FOF52_08975	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_08985	COG0701	Predicted permease
FOF52_08990	COG2130	NADP-dependent
FOF52_09000	COG1733	regulation of RNA biosynthetic process
FOF52_09025	COG0488	(ABC) transporter
FOF52_09070	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FOF52_09080	COG0175	sulfate reduction
FOF52_09090	COG1309	transcriptional regulator
FOF52_09100	COG1960	acyl-CoA dehydrogenase activity
FOF52_09115	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FOF52_09120	COG0688	phosphatidylethanolamine metabolic process
FOF52_09130	COG3253	May function as heme-dependent peroxidase
FOF52_09135	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
FOF52_09145	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FOF52_09165	COG0183	Belongs to the thiolase family
FOF52_09190	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FOF52_09200	COG2409	Drug exporters of the RND superfamily
FOF52_09220	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
FOF52_09235	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FOF52_09240	COG3663	DNA glycosylase
FOF52_09250	COG4214	carbohydrate transport
FOF52_09260	COG4213	ABC transporter substrate-binding protein
FOF52_09265	COG1940	carbohydrate kinase activity
FOF52_09290	COG4607	ABC-type enterochelin transport system periplasmic component
FOF52_09295	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOF52_09300	COG4605	iron ion homeostasis
FOF52_09305	COG4604	ABC transporter, ATP-binding protein
FOF52_09320	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FOF52_09325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FOF52_09330	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FOF52_09335	COG0569	domain protein
FOF52_09345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FOF52_09375	COG0756	dUTP diphosphatase activity
FOF52_09380	COG0525	valine-tRNA ligase activity
FOF52_09400	COG2205	protein histidine kinase activity
FOF52_09405	COG0745	RESPONSE REGULATOR receiver
FOF52_09425	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FOF52_09480	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FOF52_09490	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FOF52_09505	COG4733	cellulase activity
FOF52_09505	COG5297	Belongs to the glycosyl hydrolase family 6
FOF52_09515	COG0009	L-threonylcarbamoyladenylate synthase
FOF52_09525	COG2318	DinB family
FOF52_09530	COG2813	Specifically methylates the guanine in position
FOF52_09535	COG1396	sequence-specific DNA binding
FOF52_09575	COG0432	Pfam Uncharacterised protein family UPF0047
FOF52_09585	COG1984	allophanate hydrolase subunit 2
FOF52_09590	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FOF52_09595	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FOF52_09615	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FOF52_09620	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FOF52_09625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FOF52_09635	COG2755	lipolytic protein G-D-S-L family
FOF52_09650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FOF52_09660	COG2151	metal-sulfur cluster biosynthetic enzyme
FOF52_09675	COG0396	ATPase activity
FOF52_09700	COG1131	(ABC) transporter
FOF52_09720	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FOF52_09725	COG2235	arginine
FOF52_09740	COG3311	Transcriptional regulator
FOF52_09760	COG0318	PFAM AMP-dependent synthetase and ligase
FOF52_09765	COG1960	acyl-CoA dehydrogenase activity
FOF52_09780	COG0109	protoheme IX farnesyltransferase activity
FOF52_09790	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FOF52_09795	COG0166	Belongs to the GPI family
FOF52_09810	COG0363	glucosamine-6-phosphate deaminase activity
FOF52_09820	COG3401	FG-GAP repeat protein
FOF52_09835	COG0531	amino acid
FOF52_09850	COG0400	carboxylic ester hydrolase activity
FOF52_09855	COG0346	lactoylglutathione lyase activity
FOF52_09865	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FOF52_09870	COG0149	triose-phosphate isomerase activity
FOF52_09875	COG0126	phosphoglycerate kinase activity
FOF52_09880	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FOF52_09885	COG1481	regulation of sporulation
FOF52_09895	COG1660	Displays ATPase and GTPase activities
FOF52_09900	COG0322	excinuclease ABC activity
FOF52_09920	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FOF52_09955	COG0497	DNA recombination
FOF52_09960	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FOF52_09990	COG0647	UMP catabolic process
FOF52_10035	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FOF52_10085	COG2205	protein histidine kinase activity
FOF52_10090	COG0165	Argininosuccinate lyase
FOF52_10095	COG0137	argininosuccinate synthase activity
FOF52_10100	COG1438	arginine binding
FOF52_10105	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FOF52_10110	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FOF52_10115	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FOF52_10120	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FOF52_10125	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
FOF52_10130	COG1846	Transcriptional regulator
FOF52_10140	COG0745	RESPONSE REGULATOR receiver
FOF52_10145	COG2205	protein histidine kinase activity
FOF52_10155	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FOF52_10155	COG0072	phenylalanine-tRNA ligase activity
FOF52_10160	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FOF52_10165	COG5002	protein histidine kinase activity
FOF52_10170	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FOF52_10175	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FOF52_10180	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FOF52_10185	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FOF52_10190	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FOF52_10200	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FOF52_10205	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FOF52_10210	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FOF52_10215	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FOF52_10265	COG0515	serine threonine protein kinase
FOF52_10265	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FOF52_10320	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FOF52_10330	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FOF52_10340	COG1196	nuclear chromosome segregation
FOF52_10350	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FOF52_10355	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FOF52_10360	COG1862	Preprotein translocase
FOF52_10365	COG2255	four-way junction helicase activity
FOF52_10370	COG0632	four-way junction helicase activity
FOF52_10375	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FOF52_10380	COG0217	transcriptional regulatory protein
FOF52_10385	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
FOF52_10390	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
FOF52_10400	COG0438	transferase activity, transferring glycosyl groups
FOF52_10405	COG1560	Kdo2-lipid A biosynthetic process
FOF52_10410	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FOF52_10425	COG1253	flavin adenine dinucleotide binding
FOF52_10435	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FOF52_10490	COG3265	gluconokinase activity
FOF52_10520	COG1011	Hydrolase
FOF52_10560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FOF52_10575	COG0045	succinate-CoA ligase (ADP-forming) activity
FOF52_10585	COG0514	ATP-dependent DNA helicase (RecQ)
FOF52_10595	COG1320	monovalent cation:proton antiporter activity
FOF52_10600	COG2212	antiporter activity
FOF52_10610	COG0651	ATP synthesis coupled electron transport
FOF52_10615	COG1006	Multisubunit Na H antiporter MnhC subunit
FOF52_10620	COG2111	Na H antiporter
FOF52_10625	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FOF52_10625	COG2111	Na H antiporter
FOF52_10630	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FOF52_10645	COG0187	DNA topoisomerase II activity
FOF52_10660	COG3022	response to hydroperoxide
FOF52_10675	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FOF52_10700	COG0464	growth
FOF52_10705	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FOF52_10730	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FOF52_10735	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FOF52_10740	COG1388	LysM domain
FOF52_10745	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FOF52_10765	COG0495	leucyl-tRNA aminoacylation
FOF52_10775	COG0318	PFAM AMP-dependent synthetase and ligase
FOF52_10780	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
FOF52_10795	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FOF52_10805	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FOF52_10865	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FOF52_10870	COG0501	Belongs to the peptidase M48B family
FOF52_10890	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FOF52_10900	COG0438	transferase activity, transferring glycosyl groups
FOF52_10905	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FOF52_10910	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FOF52_10915	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FOF52_10920	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FOF52_10925	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FOF52_10930	COG1530	ribonuclease E activity
FOF52_10945	COG0772	Belongs to the SEDS family
FOF52_10955	COG0105	UTP biosynthetic process
FOF52_10965	COG0285	dihydrofolate synthase activity
FOF52_10975	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FOF52_10980	COG0740	serine-type endopeptidase activity
FOF52_10985	COG0740	serine-type endopeptidase activity
FOF52_10990	COG0544	peptidyl-prolyl cis-trans isomerase activity
FOF52_11005	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FOF52_11005	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FOF52_11010	COG1132	(ABC) transporter
FOF52_11020	COG2239	Acts as a magnesium transporter
FOF52_11030	COG4552	Acetyltransferase involved in intracellular survival and related
FOF52_11035	COG0698	ribose 5-phosphate isomerase
FOF52_11050	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FOF52_11080	COG0129	dihydroxy-acid dehydratase activity
FOF52_11095	COG1505	serine-type exopeptidase activity
FOF52_11105	COG2271	Major facilitator Superfamily
FOF52_11130	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FOF52_11140	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FOF52_11140	COG1648	precorrin-2 dehydrogenase activity
FOF52_11145	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FOF52_11170	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FOF52_11170	COG0515	serine threonine protein kinase
FOF52_11195	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
FOF52_11215	COG4585	Histidine kinase
FOF52_11220	COG2197	response regulator
FOF52_11225	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FOF52_11230	COG3766	membrane
FOF52_11255	COG1522	sequence-specific DNA binding
FOF52_11280	COG0477	Major facilitator Superfamily
FOF52_11290	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FOF52_11295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FOF52_11310	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FOF52_11335	COG1115	amino acid carrier protein
FOF52_11350	COG0436	Aminotransferase
FOF52_11355	COG0583	DNA-binding transcription factor activity
FOF52_11370	COG0438	transferase activity, transferring glycosyl groups
FOF52_11405	COG1597	lipid kinase activity
FOF52_11435	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FOF52_11455	COG2894	cell division
FOF52_11480	COG4585	Histidine kinase
FOF52_11485	COG2197	response regulator
FOF52_11510	COG0741	lytic transglycosylase activity
FOF52_11510	COG0791	NLP P60 protein
FOF52_11545	COG0667	Aldo Keto reductase
FOF52_11565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FOF52_11590	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FOF52_11595	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FOF52_11600	COG0569	domain protein
FOF52_11630	COG1960	acyl-CoA dehydrogenase activity
FOF52_11635	COG1960	acyl-CoA dehydrogenase activity
FOF52_11645	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FOF52_11650	COG1122	ATPase activity
FOF52_11655	COG1268	BioY protein
FOF52_11660	COG2706	6-phosphogluconolactonase activity
FOF52_11680	COG2018	Roadblock/LC7 domain
FOF52_11690	COG1643	Atp-dependent helicase
FOF52_11745	COG1737	Transcriptional regulator
FOF52_11750	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FOF52_11755	COG2949	membrane
FOF52_11795	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FOF52_11860	COG3395	kinase activity
FOF52_11865	COG0673	inositol 2-dehydrogenase activity
FOF52_11870	COG1653	transport
FOF52_11875	COG1175	transmembrane transport
FOF52_11880	COG0395	ABC-type sugar transport system, permease component
FOF52_11890	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FOF52_11895	COG0784	Response regulator, receiver
FOF52_11900	COG4251	negative regulation of phosphorylation
FOF52_11910	COG5398	heme oxygenase
FOF52_11925	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FOF52_11935	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FOF52_11940	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FOF52_11945	COG0509	glycine decarboxylation via glycine cleavage system
FOF52_11950	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FOF52_11990	COG0515	serine threonine protein kinase
FOF52_11990	COG2815	serine threonine protein kinase
FOF52_12000	COG1025	Belongs to the peptidase M16 family
FOF52_12020	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FOF52_12025	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FOF52_12060	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FOF52_12070	COG1335	isochorismatase
FOF52_12085	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FOF52_12085	COG0515	serine threonine protein kinase
FOF52_12125	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FOF52_12130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOF52_12150	COG1678	Uncharacterized ACR, COG1678
FOF52_12175	COG0183	Belongs to the thiolase family
FOF52_12200	COG1250	3-hydroxyacyl-CoA dehydrogenase
FOF52_12210	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
FOF52_12245	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FOF52_12250	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FOF52_12255	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FOF52_12260	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FOF52_12265	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FOF52_12270	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FOF52_12275	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FOF52_12295	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FOF52_12305	COG2890	protein-(glutamine-N5) methyltransferase activity
FOF52_12310	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FOF52_12315	COG0254	rRNA binding
FOF52_12325	COG0083	homoserine kinase activity
FOF52_12330	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FOF52_12335	COG0460	homoserine dehydrogenase
FOF52_12340	COG0019	diaminopimelate decarboxylase activity
FOF52_12350	COG0745	RESPONSE REGULATOR receiver
FOF52_12360	COG2272	Belongs to the type-B carboxylesterase lipase family
FOF52_12390	COG0242	peptide deformylase activity
FOF52_12420	COG3594	Acyltransferase
FOF52_12480	COG1061	Type III restriction enzyme res subunit
FOF52_12485	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FOF52_12490	COG1053	succinate dehydrogenase
FOF52_12505	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FOF52_12510	COG1217	gtp-binding protein TYPA
FOF52_12515	COG0494	nUDIX hydrolase
FOF52_12550	COG2226	methyltransferase
FOF52_12555	COG0500	methyltransferase
FOF52_12565	COG4981	capsule polysaccharide biosynthetic process
FOF52_12625	COG0438	transferase activity, transferring glycosyl groups
FOF52_12655	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FOF52_12660	COG2177	Part of the ABC transporter FtsEX involved in
FOF52_12665	COG2884	Cell division ATP-binding protein ftsE
FOF52_12670	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FOF52_12680	COG2902	Dehydrogenase
FOF52_12700	COG1011	Hydrolase
FOF52_12705	COG1960	acyl-CoA dehydrogenase activity
FOF52_12710	COG1472	Belongs to the glycosyl hydrolase 3 family
FOF52_12715	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FOF52_12730	COG0653	protein targeting
FOF52_12735	COG2197	response regulator
FOF52_12740	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FOF52_12750	COG5401	PFAM Sporulation and spore germination
FOF52_12755	COG5002	protein histidine kinase activity
FOF52_12755	COG5000	phosphorelay sensor kinase activity
FOF52_12760	COG0745	RESPONSE REGULATOR receiver
FOF52_12780	COG0714	Associated with various cellular activities
FOF52_12805	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FOF52_12825	COG2835	tetraacyldisaccharide 4'-kinase activity
FOF52_12865	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FOF52_12870	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
FOF52_12870	COG0778	Nitroreductase
FOF52_12875	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
FOF52_12880	COG2226	methyltransferase
FOF52_12910	COG1316	TRANSCRIPTIONal
FOF52_12930	COG0778	Nitroreductase
FOF52_12965	COG1134	teichoic acid transport
FOF52_12975	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FOF52_12990	COG1316	TRANSCRIPTIONal
FOF52_13000	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FOF52_13005	COG1832	CoA-binding protein
FOF52_13030	COG0745	RESPONSE REGULATOR receiver
FOF52_13035	COG5002	protein histidine kinase activity
FOF52_13045	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
FOF52_13055	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FOF52_13060	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FOF52_13070	COG4770	biotin carboxylase activity
FOF52_13130	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FOF52_13135	COG1473	amidohydrolase
FOF52_13135	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
FOF52_13140	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
FOF52_13150	COG1316	TRANSCRIPTIONal
FOF52_13170	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FOF52_13175	COG0138	bifunctional purine biosynthesis protein purh
FOF52_13180	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FOF52_13200	COG0045	succinate-CoA ligase (ADP-forming) activity
FOF52_13235	COG1957	nucleoside hydrolase
FOF52_13240	COG2197	response regulator
FOF52_13245	COG4585	Histidine kinase
FOF52_13280	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FOF52_13280	COG0519	Catalyzes the synthesis of GMP from XMP
FOF52_13285	COG1012	belongs to the aldehyde dehydrogenase family
FOF52_13300	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FOF52_13310	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FOF52_13315	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FOF52_13325	COG0516	GMP reductase activity
FOF52_13335	COG1595	DNA-templated transcription, initiation
FOF52_13340	COG0459	protein refolding
FOF52_13345	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FOF52_13370	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FOF52_13375	COG1247	-acetyltransferase
FOF52_13385	COG0802	atpase or kinase
FOF52_13390	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FOF52_13415	COG1072	(Pantothenic acid kinase))
FOF52_13425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FOF52_13435	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FOF52_13440	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FOF52_13445	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FOF52_13455	COG0101	tRNA pseudouridine synthase activity
FOF52_13460	COG0203	ribosomal protein L17
FOF52_13465	COG0202	RNA polymerase activity
FOF52_13470	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FOF52_13475	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FOF52_13480	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FOF52_13485	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FOF52_13495	COG0024	Methionine aminopeptidase
FOF52_13500	COG0563	adenylate kinase activity
FOF52_13510	COG0200	Binds to the 23S rRNA
FOF52_13515	COG1841	ribosomal large subunit assembly
FOF52_13520	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FOF52_13525	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FOF52_13530	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FOF52_13535	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FOF52_13540	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FOF52_13545	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FOF52_13550	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FOF52_13555	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FOF52_13560	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FOF52_13565	COG0255	Belongs to the universal ribosomal protein uL29 family
FOF52_13570	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FOF52_13575	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FOF52_13580	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FOF52_13585	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FOF52_13590	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FOF52_13595	COG0089	rRNA binding
FOF52_13600	COG0088	Forms part of the polypeptide exit tunnel
FOF52_13605	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FOF52_13610	COG0051	transcription antitermination factor activity, RNA binding
FOF52_13615	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FOF52_13620	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FOF52_13625	COG0049	tRNA binding
FOF52_13630	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FOF52_13640	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FOF52_13645	COG0085	RNA polymerase activity
FOF52_13650	COG0222	ribosome binding
FOF52_13655	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FOF52_13665	COG0081	regulation of translation
FOF52_13670	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FOF52_13680	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FOF52_13690	COG0436	Aminotransferase
FOF52_13695	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FOF52_13700	COG2119	membrane
FOF52_13705	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FOF52_13715	COG2030	dehydratase
FOF52_13720	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FOF52_13735	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FOF52_13765	COG1666	GTP binding
FOF52_13770	COG0501	Belongs to the peptidase M48B family
FOF52_13775	COG0674	pyruvate-flavodoxin oxidoreductase activity
FOF52_13775	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FOF52_13780	COG1013	pyruvate-flavodoxin oxidoreductase activity
FOF52_13785	COG0702	epimerase
FOF52_13795	COG0456	acetyltransferase
FOF52_13815	COG1595	DNA-templated transcription, initiation
FOF52_13825	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FOF52_13835	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
FOF52_13840	COG0142	geranyltranstransferase activity
FOF52_13845	COG1007	ATP synthesis coupled electron transport
FOF52_13860	COG0713	ATP synthesis coupled electron transport
FOF52_13870	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FOF52_13875	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FOF52_13880	COG1034	ATP synthesis coupled electron transport
FOF52_13885	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FOF52_13895	COG0649	NAD binding
FOF52_13900	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FOF52_13905	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FOF52_13920	COG2226	methyltransferase
FOF52_13940	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FOF52_13950	COG0785	Cytochrome C biogenesis protein
FOF52_13955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FOF52_13970	COG0123	including yeast histone deacetylase and acetoin utilization protein
FOF52_13975	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FOF52_13985	COG1082	Xylose isomerase domain protein TIM barrel
FOF52_13995	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FOF52_14010	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FOF52_14030	COG2897	thiosulfate sulfurtransferase activity
FOF52_14060	COG0406	alpha-ribazole phosphatase activity
FOF52_14065	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FOF52_14070	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FOF52_14085	COG0113	porphobilinogen synthase activity
FOF52_14095	COG0181	hydroxymethylbilane synthase activity
FOF52_14100	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FOF52_14105	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
FOF52_14120	COG0745	RESPONSE REGULATOR receiver
FOF52_14130	COG0456	acetyltransferase
FOF52_14150	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FOF52_14165	COG0306	phosphate transporter
FOF52_14170	COG1392	Phosphate transport regulator
FOF52_14185	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FOF52_14210	COG0860	N-Acetylmuramoyl-L-alanine amidase
FOF52_14220	COG1309	transcriptional regulator
FOF52_14230	COG1739	Uncharacterized protein family UPF0029
FOF52_14240	COG0386	Belongs to the glutathione peroxidase family
FOF52_14270	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FOF52_14295	COG1486	melibiose metabolic process
FOF52_14340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FOF52_14390	COG2188	Transcriptional regulator
FOF52_14430	COG1774	PSP1 C-terminal conserved region
FOF52_14435	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FOF52_14440	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FOF52_14445	COG1754	DNA topoisomerase type I activity
FOF52_14445	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FOF52_14460	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FOF52_14480	COG1609	Transcriptional regulator
FOF52_14490	COG3903	Transcriptional regulator
FOF52_14490	COG3629	intracellular signal transduction
FOF52_14510	COG0714	Associated with various cellular activities
FOF52_14600	COG0681	Belongs to the peptidase S26 family
FOF52_14605	COG1132	(ABC) transporter
FOF52_14690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FOF52_14695	COG2508	Transcriptional regulator
FOF52_14695	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
FOF52_14725	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FOF52_14730	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FOF52_14735	COG0142	geranyltranstransferase activity
FOF52_14740	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FOF52_14755	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_14810	COG0477	Major facilitator Superfamily
FOF52_14850	COG5285	phytanoyl-CoA dioxygenase
FOF52_14855	COG2814	Major facilitator Superfamily
FOF52_14860	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_14875	COG1024	Enoyl-CoA hydratase
FOF52_14885	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FOF52_14890	COG1024	Enoyl-CoA hydratase
FOF52_14890	COG1250	3-hydroxyacyl-CoA dehydrogenase
FOF52_14900	COG4770	biotin carboxylase activity
FOF52_14905	COG0183	Belongs to the thiolase family
FOF52_14915	COG1137	ATPase activity
FOF52_14925	COG0559	Belongs to the binding-protein-dependent transport system permease family
FOF52_14950	COG1960	acyl-CoA dehydrogenase activity
FOF52_14955	COG0318	PFAM AMP-dependent synthetase and ligase
FOF52_14980	COG3119	arylsulfatase activity
FOF52_15020	COG2205	protein histidine kinase activity
FOF52_15030	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FOF52_15035	COG2197	response regulator
FOF52_15045	COG1703	isobutyryl-CoA mutase activity
FOF52_15045	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FOF52_15045	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FOF52_15055	COG1063	alcohol dehydrogenase
FOF52_15075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FOF52_15080	COG4260	virion core protein, lumpy skin disease virus
FOF52_15105	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FOF52_15110	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FOF52_15125	COG2197	response regulator
FOF52_15135	COG1136	(ABC) transporter
FOF52_15210	COG1309	transcriptional regulator
FOF52_15215	COG2814	Major facilitator Superfamily
FOF52_15220	COG0477	Major facilitator Superfamily
FOF52_15240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FOF52_15245	COG0247	lactate metabolic process
FOF52_15245	COG0277	FAD linked oxidase domain protein
FOF52_15255	COG0515	serine threonine protein kinase
FOF52_15335	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_15340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FOF52_15345	COG3275	phosphorelay sensor kinase activity
FOF52_15350	COG3279	Response regulator of the LytR AlgR family
FOF52_15360	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FOF52_15370	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FOF52_15400	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FOF52_15455	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FOF52_15465	COG0494	nUDIX hydrolase
FOF52_15485	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FOF52_15500	COG3226	Transcriptional regulator
FOF52_15505	COG0738	Major facilitator superfamily
FOF52_15515	COG2226	methyltransferase
FOF52_15555	COG3485	protocatechuate 3,4-dioxygenase
FOF52_15560	COG0354	folic acid binding
FOF52_15600	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FOF52_15610	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FOF52_15615	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FOF52_15620	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FOF52_15625	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FOF52_15655	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FOF52_15660	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FOF52_15670	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FOF52_15675	COG0302	gtp cyclohydrolase
FOF52_15685	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
FOF52_15690	COG0037	tRNA processing
FOF52_15715	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FOF52_15720	COG2027	D-alanyl-D-alanine carboxypeptidase
FOF52_15735	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FOF52_15740	COG1329	Transcriptional regulator
FOF52_15750	COG5002	protein histidine kinase activity
FOF52_15760	COG0588	phosphoglycerate mutase activity
FOF52_15770	COG0438	transferase activity, transferring glycosyl groups
FOF52_15790	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FOF52_15850	COG1490	D-aminoacyl-tRNA deacylase activity
FOF52_15890	COG2113	Glycine betaine
FOF52_15895	COG4176	ABC-type proline glycine betaine transport system permease component
FOF52_15900	COG3448	diguanylate cyclase activity
FOF52_15900	COG4175	Glycine betaine
FOF52_15910	COG0717	Belongs to the dCTP deaminase family
FOF52_15980	COG0435	Glutathione S-transferase
FOF52_15990	COG0702	epimerase
FOF52_15995	COG2409	Drug exporters of the RND superfamily
FOF52_16005	COG0596	Alpha beta hydrolase
FOF52_16005	COG0508	dehydrogenase complex catalyzes the overall conversion of
FOF52_16020	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FOF52_16025	COG2197	response regulator
FOF52_16030	COG4585	Histidine kinase
FOF52_16045	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FOF52_16050	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FOF52_16050	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FOF52_16080	COG1324	tolerance protein
FOF52_16085	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FOF52_16105	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FOF52_16110	COG0151	Belongs to the GarS family
FOF52_16115	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FOF52_16120	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FOF52_16125	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FOF52_16135	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FOF52_16155	COG1595	DNA-templated transcription, initiation
FOF52_16165	COG2124	cytochrome p450
FOF52_16170	COG2124	cytochrome p450
FOF52_16210	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FOF52_16220	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_16290	COG2197	response regulator
FOF52_16305	COG1316	TRANSCRIPTIONal
FOF52_16320	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FOF52_16345	COG0582	viral genome integration into host DNA
FOF52_16370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FOF52_16380	COG1609	Transcriptional regulator
FOF52_16390	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FOF52_16395	COG3795	YCII-related domain
FOF52_16400	COG4941	Belongs to the sigma-70 factor family
FOF52_16410	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FOF52_16480	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FOF52_16485	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FOF52_16495	COG0589	response to stress
FOF52_16585	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FOF52_16590	COG0022	dehydrogenase e1 component
FOF52_16590	COG0508	dehydrogenase complex catalyzes the overall conversion of
FOF52_16595	COG0508	dehydrogenase complex catalyzes the overall conversion of
FOF52_16610	COG1215	transferase activity, transferring glycosyl groups
FOF52_16615	COG1366	Belongs to the anti-sigma-factor antagonist family
FOF52_16625	COG5002	protein histidine kinase activity
FOF52_16630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FOF52_16650	COG1716	ATPase activity
FOF52_16665	COG0768	penicillin binding
FOF52_16670	COG0515	serine threonine protein kinase
FOF52_16675	COG0515	serine threonine protein kinase
FOF52_16685	COG0705	Rhomboid family
FOF52_16735	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
FOF52_16755	COG2837	iron assimilation
FOF52_16785	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FOF52_16795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FOF52_16825	COG2226	methyltransferase
FOF52_16845	COG0359	binds to the 23S rRNA
FOF52_16850	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FOF52_16855	COG0629	single-stranded DNA binding
FOF52_16860	COG0360	Binds together with S18 to 16S ribosomal RNA
FOF52_16870	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FOF52_16925	COG2018	Roadblock/LC7 domain
FOF52_16950	COG0515	serine threonine protein kinase
FOF52_16950	COG2815	serine threonine protein kinase
FOF52_16955	COG1595	DNA-templated transcription, initiation
FOF52_16965	COG0492	ferredoxin-NADP+ reductase activity
FOF52_16970	COG3118	belongs to the thioredoxin family
FOF52_16980	COG1192	Involved in chromosome partitioning
FOF52_16985	COG0357	Ribosomal RNA small subunit methyltransferase G
FOF52_16990	COG1847	R3H domain protein
FOF52_16995	COG0706	membrane insertase activity
FOF52_17000	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FOF52_17005	COG0594	ribonuclease P activity
FOF52_17010	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FOF52_17015	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FOF52_17020	COG0592	DNA-directed DNA polymerase activity
FOF52_17025	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FOF52_17030	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FOF52_17035	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
FOF52_17040	COG0187	DNA topoisomerase II activity
FOF52_17045	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FOF52_17095	COG2089	acid synthase
FOF52_17100	COG1216	Glycosyl transferase, family 2
FOF52_17110	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FOF52_17110	COG2755	lipolytic protein G-D-S-L family
FOF52_17135	COG0438	transferase activity, transferring glycosyl groups
FOF52_17160	COG1482	cell wall glycoprotein biosynthetic process
FOF52_17165	COG1316	TRANSCRIPTIONal
FOF52_17175	COG0305	Participates in initiation and elongation during chromosome replication
FOF52_17195	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FOF52_17220	COG1674	ftsk spoiiie
FOF52_17275	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FOF52_17280	COG0583	DNA-binding transcription factor activity
FOF52_17290	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FOF52_17345	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FOF52_17350	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FOF52_17360	COG3387	PFAM Glycoside hydrolase 15-related
FOF52_17365	COG0587	DNA-directed DNA polymerase activity
FOF52_17425	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FOF52_17430	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FOF52_17465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FOF52_17485	COG4974	Belongs to the 'phage' integrase family
FOF52_17595	COG1674	ftsk spoiiie
FOF52_17605	COG2259	Doxx family
FOF52_17630	COG2183	response to ionizing radiation
FOF52_17645	COG4585	Histidine kinase
FOF52_17650	COG2197	response regulator
FOF52_17685	COG0039	L-malate dehydrogenase activity
FOF52_17690	COG0592	DNA-directed DNA polymerase activity
FOF52_17735	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
FOF52_17745	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_17790	COG0604	alcohol dehydrogenase
FOF52_17790	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_17790	COG3321	synthase
FOF52_17815	COG1960	acyl-CoA dehydrogenase activity
FOF52_17855	COG3629	intracellular signal transduction
FOF52_17855	COG3903	Transcriptional regulator
FOF52_17880	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FOF52_17920	COG2315	Protein conserved in bacteria
FOF52_17930	COG4585	Histidine kinase
FOF52_17935	COG2197	response regulator
FOF52_17955	COG0488	(ABC) transporter
FOF52_17990	COG1063	alcohol dehydrogenase
FOF52_17995	COG2208	phosphoserine phosphatase activity
FOF52_18000	COG2208	phosphoserine phosphatase activity
FOF52_18005	COG1408	metallophosphoesterase
FOF52_18015	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FOF52_18050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FOF52_18080	COG1366	Belongs to the anti-sigma-factor antagonist family
FOF52_18085	COG1111	helicase
FOF52_18085	COG1205	dead DEAH box helicase
FOF52_18135	COG0596	Alpha beta hydrolase
FOF52_18145	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
FOF52_18155	COG0560	Phosphoserine phosphatase
FOF52_18155	COG3830	Belongs to the UPF0237 family
FOF52_18175	COG1119	ATPase activity
FOF52_18190	COG0446	pyridine nucleotide-disulphide oxidoreductase
FOF52_18200	COG1309	transcriptional regulator
FOF52_18205	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FOF52_18210	COG2843	Capsule synthesis protein
FOF52_18255	COG3866	Pectate lyase
FOF52_18265	COG0657	acetylesterase activity
FOF52_18270	COG0047	phosphoribosylformylglycinamidine synthase activity
FOF52_18280	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FOF52_18305	COG4176	ABC-type proline glycine betaine transport system permease component
FOF52_18320	COG1012	belongs to the aldehyde dehydrogenase family
FOF52_18325	COG1476	TRANSCRIPTIONal
FOF52_18335	COG1131	(ABC) transporter
FOF52_18345	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FOF52_18395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FOF52_18400	COG1846	Transcriptional regulator
FOF52_18415	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FOF52_18420	COG0140	phosphoribosyl-ATP diphosphatase activity
FOF52_18425	COG0300	oxidoreductase activity
FOF52_18435	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FOF52_18440	COG1595	DNA-templated transcription, initiation
FOF52_18450	COG0022	dehydrogenase e1 component
FOF52_18455	COG0508	dehydrogenase complex catalyzes the overall conversion of
FOF52_18465	COG5002	protein histidine kinase activity
FOF52_18465	COG2176	DNA-directed DNA polymerase activity
FOF52_18470	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FOF52_18480	COG0706	membrane insertase activity
FOF52_18490	COG0181	hydroxymethylbilane synthase activity
FOF52_18510	COG0791	NLP P60 protein
FOF52_18535	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FOF52_18565	COG0247	lactate metabolic process
FOF52_18565	COG2181	nitrate reductase activity
FOF52_18570	COG0443	Heat shock 70 kDa protein
FOF52_18575	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FOF52_18580	COG0484	heat shock protein binding
FOF52_18585	COG0789	Transcriptional regulator
FOF52_18590	COG0542	response to heat
FOF52_18620	COG1960	acyl-CoA dehydrogenase activity
FOF52_18630	COG0215	cysteine-tRNA ligase activity
FOF52_18635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FOF52_18655	COG1404	Belongs to the peptidase S8 family
FOF52_18690	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FOF52_18695	COG0459	protein refolding
FOF52_18700	COG0494	nUDIX hydrolase
FOF52_18730	COG1278	Cold shock
FOF52_18755	COG2890	protein-(glutamine-N5) methyltransferase activity
FOF52_18765	COG2252	PERMEase
FOF52_18775	COG2814	Major facilitator Superfamily
FOF52_18780	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
FOF52_18795	COG0584	glycerophosphoryl diester phosphodiesterase
FOF52_18820	COG0259	pyridoxamine-phosphate oxidase activity
FOF52_18830	COG1366	Belongs to the anti-sigma-factor antagonist family
FOF52_18830	COG2172	sigma factor antagonist activity
FOF52_18830	COG2208	phosphoserine phosphatase activity
FOF52_18835	COG1295	ribonuclease BN
FOF52_18835	COG1959	2 iron, 2 sulfur cluster binding
FOF52_18845	COG0183	Belongs to the thiolase family
FOF52_18860	COG2205	protein histidine kinase activity
FOF52_18865	COG0745	RESPONSE REGULATOR receiver
FOF52_18875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FOF52_18960	COG2353	YceI-like domain
FOF52_18965	COG0018	arginyl-trna synthetase
FOF52_18975	COG0416	fatty acid biosynthetic process
FOF52_18980	COG1509	lysine 2,3-aminomutase activity
FOF52_18985	COG1940	carbohydrate kinase activity
FOF52_19000	COG1024	Enoyl-CoA hydratase
FOF52_19060	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FOF52_19065	COG1012	belongs to the aldehyde dehydrogenase family
FOF52_19070	COG3842	ATPase activity
FOF52_19080	COG1176	ABC-type spermidine putrescine transport system, permease component I
FOF52_19085	COG1177	transmembrane transport
FOF52_19090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FOF52_19100	COG5002	protein histidine kinase activity
FOF52_19100	COG2205	protein histidine kinase activity
FOF52_19100	COG0784	Response regulator, receiver
FOF52_19115	COG2197	response regulator
FOF52_19120	COG4585	Histidine kinase
FOF52_19160	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_19165	COG0631	protein serine/threonine phosphatase activity
FOF52_19170	COG2372	response to copper ion
FOF52_19180	COG0456	acetyltransferase
FOF52_19190	COG1917	Cupin 2, conserved barrel domain protein
FOF52_19195	COG5285	phytanoyl-CoA dioxygenase
FOF52_19205	COG0765	amino acid transport
FOF52_19210	COG0765	amino acid transport
FOF52_19215	COG1126	abc transporter atp-binding protein
FOF52_19230	COG1492	cobalamin metabolic process
FOF52_19240	COG1797	cobyrinic acid a,c-diamide synthase activity
FOF52_19295	COG1120	ATPase activity
FOF52_19300	COG4139	cobalamin transport
FOF52_19325	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FOF52_19330	COG0494	nUDIX hydrolase
FOF52_19330	COG0406	alpha-ribazole phosphatase activity
FOF52_19395	COG1120	ATPase activity
FOF52_19400	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOF52_19405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOF52_19420	COG2301	Belongs to the HpcH HpaI aldolase family
FOF52_19430	COG0745	RESPONSE REGULATOR receiver
FOF52_19440	COG2188	Transcriptional regulator
FOF52_19460	COG1320	monovalent cation:proton antiporter activity
FOF52_19465	COG2212	antiporter activity
FOF52_19475	COG0651	ATP synthesis coupled electron transport
FOF52_19480	COG1006	Multisubunit Na H antiporter MnhC subunit
FOF52_19485	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FOF52_19485	COG2111	Na H antiporter
FOF52_19490	COG1846	Transcriptional regulator
FOF52_19500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FOF52_19520	COG0589	response to stress
FOF52_19530	COG3384	dioxygenase
FOF52_19535	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FOF52_19540	COG3321	synthase
FOF52_19540	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_19540	COG0604	alcohol dehydrogenase
FOF52_19545	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_19600	COG1876	peptidase activity
FOF52_19605	COG1970	mechanosensitive ion channel activity
FOF52_19630	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FOF52_19640	COG0315	cyclic pyranopterin monophosphate synthase activity
FOF52_19645	COG0521	Mo-molybdopterin cofactor biosynthetic process
FOF52_19645	COG0315	cyclic pyranopterin monophosphate synthase activity
FOF52_19650	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FOF52_19675	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FOF52_19705	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FOF52_19715	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FOF52_19735	COG0084	hydrolase, TatD family'
FOF52_19740	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FOF52_19775	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FOF52_19785	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FOF52_19795	COG0488	(ABC) transporter
FOF52_19805	COG1846	Transcriptional regulator
FOF52_19825	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FOF52_19830	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FOF52_19835	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FOF52_19840	COG0193	aminoacyl-tRNA hydrolase activity
FOF52_19845	COG1218	3'(2'),5'-bisphosphate nucleotidase
FOF52_19865	COG1959	2 iron, 2 sulfur cluster binding
FOF52_19870	COG1017	nitric oxide dioxygenase activity
FOF52_19870	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FOF52_19885	COG0529	Catalyzes the synthesis of activated sulfate
FOF52_19900	COG0730	response to heat
FOF52_19905	COG0148	phosphopyruvate hydratase activity
FOF52_19925	COG1252	NADH dehydrogenase
FOF52_19935	COG1012	belongs to the aldehyde dehydrogenase family
FOF52_19940	COG0506	proline dehydrogenase activity
FOF52_19955	COG0183	Belongs to the thiolase family
FOF52_19960	COG2755	lipolytic protein G-D-S-L family
FOF52_19990	COG0110	maltose O-acetyltransferase activity
FOF52_20015	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
FOF52_20030	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FOF52_20040	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FOF52_20050	COG1331	Highly conserved protein containing a thioredoxin domain
FOF52_20060	COG0515	serine threonine protein kinase
FOF52_20060	COG2815	serine threonine protein kinase
FOF52_20070	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FOF52_20075	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FOF52_20085	COG0114	fumarate hydratase activity
FOF52_20095	COG1131	(ABC) transporter
FOF52_20140	COG1722	exodeoxyribonuclease VII activity
FOF52_20145	COG1570	exodeoxyribonuclease VII activity
FOF52_20160	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FOF52_20170	COG1322	Protein conserved in bacteria
FOF52_20175	COG0012	GTP binding
FOF52_20270	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FOF52_20280	COG1994	Peptidase M50
FOF52_20310	COG2171	N-acyltransferase activity
FOF52_20315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FOF52_20330	COG2818	Glycosylase
FOF52_20345	COG1024	Enoyl-CoA hydratase
FOF52_20355	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FOF52_20360	COG1595	DNA-templated transcription, initiation
FOF52_20375	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FOF52_20395	COG0613	PHP domain protein
FOF52_20410	COG0513	Belongs to the DEAD box helicase family
FOF52_20425	COG0668	transmembrane transport
FOF52_20495	COG1946	Acyl-CoA thioesterase
FOF52_20520	COG0415	Belongs to the DNA photolyase family
FOF52_20540	COG0314	molybdopterin synthase activity
FOF52_20545	COG3480	Lon protease (S16) C-terminal proteolytic domain
FOF52_20555	COG1615	UPF0182 protein
FOF52_20590	COG0483	inositol monophosphate 1-phosphatase activity
FOF52_20600	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FOF52_20615	COG2135	peptidase activity
FOF52_20620	COG2226	methyltransferase
FOF52_20625	COG1595	DNA-templated transcription, initiation
FOF52_20630	COG5662	AntiSigma factor
FOF52_20635	COG2199	diguanylate cyclase activity
FOF52_20635	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FOF52_20645	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
FOF52_20660	COG2188	Transcriptional regulator
FOF52_20675	COG1597	lipid kinase activity
FOF52_20690	COG2172	sigma factor antagonist activity
FOF52_20700	COG1126	abc transporter atp-binding protein
FOF52_20705	COG0765	amino acid transport
FOF52_20710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FOF52_20715	COG0281	malic enzyme
FOF52_20735	COG0508	dehydrogenase complex catalyzes the overall conversion of
FOF52_20735	COG0567	Dehydrogenase, E1 component
FOF52_20740	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_20760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FOF52_20770	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FOF52_20775	COG0438	transferase activity, transferring glycosyl groups
FOF52_20785	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FOF52_20805	COG0616	signal peptide processing
FOF52_20820	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FOF52_20830	COG0366	Alpha amylase catalytic
FOF52_20835	COG0366	Alpha amylase catalytic
FOF52_20840	COG0058	SHG alpha-glucan phosphorylase activity
FOF52_20850	COG1122	ATPase activity
FOF52_20880	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FOF52_20915	COG0482	sulfurtransferase activity
FOF52_20930	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FOF52_20940	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FOF52_20945	COG0154	amidase activity
FOF52_20960	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FOF52_20965	COG3300	MHYT domain
FOF52_20965	COG5001	Diguanylate cyclase
FOF52_20980	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FOF52_20985	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FOF52_20990	COG0473	3-isopropylmalate dehydrogenase activity
FOF52_20995	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FOF52_21000	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FOF52_21015	COG5297	Belongs to the glycosyl hydrolase family 6
FOF52_21020	COG0179	Fumarylacetoacetate (FAA) hydrolase
FOF52_21030	COG2311	Membrane
FOF52_21040	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FOF52_21060	COG2133	pyrroloquinoline quinone binding
FOF52_21070	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FOF52_21075	COG0066	3-isopropylmalate dehydratase activity
FOF52_21090	COG1920	GTP binding
FOF52_21100	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FOF52_21110	COG0626	cystathionine gamma-synthase activity
FOF52_21115	COG1181	Belongs to the D-alanine--D-alanine ligase family
FOF52_21130	COG4988	ABC transporter
FOF52_21135	COG1294	oxidase, subunit
FOF52_21140	COG1271	oxidase subunit
FOF52_21175	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FOF52_21180	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FOF52_21185	COG0742	ribosomal rna small subunit methyltransferase
FOF52_21190	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FOF52_21195	COG1399	metal-binding, possibly nucleic acid-binding protein
FOF52_21200	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FOF52_21205	COG0571	ribonuclease III activity
FOF52_21210	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FOF52_21215	COG1254	Belongs to the acylphosphatase family
FOF52_21230	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FOF52_21235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOF52_21240	COG0552	protein localization to endoplasmic reticulum
FOF52_21250	COG1131	(ABC) transporter
FOF52_21255	COG1510	regulation of RNA biosynthetic process
FOF52_21275	COG0228	four-way junction DNA binding
FOF52_21280	COG1837	Belongs to the UPF0109 family
FOF52_21285	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FOF52_21290	COG0336	Belongs to the RNA methyltransferase TrmD family
FOF52_21295	COG0335	large ribosomal subunit rRNA binding
FOF52_21315	COG0792	nuclease activity
FOF52_21340	COG4974	Belongs to the 'phage' integrase family
FOF52_21350	COG0052	Belongs to the universal ribosomal protein uS2 family
FOF52_21355	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FOF52_21360	COG0528	UMP kinase activity
FOF52_21365	COG0233	cytoplasmic translational termination
FOF52_21385	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FOF52_21395	COG1522	sequence-specific DNA binding
FOF52_21405	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FOF52_21465	COG1105	Belongs to the carbohydrate kinase PfkB family
FOF52_21475	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_21505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FOF52_21535	COG1401	restriction endodeoxyribonuclease activity
FOF52_21565	COG1201	RNA secondary structure unwinding
FOF52_21575	COG2409	Drug exporters of the RND superfamily
FOF52_21585	COG0456	acetyltransferase
FOF52_21625	COG0318	PFAM AMP-dependent synthetase and ligase
FOF52_21630	COG3619	membrane
FOF52_21640	COG1401	restriction endodeoxyribonuclease activity
FOF52_21700	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair