locus-tag class description Tfu_0001 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) Tfu_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) Tfu_0003 ENOG4108J5G 6-phosphogluconate dehydrogenase Tfu_0004 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) Tfu_0005 ENOG4105K7N UPF0232 protein Tfu_0006 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Tfu_0007 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Tfu_0010 ENOG4105D2T synthase Tfu_0011 ENOG4107QRS glycosyltransferase group 2 family protein Tfu_0016 ENOG4105EIP mannose-6-phosphate isomerase Tfu_0017 ENOG4108KGH TRANSCRIPTIONal Tfu_0019 ENOG4105CDU Replicative dna helicase Tfu_0027 ENOG4108Z6B deaminase Tfu_0029 ENOG4105GZI Transcriptional regulator Tfu_0031 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) Tfu_0043 ENOG4105CFH Aspartokinase Tfu_0044 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) Tfu_0045 ENOG41083VQ Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) Tfu_0046 ENOG4105BZP glycoside hydrolase 15-related Tfu_0047 ENOG4105C0B DNA polymerase III (alpha subunit) Tfu_0050 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) Tfu_0060 ENOG4105DNP FAD linked oxidase domain protein Tfu_0061 ENOG4107QRT dEAD DEAH box helicase Tfu_0064 ENOG41088T4 Helicase IV Tfu_0068 ENOG4105C1G acyl-Coa dehydrogenase Tfu_0071 ENOG4108VC7 Protein of unknown function (DUF2587) Tfu_0075 ENOG4105C0Z ABC transporter Tfu_0076 ENOG4108IV0 ABC, transporter Tfu_0077 ENOG4105C32 Amino acid ABC transporter (Permease) Tfu_0079 ENOG4105D74 hydrolase Tfu_0083 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) Tfu_0086 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) Tfu_0092 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) Tfu_0096 ENOG4107TIF Phenazine biosynthesis protein, PhzF family Tfu_0097 ENOG4108JW7 Maf-like protein Tfu_0100 ENOG4105BZM domain protein Tfu_0109 ENOG4105BZ4 penicillin-binding protein Tfu_0116 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) Tfu_0119 ENOG4105P8F nudix hydrolase Tfu_0122 ENOG4105WN5 stage II sporulation protein Tfu_0123 ENOG4108I5C dEAD DEAH box helicase Tfu_0132 ENOG4105D74 hydrolase Tfu_0134 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Tfu_0135 ENOG4105CVJ phosphoglycerate mutase Tfu_0136 ENOG4105EAC phosphoserine phosphatase Tfu_0139 ENOG4105DKW ABC transporter Tfu_0143 ENOG4108SGK Tetr family transcriptional regulator Tfu_0144 ENOG4105PNM synthesis protein Tfu_0150 ENOG4107QVI Methyltransferase, type 11 Tfu_0153 ENOG4108J20 pectate lyase Tfu_0156 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I Tfu_0158 ENOG4107QIK phosphoribosylformylglycinamidine synthase Tfu_0162 ENOG4105F2Z 3-oxoadipate enol-lactonase Tfu_0165 ENOG4105WX6 Membrane Tfu_0166 ENOG4107QJZ Glycosyl transferase, family 2 Tfu_0169 ENOG4108IAJ Nad-dependent epimerase dehydratase Tfu_0172 ENOG41080RH Thioredoxin Tfu_0174 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) Tfu_0175 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase Tfu_0176 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr Tfu_0178 ENOG410839H phosphoribosylformylglycinamidine synthase Tfu_0179 ENOG4105EMN RNA polymerase sigma factor Tfu_0181 ENOG4105CPP Dehydrogenase, E1 component Tfu_0182 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 Tfu_0184 ENOG4105C94 Transporter Tfu_0185 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins Tfu_0188 ENOG4108RTU Aldolase Tfu_0193 ENOG4108Z0R Transferase Tfu_0195 ENOG4105DF6 Fe-S oxidoreductase Tfu_0196 ENOG4105CFG Acts as a chaperone (By similarity) Tfu_0197 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ Tfu_0198 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) Tfu_0199 ENOG4105KNI merR family transcriptional Regulator Tfu_0200 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Tfu_0205 ENOG4108D32 Methyltransferase Tfu_0210 ENOG4105CSU acyl-Coa dehydrogenase Tfu_0212 ENOG4105C8N cysteinyl-tRNA synthetase Tfu_0213 ENOG4105C2N RNA methyltransferase TrmH family group 3 Tfu_0214 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Tfu_0224 ENOG4108K4C ec 3.1.3.12 Tfu_0225 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase Tfu_0228 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) Tfu_0234 ENOG4105VEQ Cold shock protein Tfu_0240 ENOG4105C7N Xanthine uracil vitamin C permease Tfu_0241 ENOG4105FS7 Transcriptional regulator Tfu_0243 ENOG4108784 2'-5' rna ligase Tfu_0245 ENOG4107T6V glycerophosphoryl diester phosphodiesterase Tfu_0246 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) Tfu_0248 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) Tfu_0251 ENOG4107S2Z UPF0761 membrane protein Tfu_0253 ENOG4105F2C Acetyl-CoA acetyltransferase Tfu_0256 ENOG4105BZU Histidine kinase Tfu_0257 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Tfu_0259 ENOG4108RVA ribokinase Tfu_0268 ENOG4108YYC ycei family Tfu_0269 ENOG4105C75 arginyL-tRNA synthetase Tfu_0271 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) Tfu_0272 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein Tfu_0273 ENOG4105DKQ ROK family Tfu_0278 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) Tfu_0279 ENOG4105C26 Dehydrogenase Tfu_0280 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Tfu_0282 ENOG4105F38 ABC transporter, permease Tfu_0283 ENOG4105D38 putrescine abc transporter Tfu_0284 ENOG4105CJP fad dependent oxidoreductase Tfu_0285 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Tfu_0286 ENOG4105BZU Histidine kinase Tfu_0288 ENOG4108S01 response regulator Tfu_0289 ENOG4105BZU Histidine kinase Tfu_0295 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) Tfu_0297 ENOG4108ZF3 Phosphatase Tfu_0298 ENOG4105FXM Copper resistance protein Tfu_0299 ENOG4105KRM Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) Tfu_0300 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase Tfu_0302 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) Tfu_0311 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) Tfu_0312 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase Tfu_0314 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase Tfu_0317 ENOG41081F0 Precorrin-8x methylmutase Tfu_0319 ENOG4105CTK cobaltochelatase, cobn subunit Tfu_0323 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) Tfu_0328 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein Tfu_0330 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) Tfu_0336 ENOG4105E0A ABC, transporter Tfu_0337 ENOG4105TVJ transport system, permease Tfu_0338 ENOG4105DQ5 transport system permease protein Tfu_0341 ENOG4105CI0 Citrate lyase Tfu_0344 ENOG41062D9 Histidine kinase Tfu_0345 ENOG4105KJM monovalent cation h antiporter subunit g Tfu_0346 ENOG410684G monovalent cation H antiporter subunit F Tfu_0348 ENOG4108JPZ Monovalent cation H antiporter subunit D Tfu_0349 ENOG4105MKQ Monovalent cation H antiporter subunit C Tfu_0350 ENOG4105D65 subunit l Tfu_0351 ENOG4105FS7 Transcriptional regulator Tfu_0353 ENOG4105C0H protease Tfu_0354 ENOG4105KHC sulfurtransferase Tfu_0357 ENOG4108YV4 Universal stress protein Tfu_0358 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b Tfu_0359 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) Tfu_0361 ENOG4105CHR reductase Tfu_0368 ENOG4108UZE carboxy-peptidase Tfu_0372 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase Tfu_0373 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase Tfu_0375 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Tfu_0376 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Tfu_0381 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) Tfu_0389 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) Tfu_0397 ENOG4105EYH Exonuclease Tfu_0398 ENOG4105F8V Hydrolase, tatD family Tfu_0399 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Tfu_0402 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) Tfu_0405 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) Tfu_0407 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) Tfu_0408 ENOG4108Z4X TRANSCRIPTIONal Tfu_0409 ENOG4105C5H ABC transporter Tfu_0411 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes Tfu_0414 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) Tfu_0415 ENOG4105C5T Phosphoribosyl pyrophosphate synthase Tfu_0416 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) Tfu_0417 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) Tfu_0418 ENOG4108RM3 Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I- 1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F- 6-P)) and AMP in vitro, but this might has no significance in vivo Tfu_0419 ENOG4105C11 sulfate adenylyltransferase), subunit 2 Tfu_0422 ENOG41081JD Transcriptional regulator Tfu_0425 ENOG4107T1U Catalyzes the synthesis of activated sulfate (By similarity) Tfu_0428 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) Tfu_0432 ENOG4105CEP NADH dehydrogenase Tfu_0433 ENOG4105C26 Dehydrogenase Tfu_0436 ENOG4105CHU acetyl-coa acetyltransferase Tfu_0439 ENOG4108UW5 maltose o-acetyltransferase Tfu_0442 ENOG4107KWJ von Willebrand factor, type A Tfu_0443 ENOG4105EET magnesium chelatase Tfu_0446 ENOG4105VQU rdd domain containing protein Tfu_0447 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) Tfu_0449 ENOG4105T1M mycothiol conjugate amidase mca Tfu_0451 ENOG4105C7Z Conserved Protein Tfu_0454 ENOG4105D9P serine threonine protein kinase Tfu_0455 ENOG4105EMN RNA polymerase sigma factor Tfu_0456 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) Tfu_0457 ENOG4108IAB Phoh family Tfu_0459 ENOG4105C9Q fumarate hydratase class II Tfu_0467 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) Tfu_0468 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) Tfu_0471 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) Tfu_0473 ENOG4105C3G gtp-binding protein Tfu_0477 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) Tfu_0484 ENOG4106T9R serine protease Tfu_0486 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) Tfu_0488 ENOG4107XZ0 Peptidase M50 Tfu_0491 ENOG4108Z4U Ferredoxin Tfu_0494 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) Tfu_0495 ENOG4107R4C succinyl-diaminopimelate desuccinylase Tfu_0496 ENOG4108URH decarboxylase Tfu_0498 ENOG4108R3E Dna-3-methyladenine glycosylase i Tfu_0501 ENOG4105CGU Enoyl-CoA hydratase Tfu_0503 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) Tfu_0504 ENOG4105DU6 RNA polymerase Tfu_0507 ENOG4105C0H protease Tfu_0511 ENOG4105DB7 PHP domain protein Tfu_0514 ENOG4105C1J atp-dependent rna helicase Tfu_0523 ENOG4105C4R Atp-dependent dna helicase Tfu_0526 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) Tfu_0531 ENOG4105C29 acyl-CoA thioesterase Tfu_0532 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) Tfu_0534 ENOG4105CVP deoxyribo-dipyrimidine photolyase Tfu_0539 ENOG41063PX domain protein Tfu_0541 ENOG4105DJZ UPF0182 protein Tfu_0542 ENOG4107TK4 histidinol-phosphate phosphatase Tfu_0543 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) Tfu_0544 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase Tfu_0546 ENOG4108RAV Conserved protein Tfu_0547 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) Tfu_0548 ENOG4105EMN RNA polymerase sigma factor Tfu_0549 ENOG4105WMN AntiSigma factor Tfu_0550 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Tfu_0554 ENOG4105FDP GntR family transcriptional regulator Tfu_0557 ENOG4107TE5 Lipid kinase Tfu_0560 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) Tfu_0562 ENOG4105C6K Malic enzyme Tfu_0566 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 Tfu_0570 ENOG4105BZ4 penicillin-binding protein Tfu_0572 ENOG4108M6P methyltransferase Tfu_0573 ENOG4108TJN glycosyl transferase group 1 Tfu_0575 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) Tfu_0577 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) Tfu_0578 ENOG4105MXW flavin reductase domain protein, FMN-binding Tfu_0582 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) Tfu_0584 ENOG4105CG3 alpha amylase, catalytic region Tfu_0585 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) Tfu_0586 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) Tfu_0588 ENOG4108JJB ABC transporter Tfu_0589 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) Tfu_0592 ENOG4105D9P serine threonine protein kinase Tfu_0594 ENOG4105C10 Electron transfer flavoprotein Tfu_0597 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) Tfu_0601 ENOG4107TPY serine threonine protein kinase Tfu_0603 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) Tfu_0604 ENOG4105BZU Histidine kinase Tfu_0605 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) Tfu_0606 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Tfu_0609 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) Tfu_0610 ENOG4105BZU Histidine kinase Tfu_0613 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase Tfu_0614 ENOG4108JQ1 Dehydrogenase Tfu_0615 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) Tfu_0616 ENOG4105CM2 brancheD-chain amino acid aminotransferase Tfu_0617 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) Tfu_0620 ENOG41065HY 1,4-beta-cellobiosidase Tfu_0621 ENOG4105ERH Fumarylacetoacetate hydrolase Tfu_0623 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) Tfu_0624 ENOG4105D8V Glucose sorbosone dehydrogenase Tfu_0625 ENOG41069M3 Transcriptional regulator Tfu_0626 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Tfu_0627 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Tfu_0628 ENOG4105K70 DNA-binding protein Tfu_0629 ENOG4105ME0 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor (By similarity) Tfu_0631 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase Tfu_0632 ENOG4105C28 cystathionine Tfu_0633 ENOG4105CPF Cell wall formation (By similarity) Tfu_0635 ENOG4108JJ8 (ABC) transporter Tfu_0636 ENOG4108JJ9 ABC, transporter Tfu_0637 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii Tfu_0638 ENOG4105C4M (Ubiquinol oxidase) subunit I Tfu_0645 ENOG4105VB9 50S ribosomal protein l28 Tfu_0646 ENOG4105CB5 ATP-dependent DNA helicase recG Tfu_0647 ENOG4106H78 methyltransferase Tfu_0648 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) Tfu_0650 ENOG41084BZ 50S ribosomal protein L32 Tfu_0651 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) Tfu_0652 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) Tfu_0653 ENOG4108375 Acylphosphatase (EC 3.6.1.7) Tfu_0656 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) Tfu_0657 ENOG4105EHG Permease protein Tfu_0658 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) Tfu_0662 ENOG4105K5M 30s ribosomal protein S16 Tfu_0663 ENOG41082KU UPF0109 protein Tfu_0664 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) Tfu_0665 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) Tfu_0666 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) Tfu_0669 ENOG41080R2 UPF0102 protein Tfu_0670 ENOG4105C0P Mg chelatase subunit ChlI Tfu_0674 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Tfu_0676 ENOG4105CE9 30S ribosomal protein S2 Tfu_0677 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) Tfu_0678 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) Tfu_0679 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) Tfu_0683 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs Tfu_0684 ENOG4108ZRZ Transcriptional regulator (AsnC family) Tfu_0686 ENOG4105C8Y Acetylornithine aminotransferase Tfu_0687 ENOG4105C26 Dehydrogenase Tfu_0696 ENOG4105DE4 1-phosphofructokinase Tfu_0701 ENOG4107QPV Serine Threonine protein kinase Tfu_0703 ENOG4105D7V transposase Tfu_0712 ENOG4107QRT dEAD DEAH box helicase Tfu_0724 ENOG4105CVR type I restriction-modification system Tfu_0725 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) Tfu_0735 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Tfu_0739 ENOG4105D4P Coproporphyrinogen iii oxidase Tfu_0742 ENOG4108ZG0 Ompa motb domain protein Tfu_0744 ENOG4105C26 Dehydrogenase Tfu_0748 ENOG4105DZP Membrane-associated zinc metalloprotease Tfu_0749 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) Tfu_0751 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) Tfu_0753 ENOG4107T3P ABC, transporter Tfu_0754 ENOG41080XS Cobyrinic acid ac-diamide synthase Tfu_0759 ENOG4105CUT histidyl-tRNA synthetase Tfu_0761 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving Tfu_0765 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii Tfu_0766 ENOG4105C4M (Ubiquinol oxidase) subunit I Tfu_0767 ENOG4105WH1 Two component transcriptional regulator luxr family Tfu_0768 ENOG4105BZU Histidine kinase Tfu_0769 ENOG4108RNG Permease of the drug metabolite transporter Tfu_0772 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) Tfu_0775 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) Tfu_0778 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) Tfu_0780 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) Tfu_0781 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) Tfu_0783 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) Tfu_0784 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) Tfu_0785 ENOG4105C1V Peptidase, M16 Tfu_0786 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) Tfu_0787 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) Tfu_0790 ENOG41082T9 Membrane Tfu_0791 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Tfu_0792 ENOG4105CN5 Metallo-Beta-Lactamase Tfu_0793 ENOG4107QZI cell division protein FtsK Tfu_0795 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) Tfu_0797 ENOG4105CEV competence damage-inducible protein Tfu_0798 ENOG4105WBV Transcriptional regulator Tfu_0801 ENOG4105XYF acetyltransferase Tfu_0803 ENOG4107KFM Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) Tfu_0803 ENOG4107KFM Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) Tfu_0804 ENOG4105KC9 Modulates RecA activity (By similarity) Tfu_0805 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) Tfu_0807 ENOG4105DRP amino acid AbC transporter Tfu_0808 ENOG4108Q1T ABC transporter Tfu_0809 ENOG4107UBR Extracellular solute-binding protein family 3 Tfu_0810 ENOG4105CDA abc transporter atp-binding protein Tfu_0811 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) Tfu_0815 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) Tfu_0816 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) Tfu_0819 ENOG4107R9S Malate synthase Tfu_0820 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) Tfu_0821 ENOG4105CI2 imidazolone-5-propionate hydrolase Tfu_0825 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 Tfu_0827 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) Tfu_0829 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) Tfu_0830 ENOG4105EG2 ABC transporter, permease Tfu_0831 ENOG4105D56 permease protein Tfu_0833 ENOG4105CG3 alpha amylase, catalytic region Tfu_0838 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) Tfu_0839 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) Tfu_0843 ENOG4107YU2 histidine triad (hIT) protein Tfu_0845 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) Tfu_0848 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) Tfu_0849 ENOG4108FUF Transcriptional regulator, IclR family Tfu_0850 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) Tfu_0851 ENOG4105K4I Scp-like extracellular Tfu_0852 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) Tfu_0853 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) Tfu_0858 ENOG4105DIK (ABC) transporter Tfu_0861 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) Tfu_0862 ENOG4108UT2 hemolysin iii Tfu_0863 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) Tfu_0865 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein Tfu_0866 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) Tfu_0867 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Tfu_0873 ENOG4105CHH sulfate transporter Tfu_0874 ENOG4105F2Z 3-oxoadipate enol-lactonase Tfu_0875 ENOG4105CHU acetyl-coa acetyltransferase Tfu_0880 ENOG4107MHI Transcriptional regulator, MarR family Tfu_0881 ENOG4105BZ9 Cytochrome C oxidase, subunit I Tfu_0888 ENOG4105CHR reductase Tfu_0894 ENOG4105DKP glycosyl transferase, family 9 Tfu_0898 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) Tfu_0901 ENOG4107SMB hydrolase Family 5 Tfu_0907 ENOG4105MVE transcriptional regulator Tfu_0911 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Tfu_0912 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Tfu_0921 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) Tfu_0924 ENOG41065RQ ADP-ribosylation crystallin J1 Tfu_0927 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) Tfu_0928 ENOG4105D7K pfkb domain protein Tfu_0931 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) Tfu_0932 ENOG4108UMI ABC transporter, permease Tfu_0933 ENOG4105D01 (LipO)protein Tfu_0936 ENOG4105DRS transport system, permease Tfu_0937 ENOG4105CS2 ec 3.2.1.21 Tfu_0938 ENOG4105ETE Transcriptional regulator (LacI family Tfu_0941 ENOG4105GWZ Roadblock lc7 family protein Tfu_0944 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) Tfu_0946 ENOG4105C1G acyl-Coa dehydrogenase Tfu_0948 ENOG4107QX3 carboxylase Tfu_0950 ENOG4105CEP NADH dehydrogenase Tfu_0952 ENOG4105VPX protein, conserved in bacteria Tfu_0957 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) Tfu_0961 ENOG4105DCF alanine dehydrogenase Tfu_0963 ENOG4105E4J Cytochrome c oxidase caa3-type, assembly factor ctag-related protein Tfu_0980 ENOG4105DYW oxidoreductase Tfu_0981 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) Tfu_0982 ENOG4105C5F glutamine synthetase Tfu_0983 ENOG4105C4K Nad synthetase Tfu_0986 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) Tfu_0987 ENOG4105KPY Small multidrug resistance protein Tfu_0988 ENOG4105C5F glutamine synthetase Tfu_0991 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) Tfu_0992 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) Tfu_0995 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) Tfu_0996 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) Tfu_0997 ENOG4108YZT Adenosylcobinamide kinase Tfu_0999 ENOG4106D4I domain protein Tfu_1000 ENOG4107VRP DNA repair exonuclease Tfu_1004 ENOG4105CPC Aldo Keto reductase Tfu_1008 ENOG4105D0M Protease HtpX homolog Tfu_1010 ENOG4105BZW Glycerate kinase Tfu_1013 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) Tfu_1015 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) Tfu_1016 ENOG4105BZ9 Cytochrome C oxidase, subunit I Tfu_1019 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) Tfu_1020 ENOG4107EUI c reductase, iron-sulfur Tfu_1021 ENOG4107UDY cytochrome C Tfu_1022 ENOG4105CCU oxidase (Subunit III) Tfu_1024 ENOG4107S1N anthranilate phosphoribosyltransferase Tfu_1030 ENOG4105K4H Nlp p60 protein Tfu_1033 ENOG4105DKQ ROK family Tfu_1036 ENOG4105E9Q Acyl-transferase Tfu_1037 ENOG4105CTQ phosphohexokinase Tfu_1038 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) Tfu_1039 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase Tfu_1040 ENOG4105EQW The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) Tfu_1042 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) Tfu_1043 ENOG4105WHD thiamine biosynthesis protein ThiS Tfu_1046 ENOG4107Y5I Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) Tfu_1049 ENOG4105KEG ribosomal-protein-alanine acetyltransferase Tfu_1053 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) Tfu_1054 ENOG4105CXT aspartate transcarbamylase Tfu_1055 ENOG4105CD3 dihydroorotase Tfu_1056 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain Tfu_1057 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain Tfu_1058 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) Tfu_1059 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) Tfu_1060 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) Tfu_1062 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) Tfu_1063 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) Tfu_1065 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP Tfu_1066 ENOG4105DHF Membrane Tfu_1068 ENOG4105C1G acyl-Coa dehydrogenase Tfu_1073 ENOG4107RSZ Primosomal protein n' Tfu_1074 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) Tfu_1075 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) Tfu_1077 ENOG4105DJV ribulose-phosphate 3-epimerase Tfu_1080 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) Tfu_1081 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) Tfu_1083 ENOG4107WI4 Aldose-1-epimerase Tfu_1084 ENOG4105D9P serine threonine protein kinase Tfu_1090 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase Tfu_1091 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) Tfu_1092 ENOG4105D49 3-dehydroquinate synthase Tfu_1093 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) Tfu_1094 ENOG410803B Involved in the transcription termination process (By similarity) Tfu_1096 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) Tfu_1100 ENOG4105C7R Atpase associated with various cellular activities aaa_3 Tfu_1101 ENOG4108V6E Cell division protein mraZ Tfu_1102 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) Tfu_1104 ENOG4105CJN penicillin-binding protein Tfu_1105 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) Tfu_1107 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) Tfu_1108 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) Tfu_1110 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) Tfu_1111 ENOG4105DFU Cell wall formation (By similarity) Tfu_1113 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) Tfu_1114 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase Tfu_1116 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) Tfu_1120 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) Tfu_1133 ENOG4105D7V transposase Tfu_1134 ENOG4108RS6 transposase Tfu_1140 ENOG4105E9Z Nad-dependent epimerase dehydratase Tfu_1150 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) Tfu_1151 ENOG4105CIH Imidazole acetol-phosphate transaminase Tfu_1152 ENOG4105ECC imidazole-glycerol-phosphate dehydratase Tfu_1154 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) Tfu_1155 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase Tfu_1156 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) Tfu_1157 ENOG4105BZ1 (ABC) transporter Tfu_1158 ENOG4105BZ1 (ABC) transporter Tfu_1159 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase Tfu_1164 ENOG4105DK0 Indole-3-glycerol phosphate synthase Tfu_1165 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) Tfu_1166 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) Tfu_1169 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) Tfu_1173 ENOG4105CBC glutamate synthase Tfu_1178 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I Tfu_1182 ENOG4105C32 Amino acid ABC transporter (Permease) Tfu_1184 ENOG4105C0Z ABC transporter Tfu_1185 ENOG4108IV0 ABC, transporter Tfu_1186 ENOG4105CP9 extracellular ligand-binding receptor Tfu_1188 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) Tfu_1191 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) Tfu_1192 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) Tfu_1193 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) Tfu_1196 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) Tfu_1199 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) Tfu_1204 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) Tfu_1205 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) Tfu_1209 ENOG4105CAT Cytidine monophosphate kinase Tfu_1210 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) Tfu_1212 ENOG4107TK4 histidinol-phosphate phosphatase Tfu_1215 ENOG4105D8K carboxyl transferase Tfu_1217 ENOG4105KTE polyketide synthesis cyclase Tfu_1219 ENOG4105CZS beta-ketoacyl synthase Tfu_1224 ENOG4105CHR reductase Tfu_1225 ENOG4105Q56 cytochrome P450 Tfu_1228 ENOG4108JIK carboxylase Tfu_1229 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) Tfu_1230 ENOG4108RYK Nad-dependent epimerase dehydratase Tfu_1231 ENOG4108JA1 polyketide synthase Tfu_1232 ENOG4108Q5F Tetr family transcriptional regulator Tfu_1234 ENOG4108KC1 acyl-Coa dehydrogenase Tfu_1238 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Tfu_1239 ENOG4105CIR epoxide hydrolase Tfu_1250 ENOG4108N23 SpoOM-related protein Tfu_1259 ENOG4108UKI Enoyl-CoA hydratase Tfu_1260 ENOG4108UW5 maltose o-acetyltransferase Tfu_1261 ENOG4105KPY Small multidrug resistance protein Tfu_1265 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase Tfu_1266 ENOG41086D8 Transcriptional regulator Tfu_1267 ENOG4107ZXU DSBA oxidoreductase Tfu_1276 ENOG4105CB2 alcohol dehydrogenase Tfu_1278 ENOG4105CHU acetyl-coa acetyltransferase Tfu_1281 ENOG4105C1G acyl-Coa dehydrogenase Tfu_1282 ENOG4105C1G acyl-Coa dehydrogenase Tfu_1283 ENOG4107EXU Short-chain dehydrogenase reductase Sdr Tfu_1286 ENOG4105DJG MaoC domain protein dehydratase Tfu_1287 ENOG4105C26 Dehydrogenase Tfu_1288 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Tfu_1291 ENOG4105C32 Amino acid ABC transporter (Permease) Tfu_1293 ENOG4105C0Z ABC transporter Tfu_1294 ENOG4108IV0 ABC, transporter Tfu_1298 ENOG4105CHR reductase Tfu_1299 ENOG4108IPT Naphthoate synthase Tfu_1302 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha Tfu_1303 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Tfu_1305 ENOG4108IJ6 ABC transporter Tfu_1306 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component Tfu_1307 ENOG4105F38 ABC transporter, permease Tfu_1308 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Tfu_1309 ENOG4105C4Y ABC transporter Tfu_1310 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) Tfu_1311 ENOG4105KEG ribosomal-protein-alanine acetyltransferase Tfu_1314 ENOG4105EEI dihydropteroate synthase Tfu_1316 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) Tfu_1323 ENOG4108RS6 transposase Tfu_1324 ENOG4105D7V transposase Tfu_1328 ENOG4108UZX fmn reductase Tfu_1329 ENOG4105GR3 Histidine kinase Tfu_1330 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Tfu_1336 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) Tfu_1341 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) Tfu_1344 ENOG4105KT7 mgtC SapB transporter Tfu_1345 ENOG4105BZP glycoside hydrolase 15-related Tfu_1346 ENOG4108VW9 Membrane Tfu_1347 ENOG4105E5G Alpha beta hydrolase fold Tfu_1348 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Tfu_1353 ENOG41061MV Arylsulfatase Tfu_1357 ENOG4105E0Y RtcB Protein Tfu_1365 ENOG41080E2 ribosomal-protein-alanine acetyltransferase Tfu_1366 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) Tfu_1371 ENOG4107R37 Glutamate dehydrogenase Tfu_1372 ENOG4108KGH TRANSCRIPTIONal Tfu_1374 ENOG4105JXH GntR family transcriptional regulator Tfu_1375 ENOG4105DJ2 Major Facilitator Superfamily Tfu_1379 ENOG4105C1G acyl-Coa dehydrogenase Tfu_1384 ENOG4105W1Y Transcriptional regulator Tfu_1386 ENOG4105CRQ synthase (Component I) Tfu_1389 ENOG4105D22 carbon starvation protein Tfu_1398 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor Tfu_1400 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) Tfu_1403 ENOG4105WH1 Two component transcriptional regulator luxr family Tfu_1409 ENOG4108IPT Naphthoate synthase Tfu_1410 ENOG4107TCW O-succinylbenzoate synthase Tfu_1411 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) Tfu_1412 ENOG4108YV4 Universal stress protein Tfu_1413 ENOG4105E4F Isochorismate synthase Tfu_1414 ENOG4105F32 YngK protein Tfu_1416 ENOG4105CJN penicillin-binding protein Tfu_1423 ENOG4105EMY transcriptional regulator Tfu_1425 ENOG4107AQZ Membrane Tfu_1427 ENOG4105CF1 Alkylated DNA repair protein Tfu_1428 ENOG4105D7N magnesium and cobalt transport protein CorA Tfu_1451 ENOG4105M2Z protein tyrosine serine phosphatase Tfu_1459 ENOG4105KKX ATPase associated with various cellular activities aaa_5 Tfu_1461 ENOG4105DEG Vwa containing coxe family protein Tfu_1462 ENOG4105I82 acetyl xylan esterase Tfu_1468 ENOG4105D2B acyl-CoA dehydrogenase Tfu_1477 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Tfu_1481 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Tfu_1490 ENOG4107S2E monooxygenase Tfu_1492 ENOG4105DQ5 transport system permease protein Tfu_1493 ENOG4105TVJ transport system, permease Tfu_1494 ENOG4105E0A ABC, transporter Tfu_1497 ENOG4105FBW Monooxygenase Tfu_1499 ENOG4108UZX fmn reductase Tfu_1500 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) Tfu_1501 ENOG4107NHD transcriptional regulator Tfu_1502 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) Tfu_1503 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component Tfu_1504 ENOG4106FTQ Taurine ABC transporter, periplasmic Tfu_1506 ENOG4105EMN RNA polymerase sigma factor Tfu_1507 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) Tfu_1512 ENOG4105C1G acyl-Coa dehydrogenase Tfu_1514 ENOG4105D9P serine threonine protein kinase Tfu_1518 ENOG4105C2W permease Tfu_1520 ENOG4105CHU acetyl-coa acetyltransferase Tfu_1521 ENOG4108222 arsenate reductase Tfu_1523 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) Tfu_1526 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) Tfu_1527 ENOG4105K6T rare lipoprotein A Tfu_1528 ENOG4107Y70 Heat shock protein Tfu_1535 ENOG4105JXB ankyrin repeat-containing protein Tfu_1540 ENOG4107TTQ Alpha beta hydrolase fold Tfu_1541 ENOG4105CGK Exodeoxyribonuclease III Tfu_1547 ENOG410842T Pterin carbinolamine dehydratase Tfu_1556 ENOG41082BM Transcriptional regulator, arsr family Tfu_1559 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) Tfu_1560 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) Tfu_1561 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) Tfu_1562 ENOG4105K78 MarR family Transcriptional regulator Tfu_1564 ENOG4105UYK outer membrane protein a Tfu_1566 ENOG4105CAY ferredoxin--nadp reductase Tfu_1575 ENOG4105CMG Carbohydrate kinase Tfu_1587 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) Tfu_1589 ENOG4108VWQ crispr-associated protein Tfu_1605 ENOG4105DKQ ROK family Tfu_1608 ENOG4105E2R ROK family Tfu_1611 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component Tfu_1613 ENOG4105CJQ hydrolase, family 31 Tfu_1618 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component Tfu_1619 ENOG4105XN3 extracellular solute-binding protein family 1 Tfu_1620 ENOG4105ETE Transcriptional regulator (LacI family Tfu_1621 ENOG4108ZJ4 polysaccharide deacetylase Tfu_1622 ENOG4108IAJ Nad-dependent epimerase dehydratase Tfu_1624 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) Tfu_1625 ENOG4108UZ3 Transporter Tfu_1628 ENOG4105D63 family UPF0324 Tfu_1635 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) Tfu_1636 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) Tfu_1641 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Tfu_1646 ENOG4108IG5 Transcriptional regulator Tfu_1649 ENOG4105CH6 catalase Tfu_1652 ENOG4105ECP epimerase Tfu_1658 ENOG4108V5V Serine Threonine protein kinase Tfu_1660 ENOG4105D5U fad dependent oxidoreductase Tfu_1662 ENOG4105DIK (ABC) transporter Tfu_1667 ENOG4108Z6Z Transcriptional regulator Tfu_1669 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone Tfu_1671 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) Tfu_1673 ENOG4105DGI Alkaline phosphatase Tfu_1674 ENOG4105CPC Aldo Keto reductase Tfu_1676 ENOG4105C7R Atpase associated with various cellular activities aaa_3 Tfu_1678 ENOG4107QVM von Willebrand factor, type A Tfu_1680 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) Tfu_1682 ENOG4105CHR reductase Tfu_1683 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) Tfu_1685 ENOG4105C37 (CBS) domain Tfu_1686 ENOG4105C37 (CBS) domain Tfu_1687 ENOG4105CV8 reductase Tfu_1688 ENOG4105C26 Dehydrogenase Tfu_1694 ENOG410635A Membrane Tfu_1695 ENOG4105BZ9 Cytochrome C oxidase, subunit I Tfu_1697 ENOG4105BZ1 (ABC) transporter Tfu_1698 ENOG4105F95 Monooxygenase Tfu_1700 ENOG4105CHR reductase Tfu_1701 ENOG4105EXC Acyl-transferase Tfu_1702 ENOG410769Z extracellular solute-binding protein family 1 Tfu_1703 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component Tfu_1704 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component Tfu_1705 ENOG4105DDC Oxidoreductase domain protein Tfu_1710 ENOG4105ETE Transcriptional regulator (LacI family Tfu_1711 ENOG4105G3Z GntR family transcriptional regulator Tfu_1715 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Tfu_1716 ENOG4105CMT Dihydroxyacetone kinase Tfu_1717 ENOG4105DIA mandelate racemase muconate lactonizing Tfu_1722 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) Tfu_1726 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) Tfu_1728 ENOG4105C2C drug resistance transporter, Bcr CflA Tfu_1730 ENOG4105C3Q Glycosyl transferase, family 2 Tfu_1732 ENOG4105C3Q Glycosyl transferase, family 2 Tfu_1734 ENOG4105C2C drug resistance transporter, Bcr CflA Tfu_1740 ENOG4105C5Q Transcriptional regulator Tfu_1741 ENOG4105C7B Threonine dehydratase Tfu_1742 ENOG4107R8N Glycosyl transferase, family 2 Tfu_1744 ENOG4107T6F Xaa-Pro aminopeptidase Tfu_1751 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) Tfu_1753 ENOG4105C7H Helicase, RecD TraA family Tfu_1759 ENOG4105Q70 Tfu_1762 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) Tfu_1764 ENOG4105JNK Glycosyl transferase (Group 1 Tfu_1765 ENOG4105CQR helicase Tfu_1768 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) Tfu_1769 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) Tfu_1777 ENOG4105C1G acyl-Coa dehydrogenase Tfu_1782 ENOG4108IV0 ABC, transporter Tfu_1783 ENOG4105C0Z ABC transporter Tfu_1784 ENOG41061TZ Short-chain dehydrogenase reductase Sdr Tfu_1785 ENOG4105EMF GntR family transcriptional regulator Tfu_1786 ENOG4105CXK mandelate racemase muconate lactonizing Tfu_1788 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) Tfu_1789 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) Tfu_1790 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) Tfu_1791 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) Tfu_1794 ENOG4105CSH Transporter Tfu_1796 ENOG4105E5F proteasome Tfu_1808 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) Tfu_1809 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) Tfu_1817 ENOG4105WH1 Two component transcriptional regulator luxr family Tfu_1819 ENOG4108JQ6 ABC transporter Tfu_1822 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Tfu_1824 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 Tfu_1825 ENOG4105C3R Methionine synthase Tfu_1831 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) Tfu_1832 ENOG4105C8N cysteinyl-tRNA synthetase Tfu_1834 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic Tfu_1837 ENOG4105CVJ phosphoglycerate mutase Tfu_1838 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) Tfu_1839 ENOG4105CPC Aldo Keto reductase Tfu_1841 ENOG4105CHR reductase Tfu_1842 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH Tfu_1843 ENOG4105CHR reductase Tfu_1845 ENOG4105WH1 Two component transcriptional regulator luxr family Tfu_1846 ENOG4105BZU Histidine kinase Tfu_1847 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Tfu_1848 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Tfu_1854 ENOG4105E98 transcriptional regulator DeoR family Tfu_1860 ENOG4105Q26 Siderophore-interacting protein Tfu_1862 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) Tfu_1868 ENOG4105WQI isochorismatase Tfu_1869 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) Tfu_1871 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase Tfu_1872 ENOG4105E4F Isochorismate synthase Tfu_1873 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase Tfu_1875 ENOG4108PJD permease Tfu_1876 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein Tfu_1878 ENOG4105E39 Enoyl-CoA hydratase Tfu_1880 ENOG4105C5H ABC transporter Tfu_1889 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) Tfu_1893 ENOG4105E0X reductase Tfu_1894 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme Tfu_1896 ENOG4107JTW chlorite dismutase Tfu_1897 ENOG4105C1Q protoporphyrinogen oxidase Tfu_1899 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) Tfu_1903 ENOG4105CHU acetyl-coa acetyltransferase Tfu_1912 ENOG4107R13 MMPL domain protein Tfu_1917 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) Tfu_1920 ENOG4107RNG ABC transporter Tfu_1921 ENOG4105C2J ABC transporter Tfu_1922 ENOG4105DFW ABC transporter Tfu_1923 ENOG4105E2R ROK family Tfu_1925 ENOG4107QM5 aconitate hydratase Tfu_1926 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone Tfu_1927 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) Tfu_1928 ENOG4107VEG TrkA-N domain protein Tfu_1930 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone Tfu_1935 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) Tfu_1936 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) Tfu_1940 ENOG4106F60 Histidine kinase Tfu_1941 ENOG4105F44 Two component transcriptional regulator, winged helix family Tfu_1945 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) Tfu_1953 ENOG4105CVJ phosphoglycerate mutase Tfu_1955 ENOG4105EGD dinuclear metal center protein, YbgI family Tfu_1956 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) Tfu_1959 ENOG4105CYP glycoside hydrolase, family Tfu_1961 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Tfu_1966 ENOG4107ZED Uncharacterised protein family UPF0047 Tfu_1968 ENOG4107R7A Allophanate hydrolase subunit 2 Tfu_1969 ENOG4105P4J Allophanate hydrolase, subunit 1 Tfu_1970 ENOG4105E7W lamb ycsf family protein Tfu_1974 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) Tfu_1975 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) Tfu_1976 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) Tfu_1978 ENOG41090WU lipolytic protein G-D-S-L family Tfu_1981 ENOG4105VG1 fes assembly suf system protein Tfu_1982 ENOG4108UNV SUF system FeS assembly protein, NifU family Tfu_1984 ENOG4105C3K feS assembly ATPase SufC Tfu_1989 ENOG4105CJ1 ABC, transporter Tfu_1992 ENOG4105DBV ornithine carbamoyltransferase Tfu_1993 ENOG4105CEU Arginine dihydrolase Tfu_1994 ENOG4107AQZ Membrane Tfu_1998 ENOG4105CEY Amp-dependent synthetase and ligase Tfu_1999 ENOG4105C1G acyl-Coa dehydrogenase Tfu_2000 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) Tfu_2001 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) Tfu_2003 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) Tfu_2004 ENOG4105C89 phosphohexose isomerase Tfu_2007 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) Tfu_2008 ENOG4105CX8 fg-gap repeat protein Tfu_2009 ENOG4105CX8 fg-gap repeat protein Tfu_2011 ENOG4105CUB amino acid Tfu_2015 ENOG4105CP7 Triose-phosphate isomerase Tfu_2016 ENOG4105BZA Phosphoglycerate kinase Tfu_2017 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase Tfu_2018 ENOG4105CIE May be required for sporulation (By similarity) Tfu_2020 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) Tfu_2021 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) Tfu_2024 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) Tfu_2032 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) Tfu_2033 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) Tfu_2038 ENOG4105DSU hydrolase Tfu_2043 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) Tfu_2050 ENOG4105C08 Histidine kinase Tfu_2051 ENOG4105CH7 arginosuccinase Tfu_2052 ENOG4105CDH Citrulline--aspartate ligase Tfu_2053 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) Tfu_2054 ENOG4105C8Y Acetylornithine aminotransferase Tfu_2055 ENOG4105CAS nag kinase Tfu_2056 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) Tfu_2057 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase Tfu_2060 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) Tfu_2061 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) Tfu_2062 ENOG4105BZU Histidine kinase Tfu_2063 ENOG4108RWN rrna methyltransferase Tfu_2064 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) Tfu_2065 ENOG41084BS 50S ribosomal protein L35 Tfu_2066 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) Tfu_2067 ENOG4105E2X shikimate dehydrogenase Tfu_2069 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) Tfu_2070 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) Tfu_2074 ENOG4108762 serine threonine protein kinase Tfu_2075 ENOG4108762 serine threonine protein kinase Tfu_2086 ENOG4105C9M aspartyl-trna synthetase Tfu_2088 ENOG4105C99 atpase involved in dna repair Tfu_2090 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) Tfu_2091 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) Tfu_2093 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) Tfu_2094 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) Tfu_2095 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) Tfu_2096 ENOG4105CDY transcriptional regulatory protein Tfu_2097 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) Tfu_2099 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) Tfu_2101 ENOG4105E2K Glycosyl transferase (Group 1 Tfu_2106 ENOG4105EE5 Membrane protein terC Tfu_2108 ENOG4105C22 threonyL-tRNA synthetase Tfu_2111 ENOG4105KF0 sporulation and cell division protein, SsgA Tfu_2112 ENOG4105CM2 brancheD-chain amino acid aminotransferase Tfu_2113 ENOG4105GWZ Roadblock lc7 family protein Tfu_2114 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family Tfu_2117 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 Tfu_2125 ENOG4105C5X domain protein Tfu_2128 ENOG4105CMV Succinyl-CoA synthetase subunit beta Tfu_2131 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Tfu_2134 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Tfu_2136 ENOG4107XFJ UPF0246 protein Tfu_2139 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Tfu_2143 ENOG4108S0S Nucleotidyl transferase Tfu_2144 ENOG4106F1P AAA ATPase, central domain protein Tfu_2145 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Tfu_2149 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Tfu_2150 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) Tfu_2152 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) Tfu_2156 ENOG4105C8T Leucyl-tRNA synthetase Tfu_2158 ENOG4105CEY Amp-dependent synthetase and ligase Tfu_2160 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase Tfu_2162 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) Tfu_2168 ENOG4108J20 pectate lyase Tfu_2171 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) Tfu_2172 ENOG4105D0M Protease HtpX homolog Tfu_2175 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) Tfu_2176 ENOG4105CYP glycoside hydrolase, family Tfu_2177 ENOG4105CG5 Glycosyl transferase (Group 1 Tfu_2178 ENOG4107SJB teichoic acid biosynthesis Tfu_2179 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) Tfu_2180 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control Tfu_2181 ENOG4105K46 50S ribosomal protein l27 Tfu_2182 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) Tfu_2183 ENOG4105C03 ribonuclease Tfu_2186 ENOG4105CNI cell division protein FtsW Tfu_2188 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) Tfu_2190 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase Tfu_2192 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) Tfu_2193 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Tfu_2194 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Tfu_2195 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation Tfu_2196 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) Tfu_2197 ENOG4105BZ1 (ABC) transporter Tfu_2199 ENOG4105CJW magnesium transporter Tfu_2202 ENOG4108YZG isomerase Tfu_2203 ENOG4105MC2 DSBA oxidoreductase Tfu_2209 ENOG4105C01 Dihydroxy-acid dehydratase Tfu_2214 ENOG4105E5T Major Facilitator Superfamily Tfu_2218 ENOG4105BZU Histidine kinase Tfu_2219 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) Tfu_2221 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) Tfu_2222 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) Tfu_2228 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein Tfu_2232 ENOG4105BZU Histidine kinase Tfu_2233 ENOG4105WH1 Two component transcriptional regulator luxr family Tfu_2234 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) Tfu_2235 ENOG4105P3N Membrane Tfu_2240 ENOG4108XM1 transcriptional regulator AsnC family Tfu_2245 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Tfu_2247 ENOG4105C8Y Acetylornithine aminotransferase Tfu_2250 ENOG4105DWF phosphomethylpyrimidine kinase Tfu_2251 ENOG4105BZG amino acid carrier protein Tfu_2253 ENOG4107QSS Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli (By similarity) Tfu_2254 ENOG4106NZI LysR family Transcriptional regulator Tfu_2257 ENOG4105JNK Glycosyl transferase (Group 1 Tfu_2263 ENOG4105F9U Dehydrogenase Tfu_2269 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) Tfu_2272 ENOG4107QMS site-determining protein Tfu_2278 ENOG4105WH1 Two component transcriptional regulator luxr family Tfu_2281 ENOG41090EK ompa motb domain protein Tfu_2283 ENOG4105K4H Nlp p60 protein Tfu_2288 ENOG4107QJE Chromosome Partitioning Protein Tfu_2293 ENOG4105CPC Aldo Keto reductase Tfu_2300 ENOG4105PGM cation diffusion facilitator family transporter Tfu_2301 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) Tfu_2302 ENOG4105CZN Potassium uptake protein Tfu_2303 ENOG4107ZYR domain protein Tfu_2309 ENOG4105D2B acyl-CoA dehydrogenase Tfu_2310 ENOG4105D2B acyl-CoA dehydrogenase Tfu_2312 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) Tfu_2313 ENOG4108JJB ABC transporter Tfu_2314 ENOG4107ZYJ bioY protein Tfu_2315 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) Tfu_2317 ENOG4105CQ7 ATP-dependent helicase Tfu_2323 ENOG4106KNT transcriptional regulator Tfu_2324 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate Tfu_2325 ENOG4108UB4 uncharacterized protein ygjQ Tfu_2336 ENOG4105G63 Type III effector Hrp-dependent Tfu_2337 ENOG4105EPJ extracellular solute-binding protein family 1 Tfu_2338 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component Tfu_2339 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component Tfu_2341 ENOG4105KJF protein tyrosine phosphatase Tfu_2343 ENOG4105BZU Histidine kinase Tfu_2344 ENOG4105EFQ Two component transcriptional regulator (Winged helix family Tfu_2345 ENOG4105EWN Heme oxygenase Tfu_2350 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) Tfu_2351 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) Tfu_2352 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) Tfu_2353 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) Tfu_2361 ENOG4105D9P serine threonine protein kinase Tfu_2363 ENOG4107VK2 coenzyme PQQ biosynthesis protein PqqF Tfu_2364 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) Tfu_2365 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) Tfu_2372 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) Tfu_2374 ENOG4108RWI nicotinamidase Tfu_2376 ENOG4105C31 Tryptophanyl-tRNA synthetase Tfu_2384 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) Tfu_2385 ENOG4105EHG Permease protein Tfu_2389 ENOG4108UJU UPF0301 protein Tfu_2394 ENOG4105CHU acetyl-coa acetyltransferase Tfu_2395 ENOG4108ZVT methylmalonyl-coA epimerase Tfu_2401 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) Tfu_2406 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) Tfu_2407 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) Tfu_2408 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) Tfu_2409 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) Tfu_2410 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) Tfu_2411 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) Tfu_2412 ENOG4105ZA1 atp synthase Tfu_2416 ENOG4105ESV Glycosyl transferase, family 4 Tfu_2418 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) Tfu_2419 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) Tfu_2420 ENOG4105VFB Binds the 23S rRNA (By similarity) Tfu_2422 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) Tfu_2423 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) Tfu_2424 ENOG4105D6E homoserine dehydrogenase Tfu_2425 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) Tfu_2427 ENOG4105EBR Carboxylesterase Tfu_2433 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) Tfu_2450 ENOG4105CFI type iii restriction protein res subunit Tfu_2451 ENOG4105E33 succinate dehydrogenase Tfu_2454 ENOG4105C5Q Transcriptional regulator Tfu_2455 ENOG41061H0 Monooxygenase Tfu_2456 ENOG4105CI3 gtp-binding protein typa Tfu_2457 ENOG4105M6F mutator MutT protein Tfu_2461 ENOG4105IQ5 FAD linked oxidase domain protein Tfu_2462 ENOG4108RG3 short-chain dehydrogenase reductase Tfu_2464 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) Tfu_2465 ENOG4108M6P methyltransferase Tfu_2467 ENOG41073B4 coagulation factor 5 8 type domain-containing protein Tfu_2473 ENOG4105CE4 GlcNAc 6-P deacetylase Tfu_2476 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) Tfu_2477 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) Tfu_2478 ENOG4105CAK Cell division ATP-binding protein ftsE Tfu_2479 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) Tfu_2481 ENOG4105C7I Dehydrogenase Tfu_2484 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 Tfu_2485 ENOG4105C1G acyl-Coa dehydrogenase Tfu_2486 ENOG4105D17 glycoside hydrolase, family 3 domain protein Tfu_2487 ENOG4105KZ7 phosphocarrier protein hpr Tfu_2489 ENOG4105C5Y PTS System Tfu_2490 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving Tfu_2491 ENOG4105WH1 Two component transcriptional regulator luxr family Tfu_2492 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea Tfu_2493 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) Tfu_2494 ENOG4105G3P Lipoprotein lpqB Tfu_2495 ENOG4105BZU Histidine kinase Tfu_2496 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Tfu_2499 ENOG4108WQ6 secreted protein Tfu_2500 ENOG4105C7R Atpase associated with various cellular activities aaa_3 Tfu_2505 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) Tfu_2509 ENOG4105W49 UPF0434 protein Tfu_2514 ENOG4107RGC Glycosyl transferase, family 2 Tfu_2515 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) Tfu_2517 ENOG4105EIH LPPG Fo 2-phospho-L-lactate transferase Tfu_2518 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) Tfu_2519 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) Tfu_2520 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Tfu_2522 ENOG4107Y2G Glycosyl transferase (Group 1 Tfu_2526 ENOG4108KGH TRANSCRIPTIONal Tfu_2529 ENOG4107QQG Dehydrogenase Tfu_2530 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) Tfu_2533 ENOG4105D49 3-dehydroquinate synthase Tfu_2537 ENOG4105EY8 ABC transporter Tfu_2539 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) Tfu_2542 ENOG4108KGH TRANSCRIPTIONal Tfu_2544 ENOG4105C6Y Udp-glucose 6-dehydrogenase Tfu_2545 ENOG4105K4P CoA-binding domain protein Tfu_2546 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) Tfu_2549 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Tfu_2550 ENOG41065SU Two-component system sensor kinase Tfu_2552 ENOG4108QER Adenylate cyclase Tfu_2553 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase Tfu_2554 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) Tfu_2555 ENOG4105D8K carboxyl transferase Tfu_2557 ENOG4108JIK carboxylase Tfu_2563 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) Tfu_2564 ENOG4107RM1 amidohydrolase Tfu_2565 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) Tfu_2567 ENOG4108KGH TRANSCRIPTIONal Tfu_2571 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) Tfu_2572 ENOG4105DC1 bifunctional purine biosynthesis protein purh Tfu_2577 ENOG4105CMV Succinyl-CoA synthetase subunit beta Tfu_2582 ENOG4105WH1 Two component transcriptional regulator luxr family Tfu_2583 ENOG4105BZU Histidine kinase Tfu_2589 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) Tfu_2590 ENOG4105C26 Dehydrogenase Tfu_2591 ENOG4105CMR udp-glucose 4-epimerase Tfu_2592 ENOG4107S1Q Phosphatase Tfu_2593 ENOG4105C6V Glycerol-3-phosphate dehydrogenase Tfu_2595 ENOG4107QVP Dehydrogenase Tfu_2597 ENOG4108MMM RNA Polymerase Tfu_2598 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) Tfu_2599 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) Tfu_2602 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Tfu_2603 ENOG4108Z7F N-acetyltransferase Tfu_2605 ENOG4108097 ATP-binding protein Tfu_2606 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) Tfu_2610 ENOG4105CS9 pantothenic acid kinase Tfu_2611 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) Tfu_2612 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) Tfu_2613 ENOG4108UJD 30S ribosomal protein S9 Tfu_2614 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) Tfu_2616 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) Tfu_2617 ENOG4108ZT0 50S ribosomal protein l17 Tfu_2618 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Tfu_2619 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) Tfu_2620 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits Tfu_2621 ENOG41067V7 50S ribosomal protein L36 Tfu_2622 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) Tfu_2624 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) Tfu_2625 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) Tfu_2627 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) Tfu_2628 ENOG410849U 50S ribosomal protein L30 Tfu_2629 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) Tfu_2630 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) Tfu_2631 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) Tfu_2632 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) Tfu_2633 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) Tfu_2634 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits Tfu_2635 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) Tfu_2636 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) Tfu_2637 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal Tfu_2638 ENOG41082SA 50s ribosomal protein l29 Tfu_2639 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) Tfu_2640 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) Tfu_2641 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) Tfu_2642 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) Tfu_2643 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity Tfu_2644 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) Tfu_2645 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) Tfu_2646 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) Tfu_2647 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) Tfu_2648 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) Tfu_2649 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) Tfu_2650 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) Tfu_2651 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) Tfu_2653 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Tfu_2654 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Tfu_2655 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) Tfu_2656 ENOG4108VZM 50s ribosomal protein L10 Tfu_2657 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) Tfu_2658 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) Tfu_2662 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) Tfu_2664 ENOG4107R4N Cell wall formation (By similarity) Tfu_2666 ENOG410900P UPF0336 protein Tfu_2667 ENOG4105WDJ 50S ribosomal protein L33 Tfu_2668 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) Tfu_2672 ENOG4108VPT UPF0234 protein Tfu_2673 ENOG4105D0M Protease HtpX homolog Tfu_2674 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein Tfu_2675 ENOG4105DQU oxidoreductase, subunit beta Tfu_2678 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) Tfu_2682 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Tfu_2685 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Tfu_2686 ENOG4105DF2 NADH dehydrogenase subunit j Tfu_2687 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Tfu_2688 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) Tfu_2689 ENOG4108IEH NADH dehydrogenase subunit g Tfu_2690 ENOG4107QIZ NADH dehydrogenase Tfu_2692 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Tfu_2693 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain Tfu_2694 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Tfu_2697 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Tfu_2701 ENOG4105CRE cytochrome C Tfu_2702 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) Tfu_2703 ENOG4107QIV Cytochrome c biogenesis protein Tfu_2704 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Tfu_2706 ENOG4108XFF Tfu_2707 ENOG4105DGU Histone deacetylase Tfu_2709 ENOG4105EY0 Xylose isomerase domain protein TIM barrel Tfu_2711 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) Tfu_2712 ENOG4106R7G Glycoside hydrolase family 5 Tfu_2714 ENOG4105DMS mur ligase Tfu_2719 ENOG4105KHC sulfurtransferase Tfu_2722 ENOG4108RXW HAD-superfamily subfamily IB hydrolase Tfu_2725 ENOG4108RH7 phosphoglycerate mutase Tfu_2726 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase Tfu_2727 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) Tfu_2730 ENOG4105D52 delta-aminolevulinic acid dehydratase Tfu_2732 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) Tfu_2733 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) Tfu_2734 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) Tfu_2737 ENOG4107NHD transcriptional regulator Tfu_2739 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) Tfu_2740 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) Tfu_2743 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) Tfu_2744 ENOG4105CJ3 phosphate transporter Tfu_2748 ENOG4105CXB phosphoribosylaminoimidazole synthetase Tfu_2750 ENOG4108TAC Tfu_2755 ENOG4108IG5 Transcriptional regulator Tfu_2757 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein Tfu_2759 ENOG4108V06 Glutathione peroxidase Tfu_2765 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) Tfu_2768 ENOG4105F8D glycoside hydrolase family 4 Tfu_2770 ENOG41080RH Thioredoxin Tfu_2771 ENOG4107QPD alcohol dehydrogenase Tfu_2781 ENOG4105MA4 psp1 domain protein Tfu_2783 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) Tfu_2784 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) Tfu_2787 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) Tfu_2788 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) Tfu_2790 ENOG4105ETE Transcriptional regulator (LacI family Tfu_2791 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) Tfu_2797 ENOG4105MWK D-amino acid dehydrogenase, small subunit Tfu_2798 ENOG4108K8K Transcriptional regulator Tfu_2811 ENOG4105D5P Methylmalonyl-coA mutase Tfu_2814 ENOG4105CPQ Dehydrogenase Tfu_2815 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) Tfu_2816 ENOG4108IG5 Transcriptional regulator Tfu_2817 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) Tfu_2822 ENOG4105DWV Homoserine O-trans-acetylase Tfu_2828 ENOG4108Z0Z intracellular protease Pfpi family Tfu_2830 ENOG4108X07 Tetr family transcriptional regulator Tfu_2834 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) Tfu_2841 ENOG4107SCK Monooxygenase Tfu_2855 ENOG41067S9 phage shock protein C, PspC Tfu_2856 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Tfu_2857 ENOG4108HRK Histidine kinase Tfu_2858 ENOG4105DY9 regulatoR Tfu_2862 ENOG4107QN1 sodium solute Tfu_2872 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands Tfu_2873 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) Tfu_2876 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Tfu_2878 ENOG4105C4R Atp-dependent dna helicase Tfu_2881 ENOG4105CRK lysyL-tRNA synthetase Tfu_2882 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) Tfu_2883 ENOG4108IYU L-aspartate oxidase Tfu_2884 ENOG4107QQT Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) Tfu_2893 ENOG4105EEI dihydropteroate synthase Tfu_2894 ENOG4105EUJ GTP cyclohydrolase i Tfu_2896 ENOG4108UGV hypoxanthine phosphoribosyltransferase Tfu_2897 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) Tfu_2902 ENOG4105F0N pyrophosphate phospho-hydrolase Tfu_2906 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) Tfu_2907 ENOG4108VJ1 Transcriptional regulator (CarD family Tfu_2909 ENOG4105BZU Histidine kinase Tfu_2911 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) Tfu_2913 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) Tfu_2922 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) Tfu_2923 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) Tfu_2930 ENOG4108IJ7 Glycine betaine Tfu_2932 ENOG4105DHP deoxycytidine triphosphate deaminase Tfu_2941 ENOG4105FDP GntR family transcriptional regulator Tfu_2948 ENOG4105VTR Integrase Tfu_2953 ENOG4105DWF phosphomethylpyrimidine kinase Tfu_2956 ENOG4108KGH TRANSCRIPTIONal Tfu_2960 ENOG41062D9 Histidine kinase Tfu_2970 ENOG4107QRI Phosphoketolase Tfu_2971 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) Tfu_2975 ENOG4106A3M Cytochrome p-450 Tfu_2976 ENOG4106A3M Cytochrome p-450 Tfu_2990 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) Tfu_2995 ENOG4105CHF Glutathione S-transferase Tfu_3001 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Tfu_3002 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Tfu_3003 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) Tfu_3007 ENOG4105VF7 tolerance protein Tfu_3008 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) Tfu_3012 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis Tfu_3013 ENOG4105C12 Phosphoribosylglycinamide synthetase Tfu_3015 ENOG4105C8V SAICAR synthetase Tfu_3016 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) Tfu_3018 ENOG4105CIH Imidazole acetol-phosphate transaminase Tfu_3022 ENOG4105NAF rna polymerase sigma factor Tfu_3025 ENOG4105E2A Dehydrogenase Tfu_3029 ENOG4108BFU camphor resistance protein CrcB Tfu_3030 ENOG41083YR Protein CrcB homolog Tfu_3032 ENOG4108YV4 Universal stress protein Tfu_3043 ENOG4107UVD Beta-phosphoglucomutase family hydrolase Tfu_3049 ENOG4108JYK Dehydrogenase Tfu_3051 ENOG4105C7S Dehydrogenase Tfu_3053 ENOG4105CQC Prephenate dehydratase Tfu_3054 ENOG4105CKK Glycosyl transferase, family 2 Tfu_3055 ENOG41082AN stage II sporulation protein Tfu_3058 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) Tfu_3061 ENOG4105HZM Fha domain containing protein Tfu_3062 ENOG4108ZF3 Phosphatase Tfu_3064 ENOG4105CJN penicillin-binding protein Tfu_3065 ENOG4107TPY serine threonine protein kinase Tfu_3078 ENOG4105DBE peroxidase Tfu_3085 ENOG4105C5X domain protein Tfu_3089 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Tfu_3090 ENOG4105CVN desaturase Tfu_3092 ENOG4105K9Q Binds to the 23S rRNA (By similarity) Tfu_3093 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) Tfu_3094 ENOG4107YH6 single-stranded DNA-binding protein Tfu_3095 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) Tfu_3097 ENOG4105BZ4 penicillin-binding protein Tfu_3105 ENOG4105D9P serine threonine protein kinase Tfu_3108 ENOG4105C3M thioredoxin reductase Tfu_3109 ENOG4105K63 Thioredoxin Tfu_3111 ENOG4107QJE Chromosome Partitioning Protein Tfu_3112 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) Tfu_3114 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins Tfu_3115 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) Tfu_3116 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) Tfu_3117 ENOG41084CH 50S ribosomal protein l34