locus-tag	class	description
NI17_000005	COG2329	Antibiotic biosynthesis monooxygenase
NI17_000010	COG5297	Belongs to the glycosyl hydrolase family 6
NI17_000015	COG0179	Fumarylacetoacetate (FAA) hydrolase
NI17_000020	COG2311	Membrane
NI17_000025	COG1725	Transcriptional regulator
NI17_000030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NI17_000050	COG2133	pyrroloquinoline quinone binding
NI17_000055	COG1414	Transcriptional regulator
NI17_000060	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NI17_000065	COG0066	3-isopropylmalate dehydratase activity
NI17_000080	COG1920	GTP binding
NI17_000090	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NI17_000100	COG1181	Belongs to the D-alanine--D-alanine ligase family
NI17_000115	COG4988	ABC transporter
NI17_000120	COG1294	oxidase, subunit
NI17_000125	COG1271	oxidase subunit
NI17_000160	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NI17_000170	COG0742	ribosomal rna small subunit methyltransferase
NI17_000175	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NI17_000185	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NI17_000190	COG0571	ribonuclease III activity
NI17_000195	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NI17_000200	COG1254	Belongs to the acylphosphatase family
NI17_000215	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NI17_000220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NI17_000225	COG0552	protein localization to endoplasmic reticulum
NI17_000240	COG1131	(ABC) transporter
NI17_000260	COG0228	four-way junction DNA binding
NI17_000265	COG1837	Belongs to the UPF0109 family
NI17_000270	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NI17_000275	COG0336	Belongs to the RNA methyltransferase TrmD family
NI17_000280	COG0335	large ribosomal subunit rRNA binding
NI17_000300	COG0792	nuclease activity
NI17_000320	COG4974	Belongs to the 'phage' integrase family
NI17_000330	COG0052	Belongs to the universal ribosomal protein uS2 family
NI17_000335	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NI17_000340	COG0528	UMP kinase activity
NI17_000345	COG0233	cytoplasmic translational termination
NI17_000365	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NI17_000375	COG1522	sequence-specific DNA binding
NI17_000385	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NI17_000450	COG1105	Belongs to the carbohydrate kinase PfkB family
NI17_000460	COG1028	Short-chain dehydrogenase reductase Sdr
NI17_000540	COG1201	RNA secondary structure unwinding
NI17_000630	COG0210	DNA helicase
NI17_000685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NI17_000700	COG1132	(ABC) transporter
NI17_000710	COG2226	methyltransferase
NI17_000715	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NI17_000725	COG0583	DNA-binding transcription factor activity
NI17_000755	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NI17_000775	COG2885	chlorophyll binding
NI17_000785	COG1012	belongs to the aldehyde dehydrogenase family
NI17_000815	COG0750	zinc metalloprotease
NI17_000820	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NI17_000825	COG0596	Alpha beta hydrolase
NI17_000875	COG0124	histidyl-tRNA synthetase
NI17_000895	COG0653	protein targeting
NI17_000925	COG1271	oxidase subunit
NI17_000930	COG2197	response regulator
NI17_000935	COG4585	Histidine kinase
NI17_000955	COG0442	prolyl-tRNA aminoacylation
NI17_000970	COG0779	Required for maturation of 30S ribosomal subunits
NI17_000985	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NI17_000995	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NI17_001000	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NI17_001010	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NI17_001015	COG1185	polyribonucleotide nucleotidyltransferase activity
NI17_001020	COG0612	Peptidase, M16
NI17_001025	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NI17_001030	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NI17_001045	COG1950	PFAM Membrane protein of
NI17_001050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NI17_001055	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NI17_001060	COG1674	ftsk spoiiie
NI17_001070	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NI17_001080	COG1546	Belongs to the CinA family
NI17_001080	COG1058	Belongs to the CinA family
NI17_001085	COG1396	sequence-specific DNA binding
NI17_001090	COG0783	Belongs to the Dps family
NI17_001110	COG1372	Participates in initiation and elongation during chromosome replication
NI17_001110	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NI17_001110	COG1372	Participates in initiation and elongation during chromosome replication
NI17_001110	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NI17_001115	COG2137	regulation of response to DNA damage stimulus
NI17_001120	COG1566	PFAM secretion protein HlyD family protein
NI17_001120	COG1418	mRNA catabolic process
NI17_001125	COG1505	serine-type exopeptidase activity
NI17_001130	COG0765	amino acid transport
NI17_001135	COG0765	amino acid transport
NI17_001140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NI17_001145	COG1126	abc transporter atp-binding protein
NI17_001150	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NI17_001180	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NI17_001185	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NI17_001205	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NI17_001210	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NI17_001215	COG1228	amidohydrolase
NI17_001245	COG0268	Binds directly to 16S ribosomal RNA
NI17_001255	COG0481	GTPase activity
NI17_001260	COG3833	ABC-type maltose transport systems, permease component
NI17_001265	COG1175	transmembrane transport
NI17_001275	COG0366	Alpha amylase catalytic
NI17_001285	COG2258	MOSC domain
NI17_001310	COG1420	regulation of RNA biosynthetic process
NI17_001315	COG0484	heat shock protein binding
NI17_001335	COG0537	adenosine 5'-monophosphoramidase activity
NI17_001345	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NI17_001360	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NI17_001365	COG1414	Transcriptional regulator
NI17_001385	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NI17_001390	COG2340	Cysteine-rich secretory protein family
NI17_001395	COG1381	Involved in DNA repair and RecF pathway recombination
NI17_001400	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NI17_001420	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NI17_001425	COG1121	(ABC) transporter
NI17_001440	COG0423	glycine-tRNA ligase activity
NI17_001450	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NI17_001450	COG0574	Belongs to the PEP-utilizing enzyme family
NI17_001460	COG0232	Belongs to the dGTPase family. Type 2 subfamily
NI17_001470	COG0358	DNA primase activity
NI17_001475	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NI17_001520	COG0659	secondary active sulfate transmembrane transporter activity
NI17_001530	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NI17_001535	COG0596	Alpha beta hydrolase
NI17_001540	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NI17_001545	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NI17_001550	COG3485	protocatechuate 3,4-dioxygenase
NI17_001555	COG3485	protocatechuate 3,4-dioxygenase
NI17_001560	COG0183	Belongs to the thiolase family
NI17_001565	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NI17_001570	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NI17_001575	COG1414	Transcriptional regulator
NI17_001580	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NI17_001630	COG2814	Major facilitator Superfamily
NI17_001635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NI17_001645	COG0702	epimerase
NI17_001655	COG1846	Transcriptional regulator
NI17_001660	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NI17_001685	COG3546	catalase activity
NI17_001700	COG0300	oxidoreductase activity
NI17_001735	COG0859	PFAM glycosyl transferase family 9
NI17_001750	COG2192	nodulation
NI17_001770	COG0438	transferase activity, transferring glycosyl groups
NI17_001775	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NI17_001780	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
NI17_001780	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NI17_001785	COG1028	Short-chain dehydrogenase reductase Sdr
NI17_001790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NI17_001850	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NI17_001875	COG1349	DNA-binding transcription factor activity
NI17_001885	COG1609	Transcriptional regulator
NI17_001895	COG0601	transmembrane transport
NI17_001900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NI17_001905	COG0444	Belongs to the ABC transporter superfamily
NI17_001935	COG4585	Histidine kinase
NI17_001975	COG1522	sequence-specific DNA binding
NI17_001980	COG3483	tryptophan 2,3-dioxygenase activity
NI17_002010	COG1476	TRANSCRIPTIONal
NI17_002040	COG0167	dihydroorotate dehydrogenase activity
NI17_002080	COG0395	ABC-type sugar transport system, permease component
NI17_002085	COG2723	6-phospho-beta-galactosidase activity
NI17_002100	COG4191	Histidine kinase
NI17_002105	COG2018	Roadblock/LC7 domain
NI17_002120	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NI17_002135	COG1960	acyl-CoA dehydrogenase activity
NI17_002145	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NI17_002155	COG1252	NADH dehydrogenase
NI17_002165	COG1937	Protein conserved in bacteria
NI17_002220	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NI17_002225	COG3336	cytochrome c oxidase
NI17_002290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NI17_002295	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NI17_002300	COG0174	glutamine synthetase
NI17_002305	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NI17_002305	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NI17_002320	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
NI17_002345	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NI17_002350	COG0321	lipoyl(octanoyl) transferase activity
NI17_002355	COG0508	dehydrogenase complex catalyzes the overall conversion of
NI17_002360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NI17_002365	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NI17_002370	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
NI17_002375	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
NI17_002385	COG4717	serine-type aminopeptidase activity
NI17_002390	COG0420	3'-5' exonuclease activity
NI17_002400	COG0667	Aldo Keto reductase
NI17_002420	COG0501	Belongs to the peptidase M48B family
NI17_002430	COG1929	Belongs to the glycerate kinase type-1 family
NI17_002440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NI17_002445	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NI17_002460	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NI17_002470	COG1376	ErfK ybiS ycfS ynhG family protein
NI17_002475	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NI17_002480	COG0723	plastoquinol--plastocyanin reductase activity
NI17_002490	COG1845	cytochrome c oxidase, subunit III
NI17_002500	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NI17_002535	COG1022	Amp-dependent synthetase and ligase
NI17_002545	COG1940	carbohydrate kinase activity
NI17_002575	COG0301	tRNA thio-modification
NI17_002580	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
NI17_002585	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NI17_002590	COG2815	serine threonine protein kinase
NI17_002590	COG0515	serine threonine protein kinase
NI17_002595	COG2022	thiamine diphosphate biosynthetic process
NI17_002605	COG2022	thiamine diphosphate biosynthetic process
NI17_002605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NI17_002615	COG0352	thiamine-phosphate diphosphorylase activity
NI17_002640	COG0142	geranyltranstransferase activity
NI17_002655	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
NI17_002660	COG0540	Belongs to the ATCase OTCase family
NI17_002665	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NI17_002670	COG0505	Belongs to the CarA family
NI17_002675	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NI17_002680	COG0543	2 iron, 2 sulfur cluster binding
NI17_002685	COG0167	dihydroorotate dehydrogenase activity
NI17_002690	COG0284	orotidine-5'-phosphate decarboxylase activity
NI17_002700	COG0194	GDP metabolic process
NI17_002705	COG1758	RNA polymerase activity
NI17_002715	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NI17_002720	COG2311	Membrane
NI17_002740	COG1960	acyl-CoA dehydrogenase activity
NI17_002765	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NI17_002780	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NI17_002790	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NI17_002800	COG3201	nicotinamide mononucleotide transporter
NI17_002805	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NI17_002805	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NI17_002810	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NI17_002820	COG2017	converts alpha-aldose to the beta-anomer
NI17_002825	COG2815	serine threonine protein kinase
NI17_002825	COG0515	serine threonine protein kinase
NI17_002855	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NI17_002860	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NI17_002865	COG0419	ATPase involved in DNA repair
NI17_002875	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NI17_002880	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NI17_002885	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NI17_002895	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NI17_002915	COG0714	Associated with various cellular activities
NI17_002920	COG2001	Belongs to the MraZ family
NI17_002925	COG0275	rRNA processing
NI17_002935	COG0768	penicillin binding
NI17_002940	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NI17_002950	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NI17_002955	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NI17_002965	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NI17_002970	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NI17_002975	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NI17_002980	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NI17_002985	COG1496	oxidoreductase activity
NI17_002990	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NI17_002995	COG1799	cell septum assembly
NI17_003005	COG3599	regulation of cell shape
NI17_003015	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NI17_003025	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NI17_003035	COG1309	transcriptional regulator
NI17_003090	COG2318	DinB family
NI17_003135	COG2153	protein acetylation
NI17_003145	COG0477	Major facilitator Superfamily
NI17_003160	COG1132	(ABC) transporter
NI17_003190	COG1695	Transcriptional regulator
NI17_003200	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NI17_003210	COG1528	Iron-storage protein
NI17_003215	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NI17_003220	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NI17_003225	COG0131	Imidazoleglycerol-phosphate dehydratase
NI17_003235	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NI17_003240	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NI17_003245	COG0107	imidazoleglycerol-phosphate synthase activity
NI17_003255	COG1132	(ABC) transporter
NI17_003265	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NI17_003290	COG0134	indole-3-glycerol-phosphate synthase activity
NI17_003295	COG0133	tryptophan synthase activity
NI17_003300	COG0159	tryptophan synthase activity
NI17_003315	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NI17_003335	COG0067	glutamate synthase
NI17_003335	COG0069	glutamate synthase activity
NI17_003335	COG0070	glutamate synthase
NI17_003360	COG0693	protein deglycase activity
NI17_003420	COG2050	protein possibly involved in aromatic compounds catabolism
NI17_003430	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
NI17_003435	COG0539	negative regulation of cytoplasmic translation
NI17_003440	COG0237	dephospho-CoA kinase activity
NI17_003445	COG0556	nucleotide-excision repair
NI17_003460	COG0504	CTP synthase activity
NI17_003485	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NI17_003490	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NI17_003510	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NI17_003515	COG1160	GTP binding
NI17_003535	COG1733	regulation of RNA biosynthetic process
NI17_003540	COG1683	Conserved Protein
NI17_003560	COG0395	ABC-type sugar transport system, permease component
NI17_003575	COG1609	Transcriptional regulator
NI17_003580	COG2233	PERMEase
NI17_003585	COG0483	inositol monophosphate 1-phosphatase activity
NI17_003610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NI17_003620	COG2814	Major facilitator Superfamily
NI17_003640	COG0463	Glycosyl transferase, family 2
NI17_003650	COG0463	Glycosyl transferase, family 2
NI17_003655	COG2814	Major facilitator Superfamily
NI17_003660	COG0561	phosphatase activity
NI17_003665	COG0242	peptide deformylase activity
NI17_003685	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NI17_003720	COG0673	inositol 2-dehydrogenase activity
NI17_003735	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NI17_003740	COG4948	Mandelate Racemase Muconate Lactonizing
NI17_003745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NI17_003745	COG0723	plastoquinol--plastocyanin reductase activity
NI17_003750	COG1609	Transcriptional regulator
NI17_003770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NI17_003790	COG0747	negative chemotaxis
NI17_003795	COG0601	transmembrane transport
NI17_003800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NI17_003805	COG4608	Belongs to the ABC transporter superfamily
NI17_003825	COG1609	Transcriptional regulator
NI17_003850	COG0673	inositol 2-dehydrogenase activity
NI17_003855	COG1175	transmembrane transport
NI17_003860	COG0395	ABC-type sugar transport system, permease component
NI17_003865	COG1653	transport
NI17_003870	COG2755	lipolytic protein G-D-S-L family
NI17_003870	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NI17_003875	COG1028	Short-chain dehydrogenase reductase Sdr
NI17_003880	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NI17_003885	COG2072	flavoprotein involved in K transport
NI17_003895	COG1132	(ABC) transporter
NI17_003910	COG2226	methyltransferase
NI17_003940	COG0243	molybdopterin cofactor binding
NI17_003950	COG2111	Na H antiporter
NI17_003950	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NI17_003955	COG2111	Na H antiporter
NI17_003960	COG1006	Multisubunit Na H antiporter MnhC subunit
NI17_003965	COG0651	ATP synthesis coupled electron transport
NI17_003970	COG1320	monovalent cation:proton antiporter activity
NI17_003975	COG0028	Belongs to the TPP enzyme family
NI17_003980	COG0277	FAD linked oxidase domain protein
NI17_003980	COG0247	lactate metabolic process
NI17_003990	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NI17_004010	COG0110	maltose O-acetyltransferase activity
NI17_004075	COG1253	flavin adenine dinucleotide binding
NI17_004080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NI17_004085	COG2813	Specifically methylates the guanine in position
NI17_004090	COG1028	Short-chain dehydrogenase reductase Sdr
NI17_004110	COG2304	oxidoreductase activity
NI17_004120	COG0714	Associated with various cellular activities
NI17_004130	COG0667	Aldo Keto reductase
NI17_004135	COG3540	Alkaline phosphatase
NI17_004150	COG3842	ATPase activity
NI17_004160	COG2239	Acts as a magnesium transporter
NI17_004185	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NI17_004215	COG1162	GTPase activity
NI17_004225	COG2885	chlorophyll binding
NI17_004235	COG2205	protein histidine kinase activity
NI17_004260	COG2267	carboxylic ester hydrolase activity
NI17_004280	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NI17_004300	COG1357	PFAM Pentapeptide repeats (8 copies)
NI17_004305	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NI17_004310	COG0515	serine threonine protein kinase
NI17_004310	COG2815	serine threonine protein kinase
NI17_004325	COG1285	pathogenesis
NI17_004330	COG3387	PFAM Glycoside hydrolase 15-related
NI17_004335	COG2364	Membrane
NI17_004340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NI17_004345	COG2267	carboxylic ester hydrolase activity
NI17_004350	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NI17_004360	COG0515	serine threonine protein kinase
NI17_004360	COG2815	serine threonine protein kinase
NI17_004370	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
NI17_004470	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NI17_004485	COG1690	Belongs to the RtcB family
NI17_004510	COG0746	molybdenum cofactor guanylyltransferase activity
NI17_004535	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NI17_004540	COG1316	TRANSCRIPTIONal
NI17_004550	COG1131	(ABC) transporter
NI17_004565	COG2186	Transcriptional regulator
NI17_004570	COG2807	transmembrane transport
NI17_004590	COG1960	acyl-CoA dehydrogenase activity
NI17_004615	COG0789	Transcriptional regulator
NI17_004655	COG1966	Carbon starvation protein
NI17_004665	COG0003	Pfam Anion-transporting ATPase
NI17_004680	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NI17_004700	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NI17_004700	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NI17_004730	COG1476	TRANSCRIPTIONal
NI17_004735	COG1515	deoxyribonuclease V activity
NI17_004745	COG4585	Histidine kinase
NI17_004750	COG2197	response regulator
NI17_004775	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NI17_004785	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
NI17_004790	COG4948	Mandelate Racemase Muconate Lactonizing
NI17_004795	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
NI17_004810	COG1649	PFAM Uncharacterised BCR, COG1649
NI17_004840	COG1289	transmembrane transporter activity
NI17_004880	COG0789	Transcriptional regulator
NI17_004885	COG5006	permease, DMT superfamily
NI17_004905	COG0598	Magnesium transport protein CorA
NI17_004910	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NI17_004915	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NI17_004920	COG0318	PFAM AMP-dependent synthetase and ligase
NI17_005005	COG0028	Belongs to the TPP enzyme family
NI17_005025	COG1176	ABC-type spermidine putrescine transport system, permease component I
NI17_005035	COG3842	ATPase activity
NI17_005070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NI17_005095	COG0515	serine threonine protein kinase
NI17_005145	COG3903	Transcriptional regulator
NI17_005145	COG3629	intracellular signal transduction
NI17_005160	COG1403	HNH endonuclease
NI17_005165	COG0513	Belongs to the DEAD box helicase family
NI17_005185	COG2318	DinB family
NI17_005195	COG1309	transcriptional regulator
NI17_005210	COG0517	IMP dehydrogenase activity
NI17_005210	COG1994	Peptidase M50
NI17_005260	COG1131	(ABC) transporter
NI17_005270	COG1309	transcriptional regulator
NI17_005290	COG0596	Alpha beta hydrolase
NI17_005300	COG2365	Tyrosine phosphatase family
NI17_005305	COG2271	Major facilitator Superfamily
NI17_005335	COG1902	pentaerythritol trinitrate reductase activity
NI17_005355	COG0714	Associated with various cellular activities
NI17_005365	COG3552	Protein containing von Willebrand factor type A (VWA) domain
NI17_005375	COG2208	phosphoserine phosphatase activity
NI17_005380	COG0596	Alpha beta hydrolase
NI17_005395	COG2197	response regulator
NI17_005400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NI17_005410	COG1169	isochorismate synthase
NI17_005415	COG3433	isochorismatase activity
NI17_005415	COG1535	isochorismatase
NI17_005435	COG2226	methyltransferase
NI17_005435	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NI17_005435	COG3433	isochorismatase activity
NI17_005460	COG1132	(ABC) transporter
NI17_005460	COG2375	cellular response to nickel ion
NI17_005480	COG4166	transmembrane transport
NI17_005485	COG0601	transmembrane transport
NI17_005490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NI17_005505	COG3458	cephalosporin-C deacetylase activity
NI17_005530	COG0582	viral genome integration into host DNA
NI17_005600	COG1012	belongs to the aldehyde dehydrogenase family
NI17_005625	COG1960	acyl-CoA dehydrogenase activity
NI17_005630	COG2070	2-Nitropropane dioxygenase
NI17_005645	COG1028	Short-chain dehydrogenase reductase Sdr
NI17_005655	COG1028	Short-chain dehydrogenase reductase Sdr
NI17_005670	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
NI17_005690	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NI17_005720	COG0657	acetylesterase activity
NI17_005725	COG1902	pentaerythritol trinitrate reductase activity
NI17_005725	COG0446	pyridine nucleotide-disulphide oxidoreductase
NI17_005730	COG2072	flavoprotein involved in K transport
NI17_005765	COG1302	Protein conserved in bacteria
NI17_005775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NI17_005780	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NI17_005785	COG1120	ATPase activity
NI17_005805	COG1404	Belongs to the peptidase S8 family
NI17_005820	COG1309	transcriptional regulator
NI17_005860	COG2267	carboxylic ester hydrolase activity
NI17_005870	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NI17_005885	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NI17_005925	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NI17_005935	COG1028	Short-chain dehydrogenase reductase Sdr
NI17_005945	COG2814	Major facilitator Superfamily
NI17_005995	COG0671	phosphoesterase, PA-phosphatase related
NI17_006000	COG2267	carboxylic ester hydrolase activity
NI17_006010	COG1028	Short-chain dehydrogenase reductase Sdr
NI17_006040	COG4948	Mandelate Racemase Muconate Lactonizing
NI17_006060	COG3118	belongs to the thioredoxin family
NI17_006070	COG1028	Short-chain dehydrogenase reductase Sdr
NI17_006075	COG1132	(ABC) transporter
NI17_006090	COG1120	ATPase activity
NI17_006095	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NI17_006100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NI17_006170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NI17_006205	COG0789	Transcriptional regulator
NI17_006215	COG1028	Short-chain dehydrogenase reductase Sdr
NI17_006225	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NI17_006255	COG0601	transmembrane transport
NI17_006275	COG2723	6-phospho-beta-galactosidase activity
NI17_006285	COG1802	Transcriptional regulator
NI17_006290	COG5006	permease, DMT superfamily
NI17_006320	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NI17_006335	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NI17_006340	COG0726	polysaccharide deacetylase
NI17_006345	COG0740	serine-type endopeptidase activity
NI17_006350	COG1396	sequence-specific DNA binding
NI17_006355	COG1609	Transcriptional regulator
NI17_006360	COG1653	transport
NI17_006365	COG1175	transmembrane transport
NI17_006395	COG1501	Belongs to the glycosyl hydrolase 31 family
NI17_006420	COG0395	ABC-type sugar transport system, permease component
NI17_006425	COG4209	transmembrane transport
NI17_006435	COG1940	carbohydrate kinase activity
NI17_006440	COG1472	Belongs to the glycosyl hydrolase 3 family
NI17_006500	COG1518	maintenance of DNA repeat elements
NI17_006505	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NI17_006545	COG0110	maltose O-acetyltransferase activity
NI17_006585	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NI17_006615	COG2084	Dehydrogenase
NI17_006655	COG2207	Transcriptional regulator
NI17_006655	COG3708	Transcriptional regulator
NI17_006660	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NI17_006665	COG4335	DNA alkylation repair
NI17_006680	COG1028	Short-chain dehydrogenase reductase Sdr
NI17_006745	COG2124	cytochrome p450
NI17_006755	COG0604	alcohol dehydrogenase
NI17_006765	COG0183	Belongs to the thiolase family
NI17_006775	COG1024	Enoyl-CoA hydratase
NI17_006780	COG1960	acyl-CoA dehydrogenase activity
NI17_006785	COG1960	acyl-CoA dehydrogenase activity
NI17_006805	COG2030	dehydratase
NI17_006810	COG1012	belongs to the aldehyde dehydrogenase family
NI17_006815	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NI17_006850	COG0477	Major facilitator Superfamily
NI17_006865	COG1028	Short-chain dehydrogenase reductase Sdr
NI17_006880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NI17_006895	COG4106	trans-aconitate 2-methyltransferase activity
NI17_006905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NI17_006930	COG1595	DNA-templated transcription, initiation
NI17_006935	COG1252	NADH dehydrogenase
NI17_006940	COG0477	Major facilitator Superfamily
NI17_006945	COG0659	secondary active sulfate transmembrane transporter activity
NI17_006960	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
NI17_006965	COG0789	Transcriptional regulator
NI17_006975	COG3973	AAA domain
NI17_006980	COG1007	ATP synthesis coupled electron transport
NI17_006985	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NI17_006990	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NI17_006995	COG0713	ATP synthesis coupled electron transport
NI17_007005	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NI17_007015	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NI17_007025	COG0512	Glutamine amidotransferase of anthranilate synthase
NI17_007025	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NI17_007045	COG1121	(ABC) transporter
NI17_007050	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NI17_007060	COG1280	lysine exporter protein (LysE YggA)
NI17_007075	COG0583	DNA-binding transcription factor activity
NI17_007090	COG0179	Fumarylacetoacetate (FAA) hydrolase
NI17_007100	COG2267	carboxylic ester hydrolase activity
NI17_007120	COG4608	Belongs to the ABC transporter superfamily
NI17_007140	COG0747	negative chemotaxis
NI17_007150	COG1012	belongs to the aldehyde dehydrogenase family
NI17_007155	COG0579	oxidoreductase
NI17_007165	COG0028	Belongs to the TPP enzyme family
NI17_007190	COG1028	Short-chain dehydrogenase reductase Sdr
NI17_007215	COG0243	molybdopterin cofactor binding
NI17_007220	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NI17_007225	COG2890	protein-(glutamine-N5) methyltransferase activity
NI17_007235	COG2815	serine threonine protein kinase
NI17_007235	COG0515	serine threonine protein kinase
NI17_007240	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NI17_007240	COG3321	synthase
NI17_007265	COG2267	carboxylic ester hydrolase activity
NI17_007280	COG1309	transcriptional regulator
NI17_007285	COG1132	(ABC) transporter
NI17_007330	COG2267	carboxylic ester hydrolase activity
NI17_007335	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NI17_007350	COG0673	inositol 2-dehydrogenase activity
NI17_007360	COG1505	serine-type exopeptidase activity
NI17_007370	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NI17_007370	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NI17_007375	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NI17_007390	COG2146	nitrite reductase [NAD(P)H] activity
NI17_007390	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NI17_007395	COG2146	nitrite reductase [NAD(P)H] activity
NI17_007395	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NI17_007410	COG4585	Histidine kinase
NI17_007415	COG2197	response regulator
NI17_007430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NI17_007450	COG1234	tRNA 3'-trailer cleavage
NI17_007455	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NI17_007485	COG0439	Biotin carboxylase
NI17_007555	COG2226	methyltransferase
NI17_007560	COG3321	synthase
NI17_007560	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NI17_007565	COG1309	transcriptional regulator
NI17_007585	COG4974	Belongs to the 'phage' integrase family
NI17_007655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NI17_007660	COG2154	pterin-4-alpha-carbinolamine dehydratase
NI17_007750	COG3189	MarR family transcriptional regulator
NI17_007800	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
NI17_007800	COG2885	chlorophyll binding
NI17_007810	COG2072	flavoprotein involved in K transport
NI17_007825	COG3973	AAA domain
NI17_007840	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NI17_007895	COG1070	Carbohydrate kinase
NI17_007900	COG3347	Dehydrogenase
NI17_007900	COG1028	Short-chain dehydrogenase reductase Sdr
NI17_007905	COG4952	isomerase
NI17_007915	COG1879	ABC-type sugar transport system periplasmic component
NI17_007920	COG1172	Belongs to the binding-protein-dependent transport system permease family
NI17_007930	COG1129	ABC transporter
NI17_007935	COG1609	Transcriptional regulator
NI17_007945	COG1070	Carbohydrate kinase
NI17_007985	COG0640	Transcriptional regulator
NI17_007990	COG2217	Heavy metal translocating P-type atpase
NI17_008000	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NI17_008005	COG0514	ATP-dependent DNA helicase (RecQ)
NI17_008060	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NI17_008065	COG0602	queuosine metabolic process
NI17_008070	COG0720	synthase
NI17_008080	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NI17_008100	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NI17_008125	COG0583	DNA-binding transcription factor activity
NI17_008140	COG0254	rRNA binding
NI17_008160	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NI17_008185	COG0596	Alpha beta hydrolase
NI17_008215	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NI17_008230	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NI17_008235	COG3251	PFAM MbtH domain protein
NI17_008255	COG0134	indole-3-glycerol-phosphate synthase activity
NI17_008275	COG0159	tryptophan synthase activity
NI17_008280	COG0134	indole-3-glycerol-phosphate synthase activity
NI17_008310	COG3795	YCII-related domain
NI17_008315	COG4941	Belongs to the sigma-70 factor family
NI17_008320	COG0477	Major facilitator Superfamily
NI17_008365	COG4977	sequence-specific DNA binding
NI17_008365	COG1917	Cupin 2, conserved barrel domain protein
NI17_008375	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NI17_008420	COG2124	cytochrome p450
NI17_008450	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NI17_008470	COG1063	alcohol dehydrogenase
NI17_008480	COG1902	pentaerythritol trinitrate reductase activity
NI17_008495	COG3250	beta-galactosidase activity
NI17_008500	COG1175	transmembrane transport
NI17_008530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NI17_008565	COG2249	NAD(P)H dehydrogenase (quinone) activity
NI17_008575	COG1278	Cold shock
NI17_008585	COG2323	membrane
NI17_008595	COG2124	cytochrome p450
NI17_008600	COG4221	oxidoreductase activity
NI17_008625	COG2192	nodulation
NI17_008630	COG2226	methyltransferase
NI17_008665	COG0679	Auxin Efflux Carrier
NI17_008675	COG0179	Fumarylacetoacetate (FAA) hydrolase
NI17_008685	COG0667	Aldo Keto reductase
NI17_008700	COG0477	Major facilitator Superfamily
NI17_008705	COG0583	DNA-binding transcription factor activity
NI17_008735	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NI17_008760	COG1024	Enoyl-CoA hydratase
NI17_008765	COG0183	Belongs to the thiolase family
NI17_008800	COG1024	Enoyl-CoA hydratase
NI17_008805	COG0318	PFAM AMP-dependent synthetase and ligase
NI17_008815	COG1960	acyl-CoA dehydrogenase activity
NI17_008835	COG3311	Transcriptional regulator
NI17_008840	COG1028	Short-chain dehydrogenase reductase Sdr
NI17_008850	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NI17_008850	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NI17_008855	COG1703	isobutyryl-CoA mutase activity
NI17_008860	COG1024	Enoyl-CoA hydratase
NI17_008865	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NI17_008875	COG1028	Short-chain dehydrogenase reductase Sdr
NI17_008885	COG1250	3-hydroxyacyl-CoA dehydrogenase
NI17_008890	COG1024	Enoyl-CoA hydratase
NI17_008940	COG1053	succinate dehydrogenase
NI17_008955	COG1053	succinate dehydrogenase
NI17_008960	COG1902	pentaerythritol trinitrate reductase activity
NI17_008960	COG0446	pyridine nucleotide-disulphide oxidoreductase
NI17_008970	COG2030	dehydratase
NI17_008975	COG0789	Transcriptional regulator
NI17_008985	COG0789	Transcriptional regulator
NI17_009000	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NI17_009010	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NI17_009015	COG0655	NAD(P)H dehydrogenase (quinone) activity
NI17_009020	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NI17_009060	COG1960	acyl-CoA dehydrogenase activity
NI17_009065	COG0300	oxidoreductase activity
NI17_009080	COG0346	lactoylglutathione lyase activity
NI17_009090	COG0583	DNA-binding transcription factor activity
NI17_009125	COG1028	Short-chain dehydrogenase reductase Sdr
NI17_009130	COG0583	DNA-binding transcription factor activity
NI17_009135	COG3795	YCII-related domain
NI17_009140	COG4941	Belongs to the sigma-70 factor family
NI17_009165	COG0535	radical SAM domain protein
NI17_009185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NI17_009200	COG0252	asparaginase activity
NI17_009240	COG1309	transcriptional regulator
NI17_009305	COG1132	(ABC) transporter
NI17_009310	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NI17_009455	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NI17_009500	COG0124	histidyl-tRNA synthetase
NI17_009510	COG1131	(ABC) transporter
NI17_009530	COG0019	diaminopimelate decarboxylase activity
NI17_009575	COG2801	Transposase and inactivated derivatives
NI17_009585	COG2963	transposase activity
NI17_009800	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NI17_009805	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NI17_009825	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NI17_009870	COG0494	nUDIX hydrolase
NI17_009875	COG1388	LysM domain
NI17_009875	COG0791	NLP P60 protein
NI17_009875	COG3103	Sh3 type 3 domain protein
NI17_009910	COG3321	synthase
NI17_009910	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NI17_010020	COG1028	Short-chain dehydrogenase reductase Sdr
NI17_010025	COG0640	Transcriptional regulator
NI17_010100	COG1388	LysM domain
NI17_010100	COG3103	Sh3 type 3 domain protein
NI17_010100	COG0791	NLP P60 protein
NI17_010210	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
NI17_010215	COG1518	maintenance of DNA repeat elements
NI17_010225	COG1203	CRISPR-associated helicase, Cas3
NI17_010255	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
NI17_010265	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
NI17_010320	COG0667	Aldo Keto reductase
NI17_010340	COG0791	NLP P60 protein
NI17_010340	COG1388	LysM domain
NI17_010340	COG3103	Sh3 type 3 domain protein
NI17_010350	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NI17_010510	COG1203	CRISPR-associated helicase, Cas3
NI17_010525	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
NI17_010535	COG4974	Belongs to the 'phage' integrase family
NI17_010570	COG0791	NLP P60 protein
NI17_010570	COG1388	LysM domain
NI17_010570	COG3103	Sh3 type 3 domain protein
NI17_010645	COG1510	regulation of RNA biosynthetic process
NI17_010650	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
NI17_010655	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NI17_010670	COG1278	Cold shock
NI17_010690	COG0583	DNA-binding transcription factor activity
NI17_010695	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NI17_010700	COG1216	Glycosyl transferase, family 2
NI17_010710	COG0006	proline dipeptidase activity
NI17_010770	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NI17_010780	COG1120	ATPase activity
NI17_010785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NI17_010795	COG1742	UPF0060 membrane protein
NI17_010800	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
NI17_010805	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NI17_010815	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NI17_010835	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NI17_010840	COG2378	regulation of single-species biofilm formation
NI17_010845	COG3739	integral membrane protein
NI17_010895	COG3842	ATPase activity
NI17_010900	COG0438	transferase activity, transferring glycosyl groups
NI17_010905	COG0366	Alpha amylase catalytic
NI17_010910	COG4581	dead DEAH box helicase
NI17_010925	COG0805	protein transport
NI17_010970	COG1960	acyl-CoA dehydrogenase activity
NI17_011005	COG1028	Short-chain dehydrogenase reductase Sdr
NI17_011010	COG2186	Transcriptional regulator
NI17_011015	COG4948	Mandelate Racemase Muconate Lactonizing
NI17_011025	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NI17_011030	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NI17_011035	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NI17_011050	COG4122	O-methyltransferase activity
NI17_011060	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NI17_011070	COG1222	aaa ATPase
NI17_011105	COG1994	Peptidase M50
NI17_011105	COG0517	IMP dehydrogenase activity
NI17_011115	COG2197	response regulator
NI17_011155	COG0646	methionine synthase
NI17_011155	COG1410	methionine synthase
NI17_011180	COG0215	cysteine-tRNA ligase activity
NI17_011210	COG1968	undecaprenyl-diphosphatase activity
NI17_011215	COG0667	Aldo Keto reductase
NI17_011225	COG1028	Short-chain dehydrogenase reductase Sdr
NI17_011235	COG1028	Short-chain dehydrogenase reductase Sdr
NI17_011250	COG2197	response regulator
NI17_011255	COG4585	Histidine kinase
NI17_011260	COG0577	efflux transmembrane transporter activity
NI17_011260	COG1136	(ABC) transporter
NI17_011265	COG0577	efflux transmembrane transporter activity
NI17_011265	COG1136	(ABC) transporter
NI17_011310	COG2091	lysine biosynthetic process via aminoadipic acid
NI17_011315	COG1505	serine-type exopeptidase activity
NI17_011405	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
NI17_011415	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NI17_011420	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NI17_011445	COG1021	2,3-dihydroxybenzoate-AMP ligase
NI17_011450	COG1169	isochorismate synthase
NI17_011455	COG1028	Short-chain dehydrogenase reductase Sdr
NI17_011465	COG0701	Predicted permease
NI17_011470	COG2130	NADP-dependent
NI17_011480	COG0513	Belongs to the DEAD box helicase family
NI17_011495	COG0488	(ABC) transporter
NI17_011550	COG0175	sulfate reduction
NI17_011560	COG1960	acyl-CoA dehydrogenase activity
NI17_011575	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NI17_011580	COG0688	phosphatidylethanolamine metabolic process
NI17_011615	COG3253	May function as heme-dependent peroxidase
NI17_011620	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
NI17_011630	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NI17_011650	COG0183	Belongs to the thiolase family
NI17_011685	COG4941	Belongs to the sigma-70 factor family
NI17_011690	COG3795	YCII-related domain
NI17_011695	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NI17_011700	COG2409	Drug exporters of the RND superfamily
NI17_011720	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
NI17_011725	COG0493	'glutamate synthase
NI17_011735	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NI17_011740	COG3663	DNA glycosylase
NI17_011750	COG4214	carbohydrate transport
NI17_011760	COG4213	ABC transporter substrate-binding protein
NI17_011765	COG1940	carbohydrate kinase activity
NI17_011775	COG1595	DNA-templated transcription, initiation
NI17_011790	COG4607	ABC-type enterochelin transport system periplasmic component
NI17_011795	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NI17_011800	COG4605	iron ion homeostasis
NI17_011805	COG4604	ABC transporter, ATP-binding protein
NI17_011820	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NI17_011830	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NI17_011835	COG0569	domain protein
NI17_011845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NI17_011870	COG0756	dUTP diphosphatase activity
NI17_011875	COG0525	valine-tRNA ligase activity
NI17_011895	COG2205	protein histidine kinase activity
NI17_011900	COG0745	RESPONSE REGULATOR receiver
NI17_011920	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NI17_011955	COG0288	reversible hydration of carbon dioxide
NI17_011980	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NI17_011995	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
NI17_012005	COG5297	Belongs to the glycosyl hydrolase family 6
NI17_012005	COG4733	cellulase activity
NI17_012015	COG0009	L-threonylcarbamoyladenylate synthase
NI17_012025	COG2318	DinB family
NI17_012030	COG2813	Specifically methylates the guanine in position
NI17_012035	COG1396	sequence-specific DNA binding
NI17_012085	COG0432	Pfam Uncharacterised protein family UPF0047
NI17_012095	COG1984	allophanate hydrolase subunit 2
NI17_012100	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
NI17_012105	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NI17_012125	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NI17_012130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NI17_012135	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NI17_012165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NI17_012175	COG2151	metal-sulfur cluster biosynthetic enzyme
NI17_012180	COG0822	iron-sulfur transferase activity
NI17_012190	COG0396	ATPase activity
NI17_012215	COG1131	(ABC) transporter
NI17_012230	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NI17_012235	COG2235	arginine
NI17_012240	COG5006	permease, DMT superfamily
NI17_012270	COG0318	PFAM AMP-dependent synthetase and ligase
NI17_012275	COG1960	acyl-CoA dehydrogenase activity
NI17_012285	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NI17_012295	COG0109	protoheme IX farnesyltransferase activity
NI17_012305	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NI17_012325	COG0363	glucosamine-6-phosphate deaminase activity
NI17_012360	COG3401	FG-GAP repeat protein
NI17_012375	COG0531	amino acid
NI17_012390	COG0400	carboxylic ester hydrolase activity
NI17_012395	COG0346	lactoylglutathione lyase activity
NI17_012405	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NI17_012410	COG0149	triose-phosphate isomerase activity
NI17_012415	COG0126	phosphoglycerate kinase activity
NI17_012420	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NI17_012425	COG1481	regulation of sporulation
NI17_012435	COG1660	Displays ATPase and GTPase activities
NI17_012440	COG0322	excinuclease ABC activity
NI17_012460	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NI17_012495	COG0497	DNA recombination
NI17_012500	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NI17_012530	COG0647	UMP catabolic process
NI17_012545	COG0456	acetyltransferase
NI17_012575	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NI17_012600	COG5002	protein histidine kinase activity
NI17_012620	COG2018	Roadblock/LC7 domain
NI17_012630	COG0165	Argininosuccinate lyase
NI17_012635	COG0137	argininosuccinate synthase activity
NI17_012640	COG1438	arginine binding
NI17_012645	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NI17_012650	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NI17_012655	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NI17_012660	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NI17_012665	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
NI17_012670	COG1846	Transcriptional regulator
NI17_012680	COG0745	RESPONSE REGULATOR receiver
NI17_012685	COG2205	protein histidine kinase activity
NI17_012695	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NI17_012695	COG0072	phenylalanine-tRNA ligase activity
NI17_012700	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NI17_012705	COG5002	protein histidine kinase activity
NI17_012710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NI17_012715	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NI17_012720	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NI17_012725	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NI17_012730	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NI17_012740	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NI17_012745	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NI17_012750	COG1434	Gram-negative-bacterium-type cell wall biogenesis
NI17_012760	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NI17_012835	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NI17_012845	COG1196	nuclear chromosome segregation
NI17_012855	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NI17_012860	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NI17_012865	COG1862	Preprotein translocase
NI17_012870	COG2255	four-way junction helicase activity
NI17_012875	COG0632	four-way junction helicase activity
NI17_012880	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NI17_012885	COG0217	transcriptional regulatory protein
NI17_012890	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
NI17_012895	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
NI17_012905	COG0438	transferase activity, transferring glycosyl groups
NI17_012910	COG1560	Kdo2-lipid A biosynthetic process
NI17_012915	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NI17_012930	COG1253	flavin adenine dinucleotide binding
NI17_012945	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NI17_013005	COG3265	gluconokinase activity
NI17_013055	COG1733	regulation of RNA biosynthetic process
NI17_013065	COG1011	Hydrolase
NI17_013120	COG0045	succinate-CoA ligase (ADP-forming) activity
NI17_013130	COG0514	ATP-dependent DNA helicase (RecQ)
NI17_013130	COG0514	ATP-dependent DNA helicase (RecQ)
NI17_013140	COG1320	monovalent cation:proton antiporter activity
NI17_013145	COG2212	antiporter activity
NI17_013150	COG1863	multisubunit Na H antiporter MnhE subunit
NI17_013155	COG0651	ATP synthesis coupled electron transport
NI17_013160	COG1006	Multisubunit Na H antiporter MnhC subunit
NI17_013165	COG2111	Na H antiporter
NI17_013170	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NI17_013170	COG2111	Na H antiporter
NI17_013175	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NI17_013195	COG0187	DNA topoisomerase II activity
NI17_013210	COG3022	response to hydroperoxide
NI17_013225	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NI17_013245	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NI17_013255	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NI17_013280	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NI17_013285	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NI17_013290	COG1388	LysM domain
NI17_013295	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NI17_013315	COG0495	leucyl-tRNA aminoacylation
NI17_013325	COG0318	PFAM AMP-dependent synthetase and ligase
NI17_013330	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
NI17_013345	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NI17_013355	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NI17_013395	COG0395	ABC-type sugar transport system, permease component
NI17_013400	COG1175	transmembrane transport
NI17_013410	COG1609	Transcriptional regulator
NI17_013475	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NI17_013480	COG0501	Belongs to the peptidase M48B family
NI17_013500	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NI17_013515	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NI17_013520	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NI17_013525	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NI17_013530	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NI17_013535	COG1530	ribonuclease E activity
NI17_013560	COG0772	Belongs to the SEDS family
NI17_013575	COG0105	UTP biosynthetic process
NI17_013585	COG0285	dihydrofolate synthase activity
NI17_013610	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NI17_013615	COG0740	serine-type endopeptidase activity
NI17_013620	COG0740	serine-type endopeptidase activity
NI17_013625	COG0544	peptidyl-prolyl cis-trans isomerase activity
NI17_013640	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
NI17_013640	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NI17_013645	COG1132	(ABC) transporter
NI17_013660	COG2239	Acts as a magnesium transporter
NI17_013670	COG4552	Acetyltransferase involved in intracellular survival and related
NI17_013690	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NI17_013720	COG0129	dihydroxy-acid dehydratase activity
NI17_013735	COG1505	serine-type exopeptidase activity
NI17_013745	COG2271	Major facilitator Superfamily
NI17_013780	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NI17_013780	COG1648	precorrin-2 dehydrogenase activity
NI17_013785	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
NI17_013830	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
NI17_013845	COG0431	NADPH-dependent FMN reductase
NI17_013865	COG1176	ABC-type spermidine putrescine transport system, permease component I
NI17_013875	COG3842	ATPase activity
NI17_013895	COG0235	Class ii aldolase
NI17_013905	COG4585	Histidine kinase
NI17_013910	COG2197	response regulator
NI17_013915	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
NI17_013920	COG3766	membrane
NI17_013945	COG1522	sequence-specific DNA binding
NI17_013970	COG0477	Major facilitator Superfamily
NI17_013980	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NI17_013985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NI17_014000	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NI17_014025	COG1115	amino acid carrier protein
NI17_014045	COG0583	DNA-binding transcription factor activity
NI17_014060	COG0438	transferase activity, transferring glycosyl groups
NI17_014095	COG1597	lipid kinase activity
NI17_014125	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
NI17_014145	COG2894	cell division
NI17_014170	COG4585	Histidine kinase
NI17_014230	COG0667	Aldo Keto reductase
NI17_014250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NI17_014270	COG1230	cation diffusion facilitator family transporter
NI17_014275	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NI17_014280	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NI17_014285	COG0569	domain protein
NI17_014315	COG1960	acyl-CoA dehydrogenase activity
NI17_014320	COG1960	acyl-CoA dehydrogenase activity
NI17_014330	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NI17_014335	COG1122	ATPase activity
NI17_014340	COG1268	BioY protein
NI17_014345	COG2706	6-phosphogluconolactonase activity
NI17_014365	COG2018	Roadblock/LC7 domain
NI17_014375	COG1643	Atp-dependent helicase
NI17_014430	COG1737	Transcriptional regulator
NI17_014435	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NI17_014440	COG2949	membrane
NI17_014470	COG1595	DNA-templated transcription, initiation
NI17_014485	COG0753	catalase activity
NI17_014495	COG0210	DNA helicase
NI17_014540	COG3395	kinase activity
NI17_014545	COG0673	inositol 2-dehydrogenase activity
NI17_014550	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NI17_014555	COG1653	transport
NI17_014560	COG1175	transmembrane transport
NI17_014565	COG0395	ABC-type sugar transport system, permease component
NI17_014575	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NI17_014580	COG0784	Response regulator, receiver
NI17_014585	COG4251	negative regulation of phosphorylation
NI17_014595	COG5398	heme oxygenase
NI17_014625	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NI17_014630	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NI17_014635	COG0509	glycine decarboxylation via glycine cleavage system
NI17_014640	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NI17_014690	COG2815	serine threonine protein kinase
NI17_014690	COG0515	serine threonine protein kinase
NI17_014700	COG1025	Belongs to the peptidase M16 family
NI17_014720	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NI17_014725	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NI17_014730	COG1234	tRNA 3'-trailer cleavage
NI17_014760	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NI17_014770	COG1335	isochorismatase
NI17_014805	COG1678	Uncharacterized ACR, COG1678
NI17_014825	COG0183	Belongs to the thiolase family
NI17_014850	COG1250	3-hydroxyacyl-CoA dehydrogenase
NI17_014860	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
NI17_014900	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NI17_014905	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NI17_014910	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NI17_014915	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NI17_014920	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NI17_014925	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NI17_014930	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NI17_014950	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NI17_014960	COG2890	protein-(glutamine-N5) methyltransferase activity
NI17_014965	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NI17_014970	COG0254	rRNA binding
NI17_014980	COG0083	homoserine kinase activity
NI17_014985	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NI17_014990	COG0460	homoserine dehydrogenase
NI17_014995	COG0019	diaminopimelate decarboxylase activity
NI17_015005	COG0745	RESPONSE REGULATOR receiver
NI17_015015	COG2272	Belongs to the type-B carboxylesterase lipase family
NI17_015045	COG0242	peptide deformylase activity
NI17_015115	COG1061	Type III restriction enzyme res subunit
NI17_015120	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NI17_015125	COG1053	succinate dehydrogenase
NI17_015135	COG0583	DNA-binding transcription factor activity
NI17_015140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NI17_015145	COG1217	gtp-binding protein TYPA
NI17_015150	COG0494	nUDIX hydrolase
NI17_015190	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NI17_015195	COG2177	Part of the ABC transporter FtsEX involved in
NI17_015200	COG2884	Cell division ATP-binding protein ftsE
NI17_015205	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
NI17_015215	COG2902	Dehydrogenase
NI17_015230	COG1011	Hydrolase
NI17_015240	COG1472	Belongs to the glycosyl hydrolase 3 family
NI17_015265	COG0653	protein targeting
NI17_015275	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NI17_015285	COG5401	PFAM Sporulation and spore germination
NI17_015290	COG5002	protein histidine kinase activity
NI17_015290	COG5000	phosphorelay sensor kinase activity
NI17_015295	COG0745	RESPONSE REGULATOR receiver
NI17_015315	COG0714	Associated with various cellular activities
NI17_015335	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NI17_015355	COG2835	tetraacyldisaccharide 4'-kinase activity
NI17_015395	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NI17_015400	COG0778	Nitroreductase
NI17_015400	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
NI17_015405	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
NI17_015410	COG2226	methyltransferase
NI17_015420	COG2188	Transcriptional regulator
NI17_015495	COG1316	TRANSCRIPTIONal
NI17_015585	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NI17_015600	COG1316	TRANSCRIPTIONal
NI17_015610	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NI17_015615	COG1832	CoA-binding protein
NI17_015635	COG0745	RESPONSE REGULATOR receiver
NI17_015640	COG5002	protein histidine kinase activity
NI17_015650	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
NI17_015660	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NI17_015665	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NI17_015675	COG4770	biotin carboxylase activity
NI17_015735	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NI17_015740	COG1473	amidohydrolase
NI17_015740	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NI17_015745	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NI17_015750	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NI17_015755	COG1316	TRANSCRIPTIONal
NI17_015775	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NI17_015780	COG0138	bifunctional purine biosynthesis protein purh
NI17_015785	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NI17_015805	COG0045	succinate-CoA ligase (ADP-forming) activity
NI17_015840	COG1957	nucleoside hydrolase
NI17_015845	COG2197	response regulator
NI17_015850	COG4585	Histidine kinase
NI17_015865	COG2080	2 iron, 2 sulfur cluster binding
NI17_015885	COG0519	Catalyzes the synthesis of GMP from XMP
NI17_015885	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NI17_015900	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NI17_015910	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NI17_015915	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NI17_015925	COG0516	GMP reductase activity
NI17_015935	COG1595	DNA-templated transcription, initiation
NI17_015940	COG0459	protein refolding
NI17_015945	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NI17_015970	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NI17_015985	COG0802	atpase or kinase
NI17_015990	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NI17_016020	COG1072	(Pantothenic acid kinase))
NI17_016030	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NI17_016035	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NI17_016040	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NI17_016045	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NI17_016055	COG0101	tRNA pseudouridine synthase activity
NI17_016060	COG0203	ribosomal protein L17
NI17_016065	COG0202	RNA polymerase activity
NI17_016070	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NI17_016075	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NI17_016080	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NI17_016085	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NI17_016100	COG0563	adenylate kinase activity
NI17_016110	COG0200	Binds to the 23S rRNA
NI17_016115	COG1841	ribosomal large subunit assembly
NI17_016120	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NI17_016125	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NI17_016130	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NI17_016135	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NI17_016140	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NI17_016145	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NI17_016150	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NI17_016155	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NI17_016160	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NI17_016165	COG0255	Belongs to the universal ribosomal protein uL29 family
NI17_016170	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NI17_016175	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NI17_016180	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NI17_016185	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NI17_016190	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NI17_016195	COG0089	rRNA binding
NI17_016200	COG0088	Forms part of the polypeptide exit tunnel
NI17_016205	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NI17_016210	COG0051	transcription antitermination factor activity, RNA binding
NI17_016215	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NI17_016220	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NI17_016225	COG0049	tRNA binding
NI17_016230	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NI17_016240	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NI17_016245	COG0085	RNA polymerase activity
NI17_016255	COG0222	ribosome binding
NI17_016260	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NI17_016270	COG0081	regulation of translation
NI17_016275	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NI17_016285	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NI17_016295	COG0436	Aminotransferase
NI17_016300	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NI17_016305	COG2119	membrane
NI17_016310	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NI17_016320	COG2030	dehydratase
NI17_016325	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NI17_016340	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NI17_016365	COG1309	transcriptional regulator
NI17_016380	COG1666	GTP binding
NI17_016385	COG0501	Belongs to the peptidase M48B family
NI17_016390	COG0674	pyruvate-flavodoxin oxidoreductase activity
NI17_016390	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
NI17_016395	COG1013	pyruvate-flavodoxin oxidoreductase activity
NI17_016400	COG0671	phosphoesterase, PA-phosphatase related
NI17_016405	COG0702	epimerase
NI17_016425	COG1595	DNA-templated transcription, initiation
NI17_016435	COG2161	toxin-antitoxin pair type II binding
NI17_016445	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NI17_016460	COG0142	geranyltranstransferase activity
NI17_016465	COG1007	ATP synthesis coupled electron transport
NI17_016480	COG0713	ATP synthesis coupled electron transport
NI17_016490	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NI17_016495	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NI17_016500	COG1034	ATP synthesis coupled electron transport
NI17_016515	COG0649	NAD binding
NI17_016520	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NI17_016525	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NI17_016540	COG2226	methyltransferase
NI17_016560	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NI17_016570	COG0785	Cytochrome C biogenesis protein
NI17_016575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NI17_016590	COG0123	including yeast histone deacetylase and acetoin utilization protein
NI17_016595	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NI17_016605	COG1082	Xylose isomerase domain protein TIM barrel
NI17_016615	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
NI17_016655	COG2897	thiosulfate sulfurtransferase activity
NI17_016685	COG0406	alpha-ribazole phosphatase activity
NI17_016695	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NI17_016700	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NI17_016715	COG0113	porphobilinogen synthase activity
NI17_016725	COG0181	hydroxymethylbilane synthase activity
NI17_016730	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NI17_016735	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
NI17_016750	COG0745	RESPONSE REGULATOR receiver
NI17_016760	COG0456	acetyltransferase
NI17_016775	COG0581	inorganic phosphate transmembrane transporter activity
NI17_016780	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NI17_016785	COG0306	phosphate transporter
NI17_016805	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NI17_016850	COG1739	Uncharacterized protein family UPF0029
NI17_016860	COG0386	Belongs to the glutathione peroxidase family
NI17_016890	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NI17_016915	COG1486	melibiose metabolic process
NI17_016925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NI17_016975	COG2188	Transcriptional regulator
NI17_017005	COG0582	viral genome integration into host DNA
NI17_017025	COG1774	PSP1 C-terminal conserved region
NI17_017030	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NI17_017045	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NI17_017050	COG1754	DNA topoisomerase type I activity
NI17_017050	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NI17_017065	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NI17_017090	COG1609	Transcriptional regulator
NI17_017095	COG2382	esterase
NI17_017095	COG3507	Belongs to the glycosyl hydrolase 43 family
NI17_017095	COG3693	PFAM glycoside hydrolase, family 10
NI17_017115	COG0714	Associated with various cellular activities
NI17_017130	COG0438	transferase activity, transferring glycosyl groups
NI17_017245	COG1140	nitrate reductase beta subunit
NI17_017300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NI17_017330	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NI17_017365	COG1201	RNA secondary structure unwinding
NI17_017425	COG0789	Transcriptional regulator
NI17_017470	COG3903	Transcriptional regulator
NI17_017470	COG3629	intracellular signal transduction
NI17_017525	COG2813	Specifically methylates the guanine in position
NI17_017530	COG0515	serine threonine protein kinase
NI17_017530	COG2815	serine threonine protein kinase
NI17_017535	COG0210	DNA helicase
NI17_017555	COG2124	cytochrome p450
NI17_017580	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NI17_017585	COG2197	response regulator
NI17_017595	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NI17_017595	COG1703	isobutyryl-CoA mutase activity
NI17_017595	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NI17_017605	COG1063	alcohol dehydrogenase
NI17_017620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NI17_017635	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NI17_017640	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NI17_017650	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NI17_017670	COG0247	lactate metabolic process
NI17_017675	COG1139	Iron-sulfur cluster binding protein
NI17_017680	COG1556	Lactate utilization protein
NI17_017705	COG0277	FAD linked oxidase domain protein
NI17_017705	COG0247	lactate metabolic process
NI17_017710	COG0515	serine threonine protein kinase
NI17_017800	COG1115	amino acid carrier protein
NI17_017810	COG2186	Transcriptional regulator
NI17_017815	COG3629	intracellular signal transduction
NI17_017815	COG3903	Transcriptional regulator
NI17_017820	COG2814	Major facilitator Superfamily
NI17_017830	COG1028	Short-chain dehydrogenase reductase Sdr
NI17_017850	COG2814	Major facilitator Superfamily
NI17_017855	COG0604	alcohol dehydrogenase
NI17_017855	COG3321	synthase
NI17_017860	COG3629	intracellular signal transduction
NI17_017860	COG3903	Transcriptional regulator
NI17_017865	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NI17_017870	COG3275	phosphorelay sensor kinase activity
NI17_017875	COG3279	Response regulator of the LytR AlgR family
NI17_017885	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NI17_017895	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NI17_017900	COG0640	Transcriptional regulator
NI17_017905	COG0492	ferredoxin-NADP+ reductase activity
NI17_017925	COG0640	Transcriptional regulator
NI17_017930	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NI17_017935	COG0798	PFAM Bile acid sodium symporter
NI17_017940	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NI17_017950	COG2072	flavoprotein involved in K transport
NI17_018060	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NI17_018065	COG2144	transferase activity, transferring acyl groups
NI17_018110	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NI17_018185	COG3485	protocatechuate 3,4-dioxygenase
NI17_018230	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NI17_018240	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NI17_018250	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
NI17_018255	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NI17_018260	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NI17_018275	COG3655	Transcriptional regulator
NI17_018315	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NI17_018325	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NI17_018330	COG0302	gtp cyclohydrolase
NI17_018340	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
NI17_018345	COG0037	tRNA processing
NI17_018375	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NI17_018380	COG2027	D-alanyl-D-alanine carboxypeptidase
NI17_018390	COG2814	Major facilitator Superfamily
NI17_018395	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NI17_018400	COG1329	Transcriptional regulator
NI17_018410	COG5002	protein histidine kinase activity
NI17_018420	COG0588	phosphoglycerate mutase activity
NI17_018430	COG0438	transferase activity, transferring glycosyl groups
NI17_018455	COG0501	Belongs to the peptidase M48B family
NI17_018480	COG1490	D-aminoacyl-tRNA deacylase activity
NI17_018515	COG2113	Glycine betaine
NI17_018525	COG3448	diguanylate cyclase activity
NI17_018525	COG4175	Glycine betaine
NI17_018530	COG0705	Rhomboid family
NI17_018535	COG0717	Belongs to the dCTP deaminase family
NI17_018565	COG0596	Alpha beta hydrolase
NI17_018570	COG1316	TRANSCRIPTIONal
NI17_018575	COG1028	Short-chain dehydrogenase reductase Sdr
NI17_018595	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
NI17_018625	COG0435	Glutathione S-transferase
NI17_018635	COG0702	epimerase
NI17_018660	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NI17_018670	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NI17_018675	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NI17_018675	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NI17_018695	COG2311	Membrane
NI17_018720	COG1324	tolerance protein
NI17_018725	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NI17_018745	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NI17_018750	COG0151	Belongs to the GarS family
NI17_018765	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NI17_018770	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NI17_018775	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NI17_018785	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NI17_018805	COG1595	DNA-templated transcription, initiation
NI17_018845	COG0179	Fumarylacetoacetate (FAA) hydrolase
NI17_018860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NI17_018920	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NI17_018925	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
NI17_018930	COG1028	Short-chain dehydrogenase reductase Sdr
NI17_018990	COG2205	protein histidine kinase activity
NI17_018995	COG2197	response regulator
NI17_019015	COG1316	TRANSCRIPTIONal
NI17_019095	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NI17_019120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NI17_019140	COG4941	Belongs to the sigma-70 factor family
NI17_019160	COG1051	belongs to the nudix hydrolase family
NI17_019185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NI17_019200	COG0512	Glutamine amidotransferase of anthranilate synthase
NI17_019200	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NI17_019205	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
NI17_019220	COG0277	FAD linked oxidase domain protein
NI17_019225	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NI17_019230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NI17_019295	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NI17_019300	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NI17_019345	COG0589	response to stress
NI17_019350	COG0617	tRNA 3'-terminal CCA addition
NI17_019350	COG0517	IMP dehydrogenase activity
NI17_019350	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NI17_019355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NI17_019380	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NI17_019385	COG0443	Heat shock 70 kDa protein
NI17_019390	COG0484	heat shock protein binding
NI17_019405	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NI17_019410	COG0022	dehydrogenase e1 component
NI17_019410	COG0508	dehydrogenase complex catalyzes the overall conversion of
NI17_019415	COG0508	dehydrogenase complex catalyzes the overall conversion of
NI17_019430	COG0586	Pfam SNARE associated Golgi protein
NI17_019440	COG1215	transferase activity, transferring glycosyl groups
NI17_019445	COG1366	Belongs to the anti-sigma-factor antagonist family
NI17_019455	COG5002	protein histidine kinase activity
NI17_019460	COG0425	Belongs to the sulfur carrier protein TusA family
NI17_019460	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NI17_019480	COG1716	ATPase activity
NI17_019495	COG0768	penicillin binding
NI17_019500	COG0515	serine threonine protein kinase
NI17_019505	COG0515	serine threonine protein kinase
NI17_019515	COG0705	Rhomboid family
NI17_019570	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
NI17_019590	COG2837	iron assimilation
NI17_019630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NI17_019635	COG4977	sequence-specific DNA binding
NI17_019695	COG0359	binds to the 23S rRNA
NI17_019700	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NI17_019705	COG0629	single-stranded DNA binding
NI17_019710	COG0360	Binds together with S18 to 16S ribosomal RNA
NI17_019720	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
NI17_019775	COG2018	Roadblock/LC7 domain
NI17_019805	COG2815	serine threonine protein kinase
NI17_019805	COG0515	serine threonine protein kinase
NI17_019810	COG1595	DNA-templated transcription, initiation
NI17_019820	COG0492	ferredoxin-NADP+ reductase activity
NI17_019825	COG3118	belongs to the thioredoxin family
NI17_019835	COG1192	Involved in chromosome partitioning
NI17_019840	COG0357	Ribosomal RNA small subunit methyltransferase G
NI17_019850	COG0706	membrane insertase activity
NI17_019855	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NI17_019860	COG0594	ribonuclease P activity
NI17_019865	COG0230	Belongs to the bacterial ribosomal protein bL34 family
NI17_019870	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NI17_019875	COG0592	DNA-directed DNA polymerase activity
NI17_019880	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
NI17_019885	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NI17_019890	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
NI17_019895	COG0187	DNA topoisomerase II activity
NI17_019900	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NI17_019945	COG1518	maintenance of DNA repeat elements
NI17_019955	COG4974	Belongs to the 'phage' integrase family
NI17_019970	COG2208	phosphoserine phosphatase activity
NI17_019970	COG2770	Histidine kinase
NI17_020015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NI17_020055	COG2089	acid synthase
NI17_020060	COG1216	Glycosyl transferase, family 2
NI17_020070	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NI17_020070	COG2755	lipolytic protein G-D-S-L family
NI17_020090	COG1482	cell wall glycoprotein biosynthetic process
NI17_020130	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NI17_020155	COG2826	transposase and inactivated derivatives, IS30 family
NI17_020160	COG1674	ftsk spoiiie
NI17_020245	COG1366	Belongs to the anti-sigma-factor antagonist family
NI17_020250	COG1366	Belongs to the anti-sigma-factor antagonist family
NI17_020255	COG2172	sigma factor antagonist activity
NI17_020270	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NI17_020325	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NI17_020330	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NI17_020335	COG3387	PFAM Glycoside hydrolase 15-related
NI17_020340	COG0587	DNA-directed DNA polymerase activity
NI17_020565	COG1674	ftsk spoiiie
NI17_020605	COG2183	response to ionizing radiation
NI17_020635	COG0039	L-malate dehydrogenase activity
NI17_020655	COG0592	DNA-directed DNA polymerase activity
NI17_020680	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
NI17_020690	COG1028	Short-chain dehydrogenase reductase Sdr
NI17_020745	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NI17_020765	COG1960	acyl-CoA dehydrogenase activity
NI17_020780	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NI17_020790	COG0745	RESPONSE REGULATOR receiver
NI17_020810	COG2315	Protein conserved in bacteria
NI17_020850	COG2208	phosphoserine phosphatase activity
NI17_020855	COG2208	phosphoserine phosphatase activity
NI17_020860	COG2208	phosphoserine phosphatase activity
NI17_020865	COG1408	metallophosphoesterase
NI17_020875	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NI17_020910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NI17_020940	COG1366	Belongs to the anti-sigma-factor antagonist family
NI17_020945	COG1111	helicase
NI17_020945	COG1205	dead DEAH box helicase
NI17_020995	COG0596	Alpha beta hydrolase
NI17_021005	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
NI17_021015	COG0560	Phosphoserine phosphatase
NI17_021015	COG3830	Belongs to the UPF0237 family
NI17_021035	COG1119	ATPase activity
NI17_021050	COG0446	pyridine nucleotide-disulphide oxidoreductase
NI17_021060	COG1309	transcriptional regulator
NI17_021065	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NI17_021070	COG2843	Capsule synthesis protein
NI17_021080	COG0753	catalase activity
NI17_021100	COG2226	methyltransferase
NI17_021115	COG3866	Pectate lyase
NI17_021125	COG0657	acetylesterase activity
NI17_021130	COG0047	phosphoribosylformylglycinamidine synthase activity
NI17_021140	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NI17_021160	COG1476	TRANSCRIPTIONal
NI17_021170	COG1131	(ABC) transporter
NI17_021180	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NI17_021215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NI17_021230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NI17_021240	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NI17_021245	COG0140	phosphoribosyl-ATP diphosphatase activity
NI17_021250	COG0300	oxidoreductase activity
NI17_021260	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NI17_021265	COG1595	DNA-templated transcription, initiation
NI17_021275	COG0022	dehydrogenase e1 component
NI17_021280	COG0508	dehydrogenase complex catalyzes the overall conversion of
NI17_021295	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NI17_021315	COG0706	membrane insertase activity
NI17_021325	COG0181	hydroxymethylbilane synthase activity
NI17_021335	COG0800	Aldolase
NI17_021390	COG2181	nitrate reductase activity
NI17_021390	COG0247	lactate metabolic process
NI17_021395	COG0443	Heat shock 70 kDa protein
NI17_021400	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NI17_021405	COG0484	heat shock protein binding
NI17_021410	COG0789	Transcriptional regulator
NI17_021415	COG0542	response to heat
NI17_021440	COG1960	acyl-CoA dehydrogenase activity
NI17_021450	COG0215	cysteine-tRNA ligase activity
NI17_021455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NI17_021475	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NI17_021510	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NI17_021515	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NI17_021520	COG0459	protein refolding
NI17_021560	COG1278	Cold shock
NI17_021595	COG2252	PERMEase
NI17_021605	COG2814	Major facilitator Superfamily
NI17_021610	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
NI17_021620	COG0584	glycerophosphoryl diester phosphodiesterase
NI17_021640	COG0259	pyridoxamine-phosphate oxidase activity
NI17_021650	COG1366	Belongs to the anti-sigma-factor antagonist family
NI17_021650	COG2172	sigma factor antagonist activity
NI17_021650	COG2208	phosphoserine phosphatase activity
NI17_021660	COG1295	ribonuclease BN
NI17_021670	COG0183	Belongs to the thiolase family
NI17_021685	COG2205	protein histidine kinase activity
NI17_021690	COG0745	RESPONSE REGULATOR receiver
NI17_021700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NI17_021715	COG0116	Belongs to the methyltransferase superfamily
NI17_021715	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NI17_021720	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
NI17_021815	COG0416	fatty acid biosynthetic process
NI17_021825	COG1940	carbohydrate kinase activity
NI17_021840	COG1024	Enoyl-CoA hydratase
NI17_021850	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NI17_021855	COG1012	belongs to the aldehyde dehydrogenase family
NI17_021860	COG3842	ATPase activity
NI17_021870	COG1176	ABC-type spermidine putrescine transport system, permease component I
NI17_021875	COG1177	transmembrane transport
NI17_021880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NI17_021890	COG4999	Histidine kinase
NI17_021890	COG3850	Histidine kinase
NI17_021890	COG3437	response regulator, receiver
NI17_021890	COG2205	protein histidine kinase activity
NI17_021905	COG2212	antiporter activity
NI17_021910	COG1863	multisubunit Na H antiporter MnhE subunit
NI17_021915	COG0651	ATP synthesis coupled electron transport
NI17_021920	COG1006	Multisubunit Na H antiporter MnhC subunit
NI17_021925	COG2111	Na H antiporter
NI17_021925	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NI17_021930	COG2197	response regulator
NI17_021935	COG4585	Histidine kinase
NI17_021970	COG0438	transferase activity, transferring glycosyl groups
NI17_021980	COG0631	protein serine/threonine phosphatase activity
NI17_021985	COG2372	response to copper ion
NI17_021985	COG1276	copper resistance
NI17_021995	COG0456	acetyltransferase
NI17_022005	COG1917	Cupin 2, conserved barrel domain protein
NI17_022010	COG5285	phytanoyl-CoA dioxygenase
NI17_022020	COG0765	amino acid transport
NI17_022025	COG0765	amino acid transport
NI17_022030	COG1126	abc transporter atp-binding protein
NI17_022035	COG1492	cobalamin metabolic process
NI17_022045	COG1797	cobyrinic acid a,c-diamide synthase activity
NI17_022130	COG0508	dehydrogenase complex catalyzes the overall conversion of
NI17_022130	COG0596	Alpha beta hydrolase
NI17_022155	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NI17_022160	COG0406	alpha-ribazole phosphatase activity
NI17_022160	COG0494	nUDIX hydrolase
NI17_022195	COG0725	ABC transporter, periplasmic molybdate-binding protein
NI17_022200	COG4585	Histidine kinase
NI17_022235	COG1120	ATPase activity
NI17_022240	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NI17_022245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NI17_022270	COG0745	RESPONSE REGULATOR receiver
NI17_022280	COG1320	monovalent cation:proton antiporter activity
NI17_022285	COG2212	antiporter activity
NI17_022295	COG0651	ATP synthesis coupled electron transport
NI17_022300	COG1006	Multisubunit Na H antiporter MnhC subunit
NI17_022305	COG2111	Na H antiporter
NI17_022305	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NI17_022310	COG1846	Transcriptional regulator
NI17_022320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NI17_022345	COG0589	response to stress
NI17_022350	COG3973	AAA domain
NI17_022355	COG3384	dioxygenase
NI17_022360	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
NI17_022405	COG1802	Transcriptional regulator
NI17_022485	COG1674	ftsk spoiiie
NI17_022490	COG1404	Belongs to the peptidase S8 family
NI17_022525	COG1876	peptidase activity
NI17_022530	COG1970	mechanosensitive ion channel activity
NI17_022555	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NI17_022565	COG0315	cyclic pyranopterin monophosphate synthase activity
NI17_022570	COG0521	Mo-molybdopterin cofactor biosynthetic process
NI17_022575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NI17_022600	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NI17_022630	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NI17_022640	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NI17_022665	COG0084	hydrolase, TatD family'
NI17_022670	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NI17_022705	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NI17_022715	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NI17_022720	COG0789	Transcriptional regulator
NI17_022725	COG0488	(ABC) transporter
NI17_022735	COG1846	Transcriptional regulator
NI17_022760	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NI17_022765	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NI17_022770	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NI17_022775	COG0193	aminoacyl-tRNA hydrolase activity
NI17_022780	COG1218	3'(2'),5'-bisphosphate nucleotidase
NI17_022795	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NI17_022800	COG1959	2 iron, 2 sulfur cluster binding
NI17_022820	COG0529	Catalyzes the synthesis of activated sulfate
NI17_022835	COG0730	response to heat
NI17_022840	COG0148	phosphopyruvate hydratase activity
NI17_022860	COG1252	NADH dehydrogenase
NI17_022870	COG1012	belongs to the aldehyde dehydrogenase family
NI17_022875	COG0506	proline dehydrogenase activity
NI17_022890	COG0183	Belongs to the thiolase family
NI17_022895	COG2755	lipolytic protein G-D-S-L family
NI17_022905	COG0110	maltose O-acetyltransferase activity
NI17_022935	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
NI17_022950	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NI17_022960	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NI17_022970	COG1331	Highly conserved protein containing a thioredoxin domain
NI17_022980	COG0515	serine threonine protein kinase
NI17_022980	COG2815	serine threonine protein kinase
NI17_022990	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NI17_022995	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NI17_023005	COG0114	fumarate hydratase activity
NI17_023020	COG0842	Transport permease protein
NI17_023050	COG1722	exodeoxyribonuclease VII activity
NI17_023055	COG1570	exodeoxyribonuclease VII activity
NI17_023070	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NI17_023080	COG1322	Protein conserved in bacteria
NI17_023085	COG0012	GTP binding
NI17_023165	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NI17_023175	COG1994	Peptidase M50
NI17_023205	COG2171	N-acyltransferase activity
NI17_023210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NI17_023215	COG1611	Belongs to the LOG family
NI17_023225	COG0519	Catalyzes the synthesis of GMP from XMP
NI17_023240	COG1024	Enoyl-CoA hydratase
NI17_023250	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NI17_023255	COG4122	O-methyltransferase activity
NI17_023260	COG1595	DNA-templated transcription, initiation
NI17_023275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NI17_023295	COG0613	PHP domain protein
NI17_023310	COG0513	Belongs to the DEAD box helicase family
NI17_023330	COG0668	transmembrane transport
NI17_023365	COG0210	DNA helicase
NI17_023400	COG1946	Acyl-CoA thioesterase
NI17_023420	COG0415	Belongs to the DNA photolyase family
NI17_023440	COG0314	molybdopterin synthase activity
NI17_023445	COG3480	Lon protease (S16) C-terminal proteolytic domain
NI17_023455	COG1615	UPF0182 protein
NI17_023490	COG1136	(ABC) transporter
NI17_023490	COG0577	efflux transmembrane transporter activity
NI17_023495	COG0483	inositol monophosphate 1-phosphatase activity
NI17_023500	COG1162	GTPase activity
NI17_023505	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NI17_023520	COG2135	peptidase activity
NI17_023530	COG1595	DNA-templated transcription, initiation
NI17_023535	COG5662	AntiSigma factor
NI17_023540	COG2199	diguanylate cyclase activity
NI17_023540	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
NI17_023550	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
NI17_023565	COG2188	Transcriptional regulator
NI17_023580	COG1597	lipid kinase activity
NI17_023595	COG2172	sigma factor antagonist activity
NI17_023605	COG1126	abc transporter atp-binding protein
NI17_023610	COG0765	amino acid transport
NI17_023615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NI17_023620	COG0281	malic enzyme
NI17_023645	COG0508	dehydrogenase complex catalyzes the overall conversion of
NI17_023645	COG0567	Dehydrogenase, E1 component
NI17_023650	COG1028	Short-chain dehydrogenase reductase Sdr
NI17_023670	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NI17_023685	COG0438	transferase activity, transferring glycosyl groups
NI17_023700	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NI17_023720	COG1174	glycine betaine transport
NI17_023725	COG1174	glycine betaine transport
NI17_023745	COG0616	signal peptide processing
NI17_023760	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NI17_023775	COG0366	Alpha amylase catalytic
NI17_023780	COG0058	SHG alpha-glucan phosphorylase activity
NI17_023790	COG1122	ATPase activity
NI17_023795	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NI17_023810	COG2815	serine threonine protein kinase
NI17_023810	COG0515	serine threonine protein kinase
NI17_023820	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NI17_023835	COG0482	sulfurtransferase activity
NI17_023850	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NI17_023860	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NI17_023865	COG0154	amidase activity
NI17_023880	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NI17_023885	COG3300	MHYT domain
NI17_023885	COG5001	Diguanylate cyclase
NI17_023900	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NI17_023905	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NI17_023910	COG0473	3-isopropylmalate dehydrogenase activity
NI17_023915	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NI17_023920	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NI17_024095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NI17_024105	COG0305	Participates in initiation and elongation during chromosome replication
NI17_024190	COG1388	LysM domain
NI17_024190	COG3103	Sh3 type 3 domain protein
NI17_024190	COG0791	NLP P60 protein