locus-tag	class	description
Tbis_0001	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
Tbis_0002	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
Tbis_0003	ENOG4108J5G	6-phosphogluconate dehydrogenase
Tbis_0004	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
Tbis_0005	ENOG4105K7N	UPF0232 protein
Tbis_0006	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
Tbis_0007	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
Tbis_0009	ENOG4105KK4	UPF0060 membrane protein
Tbis_0015	ENOG4107R3E	Citrate transporter
Tbis_0018	ENOG4108IPW	abc transporter atp-binding protein
Tbis_0019	ENOG4105CM4	permease protein
Tbis_0020	ENOG4105DHS	permease protein
Tbis_0040	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
Tbis_0042	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
Tbis_0046	ENOG4108KGH	TRANSCRIPTIONal
Tbis_0050	ENOG4105HZM	Fha domain containing protein
Tbis_0053	ENOG4105CJN	penicillin-binding protein
Tbis_0054	ENOG4107TPY	serine threonine protein kinase
Tbis_0057	ENOG4105ZJT	Cell division protein CrgA
Tbis_0064	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
Tbis_0068	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
Tbis_0069	ENOG4105XN3	extracellular solute-binding protein family 1
Tbis_0072	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
Tbis_0073	ENOG4105VEQ	Cold shock protein
Tbis_0074	ENOG410667J	hydrolase
Tbis_0076	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
Tbis_0091	ENOG41073TP	transcriptional regulator
Tbis_0095	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
Tbis_0097	ENOG4108UGD	Serine Threonine protein kinase
Tbis_0098	ENOG4105E8R	UPF0173 metal-dependent hydrolase
Tbis_0119	ENOG4105NAF	rna polymerase sigma factor
Tbis_0121	ENOG41090MY	MarR family Transcriptional regulator
Tbis_0128	ENOG4105F27	Major Facilitator
Tbis_0129	ENOG4108Z6Z	Transcriptional regulator
Tbis_0130	ENOG4105W1N	transcriptional regulator
Tbis_0134	ENOG4105BZG	amino acid carrier protein
Tbis_0137	ENOG41086D8	Transcriptional regulator
Tbis_0140	ENOG4107TVJ	,Oxidoreductase FAD NAD(P)-binding
Tbis_0141	ENOG4105EJ7	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity)
Tbis_0147	ENOG4108UYE	Lactoylglutathione lyase
Tbis_0149	ENOG4105E2R	ROK family
Tbis_0155	ENOG4105GWZ	Roadblock lc7 family protein
Tbis_0160	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
Tbis_0162	ENOG4107QQG	Dehydrogenase
Tbis_0166	ENOG4105CIH	Imidazole acetol-phosphate transaminase
Tbis_0168	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
Tbis_0169	ENOG4105C8V	SAICAR synthetase
Tbis_0170	ENOG4105C12	Phosphoribosylglycinamide synthetase
Tbis_0172	ENOG4108MHR	Repressor involved in choline regulation of the bet genes (By similarity)
Tbis_0175	ENOG4107VXM	glycerophosphoryl diester phosphodiesterase
Tbis_0176	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
Tbis_0181	ENOG41065E1	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
Tbis_0184	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
Tbis_0185	ENOG4105BZU	Histidine kinase
Tbis_0195	ENOG4105BZ4	penicillin-binding protein
Tbis_0203	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
Tbis_0205	ENOG4105CSM	endonuclease III
Tbis_0207	ENOG4105C0H	protease
Tbis_0209	ENOG4105D74	hydrolase
Tbis_0211	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
Tbis_0220	ENOG4108I5C	dEAD DEAH box helicase
Tbis_0221	ENOG4105WN5	stage II sporulation protein
Tbis_0223	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Tbis_0225	ENOG4105EAC	phosphoserine phosphatase
Tbis_0227	ENOG4105ENE	Histidine kinase
Tbis_0228	ENOG4105WH1	Two component transcriptional regulator luxr family
Tbis_0229	ENOG4105DKW	ABC transporter
Tbis_0239	ENOG4108SGK	Tetr family transcriptional regulator
Tbis_0243	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
Tbis_0244	ENOG4105KNI	merR family transcriptional Regulator
Tbis_0245	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
Tbis_0246	ENOG4108093	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Tbis_0247	ENOG4105CFG	Acts as a chaperone (By similarity)
Tbis_0249	ENOG4105II7	pyrroline-5-carboxylate reductase
Tbis_0250	ENOG4105DGU	Histone deacetylase
Tbis_0255	ENOG4108RXW	HAD-superfamily subfamily IB hydrolase
Tbis_0260	ENOG4105FF6	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
Tbis_0261	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
Tbis_0262	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
Tbis_0264	ENOG4105D52	delta-aminolevulinic acid dehydratase
Tbis_0266	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
Tbis_0267	ENOG4105JQN	Transcriptional regulator
Tbis_0268	ENOG4108RH7	phosphoglycerate mutase
Tbis_0269	ENOG4107QX9	Thiol disulfide interChange protein
Tbis_0270	ENOG4107QIV	Cytochrome c biogenesis protein
Tbis_0272	ENOG4105CRE	cytochrome C
Tbis_0278	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
Tbis_0282	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Tbis_0283	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Tbis_0284	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Tbis_0287	ENOG4108IEH	NADH dehydrogenase subunit g
Tbis_0288	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
Tbis_0289	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Tbis_0290	ENOG4105DF2	NADH dehydrogenase subunit j
Tbis_0291	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Tbis_0294	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Tbis_0305	ENOG4108RNG	Permease of the drug metabolite transporter
Tbis_0306	ENOG4105EFJ	Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity)
Tbis_0307	ENOG4105C3U	ABC transporter
Tbis_0308	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Tbis_0310	ENOG4106R87	Extracellular solute-binding protein, family 5
Tbis_0313	ENOG4105DQU	oxidoreductase, subunit beta
Tbis_0314	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
Tbis_0315	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Tbis_0316	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Tbis_0317	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Tbis_0318	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
Tbis_0320	ENOG4108M11	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Tbis_0322	ENOG41082X4	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Tbis_0324	ENOG4105C8S	subunit m
Tbis_0325	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Tbis_0326	ENOG4105D0M	Protease HtpX homolog
Tbis_0328	ENOG4105EAD	ABC transporter
Tbis_0329	ENOG4107R0W	ABC transporter
Tbis_0332	ENOG4108VPT	UPF0234 protein
Tbis_0341	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
Tbis_0343	ENOG4107UQD	Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity)
Tbis_0344	ENOG4108Z7F	N-acetyltransferase
Tbis_0345	ENOG41082BM	Transcriptional regulator, arsr family
Tbis_0352	ENOG4106R7G	Glycoside hydrolase family 5
Tbis_0353	ENOG4105WN5	stage II sporulation protein
Tbis_0356	ENOG4105WDJ	50S ribosomal protein L33
Tbis_0357	ENOG410900P	UPF0336 protein
Tbis_0359	ENOG4107R4N	Cell wall formation (By similarity)
Tbis_0361	ENOG4107SM8	Adenylate Guanylate cyclase
Tbis_0363	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
Tbis_0364	ENOG4105C26	Dehydrogenase
Tbis_0365	ENOG4105C26	Dehydrogenase
Tbis_0368	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
Tbis_0370	ENOG4107SIG	periplasmic solute binding protein
Tbis_0371	ENOG4105DIK	(ABC) transporter
Tbis_0372	ENOG4105CC5	ABC transporter
Tbis_0373	ENOG4105CC5	ABC transporter
Tbis_0380	ENOG4105YVS	arsR family transcriptional regulator
Tbis_0381	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
Tbis_0382	ENOG41079Y2	Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone
Tbis_0387	ENOG41081QJ	UBA THIF-type NAD FAD binding
Tbis_0388	ENOG4107S46	esterase, PHB depolymerase
Tbis_0389	ENOG4105M03	Domain of unknown function (DUF955)
Tbis_0394	ENOG4105CJW	magnesium transporter
Tbis_0395	ENOG41083TI	Protein CrcB homolog
Tbis_0396	ENOG4105KJJ	Uncharacterized ACR, COG1993
Tbis_0397	ENOG41083YR	Protein CrcB homolog
Tbis_0403	ENOG4108Q5F	Tetr family transcriptional regulator
Tbis_0404	ENOG4105CP9	extracellular ligand-binding receptor
Tbis_0405	ENOG4105C32	Amino acid ABC transporter (Permease)
Tbis_0406	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
Tbis_0407	ENOG4105C0Z	ABC transporter
Tbis_0408	ENOG4108IV0	ABC, transporter
Tbis_0409	ENOG4108N23	SpoOM-related protein
Tbis_0410	ENOG41080XQ	Signal transduction protein with cbs domains
Tbis_0412	ENOG4105PF9	Transcriptional regulator
Tbis_0415	ENOG4105CEY	Amp-dependent synthetase and ligase
Tbis_0418	ENOG4105C0Z	ABC transporter
Tbis_0419	ENOG4108IV0	ABC, transporter
Tbis_0420	ENOG4105C32	Amino acid ABC transporter (Permease)
Tbis_0433	ENOG4105CHU	acetyl-coa acetyltransferase
Tbis_0435	ENOG41082YX	Transcriptional regulator, arsr family
Tbis_0436	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
Tbis_0442	ENOG4105KPY	Small multidrug resistance protein
Tbis_0448	ENOG4105DHP	deoxycytidine triphosphate deaminase
Tbis_0451	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
Tbis_0452	ENOG4105CGH	5'-nucleotidase
Tbis_0453	ENOG4107NHD	transcriptional regulator
Tbis_0460	ENOG4105KHC	sulfurtransferase
Tbis_0461	ENOG4105PKJ	carbohydrate binding
Tbis_0468	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
Tbis_0469	ENOG4105F1K	Glutamine amidotransferase
Tbis_0471	ENOG4108X6U	May play a role in the intracellular transport of hydrophobic ligands
Tbis_0473	ENOG4107XWZ	ferric uptake regulator
Tbis_0474	ENOG4107MMM	Anti-sigma-factor antagonist
Tbis_0475	ENOG4105FUA	antagonist
Tbis_0476	ENOG4105QD0	anti-sigma regulatory factor serine threonine protein kinase
Tbis_0478	ENOG4105BZU	Histidine kinase
Tbis_0480	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
Tbis_0481	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
Tbis_0483	ENOG4105JQZ	Methyltransferase
Tbis_0485	ENOG4105D7N	magnesium and cobalt transport protein CorA
Tbis_0489	ENOG4105D0M	Protease HtpX homolog
Tbis_0494	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
Tbis_0496	ENOG4107RPC	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
Tbis_0498	ENOG4105BZU	Histidine kinase
Tbis_0501	ENOG4108VJ1	Transcriptional regulator (CarD family
Tbis_0502	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
Tbis_0506	ENOG4105C8N	cysteinyl-tRNA synthetase
Tbis_0510	ENOG4107YPT	transcriptional regulator
Tbis_0512	ENOG4105G01	cobalamin (vitamin B12) biosynthesis CbiM protein
Tbis_0515	ENOG4108JJB	ABC transporter
Tbis_0517	ENOG4106YT9	Enoyl-CoA hydratase
Tbis_0519	ENOG4107R8H	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
Tbis_0521	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
Tbis_0522	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
Tbis_0526	ENOG4105C1G	acyl-Coa dehydrogenase
Tbis_0531	ENOG4105CHU	acetyl-coa acetyltransferase
Tbis_0533	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
Tbis_0536	ENOG410683Z	Preprotein translocase SecE subunit
Tbis_0538	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
Tbis_0539	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
Tbis_0542	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
Tbis_0543	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Tbis_0544	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Tbis_0545	ENOG4105CSA	Coproporphyrinogen iii oxidase
Tbis_0546	ENOG4106A3M	Cytochrome p-450
Tbis_0547	ENOG4106A3M	Cytochrome p-450
Tbis_0556	ENOG4105CH2	amidohydrolase
Tbis_0557	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
Tbis_0558	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
Tbis_0559	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
Tbis_0561	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
Tbis_0562	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
Tbis_0563	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
Tbis_0564	ENOG4105KZR	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
Tbis_0565	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Tbis_0566	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
Tbis_0567	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
Tbis_0568	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
Tbis_0569	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
Tbis_0570	ENOG41082SA	50s ribosomal protein l29
Tbis_0571	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
Tbis_0572	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
Tbis_0573	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
Tbis_0574	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Tbis_0575	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
Tbis_0576	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
Tbis_0577	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
Tbis_0578	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
Tbis_0579	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
Tbis_0580	ENOG410849U	50S ribosomal protein L30
Tbis_0581	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
Tbis_0583	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
Tbis_0588	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
Tbis_0589	ENOG41067V7	50S ribosomal protein L36
Tbis_0590	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Tbis_0591	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
Tbis_0592	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
Tbis_0593	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Tbis_0594	ENOG4108ZT0	50S ribosomal protein l17
Tbis_0595	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
Tbis_0599	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
Tbis_0600	ENOG4108UJD	30S ribosomal protein S9
Tbis_0601	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
Tbis_0603	ENOG4105CJ1	ABC, transporter
Tbis_0606	ENOG4105CS9	pantothenic acid kinase
Tbis_0607	ENOG41082KK	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
Tbis_0609	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
Tbis_0611	ENOG4108097	ATP-binding protein
Tbis_0616	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
Tbis_0619	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
Tbis_0620	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
Tbis_0621	ENOG4108MMM	RNA Polymerase
Tbis_0624	ENOG4107QVP	Dehydrogenase
Tbis_0625	ENOG4105CE4	GlcNAc 6-P deacetylase
Tbis_0626	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
Tbis_0627	ENOG4105C26	Dehydrogenase
Tbis_0629	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
Tbis_0631	ENOG4108Z4X	TRANSCRIPTIONal
Tbis_0632	ENOG4107QVI	Methyltransferase, type 11
Tbis_0635	ENOG4105CKK	Glycosyl transferase, family 2
Tbis_0636	ENOG4105K64	Glycosyl transferase, family 2
Tbis_0637	ENOG4107SJB	teichoic acid biosynthesis
Tbis_0639	ENOG4105C39	capsular polysaccharide phosphotransferase
Tbis_0641	ENOG4107RDJ	Sulfotransferase
Tbis_0646	ENOG4105CZ6	Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity)
Tbis_0649	ENOG4105WH1	Two component transcriptional regulator luxr family
Tbis_0651	ENOG4108KZ5	Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity)
Tbis_0654	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
Tbis_0660	ENOG4105DC1	bifunctional purine biosynthesis protein purh
Tbis_0661	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
Tbis_0663	ENOG4105BZN	citrate synthase
Tbis_0670	ENOG4105C31	Tryptophanyl-tRNA synthetase
Tbis_0674	ENOG4106KXD	ATP-dependent carboxylate-amine ligase (By similarity)
Tbis_0675	ENOG4107RM1	amidohydrolase
Tbis_0676	ENOG4105DIH	basic membrane
Tbis_0677	ENOG4108JQ9	ABC transporter
Tbis_0678	ENOG4105UIB	(ABC) transporter
Tbis_0684	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
Tbis_0686	ENOG4107QSU	Phosphoglucomutase phosphomannomutase alpha beta alpha domain
Tbis_0691	ENOG4108JIK	carboxylase
Tbis_0693	ENOG4105EC2	ftsk spoIIIe
Tbis_0696	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
Tbis_0700	ENOG4105D8K	carboxyl transferase
Tbis_0701	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
Tbis_0704	ENOG4108QER	Adenylate cyclase
Tbis_0706	ENOG4108UQY	Iron-storage protein
Tbis_0707	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
Tbis_0708	ENOG4105ES5	Histidine kinase
Tbis_0713	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
Tbis_0716	ENOG4105KT7	mgtC SapB transporter
Tbis_0717	ENOG4108KGH	TRANSCRIPTIONal
Tbis_0719	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
Tbis_0723	ENOG4108MDK	Dehydrogenase
Tbis_0727	ENOG4108TGC	Acyltransferase
Tbis_0728	ENOG4107TB5	TRANSCRIPTIONal
Tbis_0731	ENOG4105CKK	Glycosyl transferase, family 2
Tbis_0732	ENOG4107Y2G	Glycosyl transferase (Group 1
Tbis_0736	ENOG4105C4M	(Ubiquinol oxidase) subunit I
Tbis_0737	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
Tbis_0738	ENOG4108JJ9	ABC, transporter
Tbis_0739	ENOG4108JJ8	(ABC) transporter
Tbis_0740	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
Tbis_0742	ENOG41089UC	methyltransferase, type 11
Tbis_0746	ENOG4105DKF	Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity)
Tbis_0748	ENOG41088YA	Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity)
Tbis_0749	ENOG4105EIH	LPPG Fo 2-phospho-L-lactate transferase
Tbis_0751	ENOG4105K51	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity)
Tbis_0752	ENOG4107RGC	Glycosyl transferase, family 2
Tbis_0757	ENOG4105W49	UPF0434 protein
Tbis_0762	ENOG4108Z6Z	Transcriptional regulator
Tbis_0763	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
Tbis_0764	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
Tbis_0770	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
Tbis_0771	ENOG4105BZU	Histidine kinase
Tbis_0772	ENOG4105G3P	Lipoprotein lpqB
Tbis_0774	ENOG4108S7Q	sigma 54 modulation protein ribosomal protein S30ea
Tbis_0775	ENOG4105WH1	Two component transcriptional regulator luxr family
Tbis_0777	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
Tbis_0780	ENOG4107S46	esterase, PHB depolymerase
Tbis_0781	ENOG4105FDP	GntR family transcriptional regulator
Tbis_0782	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
Tbis_0783	ENOG4105D17	glycoside hydrolase, family 3 domain protein
Tbis_0784	ENOG4107S75	HAD-superfamily hydrolase subfamily IA variant 3
Tbis_0787	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
Tbis_0788	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
Tbis_0789	ENOG4105C7I	Dehydrogenase
Tbis_0791	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
Tbis_0793	ENOG4105CAK	Cell division ATP-binding protein ftsE
Tbis_0794	ENOG4107RYD	Part of the ABC transporter FtsEX involved in cellular division (By similarity)
Tbis_0795	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
Tbis_0798	ENOG4105C0H	protease
Tbis_0801	ENOG4105D2B	acyl-CoA dehydrogenase
Tbis_0805	ENOG41073B4	coagulation factor 5 8 type domain-containing protein
Tbis_0807	ENOG4108M6P	methyltransferase
Tbis_0812	ENOG4105IQ5	FAD linked oxidase domain protein
Tbis_0813	ENOG4108RG3	short-chain dehydrogenase reductase
Tbis_0814	ENOG4106T9R	serine protease
Tbis_0815	ENOG4108KSA	LysR family transcriptional regulator
Tbis_0820	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
Tbis_0821	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
Tbis_0822	ENOG4105DCF	alanine dehydrogenase
Tbis_0824	ENOG4107SWG	transcriptional regulator MERR family
Tbis_0825	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
Tbis_0826	ENOG4107RN6	Monooxygenase
Tbis_0829	ENOG4105VCH	membrane
Tbis_0833	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
Tbis_0838	ENOG4105ETE	Transcriptional regulator (LacI family
Tbis_0842	ENOG4107T3P	ABC, transporter
Tbis_0843	ENOG4108RZ2	Glycoside hydrolase family 16
Tbis_0845	ENOG4105BZU	Histidine kinase
Tbis_0847	ENOG4108EMS	branched-chain alpha-keto acid dehydrogenase subunit E2
Tbis_0850	ENOG4105CVR	type I restriction-modification system
Tbis_0856	ENOG4107TE1	transport protein
Tbis_0861	ENOG4105ETE	Transcriptional regulator (LacI family
Tbis_0867	ENOG4105EB1	binding-protein-dependent transport systems inner membrane Component
Tbis_0868	ENOG4105S9S	Binding-protein-dependent transport systems, inner membrane component
Tbis_0869	ENOG4105EPJ	extracellular solute-binding protein family 1
Tbis_0870	ENOG4107T3P	ABC, transporter
Tbis_0872	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
Tbis_0874	ENOG4105CG3	alpha amylase, catalytic region
Tbis_0878	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
Tbis_0879	ENOG4105D6E	homoserine dehydrogenase
Tbis_0882	ENOG4108SHN	Glycosyl transferase, family 2
Tbis_0884	ENOG4107R5I	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
Tbis_0885	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
Tbis_0887	ENOG4105VFB	Binds the 23S rRNA (By similarity)
Tbis_0888	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
Tbis_0889	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
Tbis_0895	ENOG4105ZA1	atp synthase
Tbis_0896	ENOG4107Z0K	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
Tbis_0897	ENOG4108T62	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
Tbis_0898	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
Tbis_0899	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
Tbis_0900	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
Tbis_0901	ENOG410825K	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
Tbis_0904	ENOG4108IUX	(ABC) transporter
Tbis_0905	ENOG4105RHA	ABC transporter, permease
Tbis_0906	ENOG4105BZU	Histidine kinase
Tbis_0907	ENOG4108S01	response regulator
Tbis_0911	ENOG4105CYV	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity)
Tbis_0914	ENOG41074FZ	May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity)
Tbis_0917	ENOG4105CHU	acetyl-coa acetyltransferase
Tbis_0924	ENOG4108UJU	UPF0301 protein
Tbis_0932	ENOG4108RWI	nicotinamidase
Tbis_0934	ENOG4105KEN	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
Tbis_0935	ENOG4108Q7D	Domain of unknown function (DUF2017)
Tbis_0940	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
Tbis_0941	ENOG4108RQ5	Beta-lactamase domain-containing protein
Tbis_0942	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
Tbis_0943	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
Tbis_0947	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
Tbis_0949	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Tbis_0950	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Tbis_0951	ENOG4105WH1	Two component transcriptional regulator luxr family
Tbis_0952	ENOG4105BZU	Histidine kinase
Tbis_0960	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
Tbis_0961	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
Tbis_0966	ENOG4105CI2	imidazolone-5-propionate hydrolase
Tbis_0971	ENOG4105GWZ	Roadblock lc7 family protein
Tbis_0974	ENOG4105BZU	Histidine kinase
Tbis_0975	ENOG4105GWZ	Roadblock lc7 family protein
Tbis_0979	ENOG4105K5M	30s ribosomal protein S16
Tbis_0980	ENOG41082KU	UPF0109 protein
Tbis_0981	ENOG4107XUM	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
Tbis_0982	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
Tbis_0983	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
Tbis_0986	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
Tbis_0989	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
Tbis_0991	ENOG4105C0P	Mg chelatase subunit ChlI
Tbis_0992	ENOG41080R2	UPF0102 protein
Tbis_0994	ENOG4105CE9	30S ribosomal protein S2
Tbis_0995	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
Tbis_0996	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
Tbis_0997	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
Tbis_0998	ENOG4105KNE	Phosphatidate cytidylyltransferase
Tbis_1000	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
Tbis_1008	ENOG4105C26	Dehydrogenase
Tbis_1009	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
Tbis_1011	ENOG4105F38	ABC transporter, permease
Tbis_1012	ENOG4105D38	putrescine abc transporter
Tbis_1013	ENOG4105CJP	fad dependent oxidoreductase
Tbis_1014	ENOG41082YX	Transcriptional regulator, arsr family
Tbis_1017	ENOG4105CHR	reductase
Tbis_1018	ENOG4108NIW	Leucine export protein LeuE
Tbis_1022	ENOG4106UDK	Cellulose-binding, family II
Tbis_1025	ENOG4105DSF	transport protein
Tbis_1030	ENOG4108JPW	Aminotransferase
Tbis_1032	ENOG4107TYH	extracellular solute-binding protein family 1
Tbis_1041	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
Tbis_1044	ENOG4108IG5	Transcriptional regulator
Tbis_1045	ENOG4105EYF	MMPL domain protein
Tbis_1050	ENOG4105CHR	reductase
Tbis_1051	ENOG4105FDP	GntR family transcriptional regulator
Tbis_1055	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
Tbis_1058	ENOG4107Z1I	Required for maturation of 30S ribosomal subunits (By similarity)
Tbis_1061	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
Tbis_1063	ENOG4107ZPY	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
Tbis_1064	ENOG4105SFS	phosphoesterase RecJ domain protein
Tbis_1065	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
Tbis_1067	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
Tbis_1068	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
Tbis_1069	ENOG4105C1V	Peptidase, M16
Tbis_1070	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
Tbis_1074	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
Tbis_1076	ENOG4105FDP	GntR family transcriptional regulator
Tbis_1077	ENOG4105W5Q	DNA repair protein (RadC
Tbis_1080	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
Tbis_1081	ENOG4105CN5	Metallo-Beta-Lactamase
Tbis_1083	ENOG4105EQX	glucarate dehydratase
Tbis_1085	ENOG4105E9Z	Nad-dependent epimerase dehydratase
Tbis_1087	ENOG4108J20	pectate lyase
Tbis_1089	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
Tbis_1091	ENOG4105CXK	mandelate racemase muconate lactonizing
Tbis_1092	ENOG4105J4Q	Transcriptional regulator
Tbis_1095	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
Tbis_1097	ENOG4105CEV	competence damage-inducible protein
Tbis_1098	ENOG4105WBV	Transcriptional regulator
Tbis_1099	ENOG4108S0J	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity)
Tbis_1101	ENOG41066F8	ROK family
Tbis_1102	ENOG4105D17	glycoside hydrolase, family 3 domain protein
Tbis_1104	ENOG4105D56	permease protein
Tbis_1113	ENOG4107QRT	dEAD DEAH box helicase
Tbis_1115	ENOG4108IUX	(ABC) transporter
Tbis_1116	ENOG4105RHA	ABC transporter, permease
Tbis_1118	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
Tbis_1119	ENOG4105KC9	Modulates RecA activity (By similarity)
Tbis_1120	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
Tbis_1122	ENOG4105DRP	amino acid AbC transporter
Tbis_1123	ENOG4108Q1T	ABC transporter
Tbis_1124	ENOG4107UBR	Extracellular solute-binding protein family 3
Tbis_1125	ENOG4105CDA	abc transporter atp-binding protein
Tbis_1126	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
Tbis_1128	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
Tbis_1130	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
Tbis_1131	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
Tbis_1136	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
Tbis_1137	ENOG4105CQB	FAD linked oxidase domain protein
Tbis_1138	ENOG4105CQB	FAD linked oxidase domain protein
Tbis_1139	ENOG4107R9S	Malate synthase
Tbis_1140	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
Tbis_1142	ENOG4105KQC	Competence protein
Tbis_1145	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
Tbis_1146	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
Tbis_1147	ENOG4108RPX	mosc domain containing protein
Tbis_1150	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
Tbis_1151	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
Tbis_1155	ENOG4107YU2	histidine triad (hIT) protein
Tbis_1157	ENOG4107VNR	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
Tbis_1162	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
Tbis_1165	ENOG4107QXN	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
Tbis_1168	ENOG4105C8Y	Acetylornithine aminotransferase
Tbis_1169	ENOG4105CIK	Amidinotransferase
Tbis_1170	ENOG4105F7P	transcriptional regulator AsnC family
Tbis_1171	ENOG4105DUM	transcriptional regulator, lysR family
Tbis_1176	ENOG4106DBE	Involved in DNA repair and RecF pathway recombination (By similarity)
Tbis_1177	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
Tbis_1182	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
Tbis_1184	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
Tbis_1185	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
Tbis_1187	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
Tbis_1188	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Tbis_1191	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
Tbis_1192	ENOG4105FDP	GntR family transcriptional regulator
Tbis_1194	ENOG4105C2J	ABC transporter
Tbis_1197	ENOG41061GT	Aldolase
Tbis_1199	ENOG4105CMG	Carbohydrate kinase
Tbis_1205	ENOG4105CZV	ABC transporter
Tbis_1206	ENOG4105FDP	GntR family transcriptional regulator
Tbis_1207	ENOG4105CHR	reductase
Tbis_1209	ENOG4105M4P	Tetr family transcriptional regulator
Tbis_1214	ENOG41080RH	Thioredoxin
Tbis_1215	ENOG4105C5X	domain protein
Tbis_1221	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
Tbis_1223	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
Tbis_1231	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
Tbis_1232	ENOG4105EHG	Permease protein
Tbis_1233	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
Tbis_1236	ENOG4105C5W	Aldolase
Tbis_1240	ENOG4105CE2	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding
Tbis_1249	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
Tbis_1251	ENOG4105C57	major facilitator superfamily
Tbis_1252	ENOG4108JGH	Tetr family transcriptional regulator
Tbis_1253	ENOG4105C4K	Nad synthetase
Tbis_1254	ENOG4108IG5	Transcriptional regulator
Tbis_1256	ENOG4107RDB	Major Facilitator
Tbis_1258	ENOG4105C5F	glutamine synthetase
Tbis_1260	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
Tbis_1261	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
Tbis_1262	ENOG4105C5F	glutamine synthetase
Tbis_1264	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
Tbis_1266	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
Tbis_1267	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
Tbis_1268	ENOG4105EC3	peptidase S51, dipeptidase E
Tbis_1271	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
Tbis_1272	ENOG4107SQD	Transcriptional regulator, GntR family
Tbis_1275	ENOG410813T	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
Tbis_1276	ENOG4108YZT	Adenosylcobinamide kinase
Tbis_1278	ENOG4105CPC	Aldo Keto reductase
Tbis_1282	ENOG4105D0M	Protease HtpX homolog
Tbis_1284	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
Tbis_1288	ENOG4105C3J	Cysteine desulfurase
Tbis_1289	ENOG4105CV4	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity)
Tbis_1290	ENOG4105BZ9	Cytochrome C oxidase, subunit I
Tbis_1291	ENOG4105MCD	Part of cytochrome c oxidase, its function is
Tbis_1293	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
Tbis_1294	ENOG4107EUI	c reductase, iron-sulfur
Tbis_1296	ENOG4105CCU	oxidase (Subunit III)
Tbis_1298	ENOG4107S1N	anthranilate phosphoribosyltransferase
Tbis_1308	ENOG4105DKQ	ROK family
Tbis_1313	ENOG4105F6E	Acyl-transferase
Tbis_1315	ENOG4108J5H	Homocysteine s-methyltransferase
Tbis_1322	ENOG4106FTQ	Taurine ABC transporter, periplasmic
Tbis_1323	ENOG4105EUS	Binding-protein-dependent transport systems, inner membrane component
Tbis_1324	ENOG4105FBW	Monooxygenase
Tbis_1325	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
Tbis_1326	ENOG4105CTQ	phosphohexokinase
Tbis_1327	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
Tbis_1328	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
Tbis_1329	ENOG4108HRK	Histidine kinase
Tbis_1330	ENOG4108NEV	two component transcriptional regulator, LytTR family
Tbis_1331	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
Tbis_1336	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
Tbis_1338	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
Tbis_1340	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
Tbis_1342	ENOG4105KYH	transcriptional regulatory protein
Tbis_1343	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
Tbis_1348	ENOG4108E1C	hydrolase
Tbis_1351	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
Tbis_1352	ENOG4105CXT	aspartate transcarbamylase
Tbis_1353	ENOG4105CD3	dihydroorotase
Tbis_1354	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
Tbis_1355	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
Tbis_1356	ENOG4105DF0	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity)
Tbis_1357	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
Tbis_1358	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
Tbis_1360	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
Tbis_1361	ENOG4105MTQ	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
Tbis_1363	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
Tbis_1367	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
Tbis_1368	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
Tbis_1370	ENOG4105DJV	ribulose-phosphate 3-epimerase
Tbis_1371	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
Tbis_1374	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
Tbis_1375	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
Tbis_1378	ENOG4105GVF	(ABC) transporter
Tbis_1379	ENOG4105E2Y	ABC, transporter
Tbis_1380	ENOG4105EFS	Binding-protein-dependent transport systems, inner membrane component
Tbis_1388	ENOG4105DYW	oxidoreductase
Tbis_1390	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
Tbis_1391	ENOG410803B	Involved in the transcription termination process (By similarity)
Tbis_1393	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
Tbis_1397	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
Tbis_1398	ENOG4108V6E	Cell division protein mraZ
Tbis_1399	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
Tbis_1401	ENOG4105CJN	penicillin-binding protein
Tbis_1402	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
Tbis_1404	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
Tbis_1405	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
Tbis_1407	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
Tbis_1408	ENOG4105DFU	Cell wall formation (By similarity)
Tbis_1409	ENOG4105ME9	cell division protein FtsQ
Tbis_1410	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
Tbis_1412	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
Tbis_1416	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
Tbis_1417	ENOG410856B	UPF0235 protein
Tbis_1419	ENOG4107ZIW	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
Tbis_1422	ENOG4105C4R	Atp-dependent dna helicase
Tbis_1425	ENOG4105C0B	DNA polymerase III (alpha subunit)
Tbis_1426	ENOG4105BZ4	penicillin-binding protein
Tbis_1428	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
Tbis_1430	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
Tbis_1431	ENOG4108Z66	YbaK ebsC protein
Tbis_1434	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
Tbis_1435	ENOG4105CIH	Imidazole acetol-phosphate transaminase
Tbis_1436	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
Tbis_1437	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
Tbis_1438	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Tbis_1439	ENOG4108176	endoribonuclease L-psp
Tbis_1440	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
Tbis_1445	ENOG4105BZ1	(ABC) transporter
Tbis_1446	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
Tbis_1450	ENOG4105DK0	Indole-3-glycerol phosphate synthase
Tbis_1451	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
Tbis_1452	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
Tbis_1455	ENOG4107TBN	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
Tbis_1458	ENOG4105CBC	glutamate synthase
Tbis_1464	ENOG4105C32	Amino acid ABC transporter (Permease)
Tbis_1465	ENOG4105C0Z	ABC transporter
Tbis_1466	ENOG4108IV0	ABC, transporter
Tbis_1469	ENOG4105CP9	extracellular ligand-binding receptor
Tbis_1470	ENOG4105C32	Amino acid ABC transporter (Permease)
Tbis_1471	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
Tbis_1472	ENOG4105C0Z	ABC transporter
Tbis_1473	ENOG4108IV0	ABC, transporter
Tbis_1474	ENOG4108TZA	Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity)
Tbis_1477	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
Tbis_1479	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
Tbis_1485	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
Tbis_1486	ENOG4108UW5	maltose o-acetyltransferase
Tbis_1487	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
Tbis_1491	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
Tbis_1492	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
Tbis_1496	ENOG4105CAT	Cytidine monophosphate kinase
Tbis_1497	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
Tbis_1510	ENOG4105C26	Dehydrogenase
Tbis_1513	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
Tbis_1523	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
Tbis_1530	ENOG4105TZK	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
Tbis_1538	ENOG4107QN1	sodium solute
Tbis_1540	ENOG4105CFG	Acts as a chaperone (By similarity)
Tbis_1550	ENOG4105CUB	amino acid
Tbis_1552	ENOG4105CQM	Urea amidohydrolase subunit alpha
Tbis_1554	ENOG4107P2S	Transcriptional regulator
Tbis_1555	ENOG4105GVF	(ABC) transporter
Tbis_1556	ENOG4105EFS	Binding-protein-dependent transport systems, inner membrane component
Tbis_1557	ENOG4105E2Y	ABC, transporter
Tbis_1558	ENOG4105CPU	Monooxygenase
Tbis_1561	ENOG4105E0S	extracellular solute-binding protein family 1
Tbis_1562	ENOG4105C50	Binding-protein-dependent transport systems, inner membrane component
Tbis_1572	ENOG4105D22	carbon starvation protein
Tbis_1575	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
Tbis_1583	ENOG4105C7K	acetolactate synthase
Tbis_1584	ENOG4105K6S	Short-chain dehydrogenase reductase Sdr
Tbis_1585	ENOG4105CD5	CoA-binding domain protein
Tbis_1586	ENOG4105C1G	acyl-Coa dehydrogenase
Tbis_1587	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
Tbis_1588	ENOG4105D38	putrescine abc transporter
Tbis_1589	ENOG4105F38	ABC transporter, permease
Tbis_1592	ENOG4105CPU	Monooxygenase
Tbis_1593	ENOG4105CPU	Monooxygenase
Tbis_1595	ENOG4105DEN	Luciferase family
Tbis_1597	ENOG4107QV8	Conserved hypothetical protein 698
Tbis_1601	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Tbis_1603	ENOG41065RQ	ADP-ribosylation crystallin J1
Tbis_1604	ENOG4105CEY	Amp-dependent synthetase and ligase
Tbis_1606	ENOG4108UZX	fmn reductase
Tbis_1608	ENOG4105CHR	reductase
Tbis_1610	ENOG4105CHR	reductase
Tbis_1613	ENOG4105CSH	Transporter
Tbis_1618	ENOG4105D5P	Methylmalonyl-coA mutase
Tbis_1619	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
Tbis_1621	ENOG4105E0A	ABC, transporter
Tbis_1622	ENOG4105TVJ	transport system, permease
Tbis_1623	ENOG4105DQ5	transport system permease protein
Tbis_1628	ENOG4105MXW	flavin reductase domain protein, FMN-binding
Tbis_1629	ENOG4105C3D	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
Tbis_1633	ENOG4108KC1	acyl-Coa dehydrogenase
Tbis_1634	ENOG4108SGK	Tetr family transcriptional regulator
Tbis_1638	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
Tbis_1648	ENOG4105C59	p-type ATPase
Tbis_1652	ENOG4107STQ	Multicopper oxidase
Tbis_1658	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Tbis_1660	ENOG4108JQ7	(ABC) transporter
Tbis_1662	ENOG4105EHZ	conserved protein UCP016719
Tbis_1663	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
Tbis_1664	ENOG4107S1E	Beta-lactamase
Tbis_1668	ENOG4105Y7X	Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity)
Tbis_1669	ENOG4105CHF	Glutathione S-transferase
Tbis_1673	ENOG4108REK	sugar kinase
Tbis_1679	ENOG4105CGP	Urocanate hydratase
Tbis_1680	ENOG4105BZM	domain protein
Tbis_1684	ENOG4105CNI	cell division protein FtsW
Tbis_1685	ENOG4105CJN	penicillin-binding protein
Tbis_1686	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
Tbis_1693	ENOG4108UW8	fha domain-containing protein
Tbis_1697	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Tbis_1707	ENOG4108IPT	Naphthoate synthase
Tbis_1708	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
Tbis_1710	ENOG4105FDP	GntR family transcriptional regulator
Tbis_1712	ENOG41062B0	ABC transporter, permease
Tbis_1715	ENOG4108JJ9	ABC, transporter
Tbis_1716	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
Tbis_1717	ENOG4105E4F	Isochorismate synthase
Tbis_1721	ENOG4105BZU	Histidine kinase
Tbis_1723	ENOG4108M15	ABC transporter
Tbis_1724	ENOG4108I69	Glycosyl transferases group 1
Tbis_1727	ENOG4108JQC	penicillin-binding protein 1A
Tbis_1729	ENOG4105Y3U	Transglycosylase-associated protein
Tbis_1731	ENOG4105FDR	Membrane
Tbis_1740	ENOG4108Z86	Glutamine amidotransferase
Tbis_1741	ENOG4105C26	Dehydrogenase
Tbis_1742	ENOG4108Z86	Glutamine amidotransferase
Tbis_1745	ENOG4105C1G	acyl-Coa dehydrogenase
Tbis_1746	ENOG4105C3M	thioredoxin reductase
Tbis_1749	ENOG4107RUY	(E1 component), alpha subunit
Tbis_1750	ENOG4105CPP	Dehydrogenase, E1 component
Tbis_1751	ENOG4105C7S	Dehydrogenase
Tbis_1752	ENOG4107S91	Sodium hydrogen exchanger
Tbis_1757	ENOG4105C7H	Helicase, RecD TraA family
Tbis_1762	ENOG410814C	multidrug resistance protein
Tbis_1763	ENOG4108MHR	Repressor involved in choline regulation of the bet genes (By similarity)
Tbis_1764	ENOG4105HAC	ABC-2 type transporter
Tbis_1766	ENOG4105CJ1	ABC, transporter
Tbis_1769	ENOG4108MRH	transcriptional regulatory protein
Tbis_1770	ENOG4105CSH	Transporter
Tbis_1771	ENOG4105WH1	Two component transcriptional regulator luxr family
Tbis_1775	ENOG4105C8Y	Acetylornithine aminotransferase
Tbis_1780	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
Tbis_1781	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
Tbis_1783	ENOG4105C83	adenylosuccinate lyase
Tbis_1792	ENOG4106UW1	Major Facilitator superfamily
Tbis_1795	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
Tbis_1798	ENOG4107Y49	methyltransferase
Tbis_1800	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
Tbis_1802	ENOG4105CHU	acetyl-coa acetyltransferase
Tbis_1803	ENOG4107RSM	transcriptional regulator
Tbis_1804	ENOG4105C1G	acyl-Coa dehydrogenase
Tbis_1805	ENOG4105Q70	
Tbis_1807	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
Tbis_1813	ENOG4105EW9	transcriptional regulator AsnC family
Tbis_1814	ENOG4105C1G	acyl-Coa dehydrogenase
Tbis_1819	ENOG4105HFS	5'-3' exonuclease
Tbis_1822	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
Tbis_1823	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
Tbis_1828	ENOG41081K0	peptidylprolyl cis-trans isomerase
Tbis_1829	ENOG4105DVV	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity)
Tbis_1831	ENOG4105F7N	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
Tbis_1832	ENOG4105KPK	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
Tbis_1833	ENOG4105EP9	oxidoreductase
Tbis_1835	ENOG4105WFD	Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity)
Tbis_1836	ENOG4105E5F	proteasome
Tbis_1838	ENOG4105DHM	ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity)
Tbis_1840	ENOG4105D9U	N-acetyltransferase
Tbis_1845	ENOG4105BZU	Histidine kinase
Tbis_1846	ENOG4105WH1	Two component transcriptional regulator luxr family
Tbis_1847	ENOG4108JQ7	(ABC) transporter
Tbis_1851	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Tbis_1853	ENOG4107UW8	HAD-superfamily hydrolase subfamily IA variant 3
Tbis_1854	ENOG4105C3R	Methionine synthase
Tbis_1860	ENOG4105DF0	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity)
Tbis_1863	ENOG4105C3Q	Glycosyl transferase, family 2
Tbis_1875	ENOG4105DUM	transcriptional regulator, lysR family
Tbis_1883	ENOG4105CG3	alpha amylase, catalytic region
Tbis_1884	ENOG4105EG2	ABC transporter, permease
Tbis_1889	ENOG4105E0F	Histidine kinase
Tbis_1890	ENOG4105CBG	Sulfatase
Tbis_1893	ENOG4105DRS	transport system, permease
Tbis_1895	ENOG4105ETE	Transcriptional regulator (LacI family
Tbis_1897	ENOG4107WI4	Aldose-1-epimerase
Tbis_1898	ENOG4107RQD	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity)
Tbis_1899	ENOG4105C7V	phospho-2-dehydro-3-deoxyheptonate aldolase
Tbis_1901	ENOG4105BZ9	Cytochrome C oxidase, subunit I
Tbis_1902	ENOG4108YV4	Universal stress protein
Tbis_1904	ENOG4105C0H	protease
Tbis_1906	ENOG4105D01	(LipO)protein
Tbis_1907	ENOG4108UMI	ABC transporter, permease
Tbis_1908	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
Tbis_1910	ENOG4105DGI	Alkaline phosphatase
Tbis_1915	ENOG410650H	(LipO)protein
Tbis_1916	ENOG4105DBE	peroxidase
Tbis_1922	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
Tbis_1932	ENOG4105C8N	cysteinyl-tRNA synthetase
Tbis_1937	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
Tbis_1938	ENOG4105CPC	Aldo Keto reductase
Tbis_1940	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
Tbis_1941	ENOG4105CHR	reductase
Tbis_1944	ENOG4105WKW	Pfam:DUF1458
Tbis_1946	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
Tbis_1947	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
Tbis_1954	ENOG4105DUX	Transporter
Tbis_1955	ENOG4105BZP	glycoside hydrolase 15-related
Tbis_1956	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
Tbis_1958	ENOG4105BZ1	(ABC) transporter
Tbis_1961	ENOG4105C5H	ABC transporter
Tbis_1963	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
Tbis_1964	ENOG4105M0N	phosphoribosyl-ATP pyrophosphatase
Tbis_1965	ENOG4105I82	acetyl xylan esterase
Tbis_1966	ENOG4105VG1	fes assembly suf system protein
Tbis_1967	ENOG4108UNV	SUF system FeS assembly protein, NifU family
Tbis_1968	ENOG4105C9B	Cysteine desulfurase
Tbis_1969	ENOG4105C3K	feS assembly ATPase SufC
Tbis_1971	ENOG4105JRK	feS assembly protein SufD
Tbis_1974	ENOG4105CJ1	ABC, transporter
Tbis_1976	ENOG4107AQZ	Membrane
Tbis_1979	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
Tbis_1981	ENOG4107QQX	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
Tbis_1982	ENOG4107QYV	phosphohexose isomerase
Tbis_1985	ENOG4107XU2	6-phosphogluconolactonase (EC 3.1.1.31)
Tbis_1986	ENOG410870F	Cyclic nucleotide-binding protein
Tbis_1988	ENOG4105CD3	dihydroorotase
Tbis_1991	ENOG4105CP7	Triose-phosphate isomerase
Tbis_1992	ENOG4105BZA	Phosphoglycerate kinase
Tbis_1993	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
Tbis_1994	ENOG4105CIE	May be required for sporulation (By similarity)
Tbis_1996	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
Tbis_1997	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
Tbis_1999	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
Tbis_2001	ENOG4105DTQ	mandelate racemase muconate lactonizing
Tbis_2004	ENOG41071I4	Phosphatidylserine decarboxylase proenzyme
Tbis_2006	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
Tbis_2011	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
Tbis_2012	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
Tbis_2016	ENOG4105DSU	hydrolase
Tbis_2021	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
Tbis_2022	ENOG4105CX8	fg-gap repeat protein
Tbis_2023	ENOG4108VX5	3-methyladenine DNA glycosylase
Tbis_2024	ENOG4105CH7	arginosuccinase
Tbis_2025	ENOG4105CDH	Citrulline--aspartate ligase
Tbis_2026	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
Tbis_2027	ENOG4105DBV	ornithine carbamoyltransferase
Tbis_2028	ENOG4105C8Y	Acetylornithine aminotransferase
Tbis_2029	ENOG4105CAS	nag kinase
Tbis_2030	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
Tbis_2031	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
Tbis_2032	ENOG4105CEY	Amp-dependent synthetase and ligase
Tbis_2036	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
Tbis_2037	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
Tbis_2038	ENOG4105BZU	Histidine kinase
Tbis_2039	ENOG4108RWN	rrna methyltransferase
Tbis_2040	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
Tbis_2042	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
Tbis_2043	ENOG4105E2X	shikimate dehydrogenase
Tbis_2044	ENOG4105HHA	aminodeoxychorismate lyase
Tbis_2046	ENOG41080G3	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
Tbis_2047	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
Tbis_2052	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
Tbis_2053	ENOG4105C9M	aspartyl-trna synthetase
Tbis_2054	ENOG4105CUT	histidyl-tRNA synthetase
Tbis_2056	ENOG4108ZR3	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity)
Tbis_2057	ENOG4105C99	atpase involved in dna repair
Tbis_2058	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
Tbis_2059	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
Tbis_2060	ENOG4107RTU	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
Tbis_2061	ENOG4107RSV	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
Tbis_2062	ENOG4105ZCJ	preprotein translocase subunit yajC
Tbis_2063	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
Tbis_2064	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
Tbis_2065	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
Tbis_2066	ENOG4105CDY	transcriptional regulatory protein
Tbis_2067	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
Tbis_2069	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
Tbis_2072	ENOG4105E2K	Glycosyl transferase (Group 1
Tbis_2073	ENOG4107YQ3	lipid a biosynthesis lauroyl acyltransferase
Tbis_2076	ENOG4105F32	YngK protein
Tbis_2078	ENOG4105C22	threonyL-tRNA synthetase
Tbis_2079	ENOG4107SET	aldo keto reductase
Tbis_2083	ENOG4105CEY	Amp-dependent synthetase and ligase
Tbis_2086	ENOG4108KTS	Acetyltransferase and hydrolase with the alpha beta hydrolase fold
Tbis_2089	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
Tbis_2090	ENOG4105E39	Enoyl-CoA hydratase
Tbis_2091	ENOG4105C1G	acyl-Coa dehydrogenase
Tbis_2092	ENOG4105IYB	L-carnitine dehydratase bile acid-inducible protein F
Tbis_2093	ENOG4105C1G	acyl-Coa dehydrogenase
Tbis_2095	ENOG4105KF0	sporulation and cell division protein, SsgA
Tbis_2096	ENOG4107Z5F	Aminotransferase class IV
Tbis_2098	ENOG41080UQ	Transcriptional regulator
Tbis_2100	ENOG4105C84	Histidine ammonia-lyase
Tbis_2102	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
Tbis_2104	ENOG4108IG5	Transcriptional regulator
Tbis_2107	ENOG4105BZU	Histidine kinase
Tbis_2110	ENOG4106A3M	Cytochrome p-450
Tbis_2111	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
Tbis_2112	ENOG4107QPH	glycogen) synthase
Tbis_2113	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
Tbis_2118	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
Tbis_2122	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
Tbis_2125	ENOG4107R37	Glutamate dehydrogenase
Tbis_2126	ENOG4105DCG	PHP domain protein
Tbis_2129	ENOG4107QN1	sodium solute
Tbis_2133	ENOG4108NEV	two component transcriptional regulator, LytTR family
Tbis_2134	ENOG4108HRK	Histidine kinase
Tbis_2138	ENOG4105CYP	glycoside hydrolase, family
Tbis_2141	ENOG4109050	May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG)
Tbis_2143	ENOG4105CQB	FAD linked oxidase domain protein
Tbis_2144	ENOG4105CGU	Enoyl-CoA hydratase
Tbis_2147	ENOG4105D53	Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity)
Tbis_2151	ENOG4105C1G	acyl-Coa dehydrogenase
Tbis_2152	ENOG4105CBH	Hydroxymethylglutaryl-CoA lyase
Tbis_2154	ENOG4107QX3	carboxylase
Tbis_2156	ENOG4105CPP	Dehydrogenase, E1 component
Tbis_2166	ENOG4105EYH	Exonuclease
Tbis_2167	ENOG4107RH8	nuclease SbcCD subunit D
Tbis_2169	ENOG4108KGH	TRANSCRIPTIONal
Tbis_2170	ENOG4105DTQ	mandelate racemase muconate lactonizing
Tbis_2171	ENOG4105DEG	Vwa containing coxe family protein
Tbis_2173	ENOG4105KKX	ATPase associated with various cellular activities aaa_5
Tbis_2176	ENOG4105C26	Dehydrogenase
Tbis_2199	ENOG4105ETE	Transcriptional regulator (LacI family
Tbis_2207	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
Tbis_2208	ENOG4105D49	3-dehydroquinate synthase
Tbis_2209	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
Tbis_2210	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
Tbis_2213	ENOG4105CWN	amidohydrolase
Tbis_2214	ENOG4105C5B	carbamate kinase
Tbis_2215	ENOG4108X7C	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity)
Tbis_2216	ENOG4105D3R	alkyl hydroperoxide reductase
Tbis_2219	ENOG4107QPI	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
Tbis_2231	ENOG4105C2W	permease
Tbis_2233	ENOG4105G5A	Protein of unknown function (DUF2877)
Tbis_2234	ENOG4107R1Q	Membrane protein FdrA
Tbis_2235	ENOG4107REC	cytoplasmic protein
Tbis_2236	ENOG4105D9P	serine threonine protein kinase
Tbis_2241	ENOG4105WBQ	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity)
Tbis_2242	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
Tbis_2244	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
Tbis_2246	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
Tbis_2251	ENOG4105CSU	acyl-Coa dehydrogenase
Tbis_2259	ENOG4105E0X	reductase
Tbis_2261	ENOG4107JTW	chlorite dismutase
Tbis_2262	ENOG4105C1Q	protoporphyrinogen oxidase
Tbis_2264	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
Tbis_2266	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
Tbis_2267	ENOG4105CHU	acetyl-coa acetyltransferase
Tbis_2268	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
Tbis_2269	ENOG4105CUB	amino acid
Tbis_2270	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
Tbis_2271	ENOG4105E2R	ROK family
Tbis_2272	ENOG4107RNG	ABC transporter
Tbis_2273	ENOG4105C2J	ABC transporter
Tbis_2276	ENOG4107QM5	aconitate hydratase
Tbis_2283	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
Tbis_2284	ENOG4105C0X	amino acid
Tbis_2285	ENOG4107VEG	TrkA-N domain protein
Tbis_2290	ENOG4107ZFB	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
Tbis_2292	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
Tbis_2294	ENOG4105C1K	alpha-alpha-trehalose-phosphate synthase
Tbis_2297	ENOG4106F60	Histidine kinase
Tbis_2298	ENOG4105F44	Two component transcriptional regulator, winged helix family
Tbis_2301	ENOG4107QME	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
Tbis_2302	ENOG4105FAA	peptidase M23
Tbis_2308	ENOG4107VBM	3-beta hydroxysteroid dehydrogenase isomerase
Tbis_2311	ENOG4105CVJ	phosphoglycerate mutase
Tbis_2313	ENOG4105EGD	dinuclear metal center protein, YbgI family
Tbis_2314	ENOG41062D9	Histidine kinase
Tbis_2316	ENOG4105URP	P-aminobenzoate N-oxygenase AurF
Tbis_2317	ENOG4105E0T	Short-chain dehydrogenase reductase Sdr
Tbis_2319	ENOG4106R7G	Glycoside hydrolase family 5
Tbis_2320	ENOG4105ETE	Transcriptional regulator (LacI family
Tbis_2325	ENOG4105JXB	ankyrin repeat-containing protein
Tbis_2330	ENOG4105CQ7	ATP-dependent helicase
Tbis_2331	ENOG4107NHD	transcriptional regulator
Tbis_2348	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
Tbis_2351	ENOG4105CEI	nitrite reductase
Tbis_2360	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
Tbis_2364	ENOG4105P3N	Membrane
Tbis_2370	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
Tbis_2371	ENOG41082KT	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
Tbis_2381	ENOG4105KHC	sulfurtransferase
Tbis_2385	ENOG4107Y7Q	pfkb domain protein
Tbis_2387	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
Tbis_2394	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
Tbis_2398	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Tbis_2398	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Tbis_2401	ENOG4105E7W	lamb ycsf family protein
Tbis_2405	ENOG4105ETE	Transcriptional regulator (LacI family
Tbis_2407	ENOG4105E2R	ROK family
Tbis_2412	ENOG4107QK4	glycoside hydrolase, family 3 domain protein
Tbis_2416	ENOG4105CJQ	hydrolase, family 31
Tbis_2425	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
Tbis_2426	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
Tbis_2427	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
Tbis_2428	ENOG4105C87	Aminotransferase class I and II
Tbis_2429	ENOG4105C8T	Leucyl-tRNA synthetase
Tbis_2432	ENOG4105CEY	Amp-dependent synthetase and ligase
Tbis_2433	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
Tbis_2438	ENOG4107RYT	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity)
Tbis_2442	ENOG4105EXN	Sulfate transport protein CysZ
Tbis_2443	ENOG4107WR6	Maf-like protein
Tbis_2446	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
Tbis_2447	ENOG4108R85	Short chain dehydrogenase
Tbis_2453	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
Tbis_2454	ENOG4105D0M	Protease HtpX homolog
Tbis_2456	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
Tbis_2457	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
Tbis_2458	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Tbis_2459	ENOG4105K46	50S ribosomal protein l27
Tbis_2460	ENOG410826X	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
Tbis_2461	ENOG4105C03	ribonuclease
Tbis_2464	ENOG4105CNI	cell division protein FtsW
Tbis_2465	ENOG4105CJN	penicillin-binding protein
Tbis_2468	ENOG4105DFF	Rod shape-determining protein mreb
Tbis_2469	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
Tbis_2472	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
Tbis_2474	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
Tbis_2475	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
Tbis_2476	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
Tbis_2477	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
Tbis_2478	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
Tbis_2482	ENOG4105GFG	DUF218 domain
Tbis_2490	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
Tbis_2491	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
Tbis_2495	ENOG4105CTK	cobaltochelatase, cobn subunit
Tbis_2502	ENOG4105CX4	Precorrin-6y C5,15-methyltransferase
Tbis_2505	ENOG4105VTR	Integrase
Tbis_2507	ENOG4105DZR	Type I site-specific deoxyribonuclease
Tbis_2509	ENOG4105CVR	type I restriction-modification system
Tbis_2515	ENOG4105CEY	Amp-dependent synthetase and ligase
Tbis_2517	ENOG4105MXW	flavin reductase domain protein, FMN-binding
Tbis_2524	ENOG4105CHR	reductase
Tbis_2528	ENOG4105DZP	Membrane-associated zinc metalloprotease
Tbis_2532	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
Tbis_2538	ENOG4105C01	Dihydroxy-acid dehydratase
Tbis_2549	ENOG4105D8X	mechanosensitive ion channel
Tbis_2556	ENOG4108Z6B	deaminase
Tbis_2558	ENOG4108UUM	single-stranded DNA-binding protein
Tbis_2561	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
Tbis_2562	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
Tbis_2563	ENOG4105DAT	cobalamin (vitamin b12) biosynthesis cbix protein
Tbis_2567	ENOG4105CR8	Transcriptional regulator
Tbis_2568	ENOG4105CHM	Aminotransferase
Tbis_2570	ENOG4105C0B	DNA polymerase III (alpha subunit)
Tbis_2572	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
Tbis_2573	ENOG4107R95	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
Tbis_2576	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
Tbis_2580	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
Tbis_2581	ENOG4105ETE	Transcriptional regulator (LacI family
Tbis_2583	ENOG4105C2J	ABC transporter
Tbis_2584	ENOG4105CNN	ABC, transporter
Tbis_2588	ENOG4108RVA	ribokinase
Tbis_2591	ENOG4105BZW	Glycerate kinase
Tbis_2597	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
Tbis_2600	ENOG4105P4J	Allophanate hydrolase, subunit 1
Tbis_2603	ENOG4105EJQ	L-serine dehydratase
Tbis_2606	ENOG4105C26	Dehydrogenase
Tbis_2607	ENOG4105C7K	acetolactate synthase
Tbis_2608	ENOG4105CSH	Transporter
Tbis_2610	ENOG4105CQM	Urea amidohydrolase subunit alpha
Tbis_2611	ENOG4108YZ9	Urea amidohydrolase subunit gamma
Tbis_2615	ENOG4107P0T	Selenium-dependent molybdenum hydroxylase system protein, YqeB family
Tbis_2617	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
Tbis_2618	ENOG41082MF	Hydrogenase assembly chaperone hypC hupF
Tbis_2619	ENOG4105WMM	Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity)
Tbis_2625	ENOG4105DPX	Hydrogenase, large subunit
Tbis_2628	ENOG4105EMN	RNA polymerase sigma factor
Tbis_2629	ENOG4105WDY	DNA (cytosine-5-)-methyltransferase
Tbis_2633	ENOG4108W9Q	Endoglucanase (EC 3.2.1.4)
Tbis_2636	ENOG4108IAJ	Nad-dependent epimerase dehydratase
Tbis_2639	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
Tbis_2640	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
Tbis_2641	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
Tbis_2642	ENOG4105DKP	glycosyl transferase, family 9
Tbis_2645	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
Tbis_2649	ENOG4108V75	Glutamine amidotransferase
Tbis_2650	ENOG4105E46	N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process
Tbis_2651	ENOG4105D1K	glutamate--cysteine ligase
Tbis_2655	ENOG4105PGM	cation diffusion facilitator family transporter
Tbis_2656	ENOG41065HY	1,4-beta-cellobiosidase
Tbis_2659	ENOG4105D9Z	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
Tbis_2664	ENOG4105C8N	cysteinyl-tRNA synthetase
Tbis_2667	ENOG4108KZ5	Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity)
Tbis_2676	ENOG4107BJW	polysaccharide deacetylase
Tbis_2680	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
Tbis_2681	ENOG4105PFC	Transcriptional regulator
Tbis_2690	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
Tbis_2697	ENOG4105D2B	acyl-CoA dehydrogenase
Tbis_2698	ENOG4105D2B	acyl-CoA dehydrogenase
Tbis_2699	ENOG4105C1G	acyl-Coa dehydrogenase
Tbis_2703	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
Tbis_2705	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
Tbis_2710	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
Tbis_2711	ENOG4105CJW	magnesium transporter
Tbis_2714	ENOG4105EPJ	extracellular solute-binding protein family 1
Tbis_2716	ENOG4105DRS	transport system, permease
Tbis_2728	ENOG41088T4	Helicase IV
Tbis_2729	ENOG4108I5C	dEAD DEAH box helicase
Tbis_2730	ENOG4105BZK	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity)
Tbis_2731	ENOG4105CVR	type I restriction-modification system
Tbis_2732	ENOG4105DXB	Major Facilitator superfamily
Tbis_2734	ENOG4108UMS	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity)
Tbis_2747	ENOG4108JJ8	(ABC) transporter
Tbis_2748	ENOG4108JJ9	ABC, transporter
Tbis_2749	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
Tbis_2750	ENOG4105C4M	(Ubiquinol oxidase) subunit I
Tbis_2754	ENOG4105CJH	Alcohol dehydrogenase zinc-binding domain protein
Tbis_2755	ENOG41082T9	Membrane
Tbis_2757	ENOG4105DJ2	Major Facilitator Superfamily
Tbis_2760	ENOG4107HP6	Transcriptional regulator
Tbis_2761	ENOG4105CPC	Aldo Keto reductase
Tbis_2766	ENOG4105CI3	gtp-binding protein typa
Tbis_2768	ENOG4105D7A	ATP-binding protein
Tbis_2769	ENOG4108ZJ4	polysaccharide deacetylase
Tbis_2772	ENOG4105EMN	RNA polymerase sigma factor
Tbis_2774	ENOG4105D9F	endo-1,4-beta-xylanase (EC 3.2.1.8)
Tbis_2776	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
Tbis_2778	ENOG4108375	Acylphosphatase (EC 3.6.1.7)
Tbis_2779	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
Tbis_2780	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
Tbis_2781	ENOG41084BZ	50S ribosomal protein L32
Tbis_2783	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
Tbis_2784	ENOG4106H78	methyltransferase
Tbis_2786	ENOG4105VB9	50S ribosomal protein l28
Tbis_2787	ENOG4105DWF	phosphomethylpyrimidine kinase
Tbis_2792	ENOG4105CPF	Cell wall formation (By similarity)
Tbis_2793	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
Tbis_2795	ENOG4105ME0	Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor (By similarity)
Tbis_2800	ENOG4105K70	DNA-binding protein
Tbis_2801	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Tbis_2802	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Tbis_2803	ENOG41069M3	Transcriptional regulator
Tbis_2805	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
Tbis_2806	ENOG4105ERH	Fumarylacetoacetate hydrolase
Tbis_2809	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
Tbis_2811	ENOG4105CM2	brancheD-chain amino acid aminotransferase
Tbis_2812	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
Tbis_2814	ENOG4108JQ1	Dehydrogenase
Tbis_2816	ENOG4105CT4	transporter
Tbis_2817	ENOG4105K4I	Scp-like extracellular
Tbis_2819	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
Tbis_2820	ENOG4108ZP8	Acetolactate synthase small subunit
Tbis_2822	ENOG4105BZU	Histidine kinase
Tbis_2823	ENOG4105C5I	Dehydrogenase
Tbis_2826	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
Tbis_2827	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
Tbis_2828	ENOG41081AP	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
Tbis_2829	ENOG4105BZU	Histidine kinase
Tbis_2830	ENOG4108W9Q	Endoglucanase (EC 3.2.1.4)
Tbis_2832	ENOG4108UWZ	4-Carboxymuconolactone decarboxylase
Tbis_2833	ENOG4107RAW	3-carboxy-cis-cis-muconate cycloisomerase
Tbis_2838	ENOG4107HP6	Transcriptional regulator
Tbis_2839	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
Tbis_2841	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
Tbis_2842	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
Tbis_2845	ENOG4105C10	Electron transfer flavoprotein
Tbis_2848	ENOG4108762	serine threonine protein kinase
Tbis_2851	ENOG4108ME1	Peptidase M55 D-aminopeptidase
Tbis_2854	ENOG4105E39	Enoyl-CoA hydratase
Tbis_2855	ENOG4105E2K	Glycosyl transferase (Group 1
Tbis_2857	ENOG4108IUN	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
Tbis_2858	ENOG4105EP6	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity)
Tbis_2860	ENOG41070F3	Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity)
Tbis_2861	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
Tbis_2865	ENOG4105MXW	flavin reductase domain protein, FMN-binding
Tbis_2867	ENOG4105CEY	Amp-dependent synthetase and ligase
Tbis_2871	ENOG4108SGK	Tetr family transcriptional regulator
Tbis_2872	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
Tbis_2873	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
Tbis_2874	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
Tbis_2882	ENOG4105DFW	ABC transporter
Tbis_2883	ENOG4105CNN	ABC, transporter
Tbis_2884	ENOG4105C2J	ABC transporter
Tbis_2890	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
Tbis_2893	ENOG4105CB2	alcohol dehydrogenase
Tbis_2903	ENOG4108VEQ	Superoxide dismutase
Tbis_2904	ENOG4108ZBE	Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity)
Tbis_2911	ENOG4105FDP	GntR family transcriptional regulator
Tbis_2915	ENOG4107TPY	serine threonine protein kinase
Tbis_2917	ENOG4106063	Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit
Tbis_2919	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
Tbis_2923	ENOG4105EMN	RNA polymerase sigma factor
Tbis_2926	ENOG4108RAV	Conserved protein
Tbis_2927	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
Tbis_2929	ENOG4107TK4	histidinol-phosphate phosphatase
Tbis_2932	ENOG4105KJF	protein tyrosine phosphatase
Tbis_2935	ENOG4105E2Z	phosphate ABC transporter (Permease
Tbis_2936	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
Tbis_2938	ENOG4105DEF	Extracellular solute-binding protein, family 5
Tbis_2946	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Tbis_2947	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
Tbis_2948	ENOG4105DEF	Extracellular solute-binding protein, family 5
Tbis_2951	ENOG4105JAB	phenazine biosynthesis protein, phzf family
Tbis_2952	ENOG4105DJZ	UPF0182 protein
Tbis_2953	ENOG41063PX	domain protein
Tbis_2963	ENOG4105WBQ	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity)
Tbis_2964	ENOG4105C29	acyl-CoA thioesterase
Tbis_2972	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
Tbis_2974	ENOG4105C4R	Atp-dependent dna helicase
Tbis_2975	ENOG4107SJB	teichoic acid biosynthesis
Tbis_2978	ENOG41090GG	peptidase S8 and S53, subtilisin, kexin, sedolisin
Tbis_2990	ENOG4105FDF	Could be involved in DNA repair (By similarity)
Tbis_2991	ENOG4105DQE	DNA ligase
Tbis_2996	ENOG4105C1J	atp-dependent rna helicase
Tbis_3003	ENOG4107FCW	Abortive infection protein
Tbis_3004	ENOG4105CI0	Citrate lyase
Tbis_3005	ENOG4107ZYJ	bioY protein
Tbis_3009	ENOG4105CJW	magnesium transporter
Tbis_3012	ENOG410630M	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
Tbis_3014	ENOG4105DU6	RNA polymerase
Tbis_3016	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
Tbis_3018	ENOG4105CGU	Enoyl-CoA hydratase
Tbis_3019	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
Tbis_3022	ENOG4107R4C	succinyl-diaminopimelate desuccinylase
Tbis_3023	ENOG4108URH	decarboxylase
Tbis_3024	ENOG4108URH	decarboxylase
Tbis_3028	ENOG4108Z4U	Ferredoxin
Tbis_3030	ENOG4107R6G	Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity)
Tbis_3032	ENOG41088T4	Helicase IV
Tbis_3034	ENOG4105C8N	cysteinyl-tRNA synthetase
Tbis_3036	ENOG4108KZ5	Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity)
Tbis_3050	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
Tbis_3053	ENOG4105M6F	mutator MutT protein
Tbis_3062	ENOG4105C3G	gtp-binding protein
Tbis_3065	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
Tbis_3067	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
Tbis_3068	ENOG4105CAQ	asparagine synthetase
Tbis_3069	ENOG4105YX8	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
Tbis_3075	ENOG4108HRG	Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity)
Tbis_3076	ENOG4105DH8	myo-inositol catabolism
Tbis_3078	ENOG4105D7K	pfkb domain protein
Tbis_3079	ENOG4105CJK	Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity)
Tbis_3080	ENOG4105CK5	oxidoreductase
Tbis_3082	ENOG4107GFK	fumarate
Tbis_3083	ENOG4107TPY	serine threonine protein kinase
Tbis_3084	ENOG4105D9P	serine threonine protein kinase
Tbis_3085	ENOG4105C9Q	fumarate hydratase class II
Tbis_3089	ENOG4108KXV	response regulator
Tbis_3090	ENOG41065SU	Two-component system sensor kinase
Tbis_3092	ENOG4108IAB	Phoh family
Tbis_3093	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
Tbis_3094	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
Tbis_3096	ENOG4107YD5	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
Tbis_3098	ENOG4105T1M	mycothiol conjugate amidase mca
Tbis_3106	ENOG4105BZ4	penicillin-binding protein
Tbis_3108	ENOG4105E6K	4-Hydroxyphenylpyruvate dioxygenase
Tbis_3111	ENOG4105C31	Tryptophanyl-tRNA synthetase
Tbis_3112	ENOG4105C7B	Threonine dehydratase
Tbis_3114	ENOG4105EET	magnesium chelatase
Tbis_3115	ENOG4107KWJ	von Willebrand factor, type A
Tbis_3121	ENOG4105CHU	acetyl-coa acetyltransferase
Tbis_3125	ENOG4106F60	Histidine kinase
Tbis_3126	ENOG4105DXI	Major Facilitator superfamily
Tbis_3132	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
Tbis_3137	ENOG4107T1U	Catalyzes the synthesis of activated sulfate (By similarity)
Tbis_3142	ENOG4105D9P	serine threonine protein kinase
Tbis_3149	ENOG4105C11	sulfate adenylyltransferase), subunit 2
Tbis_3150	ENOG4108RM3	Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I- 1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F- 6-P)) and AMP in vitro, but this might has no significance in vivo
Tbis_3151	ENOG4105D3Q	Sugar transferase
Tbis_3152	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
Tbis_3153	ENOG4107XT7	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
Tbis_3154	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
Tbis_3155	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
Tbis_3157	ENOG41067SE	Tetr family transcriptional regulator
Tbis_3158	ENOG4107R6G	Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity)
Tbis_3159	ENOG4108T3F	Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes
Tbis_3161	ENOG4105C5H	ABC transporter
Tbis_3165	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
Tbis_3166	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
Tbis_3167	ENOG4105F8V	Hydrolase, tatD family
Tbis_3169	ENOG4107R16	Multicopper oxidase
Tbis_3171	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
Tbis_3172	ENOG4105CKK	Glycosyl transferase, family 2
Tbis_3184	ENOG4105D9U	N-acetyltransferase
Tbis_3185	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
Tbis_3186	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
Tbis_3188	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
Tbis_3189	ENOG41080UU	5-formyltetrahydrofolate cyclo-ligase
Tbis_3190	ENOG4105C3N	Participates in control of cell volume in low-osmolarity conditions (By similarity)
Tbis_3192	ENOG4107USC	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity)
Tbis_3199	ENOG4108KPJ	rna polymerase sigma factor
Tbis_3200	ENOG4108X07	Tetr family transcriptional regulator
Tbis_3201	ENOG4105CIG	ABC transporter
Tbis_3202	ENOG4105DIM	ABC transporter
Tbis_3203	ENOG4105C1G	acyl-Coa dehydrogenase
Tbis_3204	ENOG4105CSH	Transporter
Tbis_3206	ENOG4105C1G	acyl-Coa dehydrogenase
Tbis_3207	ENOG4108VUG	Enoyl-CoA hydratase
Tbis_3208	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
Tbis_3210	ENOG410832A	alpha/beta hydrolase fold
Tbis_3211	ENOG4105CEY	Amp-dependent synthetase and ligase
Tbis_3216	ENOG4105CDV	Ompa motb domain protein
Tbis_3217	ENOG4105MDH	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity)
Tbis_3218	ENOG4108JEB	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
Tbis_3219	ENOG4107RSS	Hydrogenase accessory protein HypB
Tbis_3220	ENOG4105WMM	Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity)
Tbis_3224	ENOG4105DPX	Hydrogenase, large subunit
Tbis_3225	ENOG4108USZ	hydrogenase
Tbis_3236	ENOG4105CQS	hydrogenase expression formation protein HypD
Tbis_3239	ENOG4105E2A	Dehydrogenase
Tbis_3243	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
Tbis_3244	ENOG4107QR9	Iron-sulfur cluster binding protein
Tbis_3245	ENOG41080R8	Conserved Protein
Tbis_3249	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
Tbis_3261	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
Tbis_3262	ENOG4108VK3	Cupin 2 Conserved Barrel Domain Protein
Tbis_3265	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
Tbis_3267	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
Tbis_3269	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Tbis_3270	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Tbis_3275	ENOG4105BZU	Histidine kinase
Tbis_3276	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
Tbis_3277	ENOG4105D5U	fad dependent oxidoreductase
Tbis_3284	ENOG41061H0	Monooxygenase
Tbis_3286	ENOG4105CPC	Aldo Keto reductase
Tbis_3290	ENOG4105C7N	Xanthine uracil vitamin C permease
Tbis_3294	ENOG4105VEQ	Cold shock protein
Tbis_3296	ENOG4105CFI	type iii restriction protein res subunit
Tbis_3297	ENOG4105EEM	helicase
Tbis_3298	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
Tbis_3306	ENOG4107V4F	S-adenosyl-l-methionine hydroxide adenosyltransferase
Tbis_3307	ENOG4108JQ7	(ABC) transporter
Tbis_3309	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Tbis_3311	ENOG4107QSI	ABC, transporter
Tbis_3313	ENOG4105EY8	ABC transporter
Tbis_3314	ENOG4108V1U	phospholipid-binding protein
Tbis_3318	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
Tbis_3319	ENOG4105C75	arginyL-tRNA synthetase
Tbis_3321	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
Tbis_3324	ENOG4108J2R	molybdopterin oxidoreductase
Tbis_3327	ENOG4105CSU	acyl-Coa dehydrogenase
Tbis_3330	ENOG4107RN0	branched-chain alpha-keto acid dehydrogenase subunit E2
Tbis_3331	ENOG4105CPP	Dehydrogenase, E1 component
Tbis_3334	ENOG4105CSH	Transporter
Tbis_3336	ENOG410839H	phosphoribosylformylglycinamidine synthase
Tbis_3338	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
Tbis_3339	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
Tbis_3344	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
Tbis_3347	ENOG4108TAC	
Tbis_3349	ENOG4108MHR	Repressor involved in choline regulation of the bet genes (By similarity)
Tbis_3350	ENOG4105ETE	Transcriptional regulator (LacI family
Tbis_3352	ENOG4108RU2	n-acetylmuramoyl-l-alanine amidase
Tbis_3353	ENOG4105E2D	ec 3.2.1.52
Tbis_3359	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
Tbis_3367	ENOG4105C1G	acyl-Coa dehydrogenase
Tbis_3369	ENOG410635A	Membrane
Tbis_3370	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
Tbis_3372	ENOG41062D9	Histidine kinase
Tbis_3373	ENOG4105K78	MarR family Transcriptional regulator
Tbis_3379	ENOG4105VBF	alkaline shock protein
Tbis_3382	ENOG4105MRC	Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth
Tbis_3386	ENOG4105W2E	Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity)
Tbis_3388	ENOG4107ETC	gas vesicle protein
Tbis_3389	ENOG4108XNA	Gas vesicle
Tbis_3390	ENOG4105WH1	Two component transcriptional regulator luxr family
Tbis_3391	ENOG4105BZU	Histidine kinase
Tbis_3394	ENOG4105MC2	DSBA oxidoreductase
Tbis_3397	ENOG4105FDP	GntR family transcriptional regulator
Tbis_3399	ENOG4108Z0R	Transferase
Tbis_3404	ENOG4105VPX	protein, conserved in bacteria
Tbis_3405	ENOG4108I69	Glycosyl transferases group 1
Tbis_3407	ENOG4105DF6	Fe-S oxidoreductase
Tbis_3408	ENOG4108MHR	Repressor involved in choline regulation of the bet genes (By similarity)
Tbis_3409	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
Tbis_3410	ENOG4105EY0	Xylose isomerase domain protein TIM barrel
Tbis_3412	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
Tbis_3414	ENOG4105CEN	a g-specific adenine glycosylase
Tbis_3416	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
Tbis_3417	ENOG4105RFA	Lsr2-like protein
Tbis_3422	ENOG4105CRK	lysyL-tRNA synthetase
Tbis_3423	ENOG4105CGM	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
Tbis_3424	ENOG4108IYU	L-aspartate oxidase
Tbis_3425	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
Tbis_3426	ENOG4107QQT	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
Tbis_3430	ENOG4105DA5	(ABC) transporter
Tbis_3432	ENOG4105I6B	RNA polymerase
Tbis_3438	ENOG4106A3M	Cytochrome p-450
Tbis_3439	ENOG4105C9B	Cysteine desulfurase
Tbis_3440	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Tbis_3442	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Tbis_3445	ENOG4105EEI	dihydropteroate synthase
Tbis_3446	ENOG4105EUJ	GTP cyclohydrolase i
Tbis_3447	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
Tbis_3449	ENOG4107RD1	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
Tbis_3452	ENOG4105F0N	pyrophosphate phospho-hydrolase
Tbis_3453	ENOG4105ZXU	NLP P60 protein
Tbis_3455	ENOG4105EG6	Saccharopine dehydrogenase
Tbis_3459	ENOG4105DY8	decarboxylase
Tbis_3460	ENOG4105F1Y	L-lysine 6-monooxygenase (NADPH)
Tbis_3462	ENOG4105DUU	IucA IucC family protein
Tbis_3465	ENOG4105MA4	psp1 domain protein
Tbis_3466	ENOG4105FA2	dna polymerase iii
Tbis_3467	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
Tbis_3468	ENOG4107RN3	metallophosphoesterase
Tbis_3469	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
Tbis_3473	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
Tbis_3480	ENOG4105CJ1	ABC, transporter
Tbis_3481	ENOG4105F0K	SARP family transcriptional regulator
Tbis_3494	ENOG4106PVI	ATP-dependent carboxylate-amine ligase (By similarity)
Tbis_3496	ENOG4105E0A	ABC, transporter
Tbis_3497	ENOG4105DQ5	transport system permease protein
Tbis_3503	ENOG4105D9P	serine threonine protein kinase
Tbis_3507	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
Tbis_3511	ENOG4105EIP	mannose-6-phosphate isomerase
Tbis_3513	ENOG4105ETE	Transcriptional regulator (LacI family
Tbis_3516	ENOG4105D9P	serine threonine protein kinase
Tbis_3517	ENOG4105BZ1	(ABC) transporter
Tbis_3521	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
Tbis_3522	ENOG4108IG5	Transcriptional regulator
Tbis_3526	ENOG41079Y2	Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone
Tbis_3528	ENOG4105CFH	Aspartokinase
Tbis_3530	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
Tbis_3531	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
Tbis_3536	ENOG4108Z6B	deaminase
Tbis_3539	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
Tbis_3543	ENOG41073TP	transcriptional regulator
Tbis_3544	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
Tbis_3545	ENOG4105WH1	Two component transcriptional regulator luxr family
Tbis_3547	ENOG4108M15	ABC transporter
Tbis_3550	ENOG4107ZXU	DSBA oxidoreductase
Tbis_3552	ENOG4105KVH	Transcriptional regulator
Tbis_3553	ENOG4105CDU	Replicative dna helicase
Tbis_3554	ENOG4107QI1	Mate efflux family protein
Tbis_3556	ENOG4105EAD	ABC transporter
Tbis_3557	ENOG4105EAB	amino acid AbC transporter
Tbis_3558	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
Tbis_3559	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
Tbis_3561	ENOG410829C	Binds together with S18 to 16S ribosomal RNA (By similarity)
Tbis_3566	ENOG4105BZ4	penicillin-binding protein
Tbis_3571	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
Tbis_3575	ENOG4105D9P	serine threonine protein kinase
Tbis_3578	ENOG4105C3M	thioredoxin reductase
Tbis_3579	ENOG4105K63	Thioredoxin
Tbis_3581	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
Tbis_3582	ENOG4105CPF	Cell wall formation (By similarity)
Tbis_3589	ENOG4107QJE	Chromosome Partitioning Protein
Tbis_3590	ENOG4107XUG	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
Tbis_3593	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
Tbis_3594	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
Tbis_3596	ENOG41084CH	50S ribosomal protein l34