locus-tag	class	description
Tbis_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Tbis_0002	COG0592	DNA-directed DNA polymerase activity
Tbis_0003	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Tbis_0004	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Tbis_0005	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
Tbis_0006	COG0187	DNA topoisomerase II activity
Tbis_0007	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Tbis_0009	COG1742	UPF0060 membrane protein
Tbis_0014	COG2608	mercury ion transmembrane transporter activity
Tbis_0015	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Tbis_0018	COG4604	ABC transporter, ATP-binding protein
Tbis_0019	COG4605	iron ion homeostasis
Tbis_0020	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Tbis_0021	COG4607	ABC-type enterochelin transport system periplasmic component
Tbis_0027	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Tbis_0034	COG1215	transferase activity, transferring glycosyl groups
Tbis_0040	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Tbis_0042	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Tbis_0043	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Tbis_0046	COG1316	TRANSCRIPTIONal
Tbis_0050	COG1716	ATPase activity
Tbis_0053	COG0768	penicillin binding
Tbis_0054	COG0515	serine threonine protein kinase
Tbis_0055	COG0515	serine threonine protein kinase
Tbis_0064	COG0840	transmembrane signaling receptor activity
Tbis_0068	COG1175	transmembrane transport
Tbis_0069	COG1653	transport
Tbis_0072	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Tbis_0073	COG1278	Cold shock
Tbis_0074	COG0561	phosphatase activity
Tbis_0091	COG2186	Transcriptional regulator
Tbis_0095	COG1309	transcriptional regulator
Tbis_0097	COG0515	serine threonine protein kinase
Tbis_0098	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Tbis_0105	COG3391	amine dehydrogenase activity
Tbis_0119	COG1595	DNA-templated transcription, initiation
Tbis_0121	COG1846	Transcriptional regulator
Tbis_0128	COG2814	Major facilitator Superfamily
Tbis_0130	COG3226	Transcriptional regulator
Tbis_0132	COG1322	Protein conserved in bacteria
Tbis_0133	COG1525	nuclease
Tbis_0134	COG1115	amino acid carrier protein
Tbis_0137	COG3708	Transcriptional regulator
Tbis_0137	COG2207	Transcriptional regulator
Tbis_0140	COG0543	2 iron, 2 sulfur cluster binding
Tbis_0140	COG0633	Ferredoxin
Tbis_0141	COG1151	hydroxylamine reductase activity
Tbis_0144	COG1522	sequence-specific DNA binding
Tbis_0147	COG0346	lactoylglutathione lyase activity
Tbis_0149	COG1940	carbohydrate kinase activity
Tbis_0151	COG1070	Carbohydrate kinase
Tbis_0155	COG2018	Roadblock/LC7 domain
Tbis_0166	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Tbis_0168	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Tbis_0169	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Tbis_0170	COG0151	Belongs to the GarS family
Tbis_0172	COG1309	transcriptional regulator
Tbis_0175	COG0584	glycerophosphoryl diester phosphodiesterase
Tbis_0176	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Tbis_0181	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Tbis_0183	COG1432	Conserved Protein
Tbis_0185	COG0784	Response regulator, receiver
Tbis_0185	COG5002	protein histidine kinase activity
Tbis_0186	COG2770	Histidine kinase
Tbis_0186	COG2208	phosphoserine phosphatase activity
Tbis_0187	COG2226	methyltransferase
Tbis_0193	COG1408	metallophosphoesterase
Tbis_0195	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Tbis_0197	COG0003	Pfam Anion-transporting ATPase
Tbis_0203	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tbis_0205	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Tbis_0207	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tbis_0209	COG0596	Alpha beta hydrolase
Tbis_0211	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tbis_0220	COG1205	dead DEAH box helicase
Tbis_0220	COG1111	helicase
Tbis_0221	COG1366	Belongs to the anti-sigma-factor antagonist family
Tbis_0223	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Tbis_0225	COG3830	Belongs to the UPF0237 family
Tbis_0225	COG0560	Phosphoserine phosphatase
Tbis_0227	COG4585	Histidine kinase
Tbis_0228	COG2197	response regulator
Tbis_0229	COG1119	ATPase activity
Tbis_0236	COG0753	catalase activity
Tbis_0239	COG1309	transcriptional regulator
Tbis_0243	COG0542	response to heat
Tbis_0244	COG0789	Transcriptional regulator
Tbis_0245	COG0484	heat shock protein binding
Tbis_0246	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Tbis_0247	COG0443	Heat shock 70 kDa protein
Tbis_0249	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Tbis_0250	COG0123	including yeast histone deacetylase and acetoin utilization protein
Tbis_0255	COG0560	Phosphoserine phosphatase
Tbis_0260	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
Tbis_0261	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Tbis_0262	COG0181	hydroxymethylbilane synthase activity
Tbis_0264	COG0113	porphobilinogen synthase activity
Tbis_0266	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Tbis_0268	COG0406	alpha-ribazole phosphatase activity
Tbis_0269	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Tbis_0270	COG0785	Cytochrome C biogenesis protein
Tbis_0272	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Tbis_0278	COG2226	methyltransferase
Tbis_0282	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tbis_0283	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tbis_0284	COG0649	NAD binding
Tbis_0287	COG1034	ATP synthesis coupled electron transport
Tbis_0288	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Tbis_0289	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tbis_0291	COG0713	ATP synthesis coupled electron transport
Tbis_0294	COG1007	ATP synthesis coupled electron transport
Tbis_0298	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Tbis_0305	COG0697	spore germination
Tbis_0307	COG0444	Belongs to the ABC transporter superfamily
Tbis_0308	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Tbis_0310	COG0747	negative chemotaxis
Tbis_0313	COG1013	pyruvate-flavodoxin oxidoreductase activity
Tbis_0314	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Tbis_0314	COG0674	pyruvate-flavodoxin oxidoreductase activity
Tbis_0315	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tbis_0316	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tbis_0317	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tbis_0318	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Tbis_0320	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tbis_0322	COG0713	ATP synthesis coupled electron transport
Tbis_0325	COG1007	ATP synthesis coupled electron transport
Tbis_0326	COG0501	Belongs to the peptidase M48B family
Tbis_0328	COG0765	amino acid transport
Tbis_0329	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Tbis_0332	COG1666	GTP binding
Tbis_0341	COG0494	nUDIX hydrolase
Tbis_0343	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Tbis_0344	COG1247	-acetyltransferase
Tbis_0345	COG0640	Transcriptional regulator
Tbis_0353	COG1366	Belongs to the anti-sigma-factor antagonist family
Tbis_0356	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Tbis_0357	COG2030	dehydratase
Tbis_0359	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Tbis_0360	COG2119	membrane
Tbis_0361	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
Tbis_0361	COG1672	PFAM Archaeal ATPase
Tbis_0363	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Tbis_0364	COG1012	belongs to the aldehyde dehydrogenase family
Tbis_0365	COG1012	belongs to the aldehyde dehydrogenase family
Tbis_0368	COG0321	lipoyl(octanoyl) transferase activity
Tbis_0370	COG0803	Belongs to the bacterial solute-binding protein 9 family
Tbis_0371	COG1121	(ABC) transporter
Tbis_0373	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Tbis_0380	COG0640	Transcriptional regulator
Tbis_0381	COG1902	pentaerythritol trinitrate reductase activity
Tbis_0382	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Tbis_0386	COG3903	Transcriptional regulator
Tbis_0386	COG3629	intracellular signal transduction
Tbis_0388	COG3509	depolymerase
Tbis_0389	COG2856	Zn peptidase
Tbis_0394	COG2239	Acts as a magnesium transporter
Tbis_0395	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Tbis_0396	COG1993	acr, cog1993
Tbis_0397	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Tbis_0403	COG1309	transcriptional regulator
Tbis_0404	COG0683	leucine binding
Tbis_0405	COG0559	Belongs to the binding-protein-dependent transport system permease family
Tbis_0407	COG0411	ABC transporter
Tbis_0408	COG0410	ABC transporter
Tbis_0409	COG4326	sporulation control protein
Tbis_0410	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
Tbis_0412	COG1309	transcriptional regulator
Tbis_0418	COG0411	ABC transporter
Tbis_0419	COG0410	ABC transporter
Tbis_0420	COG0559	Belongs to the binding-protein-dependent transport system permease family
Tbis_0433	COG0183	Belongs to the thiolase family
Tbis_0435	COG0640	Transcriptional regulator
Tbis_0436	COG0402	S-adenosylhomocysteine deaminase activity
Tbis_0442	COG2076	Multidrug Resistance protein
Tbis_0448	COG0717	Belongs to the dCTP deaminase family
Tbis_0451	COG0456	acetyltransferase
Tbis_0452	COG0737	Belongs to the 5'-nucleotidase family
Tbis_0453	COG0745	RESPONSE REGULATOR receiver
Tbis_0460	COG2897	thiosulfate sulfurtransferase activity
Tbis_0468	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Tbis_0469	COG3442	glutamine amidotransferase
Tbis_0471	COG4044	May play a role in the intracellular transport of hydrophobic ligands
Tbis_0473	COG0735	belongs to the Fur family
Tbis_0474	COG1366	Belongs to the anti-sigma-factor antagonist family
Tbis_0475	COG1366	Belongs to the anti-sigma-factor antagonist family
Tbis_0476	COG2172	sigma factor antagonist activity
Tbis_0478	COG2205	protein histidine kinase activity
Tbis_0478	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Tbis_0480	COG0354	folic acid binding
Tbis_0481	COG1490	D-aminoacyl-tRNA deacylase activity
Tbis_0483	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
Tbis_0485	COG0598	Magnesium transport protein CorA
Tbis_0489	COG0501	Belongs to the peptidase M48B family
Tbis_0494	COG0438	transferase activity, transferring glycosyl groups
Tbis_0496	COG0588	phosphoglycerate mutase activity
Tbis_0498	COG5002	protein histidine kinase activity
Tbis_0501	COG1329	Transcriptional regulator
Tbis_0502	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Tbis_0506	COG0215	cysteine-tRNA ligase activity
Tbis_0509	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Tbis_0510	COG1733	regulation of RNA biosynthetic process
Tbis_0512	COG0310	cobalt ion transport
Tbis_0515	COG1122	ATPase activity
Tbis_0517	COG1024	Enoyl-CoA hydratase
Tbis_0519	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Tbis_0521	COG0259	pyridoxamine-phosphate oxidase activity
Tbis_0522	COG1573	uracil-dna glycosylase
Tbis_0526	COG1960	acyl-CoA dehydrogenase activity
Tbis_0533	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Tbis_0534	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Tbis_0535	COG0436	Aminotransferase
Tbis_0538	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Tbis_0539	COG0081	regulation of translation
Tbis_0542	COG0222	ribosome binding
Tbis_0543	COG0085	RNA polymerase activity
Tbis_0544	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Tbis_0545	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Tbis_0546	COG2124	cytochrome p450
Tbis_0547	COG2124	cytochrome p450
Tbis_0548	COG1309	transcriptional regulator
Tbis_0557	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Tbis_0558	COG0049	tRNA binding
Tbis_0559	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Tbis_0561	COG0051	transcription antitermination factor activity, RNA binding
Tbis_0562	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Tbis_0563	COG0088	Forms part of the polypeptide exit tunnel
Tbis_0564	COG0089	rRNA binding
Tbis_0565	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Tbis_0566	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Tbis_0567	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Tbis_0568	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Tbis_0569	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Tbis_0570	COG0255	Belongs to the universal ribosomal protein uL29 family
Tbis_0571	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Tbis_0572	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Tbis_0573	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Tbis_0574	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Tbis_0575	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Tbis_0576	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Tbis_0577	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Tbis_0578	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Tbis_0579	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Tbis_0580	COG1841	ribosomal large subunit assembly
Tbis_0581	COG0200	Binds to the 23S rRNA
Tbis_0583	COG0563	adenylate kinase activity
Tbis_0588	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Tbis_0589	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Tbis_0590	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Tbis_0591	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Tbis_0592	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Tbis_0593	COG0202	RNA polymerase activity
Tbis_0594	COG0203	ribosomal protein L17
Tbis_0595	COG0101	tRNA pseudouridine synthase activity
Tbis_0599	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Tbis_0600	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Tbis_0601	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Tbis_0603	COG1131	(ABC) transporter
Tbis_0606	COG1072	(Pantothenic acid kinase))
Tbis_0607	COG0736	holo-[acyl-carrier-protein] synthase activity
Tbis_0609	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Tbis_0611	COG0802	atpase or kinase
Tbis_0615	COG0456	acetyltransferase
Tbis_0615	COG1214	PFAM Peptidase M22, glycoprotease
Tbis_0616	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Tbis_0619	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Tbis_0620	COG0459	protein refolding
Tbis_0621	COG1595	DNA-templated transcription, initiation
Tbis_0624	COG0516	GMP reductase activity
Tbis_0625	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Tbis_0626	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Tbis_0627	COG1012	belongs to the aldehyde dehydrogenase family
Tbis_0629	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Tbis_0629	COG0519	Catalyzes the synthesis of GMP from XMP
Tbis_0631	COG0789	Transcriptional regulator
Tbis_0633	COG0726	polysaccharide deacetylase
Tbis_0635	COG0463	Glycosyl transferase, family 2
Tbis_0636	COG1216	Glycosyl transferase, family 2
Tbis_0637	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
Tbis_0639	COG0438	transferase activity, transferring glycosyl groups
Tbis_0641	COG0457	Tetratricopeptide repeat
Tbis_0649	COG2197	response regulator
Tbis_0651	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Tbis_0654	COG0045	succinate-CoA ligase (ADP-forming) activity
Tbis_0660	COG0138	bifunctional purine biosynthesis protein purh
Tbis_0661	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Tbis_0663	COG0372	Belongs to the citrate synthase family
Tbis_0669	COG1253	flavin adenine dinucleotide binding
Tbis_0670	COG0180	Tryptophanyl-tRNA synthetase
Tbis_0674	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Tbis_0675	COG1473	amidohydrolase
Tbis_0675	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Tbis_0684	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Tbis_0686	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Tbis_0691	COG4770	biotin carboxylase activity
Tbis_0693	COG1674	ftsk spoiiie
Tbis_0696	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Tbis_0698	COG1432	Conserved Protein
Tbis_0700	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Tbis_0701	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Tbis_0704	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
Tbis_0706	COG2193	ferroxidase activity
Tbis_0707	COG0745	RESPONSE REGULATOR receiver
Tbis_0708	COG5002	protein histidine kinase activity
Tbis_0713	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Tbis_0716	COG1285	pathogenesis
Tbis_0717	COG1316	TRANSCRIPTIONal
Tbis_0719	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Tbis_0722	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Tbis_0723	COG0371	Dehydrogenase
Tbis_0727	COG3594	Acyltransferase
Tbis_0728	COG1316	TRANSCRIPTIONal
Tbis_0736	COG1271	oxidase subunit
Tbis_0737	COG1294	oxidase, subunit
Tbis_0738	COG4988	ABC transporter
Tbis_0739	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
Tbis_0740	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Tbis_0742	COG2226	methyltransferase
Tbis_0746	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Tbis_0748	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
Tbis_0748	COG0778	Nitroreductase
Tbis_0757	COG2835	tetraacyldisaccharide 4'-kinase activity
Tbis_0763	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Tbis_0764	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Tbis_0770	COG0745	RESPONSE REGULATOR receiver
Tbis_0771	COG5002	protein histidine kinase activity
Tbis_0772	COG0823	Involved in the tonB-independent uptake of proteins
Tbis_0774	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Tbis_0775	COG2197	response regulator
Tbis_0777	COG0653	protein targeting
Tbis_0780	COG3509	depolymerase
Tbis_0781	COG2188	Transcriptional regulator
Tbis_0782	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Tbis_0783	COG1472	Belongs to the glycosyl hydrolase 3 family
Tbis_0784	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Tbis_0787	COG0546	phosphoglycolate phosphatase activity
Tbis_0788	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tbis_0789	COG2902	Dehydrogenase
Tbis_0791	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Tbis_0793	COG2884	Cell division ATP-binding protein ftsE
Tbis_0794	COG2177	Part of the ABC transporter FtsEX involved in
Tbis_0795	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Tbis_0798	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tbis_0801	COG1960	acyl-CoA dehydrogenase activity
Tbis_0805	COG4981	capsule polysaccharide biosynthetic process
Tbis_0807	COG0500	methyltransferase
Tbis_0812	COG0277	FAD linked oxidase domain protein
Tbis_0813	COG0300	oxidoreductase activity
Tbis_0820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Tbis_0821	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Tbis_0822	COG0686	Belongs to the AlaDH PNT family
Tbis_0824	COG0789	Transcriptional regulator
Tbis_0825	COG0405	Gamma-glutamyltransferase
Tbis_0829	COG2814	Major facilitator Superfamily
Tbis_0833	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Tbis_0842	COG1653	transport
Tbis_0843	COG2273	Hydrolase Family 16
Tbis_0845	COG0745	RESPONSE REGULATOR receiver
Tbis_0845	COG3706	GGDEF domain
Tbis_0848	COG2208	phosphoserine phosphatase activity
Tbis_0848	COG2770	Histidine kinase
Tbis_0850	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Tbis_0856	COG2271	Major facilitator Superfamily
Tbis_0860	COG2815	serine threonine protein kinase
Tbis_0860	COG0515	serine threonine protein kinase
Tbis_0867	COG0395	ABC-type sugar transport system, permease component
Tbis_0868	COG1175	transmembrane transport
Tbis_0869	COG1653	transport
Tbis_0870	COG1653	transport
Tbis_0872	COG1136	(ABC) transporter
Tbis_0874	COG0366	Alpha amylase catalytic
Tbis_0878	COG0019	diaminopimelate decarboxylase activity
Tbis_0879	COG0460	homoserine dehydrogenase
Tbis_0882	COG1215	transferase activity, transferring glycosyl groups
Tbis_0884	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Tbis_0885	COG0083	homoserine kinase activity
Tbis_0887	COG0254	rRNA binding
Tbis_0888	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Tbis_0889	COG2890	protein-(glutamine-N5) methyltransferase activity
Tbis_0895	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Tbis_0896	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Tbis_0897	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Tbis_0898	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Tbis_0899	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Tbis_0900	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Tbis_0901	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Tbis_0904	COG4152	abc transporter atp-binding protein
Tbis_0905	COG1668	transmembrane transport
Tbis_0906	COG4585	Histidine kinase
Tbis_0907	COG2197	response regulator
Tbis_0911	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
Tbis_0914	COG0596	Alpha beta hydrolase
Tbis_0917	COG0183	Belongs to the thiolase family
Tbis_0924	COG1678	Uncharacterized ACR, COG1678
Tbis_0926	COG0477	Major facilitator Superfamily
Tbis_0932	COG1335	isochorismatase
Tbis_0934	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Tbis_0940	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Tbis_0941	COG1234	tRNA 3'-trailer cleavage
Tbis_0942	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Tbis_0943	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Tbis_0947	COG0477	Major facilitator Superfamily
Tbis_0949	COG1136	(ABC) transporter
Tbis_0949	COG0577	efflux transmembrane transporter activity
Tbis_0950	COG0577	efflux transmembrane transporter activity
Tbis_0950	COG1136	(ABC) transporter
Tbis_0951	COG2197	response regulator
Tbis_0952	COG4585	Histidine kinase
Tbis_0960	COG0509	glycine decarboxylation via glycine cleavage system
Tbis_0961	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Tbis_0964	COG4221	oxidoreductase activity
Tbis_0966	COG1228	amidohydrolase
Tbis_0971	COG2018	Roadblock/LC7 domain
Tbis_0974	COG5002	protein histidine kinase activity
Tbis_0975	COG2018	Roadblock/LC7 domain
Tbis_0979	COG0228	four-way junction DNA binding
Tbis_0980	COG1837	Belongs to the UPF0109 family
Tbis_0981	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Tbis_0982	COG0336	Belongs to the RNA methyltransferase TrmD family
Tbis_0983	COG0335	large ribosomal subunit rRNA binding
Tbis_0984	COG0681	Belongs to the peptidase S26 family
Tbis_0986	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Tbis_0991	COG0606	chelatase, subunit chli
Tbis_0992	COG0792	nuclease activity
Tbis_0993	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tbis_0994	COG0052	Belongs to the universal ribosomal protein uS2 family
Tbis_0995	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Tbis_0996	COG0528	UMP kinase activity
Tbis_0997	COG0233	cytoplasmic translational termination
Tbis_0998	COG0575	Belongs to the CDS family
Tbis_1000	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Tbis_1003	COG3835	regulator
Tbis_1007	COG1522	sequence-specific DNA binding
Tbis_1008	COG1012	belongs to the aldehyde dehydrogenase family
Tbis_1009	COG3842	ATPase activity
Tbis_1011	COG1176	ABC-type spermidine putrescine transport system, permease component I
Tbis_1012	COG1177	transmembrane transport
Tbis_1013	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Tbis_1014	COG0640	Transcriptional regulator
Tbis_1017	COG1028	Short-chain dehydrogenase reductase Sdr
Tbis_1022	COG3469	chitinase activity
Tbis_1025	COG0628	permease
Tbis_1032	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Tbis_1037	COG1012	belongs to the aldehyde dehydrogenase family
Tbis_1041	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Tbis_1044	COG1309	transcriptional regulator
Tbis_1045	COG2409	Drug exporters of the RND superfamily
Tbis_1055	COG0442	prolyl-tRNA aminoacylation
Tbis_1058	COG0779	Required for maturation of 30S ribosomal subunits
Tbis_1061	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Tbis_1063	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Tbis_1064	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Tbis_1065	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Tbis_1067	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Tbis_1068	COG1185	polyribonucleotide nucleotidyltransferase activity
Tbis_1069	COG0612	Peptidase, M16
Tbis_1070	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Tbis_1074	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Tbis_1076	COG2188	Transcriptional regulator
Tbis_1077	COG2003	Belongs to the UPF0758 family
Tbis_1080	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Tbis_1081	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Tbis_1083	COG4948	Mandelate Racemase Muconate Lactonizing
Tbis_1084	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Tbis_1085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Tbis_1087	COG3866	Pectate lyase
Tbis_1089	COG0395	ABC-type sugar transport system, permease component
Tbis_1091	COG4948	Mandelate Racemase Muconate Lactonizing
Tbis_1092	COG1414	Transcriptional regulator
Tbis_1093	COG1674	ftsk spoiiie
Tbis_1095	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tbis_1097	COG1546	Belongs to the CinA family
Tbis_1097	COG1058	Belongs to the CinA family
Tbis_1098	COG1396	sequence-specific DNA binding
Tbis_1099	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Tbis_1101	COG1940	carbohydrate kinase activity
Tbis_1102	COG1472	Belongs to the glycosyl hydrolase 3 family
Tbis_1104	COG1175	transmembrane transport
Tbis_1113	COG1201	RNA secondary structure unwinding
Tbis_1115	COG4152	abc transporter atp-binding protein
Tbis_1116	COG1668	transmembrane transport
Tbis_1118	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Tbis_1119	COG2137	regulation of response to DNA damage stimulus
Tbis_1120	COG1418	mRNA catabolic process
Tbis_1122	COG0765	amino acid transport
Tbis_1123	COG0765	amino acid transport
Tbis_1124	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Tbis_1125	COG1126	abc transporter atp-binding protein
Tbis_1126	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tbis_1128	COG1234	tRNA 3'-trailer cleavage
Tbis_1130	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Tbis_1131	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Tbis_1136	COG0247	lactate metabolic process
Tbis_1137	COG0277	FAD linked oxidase domain protein
Tbis_1138	COG0277	FAD linked oxidase domain protein
Tbis_1140	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Tbis_1142	COG1596	polysaccharide export
Tbis_1142	COG1555	photosystem II stabilization
Tbis_1145	COG0268	Binds directly to 16S ribosomal RNA
Tbis_1146	COG0481	GTPase activity
Tbis_1147	COG2258	MOSC domain
Tbis_1150	COG1420	regulation of RNA biosynthetic process
Tbis_1151	COG0484	heat shock protein binding
Tbis_1155	COG0537	adenosine 5'-monophosphoramidase activity
Tbis_1157	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Tbis_1162	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Tbis_1165	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Tbis_1168	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Tbis_1169	COG1834	amidinotransferase
Tbis_1170	COG1522	sequence-specific DNA binding
Tbis_1171	COG0583	DNA-binding transcription factor activity
Tbis_1176	COG1381	Involved in DNA repair and RecF pathway recombination
Tbis_1177	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Tbis_1182	COG0423	glycine-tRNA ligase activity
Tbis_1184	COG0574	Belongs to the PEP-utilizing enzyme family
Tbis_1184	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Tbis_1185	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Tbis_1187	COG0358	DNA primase activity
Tbis_1188	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Tbis_1191	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Tbis_1194	COG1129	ABC transporter
Tbis_1198	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Tbis_1199	COG1070	Carbohydrate kinase
Tbis_1205	COG1131	(ABC) transporter
Tbis_1207	COG1028	Short-chain dehydrogenase reductase Sdr
Tbis_1209	COG1309	transcriptional regulator
Tbis_1213	COG0730	response to heat
Tbis_1214	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Tbis_1215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tbis_1221	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Tbis_1223	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Tbis_1231	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Tbis_1232	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Tbis_1233	COG1120	ATPase activity
Tbis_1235	COG1028	Short-chain dehydrogenase reductase Sdr
Tbis_1240	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Tbis_1249	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Tbis_1251	COG0477	Major facilitator Superfamily
Tbis_1252	COG1309	transcriptional regulator
Tbis_1253	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Tbis_1253	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Tbis_1256	COG2814	Major facilitator Superfamily
Tbis_1258	COG0174	glutamine synthetase
Tbis_1260	COG0505	Belongs to the CarA family
Tbis_1261	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Tbis_1264	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Tbis_1266	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Tbis_1267	COG0321	lipoyl(octanoyl) transferase activity
Tbis_1268	COG3340	Belongs to the peptidase S51 family
Tbis_1270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Tbis_1271	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Tbis_1272	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Tbis_1275	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Tbis_1278	COG0667	Aldo Keto reductase
Tbis_1282	COG0501	Belongs to the peptidase M48B family
Tbis_1284	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Tbis_1289	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Tbis_1290	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Tbis_1293	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Tbis_1294	COG0723	plastoquinol--plastocyanin reductase activity
Tbis_1296	COG1845	cytochrome c oxidase, subunit III
Tbis_1298	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Tbis_1303	COG1388	LysM domain
Tbis_1303	COG0791	NLP P60 protein
Tbis_1308	COG1940	carbohydrate kinase activity
Tbis_1313	COG0204	Acyl-transferase
Tbis_1315	COG2040	homocysteine
Tbis_1322	COG4521	taurine ABC transporter
Tbis_1323	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Tbis_1324	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Tbis_1325	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Tbis_1326	COG0205	6-phosphofructokinase activity
Tbis_1327	COG0301	tRNA thio-modification
Tbis_1328	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Tbis_1329	COG3275	phosphorelay sensor kinase activity
Tbis_1330	COG3279	Response regulator of the LytR AlgR family
Tbis_1331	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Tbis_1337	COG2815	serine threonine protein kinase
Tbis_1337	COG0515	serine threonine protein kinase
Tbis_1338	COG2022	thiamine diphosphate biosynthetic process
Tbis_1343	COG0352	thiamine-phosphate diphosphorylase activity
Tbis_1348	COG3409	Peptidoglycan-binding domain 1 protein
Tbis_1348	COG0860	N-Acetylmuramoyl-L-alanine amidase
Tbis_1351	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Tbis_1352	COG0540	Belongs to the ATCase OTCase family
Tbis_1353	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Tbis_1354	COG0505	Belongs to the CarA family
Tbis_1355	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Tbis_1356	COG0543	2 iron, 2 sulfur cluster binding
Tbis_1357	COG0167	dihydroorotate dehydrogenase activity
Tbis_1358	COG0284	orotidine-5'-phosphate decarboxylase activity
Tbis_1360	COG0194	GDP metabolic process
Tbis_1361	COG1758	RNA polymerase activity
Tbis_1363	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Tbis_1367	COG0242	peptide deformylase activity
Tbis_1368	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Tbis_1370	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Tbis_1371	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Tbis_1371	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Tbis_1373	COG3201	nicotinamide mononucleotide transporter
Tbis_1374	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Tbis_1374	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Tbis_1375	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Tbis_1378	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Tbis_1379	COG1116	anion transmembrane transporter activity
Tbis_1380	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Tbis_1383	COG0542	response to heat
Tbis_1388	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Tbis_1390	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Tbis_1391	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Tbis_1395	COG1305	Transglutaminase-like
Tbis_1397	COG0714	Associated with various cellular activities
Tbis_1398	COG2001	Belongs to the MraZ family
Tbis_1399	COG0275	rRNA processing
Tbis_1401	COG0768	penicillin binding
Tbis_1402	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Tbis_1404	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Tbis_1405	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Tbis_1407	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Tbis_1408	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Tbis_1409	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Tbis_1410	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Tbis_1412	COG1799	cell septum assembly
Tbis_1416	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Tbis_1417	COG1872	DUF167
Tbis_1419	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Tbis_1422	COG0210	DNA helicase
Tbis_1425	COG0587	DNA-directed DNA polymerase activity
Tbis_1426	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Tbis_1428	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Tbis_1430	COG0154	amidase activity
Tbis_1431	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Tbis_1432	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Tbis_1434	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Tbis_1435	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Tbis_1436	COG0131	Imidazoleglycerol-phosphate dehydratase
Tbis_1437	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Tbis_1438	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Tbis_1439	COG0251	oxidation-reduction process
Tbis_1440	COG0107	imidazoleglycerol-phosphate synthase activity
Tbis_1445	COG1132	(ABC) transporter
Tbis_1446	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Tbis_1450	COG0134	indole-3-glycerol-phosphate synthase activity
Tbis_1451	COG0133	tryptophan synthase activity
Tbis_1452	COG0159	tryptophan synthase activity
Tbis_1455	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Tbis_1458	COG0069	glutamate synthase activity
Tbis_1458	COG0067	glutamate synthase
Tbis_1458	COG0070	glutamate synthase
Tbis_1464	COG0559	Belongs to the binding-protein-dependent transport system permease family
Tbis_1465	COG0411	ABC transporter
Tbis_1466	COG0410	ABC transporter
Tbis_1469	COG0683	leucine binding
Tbis_1472	COG0411	ABC transporter
Tbis_1474	COG2050	protein possibly involved in aromatic compounds catabolism
Tbis_1477	COG0539	negative regulation of cytoplasmic translation
Tbis_1479	COG0237	dephospho-CoA kinase activity
Tbis_1485	COG0556	nucleotide-excision repair
Tbis_1486	COG0110	maltose O-acetyltransferase activity
Tbis_1487	COG0504	CTP synthase activity
Tbis_1491	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Tbis_1492	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Tbis_1496	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Tbis_1497	COG1160	GTP binding
Tbis_1498	COG0477	Major facilitator Superfamily
Tbis_1510	COG1012	belongs to the aldehyde dehydrogenase family
Tbis_1511	COG0506	proline dehydrogenase activity
Tbis_1513	COG0297	glycogen (starch) synthase activity
Tbis_1515	COG1252	NADH dehydrogenase
Tbis_1523	COG0494	nUDIX hydrolase
Tbis_1530	COG1518	maintenance of DNA repeat elements
Tbis_1538	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Tbis_1540	COG0443	Heat shock 70 kDa protein
Tbis_1544	COG0515	serine threonine protein kinase
Tbis_1550	COG0531	amino acid
Tbis_1552	COG0804	urea catabolic process
Tbis_1553	COG0832	Belongs to the urease beta subunit family
Tbis_1553	COG0831	urea catabolic process
Tbis_1554	COG1609	Transcriptional regulator
Tbis_1555	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Tbis_1556	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Tbis_1557	COG1116	anion transmembrane transporter activity
Tbis_1559	COG3693	PFAM glycoside hydrolase, family 10
Tbis_1561	COG1653	transport
Tbis_1562	COG0395	ABC-type sugar transport system, permease component
Tbis_1563	COG4209	transmembrane transport
Tbis_1572	COG1966	Carbon starvation protein
Tbis_1584	COG1028	Short-chain dehydrogenase reductase Sdr
Tbis_1585	COG0045	succinate-CoA ligase (ADP-forming) activity
Tbis_1585	COG1042	CoA-binding domain protein
Tbis_1585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Tbis_1586	COG1960	acyl-CoA dehydrogenase activity
Tbis_1587	COG3842	ATPase activity
Tbis_1588	COG1177	transmembrane transport
Tbis_1589	COG1176	ABC-type spermidine putrescine transport system, permease component I
Tbis_1594	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Tbis_1595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Tbis_1597	COG2855	membrane
Tbis_1601	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Tbis_1604	COG0318	PFAM AMP-dependent synthetase and ligase
Tbis_1606	COG0431	NADPH-dependent FMN reductase
Tbis_1608	COG1028	Short-chain dehydrogenase reductase Sdr
Tbis_1610	COG1028	Short-chain dehydrogenase reductase Sdr
Tbis_1613	COG0477	Major facilitator Superfamily
Tbis_1618	COG1703	isobutyryl-CoA mutase activity
Tbis_1618	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Tbis_1618	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Tbis_1619	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tbis_1620	COG2197	response regulator
Tbis_1621	COG1120	ATPase activity
Tbis_1622	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Tbis_1623	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Tbis_1628	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Tbis_1629	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Tbis_1629	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Tbis_1633	COG1960	acyl-CoA dehydrogenase activity
Tbis_1634	COG1309	transcriptional regulator
Tbis_1638	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Tbis_1648	COG2217	Heavy metal translocating P-type atpase
Tbis_1649	COG4109	DRTGG domain
Tbis_1652	COG2132	Multicopper oxidase
Tbis_1656	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Tbis_1658	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Tbis_1660	COG4608	Belongs to the ABC transporter superfamily
Tbis_1662	COG3876	Protein conserved in bacteria
Tbis_1663	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
Tbis_1664	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Tbis_1668	COG1515	deoxyribonuclease V activity
Tbis_1669	COG0435	Glutathione S-transferase
Tbis_1673	COG1940	carbohydrate kinase activity
Tbis_1679	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Tbis_1680	COG2183	response to ionizing radiation
Tbis_1684	COG0772	Belongs to the SEDS family
Tbis_1685	COG0768	penicillin binding
Tbis_1686	COG1792	Involved in formation and maintenance of cell shape
Tbis_1692	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Tbis_1693	COG1716	ATPase activity
Tbis_1697	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Tbis_1697	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Tbis_1707	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
Tbis_1708	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
Tbis_1714	COG1132	(ABC) transporter
Tbis_1715	COG4988	ABC transporter
Tbis_1716	COG1739	Uncharacterized protein family UPF0029
Tbis_1717	COG1169	isochorismate synthase
Tbis_1720	COG2197	response regulator
Tbis_1721	COG4585	Histidine kinase
Tbis_1723	COG1131	(ABC) transporter
Tbis_1724	COG0438	transferase activity, transferring glycosyl groups
Tbis_1729	COG2261	transglycosylase associated protein
Tbis_1731	COG0697	spore germination
Tbis_1740	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Tbis_1741	COG1012	belongs to the aldehyde dehydrogenase family
Tbis_1742	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Tbis_1745	COG1960	acyl-CoA dehydrogenase activity
Tbis_1746	COG0492	ferredoxin-NADP+ reductase activity
Tbis_1749	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Tbis_1750	COG0022	dehydrogenase e1 component
Tbis_1751	COG0508	dehydrogenase complex catalyzes the overall conversion of
Tbis_1752	COG0475	glutathione-regulated potassium exporter activity
Tbis_1757	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Tbis_1762	COG2076	Multidrug Resistance protein
Tbis_1763	COG1309	transcriptional regulator
Tbis_1764	COG0842	Transport permease protein
Tbis_1766	COG1131	(ABC) transporter
Tbis_1769	COG4565	transcriptional regulatory protein
Tbis_1771	COG2197	response regulator
Tbis_1774	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Tbis_1775	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Tbis_1780	COG4974	Belongs to the 'phage' integrase family
Tbis_1781	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Tbis_1783	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Tbis_1784	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Tbis_1790	COG1280	lysine exporter protein (LysE YggA)
Tbis_1792	COG2223	nitrite transmembrane transporter activity
Tbis_1795	COG0714	Associated with various cellular activities
Tbis_1798	COG2813	Specifically methylates the guanine in position
Tbis_1799	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Tbis_1800	COG0584	glycerophosphoryl diester phosphodiesterase
Tbis_1803	COG0583	DNA-binding transcription factor activity
Tbis_1804	COG1960	acyl-CoA dehydrogenase activity
Tbis_1807	COG0463	Glycosyl transferase, family 2
Tbis_1813	COG1522	sequence-specific DNA binding
Tbis_1814	COG1960	acyl-CoA dehydrogenase activity
Tbis_1819	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Tbis_1822	COG0805	protein transport
Tbis_1823	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Tbis_1828	COG0545	Peptidyl-prolyl cis-trans isomerase
Tbis_1829	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Tbis_1831	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Tbis_1832	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Tbis_1836	COG4122	O-methyltransferase activity
Tbis_1838	COG1222	aaa ATPase
Tbis_1840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Tbis_1843	COG1994	Peptidase M50
Tbis_1843	COG0517	IMP dehydrogenase activity
Tbis_1845	COG4585	Histidine kinase
Tbis_1846	COG2197	response regulator
Tbis_1847	COG4608	Belongs to the ABC transporter superfamily
Tbis_1848	COG0444	Belongs to the ABC transporter superfamily
Tbis_1853	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Tbis_1854	COG0646	methionine synthase
Tbis_1854	COG1410	methionine synthase
Tbis_1856	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Tbis_1860	COG0543	2 iron, 2 sulfur cluster binding
Tbis_1863	COG0463	Glycosyl transferase, family 2
Tbis_1884	COG3833	ABC-type maltose transport systems, permease component
Tbis_1889	COG2205	protein histidine kinase activity
Tbis_1890	COG3119	arylsulfatase activity
Tbis_1892	COG1175	transmembrane transport
Tbis_1893	COG0395	ABC-type sugar transport system, permease component
Tbis_1894	COG2723	6-phospho-beta-galactosidase activity
Tbis_1896	COG2723	6-phospho-beta-galactosidase activity
Tbis_1897	COG2017	converts alpha-aldose to the beta-anomer
Tbis_1898	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Tbis_1899	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
Tbis_1901	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Tbis_1902	COG0589	response to stress
Tbis_1906	COG1464	Belongs to the NlpA lipoprotein family
Tbis_1907	COG2011	ABC-type metal ion transport system permease component
Tbis_1908	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Tbis_1910	COG3540	Alkaline phosphatase
Tbis_1914	COG0672	)-iron permease
Tbis_1916	COG2837	iron assimilation
Tbis_1922	COG4133	protoheme IX ABC transporter activity
Tbis_1932	COG0215	cysteine-tRNA ligase activity
Tbis_1937	COG1968	undecaprenyl-diphosphatase activity
Tbis_1938	COG0667	Aldo Keto reductase
Tbis_1940	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Tbis_1941	COG1028	Short-chain dehydrogenase reductase Sdr
Tbis_1944	COG3360	Dodecin
Tbis_1946	COG0746	molybdenum cofactor guanylyltransferase activity
Tbis_1947	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Tbis_1954	COG3104	oligopeptide transport
Tbis_1955	COG3387	PFAM Glycoside hydrolase 15-related
Tbis_1956	COG1619	proteins homologs of microcin C7 resistance protein MccF
Tbis_1958	COG1132	(ABC) transporter
Tbis_1961	COG0488	(ABC) transporter
Tbis_1963	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Tbis_1964	COG0140	phosphoribosyl-ATP diphosphatase activity
Tbis_1965	COG3458	cephalosporin-C deacetylase activity
Tbis_1966	COG2151	metal-sulfur cluster biosynthetic enzyme
Tbis_1967	COG0822	iron-sulfur transferase activity
Tbis_1968	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Tbis_1969	COG0396	ATPase activity
Tbis_1970	COG2146	nitrite reductase [NAD(P)H] activity
Tbis_1971	COG0719	Fe-S assembly protein
Tbis_1974	COG1131	(ABC) transporter
Tbis_1976	COG5006	permease, DMT superfamily
Tbis_1979	COG0109	protoheme IX farnesyltransferase activity
Tbis_1981	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Tbis_1982	COG0166	Belongs to the GPI family
Tbis_1985	COG0363	glucosamine-6-phosphate deaminase activity
Tbis_1986	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Tbis_1986	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Tbis_1990	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Tbis_1991	COG0149	triose-phosphate isomerase activity
Tbis_1992	COG0126	phosphoglycerate kinase activity
Tbis_1993	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Tbis_1994	COG1481	regulation of sporulation
Tbis_1996	COG1660	Displays ATPase and GTPase activities
Tbis_1997	COG0322	excinuclease ABC activity
Tbis_1999	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Tbis_2001	COG4948	Mandelate Racemase Muconate Lactonizing
Tbis_2004	COG0688	phosphatidylethanolamine metabolic process
Tbis_2005	COG0861	Integral membrane protein TerC family
Tbis_2006	COG0297	glycogen (starch) synthase activity
Tbis_2011	COG0497	DNA recombination
Tbis_2012	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Tbis_2016	COG0647	UMP catabolic process
Tbis_2021	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Tbis_2022	COG3401	FG-GAP repeat protein
Tbis_2023	COG2094	Belongs to the DNA glycosylase MPG family
Tbis_2024	COG0165	Argininosuccinate lyase
Tbis_2025	COG0137	argininosuccinate synthase activity
Tbis_2026	COG1438	arginine binding
Tbis_2027	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Tbis_2028	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Tbis_2029	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Tbis_2030	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Tbis_2031	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Tbis_2032	COG0318	PFAM AMP-dependent synthetase and ligase
Tbis_2036	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tbis_2036	COG0072	phenylalanine-tRNA ligase activity
Tbis_2037	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Tbis_2038	COG5002	protein histidine kinase activity
Tbis_2039	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Tbis_2040	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Tbis_2042	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Tbis_2043	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Tbis_2044	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Tbis_2046	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Tbis_2047	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Tbis_2052	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Tbis_2053	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Tbis_2054	COG0124	histidyl-tRNA synthetase
Tbis_2056	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Tbis_2057	COG1196	nuclear chromosome segregation
Tbis_2058	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Tbis_2059	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Tbis_2060	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Tbis_2061	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Tbis_2062	COG1862	Preprotein translocase
Tbis_2063	COG2255	four-way junction helicase activity
Tbis_2064	COG0632	four-way junction helicase activity
Tbis_2065	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Tbis_2066	COG0217	transcriptional regulatory protein
Tbis_2067	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
Tbis_2069	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Tbis_2072	COG0438	transferase activity, transferring glycosyl groups
Tbis_2073	COG1560	Kdo2-lipid A biosynthetic process
Tbis_2076	COG1649	PFAM Uncharacterised BCR, COG1649
Tbis_2078	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Tbis_2079	COG0667	Aldo Keto reductase
Tbis_2083	COG0318	PFAM AMP-dependent synthetase and ligase
Tbis_2084	COG2197	response regulator
Tbis_2086	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
Tbis_2088	COG1733	regulation of RNA biosynthetic process
Tbis_2089	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tbis_2090	COG1024	Enoyl-CoA hydratase
Tbis_2091	COG1960	acyl-CoA dehydrogenase activity
Tbis_2092	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tbis_2096	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Tbis_2097	COG0512	Glutamine amidotransferase of anthranilate synthase
Tbis_2097	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Tbis_2098	COG0583	DNA-binding transcription factor activity
Tbis_2100	COG2986	histidine ammonia-lyase
Tbis_2102	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Tbis_2104	COG1309	transcriptional regulator
Tbis_2107	COG3851	Histidine kinase
Tbis_2110	COG2124	cytochrome p450
Tbis_2112	COG0297	glycogen (starch) synthase activity
Tbis_2113	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Tbis_2118	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Tbis_2122	COG0243	molybdopterin cofactor binding
Tbis_2125	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Tbis_2126	COG1796	DNA polymerase
Tbis_2126	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Tbis_2129	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Tbis_2131	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Tbis_2133	COG3279	Response regulator of the LytR AlgR family
Tbis_2134	COG3275	phosphorelay sensor kinase activity
Tbis_2141	COG1597	lipid kinase activity
Tbis_2143	COG0277	FAD linked oxidase domain protein
Tbis_2144	COG1024	Enoyl-CoA hydratase
Tbis_2147	COG2313	pseudouridylate synthase activity
Tbis_2151	COG1960	acyl-CoA dehydrogenase activity
Tbis_2154	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Tbis_2156	COG0022	dehydrogenase e1 component
Tbis_2166	COG0419	ATPase involved in DNA repair
Tbis_2167	COG0420	3'-5' exonuclease activity
Tbis_2169	COG1316	TRANSCRIPTIONal
Tbis_2170	COG4948	Mandelate Racemase Muconate Lactonizing
Tbis_2171	COG3552	Protein containing von Willebrand factor type A (VWA) domain
Tbis_2173	COG0714	Associated with various cellular activities
Tbis_2176	COG1012	belongs to the aldehyde dehydrogenase family
Tbis_2198	COG3842	ATPase activity
Tbis_2207	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Tbis_2208	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Tbis_2209	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Tbis_2210	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Tbis_2214	COG0549	Belongs to the carbamate kinase family
Tbis_2215	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Tbis_2216	COG0450	alkyl hydroperoxide reductase
Tbis_2219	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Tbis_2231	COG2233	PERMEase
Tbis_2234	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Tbis_2235	COG1304	FMN binding
Tbis_2236	COG2815	serine threonine protein kinase
Tbis_2236	COG0515	serine threonine protein kinase
Tbis_2238	COG0277	FAD linked oxidase domain protein
Tbis_2242	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Tbis_2244	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Tbis_2246	COG0175	sulfate reduction
Tbis_2251	COG1960	acyl-CoA dehydrogenase activity
Tbis_2256	COG1793	dna ligase
Tbis_2259	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Tbis_2264	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Tbis_2266	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Tbis_2267	COG0183	Belongs to the thiolase family
Tbis_2268	COG1024	Enoyl-CoA hydratase
Tbis_2268	COG1250	3-hydroxyacyl-CoA dehydrogenase
Tbis_2269	COG0531	amino acid
Tbis_2270	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Tbis_2271	COG1940	carbohydrate kinase activity
Tbis_2272	COG4214	carbohydrate transport
Tbis_2274	COG4213	ABC transporter substrate-binding protein
Tbis_2276	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Tbis_2283	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Tbis_2284	COG0531	amino acid
Tbis_2285	COG0569	domain protein
Tbis_2290	COG0756	dUTP diphosphatase activity
Tbis_2292	COG0525	valine-tRNA ligase activity
Tbis_2294	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
Tbis_2297	COG2205	protein histidine kinase activity
Tbis_2298	COG0745	RESPONSE REGULATOR receiver
Tbis_2302	COG0739	heme binding
Tbis_2308	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Tbis_2311	COG0406	alpha-ribazole phosphatase activity
Tbis_2311	COG0328	RNA-DNA hybrid ribonuclease activity
Tbis_2312	COG1579	Zn-ribbon protein possibly nucleic acid-binding
Tbis_2313	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Tbis_2314	COG2205	protein histidine kinase activity
Tbis_2316	COG3396	Phenylacetate-CoA oxygenase
Tbis_2317	COG0300	oxidoreductase activity
Tbis_2319	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
Tbis_2320	COG1609	Transcriptional regulator
Tbis_2330	COG1643	Atp-dependent helicase
Tbis_2331	COG0745	RESPONSE REGULATOR receiver
Tbis_2339	COG1404	Belongs to the peptidase S8 family
Tbis_2343	COG3173	Aminoglycoside phosphotransferase
Tbis_2348	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Tbis_2360	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Tbis_2364	COG3766	membrane
Tbis_2370	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Tbis_2371	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Tbis_2385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Tbis_2387	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Tbis_2394	COG0187	DNA topoisomerase II activity
Tbis_2398	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Tbis_2398	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Tbis_2399	COG5001	Diguanylate cyclase
Tbis_2401	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Tbis_2405	COG1609	Transcriptional regulator
Tbis_2406	COG1472	Belongs to the glycosyl hydrolase 3 family
Tbis_2407	COG1940	carbohydrate kinase activity
Tbis_2416	COG1501	Belongs to the glycosyl hydrolase 31 family
Tbis_2427	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Tbis_2428	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Tbis_2429	COG0495	leucyl-tRNA aminoacylation
Tbis_2432	COG0318	PFAM AMP-dependent synthetase and ligase
Tbis_2433	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Tbis_2443	COG0424	maF-like protein
Tbis_2446	COG1492	cobalamin metabolic process
Tbis_2447	COG1028	Short-chain dehydrogenase reductase Sdr
Tbis_2453	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Tbis_2454	COG0501	Belongs to the peptidase M48B family
Tbis_2456	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Tbis_2457	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Tbis_2458	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Tbis_2459	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Tbis_2460	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Tbis_2461	COG1530	ribonuclease E activity
Tbis_2464	COG0772	Belongs to the SEDS family
Tbis_2465	COG0768	penicillin binding
Tbis_2468	COG1077	Cell shape determining protein MreB Mrl
Tbis_2469	COG0105	UTP biosynthetic process
Tbis_2472	COG0285	dihydrofolate synthase activity
Tbis_2474	COG0525	valine-tRNA ligase activity
Tbis_2475	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Tbis_2476	COG0740	serine-type endopeptidase activity
Tbis_2477	COG0740	serine-type endopeptidase activity
Tbis_2478	COG0544	peptidyl-prolyl cis-trans isomerase activity
Tbis_2482	COG1434	Gram-negative-bacterium-type cell wall biogenesis
Tbis_2491	COG1797	cobyrinic acid a,c-diamide synthase activity
Tbis_2492	COG1799	cell septum assembly
Tbis_2505	COG0582	viral genome integration into host DNA
Tbis_2507	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Tbis_2509	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Tbis_2515	COG0318	PFAM AMP-dependent synthetase and ligase
Tbis_2517	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Tbis_2522	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Tbis_2523	COG2267	carboxylic ester hydrolase activity
Tbis_2524	COG1028	Short-chain dehydrogenase reductase Sdr
Tbis_2528	COG0750	zinc metalloprotease
Tbis_2532	COG0242	peptide deformylase activity
Tbis_2536	COG0154	amidase activity
Tbis_2538	COG0129	dihydroxy-acid dehydratase activity
Tbis_2543	COG1505	serine-type exopeptidase activity
Tbis_2549	COG0668	transmembrane transport
Tbis_2556	COG0590	tRNA wobble adenosine to inosine editing
Tbis_2558	COG0629	single-stranded DNA binding
Tbis_2561	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Tbis_2561	COG1648	precorrin-2 dehydrogenase activity
Tbis_2562	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Tbis_2567	COG0583	DNA-binding transcription factor activity
Tbis_2570	COG0587	DNA-directed DNA polymerase activity
Tbis_2573	COG0574	Belongs to the PEP-utilizing enzyme family
Tbis_2573	COG3848	Pyruvate phosphate dikinase
Tbis_2576	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Tbis_2580	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Tbis_2581	COG1609	Transcriptional regulator
Tbis_2584	COG1172	Belongs to the binding-protein-dependent transport system permease family
Tbis_2588	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Tbis_2589	COG4266	Belongs to the allantoicase family
Tbis_2590	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Tbis_2591	COG1929	Belongs to the glycerate kinase type-1 family
Tbis_2600	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Tbis_2601	COG1984	allophanate hydrolase subunit 2
Tbis_2603	COG1760	l-serine dehydratase
Tbis_2605	COG2723	6-phospho-beta-galactosidase activity
Tbis_2606	COG1012	belongs to the aldehyde dehydrogenase family
Tbis_2607	COG0028	Belongs to the TPP enzyme family
Tbis_2608	COG0477	Major facilitator Superfamily
Tbis_2610	COG0804	urea catabolic process
Tbis_2611	COG0831	urea catabolic process
Tbis_2611	COG0832	Belongs to the urease beta subunit family
Tbis_2615	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Tbis_2615	COG3608	succinylglutamate desuccinylase aspartoacylase
Tbis_2617	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Tbis_2625	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
Tbis_2628	COG1595	DNA-templated transcription, initiation
Tbis_2629	COG2852	Protein conserved in bacteria
Tbis_2636	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Tbis_2639	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Tbis_2639	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Tbis_2640	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Tbis_2641	COG0297	glycogen (starch) synthase activity
Tbis_2642	COG0859	PFAM glycosyl transferase family 9
Tbis_2644	COG2192	nodulation
Tbis_2645	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Tbis_2649	COG0121	glutamine amidotransferase
Tbis_2650	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Tbis_2651	COG3572	ergothioneine biosynthetic process
Tbis_2654	COG0640	Transcriptional regulator
Tbis_2656	COG5297	Belongs to the glycosyl hydrolase family 6
Tbis_2659	COG0039	L-malate dehydrogenase activity
Tbis_2664	COG0215	cysteine-tRNA ligase activity
Tbis_2667	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Tbis_2669	COG3903	Transcriptional regulator
Tbis_2669	COG3629	intracellular signal transduction
Tbis_2676	COG0726	polysaccharide deacetylase
Tbis_2676	COG1649	PFAM Uncharacterised BCR, COG1649
Tbis_2680	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
Tbis_2681	COG2197	response regulator
Tbis_2690	COG0725	ABC transporter, periplasmic molybdate-binding protein
Tbis_2692	COG0783	Belongs to the Dps family
Tbis_2697	COG1960	acyl-CoA dehydrogenase activity
Tbis_2698	COG1960	acyl-CoA dehydrogenase activity
Tbis_2699	COG1960	acyl-CoA dehydrogenase activity
Tbis_2703	COG0653	protein targeting
Tbis_2705	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Tbis_2710	COG0517	IMP dehydrogenase activity
Tbis_2710	COG0516	GMP reductase activity
Tbis_2711	COG2239	Acts as a magnesium transporter
Tbis_2714	COG1653	transport
Tbis_2716	COG0395	ABC-type sugar transport system, permease component
Tbis_2728	COG0210	DNA helicase
Tbis_2729	COG1205	dead DEAH box helicase
Tbis_2729	COG1111	helicase
Tbis_2730	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Tbis_2731	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Tbis_2732	COG2814	Major facilitator Superfamily
Tbis_2734	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
Tbis_2747	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
Tbis_2748	COG4988	ABC transporter
Tbis_2749	COG1294	oxidase, subunit
Tbis_2750	COG1271	oxidase subunit
Tbis_2754	COG2130	NADP-dependent
Tbis_2755	COG1950	PFAM Membrane protein of
Tbis_2757	COG2807	transmembrane transport
Tbis_2760	COG1414	Transcriptional regulator
Tbis_2761	COG0667	Aldo Keto reductase
Tbis_2768	COG0433	COG0433 Predicted ATPase
Tbis_2769	COG0726	polysaccharide deacetylase
Tbis_2770	COG1476	TRANSCRIPTIONal
Tbis_2772	COG1595	DNA-templated transcription, initiation
Tbis_2776	COG1196	nuclear chromosome segregation
Tbis_2778	COG1254	Belongs to the acylphosphatase family
Tbis_2779	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Tbis_2780	COG0571	ribonuclease III activity
Tbis_2781	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Tbis_2783	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Tbis_2784	COG0742	ribosomal rna small subunit methyltransferase
Tbis_2786	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Tbis_2787	COG0351	phosphomethylpyrimidine kinase
Tbis_2792	COG1181	Belongs to the D-alanine--D-alanine ligase family
Tbis_2793	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Tbis_2796	COG0477	Major facilitator Superfamily
Tbis_2800	COG0776	regulation of translation
Tbis_2801	COG0066	3-isopropylmalate dehydratase activity
Tbis_2802	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Tbis_2803	COG1414	Transcriptional regulator
Tbis_2805	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Tbis_2806	COG0179	Fumarylacetoacetate (FAA) hydrolase
Tbis_2809	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Tbis_2811	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Tbis_2812	COG0473	3-isopropylmalate dehydrogenase activity
Tbis_2814	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Tbis_2816	COG2211	Major facilitator Superfamily
Tbis_2817	COG2340	Cysteine-rich secretory protein family
Tbis_2819	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Tbis_2820	COG0440	acetolactate synthase activity
Tbis_2822	COG5001	Diguanylate cyclase
Tbis_2822	COG3300	MHYT domain
Tbis_2823	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Tbis_2824	COG2133	pyrroloquinoline quinone binding
Tbis_2826	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Tbis_2827	COG0154	amidase activity
Tbis_2828	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Tbis_2832	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Tbis_2833	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Tbis_2835	COG3485	protocatechuate 3,4-dioxygenase
Tbis_2836	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
Tbis_2837	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
Tbis_2838	COG1414	Transcriptional regulator
Tbis_2839	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Tbis_2841	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tbis_2842	COG0482	sulfurtransferase activity
Tbis_2845	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Tbis_2848	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Tbis_2848	COG0515	serine threonine protein kinase
Tbis_2851	COG2362	D-Aminopeptidase
Tbis_2854	COG1024	Enoyl-CoA hydratase
Tbis_2855	COG0438	transferase activity, transferring glycosyl groups
Tbis_2857	COG0058	SHG alpha-glucan phosphorylase activity
Tbis_2858	COG0366	Alpha amylase catalytic
Tbis_2860	COG3281	Trehalose synthase
Tbis_2861	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Tbis_2863	COG0616	signal peptide processing
Tbis_2867	COG0318	PFAM AMP-dependent synthetase and ligase
Tbis_2871	COG1309	transcriptional regulator
Tbis_2873	COG0438	transferase activity, transferring glycosyl groups
Tbis_2874	COG2226	methyltransferase
Tbis_2881	COG0673	inositol 2-dehydrogenase activity
Tbis_2882	COG4213	ABC transporter substrate-binding protein
Tbis_2883	COG1172	Belongs to the binding-protein-dependent transport system permease family
Tbis_2884	COG1129	ABC transporter
Tbis_2885	COG1940	carbohydrate kinase activity
Tbis_2890	COG0567	Dehydrogenase, E1 component
Tbis_2890	COG0508	dehydrogenase complex catalyzes the overall conversion of
Tbis_2893	COG0604	alcohol dehydrogenase
Tbis_2896	COG0488	(ABC) transporter
Tbis_2904	COG2172	sigma factor antagonist activity
Tbis_2911	COG2188	Transcriptional regulator
Tbis_2915	COG0515	serine threonine protein kinase
Tbis_2917	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
Tbis_2923	COG1595	DNA-templated transcription, initiation
Tbis_2926	COG2135	peptidase activity
Tbis_2927	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Tbis_2929	COG0483	inositol monophosphate 1-phosphatase activity
Tbis_2932	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Tbis_2935	COG0581	inorganic phosphate transmembrane transporter activity
Tbis_2936	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Tbis_2938	COG0747	negative chemotaxis
Tbis_2947	COG0601	transmembrane transport
Tbis_2948	COG0747	negative chemotaxis
Tbis_2952	COG1615	UPF0182 protein
Tbis_2953	COG3480	Lon protease (S16) C-terminal proteolytic domain
Tbis_2961	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Tbis_2964	COG1946	Acyl-CoA thioesterase
Tbis_2970	COG4264	IucA IucC family
Tbis_2972	COG0019	diaminopimelate decarboxylase activity
Tbis_2974	COG0210	DNA helicase
Tbis_2975	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
Tbis_2978	COG1404	Belongs to the peptidase S8 family
Tbis_2980	COG1404	Belongs to the peptidase S8 family
Tbis_2990	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
Tbis_2991	COG3285	dna ligase
Tbis_2991	COG1793	dna ligase
Tbis_2996	COG0513	Belongs to the DEAD box helicase family
Tbis_3001	COG0494	nUDIX hydrolase
Tbis_3003	COG1266	CAAX protease self-immunity
Tbis_3004	COG2301	Belongs to the HpcH HpaI aldolase family
Tbis_3005	COG1268	BioY protein
Tbis_3009	COG2239	Acts as a magnesium transporter
Tbis_3012	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Tbis_3014	COG1595	DNA-templated transcription, initiation
Tbis_3016	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Tbis_3018	COG1024	Enoyl-CoA hydratase
Tbis_3019	COG0519	Catalyzes the synthesis of GMP from XMP
Tbis_3022	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Tbis_3024	COG1611	Belongs to the LOG family
Tbis_3030	COG4106	trans-aconitate 2-methyltransferase activity
Tbis_3032	COG0210	DNA helicase
Tbis_3034	COG0215	cysteine-tRNA ligase activity
Tbis_3036	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Tbis_3050	COG1053	succinate dehydrogenase
Tbis_3053	COG0494	nUDIX hydrolase
Tbis_3054	COG0791	NLP P60 protein
Tbis_3054	COG1388	LysM domain
Tbis_3062	COG0012	GTP binding
Tbis_3063	COG1322	Protein conserved in bacteria
Tbis_3065	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Tbis_3067	COG1570	exodeoxyribonuclease VII activity
Tbis_3068	COG0367	asparagine synthase
Tbis_3069	COG1722	exodeoxyribonuclease VII activity
Tbis_3075	COG3962	Belongs to the TPP enzyme family
Tbis_3076	COG3718	enzyme involved in inositol metabolism
Tbis_3078	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Tbis_3080	COG0673	inositol 2-dehydrogenase activity
Tbis_3083	COG0515	serine threonine protein kinase
Tbis_3084	COG2815	serine threonine protein kinase
Tbis_3084	COG0515	serine threonine protein kinase
Tbis_3085	COG0114	fumarate hydratase activity
Tbis_3087	COG1215	transferase activity, transferring glycosyl groups
Tbis_3089	COG0745	RESPONSE REGULATOR receiver
Tbis_3090	COG2205	protein histidine kinase activity
Tbis_3092	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Tbis_3093	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Tbis_3094	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
Tbis_3096	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Tbis_3098	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Tbis_3106	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Tbis_3108	COG3185	4-Hydroxyphenylpyruvate dioxygenase
Tbis_3111	COG0180	Tryptophanyl-tRNA synthetase
Tbis_3112	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Tbis_3114	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
Tbis_3115	COG4867	von Willebrand factor, type A
Tbis_3121	COG0183	Belongs to the thiolase family
Tbis_3125	COG2205	protein histidine kinase activity
Tbis_3126	COG0477	Major facilitator Superfamily
Tbis_3132	COG0148	phosphopyruvate hydratase activity
Tbis_3137	COG0529	Catalyzes the synthesis of activated sulfate
Tbis_3142	COG0515	serine threonine protein kinase
Tbis_3142	COG2815	serine threonine protein kinase
Tbis_3150	COG1218	3'(2'),5'-bisphosphate nucleotidase
Tbis_3151	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Tbis_3152	COG0193	aminoacyl-tRNA hydrolase activity
Tbis_3153	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Tbis_3154	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Tbis_3155	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Tbis_3157	COG1309	transcriptional regulator
Tbis_3158	COG4106	trans-aconitate 2-methyltransferase activity
Tbis_3159	COG1846	Transcriptional regulator
Tbis_3161	COG0488	(ABC) transporter
Tbis_3165	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Tbis_3166	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Tbis_3167	COG0084	hydrolase, TatD family'
Tbis_3169	COG2132	Multicopper oxidase
Tbis_3171	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tbis_3184	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Tbis_3185	COG0521	Mo-molybdopterin cofactor biosynthetic process
Tbis_3186	COG0315	cyclic pyranopterin monophosphate synthase activity
Tbis_3188	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Tbis_3189	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Tbis_3190	COG3263	regulation of cellular component size
Tbis_3192	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Tbis_3198	COG1252	NADH dehydrogenase
Tbis_3199	COG1595	DNA-templated transcription, initiation
Tbis_3200	COG1309	transcriptional regulator
Tbis_3201	COG1131	(ABC) transporter
Tbis_3202	COG3559	Exporter of polyketide antibiotics
Tbis_3203	COG1960	acyl-CoA dehydrogenase activity
Tbis_3204	COG0477	Major facilitator Superfamily
Tbis_3206	COG1960	acyl-CoA dehydrogenase activity
Tbis_3207	COG1024	Enoyl-CoA hydratase
Tbis_3208	COG0154	amidase activity
Tbis_3210	COG2267	carboxylic ester hydrolase activity
Tbis_3211	COG0318	PFAM AMP-dependent synthetase and ligase
Tbis_3217	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Tbis_3218	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
Tbis_3219	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Tbis_3220	COG0375	protein maturation
Tbis_3225	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Tbis_3234	COG0309	Hydrogenase expression formation protein (HypE)
Tbis_3235	COG0298	carbon dioxide binding
Tbis_3236	COG0409	Hydrogenase expression formation protein
Tbis_3239	COG1063	alcohol dehydrogenase
Tbis_3243	COG0247	lactate metabolic process
Tbis_3244	COG1139	Iron-sulfur cluster binding protein
Tbis_3245	COG1556	Lactate utilization protein
Tbis_3249	COG0395	ABC-type sugar transport system, permease component
Tbis_3250	COG1175	transmembrane transport
Tbis_3261	COG0477	Major facilitator Superfamily
Tbis_3262	COG0662	Cupin 2, conserved barrel domain protein
Tbis_3265	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Tbis_3267	COG0745	RESPONSE REGULATOR receiver
Tbis_3269	COG0577	efflux transmembrane transporter activity
Tbis_3269	COG1136	(ABC) transporter
Tbis_3270	COG1136	(ABC) transporter
Tbis_3275	COG2205	protein histidine kinase activity
Tbis_3276	COG0745	RESPONSE REGULATOR receiver
Tbis_3277	COG0579	oxidoreductase
Tbis_3281	COG1695	Transcriptional regulator
Tbis_3284	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Tbis_3286	COG0667	Aldo Keto reductase
Tbis_3290	COG2252	PERMEase
Tbis_3294	COG1278	Cold shock
Tbis_3296	COG1061	Type III restriction enzyme res subunit
Tbis_3297	COG3973	AAA domain
Tbis_3298	COG0459	protein refolding
Tbis_3300	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Tbis_3306	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
Tbis_3307	COG4608	Belongs to the ABC transporter superfamily
Tbis_3310	COG0601	transmembrane transport
Tbis_3313	COG1134	teichoic acid transport
Tbis_3314	COG1881	PFAM PEBP family protein
Tbis_3318	COG0416	fatty acid biosynthetic process
Tbis_3319	COG0018	arginyl-trna synthetase
Tbis_3321	COG1799	cell septum assembly
Tbis_3324	COG0243	molybdopterin cofactor binding
Tbis_3327	COG1960	acyl-CoA dehydrogenase activity
Tbis_3330	COG0508	dehydrogenase complex catalyzes the overall conversion of
Tbis_3331	COG0022	dehydrogenase e1 component
Tbis_3334	COG0477	Major facilitator Superfamily
Tbis_3336	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Tbis_3338	COG0047	phosphoribosylformylglycinamidine synthase activity
Tbis_3339	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Tbis_3344	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Tbis_3349	COG1309	transcriptional regulator
Tbis_3352	COG0860	N-Acetylmuramoyl-L-alanine amidase
Tbis_3353	COG3525	Glycosyl hydrolase, family 20, catalytic domain
Tbis_3359	COG0167	dihydroorotate dehydrogenase activity
Tbis_3367	COG1960	acyl-CoA dehydrogenase activity
Tbis_3369	COG0730	response to heat
Tbis_3370	COG1797	cobyrinic acid a,c-diamide synthase activity
Tbis_3372	COG2205	protein histidine kinase activity
Tbis_3373	COG3189	MarR family transcriptional regulator
Tbis_3379	COG1302	Protein conserved in bacteria
Tbis_3390	COG2197	response regulator
Tbis_3394	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
Tbis_3397	COG2188	Transcriptional regulator
Tbis_3404	COG1937	Protein conserved in bacteria
Tbis_3405	COG0438	transferase activity, transferring glycosyl groups
Tbis_3407	COG0247	lactate metabolic process
Tbis_3407	COG2181	nitrate reductase activity
Tbis_3408	COG1309	transcriptional regulator
Tbis_3409	COG2226	methyltransferase
Tbis_3410	COG1082	Xylose isomerase domain protein TIM barrel
Tbis_3411	COG2226	methyltransferase
Tbis_3412	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Tbis_3414	COG1194	a g-specific adenine glycosylase
Tbis_3416	COG0542	response to heat
Tbis_3419	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Tbis_3422	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Tbis_3423	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Tbis_3424	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Tbis_3425	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Tbis_3426	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Tbis_3435	COG1131	(ABC) transporter
Tbis_3438	COG2124	cytochrome p450
Tbis_3439	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Tbis_3440	COG0649	NAD binding
Tbis_3442	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Tbis_3443	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Tbis_3445	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Tbis_3446	COG0302	gtp cyclohydrolase
Tbis_3447	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Tbis_3449	COG0037	tRNA processing
Tbis_3452	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Tbis_3453	COG0791	NLP P60 protein
Tbis_3453	COG3883	PFAM NLP P60 protein
Tbis_3455	COG3268	Saccharopine dehydrogenase
Tbis_3459	COG0076	glutamate decarboxylase activity
Tbis_3460	COG3486	L-lysine 6-monooxygenase (NADPH) activity
Tbis_3465	COG1774	PSP1 C-terminal conserved region
Tbis_3466	COG0470	DNA polymerase III
Tbis_3467	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Tbis_3468	COG1408	metallophosphoesterase
Tbis_3469	COG1754	DNA topoisomerase type I activity
Tbis_3469	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Tbis_3473	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Tbis_3480	COG1131	(ABC) transporter
Tbis_3494	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Tbis_3496	COG1120	ATPase activity
Tbis_3497	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Tbis_3503	COG2815	serine threonine protein kinase
Tbis_3503	COG0515	serine threonine protein kinase
Tbis_3507	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Tbis_3511	COG1482	cell wall glycoprotein biosynthetic process
Tbis_3513	COG1609	Transcriptional regulator
Tbis_3516	COG0515	serine threonine protein kinase
Tbis_3516	COG2815	serine threonine protein kinase
Tbis_3521	COG2890	protein-(glutamine-N5) methyltransferase activity
Tbis_3522	COG1309	transcriptional regulator
Tbis_3526	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Tbis_3530	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Tbis_3531	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Tbis_3536	COG0590	tRNA wobble adenosine to inosine editing
Tbis_3539	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Tbis_3543	COG2186	Transcriptional regulator
Tbis_3544	COG0592	DNA-directed DNA polymerase activity
Tbis_3545	COG2197	response regulator
Tbis_3547	COG1131	(ABC) transporter
Tbis_3550	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
Tbis_3552	COG1733	regulation of RNA biosynthetic process
Tbis_3553	COG0305	Participates in initiation and elongation during chromosome replication
Tbis_3554	COG0534	Mate efflux family protein
Tbis_3556	COG0765	amino acid transport
Tbis_3558	COG0359	binds to the 23S rRNA
Tbis_3559	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Tbis_3561	COG0360	Binds together with S18 to 16S ribosomal RNA
Tbis_3566	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Tbis_3569	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
Tbis_3571	COG0617	tRNA 3'-terminal CCA addition
Tbis_3575	COG2815	serine threonine protein kinase
Tbis_3575	COG0515	serine threonine protein kinase
Tbis_3576	COG1595	DNA-templated transcription, initiation
Tbis_3578	COG0492	ferredoxin-NADP+ reductase activity
Tbis_3579	COG3118	belongs to the thioredoxin family
Tbis_3581	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Tbis_3582	COG1181	Belongs to the D-alanine--D-alanine ligase family
Tbis_3584	COG1695	Transcriptional regulator
Tbis_3589	COG1192	Involved in chromosome partitioning
Tbis_3590	COG0357	Ribosomal RNA small subunit methyltransferase G
Tbis_3593	COG0706	membrane insertase activity
Tbis_3595	COG0594	ribonuclease P activity
Tbis_3596	COG0230	Belongs to the bacterial ribosomal protein bL34 family