locus-tag	class	description
A3L01_00010	COG1131	(ABC) transporter
A3L01_00035	COG0516	GMP reductase activity
A3L01_00035	COG0517	IMP dehydrogenase activity
A3L01_00040	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A3L01_00045	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A3L01_00050	COG0157	Belongs to the NadC ModD family
A3L01_00055	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
A3L01_00065	COG3383	formate dehydrogenase (NAD+) activity
A3L01_00080	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A3L01_00085	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A3L01_00095	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A3L01_00100	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A3L01_00105	COG0151	Belongs to the GarS family
A3L01_00120	COG0047	phosphoribosylformylglycinamidine synthase activity
A3L01_00125	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A3L01_00135	COG0519	Catalyzes the synthesis of GMP from XMP
A3L01_00135	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A3L01_00140	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A3L01_00140	COG0519	Catalyzes the synthesis of GMP from XMP
A3L01_00210	COG2264	protein methyltransferase activity
A3L01_00310	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A3L01_00320	COG2234	aminopeptidase activity
A3L01_00385	COG0393	Putative heavy-metal-binding
A3L01_00405	COG2264	protein methyltransferase activity
A3L01_00420	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A3L01_00420	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A3L01_00425	COG0668	transmembrane transport
A3L01_00480	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A3L01_00485	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A3L01_00490	COG0552	protein localization to endoplasmic reticulum
A3L01_00495	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A3L01_00550	COG2252	PERMEase
A3L01_00565	COG1178	ABC-type Fe3 transport system permease component
A3L01_00590	COG0011	TIGRFAM Protein of
A3L01_00595	COG2078	PFAM AMMECR1 domain protein
A3L01_00605	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A3L01_00605	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A3L01_00610	COG0417	DNA replication proofreading
A3L01_00670	COG1185	polyribonucleotide nucleotidyltransferase activity
A3L01_00695	COG0252	asparaginase activity
A3L01_00705	COG1695	Transcriptional regulator
A3L01_00710	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A3L01_00710	COG2050	protein possibly involved in aromatic compounds catabolism
A3L01_00725	COG1335	isochorismatase
A3L01_00755	COG1013	pyruvate-flavodoxin oxidoreductase activity
A3L01_00800	COG1185	polyribonucleotide nucleotidyltransferase activity
A3L01_00805	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A3L01_00840	COG0517	IMP dehydrogenase activity
A3L01_00840	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A3L01_00845	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
A3L01_00850	COG0511	ligase activity, forming carbon-carbon bonds
A3L01_00850	COG5016	pyruvate
A3L01_00860	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A3L01_00870	COG1372	Participates in initiation and elongation during chromosome replication
A3L01_00870	COG0305	Participates in initiation and elongation during chromosome replication
A3L01_00895	COG0430	RNA-3'-phosphate cyclase activity
A3L01_00920	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
A3L01_00930	COG0543	2 iron, 2 sulfur cluster binding
A3L01_00965	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A3L01_00985	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A3L01_01030	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A3L01_01035	COG0088	Forms part of the polypeptide exit tunnel
A3L01_01040	COG0089	rRNA binding
A3L01_01045	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A3L01_01050	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A3L01_01060	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A3L01_01065	COG0255	Belongs to the universal ribosomal protein uL29 family
A3L01_01070	COG0023	Translation Initiation Factor
A3L01_01080	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A3L01_01085	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A3L01_01090	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A3L01_01100	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A3L01_01110	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A3L01_01115	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A3L01_01130	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A3L01_01135	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A3L01_01140	COG1841	ribosomal large subunit assembly
A3L01_01145	COG0200	Binds to the 23S rRNA
A3L01_01170	COG1102	Psort location Cytoplasmic, score
A3L01_01180	COG0300	oxidoreductase activity
A3L01_01185	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A3L01_01200	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A3L01_01205	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A3L01_01230	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A3L01_01235	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A3L01_01260	COG0052	Belongs to the universal ribosomal protein uS2 family
A3L01_01300	COG1522	sequence-specific DNA binding
A3L01_01310	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A3L01_01325	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A3L01_01345	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A3L01_01360	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
A3L01_01365	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A3L01_01370	COG1355	regulation of microtubule-based process
A3L01_01375	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A3L01_01390	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A3L01_01400	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A3L01_01405	COG2414	aldehyde ferredoxin oxidoreductase
A3L01_01410	COG1304	FMN binding
A3L01_01420	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A3L01_01425	COG0142	geranyltranstransferase activity
A3L01_01430	COG0477	Major facilitator Superfamily
A3L01_01435	COG0495	leucyl-tRNA aminoacylation
A3L01_01445	COG1574	metal-dependent hydrolase with the TIM-barrel fold
A3L01_01450	COG0006	proline dipeptidase activity
A3L01_01485	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
A3L01_01500	COG0864	Transcriptional regulator
A3L01_01515	COG1543	Belongs to the glycosyl hydrolase 57 family
A3L01_01520	COG0347	Belongs to the P(II) protein family
A3L01_01530	COG0733	neurotransmitter:sodium symporter activity
A3L01_01535	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A3L01_01550	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
A3L01_01555	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A3L01_01570	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A3L01_01580	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A3L01_01585	COG0534	Mate efflux family protein
A3L01_01590	COG0534	Mate efflux family protein
A3L01_01595	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A3L01_01595	COG0574	Belongs to the PEP-utilizing enzyme family
A3L01_01610	COG1404	Belongs to the peptidase S8 family
A3L01_01625	COG0446	pyridine nucleotide-disulphide oxidoreductase
A3L01_01640	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A3L01_01640	COG0731	radical SAM domain protein
A3L01_01660	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A3L01_01675	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
A3L01_01680	COG0409	Hydrogenase expression formation protein
A3L01_01685	COG0298	carbon dioxide binding
A3L01_01690	COG0746	molybdenum cofactor guanylyltransferase activity
A3L01_01705	COG0489	protein tyrosine kinase activity
A3L01_01745	COG4139	cobalamin transport
A3L01_01750	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A3L01_01765	COG1234	tRNA 3'-trailer cleavage
A3L01_01780	COG1994	Peptidase M50
A3L01_01785	COG2140	Oxalate decarboxylase
A3L01_01805	COG0662	Cupin 2, conserved barrel domain protein
A3L01_01805	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
A3L01_01835	COG0310	cobalt ion transport
A3L01_01850	COG1185	polyribonucleotide nucleotidyltransferase activity
A3L01_01895	COG0436	Aminotransferase
A3L01_01930	COG0049	tRNA binding
A3L01_01950	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A3L01_01955	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A3L01_01960	COG0085	RNA polymerase activity
A3L01_01995	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A3L01_02055	COG0584	glycerophosphoryl diester phosphodiesterase
A3L01_02065	COG2814	Major facilitator Superfamily
A3L01_02070	COG2271	Major facilitator Superfamily
A3L01_02075	COG1073	alpha beta
A3L01_02085	COG1131	(ABC) transporter
A3L01_02095	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A3L01_02110	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
A3L01_02115	COG0058	SHG alpha-glucan phosphorylase activity
A3L01_02120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A3L01_02145	COG0717	Belongs to the dCTP deaminase family
A3L01_02170	COG0081	regulation of translation
A3L01_02175	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A3L01_02240	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A3L01_02270	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
A3L01_02345	COG1110	DNA topoisomerase II activity
A3L01_02370	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
A3L01_02380	COG0546	phosphoglycolate phosphatase activity
A3L01_02395	COG1418	mRNA catabolic process
A3L01_02405	COG0017	Asparaginyl-tRNA synthetase
A3L01_02420	COG0585	pseudouridine synthase activity
A3L01_02435	COG1473	amidohydrolase
A3L01_02465	COG0504	CTP synthase activity
A3L01_02485	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A3L01_02510	COG0516	GMP reductase activity
A3L01_02510	COG0517	IMP dehydrogenase activity
A3L01_02520	COG0024	Methionine aminopeptidase
A3L01_02525	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A3L01_02530	COG1122	ATPase activity
A3L01_02570	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A3L01_02580	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A3L01_02625	COG0628	permease
A3L01_02630	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A3L01_02650	COG1131	(ABC) transporter
A3L01_02660	COG0556	nucleotide-excision repair
A3L01_02665	COG0101	tRNA pseudouridine synthase activity
A3L01_02670	COG0072	phenylalanine-tRNA ligase activity
A3L01_02675	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A3L01_02680	COG1063	alcohol dehydrogenase
A3L01_02685	COG2894	cell division
A3L01_02705	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A3L01_02710	COG0252	asparaginase activity
A3L01_02740	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A3L01_02790	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A3L01_02795	COG1085	galactose-1-phosphate uridylyltransferase
A3L01_02805	COG0038	chloride channel
A3L01_02815	COG0475	glutathione-regulated potassium exporter activity
A3L01_02825	COG0025	NhaP-type Na H and K H
A3L01_02835	COG0010	Belongs to the arginase family
A3L01_02880	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A3L01_02895	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
A3L01_02910	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
A3L01_02955	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A3L01_02955	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A3L01_02970	COG0359	binds to the 23S rRNA
A3L01_02970	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
A3L01_03020	COG0602	queuosine metabolic process
A3L01_03030	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A3L01_03065	COG1028	Short-chain dehydrogenase reductase Sdr
A3L01_03070	COG1881	PFAM PEBP family protein
A3L01_03125	COG1522	sequence-specific DNA binding
A3L01_03155	COG0649	NAD binding
A3L01_03160	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A3L01_03165	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A3L01_03175	COG0651	ATP synthesis coupled electron transport
A3L01_03180	COG0651	ATP synthesis coupled electron transport
A3L01_03185	COG1006	Multisubunit Na H antiporter MnhC subunit
A3L01_03190	COG2111	Na H antiporter
A3L01_03190	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A3L01_03200	COG1320	monovalent cation:proton antiporter activity
A3L01_03205	COG2212	antiporter activity
A3L01_03210	COG1863	multisubunit Na H antiporter MnhE subunit
A3L01_03220	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A3L01_03235	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A3L01_03255	COG0018	arginyl-trna synthetase
A3L01_03260	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A3L01_03350	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A3L01_03350	COG0301	tRNA thio-modification
A3L01_03360	COG1522	sequence-specific DNA binding
A3L01_03395	COG0396	ATPase activity
A3L01_03420	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
A3L01_03440	COG1131	(ABC) transporter
A3L01_03450	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A3L01_03490	COG0569	domain protein
A3L01_03510	COG1515	deoxyribonuclease V activity
A3L01_03520	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
A3L01_03530	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A3L01_03535	COG0501	Belongs to the peptidase M48B family
A3L01_03540	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A3L01_03545	COG0436	Aminotransferase
A3L01_03550	COG2192	nodulation
A3L01_03560	COG0442	prolyl-tRNA aminoacylation
A3L01_03565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A3L01_03575	COG0730	response to heat
A3L01_03585	COG0730	response to heat
A3L01_03615	COG0720	synthase
A3L01_03640	COG1013	pyruvate-flavodoxin oxidoreductase activity
A3L01_03645	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A3L01_03645	COG0674	pyruvate-flavodoxin oxidoreductase activity
A3L01_03655	COG1013	pyruvate-flavodoxin oxidoreductase activity
A3L01_03660	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A3L01_03660	COG0674	pyruvate-flavodoxin oxidoreductase activity
A3L01_03675	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A3L01_03685	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A3L01_03695	COG1744	ABC transporter substrate-binding protein PnrA-like
A3L01_03735	COG0215	cysteine-tRNA ligase activity
A3L01_03740	COG1047	Peptidyl-prolyl cis-trans
A3L01_03760	COG1505	serine-type exopeptidase activity
A3L01_03765	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A3L01_03770	COG1201	RNA secondary structure unwinding
A3L01_03790	COG0343	queuine tRNA-ribosyltransferase activity
A3L01_03810	COG0546	phosphoglycolate phosphatase activity
A3L01_03855	COG1363	Peptidase, m42
A3L01_03905	COG2814	Major facilitator Superfamily
A3L01_03915	COG2096	Adenosyltransferase
A3L01_03925	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A3L01_03930	COG1058	Belongs to the CinA family
A3L01_03930	COG1546	Belongs to the CinA family
A3L01_03940	COG1872	DUF167
A3L01_03955	COG2361	Protein of unknown function DUF86
A3L01_03960	COG0423	glycine-tRNA ligase activity
A3L01_03975	COG0534	Mate efflux family protein
A3L01_03995	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
A3L01_04010	COG0006	proline dipeptidase activity
A3L01_04025	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A3L01_04040	COG1918	ferrous iron import across plasma membrane
A3L01_04040	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A3L01_04050	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A3L01_04060	COG0163	prenyltransferase activity
A3L01_04075	COG0012	GTP binding
A3L01_04090	COG0598	Magnesium transport protein CorA
A3L01_04095	COG1794	racemase activity, acting on amino acids and derivatives
A3L01_04120	COG0312	modulator of DNA gyrase
A3L01_04155	COG0525	valine-tRNA ligase activity
A3L01_04160	COG2226	methyltransferase
A3L01_04165	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A3L01_04170	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
A3L01_04175	COG1573	uracil-dna glycosylase
A3L01_04185	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
A3L01_04190	COG2342	PFAM TM1410 hypothetical-related protein
A3L01_04195	COG0746	molybdenum cofactor guanylyltransferase activity
A3L01_04205	COG1492	cobalamin metabolic process
A3L01_04220	COG0521	Mo-molybdopterin cofactor biosynthetic process
A3L01_04225	COG0303	'Molybdopterin
A3L01_04250	COG1078	dGTPase activity
A3L01_04270	COG1899	peptidyl-lysine modification to peptidyl-hypusine
A3L01_04275	COG1028	Short-chain dehydrogenase reductase Sdr
A3L01_04280	COG1335	isochorismatase
A3L01_04285	COG0492	ferredoxin-NADP+ reductase activity
A3L01_04290	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A3L01_04300	COG0501	Belongs to the peptidase M48B family
A3L01_04310	COG0459	protein refolding
A3L01_04320	COG0515	serine threonine protein kinase
A3L01_04325	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A3L01_04335	COG0315	cyclic pyranopterin monophosphate synthase activity
A3L01_04375	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A3L01_04380	COG1216	Glycosyl transferase, family 2
A3L01_04410	COG1739	Uncharacterized protein family UPF0029
A3L01_04420	COG1111	helicase
A3L01_04420	COG1205	dead DEAH box helicase
A3L01_04430	COG1121	(ABC) transporter
A3L01_04480	COG2403	cyclic 2,3-diphosphoglycerate synthetase activity
A3L01_04505	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A3L01_04510	COG2414	aldehyde ferredoxin oxidoreductase
A3L01_04555	COG0051	transcription antitermination factor activity, RNA binding
A3L01_04560	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A3L01_04570	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A3L01_04585	COG1078	dGTPase activity
A3L01_04590	COG1469	GTP cyclohydrolase I activity
A3L01_04615	COG2205	protein histidine kinase activity
A3L01_04635	COG1121	(ABC) transporter
A3L01_04645	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A3L01_04665	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A3L01_04680	COG2226	methyltransferase
A3L01_04685	COG0011	TIGRFAM Protein of
A3L01_04700	COG0563	adenylate kinase activity
A3L01_04715	COG0531	amino acid
A3L01_04730	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A3L01_04770	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A3L01_04775	COG1993	acr, cog1993
A3L01_04785	COG0668	transmembrane transport
A3L01_04795	COG1794	racemase activity, acting on amino acids and derivatives
A3L01_04810	COG0312	modulator of DNA gyrase
A3L01_04820	COG2814	Major facilitator Superfamily
A3L01_04825	COG0477	Major facilitator Superfamily
A3L01_04855	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A3L01_04890	COG0243	molybdopterin cofactor binding
A3L01_04895	COG0450	alkyl hydroperoxide reductase
A3L01_04925	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A3L01_04930	COG2217	Heavy metal translocating P-type atpase
A3L01_04940	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A3L01_04975	COG1592	Rubrerythrin
A3L01_04980	COG1773	rubredoxin
A3L01_04985	COG2033	superoxide reductase activity
A3L01_05030	COG0735	belongs to the Fur family
A3L01_05045	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A3L01_05085	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A3L01_05095	COG0131	Imidazoleglycerol-phosphate dehydratase
A3L01_05100	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A3L01_05105	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A3L01_05110	COG0107	imidazoleglycerol-phosphate synthase activity
A3L01_05115	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A3L01_05115	COG0140	phosphoribosyl-ATP diphosphatase activity
A3L01_05120	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A3L01_05140	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A3L01_05150	COG1301	dicarboxylic acid transport
A3L01_05155	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A3L01_05155	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A3L01_05160	COG1830	Aldolase
A3L01_05170	COG1966	Carbon starvation protein
A3L01_05180	COG0003	Pfam Anion-transporting ATPase
A3L01_05205	COG2267	carboxylic ester hydrolase activity
A3L01_05215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A3L01_05240	COG0489	protein tyrosine kinase activity
A3L01_05270	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A3L01_05320	COG1342	Belongs to the UPF0251 family
A3L01_05325	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A3L01_05350	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A3L01_05365	COG1201	RNA secondary structure unwinding
A3L01_05370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A3L01_05385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A3L01_05400	COG0084	hydrolase, TatD family'
A3L01_05430	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A3L01_05445	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A3L01_05455	COG0105	UTP biosynthetic process
A3L01_05505	COG0402	S-adenosylhomocysteine deaminase activity
A3L01_05565	COG0017	Asparaginyl-tRNA synthetase
A3L01_05605	COG1444	tRNA N-acetyltransferase activity
A3L01_05610	COG4946	Tricorn protease homolog
A3L01_05610	COG1506	peptidase
A3L01_05610	COG0823	Involved in the tonB-independent uptake of proteins
A3L01_05630	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
A3L01_05645	COG1268	BioY protein
A3L01_05650	COG1122	ATPase activity
A3L01_05655	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A3L01_05680	COG1522	sequence-specific DNA binding
A3L01_05700	COG1178	ABC-type Fe3 transport system permease component
A3L01_05705	COG3842	ATPase activity
A3L01_05770	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A3L01_05805	COG0045	succinate-CoA ligase (ADP-forming) activity
A3L01_05805	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A3L01_05805	COG1042	CoA-binding domain protein
A3L01_05835	COG0301	tRNA thio-modification
A3L01_05855	COG0301	tRNA thio-modification
A3L01_05890	COG1215	transferase activity, transferring glycosyl groups
A3L01_05895	COG1489	DNA binding
A3L01_05915	COG1199	ATP-dependent helicase activity
A3L01_05950	COG0483	inositol monophosphate 1-phosphatase activity
A3L01_05960	COG1454	alcohol dehydrogenase
A3L01_05970	COG1984	allophanate hydrolase subunit 2
A3L01_05975	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A3L01_05980	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A3L01_06005	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A3L01_06020	COG0330	HflC and HflK could
A3L01_06025	COG2894	cell division
A3L01_06040	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A3L01_06055	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
A3L01_06070	COG0513	Belongs to the DEAD box helicase family
A3L01_06095	COG1196	nuclear chromosome segregation
A3L01_06115	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A3L01_06115	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A3L01_06160	COG2894	cell division
A3L01_06170	COG0367	asparagine synthase
A3L01_06185	COG0009	L-threonylcarbamoyladenylate synthase
A3L01_06205	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A3L01_06210	COG0303	'Molybdopterin
A3L01_06220	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A3L01_06235	COG0045	succinate-CoA ligase (ADP-forming) activity
A3L01_06235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A3L01_06235	COG1042	CoA-binding domain protein
A3L01_06280	COG0482	sulfurtransferase activity
A3L01_06325	COG1793	dna ligase
A3L01_06325	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A3L01_06330	COG0071	Belongs to the small heat shock protein (HSP20) family
A3L01_06370	COG0733	neurotransmitter:sodium symporter activity
A3L01_06380	COG0747	negative chemotaxis
A3L01_06385	COG0601	transmembrane transport
A3L01_06390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A3L01_06395	COG0444	Belongs to the ABC transporter superfamily
A3L01_06400	COG4608	Belongs to the ABC transporter superfamily
A3L01_06410	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A3L01_06420	COG0778	Nitroreductase
A3L01_06430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A3L01_06430	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A3L01_06480	COG1056	cytidyltransferase-related domain
A3L01_06480	COG1051	belongs to the nudix hydrolase family
A3L01_06530	COG0560	Phosphoserine phosphatase
A3L01_06535	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A3L01_06560	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
A3L01_06565	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A3L01_06575	COG3842	ATPase activity
A3L01_06580	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
A3L01_06585	COG0725	ABC transporter, periplasmic molybdate-binding protein
A3L01_06605	COG1160	GTP binding
A3L01_06610	COG0432	Pfam Uncharacterised protein family UPF0047
A3L01_06640	COG1832	CoA-binding protein
A3L01_06670	COG2379	hydroxypyruvate reductase
A3L01_06680	COG3842	ATPase activity
A3L01_06705	COG0673	inositol 2-dehydrogenase activity
A3L01_06710	COG0463	Glycosyl transferase, family 2
A3L01_06725	COG0395	ABC-type sugar transport system, permease component
A3L01_06740	COG0438	transferase activity, transferring glycosyl groups
A3L01_06750	COG3842	ATPase activity
A3L01_06790	COG1850	ribulose-bisphosphate carboxylase activity
A3L01_06835	COG1131	(ABC) transporter
A3L01_06850	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A3L01_06850	COG1213	nucleotidyl transferase
A3L01_06855	COG3842	ATPase activity
A3L01_06860	COG0395	ABC-type sugar transport system, permease component
A3L01_06885	COG0284	orotidine-5'-phosphate decarboxylase activity
A3L01_06895	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A3L01_06895	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A3L01_06905	COG1192	Involved in chromosome partitioning
A3L01_06910	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A3L01_06915	COG0864	Transcriptional regulator
A3L01_06930	COG2119	membrane
A3L01_06965	COG1476	TRANSCRIPTIONal
A3L01_06975	COG1131	(ABC) transporter
A3L01_07010	COG4608	Belongs to the ABC transporter superfamily
A3L01_07015	COG0444	Belongs to the ABC transporter superfamily
A3L01_07025	COG0601	transmembrane transport
A3L01_07030	COG0747	negative chemotaxis
A3L01_07055	COG0543	2 iron, 2 sulfur cluster binding
A3L01_07060	COG0493	'glutamate synthase
A3L01_07060	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A3L01_07075	COG0509	glycine decarboxylation via glycine cleavage system
A3L01_07080	COG1863	multisubunit Na H antiporter MnhE subunit
A3L01_07085	COG2212	antiporter activity
A3L01_07115	COG0651	ATP synthesis coupled electron transport
A3L01_07140	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A3L01_07170	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A3L01_07195	COG0123	including yeast histone deacetylase and acetoin utilization protein
A3L01_07240	COG0183	Belongs to the thiolase family
A3L01_07245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A3L01_07270	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A3L01_07275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A3L01_07280	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A3L01_07290	COG1765	OsmC-like protein
A3L01_07295	COG2095	MarC family integral membrane protein
A3L01_07315	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
A3L01_07330	COG0693	protein deglycase activity
A3L01_07335	COG1522	sequence-specific DNA binding
A3L01_07340	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A3L01_07365	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A3L01_07380	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A3L01_07390	COG2814	Major facilitator Superfamily
A3L01_07405	COG2723	6-phospho-beta-galactosidase activity
A3L01_07425	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A3L01_07430	COG0446	pyridine nucleotide-disulphide oxidoreductase
A3L01_07450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A3L01_07485	COG0167	dihydroorotate dehydrogenase activity
A3L01_07490	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A3L01_07510	COG2414	aldehyde ferredoxin oxidoreductase
A3L01_07515	COG1404	Belongs to the peptidase S8 family
A3L01_07535	COG2151	metal-sulfur cluster biosynthetic enzyme
A3L01_07545	COG1141	Ferredoxin
A3L01_07555	COG1028	Short-chain dehydrogenase reductase Sdr
A3L01_07575	COG0493	'glutamate synthase
A3L01_07580	COG0543	2 iron, 2 sulfur cluster binding
A3L01_07615	COG0501	Belongs to the peptidase M48B family
A3L01_07620	COG2131	deaminase
A3L01_07630	COG0546	phosphoglycolate phosphatase activity
A3L01_07635	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A3L01_07645	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A3L01_07650	COG2271	Major facilitator Superfamily
A3L01_07675	COG1446	asparaginase
A3L01_07685	COG2814	Major facilitator Superfamily
A3L01_07695	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
A3L01_07745	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A3L01_07780	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A3L01_07800	COG2255	four-way junction helicase activity
A3L01_07805	COG2255	four-way junction helicase activity
A3L01_07810	COG0156	8-amino-7-oxononanoate synthase activity
A3L01_07825	COG1214	PFAM Peptidase M22, glycoprotease
A3L01_07825	COG0456	acetyltransferase
A3L01_07830	COG0433	COG0433 Predicted ATPase
A3L01_07840	COG0419	ATPase involved in DNA repair
A3L01_07840	COG0419	ATPase involved in DNA repair
A3L01_07860	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A3L01_07880	COG2078	PFAM AMMECR1 domain protein
A3L01_07880	COG3885	ferrous iron binding
A3L01_07885	COG1373	ATPase (AAA superfamily
A3L01_07910	COG0432	Pfam Uncharacterised protein family UPF0047
A3L01_07925	COG0540	Belongs to the ATCase OTCase family
A3L01_07930	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
A3L01_07965	COG1988	membrane-bound metal-dependent
A3L01_07970	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A3L01_07995	COG0434	BtpA family
A3L01_08010	COG0714	Associated with various cellular activities
A3L01_08040	COG0312	modulator of DNA gyrase
A3L01_08045	COG0312	modulator of DNA gyrase
A3L01_08050	COG1846	Transcriptional regulator
A3L01_08065	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A3L01_08105	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A3L01_08110	COG1373	ATPase (AAA superfamily
A3L01_08115	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A3L01_08125	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A3L01_08170	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A3L01_08175	COG0306	phosphate transporter
A3L01_08190	COG0674	pyruvate-flavodoxin oxidoreductase activity
A3L01_08195	COG1013	pyruvate-flavodoxin oxidoreductase activity
A3L01_08205	COG0674	pyruvate-flavodoxin oxidoreductase activity
A3L01_08210	COG1013	pyruvate-flavodoxin oxidoreductase activity
A3L01_08220	COG0437	4 iron, 4 sulfur cluster binding
A3L01_08225	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A3L01_08225	COG0493	'glutamate synthase
A3L01_08230	COG1141	Ferredoxin
A3L01_08235	COG1151	hydroxylamine reductase activity
A3L01_08240	COG0437	4 iron, 4 sulfur cluster binding
A3L01_08250	COG0489	protein tyrosine kinase activity
A3L01_08285	COG1254	Belongs to the acylphosphatase family
A3L01_08290	COG1324	tolerance protein
A3L01_08295	COG1628	Protein of unknown function DUF99
A3L01_08305	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A3L01_08325	COG1980	fructose-bisphosphate aldolase activity
A3L01_08345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A3L01_08360	COG1233	COG1233 Phytoene dehydrogenase and related
A3L01_08400	COG2226	methyltransferase
A3L01_08410	COG1522	sequence-specific DNA binding
A3L01_08425	COG2894	cell division
A3L01_08450	COG1757	Na H antiporter
A3L01_08455	COG1573	uracil-dna glycosylase
A3L01_08465	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A3L01_08480	COG1380	Effector of murein hydrolase LrgA
A3L01_08485	COG1346	cytolysis
A3L01_08505	COG0235	Class ii aldolase
A3L01_08515	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
A3L01_08555	COG0095	Lipoate-protein ligase
A3L01_08580	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A3L01_08605	COG0823	Involved in the tonB-independent uptake of proteins
A3L01_08605	COG1506	peptidase
A3L01_08605	COG4946	Tricorn protease homolog
A3L01_08630	COG0306	phosphate transporter
A3L01_08660	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A3L01_08665	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A3L01_08670	COG1863	multisubunit Na H antiporter MnhE subunit
A3L01_08675	COG2212	antiporter activity
A3L01_08680	COG1320	monovalent cation:proton antiporter activity
A3L01_08705	COG0651	ATP synthesis coupled electron transport
A3L01_08715	COG3260	NADH ubiquinone oxidoreductase 20
A3L01_08720	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A3L01_08730	COG0650	Formate hydrogenlyase subunit 4
A3L01_08735	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A3L01_08745	COG2212	antiporter activity
A3L01_08765	COG2111	Na H antiporter
A3L01_08770	COG1006	Multisubunit Na H antiporter MnhC subunit
A3L01_08775	COG0651	ATP synthesis coupled electron transport
A3L01_08785	COG3260	NADH ubiquinone oxidoreductase 20
A3L01_08790	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A3L01_08800	COG0650	Formate hydrogenlyase subunit 4
A3L01_08845	COG0492	ferredoxin-NADP+ reductase activity
A3L01_08850	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A3L01_08880	COG0148	phosphopyruvate hydratase activity
A3L01_08895	COG1522	sequence-specific DNA binding
A3L01_08900	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A3L01_08920	COG0314	molybdopterin synthase activity
A3L01_08930	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A3L01_08970	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A3L01_08970	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
A3L01_08985	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A3L01_08995	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A3L01_09110	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A3L01_09120	COG0402	S-adenosylhomocysteine deaminase activity
A3L01_09130	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A3L01_09130	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A3L01_09145	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A3L01_09145	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A3L01_09165	COG0640	Transcriptional regulator
A3L01_09175	COG0640	Transcriptional regulator
A3L01_09200	COG0179	Fumarylacetoacetate (FAA) hydrolase
A3L01_09225	COG0116	Belongs to the methyltransferase superfamily
A3L01_09225	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A3L01_09230	COG1160	GTP binding
A3L01_09265	COG1047	Peptidyl-prolyl cis-trans
A3L01_09285	COG0714	Associated with various cellular activities
A3L01_09305	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
A3L01_09320	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A3L01_09325	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
A3L01_09360	COG0037	tRNA processing
A3L01_09370	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A3L01_09375	COG0463	Glycosyl transferase, family 2
A3L01_09375	COG1216	Glycosyl transferase, family 2
A3L01_09380	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A3L01_09385	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A3L01_09400	COG0297	glycogen (starch) synthase activity
A3L01_09415	COG0730	response to heat
A3L01_09435	COG2046	Belongs to the sulfate adenylyltransferase family
A3L01_09465	COG4166	transmembrane transport
A3L01_09470	COG0601	transmembrane transport
A3L01_09480	COG0444	Belongs to the ABC transporter superfamily
A3L01_09485	COG4608	Belongs to the ABC transporter superfamily
A3L01_09490	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A3L01_09500	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A3L01_09540	COG1449	Belongs to the glycosyl hydrolase 57 family
A3L01_09550	COG0037	tRNA processing
A3L01_09565	COG0492	ferredoxin-NADP+ reductase activity
A3L01_09570	COG2239	Acts as a magnesium transporter
A3L01_09575	COG0475	glutathione-regulated potassium exporter activity
A3L01_09580	COG0475	glutathione-regulated potassium exporter activity
A3L01_09675	COG1115	amino acid carrier protein
A3L01_09720	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A3L01_09730	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A3L01_09785	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A3L01_09795	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
A3L01_09810	COG0569	domain protein
A3L01_09820	COG1269	ATP hydrolysis coupled proton transport
A3L01_09830	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
A3L01_09840	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
A3L01_09845	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
A3L01_09855	COG1394	ATPase activity, coupled to movement of substances
A3L01_09860	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A3L01_09885	COG1606	tRNA processing
A3L01_09905	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A3L01_09915	COG0601	transmembrane transport
A3L01_09920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A3L01_09925	COG0444	Belongs to the ABC transporter superfamily
A3L01_09930	COG4608	Belongs to the ABC transporter superfamily
A3L01_09950	COG0174	glutamine synthetase
A3L01_09990	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A3L01_10010	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A3L01_10035	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A3L01_10040	COG1234	tRNA 3'-trailer cleavage
A3L01_10050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A3L01_10060	COG3842	ATPase activity
A3L01_10070	COG3833	ABC-type maltose transport systems, permease component
A3L01_10075	COG1175	transmembrane transport
A3L01_10090	COG1378	Sugar-specific transcriptional regulator TrmB
A3L01_10095	COG0297	glycogen (starch) synthase activity
A3L01_10145	COG1373	ATPase (AAA superfamily
A3L01_10150	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
A3L01_10155	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
A3L01_10160	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A3L01_10170	COG0647	UMP catabolic process
A3L01_10205	COG0714	Associated with various cellular activities
A3L01_10220	COG0463	Glycosyl transferase, family 2
A3L01_10245	COG1404	Belongs to the peptidase S8 family
A3L01_10255	COG3119	arylsulfatase activity
A3L01_10265	COG1091	dTDP-4-dehydrorhamnose reductase activity