locus-tag	class	description
A3L04_00005	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
A3L04_00010	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
A3L04_00020	ENOG4105CS2	ec 3.2.1.21
A3L04_00055	ENOG4105CHR	reductase
A3L04_00065	ENOG4108NGU	Transcriptional regulator
A3L04_00070	ENOG4105CJ1	ABC, transporter
A3L04_00080	ENOG4107QWP	ABC-2 type transporter
A3L04_00095	ENOG41084T3	4fe-4S ferredoxin iron-sulfur binding domain-containing protein
A3L04_00105	ENOG4105CDJ	oxidoreductase FAD NAD(P)-binding domain protein
A3L04_00110	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
A3L04_00130	ENOG4106J7S	Glycosyl transferase, family 2
A3L04_00150	ENOG4105EAC	phosphoserine phosphatase
A3L04_00155	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
A3L04_00230	ENOG4105CZV	ABC transporter
A3L04_00235	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
A3L04_00240	ENOG4105ECY	inositol monophosphatase
A3L04_00250	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
A3L04_00290	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
A3L04_00305	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
A3L04_00340	ENOG4105CJ1	ABC, transporter
A3L04_00355	ENOG4107RGW	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A3L04_00375	ENOG4105DHP	deoxycytidine triphosphate deaminase
A3L04_00395	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
A3L04_00400	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
A3L04_00415	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
A3L04_00460	ENOG4105NBF	ammecr1 domain protein
A3L04_00465	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
A3L04_00485	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
A3L04_00495	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
A3L04_00505	ENOG4108IYU	L-aspartate oxidase
A3L04_00510	ENOG4108MYP	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
A3L04_00535	ENOG4108IJ9	(ABC) transporter
A3L04_00540	ENOG4105E2Z	phosphate ABC transporter (Permease
A3L04_00575	ENOG4105DB3	bacteriochlorophyll chlorophyll a synthase
A3L04_00585	ENOG4107TSN	permease
A3L04_00590	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
A3L04_00620	ENOG4105CPC	Aldo Keto reductase
A3L04_00635	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
A3L04_00660	ENOG4105E3H	phosphoglycerate mutase
A3L04_00705	ENOG4105IIU	Aminopeptidase
A3L04_00725	ENOG4108R6K	riboflavin synthase, subunit alpha
A3L04_00730	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
A3L04_00780	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
A3L04_00785	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
A3L04_00810	ENOG4105D06	uba thif-type nad fad binding protein
A3L04_00820	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
A3L04_00845	ENOG4108ZPQ	MazG nucleotide pyrophosphohydrolase
A3L04_00875	ENOG4105HDK	L-asparaginase
A3L04_00890	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
A3L04_00895	ENOG4108UUC	Protein of unknown function DUF99
A3L04_00935	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
A3L04_00950	ENOG41066FR	extracellular solute-binding protein
A3L04_00960	ENOG4105E0C	molybdate abc transporter
A3L04_00965	ENOG41090JH	(ATPase)-like protein
A3L04_00975	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
A3L04_00980	ENOG4105VKD	bioY protein
A3L04_01000	ENOG410695F	Crispr-associated protein, Csm1 family
A3L04_01010	ENOG4108W8W	CRISPR-associated RAMP protein, Csm3 family
A3L04_01020	ENOG4105G15	CRISPR-associated RAMP protein, Csm5 family
A3L04_01050	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
A3L04_01065	ENOG4105DTT	CRISPR-associated helicase, cas3
A3L04_01080	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
A3L04_01100	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
A3L04_01125	ENOG4105M7V	2'-5' rna ligase
A3L04_01135	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
A3L04_01175	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
A3L04_01195	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
A3L04_01220	ENOG41061GT	Aldolase
A3L04_01250	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
A3L04_01260	ENOG4105C2X	Arabinose 5-phosphate isomerase
A3L04_01265	ENOG4105C11	sulfate adenylyltransferase), subunit 2
A3L04_01275	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
A3L04_01285	ENOG4108ZVT	methylmalonyl-coA epimerase
A3L04_01295	ENOG4105D5P	Methylmalonyl-coA mutase
A3L04_01345	ENOG4105EHU	Circadian clock protein KaiC
A3L04_01350	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
A3L04_01380	ENOG4107PBV	potassium channel
A3L04_01395	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
A3L04_01410	ENOG4108JJB	ABC transporter
A3L04_01415	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
A3L04_01430	ENOG4105CYV	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity)
A3L04_01455	ENOG4105CB1	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
A3L04_01475	ENOG4105E8R	UPF0173 metal-dependent hydrolase
A3L04_01480	ENOG4105EHU	Circadian clock protein KaiC
A3L04_01510	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
A3L04_01555	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
A3L04_01560	ENOG4105C6E	dna polymerase iii
A3L04_01570	ENOG4108JU3	Alkyl hydroperoxide reductase
A3L04_01585	ENOG4105C4K	Nad synthetase
A3L04_01595	ENOG4108ZAF	Molybdopterin
A3L04_01605	ENOG4105EHU	Circadian clock protein KaiC
A3L04_01610	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
A3L04_01630	ENOG4108S8N	class II Aldolase
A3L04_01655	ENOG410825M	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
A3L04_01660	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
A3L04_01670	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
A3L04_01695	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
A3L04_01700	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
A3L04_01710	ENOG4108NGU	Transcriptional regulator
A3L04_01720	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
A3L04_01725	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
A3L04_01780	ENOG4105DK7	lysyl-tRNA synthetase
A3L04_01790	ENOG4108D32	Methyltransferase
A3L04_01820	ENOG4105D44	asparaginase
A3L04_01845	ENOG4105CHR	reductase
A3L04_01865	ENOG4105C8V	SAICAR synthetase
A3L04_01885	ENOG4105C5S	asparaginyl-tRNA synthetase
A3L04_01900	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
A3L04_01915	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
A3L04_01950	ENOG4105DZP	Membrane-associated zinc metalloprotease
A3L04_01975	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
A3L04_01980	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
A3L04_01985	ENOG4105C3D	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
A3L04_02010	ENOG4105K4G	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
A3L04_02025	ENOG4108JIQ	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity)
A3L04_02030	ENOG4108JIP	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity)
A3L04_02035	ENOG4105M56	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
A3L04_02045	ENOG4107SDU	Methyl-accepting chemotaxis
A3L04_02050	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
A3L04_02055	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
A3L04_02065	ENOG4105DF0	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity)
A3L04_02070	ENOG4105CD3	dihydroorotase
A3L04_02080	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
A3L04_02085	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
A3L04_02090	ENOG4105C3U	ABC transporter
A3L04_02095	ENOG4108JQ7	(ABC) transporter
A3L04_02105	ENOG4108Y83	glucose-6-phosphate isomerase
A3L04_02115	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
A3L04_02125	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
A3L04_02130	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
A3L04_02135	ENOG4105VG1	fes assembly suf system protein
A3L04_02150	ENOG4105CH7	arginosuccinase
A3L04_02155	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
A3L04_02180	ENOG4105CQ2	DNA polymerase
A3L04_02185	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
A3L04_02195	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
A3L04_02200	ENOG4108Z03	MAF-like protein
A3L04_02215	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
A3L04_02220	ENOG4108VA3	3-hexulose-6-phosphate synthase
A3L04_02230	ENOG4105U0R	haloacid dehalogenase-like hydrolase
A3L04_02260	ENOG41082SX	arsR family transcriptional regulator
A3L04_02285	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
A3L04_02290	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
A3L04_02325	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
A3L04_02330	ENOG4108VVK	transcriptional Regulator, AsnC
A3L04_02335	ENOG4105DR4	Methyltransferase
A3L04_02345	ENOG4108J9M	Transporter
A3L04_02375	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
A3L04_02380	ENOG4105F0N	pyrophosphate phospho-hydrolase
A3L04_02405	ENOG4105EYF	MMPL domain protein
A3L04_02425	ENOG4105CUT	histidyl-tRNA synthetase
A3L04_02430	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
A3L04_02455	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
A3L04_02475	ENOG4105C6W	4-alpha-glucanotransferase (EC 2.4.1.25)
A3L04_02490	ENOG4107R8N	Glycosyl transferase, family 2
A3L04_02500	ENOG4107R56	PP-loop domain protein
A3L04_02505	ENOG4107RWR	Sodium hydrogen exchanger
A3L04_02510	ENOG4105DZ0	fad dependent oxidoreductase
A3L04_02525	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
A3L04_02535	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
A3L04_02560	ENOG4105CBC	glutamate synthase
A3L04_02565	ENOG4105EYU	Glutamine amido-transferase
A3L04_02570	ENOG4105BZN	citrate synthase
A3L04_02575	ENOG4108HMX	isocitrate dehydrogenase (NADP)
A3L04_02580	ENOG4107QM5	aconitate hydratase
A3L04_02585	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
A3L04_02590	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
A3L04_02600	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
A3L04_02605	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
A3L04_02650	ENOG4105CKK	Glycosyl transferase, family 2
A3L04_02670	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
A3L04_02675	ENOG4105CAT	Cytidine monophosphate kinase
A3L04_02695	ENOG4105E2K	Glycosyl transferase (Group 1
A3L04_02700	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
A3L04_02780	ENOG4108RBV	CRISPR-associated protein, Csx3 family
A3L04_02830	ENOG4108V3W	Chemotaxis protein, CheW
A3L04_02835	ENOG4105C8Q	Methyl-accepting chemotaxis
A3L04_02840	ENOG4105BZU	Histidine kinase
A3L04_02845	ENOG4107YTP	response regulator receiver protein
A3L04_02850	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
A3L04_02855	ENOG4105CBS	Chea signal transduction histidine kinase
A3L04_02860	ENOG4107PHP	CheC --inhibitor of MCP methylation
A3L04_02870	ENOG4108Z4W	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity)
A3L04_02875	ENOG4105C8Q	Methyl-accepting chemotaxis
A3L04_02895	ENOG4105D1Z	hydroxypyruvate reductase
A3L04_02905	ENOG4105FJR	Lmbe family
A3L04_02920	ENOG4105CS2	ec 3.2.1.21
A3L04_02930	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
A3L04_02940	ENOG4108JQ7	(ABC) transporter
A3L04_02945	ENOG4108JQ7	(ABC) transporter
A3L04_02950	ENOG4106R7G	Glycoside hydrolase family 5
A3L04_02965	ENOG4105EHG	Permease protein
A3L04_02970	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
A3L04_03020	ENOG4105C8Q	Methyl-accepting chemotaxis
A3L04_03030	ENOG4105CJ1	ABC, transporter
A3L04_03045	ENOG4108RVA	ribokinase
A3L04_03050	ENOG4107Y70	Heat shock protein
A3L04_03055	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
A3L04_03070	ENOG4108T9Q	UPF0278 protein
A3L04_03085	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
A3L04_03120	ENOG4108K3F	N(2),N(2)-dimethylguanosine tRNA methyltransferase
A3L04_03135	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
A3L04_03145	ENOG4105DZH	s-adenosylmethionine synthetase (EC 2.5.1.6)
A3L04_03155	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
A3L04_03165	ENOG4105CN9	Peptidase m42 family protein
A3L04_03180	ENOG4105C6T	cysteine synthase
A3L04_03185	ENOG4108JJB	ABC transporter
A3L04_03190	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
A3L04_03200	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
A3L04_03210	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
A3L04_03215	ENOG4105BZ8	glutamate synthase
A3L04_03225	ENOG4105UQX	Mate efflux family protein
A3L04_03240	ENOG4108R96	Methyltransferase, YaeB family
A3L04_03245	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
A3L04_03260	ENOG41067MG	lrgb family
A3L04_03270	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
A3L04_03305	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
A3L04_03315	ENOG4105CD5	CoA-binding domain protein
A3L04_03340	ENOG4105DZA	Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity)
A3L04_03355	ENOG4105DCI	Phosphohydrolase
A3L04_03365	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
A3L04_03375	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
A3L04_03385	ENOG4105KZR	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
A3L04_03390	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A3L04_03395	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
A3L04_03405	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
A3L04_03410	ENOG41082SA	50s ribosomal protein l29
A3L04_03430	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
A3L04_03445	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A3L04_03455	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
A3L04_03460	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
A3L04_03475	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
A3L04_03480	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
A3L04_03490	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
A3L04_03510	ENOG41080HI	glycine oxidase
A3L04_03560	ENOG4107XGZ	Hydrolase
A3L04_03565	ENOG4108IAJ	Nad-dependent epimerase dehydratase
A3L04_03570	ENOG4105CD5	CoA-binding domain protein
A3L04_03620	ENOG4105D0M	Protease HtpX homolog
A3L04_03640	ENOG4105C49	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity)
A3L04_03645	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
A3L04_03655	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
A3L04_03670	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
A3L04_03675	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
A3L04_03680	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
A3L04_03685	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
A3L04_03690	ENOG4105CIH	Imidazole acetol-phosphate transaminase
A3L04_03725	ENOG410631K	Membrane
A3L04_03735	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
A3L04_03765	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
A3L04_03770	ENOG4108JZA	Homocitrate synthase
A3L04_03775	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
A3L04_03780	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
A3L04_03785	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
A3L04_03795	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
A3L04_03800	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
A3L04_03805	ENOG4105CAS	nag kinase
A3L04_03810	ENOG4105C8Y	Acetylornithine aminotransferase
A3L04_03815	ENOG4108KB0	deacetylase
A3L04_03825	ENOG4108HHA	Transketolase
A3L04_03835	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
A3L04_03840	ENOG4105D49	3-dehydroquinate synthase
A3L04_03845	ENOG4105FF2	Type I DHQase
A3L04_03850	ENOG4105E2X	shikimate dehydrogenase
A3L04_03855	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
A3L04_03860	ENOG4105DIH	basic membrane
A3L04_03865	ENOG4108JQ9	ABC transporter
A3L04_03880	ENOG4105CPQ	Dehydrogenase
A3L04_03900	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
A3L04_03905	ENOG4105EHE	chorismate mutase- prephenate dehydrogenase
A3L04_03910	ENOG4105CHM	Aminotransferase
A3L04_03920	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
A3L04_03925	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
A3L04_03930	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
A3L04_03935	ENOG4105DDQ	anthranilate synthase
A3L04_03940	ENOG4105CRQ	synthase (Component I)
A3L04_03945	ENOG4107QYG	anthranilate phosphoribosyltransferase
A3L04_03960	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
A3L04_03980	ENOG4105EM7	Selenocysteine-specific translation elongation factor
A3L04_03990	ENOG4108Z0Z	intracellular protease Pfpi family
A3L04_04010	ENOG4105EPH	radical SAM domain protein
A3L04_04035	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
A3L04_04055	ENOG4108RYR	transcriptional regulator AsnC family
A3L04_04080	ENOG4105CX6	glutaminyL-tRNA synthetase
A3L04_04090	ENOG4105F4P	)-transporter
A3L04_04115	ENOG4106DSS	Tartrate dehydratase subunit alpha
A3L04_04125	ENOG4108IXY	short-chain dehydrogenase reductase
A3L04_04140	ENOG4105K8R	UPF0145 protein
A3L04_04160	ENOG4108KN7	Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity)
A3L04_04170	ENOG4107R56	PP-loop domain protein
A3L04_04200	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A3L04_04205	ENOG4107WCI	zn-dependent hydrolase of the beta-lactamase fold-like protein
A3L04_04210	ENOG41086YC	UPF0235 protein
A3L04_04215	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
A3L04_04225	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
A3L04_04230	ENOG4105DQU	oxidoreductase, subunit beta
A3L04_04240	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
A3L04_04245	ENOG4105DQU	oxidoreductase, subunit beta
A3L04_04255	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
A3L04_04275	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
A3L04_04280	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
A3L04_04300	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
A3L04_04310	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
A3L04_04330	ENOG4107Y49	methyltransferase
A3L04_04340	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A3L04_04345	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
A3L04_04350	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
A3L04_04370	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
A3L04_04375	ENOG4108UJD	30S ribosomal protein S9
A3L04_04395	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
A3L04_04400	ENOG4105CE9	30S ribosomal protein S2
A3L04_04405	ENOG4108IYI	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
A3L04_04410	ENOG41074MP	UPF0103 Mediator of ErbB2-driven cell motility-containing protein
A3L04_04415	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
A3L04_04420	ENOG4107RRU	Involved in both the arginine and lysine biosynthetic pathways (By similarity)
A3L04_04455	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
A3L04_04475	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
A3L04_04480	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
A3L04_04500	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
A3L04_04505	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
A3L04_04540	ENOG4107QMS	site-determining protein
A3L04_04550	ENOG4105CMW	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)
A3L04_04555	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
A3L04_04570	ENOG4107RWR	Sodium hydrogen exchanger
A3L04_04575	ENOG4105D82	Glutamate dehydrogenase
A3L04_04580	ENOG4105F7P	transcriptional regulator AsnC family
A3L04_04590	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
A3L04_04595	ENOG4108UK2	deaminase
A3L04_04600	ENOG4105D0M	Protease HtpX homolog
A3L04_04615	ENOG4105CKK	Glycosyl transferase, family 2
A3L04_04625	ENOG4108JEB	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
A3L04_04670	ENOG4105IPI	Membrane
A3L04_04680	ENOG4105D07	Signal peptide peptidase, SppA
A3L04_04700	ENOG41065SU	Two-component system sensor kinase
A3L04_04750	ENOG4105KPK	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
A3L04_04765	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
A3L04_04770	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
A3L04_04800	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
A3L04_04810	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
A3L04_04830	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
A3L04_04845	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
A3L04_04855	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
A3L04_04900	ENOG4105E7Q	Cob(II)yrinic acid a,c-diamide reductase
A3L04_04930	ENOG4105VZ8	Transcriptional regulator
A3L04_04940	ENOG4105CJ1	ABC, transporter
A3L04_04955	ENOG4105CKX	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP
A3L04_04965	ENOG4105CN9	Peptidase m42 family protein
A3L04_04995	ENOG4108VVK	transcriptional Regulator, AsnC
A3L04_05015	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
A3L04_05020	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
A3L04_05030	ENOG4105D1H	recombination factor protein RarA
A3L04_05035	ENOG4107R76	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
A3L04_05040	ENOG4107QX8	SPFH domain, Band 7 family protein
A3L04_05050	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
A3L04_05055	ENOG4108YZ8	Superoxide reductase
A3L04_05060	ENOG4105VCQ	rubredoxin
A3L04_05070	ENOG4105EHU	Circadian clock protein KaiC
A3L04_05085	ENOG4105CNW	domain protein
A3L04_05090	ENOG4105EMU	Dehydrogenase
A3L04_05100	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
A3L04_05105	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
A3L04_05160	ENOG4105RD7	BadF BadG BcrA BcrD
A3L04_05170	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
A3L04_05185	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
A3L04_05195	ENOG4107R72	Ceramidase
A3L04_05210	ENOG4108SU4	UPF0309 protein
A3L04_05215	ENOG4105CE4	GlcNAc 6-P deacetylase
A3L04_05225	ENOG4105EPC	oxidoreductase
A3L04_05260	ENOG4105CDJ	oxidoreductase FAD NAD(P)-binding domain protein
A3L04_05265	ENOG4105BZ8	glutamate synthase
A3L04_05295	ENOG4105D3R	alkyl hydroperoxide reductase
A3L04_05315	ENOG4105DA5	(ABC) transporter
A3L04_05325	ENOG4105C5X	domain protein
A3L04_05335	ENOG4107Y9E	nuclease
A3L04_05345	ENOG4105E4P	ATPase (AAA
A3L04_05360	ENOG4108F3G	Type I restriction-modification system, R subunit
A3L04_05365	ENOG4105CVR	type I restriction-modification system
A3L04_05385	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
A3L04_05405	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
A3L04_05420	ENOG4108I5C	dEAD DEAH box helicase
A3L04_05445	ENOG4108RWI	nicotinamidase
A3L04_05450	ENOG4108EV3	Bifunctional aspartate kinase II homoserine dehydrogenase II
A3L04_05455	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
A3L04_05475	ENOG4105PGM	cation diffusion facilitator family transporter
A3L04_05485	ENOG4105DUN	Mediates zinc uptake. May also transport other divalent cations (By similarity)
A3L04_05495	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
A3L04_05585	ENOG4105P4J	Allophanate hydrolase, subunit 1
A3L04_05595	ENOG4105E7W	lamb ycsf family protein
A3L04_05600	ENOG4105E4P	ATPase (AAA
A3L04_05620	ENOG4105CJ1	ABC, transporter
A3L04_05650	ENOG4105E0A	ABC, transporter
A3L04_05655	ENOG4105EHG	Permease protein
A3L04_05660	ENOG4105S10	periplasmic binding protein
A3L04_05695	ENOG4108IUW	ABC transporter
A3L04_05715	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
A3L04_05725	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
A3L04_05735	ENOG4105D22	carbon starvation protein
A3L04_05760	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
A3L04_05770	ENOG4105DVT	helicase
A3L04_05780	ENOG4105C7K	acetolactate synthase
A3L04_05785	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
A3L04_05790	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
A3L04_05795	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
A3L04_05800	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
A3L04_05805	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
A3L04_05810	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
A3L04_05815	ENOG4105C01	Dihydroxy-acid dehydratase
A3L04_05845	ENOG4105CMQ	Chloride channel
A3L04_05850	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
A3L04_05860	ENOG4105DDK	oxidoreductase, beta subunit
A3L04_05865	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
A3L04_05875	ENOG4105DDK	oxidoreductase, beta subunit
A3L04_05880	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
A3L04_05895	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
A3L04_05900	ENOG4105CHU	acetyl-coa acetyltransferase
A3L04_05920	ENOG4105DWU	Membrane
A3L04_05930	ENOG4108WBT	adenosyltransferase
A3L04_05945	ENOG4105DP8	Major facilitator superfamily MFS_1
A3L04_05975	ENOG4105Y7X	Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity)
A3L04_05985	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
A3L04_05995	ENOG4105CPQ	Dehydrogenase
A3L04_06030	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
A3L04_06035	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
A3L04_06045	ENOG4105ERH	Fumarylacetoacetate hydrolase
A3L04_06065	ENOG4107QXV	Phosphate transporter
A3L04_06070	ENOG4107IX6	phosphate transport regulator
A3L04_06080	ENOG4105C8N	cysteinyl-tRNA synthetase
A3L04_06090	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
A3L04_06125	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
A3L04_06135	ENOG4105UQX	Mate efflux family protein
A3L04_06140	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
A3L04_06165	ENOG4107ZED	Uncharacterised protein family UPF0047
A3L04_06175	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
A3L04_06190	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
A3L04_06200	ENOG4105D1F	ATP-binding protein
A3L04_06215	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
A3L04_06220	ENOG4105SC1	monovalent cation H antiporter subunit E
A3L04_06225	ENOG41080TA	Multiple resistance and ph regulation protein f
A3L04_06230	ENOG4105KJM	monovalent cation h antiporter subunit g
A3L04_06235	ENOG4105C8S	subunit m
A3L04_06250	ENOG4108JPZ	Monovalent cation H antiporter subunit D
A3L04_06260	ENOG4105DT1	RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate
A3L04_06275	ENOG4105CVK	Glutamate decarboxylase
A3L04_06295	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
A3L04_06305	ENOG4107RFY	SbcCD D subunit
A3L04_06310	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
A3L04_06475	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
A3L04_06480	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
A3L04_06490	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
A3L04_06500	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
A3L04_06530	ENOG4107QSA	Oxaloacetate decarboxylase
A3L04_06540	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
A3L04_06545	ENOG4105DWF	phosphomethylpyrimidine kinase
A3L04_06550	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
A3L04_06555	ENOG4105C4U	4-methyl-5-beta-hydroxyethylthiazole kinase
A3L04_06570	ENOG4105ETU	transcriptional activator (TenA
A3L04_06575	ENOG4108V1U	phospholipid-binding protein
A3L04_06600	ENOG4105DC7	peptidase M24
A3L04_06610	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
A3L04_06630	ENOG4107YIW	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
A3L04_06655	ENOG4108RCS	geranylgeranylglyceryl phosphate synthase
A3L04_06690	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
A3L04_06720	ENOG4107QRT	dEAD DEAH box helicase
A3L04_06730	ENOG4105K4P	CoA-binding domain protein
A3L04_06745	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
A3L04_06755	ENOG41079KZ	Major Facilitator Superfamily
A3L04_06760	ENOG4105C22	threonyL-tRNA synthetase
A3L04_06785	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
A3L04_06790	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
A3L04_06795	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
A3L04_06830	ENOG4108Z4J	Cytidine monophosphate kinase
A3L04_06855	ENOG4105DJB	Major Facilitator Superfamily
A3L04_06880	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
A3L04_06930	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
A3L04_06940	ENOG4105DIW	FeS assembly protein SUFB
A3L04_06945	ENOG4105C3K	feS assembly ATPase SufC
A3L04_06995	ENOG4105E66	phosphoriboisomerase A
A3L04_07000	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
A3L04_07070	ENOG4108J2R	molybdopterin oxidoreductase
A3L04_07075	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
A3L04_07095	ENOG4105IQJ	Involved in biosynthesis of the thiamine precursor thiazole (By similarity)
A3L04_07100	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
A3L04_07105	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
A3L04_07120	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
A3L04_07130	ENOG4105ECW	sulfate abc transporter
A3L04_07135	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
A3L04_07140	ENOG4105DP9	ABC transporter
A3L04_07160	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
A3L04_07175	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
A3L04_07225	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
A3L04_07240	ENOG4107QRT	dEAD DEAH box helicase
A3L04_07315	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A3L04_07330	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
A3L04_07340	ENOG4105DCG	PHP domain protein
A3L04_07355	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
A3L04_07410	ENOG4105C5R	Aminotransferase
A3L04_07425	ENOG4105CK2	sodium dicarboxylate symporter
A3L04_07430	ENOG4105KRN	Transcriptional regulator, abrb family
A3L04_07440	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
A3L04_07445	ENOG4105HDK	L-asparaginase
A3L04_07460	ENOG4105D7K	pfkb domain protein
A3L04_07470	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
A3L04_07475	ENOG4105SC1	monovalent cation H antiporter subunit E
A3L04_07480	ENOG410684G	monovalent cation H antiporter subunit F
A3L04_07495	ENOG4105D65	subunit l
A3L04_07500	ENOG4105MKQ	Monovalent cation H antiporter subunit C
A3L04_07505	ENOG4108JPZ	Monovalent cation H antiporter subunit D
A3L04_07510	ENOG4108JPZ	Monovalent cation H antiporter subunit D
A3L04_07515	ENOG4108IZQ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
A3L04_07520	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
A3L04_07525	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A3L04_07530	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
A3L04_07540	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
A3L04_07565	ENOG4107TDF	Formate hydrogenlyase subunit 4
A3L04_07570	ENOG4108HM5	NADH-ubiquinone oxidoreductase chain 49kDa
A3L04_07575	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
A3L04_07580	ENOG4105C47	NADH ubiquinone oxidoreductase 20 kda subunit
A3L04_07590	ENOG4108JPZ	Monovalent cation H antiporter subunit D
A3L04_07595	ENOG4105MKQ	Monovalent cation H antiporter subunit C
A3L04_07615	ENOG4105KJM	monovalent cation h antiporter subunit g
A3L04_07620	ENOG410684G	monovalent cation H antiporter subunit F
A3L04_07625	ENOG4105SC1	monovalent cation H antiporter subunit E
A3L04_07630	ENOG4105C3M	thioredoxin reductase
A3L04_07635	ENOG4108JPW	Aminotransferase
A3L04_07660	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
A3L04_07675	ENOG4108JQ7	(ABC) transporter
A3L04_07685	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
A3L04_07690	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
A3L04_07695	ENOG4105DEF	Extracellular solute-binding protein, family 5
A3L04_07700	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
A3L04_07710	ENOG4105CY0	Metallo-Beta-Lactamase
A3L04_07715	ENOG4105KPK	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
A3L04_07730	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
A3L04_07755	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
A3L04_07765	ENOG4108JQ1	Dehydrogenase
A3L04_07770	ENOG4107RFW	hydrolase family 57
A3L04_07815	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
A3L04_07835	ENOG4108MDK	Dehydrogenase
A3L04_07845	ENOG4105C75	arginyL-tRNA synthetase
A3L04_07870	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
A3L04_07875	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
A3L04_07880	ENOG4107S5Z	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity)
A3L04_07925	ENOG4107ZXI	Rhomboid family
A3L04_07935	ENOG4105CSM	endonuclease III
A3L04_07945	ENOG4105E98	transcriptional regulator DeoR family
A3L04_07950	ENOG4108JPW	Aminotransferase
A3L04_07965	ENOG4107R21	site-determining protein
A3L04_07975	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A3L04_08005	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
A3L04_08010	ENOG4105QAX	Iron-sulfur
A3L04_08015	ENOG4105D65	subunit l
A3L04_08020	ENOG4108JPZ	Monovalent cation H antiporter subunit D
A3L04_08025	ENOG4107TDF	Formate hydrogenlyase subunit 4
A3L04_08030	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
A3L04_08035	ENOG4108RG7	formate hydrogenlyase complex iron-sulfur subunit
A3L04_08040	ENOG4105C47	NADH ubiquinone oxidoreductase 20 kda subunit
A3L04_08070	ENOG4105MKQ	Monovalent cation H antiporter subunit C
A3L04_08090	ENOG41083NF	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
A3L04_08100	ENOG4105EJ7	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity)
A3L04_08125	ENOG4108RAC	Rubrerythrin
A3L04_08145	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
A3L04_08155	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
A3L04_08185	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
A3L04_08245	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
A3L04_08275	ENOG4105CAQ	asparagine synthetase
A3L04_08290	ENOG4105BZ1	(ABC) transporter
A3L04_08295	ENOG4105BZ1	(ABC) transporter
A3L04_08310	ENOG4105C9B	Cysteine desulfurase
A3L04_08315	ENOG4107XF7	NGG1p interacting factor 3 protein, NIF3
A3L04_08330	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
A3L04_08340	ENOG4105DEF	Extracellular solute-binding protein, family 5
A3L04_08345	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
A3L04_08350	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
A3L04_08360	ENOG4108JQ7	(ABC) transporter
A3L04_08380	ENOG4108Y5D	Inherit from COG: cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
A3L04_08390	ENOG4105BZA	Phosphoglycerate kinase
A3L04_08400	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
A3L04_08410	ENOG4107RDY	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
A3L04_08415	ENOG4105CFH	Aspartokinase
A3L04_08420	ENOG4105CFH	Aspartokinase
A3L04_08435	ENOG4108ZP8	Acetolactate synthase small subunit
A3L04_08485	ENOG4105FBQ	ATPase associated with various cellular activities aaa_5
A3L04_08490	ENOG4105C0D	helicase
A3L04_08550	ENOG4107RFY	SbcCD D subunit
A3L04_08555	ENOG4107WZZ	SMC domain protein
A3L04_08560	ENOG4105C5H	ABC transporter
A3L04_08575	ENOG4105BZ8	glutamate synthase
A3L04_08580	ENOG4105CDJ	oxidoreductase FAD NAD(P)-binding domain protein
A3L04_08590	ENOG4105DF0	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity)
A3L04_08620	ENOG4105WRB	Hydrogenase assembly chaperone hypC hupF
A3L04_08625	ENOG4105CQS	hydrogenase expression formation protein HypD
A3L04_08630	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
A3L04_08675	ENOG4105DR5	peptidase
A3L04_08710	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
A3L04_08725	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
A3L04_08730	ENOG4108VVK	transcriptional Regulator, AsnC
A3L04_08755	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
A3L04_08765	ENOG4105F8V	Hydrolase, tatD family
A3L04_08775	ENOG4105CE1	Ferrous iron transport protein b
A3L04_08790	ENOG4106UJV	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
A3L04_08820	ENOG4105C7N	Xanthine uracil vitamin C permease
A3L04_08825	ENOG4105CB1	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
A3L04_08840	ENOG4105EFZ	amidohydrolase
A3L04_08850	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
A3L04_08865	ENOG4105C5S	asparaginyl-tRNA synthetase
A3L04_08890	ENOG4108IGT	Dipeptidase
A3L04_08925	ENOG4105CJ1	ABC, transporter
A3L04_08955	ENOG4107SHJ	sulfite reductase subunit b
A3L04_08970	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
A3L04_08985	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
A3L04_09000	ENOG4105C28	cystathionine
A3L04_09005	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
A3L04_09015	ENOG4105ZHF	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
A3L04_09020	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
A3L04_09030	ENOG4105DTT	CRISPR-associated helicase, cas3
A3L04_09100	ENOG4105D49	3-dehydroquinate synthase
A3L04_09110	ENOG4105D0M	Protease HtpX homolog
A3L04_09115	ENOG4105WMR	Protein CrcB homolog
A3L04_09120	ENOG4105KJJ	Uncharacterized ACR, COG1993
A3L04_09145	ENOG4107EEM	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
A3L04_09160	ENOG4105E1V	na solute symporter
A3L04_09165	ENOG4105CH2	amidohydrolase
A3L04_09170	ENOG4105EW9	transcriptional regulator AsnC family
A3L04_09200	ENOG4105EWK	phytoene
A3L04_09210	ENOG4105VYW	UPF0251 protein
A3L04_09230	ENOG4107VUZ	
A3L04_09235	ENOG4105ED2	Beta-lactamase
A3L04_09250	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
A3L04_09255	ENOG4105C83	adenylosuccinate lyase
A3L04_09290	ENOG4106IPI	cyclase, family
A3L04_09295	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
A3L04_09300	ENOG4105KME	endoribonuclease L-psp
A3L04_09305	ENOG4108JJB	ABC transporter
A3L04_09310	ENOG4105D8K	carboxyl transferase
A3L04_09320	ENOG4107QSA	Oxaloacetate decarboxylase
A3L04_09325	ENOG4105D9Q	decarboxylase (Beta subunit)
A3L04_09330	ENOG4105C6K	Malic enzyme
A3L04_09405	ENOG4107ZCS	Phosphomethylpyrimidine kinase
A3L04_09420	ENOG4105CXT	aspartate transcarbamylase
A3L04_09425	ENOG4108R9M	Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity)
A3L04_09430	ENOG4105CH2	amidohydrolase
A3L04_09450	ENOG4105DBV	ornithine carbamoyltransferase
A3L04_09460	ENOG4108JVH	Protein of unknown function DUF43
A3L04_09470	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
A3L04_09480	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
A3L04_09495	ENOG4105DER	m42 family
A3L04_09520	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
A3L04_09535	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
A3L04_09555	ENOG4108HH9	Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR
A3L04_09560	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
A3L04_09565	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
A3L04_09605	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
A3L04_09665	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
A3L04_09685	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
A3L04_09750	ENOG4107QMS	site-determining protein
A3L04_09800	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
A3L04_09815	ENOG4106K5Q	Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity)
A3L04_09840	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
A3L04_09845	ENOG4105Q33	Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency
A3L04_09850	ENOG4105E0A	ABC, transporter
A3L04_09855	ENOG4105EHG	Permease protein
A3L04_09860	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
A3L04_09905	ENOG4108JPW	Aminotransferase
A3L04_09910	ENOG4105BZG	amino acid carrier protein
A3L04_09925	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
A3L04_09950	ENOG4105CHM	Aminotransferase
A3L04_09965	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
A3L04_09970	ENOG4107QJE	Chromosome Partitioning Protein
A3L04_09985	ENOG4108JJB	ABC transporter
A3L04_10000	ENOG4105G01	cobalamin (vitamin B12) biosynthesis CbiM protein
A3L04_10055	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
A3L04_10060	ENOG4107NFR	Fructose-1,6-bisphosphatase
A3L04_10100	ENOG4105VUN	Transcriptional regulator
A3L04_10105	ENOG4105C45	hydrogenase expression formation protein (HypE)
A3L04_10115	ENOG4105E0R	Deoxyhypusine synthase
A3L04_10130	ENOG4108D32	Methyltransferase
A3L04_10145	ENOG4105CIH	Imidazole acetol-phosphate transaminase
A3L04_10160	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
A3L04_10180	ENOG4107XPA	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
A3L04_10190	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
A3L04_10195	ENOG4108K7V	UPF0284 protein
A3L04_10215	ENOG4105CTD	carboxy-peptidase
A3L04_10270	ENOG4108VTU	Cdp-alcohol phosphatidyltransferase
A3L04_10285	ENOG4105CND	Glycosyl transferase, family 2
A3L04_10295	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
A3L04_10325	ENOG4108V5V	Serine Threonine protein kinase
A3L04_10330	ENOG4105C8Q	Methyl-accepting chemotaxis
A3L04_10335	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
A3L04_10340	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
A3L04_10345	ENOG4105CEV	competence damage-inducible protein
A3L04_10350	ENOG4105E5G	Alpha beta hydrolase fold
A3L04_10370	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
A3L04_10380	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
A3L04_10390	ENOG4108R96	Methyltransferase, YaeB family
A3L04_10400	ENOG4105C5F	glutamine synthetase
A3L04_10420	ENOG4107SCK	Monooxygenase
A3L04_10435	ENOG4105VFR	signal peptidase
A3L04_10455	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
A3L04_10470	ENOG4105C5I	Dehydrogenase
A3L04_10480	ENOG4105C2X	Arabinose 5-phosphate isomerase
A3L04_10485	ENOG4105MRR	Transcriptional regulator (By similarity)
A3L04_10610	ENOG4105E4P	ATPase (AAA
A3L04_10660	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
A3L04_10690	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
A3L04_10715	ENOG4105D4U	had-superfamily hydrolase, subfamily iia
A3L04_10750	ENOG4105C3G	gtp-binding protein
A3L04_10780	ENOG4105EPU	Molybdenum cofactor synthesis domain protein
A3L04_10785	ENOG4105C5I	Dehydrogenase
A3L04_10790	ENOG4105CN9	Peptidase m42 family protein
A3L04_10805	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
A3L04_10825	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)