locus-tag	class	description
A3L04_00005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A3L04_00010	COG0601	transmembrane transport
A3L04_00020	COG2723	6-phospho-beta-galactosidase activity
A3L04_00055	COG1028	Short-chain dehydrogenase reductase Sdr
A3L04_00065	COG1378	Sugar-specific transcriptional regulator TrmB
A3L04_00070	COG1131	(ABC) transporter
A3L04_00080	COG0842	Transport permease protein
A3L04_00095	COG1141	Ferredoxin
A3L04_00105	COG0543	2 iron, 2 sulfur cluster binding
A3L04_00110	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A3L04_00130	COG0463	Glycosyl transferase, family 2
A3L04_00150	COG0560	Phosphoserine phosphatase
A3L04_00155	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A3L04_00230	COG1131	(ABC) transporter
A3L04_00235	COG0556	nucleotide-excision repair
A3L04_00240	COG0483	inositol monophosphate 1-phosphatase activity
A3L04_00250	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A3L04_00280	COG0446	pyridine nucleotide-disulphide oxidoreductase
A3L04_00285	COG0579	oxidoreductase
A3L04_00305	COG0584	glycerophosphoryl diester phosphodiesterase
A3L04_00310	COG2211	Major facilitator Superfamily
A3L04_00340	COG1131	(ABC) transporter
A3L04_00355	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A3L04_00375	COG0717	Belongs to the dCTP deaminase family
A3L04_00400	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A3L04_00415	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A3L04_00460	COG2078	PFAM AMMECR1 domain protein
A3L04_00485	COG0157	Belongs to the NadC ModD family
A3L04_00495	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A3L04_00505	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A3L04_00510	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
A3L04_00535	COG3842	ATPase activity
A3L04_00540	COG0581	inorganic phosphate transmembrane transporter activity
A3L04_00575	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A3L04_00585	COG0730	response to heat
A3L04_00590	COG2414	aldehyde ferredoxin oxidoreductase
A3L04_00620	COG0667	Aldo Keto reductase
A3L04_00635	COG0746	molybdenum cofactor guanylyltransferase activity
A3L04_00660	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
A3L04_00690	COG1522	sequence-specific DNA binding
A3L04_00705	COG2234	aminopeptidase activity
A3L04_00725	COG0307	riboflavin synthase, alpha
A3L04_00730	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A3L04_00730	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A3L04_00780	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A3L04_00785	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A3L04_00785	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A3L04_00810	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A3L04_00820	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A3L04_00845	COG1694	Mazg nucleotide pyrophosphohydrolase
A3L04_00875	COG0252	asparaginase activity
A3L04_00890	COG0297	glycogen (starch) synthase activity
A3L04_00895	COG1628	Protein of unknown function DUF99
A3L04_00935	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A3L04_00935	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A3L04_00945	COG2403	cyclic 2,3-diphosphoglycerate synthetase activity
A3L04_00950	COG0725	ABC transporter, periplasmic molybdate-binding protein
A3L04_00960	COG4149	molybdate abc transporter
A3L04_00965	COG1106	Psort location Cytoplasmic, score
A3L04_00975	COG3842	ATPase activity
A3L04_00980	COG1268	BioY protein
A3L04_01000	COG1353	crispr-associated protein
A3L04_01010	COG1337	RAMP superfamily
A3L04_01050	COG1518	maintenance of DNA repeat elements
A3L04_01065	COG1203	CRISPR-associated helicase, Cas3
A3L04_01080	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A3L04_01100	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A3L04_01125	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
A3L04_01135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A3L04_01175	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A3L04_01175	COG0574	Belongs to the PEP-utilizing enzyme family
A3L04_01195	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A3L04_01215	COG0010	Belongs to the arginase family
A3L04_01220	COG1830	Aldolase
A3L04_01235	COG1605	Chorismate mutase
A3L04_01235	COG0077	Prephenate dehydratase
A3L04_01260	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A3L04_01260	COG0517	IMP dehydrogenase activity
A3L04_01265	COG0175	sulfate reduction
A3L04_01285	COG0346	lactoylglutathione lyase activity
A3L04_01295	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A3L04_01295	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A3L04_01345	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A3L04_01380	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A3L04_01410	COG1122	ATPase activity
A3L04_01430	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
A3L04_01455	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A3L04_01475	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A3L04_01510	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A3L04_01555	COG2255	four-way junction helicase activity
A3L04_01560	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A3L04_01595	COG0314	molybdopterin synthase activity
A3L04_01605	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A3L04_01610	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A3L04_01630	COG0235	Class ii aldolase
A3L04_01655	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A3L04_01660	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A3L04_01670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A3L04_01675	COG3842	ATPase activity
A3L04_01680	COG0395	ABC-type sugar transport system, permease component
A3L04_01695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A3L04_01700	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A3L04_01710	COG1378	Sugar-specific transcriptional regulator TrmB
A3L04_01720	COG0556	nucleotide-excision repair
A3L04_01725	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A3L04_01780	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
A3L04_01790	COG2226	methyltransferase
A3L04_01845	COG1028	Short-chain dehydrogenase reductase Sdr
A3L04_01865	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A3L04_01870	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A3L04_01885	COG0017	Asparaginyl-tRNA synthetase
A3L04_01900	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A3L04_01915	COG0312	modulator of DNA gyrase
A3L04_01935	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A3L04_01950	COG0750	zinc metalloprotease
A3L04_01960	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A3L04_01960	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A3L04_01975	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A3L04_01985	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A3L04_02000	COG1269	ATP hydrolysis coupled proton transport
A3L04_02010	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
A3L04_02025	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
A3L04_02030	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
A3L04_02035	COG1394	ATPase activity, coupled to movement of substances
A3L04_02040	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A3L04_02040	COG0426	domain, Protein
A3L04_02050	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A3L04_02065	COG0543	2 iron, 2 sulfur cluster binding
A3L04_02070	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A3L04_02080	COG0601	transmembrane transport
A3L04_02085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A3L04_02090	COG0444	Belongs to the ABC transporter superfamily
A3L04_02095	COG4608	Belongs to the ABC transporter superfamily
A3L04_02105	COG2140	Oxalate decarboxylase
A3L04_02115	COG0047	phosphoribosylformylglycinamidine synthase activity
A3L04_02125	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A3L04_02135	COG2151	metal-sulfur cluster biosynthetic enzyme
A3L04_02150	COG0165	Argininosuccinate lyase
A3L04_02155	COG0189	ligase activity
A3L04_02180	COG0417	DNA replication proofreading
A3L04_02185	COG1234	tRNA 3'-trailer cleavage
A3L04_02195	COG0148	phosphopyruvate hydratase activity
A3L04_02215	COG0720	synthase
A3L04_02220	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
A3L04_02245	COG1418	mRNA catabolic process
A3L04_02260	COG0640	Transcriptional regulator
A3L04_02285	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A3L04_02325	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A3L04_02330	COG1522	sequence-specific DNA binding
A3L04_02335	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A3L04_02345	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A3L04_02375	COG0539	negative regulation of cytoplasmic translation
A3L04_02380	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A3L04_02390	COG0011	TIGRFAM Protein of
A3L04_02405	COG2409	Drug exporters of the RND superfamily
A3L04_02430	COG0156	8-amino-7-oxononanoate synthase activity
A3L04_02455	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A3L04_02475	COG1449	Belongs to the glycosyl hydrolase 57 family
A3L04_02490	COG1215	transferase activity, transferring glycosyl groups
A3L04_02500	COG0037	tRNA processing
A3L04_02505	COG0475	glutathione-regulated potassium exporter activity
A3L04_02510	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
A3L04_02525	COG1254	Belongs to the acylphosphatase family
A3L04_02535	COG0516	GMP reductase activity
A3L04_02535	COG0517	IMP dehydrogenase activity
A3L04_02560	COG0069	glutamate synthase activity
A3L04_02560	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A3L04_02565	COG0067	glutamate synthase
A3L04_02570	COG0372	Belongs to the citrate synthase family
A3L04_02575	COG0538	isocitrate dehydrogenase activity
A3L04_02580	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A3L04_02585	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A3L04_02585	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A3L04_02590	COG0438	transferase activity, transferring glycosyl groups
A3L04_02600	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A3L04_02605	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A3L04_02665	COG1215	transferase activity, transferring glycosyl groups
A3L04_02670	COG0438	transferase activity, transferring glycosyl groups
A3L04_02675	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A3L04_02675	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A3L04_02695	COG0438	transferase activity, transferring glycosyl groups
A3L04_02700	COG0463	Glycosyl transferase, family 2
A3L04_02840	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A3L04_02845	COG2201	protein-glutamate methylesterase activity
A3L04_02850	COG2201	protein-glutamate methylesterase activity
A3L04_02855	COG2198	Histidine kinase
A3L04_02855	COG0643	Histidine kinase
A3L04_02860	COG1776	CheC inhibitor of MCP methylation
A3L04_02870	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
A3L04_02875	COG0840	transmembrane signaling receptor activity
A3L04_02895	COG2379	hydroxypyruvate reductase
A3L04_02920	COG2723	6-phospho-beta-galactosidase activity
A3L04_02930	COG0601	transmembrane transport
A3L04_02940	COG4608	Belongs to the ABC transporter superfamily
A3L04_02945	COG4608	Belongs to the ABC transporter superfamily
A3L04_02950	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
A3L04_02965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A3L04_02970	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A3L04_03030	COG1131	(ABC) transporter
A3L04_03045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A3L04_03050	COG0071	Belongs to the small heat shock protein (HSP20) family
A3L04_03055	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A3L04_03085	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A3L04_03120	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
A3L04_03145	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
A3L04_03155	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A3L04_03180	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A3L04_03185	COG1122	ATPase activity
A3L04_03190	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A3L04_03200	COG0315	cyclic pyranopterin monophosphate synthase activity
A3L04_03210	COG1028	Short-chain dehydrogenase reductase Sdr
A3L04_03215	COG0493	'glutamate synthase
A3L04_03225	COG0534	Mate efflux family protein
A3L04_03230	COG2894	cell division
A3L04_03260	COG1346	cytolysis
A3L04_03270	COG1196	nuclear chromosome segregation
A3L04_03305	COG0504	CTP synthase activity
A3L04_03315	COG0045	succinate-CoA ligase (ADP-forming) activity
A3L04_03315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A3L04_03315	COG1042	CoA-binding domain protein
A3L04_03340	COG1469	GTP cyclohydrolase I activity
A3L04_03355	COG1078	dGTPase activity
A3L04_03365	COG0516	GMP reductase activity
A3L04_03365	COG0517	IMP dehydrogenase activity
A3L04_03375	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A3L04_03380	COG0088	Forms part of the polypeptide exit tunnel
A3L04_03385	COG0089	rRNA binding
A3L04_03390	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A3L04_03395	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A3L04_03405	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A3L04_03410	COG0255	Belongs to the universal ribosomal protein uL29 family
A3L04_03430	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A3L04_03445	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A3L04_03455	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A3L04_03460	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A3L04_03475	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A3L04_03480	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A3L04_03490	COG0200	Binds to the 23S rRNA
A3L04_03510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A3L04_03530	COG1476	TRANSCRIPTIONal
A3L04_03560	COG0546	phosphoglycolate phosphatase activity
A3L04_03565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A3L04_03620	COG0501	Belongs to the peptidase M48B family
A3L04_03640	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
A3L04_03645	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A3L04_03670	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A3L04_03675	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A3L04_03680	COG0107	imidazoleglycerol-phosphate synthase activity
A3L04_03685	COG0140	phosphoribosyl-ATP diphosphatase activity
A3L04_03685	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A3L04_03690	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A3L04_03725	COG0697	spore germination
A3L04_03735	COG2890	protein-(glutamine-N5) methyltransferase activity
A3L04_03765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A3L04_03775	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A3L04_03780	COG0066	3-isopropylmalate dehydratase activity
A3L04_03785	COG0473	3-isopropylmalate dehydrogenase activity
A3L04_03795	COG0189	ligase activity
A3L04_03800	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A3L04_03805	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A3L04_03810	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A3L04_03815	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A3L04_03825	COG3959	Transketolase, thiamine diphosphate binding domain
A3L04_03830	COG3958	Transketolase
A3L04_03835	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A3L04_03840	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A3L04_03845	COG0710	3-dehydroquinate dehydratase activity
A3L04_03850	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A3L04_03855	COG0083	homoserine kinase activity
A3L04_03880	COG1063	alcohol dehydrogenase
A3L04_03905	COG0287	Prephenate dehydrogenase
A3L04_03905	COG1605	Chorismate mutase
A3L04_03910	COG0436	Aminotransferase
A3L04_03925	COG0133	tryptophan synthase activity
A3L04_03935	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A3L04_03935	COG0512	Glutamine amidotransferase of anthranilate synthase
A3L04_03940	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A3L04_03945	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A3L04_03960	COG0505	Belongs to the CarA family
A3L04_03970	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A3L04_03990	COG0693	protein deglycase activity
A3L04_04010	COG1032	radical SAM domain protein
A3L04_04025	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A3L04_04035	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A3L04_04040	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A3L04_04055	COG1522	sequence-specific DNA binding
A3L04_04080	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A3L04_04080	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A3L04_04090	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A3L04_04115	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A3L04_04125	COG0300	oxidoreductase activity
A3L04_04140	COG0393	Putative heavy-metal-binding
A3L04_04160	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
A3L04_04170	COG0037	tRNA processing
A3L04_04200	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A3L04_04205	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A3L04_04210	COG1872	DUF167
A3L04_04215	COG0552	protein localization to endoplasmic reticulum
A3L04_04215	COG0457	Tetratricopeptide repeat
A3L04_04225	COG0674	pyruvate-flavodoxin oxidoreductase activity
A3L04_04225	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A3L04_04230	COG1013	pyruvate-flavodoxin oxidoreductase activity
A3L04_04240	COG0674	pyruvate-flavodoxin oxidoreductase activity
A3L04_04240	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A3L04_04245	COG1013	pyruvate-flavodoxin oxidoreductase activity
A3L04_04255	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A3L04_04275	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A3L04_04310	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A3L04_04330	COG2813	Specifically methylates the guanine in position
A3L04_04340	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A3L04_04345	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A3L04_04370	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A3L04_04375	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A3L04_04395	COG0148	phosphopyruvate hydratase activity
A3L04_04400	COG0052	Belongs to the universal ribosomal protein uS2 family
A3L04_04405	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A3L04_04410	COG1355	regulation of microtubule-based process
A3L04_04415	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A3L04_04450	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A3L04_04475	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A3L04_04480	COG0423	glycine-tRNA ligase activity
A3L04_04500	COG0482	sulfurtransferase activity
A3L04_04505	COG1234	tRNA 3'-trailer cleavage
A3L04_04540	COG2894	cell division
A3L04_04550	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A3L04_04555	COG1216	Glycosyl transferase, family 2
A3L04_04570	COG0475	glutathione-regulated potassium exporter activity
A3L04_04575	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A3L04_04580	COG1522	sequence-specific DNA binding
A3L04_04590	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A3L04_04595	COG2131	deaminase
A3L04_04600	COG0501	Belongs to the peptidase M48B family
A3L04_04625	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
A3L04_04640	COG0489	protein tyrosine kinase activity
A3L04_04670	COG0628	permease
A3L04_04680	COG0616	signal peptide processing
A3L04_04700	COG2205	protein histidine kinase activity
A3L04_04730	COG0312	modulator of DNA gyrase
A3L04_04750	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
A3L04_04765	COG1185	polyribonucleotide nucleotidyltransferase activity
A3L04_04770	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A3L04_04800	COG0085	RNA polymerase activity
A3L04_04805	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A3L04_04810	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A3L04_04830	COG0049	tRNA binding
A3L04_04845	COG0585	pseudouridine synthase activity
A3L04_04855	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A3L04_04855	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
A3L04_04900	COG0778	Nitroreductase
A3L04_04930	COG1476	TRANSCRIPTIONal
A3L04_04940	COG1131	(ABC) transporter
A3L04_04955	COG0430	RNA-3'-phosphate cyclase activity
A3L04_04995	COG1522	sequence-specific DNA binding
A3L04_05015	COG0167	dihydroorotate dehydrogenase activity
A3L04_05020	COG0402	S-adenosylhomocysteine deaminase activity
A3L04_05030	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A3L04_05030	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A3L04_05035	COG0058	SHG alpha-glucan phosphorylase activity
A3L04_05040	COG0330	HflC and HflK could
A3L04_05050	COG0446	pyridine nucleotide-disulphide oxidoreductase
A3L04_05055	COG2033	superoxide reductase activity
A3L04_05060	COG1773	rubredoxin
A3L04_05070	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A3L04_05085	COG0426	domain, Protein
A3L04_05090	COG4221	oxidoreductase activity
A3L04_05100	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A3L04_05105	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A3L04_05160	COG2971	BadF BadG BcrA BcrD
A3L04_05170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A3L04_05175	COG0601	transmembrane transport
A3L04_05210	COG4821	SIS domain
A3L04_05225	COG0673	inositol 2-dehydrogenase activity
A3L04_05260	COG0543	2 iron, 2 sulfur cluster binding
A3L04_05265	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A3L04_05265	COG0493	'glutamate synthase
A3L04_05295	COG0450	alkyl hydroperoxide reductase
A3L04_05325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A3L04_05335	COG1525	nuclease
A3L04_05345	COG1373	ATPase (AAA superfamily
A3L04_05365	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
A3L04_05385	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A3L04_05405	COG0442	prolyl-tRNA aminoacylation
A3L04_05420	COG1111	helicase
A3L04_05420	COG1205	dead DEAH box helicase
A3L04_05445	COG1335	isochorismatase
A3L04_05450	COG0460	homoserine dehydrogenase
A3L04_05450	COG0527	aspartate kinase activity
A3L04_05455	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A3L04_05470	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A3L04_05475	COG1230	cation diffusion facilitator family transporter
A3L04_05485	COG0428	transporter
A3L04_05580	COG1984	allophanate hydrolase subunit 2
A3L04_05585	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A3L04_05590	COG1487	ribonuclease activity
A3L04_05595	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A3L04_05600	COG1373	ATPase (AAA superfamily
A3L04_05620	COG1131	(ABC) transporter
A3L04_05650	COG1120	ATPase activity
A3L04_05655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A3L04_05695	COG4555	ABC transporter
A3L04_05715	COG0101	tRNA pseudouridine synthase activity
A3L04_05725	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A3L04_05725	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A3L04_05735	COG1966	Carbon starvation protein
A3L04_05745	COG0003	Pfam Anion-transporting ATPase
A3L04_05760	COG0105	UTP biosynthetic process
A3L04_05770	COG1199	ATP-dependent helicase activity
A3L04_05780	COG0028	Belongs to the TPP enzyme family
A3L04_05785	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A3L04_05790	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A3L04_05795	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A3L04_05800	COG0066	3-isopropylmalate dehydratase activity
A3L04_05805	COG0473	3-isopropylmalate dehydrogenase activity
A3L04_05810	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A3L04_05850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A3L04_05860	COG1013	pyruvate-flavodoxin oxidoreductase activity
A3L04_05865	COG0674	pyruvate-flavodoxin oxidoreductase activity
A3L04_05875	COG1013	pyruvate-flavodoxin oxidoreductase activity
A3L04_05880	COG0674	pyruvate-flavodoxin oxidoreductase activity
A3L04_05895	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A3L04_05920	COG2431	L-lysine efflux transmembrane transporter activity
A3L04_05930	COG2096	Adenosyltransferase
A3L04_05985	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A3L04_05995	COG1063	alcohol dehydrogenase
A3L04_06030	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A3L04_06045	COG0179	Fumarylacetoacetate (FAA) hydrolase
A3L04_06065	COG0306	phosphate transporter
A3L04_06070	COG1392	Phosphate transport regulator
A3L04_06080	COG0215	cysteine-tRNA ligase activity
A3L04_06115	COG0469	pyruvate kinase activity
A3L04_06125	COG0446	pyridine nucleotide-disulphide oxidoreductase
A3L04_06130	COG0534	Mate efflux family protein
A3L04_06135	COG0534	Mate efflux family protein
A3L04_06140	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A3L04_06165	COG0432	Pfam Uncharacterised protein family UPF0047
A3L04_06175	COG0303	'Molybdopterin
A3L04_06190	COG0024	Methionine aminopeptidase
A3L04_06200	COG0489	protein tyrosine kinase activity
A3L04_06215	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A3L04_06220	COG1863	multisubunit Na H antiporter MnhE subunit
A3L04_06225	COG2212	antiporter activity
A3L04_06235	COG2111	Na H antiporter
A3L04_06235	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A3L04_06250	COG0651	ATP synthesis coupled electron transport
A3L04_06260	COG1850	ribulose-bisphosphate carboxylase activity
A3L04_06275	COG0076	glutamate decarboxylase activity
A3L04_06295	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A3L04_06295	COG4651	solute:proton antiporter activity
A3L04_06310	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A3L04_06475	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A3L04_06480	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A3L04_06480	COG2050	protein possibly involved in aromatic compounds catabolism
A3L04_06490	COG2226	methyltransferase
A3L04_06500	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A3L04_06505	COG0306	phosphate transporter
A3L04_06540	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A3L04_06545	COG0351	phosphomethylpyrimidine kinase
A3L04_06550	COG0352	thiamine-phosphate diphosphorylase activity
A3L04_06555	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
A3L04_06570	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A3L04_06575	COG1881	PFAM PEBP family protein
A3L04_06600	COG0006	proline dipeptidase activity
A3L04_06610	COG1234	tRNA 3'-trailer cleavage
A3L04_06630	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A3L04_06655	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
A3L04_06690	COG0563	adenylate kinase activity
A3L04_06720	COG1201	RNA secondary structure unwinding
A3L04_06730	COG1832	CoA-binding protein
A3L04_06745	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A3L04_06755	COG0477	Major facilitator Superfamily
A3L04_06760	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A3L04_06785	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A3L04_06790	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A3L04_06795	COG2414	aldehyde ferredoxin oxidoreductase
A3L04_06820	COG0123	including yeast histone deacetylase and acetoin utilization protein
A3L04_06830	COG1102	Psort location Cytoplasmic, score
A3L04_06845	COG1505	serine-type exopeptidase activity
A3L04_06855	COG2271	Major facilitator Superfamily
A3L04_06930	COG2226	methyltransferase
A3L04_06940	COG0719	Fe-S assembly protein
A3L04_06945	COG0396	ATPase activity
A3L04_06995	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A3L04_07000	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
A3L04_07000	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A3L04_07050	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A3L04_07070	COG0243	molybdopterin cofactor binding
A3L04_07075	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A3L04_07095	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
A3L04_07100	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
A3L04_07105	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
A3L04_07120	COG3383	formate dehydrogenase (NAD+) activity
A3L04_07130	COG4208	sulfate ABC transporter
A3L04_07140	COG4143	(ABC) transporter
A3L04_07160	COG0519	Catalyzes the synthesis of GMP from XMP
A3L04_07160	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A3L04_07175	COG0519	Catalyzes the synthesis of GMP from XMP
A3L04_07175	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A3L04_07225	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A3L04_07240	COG1201	RNA secondary structure unwinding
A3L04_07315	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A3L04_07330	COG0509	glycine decarboxylation via glycine cleavage system
A3L04_07340	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A3L04_07355	COG0301	tRNA thio-modification
A3L04_07410	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A3L04_07425	COG1301	dicarboxylic acid transport
A3L04_07430	COG2002	toxin-antitoxin pair type II binding
A3L04_07440	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A3L04_07445	COG0252	asparaginase activity
A3L04_07470	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A3L04_07475	COG1863	multisubunit Na H antiporter MnhE subunit
A3L04_07480	COG2212	antiporter activity
A3L04_07495	COG2111	Na H antiporter
A3L04_07495	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A3L04_07500	COG1006	Multisubunit Na H antiporter MnhC subunit
A3L04_07505	COG0651	ATP synthesis coupled electron transport
A3L04_07515	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A3L04_07520	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A3L04_07530	COG0649	NAD binding
A3L04_07565	COG0650	Formate hydrogenlyase subunit 4
A3L04_07575	COG3261	NADH dehydrogenase
A3L04_07575	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
A3L04_07580	COG3260	NADH ubiquinone oxidoreductase 20
A3L04_07590	COG0651	ATP synthesis coupled electron transport
A3L04_07615	COG1320	monovalent cation:proton antiporter activity
A3L04_07620	COG2212	antiporter activity
A3L04_07625	COG1863	multisubunit Na H antiporter MnhE subunit
A3L04_07630	COG0492	ferredoxin-NADP+ reductase activity
A3L04_07635	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A3L04_07640	COG0561	phosphatase activity
A3L04_07660	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A3L04_07675	COG4608	Belongs to the ABC transporter superfamily
A3L04_07680	COG0444	Belongs to the ABC transporter superfamily
A3L04_07690	COG0601	transmembrane transport
A3L04_07695	COG0747	negative chemotaxis
A3L04_07700	COG0528	UMP kinase activity
A3L04_07710	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A3L04_07715	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
A3L04_07730	COG1047	Peptidyl-prolyl cis-trans
A3L04_07755	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A3L04_07765	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A3L04_07770	COG1543	Belongs to the glycosyl hydrolase 57 family
A3L04_07815	COG1573	uracil-dna glycosylase
A3L04_07845	COG0018	arginyl-trna synthetase
A3L04_07870	COG0051	transcription antitermination factor activity, RNA binding
A3L04_07875	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A3L04_07880	COG0095	Lipoate-protein ligase
A3L04_07885	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A3L04_07925	COG0457	Tetratricopeptide repeat
A3L04_07925	COG0705	Rhomboid family
A3L04_07935	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A3L04_07945	COG1349	DNA-binding transcription factor activity
A3L04_07965	COG0455	bacterial-type flagellum organization
A3L04_07970	COG0489	protein tyrosine kinase activity
A3L04_07975	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A3L04_07975	COG0731	radical SAM domain protein
A3L04_08000	COG1309	transcriptional regulator
A3L04_08005	COG0243	molybdopterin cofactor binding
A3L04_08010	COG0437	4 iron, 4 sulfur cluster binding
A3L04_08015	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A3L04_08020	COG0651	ATP synthesis coupled electron transport
A3L04_08025	COG0650	Formate hydrogenlyase subunit 4
A3L04_08030	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
A3L04_08030	COG3261	NADH dehydrogenase
A3L04_08035	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A3L04_08040	COG3260	NADH ubiquinone oxidoreductase 20
A3L04_08050	COG2212	antiporter activity
A3L04_08070	COG1006	Multisubunit Na H antiporter MnhC subunit
A3L04_08090	COG0746	molybdenum cofactor guanylyltransferase activity
A3L04_08100	COG1151	hydroxylamine reductase activity
A3L04_08125	COG1592	Rubrerythrin
A3L04_08155	COG1185	polyribonucleotide nucleotidyltransferase activity
A3L04_08185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A3L04_08240	COG0312	modulator of DNA gyrase
A3L04_08245	COG0312	modulator of DNA gyrase
A3L04_08275	COG0367	asparagine synthase
A3L04_08290	COG1132	(ABC) transporter
A3L04_08295	COG1132	(ABC) transporter
A3L04_08310	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A3L04_08315	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A3L04_08330	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A3L04_08340	COG0747	negative chemotaxis
A3L04_08350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A3L04_08355	COG0444	Belongs to the ABC transporter superfamily
A3L04_08360	COG4608	Belongs to the ABC transporter superfamily
A3L04_08380	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A3L04_08380	COG1213	nucleotidyl transferase
A3L04_08390	COG0126	phosphoglycerate kinase activity
A3L04_08400	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A3L04_08410	COG0083	homoserine kinase activity
A3L04_08415	COG0527	aspartate kinase activity
A3L04_08415	COG0460	homoserine dehydrogenase
A3L04_08420	COG0460	homoserine dehydrogenase
A3L04_08420	COG0527	aspartate kinase activity
A3L04_08435	COG0440	acetolactate synthase activity
A3L04_08485	COG1401	restriction endodeoxyribonuclease activity
A3L04_08490	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A3L04_08550	COG0420	3'-5' exonuclease activity
A3L04_08555	COG0419	ATPase involved in DNA repair
A3L04_08560	COG0488	(ABC) transporter
A3L04_08575	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A3L04_08575	COG0493	'glutamate synthase
A3L04_08580	COG0543	2 iron, 2 sulfur cluster binding
A3L04_08590	COG0543	2 iron, 2 sulfur cluster binding
A3L04_08620	COG0298	carbon dioxide binding
A3L04_08625	COG0409	Hydrogenase expression formation protein
A3L04_08630	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A3L04_08635	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
A3L04_08650	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
A3L04_08675	COG0739	heme binding
A3L04_08710	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A3L04_08725	COG0163	prenyltransferase activity
A3L04_08730	COG1522	sequence-specific DNA binding
A3L04_08755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A3L04_08760	COG0434	BtpA family
A3L04_08765	COG0084	hydrolase, TatD family'
A3L04_08775	COG1918	ferrous iron import across plasma membrane
A3L04_08775	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A3L04_08820	COG2252	PERMEase
A3L04_08825	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A3L04_08840	COG1574	metal-dependent hydrolase with the TIM-barrel fold
A3L04_08850	COG2414	aldehyde ferredoxin oxidoreductase
A3L04_08860	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A3L04_08865	COG0017	Asparaginyl-tRNA synthetase
A3L04_08925	COG1131	(ABC) transporter
A3L04_08960	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
A3L04_08970	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A3L04_08985	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A3L04_09000	COG0626	cystathionine gamma-synthase activity
A3L04_09015	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
A3L04_09020	COG1518	maintenance of DNA repeat elements
A3L04_09030	COG1203	CRISPR-associated helicase, Cas3
A3L04_09090	COG2192	nodulation
A3L04_09100	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A3L04_09100	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A3L04_09110	COG0501	Belongs to the peptidase M48B family
A3L04_09115	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A3L04_09120	COG1993	acr, cog1993
A3L04_09145	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A3L04_09160	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A3L04_09170	COG1522	sequence-specific DNA binding
A3L04_09200	COG1233	COG1233 Phytoene dehydrogenase and related
A3L04_09210	COG1342	Belongs to the UPF0251 family
A3L04_09230	COG2020	methyltransferase activity
A3L04_09250	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A3L04_09250	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A3L04_09255	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A3L04_09290	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
A3L04_09295	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A3L04_09300	COG0251	oxidation-reduction process
A3L04_09305	COG1129	ABC transporter
A3L04_09310	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A3L04_09320	COG0511	ligase activity, forming carbon-carbon bonds
A3L04_09320	COG5016	pyruvate
A3L04_09325	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
A3L04_09330	COG0281	malic enzyme
A3L04_09405	COG0351	phosphomethylpyrimidine kinase
A3L04_09405	COG1992	Thiamine-phosphate synthase
A3L04_09420	COG0540	Belongs to the ATCase OTCase family
A3L04_09425	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
A3L04_09430	COG1473	amidohydrolase
A3L04_09450	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A3L04_09470	COG0284	orotidine-5'-phosphate decarboxylase activity
A3L04_09480	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A3L04_09480	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A3L04_09495	COG1363	Peptidase, m42
A3L04_09520	COG0525	valine-tRNA ligase activity
A3L04_09535	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A3L04_09555	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A3L04_09560	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A3L04_09565	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A3L04_09605	COG0714	Associated with various cellular activities
A3L04_09635	COG0668	transmembrane transport
A3L04_09640	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A3L04_09665	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A3L04_09685	COG1160	GTP binding
A3L04_09750	COG2894	cell division
A3L04_09800	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A3L04_09815	COG1110	DNA topoisomerase II activity
A3L04_09840	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A3L04_09845	COG1618	nucleotide phosphatase activity, acting on free nucleotides
A3L04_09850	COG1120	ATPase activity
A3L04_09855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A3L04_09860	COG1444	tRNA N-acetyltransferase activity
A3L04_09895	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A3L04_09905	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A3L04_09910	COG1115	amino acid carrier protein
A3L04_09925	COG0714	Associated with various cellular activities
A3L04_09945	COG2119	membrane
A3L04_09965	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A3L04_09970	COG1192	Involved in chromosome partitioning
A3L04_09985	COG1122	ATPase activity
A3L04_10000	COG0310	cobalt ion transport
A3L04_10055	COG2095	MarC family integral membrane protein
A3L04_10060	COG1980	fructose-bisphosphate aldolase activity
A3L04_10100	COG1695	Transcriptional regulator
A3L04_10115	COG1899	peptidyl-lysine modification to peptidyl-hypusine
A3L04_10130	COG2226	methyltransferase
A3L04_10145	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A3L04_10160	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
A3L04_10180	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
A3L04_10190	COG1492	cobalamin metabolic process
A3L04_10195	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
A3L04_10215	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
A3L04_10250	COG1051	belongs to the nudix hydrolase family
A3L04_10250	COG1056	cytidyltransferase-related domain
A3L04_10270	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A3L04_10285	COG1215	transferase activity, transferring glycosyl groups
A3L04_10335	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A3L04_10345	COG1058	Belongs to the CinA family
A3L04_10345	COG1546	Belongs to the CinA family
A3L04_10350	COG2267	carboxylic ester hydrolase activity
A3L04_10370	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A3L04_10380	COG0009	L-threonylcarbamoyladenylate synthase
A3L04_10400	COG0174	glutamine synthetase
A3L04_10420	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A3L04_10435	COG0681	Belongs to the peptidase S26 family
A3L04_10455	COG0823	Involved in the tonB-independent uptake of proteins
A3L04_10455	COG1506	peptidase
A3L04_10455	COG4946	Tricorn protease homolog
A3L04_10470	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A3L04_10480	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A3L04_10480	COG0517	IMP dehydrogenase activity
A3L04_10485	COG0864	Transcriptional regulator
A3L04_10610	COG1373	ATPase (AAA superfamily
A3L04_10660	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A3L04_10660	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A3L04_10690	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A3L04_10715	COG0647	UMP catabolic process
A3L04_10750	COG0012	GTP binding
A3L04_10780	COG0521	Mo-molybdopterin cofactor biosynthetic process
A3L04_10785	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A3L04_10790	COG1363	Peptidase, m42
A3L04_10795	COG0730	response to heat
A3L04_10805	COG0237	dephospho-CoA kinase activity
A3L04_10825	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity