locus-tag	class	description
CL1_0002	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
CL1_0008	ENOG4105DQU	oxidoreductase, subunit beta
CL1_0009	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
CL1_0011	ENOG4105DQU	oxidoreductase, subunit beta
CL1_0012	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
CL1_0017	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
CL1_0019	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
CL1_0021	ENOG4107TFB	basic membrane
CL1_0022	ENOG4108JQ9	ABC transporter
CL1_0023	ENOG4105UIB	(ABC) transporter
CL1_0025	ENOG4107SIG	periplasmic solute binding protein
CL1_0028	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
CL1_0029	ENOG4105C8N	cysteinyl-tRNA synthetase
CL1_0035	ENOG4105DWF	phosphomethylpyrimidine kinase
CL1_0036	ENOG4105IQJ	Involved in biosynthesis of the thiamine precursor thiazole (By similarity)
CL1_0038	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
CL1_0039	ENOG4105C8V	SAICAR synthetase
CL1_0043	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
CL1_0044	ENOG4108R6K	riboflavin synthase, subunit alpha
CL1_0049	ENOG4107QJZ	Glycosyl transferase, family 2
CL1_0056	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
CL1_0071	ENOG4105VXP	Protein of unknown function DUF86
CL1_0072	ENOG4105DER	m42 family
CL1_0074	ENOG4105EYF	MMPL domain protein
CL1_0082	ENOG4108WBT	adenosyltransferase
CL1_0084	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
CL1_0085	ENOG4105CEV	competence damage-inducible protein
CL1_0087	ENOG4105VZ9	UPF0235 protein
CL1_0090	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
CL1_0094	ENOG4105UQX	Mate efflux family protein
CL1_0098	ENOG4108K3F	N(2),N(2)-dimethylguanosine tRNA methyltransferase
CL1_0101	ENOG4105DC7	peptidase M24
CL1_0107	ENOG4105CE1	Ferrous iron transport protein b
CL1_0114	ENOG4105HF0	Membrane
CL1_0117	ENOG4105CN9	Peptidase m42 family protein
CL1_0118	ENOG4105C5I	Dehydrogenase
CL1_0119	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
CL1_0123	ENOG4105CHM	Aminotransferase
CL1_0125	ENOG4107RB4	Cytidine monophosphate kinase
CL1_0126	ENOG4105DZH	s-adenosylmethionine synthetase (EC 2.5.1.6)
CL1_0128	ENOG4105Y7X	Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity)
CL1_0132	ENOG4105C1A	potassium transporter peripheral membrane
CL1_0137	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
CL1_0149	ENOG4105DIW	FeS assembly protein SUFB
CL1_0150	ENOG4105C3K	feS assembly ATPase SufC
CL1_0151	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
CL1_0153	ENOG4105KME	endoribonuclease L-psp
CL1_0155	ENOG4105YVS	arsR family transcriptional regulator
CL1_0157	ENOG4108VVK	transcriptional Regulator, AsnC
CL1_0159	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
CL1_0163	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
CL1_0179	ENOG4105C75	arginyL-tRNA synthetase
CL1_0183	ENOG4108IJ1	Dehydrogenase
CL1_0184	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
CL1_0188	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
CL1_0190	ENOG4105SC1	monovalent cation H antiporter subunit E
CL1_0191	ENOG410684G	monovalent cation H antiporter subunit F
CL1_0192	ENOG4105KJM	monovalent cation h antiporter subunit g
CL1_0194	ENOG4105D65	subunit l
CL1_0195	ENOG4105MKQ	Monovalent cation H antiporter subunit C
CL1_0196	ENOG4108JPZ	Monovalent cation H antiporter subunit D
CL1_0197	ENOG4108JPZ	Monovalent cation H antiporter subunit D
CL1_0199	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
CL1_0200	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CL1_0201	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
CL1_0205	ENOG4108JPW	Aminotransferase
CL1_0206	ENOG4108ZRZ	Transcriptional regulator (AsnC family)
CL1_0216	ENOG4108V1U	phospholipid-binding protein
CL1_0223	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
CL1_0225	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
CL1_0234	ENOG4105BZR	domain protein
CL1_0237	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
CL1_0248	ENOG4105E3H	phosphoglycerate mutase
CL1_0251	ENOG41087GE	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
CL1_0254	ENOG4105DBV	ornithine carbamoyltransferase
CL1_0256	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
CL1_0268	ENOG4105CMQ	Chloride channel
CL1_0270	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
CL1_0272	ENOG4107XB0	Lipopolysaccharide 1,2-N-acetylglucosaminetransferase
CL1_0273	ENOG4108ZJ4	polysaccharide deacetylase
CL1_0278	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
CL1_0280	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
CL1_0286	ENOG4105HDK	L-asparaginase
CL1_0287	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
CL1_0288	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CL1_0290	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
CL1_0291	ENOG4107V9E	glucose-1-phosphate thymidylyltransferase
CL1_0293	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
CL1_0295	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
CL1_0296	ENOG4108JJB	ABC transporter
CL1_0300	ENOG4105CN9	Peptidase m42 family protein
CL1_0303	ENOG4108Z0R	Transferase
CL1_0304	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
CL1_0307	ENOG4105C22	threonyL-tRNA synthetase
CL1_0309	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
CL1_0326	ENOG4105D07	Signal peptide peptidase, SppA
CL1_0328	ENOG4105F4G	Membrane
CL1_0336	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
CL1_0337	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
CL1_0338	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
CL1_0342	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
CL1_0343	ENOG4105CPQ	Dehydrogenase
CL1_0349	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
CL1_0352	ENOG4105CH2	amidohydrolase
CL1_0355	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
CL1_0358	ENOG4105C5S	asparaginyl-tRNA synthetase
CL1_0365	ENOG4108VA3	3-hexulose-6-phosphate synthase
CL1_0370	ENOG4106K5Q	Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity)
CL1_0374	ENOG4105CD5	CoA-binding domain protein
CL1_0379	ENOG4105DTT	CRISPR-associated helicase, cas3
CL1_0381	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
CL1_0383	ENOG4105ZHF	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
CL1_0385	ENOG4108JU3	Alkyl hydroperoxide reductase
CL1_0389	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
CL1_0390	ENOG4108T9Q	UPF0278 protein
CL1_0397	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
CL1_0400	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
CL1_0401	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
CL1_0405	ENOG4105DHP	deoxycytidine triphosphate deaminase
CL1_0410	ENOG4105CX6	glutaminyL-tRNA synthetase
CL1_0412	ENOG4107R76	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
CL1_0413	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
CL1_0416	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
CL1_0418	ENOG4107U2T	alpha beta
CL1_0419	ENOG4107TE1	transport protein
CL1_0421	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
CL1_0422	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
CL1_0436	ENOG4107QK8	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CL1_0437	ENOG4107RGW	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CL1_0440	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
CL1_0442	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
CL1_0446	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
CL1_0447	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
CL1_0451	ENOG4105CHM	Aminotransferase
CL1_0459	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
CL1_0462	ENOG4105CFT	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity)
CL1_0465	ENOG4108JJB	ABC transporter
CL1_0471	ENOG4108Y83	glucose-6-phosphate isomerase
CL1_0475	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
CL1_0484	ENOG41083NF	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
CL1_0486	ENOG4105CQS	hydrogenase expression formation protein HypD
CL1_0489	ENOG41064K2	Hepn domain protein
CL1_0490	ENOG4105C45	hydrogenase expression formation protein (HypE)
CL1_0492	ENOG4105C9B	Cysteine desulfurase
CL1_0495	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CL1_0500	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
CL1_0503	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
CL1_0508	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
CL1_0509	ENOG4105UQX	Mate efflux family protein
CL1_0510	ENOG4105UQX	Mate efflux family protein
CL1_0511	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
CL1_0535	ENOG4105E66	phosphoriboisomerase A
CL1_0538	ENOG4105CY0	Metallo-Beta-Lactamase
CL1_0539	ENOG4105KPK	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
CL1_0542	ENOG4105D82	Glutamate dehydrogenase
CL1_0543	ENOG4105C8J	)-transporter
CL1_0545	ENOG4108YZA	Nitrogen regulatory protein pii
CL1_0546	ENOG4107RFW	hydrolase family 57
CL1_0549	ENOG4105MRR	Transcriptional regulator (By similarity)
CL1_0557	ENOG4105DC7	peptidase M24
CL1_0558	ENOG4105C8T	Leucyl-tRNA synthetase
CL1_0561	ENOG4105C57	major facilitator superfamily
CL1_0563	ENOG4105EAH	synthase
CL1_0566	ENOG4106UJV	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
CL1_0569	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
CL1_0570	ENOG41074MP	UPF0103 Mediator of ErbB2-driven cell motility-containing protein
CL1_0571	ENOG4108I5U	Uridine phosphorylase
CL1_0573	ENOG4105CB1	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
CL1_0576	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CL1_0579	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
CL1_0581	ENOG4108YXU	transcriptional regulator AsnC family
CL1_0586	ENOG4105CE9	30S ribosomal protein S2
CL1_0587	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
CL1_0590	ENOG4108UJD	30S ribosomal protein S9
CL1_0591	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
CL1_0594	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
CL1_0595	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
CL1_0596	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CL1_0597	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
CL1_0600	ENOG4108Z4J	Cytidine monophosphate kinase
CL1_0604	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
CL1_0605	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
CL1_0606	ENOG4105VPB	50S ribosomal protein L30
CL1_0607	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
CL1_0608	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
CL1_0611	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
CL1_0612	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
CL1_0614	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CL1_0616	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
CL1_0617	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
CL1_0618	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
CL1_0620	ENOG4108ZJT	translation initiation factor, Sui1
CL1_0621	ENOG41082SA	50s ribosomal protein l29
CL1_0622	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
CL1_0623	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
CL1_0624	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
CL1_0625	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CL1_0626	ENOG4105KZR	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
CL1_0628	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
CL1_0633	ENOG4105C5R	Aminotransferase
CL1_0639	ENOG4107QIZ	NADH dehydrogenase
CL1_0642	ENOG4105DF0	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity)
CL1_0647	ENOG4105CKX	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP
CL1_0654	ENOG4105D8K	carboxyl transferase
CL1_0656	ENOG4107QSA	Oxaloacetate decarboxylase
CL1_0657	ENOG4105D9Q	decarboxylase (Beta subunit)
CL1_0658	ENOG4108IJ8	ABC transporter
CL1_0667	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
CL1_0668	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
CL1_0679	ENOG4105DQU	oxidoreductase, subunit beta
CL1_0684	ENOG4108RWI	nicotinamidase
CL1_0686	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
CL1_0687	ENOG4105VUN	Transcriptional regulator
CL1_0692	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
CL1_0698	ENOG4105CQ2	DNA polymerase
CL1_0700	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
CL1_0702	ENOG4105NBF	ammecr1 domain protein
CL1_0708	ENOG4106SMU	thiamine transporter membrane protein
CL1_0709	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
CL1_0711	ENOG4105C7N	Xanthine uracil vitamin C permease
CL1_0720	ENOG410825M	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
CL1_0721	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
CL1_0725	ENOG4105EM7	Selenocysteine-specific translation elongation factor
CL1_0731	ENOG4105D64	Mechanosensitive ion channel
CL1_0732	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
CL1_0734	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
CL1_0747	ENOG4105IIU	Aminopeptidase
CL1_0757	ENOG4105F0N	pyrophosphate phospho-hydrolase
CL1_0758	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
CL1_0764	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
CL1_0776	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
CL1_0779	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
CL1_0781	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
CL1_0782	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
CL1_0785	ENOG4107QNG	Phosphoribosylglycinamide synthetase
CL1_0786	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
CL1_0787	ENOG4108HH9	Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR
CL1_0788	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
CL1_0791	ENOG4107QRT	dEAD DEAH box helicase
CL1_0792	ENOG4105C8V	SAICAR synthetase
CL1_0794	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
CL1_0795	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
CL1_0796	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
CL1_0797	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
CL1_0799	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
CL1_0800	ENOG4108IYU	L-aspartate oxidase
CL1_0803	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
CL1_0806	ENOG4105MRR	Transcriptional regulator (By similarity)
CL1_0816	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
CL1_0818	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
CL1_0824	ENOG4105J5G	Transferase hexapeptide repeat containing protein
CL1_0828	ENOG4105K64	Glycosyl transferase, family 2
CL1_0830	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
CL1_0836	ENOG4105GH9	galactofuranosyltransferase
CL1_0837	ENOG4105CBG	Sulfatase
CL1_0840	ENOG4105CNB	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
CL1_0846	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
CL1_0856	ENOG4105CPK	Glycosyl transferase (Group 1
CL1_0862	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
CL1_0865	ENOG41081HM	2'-5' rna ligase
CL1_0866	ENOG4105E4P	ATPase (AAA
CL1_0867	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
CL1_0874	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
CL1_0877	ENOG4105M0J	Toxic component of a toxin-antitoxin (TA) module. A
CL1_0880	ENOG4107QSQ	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
CL1_0882	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
CL1_0883	ENOG4108NGU	Transcriptional regulator
CL1_0885	ENOG4107FKK	extracellular solute-binding protein family 1
CL1_0887	ENOG4105EG2	ABC transporter, permease
CL1_0891	ENOG4105D6M	Phosphoglucomutase Phosphomannomutase
CL1_0893	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
CL1_0894	ENOG4105EPD	Oligopeptide transporter, Opt family
CL1_0896	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
CL1_0898	ENOG4105DR4	Methyltransferase
CL1_0902	ENOG4105EHU	Circadian clock protein KaiC
CL1_0909	ENOG4105C5F	glutamine synthetase
CL1_0911	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
CL1_0913	ENOG4108JQ7	(ABC) transporter
CL1_0914	ENOG4105C3U	ABC transporter
CL1_0915	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
CL1_0918	ENOG4105CD3	dihydroorotase
CL1_0919	ENOG4105DF0	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity)
CL1_0927	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
CL1_0928	ENOG4105M56	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
CL1_0930	ENOG4108JIQ	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity)
CL1_0931	ENOG4105KXQ	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
CL1_0933	ENOG4105K4G	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
CL1_0937	ENOG4105C1A	potassium transporter peripheral membrane
CL1_0938	ENOG4105C3D	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
CL1_0939	ENOG4107QT7	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
CL1_0940	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
CL1_0943	ENOG4105EHU	Circadian clock protein KaiC
CL1_0954	ENOG4107XF7	NGG1p interacting factor 3 protein, NIF3
CL1_0957	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
CL1_0963	ENOG4105CUT	histidyl-tRNA synthetase
CL1_0965	ENOG4107RWR	Sodium hydrogen exchanger
CL1_0966	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
CL1_0967	ENOG4105DZ0	fad dependent oxidoreductase
CL1_0970	ENOG4107R56	PP-loop domain protein
CL1_0972	ENOG4105C6W	4-alpha-glucanotransferase (EC 2.4.1.25)
CL1_0977	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
CL1_0982	ENOG4107RIQ	Sulfate adenylate transferase
CL1_0988	ENOG4107T1U	Catalyzes the synthesis of activated sulfate (By similarity)
CL1_0989	ENOG4107TSN	permease
CL1_0991	ENOG4105CBG	Sulfatase
CL1_0996	ENOG4105CBG	Sulfatase
CL1_0998	ENOG4105C0H	protease
CL1_0999	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
CL1_1007	ENOG4108KN7	Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity)
CL1_1008	ENOG4105E2Q	3-(3-hydroxy-phenyl)propionate hydroxylase
CL1_1012	ENOG4105CTD	carboxy-peptidase
CL1_1016	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
CL1_1020	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
CL1_1027	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
CL1_1031	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
CL1_1033	ENOG4105FBJ	fumarylacetoacetate (faa) hydrolase
CL1_1037	ENOG41082SX	arsR family transcriptional regulator
CL1_1040	ENOG4105E5K	Alpha-amylase
CL1_1042	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
CL1_1043	ENOG4105D1H	recombination factor protein RarA
CL1_1045	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
CL1_1047	ENOG4105CB1	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
CL1_1053	ENOG4105EYW	Ion transport protein
CL1_1081	ENOG4105CSM	endonuclease III
CL1_1087	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
CL1_1089	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
CL1_1092	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
CL1_1100	ENOG4105D06	uba thif-type nad fad binding protein
CL1_1102	ENOG4108ZAF	Molybdopterin
CL1_1106	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
CL1_1107	ENOG4108VVK	transcriptional Regulator, AsnC
CL1_1117	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
CL1_1119	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
CL1_1122	ENOG4108JPW	Aminotransferase
CL1_1123	ENOG4105C3M	thioredoxin reductase
CL1_1125	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
CL1_1130	ENOG4107TDF	Formate hydrogenlyase subunit 4
CL1_1131	ENOG4108HM5	NADH-ubiquinone oxidoreductase chain 49kDa
CL1_1132	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
CL1_1133	ENOG4105C47	NADH ubiquinone oxidoreductase 20 kda subunit
CL1_1135	ENOG4108JPZ	Monovalent cation H antiporter subunit D
CL1_1136	ENOG4105MKQ	Monovalent cation H antiporter subunit C
CL1_1140	ENOG4105KJM	monovalent cation h antiporter subunit g
CL1_1142	ENOG4105SC1	monovalent cation H antiporter subunit E
CL1_1143	ENOG4105QAX	Iron-sulfur
CL1_1144	ENOG4105BZ8	glutamate synthase
CL1_1145	ENOG4105TMB	Formate nitrite transporter
CL1_1147	ENOG4105QAX	Iron-sulfur
CL1_1148	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
CL1_1152	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
CL1_1153	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
CL1_1158	ENOG4105CJ3	phosphate transporter
CL1_1161	ENOG4108IJ8	ABC transporter
CL1_1171	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
CL1_1177	ENOG4108IGT	Dipeptidase
CL1_1180	ENOG4105VFR	signal peptidase
CL1_1181	ENOG4107S5Z	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity)
CL1_1183	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
CL1_1188	ENOG41067MG	lrgb family
CL1_1189	ENOG4105VAW	lrga family
CL1_1194	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
CL1_1195	ENOG4107S6Z	Na H antiporter
CL1_1199	ENOG4107SW0	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
CL1_1202	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
CL1_1203	ENOG4108VVK	transcriptional Regulator, AsnC
CL1_1205	ENOG4107NFR	Fructose-1,6-bisphosphatase
CL1_1207	ENOG4105EWK	phytoene
CL1_1215	ENOG4105CIG	ABC transporter
CL1_1224	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
CL1_1227	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
CL1_1228	ENOG4107YZX	Universal stress protein
CL1_1229	ENOG4108UUC	Protein of unknown function DUF99
CL1_1230	ENOG4105VF7	tolerance protein
CL1_1231	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
CL1_1233	ENOG4108RVA	ribokinase
CL1_1238	ENOG4105D1F	ATP-binding protein
CL1_1239	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
CL1_1240	ENOG4105EHG	Permease protein
CL1_1243	ENOG4105DDK	oxidoreductase, beta subunit
CL1_1244	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
CL1_1246	ENOG4105DDK	oxidoreductase, beta subunit
CL1_1247	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
CL1_1250	ENOG4105CJ3	phosphate transporter
CL1_1251	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
CL1_1258	ENOG4105CVS	RNA methyltransferase TrmH family, group 1
CL1_1259	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
CL1_1262	ENOG4106DSS	Tartrate dehydratase subunit alpha
CL1_1263	ENOG4107GFK	fumarate
CL1_1265	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
CL1_1268	ENOG4107R3E	Citrate transporter
CL1_1272	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
CL1_1284	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
CL1_1286	ENOG4107K5X	Membrane-bound metal-dependent hydrolase
CL1_1293	ENOG4108R9M	Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity)
CL1_1294	ENOG4105CXT	aspartate transcarbamylase
CL1_1300	ENOG4105C22	threonyL-tRNA synthetase
CL1_1301	ENOG4105NBF	ammecr1 domain protein
CL1_1302	ENOG4105C7B	Threonine dehydratase
CL1_1304	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
CL1_1305	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
CL1_1306	ENOG4105EHG	Permease protein
CL1_1311	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
CL1_1313	ENOG4105CDU	Replicative dna helicase
CL1_1317	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
CL1_1320	ENOG4105EHU	Circadian clock protein KaiC
CL1_1324	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
CL1_1329	ENOG4105DK7	lysyl-tRNA synthetase
CL1_1331	ENOG4107QNK	)-transporter
CL1_1333	ENOG4105D44	asparaginase
CL1_1339	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
CL1_1344	ENOG4108UK2	deaminase
CL1_1345	ENOG4105D0M	Protease HtpX homolog
CL1_1347	ENOG4105EZY	Pyrroloquinoline quinone biosynthesis protein E
CL1_1348	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
CL1_1349	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
CL1_1351	ENOG4108JVH	Protein of unknown function DUF43
CL1_1353	ENOG4105VG1	fes assembly suf system protein
CL1_1354	ENOG41084T3	4fe-4S ferredoxin iron-sulfur binding domain-containing protein
CL1_1356	ENOG4105CHR	reductase
CL1_1359	ENOG4105BZ8	glutamate synthase
CL1_1360	ENOG4105CDJ	oxidoreductase FAD NAD(P)-binding domain protein
CL1_1364	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
CL1_1365	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
CL1_1369	ENOG41080HI	glycine oxidase
CL1_1372	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
CL1_1374	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
CL1_1377	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
CL1_1379	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
CL1_1382	ENOG4105CK7	Sodium proline symporter
CL1_1385	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CL1_1387	ENOG4107R7Y	intracellular protease Pfpi family
CL1_1393	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
CL1_1394	ENOG4108UKZ	OsmC family
CL1_1397	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
CL1_1398	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
CL1_1403	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
CL1_1417	ENOG4107WCI	zn-dependent hydrolase of the beta-lactamase fold-like protein
CL1_1422	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
CL1_1423	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
CL1_1427	ENOG4108ZP8	Acetolactate synthase small subunit
CL1_1428	ENOG4105C8S	subunit m
CL1_1433	ENOG4105KJM	monovalent cation h antiporter subunit g
CL1_1434	ENOG41080TA	Multiple resistance and ph regulation protein f
CL1_1435	ENOG4105SC1	monovalent cation H antiporter subunit E
CL1_1436	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
CL1_1439	ENOG4105BZ8	glutamate synthase
CL1_1440	ENOG4105CDJ	oxidoreductase FAD NAD(P)-binding domain protein
CL1_1446	ENOG4105DEF	Extracellular solute-binding protein, family 5
CL1_1447	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
CL1_1448	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
CL1_1450	ENOG4108JQ7	(ABC) transporter
CL1_1457	ENOG4105CJ1	ABC, transporter
CL1_1458	ENOG4105VZ8	Transcriptional regulator
CL1_1464	ENOG4105CHM	Aminotransferase
CL1_1467	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
CL1_1468	ENOG4107QJE	Chromosome Partitioning Protein
CL1_1470	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
CL1_1472	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
CL1_1475	ENOG4108Y5D	Inherit from COG: cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
CL1_1478	ENOG4105CJ1	ABC, transporter
CL1_1482	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
CL1_1487	ENOG4105DT1	RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate
CL1_1488	ENOG4107104	thymidine kinase
CL1_1497	ENOG4108RMN	UPF0128 protein
CL1_1501	ENOG4105K4P	CoA-binding domain protein
CL1_1506	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
CL1_1512	ENOG41066FR	extracellular solute-binding protein
CL1_1513	ENOG4105E0C	molybdate abc transporter
CL1_1514	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
CL1_1515	ENOG4108R96	Methyltransferase, YaeB family
CL1_1517	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
CL1_1522	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
CL1_1523	ENOG4106IPI	cyclase, family
CL1_1527	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
CL1_1528	ENOG4105EAC	phosphoserine phosphatase
CL1_1545	ENOG4108WVK	Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity)
CL1_1556	ENOG4108TVJ	Nitroreductase
CL1_1558	ENOG4107SA6	carbon-phosphorus lyase complex accessory protein
CL1_1569	ENOG4107Y70	Heat shock protein
CL1_1570	ENOG4107T0X	DNA ligase
CL1_1576	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
CL1_1587	ENOG4105CD5	CoA-binding domain protein
CL1_1590	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
CL1_1592	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
CL1_1593	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
CL1_1594	ENOG4105E4P	ATPase (AAA
CL1_1598	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
CL1_1601	ENOG4105CAQ	asparagine synthetase
CL1_1603	ENOG4107QMS	site-determining protein
CL1_1607	ENOG4108Z03	MAF-like protein
CL1_1609	ENOG4105D5P	Methylmalonyl-coA mutase
CL1_1613	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
CL1_1616	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
CL1_1622	ENOG4108RCS	geranylgeranylglyceryl phosphate synthase
CL1_1626	ENOG4105CMW	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)
CL1_1629	ENOG4107QMS	site-determining protein
CL1_1630	ENOG4107QX8	SPFH domain, Band 7 family protein
CL1_1639	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
CL1_1641	ENOG4105E7W	lamb ycsf family protein
CL1_1642	ENOG4105P4J	Allophanate hydrolase, subunit 1
CL1_1645	ENOG4105C0A	alcohol dehydrogenase
CL1_1647	ENOG4108MWI	inositol mono-phosphatase
CL1_1649	ENOG4105DVT	helicase
CL1_1652	ENOG4105CN9	Peptidase m42 family protein
CL1_1653	ENOG4105PW4	Sugar fermentation stimulation protein homolog
CL1_1654	ENOG4107R8N	Glycosyl transferase, family 2
CL1_1656	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
CL1_1661	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
CL1_1663	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
CL1_1664	ENOG4105C6T	cysteine synthase
CL1_1666	ENOG4105CD5	CoA-binding domain protein
CL1_1673	ENOG4105CSM	endonuclease III
CL1_1680	ENOG4105BZA	Phosphoglycerate kinase
CL1_1683	ENOG41088CQ	domain protein
CL1_1685	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
CL1_1686	ENOG4105ECW	sulfate abc transporter
CL1_1690	ENOG4105EW9	transcriptional regulator AsnC family
CL1_1691	ENOG4108I5C	dEAD DEAH box helicase
CL1_1695	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
CL1_1696	ENOG4108JJB	ABC transporter
CL1_1697	ENOG4105VKD	bioY protein
CL1_1703	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
CL1_1706	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
CL1_1712	ENOG4105C5S	asparaginyl-tRNA synthetase
CL1_1713	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
CL1_1720	ENOG4108ZF3	Phosphatase
CL1_1721	ENOG4105D9P	serine threonine protein kinase
CL1_1723	ENOG4108ZF3	Phosphatase
CL1_1724	ENOG4105D9P	serine threonine protein kinase
CL1_1726	ENOG4105D9P	serine threonine protein kinase
CL1_1727	ENOG4105D9P	serine threonine protein kinase
CL1_1736	ENOG4105C11	sulfate adenylyltransferase), subunit 2
CL1_1744	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
CL1_1748	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
CL1_1753	ENOG4107WZZ	SMC domain protein
CL1_1758	ENOG4105F8V	Hydrolase, tatD family
CL1_1761	ENOG4105C5X	domain protein
CL1_1762	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
CL1_1766	ENOG4107QRT	dEAD DEAH box helicase
CL1_1772	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
CL1_1777	ENOG4105C83	adenylosuccinate lyase
CL1_1779	ENOG4105VYW	UPF0251 protein
CL1_1791	ENOG4107R21	site-determining protein
CL1_1795	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
CL1_1796	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
CL1_1798	ENOG4105E5G	Alpha beta hydrolase fold
CL1_1802	ENOG4105D0U	Arsenite-activated ATPase (ArsA)
CL1_1804	ENOG4105D22	carbon starvation protein
CL1_1805	ENOG4107QSA	Oxaloacetate decarboxylase
CL1_1806	ENOG41061GT	Aldolase
CL1_1807	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
CL1_1808	ENOG4105CK2	sodium dicarboxylate symporter
CL1_1810	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
CL1_1811	ENOG4105DTT	CRISPR-associated helicase, cas3
CL1_1813	ENOG4105ZHF	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
CL1_1814	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
CL1_1821	ENOG4105CIH	Imidazole acetol-phosphate transaminase
CL1_1822	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
CL1_1823	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
CL1_1824	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
CL1_1825	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
CL1_1826	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
CL1_1828	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
CL1_1834	ENOG4105CIG	ABC transporter
CL1_1840	ENOG4108YZ8	Superoxide reductase
CL1_1841	ENOG4105VCQ	rubredoxin
CL1_1842	ENOG4108RAC	Rubrerythrin
CL1_1843	ENOG4108ESE	uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center
CL1_1845	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
CL1_1846	ENOG4107Y03	Nitroreductase
CL1_1849	ENOG4105F4P	)-transporter
CL1_1853	ENOG4108MK9	spermidine N(1)-acetyltransferase
CL1_1862	ENOG4105D3R	alkyl hydroperoxide reductase
CL1_1863	ENOG4108J2R	molybdopterin oxidoreductase
CL1_1871	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
CL1_1873	ENOG4107XGZ	Hydrolase
CL1_1877	ENOG41079KZ	Major Facilitator Superfamily
CL1_1878	ENOG4107RDB	Major Facilitator
CL1_1884	ENOG4105D64	Mechanosensitive ion channel
CL1_1885	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
CL1_1886	ENOG4105KJJ	Uncharacterized ACR, COG1993
CL1_1887	ENOG4105WMR	Protein CrcB homolog
CL1_1895	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CL1_1898	ENOG4107QTZ	amino acid
CL1_1899	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
CL1_1903	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
CL1_1905	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
CL1_1910	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
CL1_1912	ENOG4105FDK	ABC transporter
CL1_1920	ENOG4105FBQ	ATPase associated with various cellular activities aaa_5
CL1_1922	ENOG4105DZA	Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity)
CL1_1927	ENOG4105CIG	ABC transporter
CL1_1928	ENOG4105DCI	Phosphohydrolase
CL1_1929	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
CL1_1931	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
CL1_1932	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
CL1_1933	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
CL1_1935	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
CL1_1942	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
CL1_1946	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
CL1_1948	ENOG4105FDK	ABC transporter
CL1_1953	ENOG410695F	Crispr-associated protein, Csm1 family
CL1_1955	ENOG4108W8W	CRISPR-associated RAMP protein, Csm3 family
CL1_1957	ENOG4105G15	CRISPR-associated RAMP protein, Csm5 family
CL1_1959	ENOG4108RBV	CRISPR-associated protein, Csx3 family
CL1_1960	ENOG41063ZP	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
CL1_1961	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
CL1_1965	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
CL1_1971	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
CL1_1972	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
CL1_1976	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
CL1_1982	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
CL1_1985	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
CL1_1990	ENOG4105D0M	Protease HtpX homolog
CL1_1991	ENOG4105D0M	Protease HtpX homolog
CL1_1992	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
CL1_1995	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
CL1_1996	ENOG4105CAY	ferredoxin--nadp reductase
CL1_1997	ENOG4105D3W	isochorismatase
CL1_1998	ENOG4105CHR	reductase
CL1_1999	ENOG4105E0R	Deoxyhypusine synthase
CL1_2003	ENOG4105KNA	-acetyltransferase
CL1_2005	ENOG4105DCI	Phosphohydrolase
CL1_2010	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
CL1_2011	ENOG4105EPU	Molybdenum cofactor synthesis domain protein
CL1_2013	ENOG4108K7V	UPF0284 protein
CL1_2014	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
CL1_2019	ENOG4108UHF	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
CL1_2022	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
CL1_2023	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
CL1_2024	ENOG4105CIH	Imidazole acetol-phosphate transaminase
CL1_2025	ENOG4105DXX	methyltransferase
CL1_2026	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
CL1_2029	ENOG4105E4P	ATPase (AAA
CL1_2035	ENOG4105CG9	aspartate racemase
CL1_2036	ENOG4105C3G	gtp-binding protein
CL1_2038	ENOG4108VVK	transcriptional Regulator, AsnC
CL1_2039	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase