locus-tag	class	description
TGAM_0001	COG0367	asparagine synthase
TGAM_0009	COG0714	Associated with various cellular activities
TGAM_0016	COG0438	transferase activity, transferring glycosyl groups
TGAM_0017	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TGAM_0019	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TGAM_0020	COG0037	tRNA processing
TGAM_0031	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TGAM_0035	COG0650	Formate hydrogenlyase subunit 4
TGAM_0037	COG3261	NADH dehydrogenase
TGAM_0037	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
TGAM_0038	COG3260	NADH ubiquinone oxidoreductase 20
TGAM_0040	COG0651	ATP synthesis coupled electron transport
TGAM_0045	COG1320	monovalent cation:proton antiporter activity
TGAM_0046	COG2212	antiporter activity
TGAM_0048	COG0651	ATP synthesis coupled electron transport
TGAM_0050	COG1006	Multisubunit Na H antiporter MnhC subunit
TGAM_0053	COG2212	antiporter activity
TGAM_0055	COG2116	formate transmembrane transporter activity
TGAM_0057	COG3260	NADH ubiquinone oxidoreductase 20
TGAM_0058	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TGAM_0059	COG3261	NADH dehydrogenase
TGAM_0059	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
TGAM_0060	COG0650	Formate hydrogenlyase subunit 4
TGAM_0061	COG0651	ATP synthesis coupled electron transport
TGAM_0062	COG0651	ATP synthesis coupled electron transport
TGAM_0063	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TGAM_0064	COG0437	4 iron, 4 sulfur cluster binding
TGAM_0065	COG3383	formate dehydrogenase (NAD+) activity
TGAM_0067	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TGAM_0068	COG3259	Nickel-dependent hydrogenase
TGAM_0069	COG0437	4 iron, 4 sulfur cluster binding
TGAM_0070	COG0493	'glutamate synthase
TGAM_0071	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TGAM_0072	COG1063	alcohol dehydrogenase
TGAM_0073	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TGAM_0074	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TGAM_0077	COG0148	phosphopyruvate hydratase activity
TGAM_0085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TGAM_0089	COG0235	Class ii aldolase
TGAM_0091	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TGAM_0093	COG1126	abc transporter atp-binding protein
TGAM_0096	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
TGAM_0102	COG0095	Lipoate-protein ligase
TGAM_0108	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TGAM_0114	COG4946	Tricorn protease homolog
TGAM_0114	COG1506	peptidase
TGAM_0114	COG0823	Involved in the tonB-independent uptake of proteins
TGAM_0119	COG0306	phosphate transporter
TGAM_0121	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TGAM_0123	COG1980	fructose-bisphosphate aldolase activity
TGAM_0129	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TGAM_0131	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
TGAM_0135	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TGAM_0137	COG0402	S-adenosylhomocysteine deaminase activity
TGAM_0139	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TGAM_0141	COG1269	ATP hydrolysis coupled proton transport
TGAM_0143	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TGAM_0145	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
TGAM_0146	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TGAM_0150	COG0482	sulfurtransferase activity
TGAM_0168	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TGAM_0172	COG0314	molybdopterin synthase activity
TGAM_0176	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TGAM_0179	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TGAM_0180	COG0492	ferredoxin-NADP+ reductase activity
TGAM_0182	COG2255	four-way junction helicase activity
TGAM_0183	COG0116	Belongs to the methyltransferase superfamily
TGAM_0186	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TGAM_0190	COG0714	Associated with various cellular activities
TGAM_0194	COG1047	Peptidyl-prolyl cis-trans
TGAM_0201	COG1160	GTP binding
TGAM_0202	COG0116	Belongs to the methyltransferase superfamily
TGAM_0208	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TGAM_0209	COG0704	Plays a role in the regulation of phosphate uptake
TGAM_0212	COG0180	Tryptophanyl-tRNA synthetase
TGAM_0217	COG1234	tRNA 3'-trailer cleavage
TGAM_0219	COG0640	Transcriptional regulator
TGAM_0221	COG0640	Transcriptional regulator
TGAM_0224	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TGAM_0224	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TGAM_0225	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TGAM_0225	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TGAM_0229	COG0489	protein tyrosine kinase activity
TGAM_0230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TGAM_0232	COG0864	Transcriptional regulator
TGAM_0234	COG0489	protein tyrosine kinase activity
TGAM_0239	COG0746	molybdenum cofactor guanylyltransferase activity
TGAM_0242	COG3260	NADH ubiquinone oxidoreductase 20
TGAM_0243	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TGAM_0244	COG3261	NADH dehydrogenase
TGAM_0244	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
TGAM_0245	COG0650	Formate hydrogenlyase subunit 4
TGAM_0246	COG0651	ATP synthesis coupled electron transport
TGAM_0247	COG2111	Na H antiporter
TGAM_0247	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TGAM_0248	COG0437	4 iron, 4 sulfur cluster binding
TGAM_0249	COG3383	formate dehydrogenase (NAD+) activity
TGAM_0250	COG1309	transcriptional regulator
TGAM_0253	COG0298	carbon dioxide binding
TGAM_0254	COG0409	Hydrogenase expression formation protein
TGAM_0255	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
TGAM_0260	COG0309	Hydrogenase expression formation protein (HypE)
TGAM_0261	COG1013	pyruvate-flavodoxin oxidoreductase activity
TGAM_0262	COG0674	pyruvate-flavodoxin oxidoreductase activity
TGAM_0264	COG1013	pyruvate-flavodoxin oxidoreductase activity
TGAM_0265	COG0674	pyruvate-flavodoxin oxidoreductase activity
TGAM_0266	COG1144	Oxidoreductase
TGAM_0268	COG0306	phosphate transporter
TGAM_0269	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TGAM_0271	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TGAM_0274	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TGAM_0280	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TGAM_0283	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TGAM_0284	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TGAM_0286	COG1042	CoA-binding domain protein
TGAM_0286	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TGAM_0286	COG0045	succinate-CoA ligase (ADP-forming) activity
TGAM_0288	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TGAM_0293	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
TGAM_0302	COG0517	IMP dehydrogenase activity
TGAM_0302	COG0516	GMP reductase activity
TGAM_0303	COG0475	glutathione-regulated potassium exporter activity
TGAM_0304	COG0475	glutathione-regulated potassium exporter activity
TGAM_0305	COG2095	MarC family integral membrane protein
TGAM_0308	COG1115	amino acid carrier protein
TGAM_0310	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TGAM_0319	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
TGAM_0319	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
TGAM_0320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TGAM_0324	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
TGAM_0325	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TGAM_0329	COG0543	2 iron, 2 sulfur cluster binding
TGAM_0332	COG0601	transmembrane transport
TGAM_0333	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TGAM_0334	COG0444	Belongs to the ABC transporter superfamily
TGAM_0335	COG4608	Belongs to the ABC transporter superfamily
TGAM_0338	COG0174	glutamine synthetase
TGAM_0346	COG1254	Belongs to the acylphosphatase family
TGAM_0347	COG1324	tolerance protein
TGAM_0348	COG1628	Protein of unknown function DUF99
TGAM_0349	COG0589	response to stress
TGAM_0353	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TGAM_0356	COG0167	dihydroorotate dehydrogenase activity
TGAM_0364	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TGAM_0367	COG2814	Major facilitator Superfamily
TGAM_0368	COG1404	Belongs to the peptidase S8 family
TGAM_0373	COG2151	metal-sulfur cluster biosynthetic enzyme
TGAM_0374	COG1141	Ferredoxin
TGAM_0381	COG2971	BadF BadG BcrA BcrD
TGAM_0383	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TGAM_0386	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TGAM_0389	COG0673	inositol 2-dehydrogenase activity
TGAM_0392	COG4821	SIS domain
TGAM_0398	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TGAM_0399	COG0281	malic enzyme
TGAM_0401	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TGAM_0401	COG0493	'glutamate synthase
TGAM_0402	COG0543	2 iron, 2 sulfur cluster binding
TGAM_0409	COG0297	glycogen (starch) synthase activity
TGAM_0420	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TGAM_0421	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
TGAM_0422	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TGAM_0425	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TGAM_0429	COG0123	including yeast histone deacetylase and acetoin utilization protein
TGAM_0431	COG0010	Belongs to the arginase family
TGAM_0433	COG0038	chloride channel
TGAM_0435	COG2002	toxin-antitoxin pair type II binding
TGAM_0436	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TGAM_0440	COG0438	transferase activity, transferring glycosyl groups
TGAM_0441	COG0726	polysaccharide deacetylase
TGAM_0453	COG1401	restriction endodeoxyribonuclease activity
TGAM_0460	COG0183	Belongs to the thiolase family
TGAM_0461	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TGAM_0467	COG1522	sequence-specific DNA binding
TGAM_0473	COG2252	PERMEase
TGAM_0480	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TGAM_0483	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TGAM_0486	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TGAM_0487	COG0081	regulation of translation
TGAM_0490	COG0717	Belongs to the dCTP deaminase family
TGAM_0504	COG2890	protein-(glutamine-N5) methyltransferase activity
TGAM_0505	COG1851	Uncharacterised protein family (UPF0128)
TGAM_0508	COG1435	thymidine kinase activity
TGAM_0510	COG0330	HflC and HflK could
TGAM_0512	COG0175	sulfate reduction
TGAM_0522	COG1695	Transcriptional regulator
TGAM_0524	COG0393	Putative heavy-metal-binding
TGAM_0530	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TGAM_0531	COG2264	protein methyltransferase activity
TGAM_0534	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TGAM_0535	COG1492	cobalamin metabolic process
TGAM_0536	COG0746	molybdenum cofactor guanylyltransferase activity
TGAM_0537	COG2342	PFAM TM1410 hypothetical-related protein
TGAM_0538	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TGAM_0543	COG1573	uracil-dna glycosylase
TGAM_0544	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TGAM_0545	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TGAM_0555	COG0719	Fe-S assembly protein
TGAM_0556	COG0396	ATPase activity
TGAM_0559	COG0339	signal peptide processing
TGAM_0560	COG0730	response to heat
TGAM_0561	COG0730	response to heat
TGAM_0563	COG2002	toxin-antitoxin pair type II binding
TGAM_0565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TGAM_0568	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TGAM_0568	COG0731	radical SAM domain protein
TGAM_0569	COG0489	protein tyrosine kinase activity
TGAM_0570	COG0489	protein tyrosine kinase activity
TGAM_0571	COG1342	Belongs to the UPF0251 family
TGAM_0576	COG1201	RNA secondary structure unwinding
TGAM_0577	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
TGAM_0583	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TGAM_0587	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
TGAM_0594	COG0363	glucosamine-6-phosphate deaminase activity
TGAM_0595	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TGAM_0597	COG0297	glycogen (starch) synthase activity
TGAM_0598	COG1378	Sugar-specific transcriptional regulator TrmB
TGAM_0600	COG2182	Extracellular solute-binding protein
TGAM_0601	COG1175	transmembrane transport
TGAM_0604	COG3842	ATPase activity
TGAM_0606	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TGAM_0607	COG1234	tRNA 3'-trailer cleavage
TGAM_0608	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TGAM_0612	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TGAM_0617	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TGAM_0620	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TGAM_0621	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TGAM_0623	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TGAM_0629	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TGAM_0630	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TGAM_0631	COG3383	formate dehydrogenase (NAD+) activity
TGAM_0634	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TGAM_0635	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TGAM_0637	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TGAM_0638	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
TGAM_0642	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TGAM_0645	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TGAM_0662	COG3842	ATPase activity
TGAM_0679	COG2264	protein methyltransferase activity
TGAM_0682	COG0525	valine-tRNA ligase activity
TGAM_0689	COG2226	methyltransferase
TGAM_0691	COG0012	GTP binding
TGAM_0698	COG0018	arginyl-trna synthetase
TGAM_0701	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TGAM_0703	COG1863	multisubunit Na H antiporter MnhE subunit
TGAM_0704	COG2212	antiporter activity
TGAM_0705	COG1320	monovalent cation:proton antiporter activity
TGAM_0707	COG2111	Na H antiporter
TGAM_0707	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TGAM_0708	COG1006	Multisubunit Na H antiporter MnhC subunit
TGAM_0709	COG0651	ATP synthesis coupled electron transport
TGAM_0712	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TGAM_0714	COG0649	NAD binding
TGAM_0719	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TGAM_0722	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TGAM_0722	COG0517	IMP dehydrogenase activity
TGAM_0723	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TGAM_0725	COG2403	cyclic 2,3-diphosphoglycerate synthetase activity
TGAM_0728	COG0017	Asparaginyl-tRNA synthetase
TGAM_0729	COG0402	S-adenosylhomocysteine deaminase activity
TGAM_0730	COG0516	GMP reductase activity
TGAM_0730	COG0517	IMP dehydrogenase activity
TGAM_0731	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TGAM_0733	COG0656	L-ascorbic acid biosynthetic process
TGAM_0742	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TGAM_0742	COG1042	CoA-binding domain protein
TGAM_0742	COG0045	succinate-CoA ligase (ADP-forming) activity
TGAM_0747	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TGAM_0750	COG0151	Belongs to the GarS family
TGAM_0755	COG0047	phosphoribosylformylglycinamidine synthase activity
TGAM_0756	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TGAM_0759	COG0517	IMP dehydrogenase activity
TGAM_0759	COG0516	GMP reductase activity
TGAM_0760	COG0519	Catalyzes the synthesis of GMP from XMP
TGAM_0760	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TGAM_0763	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TGAM_0763	COG0519	Catalyzes the synthesis of GMP from XMP
TGAM_0784	COG1832	CoA-binding protein
TGAM_0790	COG0432	Pfam Uncharacterised protein family UPF0047
TGAM_0799	COG2815	serine threonine protein kinase
TGAM_0799	COG0515	serine threonine protein kinase
TGAM_0802	COG1489	DNA binding
TGAM_0809	COG1185	polyribonucleotide nucleotidyltransferase activity
TGAM_0819	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TGAM_0820	COG4139	cobalamin transport
TGAM_0823	COG0437	4 iron, 4 sulfur cluster binding
TGAM_0824	COG1151	hydroxylamine reductase activity
TGAM_0825	COG1141	Ferredoxin
TGAM_0826	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TGAM_0826	COG0493	'glutamate synthase
TGAM_0827	COG0437	4 iron, 4 sulfur cluster binding
TGAM_0830	COG1230	cation diffusion facilitator family transporter
TGAM_0838	COG0798	PFAM Bile acid sodium symporter
TGAM_0844	COG0719	Fe-S assembly protein
TGAM_0845	COG1137	ATPase activity
TGAM_0846	COG0167	dihydroorotate dehydrogenase activity
TGAM_0846	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TGAM_0851	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TGAM_0856	COG0024	Methionine aminopeptidase
TGAM_0857	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TGAM_0865	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TGAM_0867	COG0428	transporter
TGAM_0870	COG1111	helicase
TGAM_0870	COG1205	dead DEAH box helicase
TGAM_0872	COG4608	Belongs to the ABC transporter superfamily
TGAM_0873	COG0444	Belongs to the ABC transporter superfamily
TGAM_0876	COG0747	negative chemotaxis
TGAM_0895	COG0543	2 iron, 2 sulfur cluster binding
TGAM_0896	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TGAM_0896	COG0493	'glutamate synthase
TGAM_0901	COG0438	transferase activity, transferring glycosyl groups
TGAM_0903	COG0509	glycine decarboxylation via glycine cleavage system
TGAM_0904	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TGAM_0915	COG1515	deoxyribonuclease V activity
TGAM_0917	COG0252	asparaginase activity
TGAM_0920	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TGAM_0921	COG1215	transferase activity, transferring glycosyl groups
TGAM_0925	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TGAM_0927	COG0312	modulator of DNA gyrase
TGAM_0929	COG4946	Tricorn protease homolog
TGAM_0929	COG1506	peptidase
TGAM_0929	COG0823	Involved in the tonB-independent uptake of proteins
TGAM_0936	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TGAM_0938	COG2226	methyltransferase
TGAM_0939	COG0011	TIGRFAM Protein of
TGAM_0942	COG1966	Carbon starvation protein
TGAM_0945	COG0003	Pfam Anion-transporting ATPase
TGAM_0950	COG2267	carboxylic ester hydrolase activity
TGAM_0952	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TGAM_0963	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TGAM_0966	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TGAM_0968	COG0515	serine threonine protein kinase
TGAM_0968	COG2815	serine threonine protein kinase
TGAM_0974	COG2815	serine threonine protein kinase
TGAM_0974	COG0515	serine threonine protein kinase
TGAM_0979	COG2815	serine threonine protein kinase
TGAM_0979	COG0515	serine threonine protein kinase
TGAM_0980	COG0631	protein serine/threonine phosphatase activity
TGAM_0981	COG0515	serine threonine protein kinase
TGAM_0981	COG2815	serine threonine protein kinase
TGAM_0989	COG0515	serine threonine protein kinase
TGAM_0989	COG2815	serine threonine protein kinase
TGAM_0991	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TGAM_0992	COG1522	sequence-specific DNA binding
TGAM_0994	COG2234	aminopeptidase activity
TGAM_0997	COG0560	Phosphoserine phosphatase
TGAM_1007	COG0668	transmembrane transport
TGAM_1008	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TGAM_1012	COG0459	protein refolding
TGAM_1014	COG3842	ATPase activity
TGAM_1015	COG1178	ABC-type Fe3 transport system permease component
TGAM_1018	COG1028	Short-chain dehydrogenase reductase Sdr
TGAM_1019	COG0493	'glutamate synthase
TGAM_1020	COG1899	peptidyl-lysine modification to peptidyl-hypusine
TGAM_1021	COG0277	FAD linked oxidase domain protein
TGAM_1023	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TGAM_1026	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TGAM_1031	COG0315	cyclic pyranopterin monophosphate synthase activity
TGAM_1033	COG1193	negative regulation of DNA recombination
TGAM_1034	COG0534	Mate efflux family protein
TGAM_1038	COG1505	serine-type exopeptidase activity
TGAM_1039	COG0534	Mate efflux family protein
TGAM_1040	COG0534	Mate efflux family protein
TGAM_1043	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TGAM_1043	COG0574	Belongs to the PEP-utilizing enzyme family
TGAM_1044	COG1404	Belongs to the peptidase S8 family
TGAM_1050	COG0446	pyridine nucleotide-disulphide oxidoreductase
TGAM_1051	COG0442	prolyl-tRNA aminoacylation
TGAM_1053	COG2192	nodulation
TGAM_1054	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TGAM_1055	COG0051	transcription antitermination factor activity, RNA binding
TGAM_1056	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TGAM_1057	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TGAM_1060	COG2095	MarC family integral membrane protein
TGAM_1069	COG0693	protein deglycase activity
TGAM_1072	COG0546	phosphoglycolate phosphatase activity
TGAM_1074	COG2131	deaminase
TGAM_1075	COG0501	Belongs to the peptidase M48B family
TGAM_1077	COG0436	Aminotransferase
TGAM_1078	COG2140	Oxalate decarboxylase
TGAM_1079	COG1994	Peptidase M50
TGAM_1082	COG1234	tRNA 3'-trailer cleavage
TGAM_1086	COG3842	ATPase activity
TGAM_1087	COG1178	ABC-type Fe3 transport system permease component
TGAM_1089	COG1121	(ABC) transporter
TGAM_1091	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TGAM_1095	COG0006	proline dipeptidase activity
TGAM_1105	COG1918	ferrous iron import across plasma membrane
TGAM_1105	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TGAM_1109	COG0163	prenyltransferase activity
TGAM_1110	COG1522	sequence-specific DNA binding
TGAM_1122	COG1131	(ABC) transporter
TGAM_1124	COG1476	TRANSCRIPTIONal
TGAM_1129	COG1013	pyruvate-flavodoxin oxidoreductase activity
TGAM_1135	COG1335	isochorismatase
TGAM_1139	COG1129	ABC transporter
TGAM_1141	COG0343	queuine tRNA-ribosyltransferase activity
TGAM_1142	COG0306	phosphate transporter
TGAM_1147	COG2894	cell division
TGAM_1148	COG1063	alcohol dehydrogenase
TGAM_1149	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TGAM_1151	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TGAM_1152	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TGAM_1153	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TGAM_1162	COG1056	cytidyltransferase-related domain
TGAM_1162	COG1051	belongs to the nudix hydrolase family
TGAM_1165	COG1213	nucleotidyl transferase
TGAM_1165	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TGAM_1167	COG0513	Belongs to the DEAD box helicase family
TGAM_1172	COG1196	nuclear chromosome segregation
TGAM_1175	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
TGAM_1179	COG1473	amidohydrolase
TGAM_1182	COG1984	allophanate hydrolase subunit 2
TGAM_1183	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TGAM_1185	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TGAM_1187	COG0860	N-Acetylmuramoyl-L-alanine amidase
TGAM_1187	COG2247	cell wall binding repeat
TGAM_1188	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TGAM_1192	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TGAM_1193	COG0482	sulfurtransferase activity
TGAM_1201	COG0045	succinate-CoA ligase (ADP-forming) activity
TGAM_1201	COG1042	CoA-binding domain protein
TGAM_1201	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TGAM_1205	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
TGAM_1208	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TGAM_1211	COG0084	hydrolase, TatD family'
TGAM_1216	COG2033	superoxide reductase activity
TGAM_1218	COG1028	Short-chain dehydrogenase reductase Sdr
TGAM_1220	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TGAM_1226	COG2226	methyltransferase
TGAM_1231	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TGAM_1232	COG1294	oxidase, subunit
TGAM_1233	COG1271	oxidase subunit
TGAM_1235	COG0446	pyridine nucleotide-disulphide oxidoreductase
TGAM_1240	COG0142	geranyltranstransferase activity
TGAM_1241	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TGAM_1243	COG2212	antiporter activity
TGAM_1244	COG1320	monovalent cation:proton antiporter activity
TGAM_1247	COG1006	Multisubunit Na H antiporter MnhC subunit
TGAM_1248	COG1863	multisubunit Na H antiporter MnhE subunit
TGAM_1249	COG0651	ATP synthesis coupled electron transport
TGAM_1252	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TGAM_1253	COG0450	alkyl hydroperoxide reductase
TGAM_1254	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TGAM_1254	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TGAM_1255	COG0307	riboflavin synthase, alpha
TGAM_1256	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TGAM_1256	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TGAM_1257	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TGAM_1259	COG0668	transmembrane transport
TGAM_1261	COG1215	transferase activity, transferring glycosyl groups
TGAM_1268	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TGAM_1269	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TGAM_1270	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
TGAM_1271	COG0351	phosphomethylpyrimidine kinase
TGAM_1272	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TGAM_1274	COG0778	Nitroreductase
TGAM_1277	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TGAM_1299	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TGAM_1308	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TGAM_1311	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TGAM_1313	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TGAM_1317	COG1078	dGTPase activity
TGAM_1318	COG0126	phosphoglycerate kinase activity
TGAM_1319	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TGAM_1320	COG0019	diaminopimelate decarboxylase activity
TGAM_1325	COG0602	queuosine metabolic process
TGAM_1331	COG0436	Aminotransferase
TGAM_1332	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TGAM_1332	COG2050	protein possibly involved in aromatic compounds catabolism
TGAM_1333	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TGAM_1337	COG1444	tRNA N-acetyltransferase activity
TGAM_1341	COG1794	racemase activity, acting on amino acids and derivatives
TGAM_1352	COG0312	modulator of DNA gyrase
TGAM_1356	COG1794	racemase activity, acting on amino acids and derivatives
TGAM_1357	COG2096	Adenosyltransferase
TGAM_1367	COG1363	Peptidase, m42
TGAM_1368	COG0720	synthase
TGAM_1369	COG1131	(ABC) transporter
TGAM_1376	COG1013	pyruvate-flavodoxin oxidoreductase activity
TGAM_1377	COG0674	pyruvate-flavodoxin oxidoreductase activity
TGAM_1377	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TGAM_1380	COG1013	pyruvate-flavodoxin oxidoreductase activity
TGAM_1381	COG0674	pyruvate-flavodoxin oxidoreductase activity
TGAM_1381	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TGAM_1388	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TGAM_1392	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
TGAM_1397	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TGAM_1398	COG1078	dGTPase activity
TGAM_1402	COG1979	alcohol dehydrogenase
TGAM_1404	COG0483	inositol monophosphate 1-phosphatase activity
TGAM_1406	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TGAM_1408	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TGAM_1412	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TGAM_1414	COG1446	asparaginase
TGAM_1416	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TGAM_1416	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TGAM_1425	COG2205	protein histidine kinase activity
TGAM_1430	COG1469	GTP cyclohydrolase I activity
TGAM_1432	COG1160	GTP binding
TGAM_1435	COG0725	ABC transporter, periplasmic molybdate-binding protein
TGAM_1436	COG4149	molybdate abc transporter
TGAM_1437	COG3842	ATPase activity
TGAM_1440	COG0521	Mo-molybdopterin cofactor biosynthetic process
TGAM_1442	COG0252	asparaginase activity
TGAM_1444	COG1695	Transcriptional regulator
TGAM_1449	COG0011	TIGRFAM Protein of
TGAM_1450	COG2078	PFAM AMMECR1 domain protein
TGAM_1451	COG1136	(ABC) transporter
TGAM_1454	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TGAM_1454	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TGAM_1455	COG0417	DNA replication proofreading
TGAM_1460	COG1185	polyribonucleotide nucleotidyltransferase activity
TGAM_1479	COG3473	Maleate cis-trans isomerase
TGAM_1481	COG0301	tRNA thio-modification
TGAM_1484	COG0301	tRNA thio-modification
TGAM_1487	COG1131	(ABC) transporter
TGAM_1493	COG0359	binds to the 23S rRNA
TGAM_1493	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
TGAM_1499	COG0463	Glycosyl transferase, family 2
TGAM_1500	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TGAM_1513	COG0546	phosphoglycolate phosphatase activity
TGAM_1515	COG0714	Associated with various cellular activities
TGAM_1520	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TGAM_1521	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
TGAM_1529	COG0643	Histidine kinase
TGAM_1529	COG2198	Histidine kinase
TGAM_1530	COG2201	protein-glutamate methylesterase activity
TGAM_1544	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TGAM_1545	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TGAM_1549	COG0215	cysteine-tRNA ligase activity
TGAM_1551	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TGAM_1554	COG0517	IMP dehydrogenase activity
TGAM_1554	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TGAM_1556	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TGAM_1557	COG2379	hydroxypyruvate reductase
TGAM_1559	COG3842	ATPase activity
TGAM_1565	COG0463	Glycosyl transferase, family 2
TGAM_1573	COG2814	Major facilitator Superfamily
TGAM_1574	COG1201	RNA secondary structure unwinding
TGAM_1577	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TGAM_1578	COG0456	acetyltransferase
TGAM_1590	COG0436	Aminotransferase
TGAM_1591	COG0287	Prephenate dehydrogenase
TGAM_1591	COG1605	Chorismate mutase
TGAM_1593	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TGAM_1594	COG0083	homoserine kinase activity
TGAM_1595	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TGAM_1596	COG0710	3-dehydroquinate dehydratase activity
TGAM_1597	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TGAM_1598	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TGAM_1599	COG3958	Transketolase
TGAM_1600	COG3959	Transketolase, thiamine diphosphate binding domain
TGAM_1607	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TGAM_1609	COG0131	Imidazoleglycerol-phosphate dehydratase
TGAM_1610	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TGAM_1611	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TGAM_1612	COG0107	imidazoleglycerol-phosphate synthase activity
TGAM_1613	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TGAM_1613	COG0140	phosphoribosyl-ATP diphosphatase activity
TGAM_1614	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TGAM_1616	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TGAM_1623	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TGAM_1630	COG0210	DNA helicase
TGAM_1633	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TGAM_1635	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TGAM_1640	COG1744	ABC transporter substrate-binding protein PnrA-like
TGAM_1651	COG0628	permease
TGAM_1655	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
TGAM_1656	COG1131	(ABC) transporter
TGAM_1658	COG0556	nucleotide-excision repair
TGAM_1659	COG0101	tRNA pseudouridine synthase activity
TGAM_1660	COG0463	Glycosyl transferase, family 2
TGAM_1661	COG0504	CTP synthase activity
TGAM_1664	COG1881	PFAM PEBP family protein
TGAM_1666	COG1872	DUF167
TGAM_1668	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TGAM_1672	COG1993	acr, cog1993
TGAM_1673	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TGAM_1675	COG0010	Belongs to the arginase family
TGAM_1679	COG1110	DNA topoisomerase II activity
TGAM_1688	COG0071	Belongs to the small heat shock protein (HSP20) family
TGAM_1689	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TGAM_1693	COG0584	glycerophosphoryl diester phosphodiesterase
TGAM_1695	COG2211	Major facilitator Superfamily
TGAM_1697	COG0429	hydrolase of the alpha beta-hydrolase fold
TGAM_1699	COG1131	(ABC) transporter
TGAM_1700	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TGAM_1701	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TGAM_1704	COG4208	sulfate ABC transporter
TGAM_1705	COG3842	ATPase activity
TGAM_1706	COG4143	(ABC) transporter
TGAM_1707	COG0733	neurotransmitter:sodium symporter activity
TGAM_1710	COG0347	Belongs to the P(II) protein family
TGAM_1711	COG1543	Belongs to the glycosyl hydrolase 57 family
TGAM_1715	COG1757	Na H antiporter
TGAM_1720	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TGAM_1721	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TGAM_1722	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TGAM_1725	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
TGAM_1726	COG1355	regulation of microtubule-based process
TGAM_1731	COG1058	Belongs to the CinA family
TGAM_1731	COG1546	Belongs to the CinA family
TGAM_1732	COG2414	aldehyde ferredoxin oxidoreductase
TGAM_1734	COG0475	glutathione-regulated potassium exporter activity
TGAM_1736	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TGAM_1737	COG0423	glycine-tRNA ligase activity
TGAM_1742	COG0419	ATPase involved in DNA repair
TGAM_1742	COG0419	ATPase involved in DNA repair
TGAM_1749	COG3291	Pkd domain containing protein
TGAM_1754	COG1830	Aldolase
TGAM_1755	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
TGAM_1755	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
TGAM_1756	COG1301	dicarboxylic acid transport
TGAM_1766	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TGAM_1767	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TGAM_1769	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TGAM_1772	COG0058	SHG alpha-glucan phosphorylase activity
TGAM_1775	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TGAM_1781	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TGAM_1783	COG2894	cell division
TGAM_1786	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
TGAM_1791	COG0579	oxidoreductase
TGAM_1802	COG1122	ATPase activity
TGAM_1804	COG1268	BioY protein
TGAM_1807	COG0527	aspartate kinase activity
TGAM_1808	COG0083	homoserine kinase activity
TGAM_1809	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TGAM_1810	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TGAM_1811	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
TGAM_1814	COG1573	uracil-dna glycosylase
TGAM_1816	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TGAM_1820	COG1346	cytolysis
TGAM_1822	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TGAM_1823	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TGAM_1824	COG1525	nuclease
TGAM_1826	COG1304	FMN binding
TGAM_1828	COG0142	geranyltranstransferase activity
TGAM_1832	COG0495	leucyl-tRNA aminoacylation
TGAM_1834	COG0006	proline dipeptidase activity
TGAM_1837	COG2119	membrane
TGAM_1841	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TGAM_1842	COG1192	Involved in chromosome partitioning
TGAM_1844	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TGAM_1844	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TGAM_1846	COG0284	orotidine-5'-phosphate decarboxylase activity
TGAM_1850	COG1175	transmembrane transport
TGAM_1851	COG3833	ABC-type maltose transport systems, permease component
TGAM_1852	COG3842	ATPase activity
TGAM_1853	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TGAM_1853	COG1213	nucleotidyl transferase
TGAM_1855	COG0531	amino acid
TGAM_1858	COG1131	(ABC) transporter
TGAM_1867	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TGAM_1868	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TGAM_1871	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TGAM_1873	COG0105	UTP biosynthetic process
TGAM_1877	COG0585	pseudouridine synthase activity
TGAM_1880	COG0017	Asparaginyl-tRNA synthetase
TGAM_1882	COG1418	mRNA catabolic process
TGAM_1889	COG0546	phosphoglycolate phosphatase activity
TGAM_1897	COG1522	sequence-specific DNA binding
TGAM_1898	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TGAM_1900	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TGAM_1901	COG0330	HflC and HflK could
TGAM_1902	COG0616	signal peptide processing
TGAM_1910	COG0513	Belongs to the DEAD box helicase family
TGAM_1913	COG2414	aldehyde ferredoxin oxidoreductase
TGAM_1920	COG0049	tRNA binding
TGAM_1924	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TGAM_1925	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TGAM_1926	COG0085	RNA polymerase activity
TGAM_1931	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TGAM_1931	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TGAM_1932	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TGAM_1933	COG0424	maF-like protein
TGAM_1935	COG4956	integral membrane protein (PIN domain superfamily)
TGAM_1936	COG2894	cell division
TGAM_1938	COG0367	asparagine synthase
TGAM_1940	COG0009	L-threonylcarbamoyladenylate synthase
TGAM_1943	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TGAM_1944	COG0303	'Molybdopterin
TGAM_1945	COG1522	sequence-specific DNA binding
TGAM_1947	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TGAM_1950	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TGAM_1953	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TGAM_1959	COG0052	Belongs to the universal ribosomal protein uS2 family
TGAM_1960	COG0148	phosphopyruvate hydratase activity
TGAM_1963	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TGAM_1964	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TGAM_1968	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TGAM_1969	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TGAM_1970	COG2813	Specifically methylates the guanine in position
TGAM_1972	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TGAM_1975	COG1102	Psort location Cytoplasmic, score
TGAM_1980	COG0200	Binds to the 23S rRNA
TGAM_1981	COG1841	ribosomal large subunit assembly
TGAM_1982	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TGAM_1983	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TGAM_1986	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TGAM_1987	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TGAM_1989	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TGAM_1991	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TGAM_1992	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TGAM_1993	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TGAM_1995	COG0023	Translation Initiation Factor
TGAM_1996	COG0255	Belongs to the universal ribosomal protein uL29 family
TGAM_1997	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TGAM_1998	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TGAM_1999	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TGAM_2000	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TGAM_2001	COG0089	rRNA binding
TGAM_2003	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TGAM_2012	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TGAM_2015	COG0017	Asparaginyl-tRNA synthetase
TGAM_2018	COG1487	ribonuclease activity
TGAM_2020	COG0430	RNA-3'-phosphate cyclase activity
TGAM_2024	COG1372	Participates in initiation and elongation during chromosome replication
TGAM_2024	COG0305	Participates in initiation and elongation during chromosome replication
TGAM_2026	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TGAM_2028	COG5016	pyruvate
TGAM_2028	COG0511	ligase activity, forming carbon-carbon bonds
TGAM_2029	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
TGAM_2030	COG0517	IMP dehydrogenase activity
TGAM_2030	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TGAM_2031	COG0460	homoserine dehydrogenase
TGAM_2035	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TGAM_2036	COG1185	polyribonucleotide nucleotidyltransferase activity
TGAM_2039	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TGAM_2044	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
TGAM_2049	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TGAM_2052	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TGAM_2053	COG1120	ATPase activity
TGAM_2054	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TGAM_2055	COG0456	acetyltransferase
TGAM_2060	COG0156	8-amino-7-oxononanoate synthase activity
TGAM_2062	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TGAM_2065	COG2361	Protein of unknown function DUF86
TGAM_2068	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TGAM_2070	COG3557	Belongs to the UPF0374 family
TGAM_2074	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TGAM_2075	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TGAM_2077	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TGAM_2079	COG3885	ferrous iron binding
TGAM_2079	COG2078	PFAM AMMECR1 domain protein
TGAM_2080	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TGAM_2088	COG0540	Belongs to the ATCase OTCase family
TGAM_2089	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
TGAM_2095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TGAM_2099	COG0434	BtpA family
TGAM_2106	COG0312	modulator of DNA gyrase
TGAM_2109	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TGAM_2113	COG2226	methyltransferase
TGAM_2128	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TGAM_2130	COG0037	tRNA processing
TGAM_2132	COG1449	Belongs to the glycosyl hydrolase 57 family
TGAM_2139	COG2244	polysaccharide biosynthetic process
TGAM_2142	COG0438	transferase activity, transferring glycosyl groups
TGAM_2142	COG0297	glycogen (starch) synthase activity
TGAM_2146	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TGAM_2147	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TGAM_2148	COG1216	Glycosyl transferase, family 2
TGAM_2151	COG0673	inositol 2-dehydrogenase activity
TGAM_2153	COG0463	Glycosyl transferase, family 2
TGAM_2155	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TGAM_2156	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TGAM_2157	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TGAM_2157	COG1796	DNA polymerase