locus-tag	class	description
A3K92_00015	COG1216	Glycosyl transferase, family 2
A3K92_00015	COG0463	Glycosyl transferase, family 2
A3K92_00030	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A3K92_00040	COG0475	glutathione-regulated potassium exporter activity
A3K92_00060	COG1449	Belongs to the glycosyl hydrolase 57 family
A3K92_00070	COG0037	tRNA processing
A3K92_00080	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A3K92_00120	COG0312	modulator of DNA gyrase
A3K92_00125	COG0312	modulator of DNA gyrase
A3K92_00135	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A3K92_00155	COG0434	BtpA family
A3K92_00165	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A3K92_00195	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
A3K92_00200	COG0540	Belongs to the ATCase OTCase family
A3K92_00235	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A3K92_00240	COG3885	ferrous iron binding
A3K92_00240	COG2078	PFAM AMMECR1 domain protein
A3K92_00255	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A3K92_00260	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A3K92_00295	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A3K92_00315	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A3K92_00325	COG0156	8-amino-7-oxononanoate synthase activity
A3K92_00340	COG0456	acetyltransferase
A3K92_00345	COG0433	COG0433 Predicted ATPase
A3K92_00350	COG0420	3'-5' exonuclease activity
A3K92_00355	COG0419	ATPase involved in DNA repair
A3K92_00355	COG0419	ATPase involved in DNA repair
A3K92_00365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A3K92_00370	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A3K92_00375	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A3K92_00430	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
A3K92_00435	COG2226	methyltransferase
A3K92_00475	COG1185	polyribonucleotide nucleotidyltransferase activity
A3K92_00480	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A3K92_00510	COG0517	IMP dehydrogenase activity
A3K92_00510	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A3K92_00515	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
A3K92_00520	COG5016	pyruvate
A3K92_00520	COG0511	ligase activity, forming carbon-carbon bonds
A3K92_00530	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A3K92_00565	COG0430	RNA-3'-phosphate cyclase activity
A3K92_00595	COG0017	Asparaginyl-tRNA synthetase
A3K92_00605	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A3K92_00645	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A3K92_00655	COG0089	rRNA binding
A3K92_00660	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A3K92_00665	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A3K92_00675	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A3K92_00680	COG0255	Belongs to the universal ribosomal protein uL29 family
A3K92_00685	COG0023	Translation Initiation Factor
A3K92_00695	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A3K92_00700	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A3K92_00705	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A3K92_00715	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A3K92_00725	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A3K92_00730	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A3K92_00745	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A3K92_00755	COG1841	ribosomal large subunit assembly
A3K92_00760	COG0200	Binds to the 23S rRNA
A3K92_00785	COG1102	Psort location Cytoplasmic, score
A3K92_00795	COG1028	Short-chain dehydrogenase reductase Sdr
A3K92_00800	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A3K92_00815	COG2813	Specifically methylates the guanine in position
A3K92_00825	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A3K92_00830	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A3K92_00855	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A3K92_00860	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A3K92_00885	COG0052	Belongs to the universal ribosomal protein uS2 family
A3K92_00900	COG1695	Transcriptional regulator
A3K92_00920	COG0366	Alpha amylase catalytic
A3K92_00955	COG0424	maF-like protein
A3K92_00970	COG2894	cell division
A3K92_00980	COG0367	asparagine synthase
A3K92_00990	COG0009	L-threonylcarbamoyladenylate synthase
A3K92_01010	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A3K92_01015	COG0303	'Molybdopterin
A3K92_01025	COG1522	sequence-specific DNA binding
A3K92_01035	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A3K92_01050	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A3K92_01065	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A3K92_01070	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A3K92_01085	COG0085	RNA polymerase activity
A3K92_01090	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A3K92_01095	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A3K92_01115	COG0049	tRNA binding
A3K92_01125	COG1487	ribonuclease activity
A3K92_01135	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A3K92_01145	COG2414	aldehyde ferredoxin oxidoreductase
A3K92_01170	COG0513	Belongs to the DEAD box helicase family
A3K92_01210	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A3K92_01215	COG0058	SHG alpha-glucan phosphorylase activity
A3K92_01230	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A3K92_01260	COG2894	cell division
A3K92_01270	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A3K92_01320	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A3K92_01335	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A3K92_01340	COG1522	sequence-specific DNA binding
A3K92_01350	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
A3K92_01355	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A3K92_01360	COG1355	regulation of microtubule-based process
A3K92_01370	COG2361	Protein of unknown function DUF86
A3K92_01385	COG1546	Belongs to the CinA family
A3K92_01385	COG1058	Belongs to the CinA family
A3K92_01410	COG1304	FMN binding
A3K92_01435	COG0495	leucyl-tRNA aminoacylation
A3K92_01445	COG0006	proline dipeptidase activity
A3K92_01505	COG0071	Belongs to the small heat shock protein (HSP20) family
A3K92_01555	COG1110	DNA topoisomerase II activity
A3K92_01595	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A3K92_01610	COG1346	cytolysis
A3K92_01615	COG1380	Effector of murein hydrolase LrgA
A3K92_01630	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A3K92_01640	COG1573	uracil-dna glycosylase
A3K92_01645	COG1757	Na H antiporter
A3K92_01670	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
A3K92_01715	COG0579	oxidoreductase
A3K92_01720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A3K92_01745	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A3K92_01750	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
A3K92_01775	COG1418	mRNA catabolic process
A3K92_01785	COG0017	Asparaginyl-tRNA synthetase
A3K92_01800	COG0585	pseudouridine synthase activity
A3K92_01825	COG0105	UTP biosynthetic process
A3K92_01830	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A3K92_01855	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A3K92_01915	COG1213	nucleotidyl transferase
A3K92_01915	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A3K92_01935	COG0084	hydrolase, TatD family'
A3K92_01950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A3K92_01970	COG1401	restriction endodeoxyribonuclease activity
A3K92_02045	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A3K92_02090	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A3K92_02095	COG1192	Involved in chromosome partitioning
A3K92_02105	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A3K92_02105	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A3K92_02115	COG0284	orotidine-5'-phosphate decarboxylase activity
A3K92_02130	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A3K92_02150	COG1872	DUF167
A3K92_02170	COG2361	Protein of unknown function DUF86
A3K92_02175	COG0423	glycine-tRNA ligase activity
A3K92_02205	COG1993	acr, cog1993
A3K92_02210	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A3K92_02225	COG1042	CoA-binding domain protein
A3K92_02225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A3K92_02225	COG0045	succinate-CoA ligase (ADP-forming) activity
A3K92_02285	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A3K92_02305	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A3K92_02315	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A3K92_02330	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A3K92_02335	COG1984	allophanate hydrolase subunit 2
A3K92_02365	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
A3K92_02375	COG1196	nuclear chromosome segregation
A3K92_02395	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A3K92_02430	COG1056	cytidyltransferase-related domain
A3K92_02430	COG1051	belongs to the nudix hydrolase family
A3K92_02470	COG1132	(ABC) transporter
A3K92_02475	COG1132	(ABC) transporter
A3K92_02510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A3K92_02510	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A3K92_02520	COG0778	Nitroreductase
A3K92_02535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A3K92_02540	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
A3K92_02545	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A3K92_02575	COG1543	Belongs to the glycosyl hydrolase 57 family
A3K92_02580	COG0347	Belongs to the P(II) protein family
A3K92_02590	COG0733	neurotransmitter:sodium symporter activity
A3K92_02595	COG4143	(ABC) transporter
A3K92_02600	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A3K92_02605	COG1178	ABC-type Fe3 transport system permease component
A3K92_02625	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A3K92_02630	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A3K92_02645	COG2211	Major facilitator Superfamily
A3K92_02650	COG0584	glycerophosphoryl diester phosphodiesterase
A3K92_02655	COG0584	glycerophosphoryl diester phosphodiesterase
A3K92_02670	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
A3K92_02700	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A3K92_02705	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A3K92_02725	COG0215	cysteine-tRNA ligase activity
A3K92_02735	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A3K92_02745	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
A3K92_02755	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A3K92_02765	COG0456	acetyltransferase
A3K92_02780	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A3K92_02800	COG2192	nodulation
A3K92_02805	COG0442	prolyl-tRNA aminoacylation
A3K92_02810	COG0446	pyridine nucleotide-disulphide oxidoreductase
A3K92_02845	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A3K92_02845	COG0574	Belongs to the PEP-utilizing enzyme family
A3K92_02850	COG0534	Mate efflux family protein
A3K92_02855	COG0534	Mate efflux family protein
A3K92_02860	COG1505	serine-type exopeptidase activity
A3K92_02875	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A3K92_02885	COG0735	belongs to the Fur family
A3K92_02920	COG0671	phosphoesterase, PA-phosphatase related
A3K92_02930	COG0243	molybdopterin cofactor binding
A3K92_02945	COG0312	modulator of DNA gyrase
A3K92_02955	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
A3K92_02965	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A3K92_02990	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A3K92_02990	COG0674	pyruvate-flavodoxin oxidoreductase activity
A3K92_02995	COG1013	pyruvate-flavodoxin oxidoreductase activity
A3K92_03005	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A3K92_03005	COG0674	pyruvate-flavodoxin oxidoreductase activity
A3K92_03010	COG1013	pyruvate-flavodoxin oxidoreductase activity
A3K92_03030	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A3K92_03030	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A3K92_03035	COG0307	riboflavin synthase, alpha
A3K92_03050	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A3K92_03065	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A3K92_03070	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A3K92_03080	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A3K92_03120	COG0552	protein localization to endoplasmic reticulum
A3K92_03120	COG0457	Tetratricopeptide repeat
A3K92_03130	COG0477	Major facilitator Superfamily
A3K92_03135	COG1201	RNA secondary structure unwinding
A3K92_03145	COG2403	cyclic 2,3-diphosphoglycerate synthetase activity
A3K92_03155	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A3K92_03160	COG0517	IMP dehydrogenase activity
A3K92_03160	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A3K92_03190	COG1129	ABC transporter
A3K92_03200	COG0598	Magnesium transport protein CorA
A3K92_03220	COG0504	CTP synthase activity
A3K92_03230	COG1199	ATP-dependent helicase activity
A3K92_03265	COG0432	Pfam Uncharacterised protein family UPF0047
A3K92_03295	COG1832	CoA-binding protein
A3K92_03320	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A3K92_03375	COG0517	IMP dehydrogenase activity
A3K92_03375	COG0516	GMP reductase activity
A3K92_03385	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
A3K92_03395	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
A3K92_03435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A3K92_03440	COG0656	L-ascorbic acid biosynthetic process
A3K92_03475	COG0045	succinate-CoA ligase (ADP-forming) activity
A3K92_03475	COG1042	CoA-binding domain protein
A3K92_03475	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A3K92_03495	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A3K92_03510	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A3K92_03515	COG2095	MarC family integral membrane protein
A3K92_03520	COG1765	OsmC-like protein
A3K92_03530	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A3K92_03535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A3K92_03560	COG0051	transcription antitermination factor activity, RNA binding
A3K92_03585	COG1335	isochorismatase
A3K92_03610	COG1739	Uncharacterized protein family UPF0029
A3K92_03615	COG1111	helicase
A3K92_03615	COG1205	dead DEAH box helicase
A3K92_03645	COG2382	esterase
A3K92_03650	COG0315	cyclic pyranopterin monophosphate synthase activity
A3K92_03665	COG0301	tRNA thio-modification
A3K92_03690	COG0359	binds to the 23S rRNA
A3K92_03690	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
A3K92_03725	COG0601	transmembrane transport
A3K92_03730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A3K92_03735	COG0444	Belongs to the ABC transporter superfamily
A3K92_03740	COG4608	Belongs to the ABC transporter superfamily
A3K92_03745	COG2723	6-phospho-beta-galactosidase activity
A3K92_03755	COG4221	oxidoreductase activity
A3K92_03780	COG2723	6-phospho-beta-galactosidase activity
A3K92_03795	COG1216	Glycosyl transferase, family 2
A3K92_03800	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A3K92_03820	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A3K92_03820	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
A3K92_03835	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A3K92_03835	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A3K92_03845	COG0720	synthase
A3K92_03860	COG1592	Rubrerythrin
A3K92_03865	COG1773	rubredoxin
A3K92_03870	COG2033	superoxide reductase activity
A3K92_03910	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A3K92_03930	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A3K92_03970	COG1363	Peptidase, m42
A3K92_04000	COG2096	Adenosyltransferase
A3K92_04005	COG1794	racemase activity, acting on amino acids and derivatives
A3K92_04015	COG0463	Glycosyl transferase, family 2
A3K92_04025	COG0101	tRNA pseudouridine synthase activity
A3K92_04030	COG0556	nucleotide-excision repair
A3K92_04040	COG1131	(ABC) transporter
A3K92_04080	COG0628	permease
A3K92_04100	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A3K92_04105	COG2271	Major facilitator Superfamily
A3K92_04110	COG0515	serine threonine protein kinase
A3K92_04120	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A3K92_04130	COG1446	asparaginase
A3K92_04145	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A3K92_04145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A3K92_04190	COG2205	protein histidine kinase activity
A3K92_04210	COG1469	GTP cyclohydrolase I activity
A3K92_04215	COG1078	dGTPase activity
A3K92_04220	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A3K92_04225	COG0417	DNA replication proofreading
A3K92_04245	COG2078	PFAM AMMECR1 domain protein
A3K92_04250	COG0011	TIGRFAM Protein of
A3K92_04285	COG1131	(ABC) transporter
A3K92_04295	COG1695	Transcriptional regulator
A3K92_04305	COG0252	asparaginase activity
A3K92_04320	COG0303	'Molybdopterin
A3K92_04330	COG3842	ATPase activity
A3K92_04335	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
A3K92_04340	COG0725	ABC transporter, periplasmic molybdate-binding protein
A3K92_04385	COG0543	2 iron, 2 sulfur cluster binding
A3K92_04390	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A3K92_04390	COG0493	'glutamate synthase
A3K92_04405	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A3K92_04420	COG0509	glycine decarboxylation via glycine cleavage system
A3K92_04425	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A3K92_04475	COG1515	deoxyribonuclease V activity
A3K92_04485	COG0252	asparaginase activity
A3K92_04490	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A3K92_04495	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A3K92_04495	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A3K92_04500	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A3K92_04520	COG1230	cation diffusion facilitator family transporter
A3K92_04540	COG1301	dicarboxylic acid transport
A3K92_04580	COG0668	transmembrane transport
A3K92_04590	COG4145	pantothenate transmembrane transporter activity
A3K92_04600	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A3K92_04625	COG1881	PFAM PEBP family protein
A3K92_04630	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A3K92_04655	COG0823	Involved in the tonB-independent uptake of proteins
A3K92_04655	COG1506	peptidase
A3K92_04655	COG4946	Tricorn protease homolog
A3K92_04665	COG1444	tRNA N-acetyltransferase activity
A3K92_04680	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A3K92_04685	COG2050	protein possibly involved in aromatic compounds catabolism
A3K92_04685	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A3K92_04690	COG0436	Aminotransferase
A3K92_04735	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A3K92_04755	COG1078	dGTPase activity
A3K92_04765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A3K92_04785	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A3K92_04805	COG2189	Belongs to the N(4) N(6)-methyltransferase family
A3K92_04815	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A3K92_04895	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A3K92_04905	COG0546	phosphoglycolate phosphatase activity
A3K92_04955	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A3K92_04965	COG0483	inositol monophosphate 1-phosphatase activity
A3K92_04975	COG1979	alcohol dehydrogenase
A3K92_04985	COG1160	GTP binding
A3K92_05005	COG1131	(ABC) transporter
A3K92_05015	COG1476	TRANSCRIPTIONal
A3K92_05050	COG1013	pyruvate-flavodoxin oxidoreductase activity
A3K92_05065	COG1185	polyribonucleotide nucleotidyltransferase activity
A3K92_05095	COG0778	Nitroreductase
A3K92_05105	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A3K92_05110	COG0534	Mate efflux family protein
A3K92_05130	COG1830	Aldolase
A3K92_05135	COG1301	dicarboxylic acid transport
A3K92_05140	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A3K92_05140	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A3K92_05150	COG0525	valine-tRNA ligase activity
A3K92_05185	COG1695	Transcriptional regulator
A3K92_05195	COG0393	Putative heavy-metal-binding
A3K92_05265	COG2414	aldehyde ferredoxin oxidoreductase
A3K92_05270	COG2104	thiamine diphosphate biosynthetic process
A3K92_05275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A3K92_05285	COG0018	arginyl-trna synthetase
A3K92_05305	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A3K92_05315	COG1863	multisubunit Na H antiporter MnhE subunit
A3K92_05325	COG1320	monovalent cation:proton antiporter activity
A3K92_05335	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A3K92_05335	COG2111	Na H antiporter
A3K92_05340	COG1006	Multisubunit Na H antiporter MnhC subunit
A3K92_05345	COG0651	ATP synthesis coupled electron transport
A3K92_05350	COG0651	ATP synthesis coupled electron transport
A3K92_05360	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A3K92_05365	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A3K92_05370	COG0649	NAD binding
A3K92_05395	COG1388	LysM domain
A3K92_05395	COG2373	Large extracellular alpha-helical protein
A3K92_05395	COG4932	domain protein
A3K92_05410	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A3K92_05435	COG2894	cell division
A3K92_05440	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A3K92_05445	COG1063	alcohol dehydrogenase
A3K92_05460	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A3K92_05470	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
A3K92_05475	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A3K92_05480	COG1899	peptidyl-lysine modification to peptidyl-hypusine
A3K92_05485	COG0493	'glutamate synthase
A3K92_05490	COG1028	Short-chain dehydrogenase reductase Sdr
A3K92_05495	COG0501	Belongs to the peptidase M48B family
A3K92_05505	COG0459	protein refolding
A3K92_05510	COG0515	serine threonine protein kinase
A3K92_05525	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A3K92_05530	COG0668	transmembrane transport
A3K92_05580	COG0560	Phosphoserine phosphatase
A3K92_05595	COG2234	aminopeptidase activity
A3K92_05610	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A3K92_05625	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A3K92_05640	COG2814	Major facilitator Superfamily
A3K92_05660	COG0420	3'-5' exonuclease activity
A3K92_05670	COG1396	sequence-specific DNA binding
A3K92_05680	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A3K92_05690	COG2267	carboxylic ester hydrolase activity
A3K92_05710	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A3K92_05725	COG1489	DNA binding
A3K92_05750	COG1185	polyribonucleotide nucleotidyltransferase activity
A3K92_05765	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A3K92_05800	COG0402	S-adenosylhomocysteine deaminase activity
A3K92_05805	COG0017	Asparaginyl-tRNA synthetase
A3K92_05825	COG0436	Aminotransferase
A3K92_05840	COG2140	Oxalate decarboxylase
A3K92_05845	COG1994	Peptidase M50
A3K92_05860	COG1234	tRNA 3'-trailer cleavage
A3K92_05875	COG1121	(ABC) transporter
A3K92_05885	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A3K92_05905	COG0006	proline dipeptidase activity
A3K92_05920	COG0482	sulfurtransferase activity
A3K92_05935	COG1918	ferrous iron import across plasma membrane
A3K92_05935	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A3K92_05945	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A3K92_05955	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
A3K92_05965	COG0163	prenyltransferase activity
A3K92_05970	COG1522	sequence-specific DNA binding
A3K92_05980	COG0012	GTP binding
A3K92_05990	COG1794	racemase activity, acting on amino acids and derivatives
A3K92_06020	COG0312	modulator of DNA gyrase
A3K92_06030	COG2264	protein methyltransferase activity
A3K92_06045	COG0501	Belongs to the peptidase M48B family
A3K92_06050	COG2131	deaminase
A3K92_06060	COG0546	phosphoglycolate phosphatase activity
A3K92_06065	COG1522	sequence-specific DNA binding
A3K92_06075	COG0693	protein deglycase activity
A3K92_06080	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A3K92_06080	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A3K92_06085	COG2264	protein methyltransferase activity
A3K92_06105	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A3K92_06110	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A3K92_06150	COG1178	ABC-type Fe3 transport system permease component
A3K92_06155	COG3842	ATPase activity
A3K92_06175	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A3K92_06190	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A3K92_06215	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A3K92_06235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A3K92_06245	COG1297	OPT oligopeptide transporter protein
A3K92_06250	COG1234	tRNA 3'-trailer cleavage
A3K92_06255	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A3K92_06265	COG3842	ATPase activity
A3K92_06275	COG3833	ABC-type maltose transport systems, permease component
A3K92_06280	COG1175	transmembrane transport
A3K92_06295	COG1378	Sugar-specific transcriptional regulator TrmB
A3K92_06300	COG1653	transport
A3K92_06305	COG1175	transmembrane transport
A3K92_06310	COG0395	ABC-type sugar transport system, permease component
A3K92_06315	COG0438	transferase activity, transferring glycosyl groups
A3K92_06325	COG0297	glycogen (starch) synthase activity
A3K92_06335	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A3K92_06380	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A3K92_06385	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
A3K92_06405	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A3K92_06430	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
A3K92_06435	COG1201	RNA secondary structure unwinding
A3K92_06455	COG1342	Belongs to the UPF0251 family
A3K92_06460	COG0455	bacterial-type flagellum organization
A3K92_06465	COG0489	protein tyrosine kinase activity
A3K92_06495	COG2226	methyltransferase
A3K92_06500	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A3K92_06500	COG0731	radical SAM domain protein
A3K92_06515	COG2226	methyltransferase
A3K92_06520	COG0719	Fe-S assembly protein
A3K92_06525	COG0396	ATPase activity
A3K92_06550	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
A3K92_06560	COG0732	type I restriction modification DNA specificity domain
A3K92_06580	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A3K92_06590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A3K92_06600	COG0730	response to heat
A3K92_06605	COG0730	response to heat
A3K92_06615	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A3K92_06620	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
A3K92_06625	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
A3K92_06630	COG1851	Uncharacterised protein family (UPF0128)
A3K92_06685	COG0519	Catalyzes the synthesis of GMP from XMP
A3K92_06685	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A3K92_06700	COG0519	Catalyzes the synthesis of GMP from XMP
A3K92_06700	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A3K92_06745	COG0517	IMP dehydrogenase activity
A3K92_06745	COG0516	GMP reductase activity
A3K92_06755	COG0175	sulfate reduction
A3K92_06760	COG0330	HflC and HflK could
A3K92_06770	COG1435	thymidine kinase activity
A3K92_06785	COG2890	protein-(glutamine-N5) methyltransferase activity
A3K92_06885	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A3K92_06900	COG0167	dihydroorotate dehydrogenase activity
A3K92_06925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A3K92_06955	COG2151	metal-sulfur cluster biosynthetic enzyme
A3K92_06960	COG1141	Ferredoxin
A3K92_06980	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A3K92_06980	COG0493	'glutamate synthase
A3K92_06985	COG0543	2 iron, 2 sulfur cluster binding
A3K92_07015	COG1850	ribulose-bisphosphate carboxylase activity
A3K92_07040	COG2252	PERMEase
A3K92_07070	COG1522	sequence-specific DNA binding
A3K92_07075	COG1836	PFAM Integral membrane protein DUF92
A3K92_07080	COG0301	tRNA thio-modification
A3K92_07080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A3K92_07110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A3K92_07130	COG0456	acetyltransferase
A3K92_07175	COG0726	polysaccharide deacetylase
A3K92_07180	COG0438	transferase activity, transferring glycosyl groups
A3K92_07190	COG1694	Mazg nucleotide pyrophosphohydrolase
A3K92_07200	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A3K92_07220	COG0475	glutathione-regulated potassium exporter activity
A3K92_07230	COG0010	Belongs to the arginase family
A3K92_07270	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A3K92_07280	COG2046	Belongs to the sulfate adenylyltransferase family
A3K92_07300	COG0730	response to heat
A3K92_07335	COG0463	Glycosyl transferase, family 2
A3K92_07360	COG0297	glycogen (starch) synthase activity
A3K92_07360	COG0438	transferase activity, transferring glycosyl groups
A3K92_07395	COG1216	Glycosyl transferase, family 2
A3K92_07410	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A3K92_07425	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A3K92_07435	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
A3K92_07455	COG0697	spore germination
A3K92_07500	COG0589	response to stress
A3K92_07505	COG1628	Protein of unknown function DUF99
A3K92_07515	COG1254	Belongs to the acylphosphatase family
A3K92_07555	COG0174	glutamine synthetase
A3K92_07575	COG4608	Belongs to the ABC transporter superfamily
A3K92_07580	COG0444	Belongs to the ABC transporter superfamily
A3K92_07585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A3K92_07590	COG0601	transmembrane transport
A3K92_07605	COG0543	2 iron, 2 sulfur cluster binding
A3K92_07625	COG0475	glutathione-regulated potassium exporter activity
A3K92_07640	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A3K92_07645	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
A3K92_07655	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A3K92_07665	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A3K92_07670	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A3K92_07700	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A3K92_07715	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A3K92_07720	COG0081	regulation of translation
A3K92_07735	COG0717	Belongs to the dCTP deaminase family
A3K92_07770	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A3K92_07815	COG0124	histidyl-tRNA synthetase
A3K92_07820	COG2095	MarC family integral membrane protein
A3K92_07825	COG0475	glutathione-regulated potassium exporter activity
A3K92_07830	COG0475	glutathione-regulated potassium exporter activity
A3K92_07835	COG0517	IMP dehydrogenase activity
A3K92_07835	COG0516	GMP reductase activity
A3K92_07840	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
A3K92_07855	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A3K92_07855	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
A3K92_07865	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A3K92_07875	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A3K92_07885	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A3K92_07900	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A3K92_07920	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A3K92_07935	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A3K92_07945	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A3K92_07950	COG0306	phosphate transporter
A3K92_07965	COG0674	pyruvate-flavodoxin oxidoreductase activity
A3K92_07970	COG1013	pyruvate-flavodoxin oxidoreductase activity
A3K92_07980	COG0674	pyruvate-flavodoxin oxidoreductase activity
A3K92_07985	COG1013	pyruvate-flavodoxin oxidoreductase activity
A3K92_07995	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A3K92_08015	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
A3K92_08020	COG0409	Hydrogenase expression formation protein
A3K92_08025	COG0298	carbon dioxide binding
A3K92_08035	COG1309	transcriptional regulator
A3K92_08040	COG3383	formate dehydrogenase (NAD+) activity
A3K92_08045	COG0437	4 iron, 4 sulfur cluster binding
A3K92_08050	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A3K92_08050	COG2111	Na H antiporter
A3K92_08055	COG0651	ATP synthesis coupled electron transport
A3K92_08060	COG0650	Formate hydrogenlyase subunit 4
A3K92_08065	COG3261	NADH dehydrogenase
A3K92_08065	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
A3K92_08070	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A3K92_08075	COG3260	NADH ubiquinone oxidoreductase 20
A3K92_08090	COG0746	molybdenum cofactor guanylyltransferase activity
A3K92_08115	COG0489	protein tyrosine kinase activity
A3K92_08125	COG0864	Transcriptional regulator
A3K92_08145	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A3K92_08150	COG0426	domain, Protein
A3K92_08180	COG3842	ATPase activity
A3K92_08195	COG0438	transferase activity, transferring glycosyl groups
A3K92_08200	COG0395	ABC-type sugar transport system, permease component
A3K92_08210	COG1653	transport
A3K92_08215	COG2084	Dehydrogenase
A3K92_08230	COG0778	Nitroreductase
A3K92_08235	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A3K92_08240	COG1028	Short-chain dehydrogenase reductase Sdr
A3K92_08255	COG1528	Iron-storage protein
A3K92_08260	COG0142	geranyltranstransferase activity
A3K92_08265	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A3K92_08275	COG2212	antiporter activity
A3K92_08280	COG1320	monovalent cation:proton antiporter activity
A3K92_08295	COG1006	Multisubunit Na H antiporter MnhC subunit
A3K92_08300	COG1863	multisubunit Na H antiporter MnhE subunit
A3K92_08305	COG0651	ATP synthesis coupled electron transport
A3K92_08310	COG0450	alkyl hydroperoxide reductase
A3K92_08315	COG0489	protein tyrosine kinase activity
A3K92_08335	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A3K92_08335	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A3K92_08345	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A3K92_08345	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A3K92_08365	COG0640	Transcriptional regulator
A3K92_08390	COG0681	Belongs to the peptidase S26 family
A3K92_08395	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
A3K92_08405	COG0235	Class ii aldolase
A3K92_08425	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A3K92_08445	COG0148	phosphopyruvate hydratase activity
A3K92_08465	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A3K92_08500	COG1863	multisubunit Na H antiporter MnhE subunit
A3K92_08505	COG2212	antiporter activity
A3K92_08510	COG1320	monovalent cation:proton antiporter activity
A3K92_08535	COG0651	ATP synthesis coupled electron transport
A3K92_08545	COG3260	NADH ubiquinone oxidoreductase 20
A3K92_08550	COG3261	NADH dehydrogenase
A3K92_08550	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
A3K92_08560	COG0650	Formate hydrogenlyase subunit 4
A3K92_08610	COG1234	tRNA 3'-trailer cleavage
A3K92_08655	COG0179	Fumarylacetoacetate (FAA) hydrolase
A3K92_08665	COG0116	Belongs to the methyltransferase superfamily
A3K92_08665	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A3K92_08705	COG1047	Peptidyl-prolyl cis-trans
A3K92_08730	COG0714	Associated with various cellular activities
A3K92_08750	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
A3K92_08760	COG2442	InterPro IPR007367
A3K92_08780	COG2255	four-way junction helicase activity
A3K92_08795	COG0492	ferredoxin-NADP+ reductase activity
A3K92_08800	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A3K92_08815	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A3K92_08820	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A3K92_08825	COG0314	molybdopterin synthase activity
A3K92_08845	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A3K92_08850	COG1522	sequence-specific DNA binding
A3K92_08865	COG1131	(ABC) transporter
A3K92_08915	COG0601	transmembrane transport
A3K92_08960	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
A3K92_08965	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
A3K92_08975	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
A3K92_08985	COG1269	ATP hydrolysis coupled proton transport
A3K92_08995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A3K92_09005	COG0402	S-adenosylhomocysteine deaminase activity
A3K92_09010	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A3K92_09025	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
A3K92_09120	COG0095	Lipoate-protein ligase
A3K92_09140	COG1980	fructose-bisphosphate aldolase activity
A3K92_09150	COG1233	COG1233 Phytoene dehydrogenase and related
A3K92_09160	COG0306	phosphate transporter
A3K92_09185	COG0823	Involved in the tonB-independent uptake of proteins
A3K92_09185	COG1506	peptidase
A3K92_09185	COG4946	Tricorn protease homolog
A3K92_09230	COG0037	tRNA processing
A3K92_09245	COG0750	zinc metalloprotease
A3K92_09280	COG0714	Associated with various cellular activities
A3K92_09305	COG0463	Glycosyl transferase, family 2
A3K92_09305	COG1216	Glycosyl transferase, family 2
A3K92_09310	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A3K92_09310	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity