locus-tag	class	description
X802_00005	COG1469	GTP cyclohydrolase I activity
X802_00010	COG1160	GTP binding
X802_00045	COG0725	ABC transporter, periplasmic molybdate-binding protein
X802_00050	COG4149	molybdate abc transporter
X802_00055	COG3842	ATPase activity
X802_00070	COG0521	Mo-molybdopterin cofactor biosynthetic process
X802_00080	COG0252	asparaginase activity
X802_00090	COG1695	Transcriptional regulator
X802_00105	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
X802_00150	COG0011	TIGRFAM Protein of
X802_00155	COG2078	PFAM AMMECR1 domain protein
X802_00175	COG1136	(ABC) transporter
X802_00225	COG1185	polyribonucleotide nucleotidyltransferase activity
X802_00250	COG3473	Maleate cis-trans isomerase
X802_00265	COG0301	tRNA thio-modification
X802_00275	COG0301	tRNA thio-modification
X802_00300	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
X802_00300	COG0359	binds to the 23S rRNA
X802_00335	COG0651	ATP synthesis coupled electron transport
X802_00370	COG1863	multisubunit Na H antiporter MnhE subunit
X802_00380	COG1216	Glycosyl transferase, family 2
X802_00385	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
X802_00395	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
X802_00395	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
X802_00415	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
X802_00420	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
X802_00465	COG0643	Histidine kinase
X802_00465	COG2198	Histidine kinase
X802_00470	COG2201	protein-glutamate methylesterase activity
X802_00545	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
X802_00550	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
X802_00570	COG0215	cysteine-tRNA ligase activity
X802_00575	COG0469	pyruvate kinase activity
X802_00580	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
X802_00595	COG0517	IMP dehydrogenase activity
X802_00595	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
X802_00605	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
X802_00620	COG2379	hydroxypyruvate reductase
X802_00630	COG3842	ATPase activity
X802_00635	COG1176	ABC-type spermidine putrescine transport system, permease component I
X802_00655	COG0673	inositol 2-dehydrogenase activity
X802_00660	COG0463	Glycosyl transferase, family 2
X802_00700	COG0477	Major facilitator Superfamily
X802_00710	COG1201	RNA secondary structure unwinding
X802_00745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
X802_00770	COG2226	methyltransferase
X802_00805	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
X802_00830	COG2813	Specifically methylates the guanine in position
X802_00840	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
X802_00840	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
X802_00850	COG0778	Nitroreductase
X802_00860	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
X802_00950	COG3842	ATPase activity
X802_01085	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
X802_01095	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
X802_01125	COG1744	ABC transporter substrate-binding protein PnrA-like
X802_01180	COG0628	permease
X802_01200	COG1131	(ABC) transporter
X802_01210	COG0556	nucleotide-excision repair
X802_01215	COG0101	tRNA pseudouridine synthase activity
X802_01225	COG0463	Glycosyl transferase, family 2
X802_01230	COG0504	CTP synthase activity
X802_01235	COG1881	PFAM PEBP family protein
X802_01250	COG1872	DUF167
X802_01265	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
X802_01285	COG1993	acr, cog1993
X802_01290	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
X802_01310	COG0010	Belongs to the arginase family
X802_01330	COG1110	DNA topoisomerase II activity
X802_01380	COG0071	Belongs to the small heat shock protein (HSP20) family
X802_01400	COG0584	glycerophosphoryl diester phosphodiesterase
X802_01405	COG0584	glycerophosphoryl diester phosphodiesterase
X802_01410	COG2211	Major facilitator Superfamily
X802_01415	COG2271	Major facilitator Superfamily
X802_01420	COG0429	hydrolase of the alpha beta-hydrolase fold
X802_01425	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
X802_01430	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
X802_01440	COG4208	sulfate ABC transporter
X802_01445	COG3842	ATPase activity
X802_01450	COG4143	(ABC) transporter
X802_01455	COG0733	neurotransmitter:sodium symporter activity
X802_01470	COG0347	Belongs to the P(II) protein family
X802_01475	COG1543	Belongs to the glycosyl hydrolase 57 family
X802_01510	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
X802_01515	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
X802_01535	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
X802_01540	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
X802_01545	COG1355	regulation of microtubule-based process
X802_01555	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
X802_01575	COG1546	Belongs to the CinA family
X802_01575	COG1058	Belongs to the CinA family
X802_01580	COG2414	aldehyde ferredoxin oxidoreductase
X802_01590	COG0475	glutathione-regulated potassium exporter activity
X802_01600	COG0423	glycine-tRNA ligase activity
X802_01625	COG0419	ATPase involved in DNA repair
X802_01625	COG0419	ATPase involved in DNA repair
X802_01655	COG1850	ribulose-bisphosphate carboxylase activity
X802_01680	COG0003	Pfam Anion-transporting ATPase
X802_01690	COG1966	Carbon starvation protein
X802_01700	COG1830	Aldolase
X802_01705	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
X802_01705	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
X802_01740	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
X802_01750	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
X802_01755	COG0218	Necessary for normal cell division and for the maintenance of normal septation
X802_01795	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
X802_01800	COG0058	SHG alpha-glucan phosphorylase activity
X802_01815	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
X802_01830	COG0085	RNA polymerase activity
X802_01835	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
X802_01840	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
X802_01860	COG0049	tRNA binding
X802_01885	COG2414	aldehyde ferredoxin oxidoreductase
X802_01930	COG2119	membrane
X802_01950	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
X802_01955	COG1192	Involved in chromosome partitioning
X802_01965	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
X802_01965	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
X802_01975	COG0284	orotidine-5'-phosphate decarboxylase activity
X802_02010	COG1131	(ABC) transporter
X802_02060	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
X802_02065	COG0436	Aminotransferase
X802_02070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
X802_02095	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
X802_02110	COG0105	UTP biosynthetic process
X802_02115	COG1131	(ABC) transporter
X802_02160	COG0585	pseudouridine synthase activity
X802_02175	COG0017	Asparaginyl-tRNA synthetase
X802_02185	COG1418	mRNA catabolic process
X802_02200	COG0546	phosphoglycolate phosphatase activity
X802_02210	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
X802_02220	COG1522	sequence-specific DNA binding
X802_02225	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
X802_02235	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
X802_02290	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
X802_02300	COG2894	cell division
X802_02315	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
X802_02360	COG0579	oxidoreductase
X802_02425	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
X802_02440	COG1757	Na H antiporter
X802_02445	COG1573	uracil-dna glycosylase
X802_02455	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
X802_02470	COG1380	Effector of murein hydrolase LrgA
X802_02475	COG1346	cytolysis
X802_02490	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
X802_02500	COG1304	FMN binding
X802_02510	COG0142	geranyltranstransferase activity
X802_02535	COG1131	(ABC) transporter
X802_02540	COG0495	leucyl-tRNA aminoacylation
X802_02550	COG1574	metal-dependent hydrolase with the TIM-barrel fold
X802_02595	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
X802_02600	COG0424	maF-like protein
X802_02610	COG4956	integral membrane protein (PIN domain superfamily)
X802_02615	COG2894	cell division
X802_02625	COG0367	asparagine synthase
X802_02635	COG0009	L-threonylcarbamoyladenylate synthase
X802_02655	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
X802_02660	COG0303	'Molybdopterin
X802_02670	COG1522	sequence-specific DNA binding
X802_02680	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
X802_02695	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
X802_02715	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
X802_02720	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
X802_02765	COG0052	Belongs to the universal ribosomal protein uS2 family
X802_02770	COG0148	phosphopyruvate hydratase activity
X802_02790	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
X802_02795	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
X802_02830	COG0343	queuine tRNA-ribosyltransferase activity
X802_02870	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
X802_02875	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
X802_02885	COG2813	Specifically methylates the guanine in position
X802_02910	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
X802_02925	COG2723	6-phospho-beta-galactosidase activity
X802_02930	COG4608	Belongs to the ABC transporter superfamily
X802_02935	COG0444	Belongs to the ABC transporter superfamily
X802_02940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
X802_02945	COG0601	transmembrane transport
X802_02950	COG4166	transmembrane transport
X802_02990	COG4221	oxidoreductase activity
X802_03000	COG1102	Psort location Cytoplasmic, score
X802_03025	COG0200	Binds to the 23S rRNA
X802_03030	COG1841	ribosomal large subunit assembly
X802_03035	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
X802_03040	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
X802_03055	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
X802_03060	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
X802_03070	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
X802_03080	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
X802_03085	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
X802_03090	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
X802_03100	COG0023	Translation Initiation Factor
X802_03105	COG0255	Belongs to the universal ribosomal protein uL29 family
X802_03110	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
X802_03120	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
X802_03125	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
X802_03130	COG0089	rRNA binding
X802_03140	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
X802_03165	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
X802_03190	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
X802_03205	COG0017	Asparaginyl-tRNA synthetase
X802_03240	COG0543	2 iron, 2 sulfur cluster binding
X802_03250	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
X802_03285	COG0714	Associated with various cellular activities
X802_03300	COG0430	RNA-3'-phosphate cyclase activity
X802_03330	COG1372	Participates in initiation and elongation during chromosome replication
X802_03330	COG0305	Participates in initiation and elongation during chromosome replication
X802_03340	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
X802_03350	COG0511	ligase activity, forming carbon-carbon bonds
X802_03350	COG5016	pyruvate
X802_03355	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
X802_03365	COG2239	Acts as a magnesium transporter
X802_03390	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
X802_03410	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
X802_03425	COG2814	Major facilitator Superfamily
X802_03440	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
X802_03465	COG1234	tRNA 3'-trailer cleavage
X802_03480	COG0640	Transcriptional regulator
X802_03505	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
X802_03505	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
X802_03520	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
X802_03520	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
X802_03540	COG0489	protein tyrosine kinase activity
X802_03545	COG0864	Transcriptional regulator
X802_03555	COG0489	protein tyrosine kinase activity
X802_03580	COG0746	molybdenum cofactor guanylyltransferase activity
X802_03585	COG0651	ATP synthesis coupled electron transport
X802_03590	COG1863	multisubunit Na H antiporter MnhE subunit
X802_03595	COG1006	Multisubunit Na H antiporter MnhC subunit
X802_03610	COG1320	monovalent cation:proton antiporter activity
X802_03625	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
X802_03640	COG3260	NADH ubiquinone oxidoreductase 20
X802_03645	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
X802_03650	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
X802_03650	COG3261	NADH dehydrogenase
X802_03655	COG0650	Formate hydrogenlyase subunit 4
X802_03660	COG0651	ATP synthesis coupled electron transport
X802_03665	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
X802_03665	COG2111	Na H antiporter
X802_03670	COG0437	4 iron, 4 sulfur cluster binding
X802_03675	COG0243	molybdopterin cofactor binding
X802_03680	COG1309	transcriptional regulator
X802_03690	COG0298	carbon dioxide binding
X802_03695	COG0409	Hydrogenase expression formation protein
X802_03705	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
X802_03715	COG1373	ATPase (AAA superfamily
X802_03735	COG0309	Hydrogenase expression formation protein (HypE)
X802_03745	COG1013	pyruvate-flavodoxin oxidoreductase activity
X802_03750	COG0674	pyruvate-flavodoxin oxidoreductase activity
X802_03755	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
X802_03755	COG1144	Oxidoreductase
X802_03760	COG1013	pyruvate-flavodoxin oxidoreductase activity
X802_03765	COG0674	pyruvate-flavodoxin oxidoreductase activity
X802_03780	COG0306	phosphate transporter
X802_03785	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
X802_03795	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
X802_03810	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
X802_03830	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
X802_03840	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
X802_03845	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
X802_03850	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
X802_03870	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
X802_03895	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
X802_03910	COG0312	modulator of DNA gyrase
X802_03925	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
X802_04000	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
X802_04030	COG0037	tRNA processing
X802_04040	COG1449	Belongs to the glycosyl hydrolase 57 family
X802_04060	COG0475	glutathione-regulated potassium exporter activity
X802_04095	COG0297	glycogen (starch) synthase activity
X802_04095	COG0438	transferase activity, transferring glycosyl groups
X802_04105	COG1442	glycosyl transferase family 8
X802_04105	COG1216	Glycosyl transferase, family 2
X802_04130	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
X802_04135	COG0438	transferase activity, transferring glycosyl groups
X802_04140	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
X802_04155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
X802_04160	COG0037	tRNA processing
X802_04240	COG0650	Formate hydrogenlyase subunit 4
X802_04250	COG3261	NADH dehydrogenase
X802_04250	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
X802_04255	COG3260	NADH ubiquinone oxidoreductase 20
X802_04290	COG1320	monovalent cation:proton antiporter activity
X802_04295	COG2212	antiporter activity
X802_04300	COG1863	multisubunit Na H antiporter MnhE subunit
X802_04310	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
X802_04315	COG3259	Nickel-dependent hydrogenase
X802_04330	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
X802_04345	COG0148	phosphopyruvate hydratase activity
X802_04390	COG0235	Class ii aldolase
X802_04400	COG2610	gluconate transmembrane transporter activity
X802_04405	COG2379	hydroxypyruvate reductase
X802_04410	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
X802_04435	COG0095	Lipoate-protein ligase
X802_04460	COG1980	fructose-bisphosphate aldolase activity
X802_04485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
X802_04495	COG0306	phosphate transporter
X802_04500	COG1392	Phosphate transport regulator
X802_04520	COG4946	Tricorn protease homolog
X802_04520	COG0823	Involved in the tonB-independent uptake of proteins
X802_04520	COG1506	peptidase
X802_04550	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
X802_04570	COG0681	Belongs to the peptidase S26 family
X802_04580	COG1401	restriction endodeoxyribonuclease activity
X802_04615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
X802_04625	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
X802_04640	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
X802_04645	COG0402	S-adenosylhomocysteine deaminase activity
X802_04655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
X802_04665	COG1269	ATP hydrolysis coupled proton transport
X802_04675	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
X802_04685	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
X802_04690	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
X802_04710	COG0482	sulfurtransferase activity
X802_04785	COG1522	sequence-specific DNA binding
X802_04790	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
X802_04810	COG0314	molybdopterin synthase activity
X802_04820	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
X802_04830	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
X802_04845	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
X802_04850	COG0492	ferredoxin-NADP+ reductase activity
X802_04860	COG2255	four-way junction helicase activity
X802_04865	COG0116	Belongs to the methyltransferase superfamily
X802_04880	COG2442	InterPro IPR007367
X802_04885	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
X802_04905	COG0714	Associated with various cellular activities
X802_04940	COG1047	Peptidyl-prolyl cis-trans
X802_04975	COG1160	GTP binding
X802_04980	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
X802_04980	COG0116	Belongs to the methyltransferase superfamily
X802_05000	COG0179	Fumarylacetoacetate (FAA) hydrolase
X802_05045	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
X802_05065	COG2095	MarC family integral membrane protein
X802_05070	COG0475	glutathione-regulated potassium exporter activity
X802_05075	COG0475	glutathione-regulated potassium exporter activity
X802_05080	COG0517	IMP dehydrogenase activity
X802_05090	COG0434	BtpA family
X802_05100	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
X802_05140	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
X802_05145	COG0540	Belongs to the ATCase OTCase family
X802_05150	COG1992	Thiamine-phosphate synthase
X802_05150	COG0351	phosphomethylpyrimidine kinase
X802_05160	COG0432	Pfam Uncharacterised protein family UPF0047
X802_05230	COG3885	ferrous iron binding
X802_05230	COG2078	PFAM AMMECR1 domain protein
X802_05250	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
X802_05255	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
X802_05275	COG3557	Belongs to the UPF0374 family
X802_05285	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
X802_05305	COG2255	four-way junction helicase activity
X802_05310	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
X802_05320	COG0156	8-amino-7-oxononanoate synthase activity
X802_05335	COG0456	acetyltransferase
X802_05345	COG1120	ATPase activity
X802_05365	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
X802_05410	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
X802_05415	COG1373	ATPase (AAA superfamily
X802_05420	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
X802_05440	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
X802_05470	COG0543	2 iron, 2 sulfur cluster binding
X802_05475	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
X802_05485	COG0601	transmembrane transport
X802_05490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
X802_05495	COG0444	Belongs to the ABC transporter superfamily
X802_05500	COG4608	Belongs to the ABC transporter superfamily
X802_05515	COG0174	glutamine synthetase
X802_05555	COG1254	Belongs to the acylphosphatase family
X802_05565	COG1628	Protein of unknown function DUF99
X802_05570	COG0589	response to stress
X802_05575	COG0404	The glycine cleavage system catalyzes the degradation of glycine
X802_05615	COG1122	ATPase activity
X802_05625	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
X802_05640	COG0167	dihydroorotate dehydrogenase activity
X802_05670	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
X802_05705	COG2151	metal-sulfur cluster biosynthetic enzyme
X802_05710	COG1141	Ferredoxin
X802_05730	COG2971	BadF BadG BcrA BcrD
X802_05740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
X802_05745	COG0601	transmembrane transport
X802_05755	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
X802_05770	COG0673	inositol 2-dehydrogenase activity
X802_05785	COG4821	SIS domain
X802_05810	COG0651	ATP synthesis coupled electron transport
X802_05820	COG1006	Multisubunit Na H antiporter MnhC subunit
X802_05835	COG1320	monovalent cation:proton antiporter activity
X802_05840	COG2212	antiporter activity
X802_05845	COG3260	NADH ubiquinone oxidoreductase 20
X802_05850	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
X802_05855	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
X802_05855	COG3261	NADH dehydrogenase
X802_05860	COG0650	Formate hydrogenlyase subunit 4
X802_05865	COG0651	ATP synthesis coupled electron transport
X802_05885	COG1151	hydroxylamine reductase activity
X802_05890	COG0437	4 iron, 4 sulfur cluster binding
X802_05920	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
X802_05945	COG1287	oligosaccharyl transferase activity
X802_05960	COG0438	transferase activity, transferring glycosyl groups
X802_06000	COG2414	aldehyde ferredoxin oxidoreductase
X802_06030	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
X802_06045	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
X802_06060	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
X802_06090	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
X802_06105	COG0010	Belongs to the arginase family
X802_06115	COG0038	chloride channel
X802_06130	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
X802_06150	COG0438	transferase activity, transferring glycosyl groups
X802_06280	COG1836	PFAM Integral membrane protein DUF92
X802_06285	COG1522	sequence-specific DNA binding
X802_06315	COG2252	PERMEase
X802_06360	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
X802_06375	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
X802_06390	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
X802_06395	COG0081	regulation of translation
X802_06410	COG0717	Belongs to the dCTP deaminase family
X802_06465	COG0557	exoribonuclease II activity
X802_06490	COG2890	protein-(glutamine-N5) methyltransferase activity
X802_06550	COG0519	Catalyzes the synthesis of GMP from XMP
X802_06550	COG0518	GMP synthase (glutamine-hydrolyzing) activity
X802_06565	COG0518	GMP synthase (glutamine-hydrolyzing) activity
X802_06565	COG0519	Catalyzes the synthesis of GMP from XMP
X802_06570	COG0517	IMP dehydrogenase activity
X802_06570	COG0516	GMP reductase activity
X802_06585	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
X802_06590	COG0047	phosphoribosylformylglycinamidine synthase activity
X802_06615	COG0151	Belongs to the GarS family
X802_06630	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
X802_06660	COG1122	ATPase activity
X802_06675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
X802_06675	COG1042	CoA-binding domain protein
X802_06675	COG0045	succinate-CoA ligase (ADP-forming) activity
X802_06740	COG0656	L-ascorbic acid biosynthetic process
X802_06750	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
X802_06760	COG0516	GMP reductase activity
X802_06760	COG0517	IMP dehydrogenase activity
X802_06765	COG0402	S-adenosylhomocysteine deaminase activity
X802_06770	COG0017	Asparaginyl-tRNA synthetase
X802_06785	COG2403	cyclic 2,3-diphosphoglycerate synthetase activity
X802_06795	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
X802_06800	COG0517	IMP dehydrogenase activity
X802_06800	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
X802_06815	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
X802_06840	COG0649	NAD binding
X802_06845	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
X802_06845	COG0649	NAD binding
X802_06845	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
X802_06850	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
X802_06865	COG0651	ATP synthesis coupled electron transport
X802_06870	COG1006	Multisubunit Na H antiporter MnhC subunit
X802_06875	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
X802_06875	COG2111	Na H antiporter
X802_06885	COG1320	monovalent cation:proton antiporter activity
X802_06890	COG2212	antiporter activity
X802_06895	COG1863	multisubunit Na H antiporter MnhE subunit
X802_06905	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
X802_06925	COG0018	arginyl-trna synthetase
X802_06945	COG0012	GTP binding
X802_06955	COG0525	valine-tRNA ligase activity
X802_06975	COG2264	protein methyltransferase activity
X802_07030	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
X802_07035	COG1968	undecaprenyl-diphosphatase activity
X802_07060	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
X802_07065	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
X802_07075	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
X802_07080	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
X802_07090	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
X802_07095	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
X802_07105	COG0157	Belongs to the NadC ModD family
X802_07110	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
X802_07115	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
X802_07135	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
X802_07160	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
X802_07170	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
X802_07180	COG1297	OPT oligopeptide transporter protein
X802_07185	COG1234	tRNA 3'-trailer cleavage
X802_07200	COG3842	ATPase activity
X802_07215	COG1175	transmembrane transport
X802_07230	COG1378	Sugar-specific transcriptional regulator TrmB
X802_07235	COG1653	transport
X802_07240	COG1175	transmembrane transport
X802_07245	COG0395	ABC-type sugar transport system, permease component
X802_07250	COG0438	transferase activity, transferring glycosyl groups
X802_07260	COG0297	glycogen (starch) synthase activity
X802_07335	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
X802_07350	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
X802_07380	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
X802_07385	COG1201	RNA secondary structure unwinding
X802_07410	COG1342	Belongs to the UPF0251 family
X802_07415	COG0455	bacterial-type flagellum organization
X802_07420	COG0489	protein tyrosine kinase activity
X802_07425	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
X802_07425	COG0731	radical SAM domain protein
X802_07440	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
X802_07460	COG0730	response to heat
X802_07465	COG0730	response to heat
X802_07470	COG0339	signal peptide processing
X802_07485	COG0396	ATPase activity
X802_07490	COG0719	Fe-S assembly protein
X802_07595	COG2226	methyltransferase
X802_07600	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
X802_07605	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
X802_07630	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
X802_07640	COG0746	molybdenum cofactor guanylyltransferase activity
X802_07665	COG1851	Uncharacterised protein family (UPF0128)
X802_07675	COG1435	thymidine kinase activity
X802_07685	COG0330	HflC and HflK could
X802_07690	COG2815	serine threonine protein kinase
X802_07690	COG0515	serine threonine protein kinase
X802_07740	COG1695	Transcriptional regulator
X802_07780	COG2264	protein methyltransferase activity
X802_07795	COG1492	cobalamin metabolic process
X802_07815	COG0432	Pfam Uncharacterised protein family UPF0047
X802_07850	COG1489	DNA binding
X802_07885	COG1185	polyribonucleotide nucleotidyltransferase activity
X802_07915	COG1216	Glycosyl transferase, family 2
X802_07960	COG1056	cytidyltransferase-related domain
X802_07960	COG1051	belongs to the nudix hydrolase family
X802_07965	COG1132	(ABC) transporter
X802_07970	COG1132	(ABC) transporter
X802_07980	COG0535	radical SAM domain protein
X802_08035	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
X802_08040	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
X802_08065	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
X802_08075	COG1063	alcohol dehydrogenase
X802_08080	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
X802_08085	COG2894	cell division
X802_08105	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
X802_08110	COG0252	asparaginase activity
X802_08120	COG1515	deoxyribonuclease V activity
X802_08165	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
X802_08170	COG0509	glycine decarboxylation via glycine cleavage system
X802_08180	COG0438	transferase activity, transferring glycosyl groups
X802_08200	COG0493	'glutamate synthase
X802_08200	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
X802_08205	COG0543	2 iron, 2 sulfur cluster binding
X802_08235	COG0747	negative chemotaxis
X802_08240	COG0601	transmembrane transport
X802_08250	COG0444	Belongs to the ABC transporter superfamily
X802_08255	COG4608	Belongs to the ABC transporter superfamily
X802_08280	COG0428	transporter
X802_08290	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
X802_08335	COG0024	Methionine aminopeptidase
X802_08580	COG0167	dihydroorotate dehydrogenase activity
X802_08580	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
X802_08585	COG1137	ATPase activity
X802_08625	COG1129	ABC transporter
X802_08630	COG1205	dead DEAH box helicase
X802_08630	COG1111	helicase
X802_08650	COG1739	Uncharacterized protein family UPF0029
X802_08675	COG1335	isochorismatase
X802_08705	COG1013	pyruvate-flavodoxin oxidoreductase activity
X802_08740	COG1476	TRANSCRIPTIONal
X802_08750	COG1131	(ABC) transporter
X802_08815	COG1522	sequence-specific DNA binding
X802_08820	COG0163	prenyltransferase activity
X802_08845	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
X802_08845	COG1918	ferrous iron import across plasma membrane
X802_08855	COG0482	sulfurtransferase activity
X802_08875	COG0006	proline dipeptidase activity
X802_08895	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
X802_08905	COG1121	(ABC) transporter
X802_08915	COG1234	tRNA 3'-trailer cleavage
X802_08930	COG1994	Peptidase M50
X802_08935	COG2140	Oxalate decarboxylase
X802_08940	COG0436	Aminotransferase
X802_08950	COG0501	Belongs to the peptidase M48B family
X802_08955	COG2131	deaminase
X802_08965	COG0546	phosphoglycolate phosphatase activity
X802_08980	COG0693	protein deglycase activity
X802_09010	COG2095	MarC family integral membrane protein
X802_09015	COG1765	OsmC-like protein
X802_09025	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
X802_09030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
X802_09040	COG0051	transcription antitermination factor activity, RNA binding
X802_09050	COG2192	nodulation
X802_09055	COG0442	prolyl-tRNA aminoacylation
X802_09060	COG0446	pyridine nucleotide-disulphide oxidoreductase
X802_09090	COG1404	Belongs to the peptidase S8 family
X802_09095	COG0574	Belongs to the PEP-utilizing enzyme family
X802_09095	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
X802_09100	COG0534	Mate efflux family protein
X802_09105	COG0534	Mate efflux family protein
X802_09110	COG1505	serine-type exopeptidase activity
X802_09130	COG0534	Mate efflux family protein
X802_09135	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
X802_09145	COG0315	cyclic pyranopterin monophosphate synthase activity
X802_09185	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
X802_09195	COG0277	FAD linked oxidase domain protein
X802_09200	COG1899	peptidyl-lysine modification to peptidyl-hypusine
X802_09210	COG4555	ABC transporter
X802_09225	COG1028	Short-chain dehydrogenase reductase Sdr
X802_09235	COG0459	protein refolding
X802_09260	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
X802_09265	COG0668	transmembrane transport
X802_09320	COG0560	Phosphoserine phosphatase
X802_09335	COG2234	aminopeptidase activity
X802_09345	COG1522	sequence-specific DNA binding
X802_09350	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
X802_09410	COG1476	TRANSCRIPTIONal
X802_09415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
X802_09420	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
X802_09425	COG2267	carboxylic ester hydrolase activity
X802_09440	COG0602	queuosine metabolic process
X802_09455	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
X802_09465	COG0126	phosphoglycerate kinase activity
X802_09470	COG1078	dGTPase activity
X802_09490	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
X802_09500	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
X802_09545	COG1196	nuclear chromosome segregation
X802_09560	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
X802_09575	COG1473	amidohydrolase
X802_09580	COG0456	acetyltransferase
X802_09580	COG1214	PFAM Peptidase M22, glycoprotease
X802_09585	COG0561	phosphatase activity
X802_09590	COG1984	allophanate hydrolase subunit 2
X802_09595	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
X802_09600	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
X802_09610	COG1914	H( )-stimulated, divalent metal cation uptake system
X802_09640	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
X802_09685	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
X802_09685	COG0045	succinate-CoA ligase (ADP-forming) activity
X802_09685	COG1042	CoA-binding domain protein
X802_09705	COG1122	ATPase activity
X802_09730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
X802_09745	COG0084	hydrolase, TatD family'
X802_09780	COG1151	hydroxylamine reductase activity
X802_09825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
X802_09830	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
X802_09850	COG2033	superoxide reductase activity
X802_09860	COG1592	Rubrerythrin
X802_09915	COG0798	PFAM Bile acid sodium symporter
X802_09940	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
X802_09990	COG0450	alkyl hydroperoxide reductase
X802_09995	COG0243	molybdopterin cofactor binding
X802_10000	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
X802_10000	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
X802_10005	COG0307	riboflavin synthase, alpha
X802_10010	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
X802_10010	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
X802_10015	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
X802_10025	COG0668	transmembrane transport
X802_10040	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
X802_10045	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
X802_10050	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
X802_10055	COG0351	phosphomethylpyrimidine kinase
X802_10055	COG1992	Thiamine-phosphate synthase
X802_10060	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
X802_10085	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
X802_10175	COG1203	CRISPR-associated helicase, Cas3
X802_10180	COG1466	dna polymerase III delta subunit
X802_10190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
X802_10195	COG1518	maintenance of DNA repeat elements
X802_10240	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
X802_10275	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
X802_10295	COG4149	molybdate abc transporter
X802_10300	COG3842	ATPase activity
X802_10315	COG2264	protein methyltransferase activity
X802_10320	COG0312	modulator of DNA gyrase
X802_10325	COG0312	modulator of DNA gyrase
X802_10345	COG0598	Magnesium transport protein CorA
X802_10350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
X802_10355	COG0823	Involved in the tonB-independent uptake of proteins
X802_10355	COG1506	peptidase
X802_10355	COG4946	Tricorn protease homolog
X802_10385	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
X802_10400	COG2226	methyltransferase
X802_10435	COG0436	Aminotransferase
X802_10440	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
X802_10440	COG2050	protein possibly involved in aromatic compounds catabolism
X802_10445	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
X802_10460	COG1444	tRNA N-acetyltransferase activity
X802_10470	COG1794	racemase activity, acting on amino acids and derivatives
X802_10530	COG1794	racemase activity, acting on amino acids and derivatives
X802_10535	COG2096	Adenosyltransferase
X802_10545	COG2814	Major facilitator Superfamily
X802_10600	COG1363	Peptidase, m42
X802_10605	COG0720	synthase
X802_10610	COG1131	(ABC) transporter
X802_10635	COG1013	pyruvate-flavodoxin oxidoreductase activity
X802_10640	COG0674	pyruvate-flavodoxin oxidoreductase activity
X802_10640	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
X802_10660	COG1013	pyruvate-flavodoxin oxidoreductase activity
X802_10665	COG0674	pyruvate-flavodoxin oxidoreductase activity
X802_10665	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
X802_10680	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
X802_10695	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
X802_10725	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
X802_10730	COG1078	dGTPase activity
X802_10770	COG0371	Dehydrogenase
X802_10780	COG0483	inositol monophosphate 1-phosphatase activity
X802_10790	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
X802_10805	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
X802_10820	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
X802_10830	COG1446	asparaginase
X802_10835	COG0697	spore germination
X802_10840	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
X802_10840	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
X802_10880	COG2205	protein histidine kinase activity