locus-tag	class	description
TK0002	COG1451	nucleotide metabolic process
TK0005	COG1832	CoA-binding protein
TK0012	COG1160	GTP binding
TK0015	COG0725	ABC transporter, periplasmic molybdate-binding protein
TK0018	COG4149	molybdate abc transporter
TK0019	COG1106	Psort location Cytoplasmic, score
TK0021	COG3842	ATPase activity
TK0026	COG0546	phosphoglycolate phosphatase activity
TK0028	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TK0030	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
TK0037	COG2226	methyltransferase
TK0051	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TK0052	COG0560	Phosphoserine phosphatase
TK0067	COG1051	belongs to the nudix hydrolase family
TK0067	COG1056	cytidyltransferase-related domain
TK0072	COG2414	aldehyde ferredoxin oxidoreductase
TK0076	COG1404	Belongs to the peptidase S8 family
TK0107	COG1321	iron dependent repressor
TK0115	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TK0123	COG2814	Major facilitator Superfamily
TK0125	COG0456	acetyltransferase
TK0134	COG0123	including yeast histone deacetylase and acetoin utilization protein
TK0141	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TK0147	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TK0150	COG0509	glycine decarboxylation via glycine cleavage system
TK0155	COG1185	polyribonucleotide nucleotidyltransferase activity
TK0157	COG2252	PERMEase
TK0158	COG3842	ATPase activity
TK0159	COG4149	molybdate abc transporter
TK0173	COG0011	TIGRFAM Protein of
TK0174	COG2078	PFAM AMMECR1 domain protein
TK0180	COG0183	Belongs to the thiolase family
TK0181	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TK0185	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TK0186	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TK0187	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TK0189	COG1765	OsmC-like protein
TK0190	COG0519	Catalyzes the synthesis of GMP from XMP
TK0190	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TK0193	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TK0193	COG0519	Catalyzes the synthesis of GMP from XMP
TK0194	COG0517	IMP dehydrogenase activity
TK0194	COG0516	GMP reductase activity
TK0197	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TK0198	COG2814	Major facilitator Superfamily
TK0200	COG0574	Belongs to the PEP-utilizing enzyme family
TK0200	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TK0201	COG0047	phosphoribosylformylglycinamidine synthase activity
TK0204	COG0151	Belongs to the GarS family
TK0207	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
TK0208	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TK0210	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TK0211	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TK0214	COG3383	formate dehydrogenase (NAD+) activity
TK0216	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TK0217	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TK0218	COG0157	Belongs to the NadC ModD family
TK0219	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TK0224	COG2226	methyltransferase
TK0234	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TK0243	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TK0245	COG0131	Imidazoleglycerol-phosphate dehydratase
TK0246	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TK0247	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TK0248	COG0107	imidazoleglycerol-phosphate synthase activity
TK0249	COG0140	phosphoribosyl-ATP diphosphatase activity
TK0249	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TK0250	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TK0254	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TK0255	COG0512	Glutamine amidotransferase of anthranilate synthase
TK0255	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TK0257	COG0133	tryptophan synthase activity
TK0258	COG0159	tryptophan synthase activity
TK0260	COG0436	Aminotransferase
TK0265	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TK0266	COG0710	3-dehydroquinate dehydratase activity
TK0267	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TK0268	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TK0269	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TK0272	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TK0273	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TK0274	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TK0275	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TK0277	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TK0278	COG0189	ligase activity
TK0280	COG0473	3-isopropylmalate dehydrogenase activity
TK0281	COG0066	3-isopropylmalate dehydratase activity
TK0282	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TK0284	COG0778	Nitroreductase
TK0288	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TK0296	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TK0297	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TK0306	COG0513	Belongs to the DEAD box helicase family
TK0307	COG0051	transcription antitermination factor activity, RNA binding
TK0308	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TK0309	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TK0312	COG1078	dGTPase activity
TK0313	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TK0314	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TK0317	COG0084	hydrolase, TatD family'
TK0327	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TK0328	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TK0328	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TK0330	COG0346	lactoylglutathione lyase activity
TK0332	COG1984	allophanate hydrolase subunit 2
TK0333	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TK0336	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TK0338	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TK0345	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TK0348	COG0330	HflC and HflK could
TK0349	COG2894	cell division
TK0352	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
TK0354	COG0315	cyclic pyranopterin monophosphate synthase activity
TK0355	COG1131	(ABC) transporter
TK0357	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
TK0360	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TK0360	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TK0364	COG1216	Glycosyl transferase, family 2
TK0366	COG0301	tRNA thio-modification
TK0368	COG0301	tRNA thio-modification
TK0423	COG1505	serine-type exopeptidase activity
TK0424	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TK0424	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TK0425	COG0307	riboflavin synthase, alpha
TK0428	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TK0428	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TK0429	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TK0432	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TK0434	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
TK0435	COG0352	thiamine-phosphate diphosphorylase activity
TK0435	COG0351	phosphomethylpyrimidine kinase
TK0436	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
TK0444	COG0215	cysteine-tRNA ligase activity
TK0445	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TK0455	COG1518	maintenance of DNA repeat elements
TK0459	COG1466	dna polymerase III delta subunit
TK0460	COG1203	CRISPR-associated helicase, Cas3
TK0470	COG1110	DNA topoisomerase II activity
TK0474	COG0010	Belongs to the arginase family
TK0475	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
TK0480	COG1418	mRNA catabolic process
TK0492	COG0017	Asparaginyl-tRNA synthetase
TK0497	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TK0499	COG0312	modulator of DNA gyrase
TK0502	COG0312	modulator of DNA gyrase
TK0504	COG1794	racemase activity, acting on amino acids and derivatives
TK0505	COG0598	Magnesium transport protein CorA
TK0506	COG0012	GTP binding
TK0508	COG1522	sequence-specific DNA binding
TK0509	COG0163	prenyltransferase activity
TK0511	COG0469	pyruvate kinase activity
TK0514	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TK0515	COG1993	acr, cog1993
TK0519	COG1739	Uncharacterized protein family UPF0029
TK0521	COG1111	helicase
TK0521	COG1205	dead DEAH box helicase
TK0523	COG1592	Rubrerythrin
TK0524	COG1773	rubredoxin
TK0525	COG2033	superoxide reductase activity
TK0537	COG0450	alkyl hydroperoxide reductase
TK0540	COG1078	dGTPase activity
TK0541	COG0303	'Molybdopterin
TK0545	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
TK0547	COG0420	3'-5' exonuclease activity
TK0548	COG0436	Aminotransferase
TK0549	COG2192	nodulation
TK0550	COG0442	prolyl-tRNA aminoacylation
TK0551	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TK0556	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TK0558	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
TK0561	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TK0562	COG1342	Belongs to the UPF0251 family
TK0567	COG1522	sequence-specific DNA binding
TK0571	COG4208	sulfate ABC transporter
TK0572	COG3842	ATPase activity
TK0601	COG3842	ATPase activity
TK0618	COG1863	multisubunit Na H antiporter MnhE subunit
TK0619	COG2212	antiporter activity
TK0625	COG0651	ATP synthesis coupled electron transport
TK0626	COG0440	acetolactate synthase activity
TK0630	COG0840	transmembrane signaling receptor activity
TK0631	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TK0632	COG2201	protein-glutamate methylesterase activity
TK0633	COG2201	protein-glutamate methylesterase activity
TK0634	COG0643	Histidine kinase
TK0634	COG2198	Histidine kinase
TK0635	COG0643	Histidine kinase
TK0635	COG2198	Histidine kinase
TK0638	COG0840	transmembrane signaling receptor activity
TK0639	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
TK0645	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TK0649	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TK0649	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TK0665	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TK0665	COG0045	succinate-CoA ligase (ADP-forming) activity
TK0665	COG1042	CoA-binding domain protein
TK0669	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TK0671	COG1899	peptidyl-lysine modification to peptidyl-hypusine
TK0672	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TK0672	COG0493	'glutamate synthase
TK0673	COG1028	Short-chain dehydrogenase reductase Sdr
TK0675	COG0641	radical SAM
TK0676	COG1132	(ABC) transporter
TK0677	COG0501	Belongs to the peptidase M48B family
TK0678	COG0459	protein refolding
TK0679	COG0515	serine threonine protein kinase
TK0682	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TK0683	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TK0685	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TK0690	COG0243	molybdopterin cofactor binding
TK0698	COG0312	modulator of DNA gyrase
TK0701	COG0489	protein tyrosine kinase activity
TK0702	COG0489	protein tyrosine kinase activity
TK0703	COG0731	radical SAM domain protein
TK0703	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TK0704	COG2226	methyltransferase
TK0705	COG1012	belongs to the aldehyde dehydrogenase family
TK0708	COG1120	ATPase activity
TK0714	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TK0714	COG1918	ferrous iron import across plasma membrane
TK0717	COG0725	ABC transporter, periplasmic molybdate-binding protein
TK0719	COG3842	ATPase activity
TK0727	COG1131	(ABC) transporter
TK0730	COG0719	Fe-S assembly protein
TK0731	COG0396	ATPase activity
TK0735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TK0745	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TK0746	COG1122	ATPase activity
TK0747	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
TK0747	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
TK0748	COG1268	BioY protein
TK0752	COG4946	Tricorn protease homolog
TK0752	COG0823	Involved in the tonB-independent uptake of proteins
TK0752	COG1506	peptidase
TK0754	COG1444	tRNA N-acetyltransferase activity
TK0757	COG4143	(ABC) transporter
TK0758	COG0402	S-adenosylhomocysteine deaminase activity
TK0759	COG0017	Asparaginyl-tRNA synthetase
TK0764	COG1201	RNA secondary structure unwinding
TK0764	COG1201	RNA secondary structure unwinding
TK0768	COG1872	DUF167
TK0772	COG2409	Drug exporters of the RND superfamily
TK0775	COG1363	Peptidase, m42
TK0777	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TK0779	COG1489	DNA binding
TK0784	COG1199	ATP-dependent helicase activity
TK0786	COG0457	Tetratricopeptide repeat
TK0786	COG0705	Rhomboid family
TK0787	COG0483	inositol monophosphate 1-phosphatase activity
TK0789	COG1979	alcohol dehydrogenase
TK0793	COG1469	GTP cyclohydrolase I activity
TK0795	COG1401	restriction endodeoxyribonuclease activity
TK0799	COG2205	protein histidine kinase activity
TK0803	COG1121	(ABC) transporter
TK0805	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TK0809	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TK0812	COG0563	adenylate kinase activity
TK0814	COG0426	domain, Protein
TK0814	COG1773	rubredoxin
TK0816	COG1013	pyruvate-flavodoxin oxidoreductase activity
TK0819	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TK0819	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TK0828	COG0446	pyridine nucleotide-disulphide oxidoreductase
TK0835	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TK0836	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TK0837	COG2217	Heavy metal translocating P-type atpase
TK0842	COG0798	PFAM Bile acid sodium symporter
TK0843	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TK0845	COG0667	Aldo Keto reductase
TK0854	COG1492	cobalamin metabolic process
TK0856	COG0746	molybdenum cofactor guanylyltransferase activity
TK0857	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TK0863	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TK0864	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TK0865	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TK0866	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TK0870	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TK0871	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TK0880	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TK0882	COG0010	Belongs to the arginase family
TK0884	COG0475	glutathione-regulated potassium exporter activity
TK0886	COG0038	chloride channel
TK0890	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TK0899	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TK0906	COG1515	deoxyribonuclease V activity
TK0908	COG0252	asparaginase activity
TK0911	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TK0915	COG2894	cell division
TK0916	COG1063	alcohol dehydrogenase
TK0921	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TK0927	COG0101	tRNA pseudouridine synthase activity
TK0928	COG0556	nucleotide-excision repair
TK0942	COG1131	(ABC) transporter
TK0943	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TK0943	COG0045	succinate-CoA ligase (ADP-forming) activity
TK0943	COG1042	CoA-binding domain protein
TK0948	COG0009	L-threonylcarbamoyladenylate synthase
TK0950	COG0367	asparagine synthase
TK0952	COG2894	cell division
TK0953	COG4956	integral membrane protein (PIN domain superfamily)
TK0954	COG0424	maF-like protein
TK0955	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TK0957	COG1918	ferrous iron import across plasma membrane
TK0957	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TK0967	COG0006	proline dipeptidase activity
TK0970	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
TK0974	COG0534	Mate efflux family protein
TK0978	COG0423	glycine-tRNA ligase activity
TK0979	COG0730	response to heat
TK0981	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TK0984	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TK0986	COG1301	dicarboxylic acid transport
TK0987	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
TK0987	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
TK0989	COG1830	Aldolase
TK0991	COG1966	Carbon starvation protein
TK0994	COG0003	Pfam Anion-transporting ATPase
TK0995	COG2151	metal-sulfur cluster biosynthetic enzyme
TK0999	COG2267	carboxylic ester hydrolase activity
TK1002	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TK1004	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TK1009	COG1401	restriction endodeoxyribonuclease activity
TK1011	COG0477	Major facilitator Superfamily
TK1012	COG2814	Major facilitator Superfamily
TK1015	COG1201	RNA secondary structure unwinding
TK1017	COG1196	nuclear chromosome segregation
TK1021	COG0513	Belongs to the DEAD box helicase family
TK1026	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
TK1031	COG1129	ABC transporter
TK1036	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TK1036	COG0517	IMP dehydrogenase activity
TK1037	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TK1039	COG2403	cyclic 2,3-diphosphoglycerate synthetase activity
TK1044	COG2814	Major facilitator Superfamily
TK1045	COG2096	Adenosyltransferase
TK1047	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TK1048	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TK1053	COG0730	response to heat
TK1055	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TK1063	COG0668	transmembrane transport
TK1066	COG2414	aldehyde ferredoxin oxidoreductase
TK1071	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TK1076	COG2002	toxin-antitoxin pair type II binding
TK1077	COG0049	tRNA binding
TK1081	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TK1082	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TK1083	COG0085	RNA polymerase activity
TK1091	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TK1094	COG0436	Aminotransferase
TK1100	COG1185	polyribonucleotide nucleotidyltransferase activity
TK1103	COG0310	cobalt ion transport
TK1106	COG1122	ATPase activity
TK1111	COG2140	Oxalate decarboxylase
TK1114	COG1234	tRNA 3'-trailer cleavage
TK1116	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TK1119	COG0720	synthase
TK1124	COG1013	pyruvate-flavodoxin oxidoreductase activity
TK1125	COG0674	pyruvate-flavodoxin oxidoreductase activity
TK1125	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TK1129	COG1013	pyruvate-flavodoxin oxidoreductase activity
TK1130	COG0674	pyruvate-flavodoxin oxidoreductase activity
TK1130	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TK1137	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TK1139	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TK1140	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TK1141	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TK1146	COG0126	phosphoglycerate kinase activity
TK1155	COG0071	Belongs to the small heat shock protein (HSP20) family
TK1157	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TK1161	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TK1162	COG0628	permease
TK1170	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TK1173	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TK1181	COG1122	ATPase activity
TK1182	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TK1183	COG0024	Methionine aminopeptidase
TK1186	COG0516	GMP reductase activity
TK1186	COG0517	IMP dehydrogenase activity
TK1190	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TK1193	COG0504	CTP synthase activity
TK1198	COG0602	queuosine metabolic process
TK1199	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TK1205	COG1881	PFAM PEBP family protein
TK1215	COG0649	NAD binding
TK1216	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TK1217	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TK1220	COG0651	ATP synthesis coupled electron transport
TK1222	COG2111	Na H antiporter
TK1222	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TK1224	COG1320	monovalent cation:proton antiporter activity
TK1226	COG1863	multisubunit Na H antiporter MnhE subunit
TK1231	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TK1235	COG0018	arginyl-trna synthetase
TK1237	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TK1251	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TK1252	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TK1257	COG0301	tRNA thio-modification
TK1257	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TK1258	COG1836	PFAM Integral membrane protein DUF92
TK1259	COG1522	sequence-specific DNA binding
TK1260	COG1694	Mazg nucleotide pyrophosphohydrolase
TK1261	COG0640	Transcriptional regulator
TK1264	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TK1266	COG1476	TRANSCRIPTIONal
TK1273	COG2226	methyltransferase
TK1274	COG0525	valine-tRNA ligase activity
TK1282	COG0303	'Molybdopterin
TK1284	COG0693	protein deglycase activity
TK1285	COG1522	sequence-specific DNA binding
TK1286	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TK1287	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TK1288	COG0534	Mate efflux family protein
TK1289	COG0534	Mate efflux family protein
TK1292	COG0574	Belongs to the PEP-utilizing enzyme family
TK1292	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TK1299	COG0446	pyridine nucleotide-disulphide oxidoreductase
TK1305	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TK1307	COG0105	UTP biosynthetic process
TK1315	COG0175	sulfate reduction
TK1316	COG0330	HflC and HflK could
TK1323	COG0438	transferase activity, transferring glycosyl groups
TK1324	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TK1325	COG0493	'glutamate synthase
TK1326	COG0543	2 iron, 2 sulfur cluster binding
TK1337	COG1131	(ABC) transporter
TK1339	COG1476	TRANSCRIPTIONal
TK1379	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TK1380	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TK1387	COG2339	peptidase activity
TK1393	COG0579	oxidoreductase
TK1395	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TK1397	COG0584	glycerophosphoryl diester phosphodiesterase
TK1398	COG0584	glycerophosphoryl diester phosphodiesterase
TK1399	COG2211	Major facilitator Superfamily
TK1400	COG2271	Major facilitator Superfamily
TK1401	COG1073	alpha beta
TK1403	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TK1406	COG0058	SHG alpha-glucan phosphorylase activity
TK1408	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TK1414	COG0717	Belongs to the dCTP deaminase family
TK1417	COG0081	regulation of translation
TK1418	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TK1421	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TK1426	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TK1428	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TK1429	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TK1431	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TK1432	COG0733	neurotransmitter:sodium symporter activity
TK1435	COG0347	Belongs to the P(II) protein family
TK1436	COG1543	Belongs to the glycosyl hydrolase 57 family
TK1439	COG0864	Transcriptional regulator
TK1442	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
TK1443	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TK1444	COG0083	homoserine kinase activity
TK1445	COG0527	aspartate kinase activity
TK1446	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
TK1452	COG1132	(ABC) transporter
TK1461	COG0495	leucyl-tRNA aminoacylation
TK1466	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TK1468	COG0142	geranyltranstransferase activity
TK1470	COG1304	FMN binding
TK1471	COG1794	racemase activity, acting on amino acids and derivatives
TK1472	COG1058	Belongs to the CinA family
TK1472	COG1546	Belongs to the CinA family
TK1474	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TK1477	COG1355	regulation of microtubule-based process
TK1478	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TK1479	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
TK1481	COG0446	pyridine nucleotide-disulphide oxidoreductase
TK1482	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TK1486	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TK1489	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TK1491	COG1522	sequence-specific DNA binding
TK1494	COG1695	Transcriptional regulator
TK1496	COG0052	Belongs to the universal ribosomal protein uS2 family
TK1497	COG0148	phosphopyruvate hydratase activity
TK1500	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TK1501	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TK1503	COG0202	RNA polymerase activity
TK1505	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TK1506	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TK1507	COG2813	Specifically methylates the guanine in position
TK1509	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TK1511	COG1598	PFAM Uncharacterised protein family UPF0150
TK1512	COG1028	Short-chain dehydrogenase reductase Sdr
TK1514	COG1102	Psort location Cytoplasmic, score
TK1519	COG0200	Binds to the 23S rRNA
TK1520	COG1841	ribosomal large subunit assembly
TK1521	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TK1522	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TK1525	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TK1526	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TK1528	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TK1530	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TK1531	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TK1532	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TK1535	COG0255	Belongs to the universal ribosomal protein uL29 family
TK1536	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TK1538	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TK1539	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TK1540	COG0089	rRNA binding
TK1542	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TK1548	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TK1550	COG0017	Asparaginyl-tRNA synthetase
TK1551	COG0482	sulfurtransferase activity
TK1554	COG1215	transferase activity, transferring glycosyl groups
TK1556	COG0037	tRNA processing
TK1557	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
TK1558	COG0516	GMP reductase activity
TK1558	COG0517	IMP dehydrogenase activity
TK1559	COG0475	glutathione-regulated potassium exporter activity
TK1560	COG0475	glutathione-regulated potassium exporter activity
TK1561	COG2095	MarC family integral membrane protein
TK1567	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TK1568	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TK1572	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TK1590	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TK1594	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TK1595	COG0569	domain protein
TK1597	COG1269	ATP hydrolysis coupled proton transport
TK1599	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TK1601	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
TK1602	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TK1606	COG0840	transmembrane signaling receptor activity
TK1606	COG5278	phosphoserine phosphatase activity
TK1615	COG0430	RNA-3'-phosphate cyclase activity
TK1622	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TK1624	COG0511	ligase activity, forming carbon-carbon bonds
TK1624	COG5016	pyruvate
TK1625	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
TK1626	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TK1626	COG0517	IMP dehydrogenase activity
TK1633	COG1185	polyribonucleotide nucleotidyltransferase activity
TK1634	COG1185	polyribonucleotide nucleotidyltransferase activity
TK1637	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TK1643	COG1013	pyruvate-flavodoxin oxidoreductase activity
TK1650	COG1335	isochorismatase
TK1652	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TK1652	COG2050	protein possibly involved in aromatic compounds catabolism
TK1654	COG1695	Transcriptional regulator
TK1656	COG0252	asparaginase activity
TK1659	COG2095	MarC family integral membrane protein
TK1673	COG2890	protein-(glutamine-N5) methyltransferase activity
TK1677	COG1028	Short-chain dehydrogenase reductase Sdr
TK1684	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TK1684	COG0493	'glutamate synthase
TK1685	COG0543	2 iron, 2 sulfur cluster binding
TK1687	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TK1689	COG1404	Belongs to the peptidase S8 family
TK1693	COG2151	metal-sulfur cluster biosynthetic enzyme
TK1694	COG1141	Ferredoxin
TK1711	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TK1712	COG2244	polysaccharide biosynthetic process
TK1717	COG1216	Glycosyl transferase, family 2
TK1717	COG0463	Glycosyl transferase, family 2
TK1720	COG0463	Glycosyl transferase, family 2
TK1722	COG1442	glycosyl transferase family 8
TK1722	COG1216	Glycosyl transferase, family 2
TK1731	COG0438	transferase activity, transferring glycosyl groups
TK1733	COG0438	transferase activity, transferring glycosyl groups
TK1736	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TK1736	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TK1737	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
TK1738	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TK1747	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
TK1755	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TK1757	COG0444	Belongs to the ABC transporter superfamily
TK1759	COG0601	transmembrane transport
TK1768	COG0297	glycogen (starch) synthase activity
TK1769	COG1378	Sugar-specific transcriptional regulator TrmB
TK1773	COG3833	ABC-type maltose transport systems, permease component
TK1775	COG3842	ATPase activity
TK1777	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TK1778	COG1234	tRNA 3'-trailer cleavage
TK1779	COG1297	OPT oligopeptide transporter protein
TK1781	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TK1785	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TK1789	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TK1792	COG0697	spore germination
TK1796	COG0174	glutamine synthetase
TK1800	COG4608	Belongs to the ABC transporter superfamily
TK1801	COG0444	Belongs to the ABC transporter superfamily
TK1802	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TK1803	COG0601	transmembrane transport
TK1805	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TK1806	COG0543	2 iron, 2 sulfur cluster binding
TK1809	COG1449	Belongs to the glycosyl hydrolase 57 family
TK1813	COG0569	domain protein
TK1813	COG0475	glutathione-regulated potassium exporter activity
TK1817	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TK1820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TK1821	COG0037	tRNA processing
TK1822	COG1373	ATPase (AAA superfamily
TK1828	COG1085	galactose-1-phosphate uridylyltransferase
TK1831	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TK1836	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TK1840	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TK1843	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TK1846	COG0714	Associated with various cellular activities
TK1850	COG1047	Peptidyl-prolyl cis-trans
TK1857	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
TK1859	COG0577	efflux transmembrane transporter activity
TK1859	COG1136	(ABC) transporter
TK1861	COG4174	ABC transporter (Permease)
TK1863	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TK1863	COG0116	Belongs to the methyltransferase superfamily
TK1866	COG0573	inorganic phosphate transmembrane transporter activity
TK1868	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TK1870	COG0704	Plays a role in the regulation of phosphate uptake
TK1872	COG0179	Fumarylacetoacetate (FAA) hydrolase
TK1878	COG1234	tRNA 3'-trailer cleavage
TK1881	COG0640	Transcriptional regulator
TK1886	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TK1886	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TK1890	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TK1890	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TK1891	COG0402	S-adenosylhomocysteine deaminase activity
TK1893	COG2379	hydroxypyruvate reductase
TK1895	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TK1898	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
TK1900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TK1908	COG0095	Lipoate-protein ligase
TK1909	COG0463	Glycosyl transferase, family 2
TK1910	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TK1932	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TK1933	COG2264	protein methyltransferase activity
TK1940	COG0668	transmembrane transport
TK1954	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TK1955	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TK1963	COG0281	malic enzyme
TK1966	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TK1968	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
TK1970	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
TK1976	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TK1977	COG0306	phosphate transporter
TK1980	COG0674	pyruvate-flavodoxin oxidoreductase activity
TK1981	COG1013	pyruvate-flavodoxin oxidoreductase activity
TK1982	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TK1982	COG1144	Oxidoreductase
TK1983	COG0674	pyruvate-flavodoxin oxidoreductase activity
TK1984	COG1013	pyruvate-flavodoxin oxidoreductase activity
TK1990	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TK1993	COG0309	Hydrogenase expression formation protein (HypE)
TK1997	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
TK1999	COG1528	Iron-storage protein
TK2000	COG0409	Hydrogenase expression formation protein
TK2001	COG0298	carbon dioxide binding
TK2002	COG0746	molybdenum cofactor guanylyltransferase activity
TK2007	COG0489	protein tyrosine kinase activity
TK2008	COG0375	protein maturation
TK2009	COG1230	cation diffusion facilitator family transporter
TK2019	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TK2020	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TK2021	COG0489	protein tyrosine kinase activity
TK2026	COG1131	(ABC) transporter
TK2029	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TK2031	COG1254	Belongs to the acylphosphatase family
TK2033	COG1628	Protein of unknown function DUF99
TK2034	COG0589	response to stress
TK2035	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TK2037	COG0681	Belongs to the peptidase S26 family
TK2042	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TK2049	COG1506	peptidase
TK2049	COG4946	Tricorn protease homolog
TK2049	COG0823	Involved in the tonB-independent uptake of proteins
TK2053	COG1131	(ABC) transporter
TK2059	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TK2061	COG0306	phosphate transporter
TK2064	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TK2065	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TK2074	COG0493	'glutamate synthase
TK2075	COG0437	4 iron, 4 sulfur cluster binding
TK2076	COG3383	formate dehydrogenase (NAD+) activity
TK2077	COG0437	4 iron, 4 sulfur cluster binding
TK2078	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
TK2078	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
TK2079	COG2116	formate transmembrane transporter activity
TK2081	COG2212	antiporter activity
TK2082	COG1320	monovalent cation:proton antiporter activity
TK2087	COG0651	ATP synthesis coupled electron transport
TK2089	COG3260	NADH ubiquinone oxidoreductase 20
TK2090	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
TK2090	COG3261	NADH dehydrogenase
TK2092	COG0650	Formate hydrogenlyase subunit 4
TK2100	COG0492	ferredoxin-NADP+ reductase activity
TK2101	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TK2104	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TK2106	COG0148	phosphopyruvate hydratase activity
TK2110	COG1522	sequence-specific DNA binding
TK2115	COG0314	molybdopterin synthase activity
TK2124	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TK2126	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TK2130	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
TK2132	COG0235	Class ii aldolase
TK2134	COG1522	sequence-specific DNA binding
TK2137	COG2894	cell division
TK2138	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TK2142	COG1757	Na H antiporter
TK2143	COG1573	uracil-dna glycosylase
TK2145	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TK2147	COG0840	transmembrane signaling receptor activity
TK2149	COG1380	Effector of murein hydrolase LrgA
TK2150	COG1346	cytolysis
TK2160	COG0535	radical SAM domain protein
TK2161	COG1131	(ABC) transporter
TK2164	COG1980	fructose-bisphosphate aldolase activity
TK2169	COG0312	modulator of DNA gyrase
TK2179	COG0434	BtpA family
TK2195	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
TK2196	COG0540	Belongs to the ATCase OTCase family
TK2203	COG2078	PFAM AMMECR1 domain protein
TK2203	COG3885	ferrous iron binding
TK2209	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TK2211	COG0419	ATPase involved in DNA repair
TK2211	COG0419	ATPase involved in DNA repair
TK2213	COG0433	COG0433 Predicted ATPase
TK2214	COG0456	acetyltransferase
TK2217	COG0156	8-amino-7-oxononanoate synthase activity
TK2218	COG0305	Participates in initiation and elongation during chromosome replication
TK2218	COG1372	Participates in initiation and elongation during chromosome replication
TK2225	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TK2231	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TK2232	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TK2240	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
TK2241	COG2226	methyltransferase
TK2248	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TK2251	COG2271	Major facilitator Superfamily
TK2252	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TK2254	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TK2255	COG0546	phosphoglycolate phosphatase activity
TK2257	COG2131	deaminase
TK2258	COG0501	Belongs to the peptidase M48B family
TK2260	COG0167	dihydroorotate dehydrogenase activity
TK2263	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TK2267	COG2119	membrane
TK2271	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TK2272	COG1192	Involved in chromosome partitioning
TK2274	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TK2274	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TK2276	COG0284	orotidine-5'-phosphate decarboxylase activity
TK2279	COG1213	nucleotidyl transferase
TK2279	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TK2281	COG1131	(ABC) transporter
TK2290	COG1850	ribulose-bisphosphate carboxylase activity
TK2294	COG1851	Uncharacterised protein family (UPF0128)
TK2302	COG0585	pseudouridine synthase activity
TK2304	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TK2304	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA