locus-tag	class	description
TON_0001	COG0417	DNA replication proofreading
TON_0001	COG0417	DNA replication proofreading
TON_0007	COG1185	polyribonucleotide nucleotidyltransferase activity
TON_0011	COG1695	Transcriptional regulator
TON_0012	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TON_0012	COG2050	protein possibly involved in aromatic compounds catabolism
TON_0016	COG3842	ATPase activity
TON_0017	COG0628	permease
TON_0020	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TON_0030	COG1185	polyribonucleotide nucleotidyltransferase activity
TON_0031	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TON_0037	COG2239	Acts as a magnesium transporter
TON_0038	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
TON_0039	COG0511	ligase activity, forming carbon-carbon bonds
TON_0039	COG5016	pyruvate
TON_0041	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TON_0043	COG0305	Participates in initiation and elongation during chromosome replication
TON_0043	COG1372	Participates in initiation and elongation during chromosome replication
TON_0048	COG0430	RNA-3'-phosphate cyclase activity
TON_0054	COG0543	2 iron, 2 sulfur cluster binding
TON_0056	COG0543	2 iron, 2 sulfur cluster binding
TON_0057	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TON_0057	COG0493	'glutamate synthase
TON_0058	COG0017	Asparaginyl-tRNA synthetase
TON_0061	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TON_0066	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TON_0067	COG0088	Forms part of the polypeptide exit tunnel
TON_0068	COG0089	rRNA binding
TON_0069	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TON_0070	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TON_0071	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TON_0072	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TON_0073	COG0255	Belongs to the universal ribosomal protein uL29 family
TON_0074	COG0023	Translation Initiation Factor
TON_0075	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TON_0076	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TON_0079	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TON_0081	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TON_0082	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TON_0085	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TON_0086	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TON_0087	COG1841	ribosomal large subunit assembly
TON_0088	COG0200	Binds to the 23S rRNA
TON_0093	COG1102	Psort location Cytoplasmic, score
TON_0095	COG0300	oxidoreductase activity
TON_0096	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TON_0101	COG2813	Specifically methylates the guanine in position
TON_0102	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TON_0103	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TON_0106	COG0200	Binds to the 23S rRNA
TON_0107	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TON_0108	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TON_0112	COG0052	Belongs to the universal ribosomal protein uS2 family
TON_0118	COG1522	sequence-specific DNA binding
TON_0120	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TON_0123	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TON_0128	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TON_0129	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TON_0131	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
TON_0132	COG1355	regulation of microtubule-based process
TON_0133	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TON_0135	COG1304	FMN binding
TON_0136	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TON_0137	COG0142	geranyltranstransferase activity
TON_0141	COG0495	leucyl-tRNA aminoacylation
TON_0147	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
TON_0150	COG0864	Transcriptional regulator
TON_0153	COG1543	Belongs to the glycosyl hydrolase 57 family
TON_0154	COG0347	Belongs to the P(II) protein family
TON_0156	COG0733	neurotransmitter:sodium symporter activity
TON_0157	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TON_0164	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TON_0165	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TON_0168	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TON_0176	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TON_0179	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TON_0180	COG0081	regulation of translation
TON_0184	COG0717	Belongs to the dCTP deaminase family
TON_0189	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TON_0191	COG0058	SHG alpha-glucan phosphorylase activity
TON_0192	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
TON_0193	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TON_0196	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TON_0200	COG0584	glycerophosphoryl diester phosphodiesterase
TON_0201	COG0584	glycerophosphoryl diester phosphodiesterase
TON_0203	COG0579	oxidoreductase
TON_0214	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TON_0217	COG0085	RNA polymerase activity
TON_0218	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TON_0219	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TON_0223	COG0049	tRNA binding
TON_0224	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TON_0231	COG0436	Aminotransferase
TON_0237	COG1185	polyribonucleotide nucleotidyltransferase activity
TON_0240	COG0310	cobalt ion transport
TON_0243	COG1122	ATPase activity
TON_0247	COG2140	Oxalate decarboxylase
TON_0248	COG1994	Peptidase M50
TON_0252	COG1234	tRNA 3'-trailer cleavage
TON_0254	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TON_0255	COG4139	cobalamin transport
TON_0262	COG0489	protein tyrosine kinase activity
TON_0264	COG0746	molybdenum cofactor guanylyltransferase activity
TON_0266	COG0651	ATP synthesis coupled electron transport
TON_0271	COG1320	monovalent cation:proton antiporter activity
TON_0274	COG3260	NADH ubiquinone oxidoreductase 20
TON_0275	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TON_0276	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
TON_0276	COG3261	NADH dehydrogenase
TON_0277	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TON_0278	COG0651	ATP synthesis coupled electron transport
TON_0279	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TON_0281	COG3383	formate dehydrogenase (NAD+) activity
TON_0284	COG0409	Hydrogenase expression formation protein
TON_0285	COG0409	Hydrogenase expression formation protein
TON_0286	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
TON_0289	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TON_0290	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TON_0298	COG1120	ATPase activity
TON_0305	COG0446	pyridine nucleotide-disulphide oxidoreductase
TON_0308	COG1404	Belongs to the peptidase S8 family
TON_0311	COG0574	Belongs to the PEP-utilizing enzyme family
TON_0311	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TON_0312	COG0534	Mate efflux family protein
TON_0313	COG0534	Mate efflux family protein
TON_0314	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TON_0315	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TON_0320	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TON_0331	COG1110	DNA topoisomerase II activity
TON_0336	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
TON_0341	COG1418	mRNA catabolic process
TON_0343	COG0017	Asparaginyl-tRNA synthetase
TON_0346	COG0585	pseudouridine synthase activity
TON_0348	COG1473	amidohydrolase
TON_0352	COG0504	CTP synthase activity
TON_0356	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TON_0359	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TON_0361	COG0517	IMP dehydrogenase activity
TON_0361	COG0516	GMP reductase activity
TON_0362	COG0024	Methionine aminopeptidase
TON_0363	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TON_0364	COG1122	ATPase activity
TON_0373	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TON_0376	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TON_0377	COG1185	polyribonucleotide nucleotidyltransferase activity
TON_0385	COG0628	permease
TON_0386	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TON_0391	COG1131	(ABC) transporter
TON_0393	COG0556	nucleotide-excision repair
TON_0394	COG0101	tRNA pseudouridine synthase activity
TON_0395	COG0072	phenylalanine-tRNA ligase activity
TON_0397	COG1063	alcohol dehydrogenase
TON_0398	COG2894	cell division
TON_0402	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TON_0403	COG0252	asparaginase activity
TON_0409	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TON_0411	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TON_0417	COG0438	transferase activity, transferring glycosyl groups
TON_0419	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TON_0425	COG0010	Belongs to the arginase family
TON_0435	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TON_0437	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TON_0439	COG1757	Na H antiporter
TON_0442	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TON_0443	COG0656	L-ascorbic acid biosynthetic process
TON_0446	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TON_0446	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TON_0449	COG0359	binds to the 23S rRNA
TON_0449	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
TON_0458	COG0602	queuosine metabolic process
TON_0462	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TON_0476	COG1151	hydroxylamine reductase activity
TON_0487	COG0649	NAD binding
TON_0488	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TON_0489	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TON_0490	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TON_0492	COG0651	ATP synthesis coupled electron transport
TON_0493	COG1006	Multisubunit Na H antiporter MnhC subunit
TON_0494	COG2111	Na H antiporter
TON_0494	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TON_0496	COG1320	monovalent cation:proton antiporter activity
TON_0497	COG2212	antiporter activity
TON_0498	COG1863	multisubunit Na H antiporter MnhE subunit
TON_0500	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TON_0502	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TON_0505	COG0018	arginyl-trna synthetase
TON_0506	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TON_0521	COG0301	tRNA thio-modification
TON_0521	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TON_0522	COG1836	PFAM Integral membrane protein DUF92
TON_0523	COG1522	sequence-specific DNA binding
TON_0529	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TON_0530	COG0396	ATPase activity
TON_0531	COG0719	Fe-S assembly protein
TON_0535	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
TON_0538	COG2116	formate transmembrane transporter activity
TON_0539	COG3383	formate dehydrogenase (NAD+) activity
TON_0540	COG0437	4 iron, 4 sulfur cluster binding
TON_0541	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TON_0542	COG0493	'glutamate synthase
TON_0543	COG0437	4 iron, 4 sulfur cluster binding
TON_0546	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TON_0548	COG1476	TRANSCRIPTIONal
TON_0558	COG1515	deoxyribonuclease V activity
TON_0560	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
TON_0562	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TON_0565	COG0436	Aminotransferase
TON_0566	COG2192	nodulation
TON_0568	COG0442	prolyl-tRNA aminoacylation
TON_0569	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TON_0571	COG0730	response to heat
TON_0573	COG0730	response to heat
TON_0580	COG0720	synthase
TON_0583	COG1013	pyruvate-flavodoxin oxidoreductase activity
TON_0584	COG0674	pyruvate-flavodoxin oxidoreductase activity
TON_0584	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TON_0586	COG1013	pyruvate-flavodoxin oxidoreductase activity
TON_0587	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TON_0587	COG0674	pyruvate-flavodoxin oxidoreductase activity
TON_0590	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TON_0594	COG1744	ABC transporter substrate-binding protein PnrA-like
TON_0601	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
TON_0602	COG0215	cysteine-tRNA ligase activity
TON_0606	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TON_0607	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TON_0608	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TON_0608	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TON_0609	COG0307	riboflavin synthase, alpha
TON_0610	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TON_0610	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TON_0611	COG1505	serine-type exopeptidase activity
TON_0612	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TON_0613	COG1201	RNA secondary structure unwinding
TON_0613	COG1201	RNA secondary structure unwinding
TON_0615	COG1215	transferase activity, transferring glycosyl groups
TON_0616	COG0306	phosphate transporter
TON_0627	COG1363	Peptidase, m42
TON_0635	COG2096	Adenosyltransferase
TON_0637	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TON_0638	COG1058	Belongs to the CinA family
TON_0638	COG1546	Belongs to the CinA family
TON_0640	COG0814	amino acid
TON_0641	COG1872	DUF167
TON_0643	COG0423	glycine-tRNA ligase activity
TON_0646	COG0534	Mate efflux family protein
TON_0648	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
TON_0651	COG0006	proline dipeptidase activity
TON_0654	COG0482	sulfurtransferase activity
TON_0659	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
TON_0661	COG0163	prenyltransferase activity
TON_0666	COG0012	GTP binding
TON_0668	COG0598	Magnesium transport protein CorA
TON_0669	COG1794	racemase activity, acting on amino acids and derivatives
TON_0671	COG0312	modulator of DNA gyrase
TON_0673	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TON_0677	COG0525	valine-tRNA ligase activity
TON_0678	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TON_0679	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TON_0684	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TON_0685	COG2342	PFAM TM1410 hypothetical-related protein
TON_0686	COG0746	molybdenum cofactor guanylyltransferase activity
TON_0687	COG1492	cobalamin metabolic process
TON_0691	COG0303	'Molybdopterin
TON_0696	COG1078	dGTPase activity
TON_0701	COG1899	peptidyl-lysine modification to peptidyl-hypusine
TON_0703	COG1028	Short-chain dehydrogenase reductase Sdr
TON_0707	COG0459	protein refolding
TON_0709	COG0515	serine threonine protein kinase
TON_0710	COG0840	transmembrane signaling receptor activity
TON_0711	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TON_0713	COG0315	cyclic pyranopterin monophosphate synthase activity
TON_0718	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TON_0719	COG1215	transferase activity, transferring glycosyl groups
TON_0724	COG1739	Uncharacterized protein family UPF0029
TON_0725	COG1205	dead DEAH box helicase
TON_0725	COG1111	helicase
TON_0727	COG1121	(ABC) transporter
TON_0743	COG2403	cyclic 2,3-diphosphoglycerate synthetase activity
TON_0748	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TON_0749	COG2414	aldehyde ferredoxin oxidoreductase
TON_0751	COG0051	transcription antitermination factor activity, RNA binding
TON_0752	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TON_0755	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TON_0756	COG1078	dGTPase activity
TON_0757	COG1469	GTP cyclohydrolase I activity
TON_0764	COG2205	protein histidine kinase activity
TON_0768	COG1121	(ABC) transporter
TON_0770	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TON_0774	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TON_0777	COG2226	methyltransferase
TON_0780	COG0563	adenylate kinase activity
TON_0783	COG0531	amino acid
TON_0786	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TON_0795	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TON_0796	COG1993	acr, cog1993
TON_0799	COG0668	transmembrane transport
TON_0801	COG1794	racemase activity, acting on amino acids and derivatives
TON_0804	COG0312	modulator of DNA gyrase
TON_0805	COG0312	modulator of DNA gyrase
TON_0807	COG0477	Major facilitator Superfamily
TON_0814	COG0438	transferase activity, transferring glycosyl groups
TON_0817	COG0546	phosphoglycolate phosphatase activity
TON_0819	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TON_0821	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TON_0828	COG0243	molybdopterin cofactor binding
TON_0829	COG0450	alkyl hydroperoxide reductase
TON_0834	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TON_0835	COG2217	Heavy metal translocating P-type atpase
TON_0838	COG2226	methyltransferase
TON_0840	COG2217	Heavy metal translocating P-type atpase
TON_0846	COG0672	)-iron permease
TON_0847	COG0450	alkyl hydroperoxide reductase
TON_0851	COG0396	ATPase activity
TON_0853	COG0301	tRNA thio-modification
TON_0854	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TON_0855	COG0778	Nitroreductase
TON_0861	COG1013	pyruvate-flavodoxin oxidoreductase activity
TON_0862	COG0450	alkyl hydroperoxide reductase
TON_0863	COG0426	domain, Protein
TON_0866	COG1592	Rubrerythrin
TON_0867	COG1773	rubredoxin
TON_0868	COG2033	superoxide reductase activity
TON_0879	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TON_0881	COG0131	Imidazoleglycerol-phosphate dehydratase
TON_0882	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TON_0883	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TON_0884	COG0107	imidazoleglycerol-phosphate synthase activity
TON_0885	COG0140	phosphoribosyl-ATP diphosphatase activity
TON_0885	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TON_0886	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TON_0888	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TON_0889	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TON_0893	COG1353	crispr-associated protein
TON_0895	COG1337	RAMP superfamily
TON_0899	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TON_0901	COG1301	dicarboxylic acid transport
TON_0905	COG1966	Carbon starvation protein
TON_0910	COG2267	carboxylic ester hydrolase activity
TON_0911	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TON_0916	COG0489	protein tyrosine kinase activity
TON_0923	COG1028	Short-chain dehydrogenase reductase Sdr
TON_0928	COG1342	Belongs to the UPF0251 family
TON_0929	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TON_0934	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TON_0937	COG1201	RNA secondary structure unwinding
TON_0938	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TON_0939	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TON_0941	COG0084	hydrolase, TatD family'
TON_0945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TON_0946	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TON_0947	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TON_0948	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TON_0951	COG0105	UTP biosynthetic process
TON_0957	COG0175	sulfate reduction
TON_0960	COG0402	S-adenosylhomocysteine deaminase activity
TON_0961	COG0017	Asparaginyl-tRNA synthetase
TON_0963	COG4143	(ABC) transporter
TON_0968	COG1444	tRNA N-acetyltransferase activity
TON_0969	COG1506	peptidase
TON_0969	COG0823	Involved in the tonB-independent uptake of proteins
TON_0969	COG4946	Tricorn protease homolog
TON_0973	COG1268	BioY protein
TON_0974	COG1122	ATPase activity
TON_0975	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TON_0980	COG1522	sequence-specific DNA binding
TON_0984	COG1178	ABC-type Fe3 transport system permease component
TON_0985	COG3842	ATPase activity
TON_0987	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TON_0990	COG0126	phosphoglycerate kinase activity
TON_0996	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TON_1002	COG1042	CoA-binding domain protein
TON_1002	COG0045	succinate-CoA ligase (ADP-forming) activity
TON_1002	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TON_1004	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TON_1006	COG0301	tRNA thio-modification
TON_1008	COG0301	tRNA thio-modification
TON_1015	COG1489	DNA binding
TON_1017	COG0437	4 iron, 4 sulfur cluster binding
TON_1019	COG2894	cell division
TON_1021	COG0651	ATP synthesis coupled electron transport
TON_1022	COG0650	Formate hydrogenlyase subunit 4
TON_1023	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
TON_1023	COG3261	NADH dehydrogenase
TON_1024	COG3260	NADH ubiquinone oxidoreductase 20
TON_1026	COG1320	monovalent cation:proton antiporter activity
TON_1028	COG2111	Na H antiporter
TON_1029	COG1006	Multisubunit Na H antiporter MnhC subunit
TON_1031	COG0651	ATP synthesis coupled electron transport
TON_1040	COG1199	ATP-dependent helicase activity
TON_1042	COG0513	Belongs to the DEAD box helicase family
TON_1045	COG0483	inositol monophosphate 1-phosphatase activity
TON_1047	COG1979	alcohol dehydrogenase
TON_1049	COG1984	allophanate hydrolase subunit 2
TON_1050	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TON_1051	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TON_1055	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TON_1058	COG0330	HflC and HflK could
TON_1059	COG2894	cell division
TON_1062	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
TON_1065	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
TON_1069	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TON_1071	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TON_1072	COG1196	nuclear chromosome segregation
TON_1076	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TON_1076	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TON_1078	COG0424	maF-like protein
TON_1080	COG4956	integral membrane protein (PIN domain superfamily)
TON_1081	COG2894	cell division
TON_1083	COG0367	asparagine synthase
TON_1086	COG0009	L-threonylcarbamoyladenylate synthase
TON_1090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TON_1091	COG0303	'Molybdopterin
TON_1094	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TON_1097	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TON_1097	COG1042	CoA-binding domain protein
TON_1097	COG0045	succinate-CoA ligase (ADP-forming) activity
TON_1113	COG0071	Belongs to the small heat shock protein (HSP20) family
TON_1128	COG0778	Nitroreductase
TON_1132	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TON_1133	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TON_1134	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TON_1136	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TON_1138	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TON_1140	COG1605	Chorismate mutase
TON_1140	COG0077	Prephenate dehydratase
TON_1156	COG2226	methyltransferase
TON_1161	COG0560	Phosphoserine phosphatase
TON_1164	COG1051	belongs to the nudix hydrolase family
TON_1164	COG1056	cytidyltransferase-related domain
TON_1175	COG0560	Phosphoserine phosphatase
TON_1176	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TON_1190	COG2264	protein methyltransferase activity
TON_1193	COG0835	chemotaxis
TON_1194	COG0840	transmembrane signaling receptor activity
TON_1196	COG2201	protein-glutamate methylesterase activity
TON_1197	COG2201	protein-glutamate methylesterase activity
TON_1198	COG2198	Histidine kinase
TON_1198	COG0643	Histidine kinase
TON_1201	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
TON_1211	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
TON_1212	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TON_1217	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TON_1218	COG0432	Pfam Uncharacterised protein family UPF0047
TON_1228	COG2379	hydroxypyruvate reductase
TON_1232	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TON_1233	COG1435	thymidine kinase activity
TON_1234	COG1850	ribulose-bisphosphate carboxylase activity
TON_1243	COG1131	(ABC) transporter
TON_1248	COG1213	nucleotidyl transferase
TON_1248	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TON_1251	COG0284	orotidine-5'-phosphate decarboxylase activity
TON_1253	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TON_1253	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TON_1255	COG1192	Involved in chromosome partitioning
TON_1256	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TON_1260	COG2119	membrane
TON_1263	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TON_1264	COG0167	dihydroorotate dehydrogenase activity
TON_1268	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TON_1271	COG0446	pyridine nucleotide-disulphide oxidoreductase
TON_1276	COG0501	Belongs to the peptidase M48B family
TON_1279	COG2814	Major facilitator Superfamily
TON_1280	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TON_1283	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TON_1284	COG1522	sequence-specific DNA binding
TON_1285	COG0693	protein deglycase activity
TON_1291	COG2095	MarC family integral membrane protein
TON_1292	COG1765	OsmC-like protein
TON_1295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TON_1296	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TON_1301	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TON_1310	COG0123	including yeast histone deacetylase and acetoin utilization protein
TON_1314	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TON_1321	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TON_1322	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TON_1325	COG0440	acetolactate synthase activity
TON_1326	COG0651	ATP synthesis coupled electron transport
TON_1332	COG2212	antiporter activity
TON_1333	COG1863	multisubunit Na H antiporter MnhE subunit
TON_1334	COG0509	glycine decarboxylation via glycine cleavage system
TON_1336	COG0493	'glutamate synthase
TON_1337	COG0543	2 iron, 2 sulfur cluster binding
TON_1348	COG1131	(ABC) transporter
TON_1349	COG1476	TRANSCRIPTIONal
TON_1353	COG0535	radical SAM domain protein
TON_1354	COG2414	aldehyde ferredoxin oxidoreductase
TON_1355	COG1404	Belongs to the peptidase S8 family
TON_1360	COG2151	metal-sulfur cluster biosynthetic enzyme
TON_1361	COG1141	Ferredoxin
TON_1368	COG2131	deaminase
TON_1369	COG0501	Belongs to the peptidase M48B family
TON_1375	COG0543	2 iron, 2 sulfur cluster binding
TON_1376	COG0493	'glutamate synthase
TON_1385	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TON_1386	COG0477	Major facilitator Superfamily
TON_1391	COG2814	Major facilitator Superfamily
TON_1392	COG1446	asparaginase
TON_1397	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
TON_1403	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TON_1407	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TON_1410	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TON_1414	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TON_1415	COG0156	8-amino-7-oxononanoate synthase activity
TON_1418	COG1214	PFAM Peptidase M22, glycoprotease
TON_1418	COG0456	acetyltransferase
TON_1420	COG0433	COG0433 Predicted ATPase
TON_1422	COG0419	ATPase involved in DNA repair
TON_1422	COG0419	ATPase involved in DNA repair
TON_1424	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TON_1425	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TON_1426	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TON_1428	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TON_1431	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TON_1436	COG0351	phosphomethylpyrimidine kinase
TON_1436	COG1992	Thiamine-phosphate synthase
TON_1437	COG0540	Belongs to the ATCase OTCase family
TON_1438	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
TON_1445	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TON_1449	COG0434	BtpA family
TON_1454	COG0312	modulator of DNA gyrase
TON_1455	COG0640	Transcriptional regulator
TON_1458	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TON_1463	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TON_1465	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
TON_1466	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
TON_1470	COG0475	glutathione-regulated potassium exporter activity
TON_1474	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TON_1475	COG0306	phosphate transporter
TON_1478	COG0674	pyruvate-flavodoxin oxidoreductase activity
TON_1479	COG1013	pyruvate-flavodoxin oxidoreductase activity
TON_1481	COG0674	pyruvate-flavodoxin oxidoreductase activity
TON_1482	COG1013	pyruvate-flavodoxin oxidoreductase activity
TON_1483	COG0489	protein tyrosine kinase activity
TON_1488	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TON_1490	COG1254	Belongs to the acylphosphatase family
TON_1492	COG1628	Protein of unknown function DUF99
TON_1493	COG0589	response to stress
TON_1494	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TON_1497	COG1980	fructose-bisphosphate aldolase activity
TON_1501	COG1233	COG1233 Phytoene dehydrogenase and related
TON_1510	COG1522	sequence-specific DNA binding
TON_1511	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TON_1513	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TON_1517	COG1757	Na H antiporter
TON_1518	COG1573	uracil-dna glycosylase
TON_1520	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TON_1523	COG1380	Effector of murein hydrolase LrgA
TON_1524	COG1346	cytolysis
TON_1527	COG0235	Class ii aldolase
TON_1529	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
TON_1532	COG0095	Lipoate-protein ligase
TON_1533	COG0681	Belongs to the peptidase S26 family
TON_1543	COG0823	Involved in the tonB-independent uptake of proteins
TON_1543	COG1506	peptidase
TON_1543	COG4946	Tricorn protease homolog
TON_1552	COG0306	phosphate transporter
TON_1557	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TON_1558	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TON_1559	COG3259	Nickel-dependent hydrogenase
TON_1562	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TON_1563	COG3383	formate dehydrogenase (NAD+) activity
TON_1564	COG0437	4 iron, 4 sulfur cluster binding
TON_1565	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TON_1566	COG0651	ATP synthesis coupled electron transport
TON_1567	COG0651	ATP synthesis coupled electron transport
TON_1568	COG0650	Formate hydrogenlyase subunit 4
TON_1569	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
TON_1569	COG3261	NADH dehydrogenase
TON_1570	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TON_1571	COG3260	NADH ubiquinone oxidoreductase 20
TON_1573	COG2116	formate transmembrane transporter activity
TON_1575	COG1320	monovalent cation:proton antiporter activity
TON_1577	COG2111	Na H antiporter
TON_1578	COG1006	Multisubunit Na H antiporter MnhC subunit
TON_1580	COG0651	ATP synthesis coupled electron transport
TON_1581	COG0746	molybdenum cofactor guanylyltransferase activity
TON_1582	COG1863	multisubunit Na H antiporter MnhE subunit
TON_1583	COG2212	antiporter activity
TON_1584	COG1320	monovalent cation:proton antiporter activity
TON_1589	COG0651	ATP synthesis coupled electron transport
TON_1591	COG3260	NADH ubiquinone oxidoreductase 20
TON_1592	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
TON_1592	COG3261	NADH dehydrogenase
TON_1594	COG0650	Formate hydrogenlyase subunit 4
TON_1603	COG0492	ferredoxin-NADP+ reductase activity
TON_1605	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TON_1608	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TON_1611	COG2814	Major facilitator Superfamily
TON_1612	COG0535	radical SAM domain protein
TON_1613	COG0148	phosphopyruvate hydratase activity
TON_1615	COG1522	sequence-specific DNA binding
TON_1616	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TON_1620	COG0314	molybdopterin synthase activity
TON_1622	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TON_1630	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TON_1630	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TON_1632	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TON_1634	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TON_1646	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TON_1651	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TON_1653	COG0402	S-adenosylhomocysteine deaminase activity
TON_1655	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TON_1655	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TON_1659	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TON_1659	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TON_1663	COG0640	Transcriptional regulator
TON_1664	COG0490	domain, Protein
TON_1664	COG0471	metal ion transport
TON_1666	COG0180	Tryptophanyl-tRNA synthetase
TON_1667	COG0179	Fumarylacetoacetate (FAA) hydrolase
TON_1671	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TON_1671	COG0116	Belongs to the methyltransferase superfamily
TON_1672	COG1160	GTP binding
TON_1678	COG1047	Peptidyl-prolyl cis-trans
TON_1683	COG0714	Associated with various cellular activities
TON_1686	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TON_1687	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TON_1689	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TON_1690	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TON_1694	COG0750	zinc metalloprotease
TON_1695	COG0463	Glycosyl transferase, family 2
TON_1695	COG1216	Glycosyl transferase, family 2
TON_1696	COG3119	arylsulfatase activity
TON_1699	COG0110	maltose O-acetyltransferase activity
TON_1700	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TON_1701	COG1086	Polysaccharide biosynthesis protein
TON_1703	COG0730	response to heat
TON_1707	COG2046	Belongs to the sulfate adenylyltransferase family
TON_1709	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TON_1716	COG1449	Belongs to the glycosyl hydrolase 57 family
TON_1717	COG0037	tRNA processing
TON_1719	COG2239	Acts as a magnesium transporter
TON_1720	COG0475	glutathione-regulated potassium exporter activity
TON_1729	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TON_1732	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TON_1740	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TON_1742	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TON_1745	COG0569	domain protein
TON_1747	COG1269	ATP hydrolysis coupled proton transport
TON_1749	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TON_1751	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
TON_1752	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TON_1754	COG1394	ATPase activity, coupled to movement of substances
TON_1755	COG0426	domain, Protein
TON_1755	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TON_1756	COG0840	transmembrane signaling receptor activity
TON_1756	COG5278	phosphoserine phosphatase activity
TON_1757	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TON_1763	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TON_1765	COG0601	transmembrane transport
TON_1766	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TON_1767	COG0444	Belongs to the ABC transporter superfamily
TON_1768	COG4608	Belongs to the ABC transporter superfamily
TON_1772	COG0174	glutamine synthetase
TON_1776	COG0697	spore germination
TON_1779	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TON_1783	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TON_1785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TON_1787	COG1297	OPT oligopeptide transporter protein
TON_1791	COG3842	ATPase activity
TON_1793	COG3833	ABC-type maltose transport systems, permease component
TON_1794	COG1175	transmembrane transport
TON_1795	COG2182	Extracellular solute-binding protein
TON_1797	COG1378	Sugar-specific transcriptional regulator TrmB
TON_1798	COG0297	glycogen (starch) synthase activity
TON_1805	COG0697	spore germination
TON_1807	COG2414	aldehyde ferredoxin oxidoreductase
TON_1813	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TON_1816	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TON_1821	COG0438	transferase activity, transferring glycosyl groups
TON_1831	COG0714	Associated with various cellular activities
TON_1837	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TON_1855	COG0297	glycogen (starch) synthase activity
TON_1855	COG0438	transferase activity, transferring glycosyl groups
TON_1856	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TON_1857	COG0438	transferase activity, transferring glycosyl groups
TON_1860	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TON_1862	COG1216	Glycosyl transferase, family 2
TON_1874	COG1120	ATPase activity
TON_1876	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
TON_1884	COG0516	GMP reductase activity
TON_1884	COG0517	IMP dehydrogenase activity
TON_1885	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TON_1887	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TON_1889	COG0157	Belongs to the NadC ModD family
TON_1890	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TON_1893	COG0519	Catalyzes the synthesis of GMP from XMP
TON_1893	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TON_1894	COG0519	Catalyzes the synthesis of GMP from XMP
TON_1894	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TON_1906	COG2264	protein methyltransferase activity
TON_1913	COG0539	negative regulation of cytoplasmic translation
TON_1919	COG2234	aminopeptidase activity
TON_1923	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TON_1931	COG1695	Transcriptional regulator
TON_1933	COG0393	Putative heavy-metal-binding
TON_1935	COG2264	protein methyltransferase activity
TON_1939	COG0668	transmembrane transport
TON_1948	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TON_1950	COG0109	protoheme IX farnesyltransferase activity
TON_1957	COG2252	PERMEase
TON_1959	COG1178	ABC-type Fe3 transport system permease component
TON_1964	COG0011	TIGRFAM Protein of
TON_1965	COG2078	PFAM AMMECR1 domain protein
TON_1966	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TON_1966	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TON_1968	COG1335	isochorismatase
TON_1973	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TON_1976	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair