locus-tag	class	description
TES1_0007	COG0714	Associated with various cellular activities
TES1_0014	COG0647	UMP catabolic process
TES1_0020	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
TES1_0021	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TES1_0037	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
TES1_0044	COG1543	Belongs to the glycosyl hydrolase 57 family
TES1_0045	COG0347	Belongs to the P(II) protein family
TES1_0047	COG0733	neurotransmitter:sodium symporter activity
TES1_0048	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TES1_0050	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TES1_0051	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TES1_0054	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TES1_0056	COG0022	dehydrogenase e1 component
TES1_0057	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TES1_0058	COG0508	dehydrogenase complex catalyzes the overall conversion of
TES1_0059	COG0508	dehydrogenase complex catalyzes the overall conversion of
TES1_0061	COG3199	ATP-NAD kinase
TES1_0062	COG0095	Lipoate-protein ligase
TES1_0063	COG0534	Mate efflux family protein
TES1_0064	COG0574	Belongs to the PEP-utilizing enzyme family
TES1_0064	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TES1_0068	COG1473	amidohydrolase
TES1_0069	COG1404	Belongs to the peptidase S8 family
TES1_0076	COG0446	pyridine nucleotide-disulphide oxidoreductase
TES1_0078	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TES1_0083	COG1618	nucleotide phosphatase activity, acting on free nucleotides
TES1_0084	COG1120	ATPase activity
TES1_0089	COG0731	radical SAM domain protein
TES1_0089	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TES1_0093	COG0409	Hydrogenase expression formation protein
TES1_0095	COG1309	transcriptional regulator
TES1_0096	COG3383	formate dehydrogenase (NAD+) activity
TES1_0098	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TES1_0099	COG0651	ATP synthesis coupled electron transport
TES1_0100	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TES1_0101	COG3261	NADH dehydrogenase
TES1_0101	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
TES1_0102	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TES1_0103	COG3260	NADH ubiquinone oxidoreductase 20
TES1_0106	COG1320	monovalent cation:proton antiporter activity
TES1_0109	COG1006	Multisubunit Na H antiporter MnhC subunit
TES1_0111	COG0651	ATP synthesis coupled electron transport
TES1_0115	COG1120	ATPase activity
TES1_0117	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
TES1_0121	COG1063	alcohol dehydrogenase
TES1_0122	COG0746	molybdenum cofactor guanylyltransferase activity
TES1_0125	COG1234	tRNA 3'-trailer cleavage
TES1_0128	COG1994	Peptidase M50
TES1_0129	COG2140	Oxalate decarboxylase
TES1_0134	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TES1_0138	COG1122	ATPase activity
TES1_0141	COG0310	cobalt ion transport
TES1_0143	COG0025	NhaP-type Na H and K H
TES1_0144	COG0010	Belongs to the arginase family
TES1_0148	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TES1_0150	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TES1_0150	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TES1_0151	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TES1_0152	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TES1_0154	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TES1_0158	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TES1_0160	COG0017	Asparaginyl-tRNA synthetase
TES1_0161	COG0778	Nitroreductase
TES1_0162	COG0493	'glutamate synthase
TES1_0162	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TES1_0163	COG0543	2 iron, 2 sulfur cluster binding
TES1_0165	COG0543	2 iron, 2 sulfur cluster binding
TES1_0167	COG3259	Nickel-dependent hydrogenase
TES1_0173	COG0430	RNA-3'-phosphate cyclase activity
TES1_0179	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TES1_0181	COG0511	ligase activity, forming carbon-carbon bonds
TES1_0181	COG5016	pyruvate
TES1_0182	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
TES1_0183	COG2239	Acts as a magnesium transporter
TES1_0184	COG0460	homoserine dehydrogenase
TES1_0191	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TES1_0193	COG0089	rRNA binding
TES1_0194	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TES1_0195	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TES1_0197	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TES1_0198	COG0255	Belongs to the universal ribosomal protein uL29 family
TES1_0199	COG0023	Translation Initiation Factor
TES1_0201	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TES1_0202	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TES1_0203	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TES1_0205	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TES1_0207	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TES1_0208	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TES1_0211	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TES1_0213	COG1841	ribosomal large subunit assembly
TES1_0214	COG0200	Binds to the 23S rRNA
TES1_0219	COG1102	Psort location Cytoplasmic, score
TES1_0221	COG1028	Short-chain dehydrogenase reductase Sdr
TES1_0222	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TES1_0223	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TES1_0224	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TES1_0225	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TES1_0227	COG0200	Binds to the 23S rRNA
TES1_0228	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TES1_0229	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TES1_0232	COG0148	phosphopyruvate hydratase activity
TES1_0233	COG0052	Belongs to the universal ribosomal protein uS2 family
TES1_0234	COG1355	regulation of microtubule-based process
TES1_0236	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TES1_0237	COG1304	FMN binding
TES1_0238	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TES1_0241	COG0495	leucyl-tRNA aminoacylation
TES1_0246	COG0626	cystathionine gamma-synthase activity
TES1_0252	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
TES1_0254	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TES1_0258	COG1185	polyribonucleotide nucleotidyltransferase activity
TES1_0267	COG0359	binds to the 23S rRNA
TES1_0267	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
TES1_0270	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TES1_0270	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TES1_0271	COG0656	L-ascorbic acid biosynthetic process
TES1_0280	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TES1_0283	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TES1_0288	COG0717	Belongs to the dCTP deaminase family
TES1_0293	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TES1_0299	COG0058	SHG alpha-glucan phosphorylase activity
TES1_0301	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TES1_0304	COG2271	Major facilitator Superfamily
TES1_0305	COG2211	Major facilitator Superfamily
TES1_0306	COG0584	glycerophosphoryl diester phosphodiesterase
TES1_0307	COG0584	glycerophosphoryl diester phosphodiesterase
TES1_0311	COG0579	oxidoreductase
TES1_0321	COG0288	reversible hydration of carbon dioxide
TES1_0324	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TES1_0327	COG0085	RNA polymerase activity
TES1_0328	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TES1_0329	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TES1_0333	COG0049	tRNA binding
TES1_0334	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TES1_0336	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TES1_0337	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
TES1_0338	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TES1_0341	COG0477	Major facilitator Superfamily
TES1_0342	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TES1_0345	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TES1_0347	COG1522	sequence-specific DNA binding
TES1_0351	COG1695	Transcriptional regulator
TES1_0361	COG0003	Pfam Anion-transporting ATPase
TES1_0363	COG1966	Carbon starvation protein
TES1_0364	COG0511	ligase activity, forming carbon-carbon bonds
TES1_0364	COG5016	pyruvate
TES1_0365	COG1830	Aldolase
TES1_0366	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
TES1_0366	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
TES1_0369	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TES1_0370	COG1872	DUF167
TES1_0372	COG0423	glycine-tRNA ligase activity
TES1_0376	COG0534	Mate efflux family protein
TES1_0378	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
TES1_0380	COG0006	proline dipeptidase activity
TES1_0382	COG0709	Synthesizes selenophosphate from selenide and ATP
TES1_0383	COG0482	sulfurtransferase activity
TES1_0386	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TES1_0386	COG1918	ferrous iron import across plasma membrane
TES1_0388	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TES1_0390	COG0163	prenyltransferase activity
TES1_0391	COG1522	sequence-specific DNA binding
TES1_0395	COG0012	GTP binding
TES1_0398	COG0598	Magnesium transport protein CorA
TES1_0402	COG0312	modulator of DNA gyrase
TES1_0403	COG0312	modulator of DNA gyrase
TES1_0407	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TES1_0414	COG0243	molybdopterin cofactor binding
TES1_0415	COG0450	alkyl hydroperoxide reductase
TES1_0421	COG1013	pyruvate-flavodoxin oxidoreductase activity
TES1_0422	COG0450	alkyl hydroperoxide reductase
TES1_0423	COG0426	domain, Protein
TES1_0424	COG0446	pyridine nucleotide-disulphide oxidoreductase
TES1_0425	COG1592	Rubrerythrin
TES1_0426	COG1773	rubredoxin
TES1_0427	COG2033	superoxide reductase activity
TES1_0433	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TES1_0444	COG1185	polyribonucleotide nucleotidyltransferase activity
TES1_0449	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TES1_0454	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TES1_0461	COG0252	asparaginase activity
TES1_0462	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TES1_0466	COG2894	cell division
TES1_0467	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TES1_0468	COG1063	alcohol dehydrogenase
TES1_0469	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TES1_0472	COG0101	tRNA pseudouridine synthase activity
TES1_0473	COG0556	nucleotide-excision repair
TES1_0475	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TES1_0477	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TES1_0478	COG0083	homoserine kinase activity
TES1_0479	COG0527	aspartate kinase activity
TES1_0481	COG3959	Transketolase, thiamine diphosphate binding domain
TES1_0482	COG3958	Transketolase
TES1_0483	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TES1_0486	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TES1_0487	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TES1_0488	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TES1_0491	COG0436	Aminotransferase
TES1_0493	COG2217	Heavy metal translocating P-type atpase
TES1_0495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TES1_0496	COG0347	Belongs to the P(II) protein family
TES1_0497	COG0004	ammonium transporteR
TES1_0498	COG0137	argininosuccinate synthase activity
TES1_0499	COG0165	Argininosuccinate lyase
TES1_0500	COG0505	Belongs to the CarA family
TES1_0502	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TES1_0503	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TES1_0504	COG0066	3-isopropylmalate dehydratase activity
TES1_0505	COG0473	3-isopropylmalate dehydrogenase activity
TES1_0507	COG0189	ligase activity
TES1_0508	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TES1_0510	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TES1_0511	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TES1_0513	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TES1_0514	COG0140	phosphoribosyl-ATP diphosphatase activity
TES1_0514	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TES1_0515	COG0107	imidazoleglycerol-phosphate synthase activity
TES1_0516	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TES1_0517	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TES1_0518	COG0131	Imidazoleglycerol-phosphate dehydratase
TES1_0520	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TES1_0524	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TES1_0527	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TES1_0529	COG3842	ATPase activity
TES1_0530	COG0395	ABC-type sugar transport system, permease component
TES1_0531	COG1175	transmembrane transport
TES1_0538	COG0725	ABC transporter, periplasmic molybdate-binding protein
TES1_0539	COG4149	molybdate abc transporter
TES1_0540	COG3842	ATPase activity
TES1_0542	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TES1_0543	COG1546	Belongs to the CinA family
TES1_0543	COG1058	Belongs to the CinA family
TES1_0544	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TES1_0546	COG1794	racemase activity, acting on amino acids and derivatives
TES1_0548	COG1993	acr, cog1993
TES1_0549	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TES1_0564	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TES1_0565	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TES1_0567	COG0156	8-amino-7-oxononanoate synthase activity
TES1_0570	COG0456	acetyltransferase
TES1_0570	COG1214	PFAM Peptidase M22, glycoprotease
TES1_0571	COG0433	COG0433 Predicted ATPase
TES1_0573	COG0419	ATPase involved in DNA repair
TES1_0573	COG0419	ATPase involved in DNA repair
TES1_0575	COG0343	queuine tRNA-ribosyltransferase activity
TES1_0576	COG0306	phosphate transporter
TES1_0577	COG1215	transferase activity, transferring glycosyl groups
TES1_0579	COG0470	DNA polymerase III
TES1_0579	COG1067	ATP-dependent peptidase activity
TES1_0586	COG1694	Mazg nucleotide pyrophosphohydrolase
TES1_0587	COG1522	sequence-specific DNA binding
TES1_0588	COG1836	PFAM Integral membrane protein DUF92
TES1_0589	COG0552	protein localization to endoplasmic reticulum
TES1_0590	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
TES1_0591	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
TES1_0592	COG0352	thiamine-phosphate diphosphorylase activity
TES1_0593	COG0351	phosphomethylpyrimidine kinase
TES1_0594	COG1121	(ABC) transporter
TES1_0596	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TES1_0598	COG2890	protein-(glutamine-N5) methyltransferase activity
TES1_0601	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TES1_0602	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TES1_0605	COG2226	methyltransferase
TES1_0612	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TES1_0613	COG0644	oxidoreductase
TES1_0615	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TES1_0622	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TES1_0628	COG1131	(ABC) transporter
TES1_0631	COG0084	hydrolase, TatD family'
TES1_0633	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TES1_0634	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TES1_0638	COG1201	RNA secondary structure unwinding
TES1_0640	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TES1_0643	COG1120	ATPase activity
TES1_0644	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TES1_0653	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TES1_0657	COG1013	pyruvate-flavodoxin oxidoreductase activity
TES1_0658	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TES1_0658	COG0674	pyruvate-flavodoxin oxidoreductase activity
TES1_0660	COG1013	pyruvate-flavodoxin oxidoreductase activity
TES1_0661	COG0674	pyruvate-flavodoxin oxidoreductase activity
TES1_0661	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TES1_0665	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TES1_0666	COG2095	MarC family integral membrane protein
TES1_0670	COG2205	protein histidine kinase activity
TES1_0675	COG1469	GTP cyclohydrolase I activity
TES1_0679	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TES1_0684	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TES1_0685	COG1850	ribulose-bisphosphate carboxylase activity
TES1_0686	COG1435	thymidine kinase activity
TES1_0692	COG2379	hydroxypyruvate reductase
TES1_0696	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TES1_0697	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TES1_0698	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TES1_0699	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TES1_0700	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TES1_0701	COG4821	SIS domain
TES1_0707	COG1832	CoA-binding protein
TES1_0713	COG1160	GTP binding
TES1_0715	COG1418	mRNA catabolic process
TES1_0716	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TES1_0720	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TES1_0723	COG2414	aldehyde ferredoxin oxidoreductase
TES1_0734	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TES1_0735	COG0726	polysaccharide deacetylase
TES1_0736	COG0438	transferase activity, transferring glycosyl groups
TES1_0744	COG0730	response to heat
TES1_0745	COG0469	pyruvate kinase activity
TES1_0751	COG1110	DNA topoisomerase II activity
TES1_0756	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
TES1_0761	COG1418	mRNA catabolic process
TES1_0763	COG0017	Asparaginyl-tRNA synthetase
TES1_0766	COG0585	pseudouridine synthase activity
TES1_0767	COG0561	phosphatase activity
TES1_0768	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TES1_0777	COG1122	ATPase activity
TES1_0778	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TES1_0779	COG0402	S-adenosylhomocysteine deaminase activity
TES1_0780	COG0024	Methionine aminopeptidase
TES1_0781	COG2239	Acts as a magnesium transporter
TES1_0783	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TES1_0784	COG1968	undecaprenyl-diphosphatase activity
TES1_0785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TES1_0787	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TES1_0792	COG0504	CTP synthase activity
TES1_0814	COG0312	modulator of DNA gyrase
TES1_0815	COG0312	modulator of DNA gyrase
TES1_0816	COG0720	synthase
TES1_0822	COG0601	transmembrane transport
TES1_0823	COG0730	response to heat
TES1_0824	COG0730	response to heat
TES1_0825	COG1363	Peptidase, m42
TES1_0826	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TES1_0827	COG0442	prolyl-tRNA aminoacylation
TES1_0828	COG2192	nodulation
TES1_0829	COG0436	Aminotransferase
TES1_0832	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TES1_0835	COG2226	methyltransferase
TES1_0837	COG0525	valine-tRNA ligase activity
TES1_0841	COG0864	Transcriptional regulator
TES1_0844	COG1881	PFAM PEBP family protein
TES1_0850	COG0475	glutathione-regulated potassium exporter activity
TES1_0852	COG0822	iron-sulfur transferase activity
TES1_0856	COG1151	hydroxylamine reductase activity
TES1_0859	COG0006	proline dipeptidase activity
TES1_0860	COG0672	)-iron permease
TES1_0866	COG0649	NAD binding
TES1_0867	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TES1_0868	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TES1_0869	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TES1_0871	COG0651	ATP synthesis coupled electron transport
TES1_0873	COG2111	Na H antiporter
TES1_0873	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TES1_0875	COG1320	monovalent cation:proton antiporter activity
TES1_0876	COG2212	antiporter activity
TES1_0877	COG1863	multisubunit Na H antiporter MnhE subunit
TES1_0879	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TES1_0882	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TES1_0887	COG0018	arginyl-trna synthetase
TES1_0889	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TES1_0901	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TES1_0907	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TES1_0913	COG0616	signal peptide processing
TES1_0915	COG0628	permease
TES1_0917	COG1121	(ABC) transporter
TES1_0918	COG1111	helicase
TES1_0918	COG1205	dead DEAH box helicase
TES1_0923	COG0163	prenyltransferase activity
TES1_0924	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TES1_0925	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TES1_0926	COG0051	transcription antitermination factor activity, RNA binding
TES1_0928	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TES1_0934	COG1131	(ABC) transporter
TES1_0937	COG0315	cyclic pyranopterin monophosphate synthase activity
TES1_0938	COG1193	negative regulation of DNA recombination
TES1_0939	COG0515	serine threonine protein kinase
TES1_0941	COG0459	protein refolding
TES1_0945	COG1078	dGTPase activity
TES1_0953	COG0501	Belongs to the peptidase M48B family
TES1_0954	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TES1_0956	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
TES1_0958	COG1515	deoxyribonuclease V activity
TES1_0962	COG0569	domain protein
TES1_0964	COG1476	TRANSCRIPTIONal
TES1_0967	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TES1_0968	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TES1_0970	COG1492	cobalamin metabolic process
TES1_0971	COG2342	PFAM TM1410 hypothetical-related protein
TES1_0973	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TES1_0978	COG1573	uracil-dna glycosylase
TES1_0980	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TES1_0983	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TES1_0984	COG0437	4 iron, 4 sulfur cluster binding
TES1_0985	COG0493	'glutamate synthase
TES1_0989	COG1201	RNA secondary structure unwinding
TES1_0992	COG1505	serine-type exopeptidase activity
TES1_0993	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
TES1_0996	COG1047	Peptidyl-prolyl cis-trans
TES1_0997	COG0215	cysteine-tRNA ligase activity
TES1_0999	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TES1_1003	COG0803	Belongs to the bacterial solute-binding protein 9 family
TES1_1007	COG1744	ABC transporter substrate-binding protein PnrA-like
TES1_1009	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TES1_1010	COG1518	maintenance of DNA repeat elements
TES1_1022	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TES1_1027	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
TES1_1030	COG1446	asparaginase
TES1_1031	COG2814	Major facilitator Superfamily
TES1_1035	COG2271	Major facilitator Superfamily
TES1_1036	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TES1_1038	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TES1_1041	COG2131	deaminase
TES1_1042	COG0501	Belongs to the peptidase M48B family
TES1_1049	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TES1_1057	COG0733	neurotransmitter:sodium symporter activity
TES1_1058	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TES1_1060	COG0693	protein deglycase activity
TES1_1065	COG1765	OsmC-like protein
TES1_1067	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TES1_1069	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TES1_1072	COG4670	ketone body catabolic process
TES1_1074	COG0517	IMP dehydrogenase activity
TES1_1074	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TES1_1077	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TES1_1078	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TES1_1078	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TES1_1079	COG0489	protein tyrosine kinase activity
TES1_1080	COG0489	protein tyrosine kinase activity
TES1_1083	COG1342	Belongs to the UPF0251 family
TES1_1091	COG0513	Belongs to the DEAD box helicase family
TES1_1095	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
TES1_1098	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
TES1_1100	COG0330	HflC and HflK could
TES1_1103	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TES1_1110	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TES1_1111	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TES1_1112	COG1984	allophanate hydrolase subunit 2
TES1_1114	COG0371	Dehydrogenase
TES1_1116	COG0483	inositol monophosphate 1-phosphatase activity
TES1_1118	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TES1_1119	COG1196	nuclear chromosome segregation
TES1_1123	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TES1_1123	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TES1_1124	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TES1_1125	COG0424	maF-like protein
TES1_1127	COG2894	cell division
TES1_1129	COG0367	asparagine synthase
TES1_1131	COG0438	transferase activity, transferring glycosyl groups
TES1_1132	COG0009	L-threonylcarbamoyladenylate synthase
TES1_1135	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
TES1_1136	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TES1_1140	COG2267	carboxylic ester hydrolase activity
TES1_1142	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TES1_1145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TES1_1160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TES1_1160	COG0045	succinate-CoA ligase (ADP-forming) activity
TES1_1160	COG1042	CoA-binding domain protein
TES1_1163	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TES1_1165	COG0303	'Molybdopterin
TES1_1166	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TES1_1173	COG0105	UTP biosynthetic process
TES1_1174	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TES1_1176	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TES1_1177	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TES1_1178	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TES1_1181	COG1213	nucleotidyl transferase
TES1_1181	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TES1_1184	COG3842	ATPase activity
TES1_1185	COG0395	ABC-type sugar transport system, permease component
TES1_1193	COG1199	ATP-dependent helicase activity
TES1_1197	COG0651	ATP synthesis coupled electron transport
TES1_1199	COG1006	Multisubunit Na H antiporter MnhC subunit
TES1_1200	COG2111	Na H antiporter
TES1_1202	COG1320	monovalent cation:proton antiporter activity
TES1_1204	COG3260	NADH ubiquinone oxidoreductase 20
TES1_1205	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TES1_1206	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
TES1_1206	COG3261	NADH dehydrogenase
TES1_1207	COG0650	Formate hydrogenlyase subunit 4
TES1_1208	COG0651	ATP synthesis coupled electron transport
TES1_1210	COG0003	Pfam Anion-transporting ATPase
TES1_1211	COG1151	hydroxylamine reductase activity
TES1_1212	COG0437	4 iron, 4 sulfur cluster binding
TES1_1215	COG1489	DNA binding
TES1_1220	COG0778	Nitroreductase
TES1_1222	COG0301	tRNA thio-modification
TES1_1223	COG0301	tRNA thio-modification
TES1_1230	COG1042	CoA-binding domain protein
TES1_1230	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TES1_1230	COG0045	succinate-CoA ligase (ADP-forming) activity
TES1_1234	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TES1_1237	COG1131	(ABC) transporter
TES1_1240	COG0126	phosphoglycerate kinase activity
TES1_1245	COG1178	ABC-type Fe3 transport system permease component
TES1_1249	COG0513	Belongs to the DEAD box helicase family
TES1_1251	COG0017	Asparaginyl-tRNA synthetase
TES1_1252	COG0402	S-adenosylhomocysteine deaminase activity
TES1_1256	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TES1_1270	COG1056	cytidyltransferase-related domain
TES1_1270	COG1051	belongs to the nudix hydrolase family
TES1_1275	COG0454	-acetyltransferase
TES1_1280	COG2226	methyltransferase
TES1_1295	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TES1_1303	COG0588	phosphoglycerate mutase activity
TES1_1304	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TES1_1305	COG0071	Belongs to the small heat shock protein (HSP20) family
TES1_1310	COG2119	membrane
TES1_1314	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TES1_1315	COG1192	Involved in chromosome partitioning
TES1_1317	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TES1_1317	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TES1_1320	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TES1_1320	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TES1_1321	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TES1_1321	COG1793	dna ligase
TES1_1327	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TES1_1328	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TES1_1333	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TES1_1334	COG0183	Belongs to the thiolase family
TES1_1342	COG0123	including yeast histone deacetylase and acetoin utilization protein
TES1_1346	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TES1_1350	COG0535	radical SAM domain protein
TES1_1351	COG2414	aldehyde ferredoxin oxidoreductase
TES1_1354	COG1141	Ferredoxin
TES1_1355	COG1141	Ferredoxin
TES1_1356	COG2151	metal-sulfur cluster biosynthetic enzyme
TES1_1360	COG1402	creatininase
TES1_1361	COG0438	transferase activity, transferring glycosyl groups
TES1_1365	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TES1_1366	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TES1_1375	COG1320	monovalent cation:proton antiporter activity
TES1_1376	COG2212	antiporter activity
TES1_1377	COG1863	multisubunit Na H antiporter MnhE subunit
TES1_1378	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
TES1_1379	COG0309	Hydrogenase expression formation protein (HypE)
TES1_1384	COG0489	protein tyrosine kinase activity
TES1_1390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TES1_1391	COG2217	Heavy metal translocating P-type atpase
TES1_1396	COG0626	cystathionine gamma-synthase activity
TES1_1399	COG2217	Heavy metal translocating P-type atpase
TES1_1400	COG2217	Heavy metal translocating P-type atpase
TES1_1408	COG0396	ATPase activity
TES1_1409	COG0301	tRNA thio-modification
TES1_1410	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TES1_1411	COG1528	Iron-storage protein
TES1_1414	COG0432	Pfam Uncharacterised protein family UPF0047
TES1_1416	COG1992	Thiamine-phosphate synthase
TES1_1416	COG0351	phosphomethylpyrimidine kinase
TES1_1420	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TES1_1426	COG0237	dephospho-CoA kinase activity
TES1_1429	COG0434	BtpA family
TES1_1438	COG0312	modulator of DNA gyrase
TES1_1439	COG0312	modulator of DNA gyrase
TES1_1443	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TES1_1451	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TES1_1452	COG0650	Formate hydrogenlyase subunit 4
TES1_1454	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TES1_1454	COG0649	NAD binding
TES1_1455	COG3260	NADH ubiquinone oxidoreductase 20
TES1_1457	COG0651	ATP synthesis coupled electron transport
TES1_1458	COG1006	Multisubunit Na H antiporter MnhC subunit
TES1_1462	COG1320	monovalent cation:proton antiporter activity
TES1_1463	COG2212	antiporter activity
TES1_1466	COG0650	Formate hydrogenlyase subunit 4
TES1_1468	COG3261	NADH dehydrogenase
TES1_1468	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
TES1_1469	COG3260	NADH ubiquinone oxidoreductase 20
TES1_1471	COG0651	ATP synthesis coupled electron transport
TES1_1472	COG1006	Multisubunit Na H antiporter MnhC subunit
TES1_1476	COG1320	monovalent cation:proton antiporter activity
TES1_1477	COG2212	antiporter activity
TES1_1478	COG1863	multisubunit Na H antiporter MnhE subunit
TES1_1479	COG0651	ATP synthesis coupled electron transport
TES1_1481	COG1006	Multisubunit Na H antiporter MnhC subunit
TES1_1482	COG2111	Na H antiporter
TES1_1484	COG1320	monovalent cation:proton antiporter activity
TES1_1486	COG2116	formate transmembrane transporter activity
TES1_1488	COG3260	NADH ubiquinone oxidoreductase 20
TES1_1489	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TES1_1490	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
TES1_1490	COG3261	NADH dehydrogenase
TES1_1491	COG0650	Formate hydrogenlyase subunit 4
TES1_1492	COG0651	ATP synthesis coupled electron transport
TES1_1493	COG0651	ATP synthesis coupled electron transport
TES1_1494	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TES1_1495	COG0437	4 iron, 4 sulfur cluster binding
TES1_1496	COG3383	formate dehydrogenase (NAD+) activity
TES1_1497	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TES1_1500	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TES1_1501	COG3259	Nickel-dependent hydrogenase
TES1_1502	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TES1_1503	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TES1_1504	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TES1_1507	COG1476	TRANSCRIPTIONal
TES1_1508	COG1131	(ABC) transporter
TES1_1519	COG0543	2 iron, 2 sulfur cluster binding
TES1_1520	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TES1_1520	COG0493	'glutamate synthase
TES1_1522	COG0509	glycine decarboxylation via glycine cleavage system
TES1_1525	COG1254	Belongs to the acylphosphatase family
TES1_1527	COG1628	Protein of unknown function DUF99
TES1_1528	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TES1_1531	COG2255	four-way junction helicase activity
TES1_1533	COG0492	ferredoxin-NADP+ reductase activity
TES1_1534	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TES1_1536	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TES1_1539	COG0148	phosphopyruvate hydratase activity
TES1_1540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TES1_1543	COG1131	(ABC) transporter
TES1_1548	COG0489	protein tyrosine kinase activity
TES1_1549	COG1013	pyruvate-flavodoxin oxidoreductase activity
TES1_1550	COG0674	pyruvate-flavodoxin oxidoreductase activity
TES1_1552	COG1013	pyruvate-flavodoxin oxidoreductase activity
TES1_1553	COG0674	pyruvate-flavodoxin oxidoreductase activity
TES1_1554	COG1144	Oxidoreductase
TES1_1557	COG0306	phosphate transporter
TES1_1558	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TES1_1560	COG0475	glutathione-regulated potassium exporter activity
TES1_1564	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
TES1_1566	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
TES1_1568	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TES1_1570	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
TES1_1570	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
TES1_1575	COG0589	response to stress
TES1_1576	COG1136	(ABC) transporter
TES1_1578	COG1136	(ABC) transporter
TES1_1578	COG0577	efflux transmembrane transporter activity
TES1_1579	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TES1_1584	COG1451	nucleotide metabolic process
TES1_1596	COG0395	ABC-type sugar transport system, permease component
TES1_1597	COG1175	transmembrane transport
TES1_1603	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TES1_1604	COG4608	Belongs to the ABC transporter superfamily
TES1_1605	COG0444	Belongs to the ABC transporter superfamily
TES1_1607	COG0601	transmembrane transport
TES1_1608	COG0747	negative chemotaxis
TES1_1612	COG0281	malic enzyme
TES1_1613	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TES1_1618	COG2252	PERMEase
TES1_1621	COG0235	Class ii aldolase
TES1_1629	COG0011	TIGRFAM Protein of
TES1_1630	COG2078	PFAM AMMECR1 domain protein
TES1_1631	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TES1_1631	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TES1_1632	COG0417	DNA replication proofreading
TES1_1643	COG1695	Transcriptional regulator
TES1_1644	COG2050	protein possibly involved in aromatic compounds catabolism
TES1_1644	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TES1_1647	COG1335	isochorismatase
TES1_1654	COG0442	prolyl-tRNA aminoacylation
TES1_1656	COG0297	glycogen (starch) synthase activity
TES1_1657	COG1378	Sugar-specific transcriptional regulator TrmB
TES1_1659	COG2182	Extracellular solute-binding protein
TES1_1660	COG1175	transmembrane transport
TES1_1661	COG3833	ABC-type maltose transport systems, permease component
TES1_1663	COG3842	ATPase activity
TES1_1666	COG1234	tRNA 3'-trailer cleavage
TES1_1667	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TES1_1669	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TES1_1674	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TES1_1677	COG0697	spore germination
TES1_1682	COG0174	glutamine synthetase
TES1_1686	COG4608	Belongs to the ABC transporter superfamily
TES1_1687	COG0444	Belongs to the ABC transporter superfamily
TES1_1688	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TES1_1689	COG0601	transmembrane transport
TES1_1694	COG0519	Catalyzes the synthesis of GMP from XMP
TES1_1694	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TES1_1695	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TES1_1698	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TES1_1701	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TES1_1703	COG1269	ATP hydrolysis coupled proton transport
TES1_1705	COG0569	domain protein
TES1_1706	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TES1_1708	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TES1_1710	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TES1_1715	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TES1_1718	COG1115	amino acid carrier protein
TES1_1721	COG0124	histidyl-tRNA synthetase
TES1_1723	COG2264	protein methyltransferase activity
TES1_1734	COG2234	aminopeptidase activity
TES1_1735	COG0463	Glycosyl transferase, family 2
TES1_1738	COG4143	(ABC) transporter
TES1_1742	COG1444	tRNA N-acetyltransferase activity
TES1_1743	COG0823	Involved in the tonB-independent uptake of proteins
TES1_1743	COG1506	peptidase
TES1_1743	COG4946	Tricorn protease homolog
TES1_1744	COG1196	nuclear chromosome segregation
TES1_1749	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
TES1_1751	COG1268	BioY protein
TES1_1752	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
TES1_1752	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
TES1_1754	COG1122	ATPase activity
TES1_1755	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TES1_1759	COG1111	helicase
TES1_1759	COG1205	dead DEAH box helicase
TES1_1761	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TES1_1765	COG0306	phosphate transporter
TES1_1770	COG4946	Tricorn protease homolog
TES1_1770	COG1506	peptidase
TES1_1770	COG0823	Involved in the tonB-independent uptake of proteins
TES1_1774	COG0681	Belongs to the peptidase S26 family
TES1_1784	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TES1_1791	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TES1_1793	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TES1_1804	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TES1_1806	COG0501	Belongs to the peptidase M48B family
TES1_1811	COG0314	molybdopterin synthase activity
TES1_1815	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TES1_1816	COG1522	sequence-specific DNA binding
TES1_1818	COG1980	fructose-bisphosphate aldolase activity
TES1_1822	COG3842	ATPase activity
TES1_1827	COG0673	inositol 2-dehydrogenase activity
TES1_1828	COG0463	Glycosyl transferase, family 2
TES1_1835	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
TES1_1838	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TES1_1839	COG0402	S-adenosylhomocysteine deaminase activity
TES1_1840	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TES1_1840	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TES1_1841	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TES1_1841	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TES1_1844	COG0640	Transcriptional regulator
TES1_1845	COG0471	metal ion transport
TES1_1845	COG0490	domain, Protein
TES1_1849	COG0179	Fumarylacetoacetate (FAA) hydrolase
TES1_1851	COG0116	Belongs to the methyltransferase superfamily
TES1_1851	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TES1_1852	COG1160	GTP binding
TES1_1859	COG1047	Peptidyl-prolyl cis-trans
TES1_1864	COG0714	Associated with various cellular activities
TES1_1868	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TES1_1872	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TES1_1881	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TES1_1885	COG1216	Glycosyl transferase, family 2
TES1_1885	COG1442	glycosyl transferase family 8
TES1_1889	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TES1_1891	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TES1_1893	COG4651	solute:proton antiporter activity
TES1_1893	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TES1_1899	COG1449	Belongs to the glycosyl hydrolase 57 family
TES1_1901	COG0037	tRNA processing
TES1_1903	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
TES1_1905	COG0475	glutathione-regulated potassium exporter activity
TES1_1906	COG0475	glutathione-regulated potassium exporter activity
TES1_1907	COG1522	sequence-specific DNA binding
TES1_1910	COG1793	dna ligase
TES1_1913	COG2189	Belongs to the N(4) N(6)-methyltransferase family
TES1_1914	COG1757	Na H antiporter
TES1_1915	COG1573	uracil-dna glycosylase
TES1_1917	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TES1_1921	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TES1_1924	COG0395	ABC-type sugar transport system, permease component
TES1_1925	COG1175	transmembrane transport
TES1_1927	COG0438	transferase activity, transferring glycosyl groups
TES1_1930	COG1380	Effector of murein hydrolase LrgA
TES1_1931	COG1346	cytolysis
TES1_1935	COG0668	transmembrane transport
TES1_1952	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TES1_1954	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TES1_1955	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TES1_1962	COG0539	negative regulation of cytoplasmic translation
TES1_1968	COG2890	protein-(glutamine-N5) methyltransferase activity
TES1_1980	COG0519	Catalyzes the synthesis of GMP from XMP
TES1_1980	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TES1_1981	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TES1_1981	COG0519	Catalyzes the synthesis of GMP from XMP
TES1_1982	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
TES1_1984	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TES1_1987	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TES1_1988	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TES1_1988	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TES1_1989	COG0307	riboflavin synthase, alpha
TES1_1990	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TES1_1990	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TES1_1991	COG0516	GMP reductase activity
TES1_1991	COG0517	IMP dehydrogenase activity
TES1_1996	COG1328	CTP reductase activity
TES1_1998	COG1785	Belongs to the alkaline phosphatase family
TES1_2001	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
TES1_2007	COG2046	Belongs to the sulfate adenylyltransferase family
TES1_2013	COG0730	response to heat
TES1_2028	COG1368	sulfuric ester hydrolase activity
TES1_2032	COG0438	transferase activity, transferring glycosyl groups
TES1_2034	COG0438	transferase activity, transferring glycosyl groups
TES1_2034	COG0297	glycogen (starch) synthase activity
TES1_2036	COG1216	Glycosyl transferase, family 2
TES1_2037	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity