locus-tag	class	description
TSIB_0005	ENOG4107R8N	Glycosyl transferase, family 2
TSIB_0006	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
TSIB_0010	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
TSIB_0023	ENOG4105D4U	had-superfamily hydrolase, subfamily iia
TSIB_0025	ENOG4105F0N	pyrophosphate phospho-hydrolase
TSIB_0026	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
TSIB_0031	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
TSIB_0035	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
TSIB_0044	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
TSIB_0047	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
TSIB_0048	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
TSIB_0053	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
TSIB_0054	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
TSIB_0055	ENOG4108IYU	L-aspartate oxidase
TSIB_0056	ENOG4108JIU	phosphoribosylformylglycinamidine synthase ii
TSIB_0057	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
TSIB_0060	ENOG4107QNG	Phosphoribosylglycinamide synthetase
TSIB_0063	ENOG4108HH9	Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR
TSIB_0064	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
TSIB_0065	ENOG4105C8V	SAICAR synthetase
TSIB_0067	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
TSIB_0072	ENOG4105D64	Mechanosensitive ion channel
TSIB_0073	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
TSIB_0079	ENOG4105CUT	histidyl-tRNA synthetase
TSIB_0085	ENOG41067MG	lrgb family
TSIB_0086	ENOG4105VAW	lrga family
TSIB_0087	ENOG4105KME	endoribonuclease L-psp
TSIB_0089	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
TSIB_0091	ENOG4105CND	Glycosyl transferase, family 2
TSIB_0093	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
TSIB_0096	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
TSIB_0098	ENOG4105KEG	ribosomal-protein-alanine acetyltransferase
TSIB_0100	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
TSIB_0101	ENOG4105C6E	dna polymerase iii
TSIB_0105	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
TSIB_0107	ENOG4105EVI	UPF0374 protein
TSIB_0108	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
TSIB_0109	ENOG4107WCI	zn-dependent hydrolase of the beta-lactamase fold-like protein
TSIB_0113	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
TSIB_0119	ENOG4105DK7	lysyl-tRNA synthetase
TSIB_0122	ENOG4105C7N	Xanthine uracil vitamin C permease
TSIB_0123	ENOG4105C6K	Malic enzyme
TSIB_0126	ENOG4108JVH	Protein of unknown function DUF43
TSIB_0127	ENOG4105VG1	fes assembly suf system protein
TSIB_0128	ENOG41084T3	4fe-4S ferredoxin iron-sulfur binding domain-containing protein
TSIB_0129	ENOG41084T3	4fe-4S ferredoxin iron-sulfur binding domain-containing protein
TSIB_0133	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
TSIB_0137	ENOG4105CN9	Peptidase m42 family protein
TSIB_0141	ENOG4105DA5	(ABC) transporter
TSIB_0142	ENOG4105CJ1	ABC, transporter
TSIB_0148	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
TSIB_0151	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
TSIB_0157	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
TSIB_0161	ENOG41066FR	extracellular solute-binding protein
TSIB_0162	ENOG4105E0C	molybdate abc transporter
TSIB_0163	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
TSIB_0165	ENOG4107QRT	dEAD DEAH box helicase
TSIB_0173	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
TSIB_0174	ENOG4105C8N	cysteinyl-tRNA synthetase
TSIB_0175	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
TSIB_0175	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
TSIB_0176	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
TSIB_0181	ENOG4108JQ9	ABC transporter
TSIB_0182	ENOG4105DIH	basic membrane
TSIB_0184	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
TSIB_0186	ENOG4105DXX	methyltransferase
TSIB_0198	ENOG4107ZCS	Phosphomethylpyrimidine kinase
TSIB_0200	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
TSIB_0201	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
TSIB_0206	ENOG4105CD5	CoA-binding domain protein
TSIB_0210	ENOG4105CSM	endonuclease III
TSIB_0215	ENOG4105BZA	Phosphoglycerate kinase
TSIB_0221	ENOG4107RCV	ABC transporter, permease
TSIB_0225	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
TSIB_0229	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
TSIB_0230	ENOG41061GT	Aldolase
TSIB_0231	ENOG4107QSA	Oxaloacetate decarboxylase
TSIB_0232	ENOG4105D22	carbon starvation protein
TSIB_0238	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
TSIB_0246	ENOG4105CYW	agmatinase
TSIB_0248	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
TSIB_0250	ENOG4108ZFX	Mannosyl-3-phosphoglycerate phosphatase
TSIB_0253	ENOG4107T0X	DNA ligase
TSIB_0254	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
TSIB_0258	ENOG4105C8T	Leucyl-tRNA synthetase
TSIB_0263	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
TSIB_0267	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
TSIB_0268	ENOG4105CH2	amidohydrolase
TSIB_0276	ENOG4105D44	asparaginase
TSIB_0277	ENOG4105C6X	Major Facilitator
TSIB_0278	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
TSIB_0281	ENOG4105DJB	Major Facilitator Superfamily
TSIB_0283	ENOG4107SHJ	sulfite reductase subunit b
TSIB_0288	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
TSIB_0290	ENOG41080UE	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
TSIB_0291	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TSIB_0292	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
TSIB_0293	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
TSIB_0295	ENOG41082SA	50s ribosomal protein l29
TSIB_0298	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
TSIB_0299	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
TSIB_0300	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
TSIB_0302	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TSIB_0304	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
TSIB_0305	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
TSIB_0308	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
TSIB_0309	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
TSIB_0311	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
TSIB_0316	ENOG4108Z4J	Cytidine monophosphate kinase
TSIB_0318	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
TSIB_0319	ENOG4105EMU	Dehydrogenase
TSIB_0324	ENOG4105CS2	ec 3.2.1.21
TSIB_0330	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
TSIB_0331	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
TSIB_0337	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
TSIB_0338	ENOG4107Y49	methyltransferase
TSIB_0339	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TSIB_0340	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
TSIB_0341	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
TSIB_0344	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
TSIB_0345	ENOG4108UJD	30S ribosomal protein S9
TSIB_0348	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
TSIB_0349	ENOG4105CE9	30S ribosomal protein S2
TSIB_0351	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
TSIB_0353	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
TSIB_0355	ENOG4105C6T	cysteine synthase
TSIB_0358	ENOG4105XN3	extracellular solute-binding protein family 1
TSIB_0359	ENOG4105EQ7	Binding-protein-dependent transport systems, inner membrane component
TSIB_0360	ENOG4105EB1	binding-protein-dependent transport systems inner membrane Component
TSIB_0361	ENOG41088YS	Glycosyl transferase (Group 1
TSIB_0367	ENOG4105ECW	sulfate abc transporter
TSIB_0368	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
TSIB_0369	ENOG4105DP9	ABC transporter
TSIB_0371	ENOG4108T9Q	UPF0278 protein
TSIB_0379	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
TSIB_0382	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
TSIB_0383	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
TSIB_0386	ENOG4105DHP	deoxycytidine triphosphate deaminase
TSIB_0388	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
TSIB_0390	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
TSIB_0394	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
TSIB_0397	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
TSIB_0401	ENOG4108I5U	Uridine phosphorylase
TSIB_0409	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TSIB_0410	ENOG41081FY	multiple antibiotic resistance (MarC)-related
TSIB_0411	ENOG4105DIK	(ABC) transporter
TSIB_0413	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
TSIB_0417	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
TSIB_0428	ENOG4108VA3	3-hexulose-6-phosphate synthase
TSIB_0435	ENOG4105C5S	asparaginyl-tRNA synthetase
TSIB_0438	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
TSIB_0440	ENOG4105SKN	orotidine 5''-phosphate decarboxylase
TSIB_0441	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
TSIB_0443	ENOG4105CD3	dihydroorotase
TSIB_0444	ENOG4108R9M	Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity)
TSIB_0445	ENOG4105CXT	aspartate transcarbamylase
TSIB_0446	ENOG4107YIW	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
TSIB_0448	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
TSIB_0449	ENOG4108VVK	transcriptional Regulator, AsnC
TSIB_0450	ENOG4107RWR	Sodium hydrogen exchanger
TSIB_0451	ENOG4107RWR	Sodium hydrogen exchanger
TSIB_0453	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
TSIB_0454	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
TSIB_0455	ENOG4105C6W	4-alpha-glucanotransferase (EC 2.4.1.25)
TSIB_0459	ENOG4107RWR	Sodium hydrogen exchanger
TSIB_0462	ENOG4105DWF	phosphomethylpyrimidine kinase
TSIB_0464	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
TSIB_0465	ENOG4105C4U	4-methyl-5-beta-hydroxyethylthiazole kinase
TSIB_0466	ENOG4105ETU	transcriptional activator (TenA
TSIB_0468	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
TSIB_0470	ENOG4107TH8	cina domain protein
TSIB_0476	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
TSIB_0483	ENOG4105WMR	Protein CrcB homolog
TSIB_0484	ENOG4105KJJ	Uncharacterized ACR, COG1993
TSIB_0486	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
TSIB_0487	ENOG4105D64	Mechanosensitive ion channel
TSIB_0488	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
TSIB_0490	ENOG4105C22	threonyL-tRNA synthetase
TSIB_0497	ENOG4105D07	Signal peptide peptidase, SppA
TSIB_0499	ENOG4105F4G	Membrane
TSIB_0506	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
TSIB_0509	ENOG4105C3G	gtp-binding protein
TSIB_0514	ENOG4105UQX	Mate efflux family protein
TSIB_0515	ENOG4108K3F	N(2),N(2)-dimethylguanosine tRNA methyltransferase
TSIB_0520	ENOG4107Y70	Heat shock protein
TSIB_0522	ENOG4107R7Y	intracellular protease Pfpi family
TSIB_0523	ENOG410812S	Rna-binding protein
TSIB_0529	ENOG4105CD5	CoA-binding domain protein
TSIB_0530	ENOG4106K5Q	Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity)
TSIB_0534	ENOG4105CX6	glutaminyL-tRNA synthetase
TSIB_0535	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
TSIB_0538	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
TSIB_0539	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
TSIB_0542	ENOG4105CG9	aspartate racemase
TSIB_0548	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
TSIB_0549	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
TSIB_0567	ENOG4108J2R	molybdopterin oxidoreductase
TSIB_0570	ENOG4105CV8	reductase
TSIB_0575	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
TSIB_0579	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
TSIB_0580	ENOG4105CS2	ec 3.2.1.21
TSIB_0581	ENOG4105D2S	major facilitator superfamily
TSIB_0583	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
TSIB_0584	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
TSIB_0599	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
TSIB_0602	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
TSIB_0608	ENOG4105HDK	L-asparaginase
TSIB_0609	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
TSIB_0613	ENOG4107QMS	site-determining protein
TSIB_0614	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
TSIB_0615	ENOG4105CPQ	Dehydrogenase
TSIB_0617	ENOG4107TIA	phenylalanyl-tRNA synthetase (beta subunit)
TSIB_0618	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
TSIB_0619	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
TSIB_0620	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
TSIB_0623	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
TSIB_0625	ENOG4105U0R	haloacid dehalogenase-like hydrolase
TSIB_0628	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TSIB_0629	ENOG4105F1A	Pyruvate formate-lyase
TSIB_0630	ENOG4105CTU	Proline racemase
TSIB_0631	ENOG4105C6N	Formate acetyltransferase
TSIB_0632	ENOG4105C8J	)-transporter
TSIB_0633	ENOG4105CTU	Proline racemase
TSIB_0634	ENOG4105CIF	Ornithine Cyclodeaminase
TSIB_0640	ENOG4105DDR	sarcosine oxidase (Beta subunit)
TSIB_0649	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
TSIB_0650	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
TSIB_0659	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
TSIB_0660	ENOG4106IPI	cyclase, family
TSIB_0661	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
TSIB_0662	ENOG4107YZX	Universal stress protein
TSIB_0666	ENOG4105EEI	dihydropteroate synthase
TSIB_0669	ENOG4105FDK	ABC transporter
TSIB_0671	ENOG4108I5C	dEAD DEAH box helicase
TSIB_0677	ENOG4107QX8	SPFH domain, Band 7 family protein
TSIB_0678	ENOG4107QMS	site-determining protein
TSIB_0683	ENOG4108RCS	geranylgeranylglyceryl phosphate synthase
TSIB_0684	ENOG4108ME1	Peptidase M55 D-aminopeptidase
TSIB_0686	ENOG4105C1J	atp-dependent rna helicase
TSIB_0687	ENOG4105VYW	UPF0251 protein
TSIB_0690	ENOG4105D1F	ATP-binding protein
TSIB_0694	ENOG4105D7N	magnesium and cobalt transport protein CorA
TSIB_0696	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
TSIB_0697	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TSIB_0702	ENOG4105E8R	UPF0173 metal-dependent hydrolase
TSIB_0703	ENOG4105CHR	reductase
TSIB_0711	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
TSIB_0713	ENOG410825M	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
TSIB_0714	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
TSIB_0718	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
TSIB_0720	ENOG4105EM7	Selenocysteine-specific translation elongation factor
TSIB_0722	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
TSIB_0724	ENOG4105ECY	inositol monophosphatase
TSIB_0726	ENOG4107QW4	alcohol dehydrogenase
TSIB_0729	ENOG4105P4J	Allophanate hydrolase, subunit 1
TSIB_0730	ENOG4105E7W	lamb ycsf family protein
TSIB_0738	ENOG4105MRR	Transcriptional regulator (By similarity)
TSIB_0746	ENOG4107QJE	Chromosome Partitioning Protein
TSIB_0750	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
TSIB_0752	ENOG4108Z86	Glutamine amidotransferase
TSIB_0754	ENOG4108UKZ	OsmC family
TSIB_0755	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
TSIB_0759	ENOG41067S9	phage shock protein C, PspC
TSIB_0767	ENOG4105D4F	Synthesizes selenophosphate from selenide and ATP (By similarity)
TSIB_0768	ENOG4108HMR	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
TSIB_0770	ENOG4108JU3	Alkyl hydroperoxide reductase
TSIB_0771	ENOG4107R5Y	anaerobic glycerol-3-phosphate dehydrogenase, subunit A
TSIB_0774	ENOG4105CHM	Aminotransferase
TSIB_0792	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
TSIB_0793	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
TSIB_0799	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
TSIB_0800	ENOG4105CHU	acetyl-coa acetyltransferase
TSIB_0813	ENOG4108Y83	glucose-6-phosphate isomerase
TSIB_0814	ENOG4108Z4T	Peptidase M50
TSIB_0824	ENOG4108RYR	transcriptional regulator AsnC family
TSIB_0827	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
TSIB_0831	ENOG41083NF	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
TSIB_0835	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
TSIB_0839	ENOG4105SC1	monovalent cation H antiporter subunit E
TSIB_0840	ENOG41080TA	Multiple resistance and ph regulation protein f
TSIB_0841	ENOG4105KJM	monovalent cation h antiporter subunit g
TSIB_0846	ENOG4108JPZ	Monovalent cation H antiporter subunit D
TSIB_0850	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
TSIB_0851	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
TSIB_0861	ENOG4107WCI	zn-dependent hydrolase of the beta-lactamase fold-like protein
TSIB_0862	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
TSIB_0867	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
TSIB_0869	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
TSIB_0872	ENOG4108MYP	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
TSIB_0874	ENOG4105FEA	Spore maturation protein
TSIB_0875	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
TSIB_0879	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
TSIB_0880	ENOG4107S6Z	Na H antiporter
TSIB_0882	ENOG4106V2I	dimethylaminohydrolase
TSIB_0885	ENOG4107TRG	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity)
TSIB_0892	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
TSIB_0893	ENOG4105C7B	Threonine dehydratase
TSIB_0894	ENOG4105CHM	Aminotransferase
TSIB_0896	ENOG4105KPK	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
TSIB_0897	ENOG4105CY0	Metallo-Beta-Lactamase
TSIB_0900	ENOG4105E66	phosphoriboisomerase A
TSIB_0903	ENOG4105CH5	extracellular solute-binding protein, family 7
TSIB_0905	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
TSIB_0907	ENOG4108S8N	class II Aldolase
TSIB_0916	ENOG4105NBF	ammecr1 domain protein
TSIB_0918	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
TSIB_0919	ENOG4105CQ2	DNA polymerase
TSIB_0920	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
TSIB_0930	ENOG4105DVA	methyltransferase
TSIB_0933	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
TSIB_0935	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
TSIB_0936	ENOG4107RGW	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TSIB_0947	ENOG4107QJE	Chromosome Partitioning Protein
TSIB_0950	ENOG4107TIF	Phenazine biosynthesis protein, PhzF family
TSIB_0952	ENOG4105VZ9	UPF0235 protein
TSIB_0954	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
TSIB_0955	ENOG4108IIG	CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity)
TSIB_0958	ENOG4105E0R	Deoxyhypusine synthase
TSIB_0963	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
TSIB_0964	ENOG4105EPU	Molybdenum cofactor synthesis domain protein
TSIB_0968	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
TSIB_0972	ENOG4105D0M	Protease HtpX homolog
TSIB_0973	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
TSIB_0975	ENOG4105DZH	s-adenosylmethionine synthetase (EC 2.5.1.6)
TSIB_0977	ENOG4105Y7X	Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity)
TSIB_0981	ENOG4105C1A	potassium transporter peripheral membrane
TSIB_0983	ENOG4105CSC	Glucose uptake protein
TSIB_0984	ENOG4108XM1	transcriptional regulator AsnC family
TSIB_0985	ENOG4105CHM	Aminotransferase
TSIB_0987	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
TSIB_0991	ENOG4108JU3	Alkyl hydroperoxide reductase
TSIB_0992	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
TSIB_0994	ENOG4105C5S	asparaginyl-tRNA synthetase
TSIB_0997	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
TSIB_1003	ENOG4105D1F	ATP-binding protein
TSIB_1005	ENOG4108JPW	Aminotransferase
TSIB_1009	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
TSIB_1010	ENOG4108Y5D	Inherit from COG: cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
TSIB_1011	ENOG4105CTD	carboxy-peptidase
TSIB_1014	ENOG4108KN7	Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity)
TSIB_1015	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
TSIB_1016	ENOG4105C5I	Dehydrogenase
TSIB_1017	ENOG4108JQ1	Dehydrogenase
TSIB_1019	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
TSIB_1024	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
TSIB_1026	ENOG4105DC7	peptidase M24
TSIB_1027	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
TSIB_1041	ENOG4105C1J	atp-dependent rna helicase
TSIB_1043	ENOG4107QXV	Phosphate transporter
TSIB_1049	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
TSIB_1052	ENOG4105DEF	Extracellular solute-binding protein, family 5
TSIB_1053	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
TSIB_1054	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
TSIB_1056	ENOG4108JQ7	(ABC) transporter
TSIB_1058	ENOG4107SA6	carbon-phosphorus lyase complex accessory protein
TSIB_1059	ENOG4108TVJ	Nitroreductase
TSIB_1066	ENOG4108IYI	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
TSIB_1068	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
TSIB_1079	ENOG4105BZ1	(ABC) transporter
TSIB_1081	ENOG4105BZ1	(ABC) transporter
TSIB_1092	ENOG4105EAC	phosphoserine phosphatase
TSIB_1093	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
TSIB_1099	ENOG4105CD5	CoA-binding domain protein
TSIB_1100	ENOG4105DZA	Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity)
TSIB_1110	ENOG4105D82	Glutamate dehydrogenase
TSIB_1111	ENOG4105C8J	)-transporter
TSIB_1114	ENOG4108YZA	Nitrogen regulatory protein pii
TSIB_1115	ENOG4107RFW	hydrolase family 57
TSIB_1116	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
TSIB_1117	ENOG4108IYI	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
TSIB_1118	ENOG4107RDY	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
TSIB_1119	ENOG4105CFH	Aspartokinase
TSIB_1124	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
TSIB_1133	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
TSIB_1140	ENOG4105M7V	2'-5' rna ligase
TSIB_1142	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
TSIB_1148	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
TSIB_1150	ENOG4108JPW	Aminotransferase
TSIB_1151	ENOG4105C3M	thioredoxin reductase
TSIB_1155	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
TSIB_1163	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
TSIB_1168	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
TSIB_1178	ENOG4107S5Z	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity)
TSIB_1179	ENOG4105VFR	signal peptidase
TSIB_1182	ENOG4108IGT	Dipeptidase
TSIB_1184	ENOG4105C45	hydrogenase expression formation protein (HypE)
TSIB_1194	ENOG4108FN8	Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity)
TSIB_1195	ENOG4105DCI	Phosphohydrolase
TSIB_1198	ENOG4105C83	adenylosuccinate lyase
TSIB_1201	ENOG4105C2X	Arabinose 5-phosphate isomerase
TSIB_1202	ENOG4105F7N	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
TSIB_1208	ENOG4108D32	Methyltransferase
TSIB_1209	ENOG4108FN7	Aldo keto reductase
TSIB_1213	ENOG4105DVT	helicase
TSIB_1215	ENOG4105CN9	Peptidase m42 family protein
TSIB_1216	ENOG4105PW4	Sugar fermentation stimulation protein homolog
TSIB_1217	ENOG4107R8N	Glycosyl transferase, family 2
TSIB_1219	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
TSIB_1222	ENOG41074MP	UPF0103 Mediator of ErbB2-driven cell motility-containing protein
TSIB_1226	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
TSIB_1230	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
TSIB_1231	ENOG4106UJV	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
TSIB_1235	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
TSIB_1240	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
TSIB_1256	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
TSIB_1257	ENOG4108JJB	ABC transporter
TSIB_1264	ENOG4108ZPQ	MazG nucleotide pyrophosphohydrolase
TSIB_1270	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
TSIB_1273	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
TSIB_1274	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
TSIB_1276	ENOG4108UK2	deaminase
TSIB_1277	ENOG4105D0M	Protease HtpX homolog
TSIB_1279	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
TSIB_1280	ENOG4105C5I	Dehydrogenase
TSIB_1282	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
TSIB_1283	ENOG4107TDF	Formate hydrogenlyase subunit 4
TSIB_1284	ENOG4108HM5	NADH-ubiquinone oxidoreductase chain 49kDa
TSIB_1285	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
TSIB_1286	ENOG4105C47	NADH ubiquinone oxidoreductase 20 kda subunit
TSIB_1288	ENOG4108JPZ	Monovalent cation H antiporter subunit D
TSIB_1289	ENOG4108ZE9	Monovalent cation H antiporter subunit C
TSIB_1290	ENOG4105HC0	Na H antiporter
TSIB_1293	ENOG4105KJM	monovalent cation h antiporter subunit g
TSIB_1297	ENOG4107TDF	Formate hydrogenlyase subunit 4
TSIB_1298	ENOG4108HM5	NADH-ubiquinone oxidoreductase chain 49kDa
TSIB_1299	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TSIB_1300	ENOG4105C47	NADH ubiquinone oxidoreductase 20 kda subunit
TSIB_1302	ENOG4108JPZ	Monovalent cation H antiporter subunit D
TSIB_1303	ENOG4108ZE9	Monovalent cation H antiporter subunit C
TSIB_1307	ENOG4105KJM	monovalent cation h antiporter subunit g
TSIB_1308	ENOG41080TA	Multiple resistance and ph regulation protein f
TSIB_1309	ENOG4105SC1	monovalent cation H antiporter subunit E
TSIB_1310	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
TSIB_1312	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
TSIB_1314	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
TSIB_1317	ENOG4105G01	cobalamin (vitamin B12) biosynthesis CbiM protein
TSIB_1320	ENOG4108JJB	ABC transporter
TSIB_1321	ENOG4107R76	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
TSIB_1322	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
TSIB_1324	ENOG4105C8J	)-transporter
TSIB_1328	ENOG4105CHM	Aminotransferase
TSIB_1331	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
TSIB_1332	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
TSIB_1336	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
TSIB_1339	ENOG4105BZR	domain protein
TSIB_1348	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
TSIB_1349	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
TSIB_1350	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
TSIB_1352	ENOG4105F7N	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
TSIB_1359	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
TSIB_1361	ENOG4105C6T	cysteine synthase
TSIB_1362	ENOG4105CYW	agmatinase
TSIB_1365	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TSIB_1368	ENOG4105D7K	pfkb domain protein
TSIB_1371	ENOG4105CJ1	ABC, transporter
TSIB_1377	ENOG4105D1F	ATP-binding protein
TSIB_1378	ENOG4105DDK	oxidoreductase, beta subunit
TSIB_1379	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
TSIB_1381	ENOG4105DDK	oxidoreductase, beta subunit
TSIB_1382	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
TSIB_1386	ENOG4107QXV	Phosphate transporter
TSIB_1388	ENOG4105CJ1	ABC, transporter
TSIB_1389	ENOG4105VZ8	Transcriptional regulator
TSIB_1396	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
TSIB_1397	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
TSIB_1400	ENOG4108ZVT	methylmalonyl-coA epimerase
TSIB_1402	ENOG4105D5P	Methylmalonyl-coA mutase
TSIB_1403	ENOG4105DCG	PHP domain protein
TSIB_1404	ENOG4108Z03	MAF-like protein
TSIB_1405	ENOG4105CTP	PilT protein domain protein
TSIB_1407	ENOG4105CAQ	asparagine synthetase
TSIB_1410	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
TSIB_1419	ENOG4105CB1	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
TSIB_1424	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TSIB_1427	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
TSIB_1429	ENOG4108XM1	transcriptional regulator AsnC family
TSIB_1435	ENOG4105WRB	Hydrogenase assembly chaperone hypC hupF
TSIB_1436	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
TSIB_1441	ENOG4105CJ1	ABC, transporter
TSIB_1444	ENOG4105F8V	Hydrolase, tatD family
TSIB_1453	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
TSIB_1454	ENOG4108MUZ	hydrolase
TSIB_1455	ENOG4107QRT	dEAD DEAH box helicase
TSIB_1457	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
TSIB_1459	ENOG4105E0A	ABC, transporter
TSIB_1460	ENOG4105EHG	Permease protein
TSIB_1464	ENOG4105CDJ	oxidoreductase FAD NAD(P)-binding domain protein
TSIB_1465	ENOG4105BZ8	glutamate synthase
TSIB_1466	ENOG4105EJ5	oxidoreductase gamma subunit
TSIB_1467	ENOG4105DQU	oxidoreductase, subunit beta
TSIB_1468	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
TSIB_1470	ENOG4105DQU	oxidoreductase, subunit beta
TSIB_1471	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
TSIB_1475	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
TSIB_1476	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
TSIB_1492	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
TSIB_1494	ENOG4105ZHF	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
TSIB_1499	ENOG4105C45	hydrogenase expression formation protein (HypE)
TSIB_1503	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
TSIB_1504	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
TSIB_1505	ENOG4108JJB	ABC transporter
TSIB_1509	ENOG4105CN9	Peptidase m42 family protein
TSIB_1513	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
TSIB_1514	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
TSIB_1515	ENOG4105C5S	asparaginyl-tRNA synthetase
TSIB_1516	ENOG4107Y03	Nitroreductase
TSIB_1518	ENOG4107QIZ	NADH dehydrogenase
TSIB_1521	ENOG4107SHJ	sulfite reductase subunit b
TSIB_1528	ENOG4105CKX	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP
TSIB_1532	ENOG4105CDU	Replicative dna helicase
TSIB_1534	ENOG4105D8K	carboxyl transferase
TSIB_1536	ENOG4107QSA	Oxaloacetate decarboxylase
TSIB_1537	ENOG4105D9Q	decarboxylase (Beta subunit)
TSIB_1538	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
TSIB_1539	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
TSIB_1544	ENOG4105D9P	serine threonine protein kinase
TSIB_1545	ENOG4105C98	muts2 protein
TSIB_1546	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
TSIB_1547	ENOG4105K8R	UPF0145 protein
TSIB_1557	ENOG4105CIH	Imidazole acetol-phosphate transaminase
TSIB_1558	ENOG4108IPJ	Membrane
TSIB_1560	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
TSIB_1561	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
TSIB_1569	ENOG4105C5R	Aminotransferase
TSIB_1570	ENOG4108Z86	Glutamine amidotransferase
TSIB_1574	ENOG4106M28	alanine racemase domain protein
TSIB_1579	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
TSIB_1580	ENOG4105E3H	phosphoglycerate mutase
TSIB_1583	ENOG4107S6Z	Na H antiporter
TSIB_1584	ENOG41087GE	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
TSIB_1585	ENOG4105DBV	ornithine carbamoyltransferase
TSIB_1591	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
TSIB_1596	ENOG4105DT1	RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate
TSIB_1597	ENOG4107104	thymidine kinase
TSIB_1599	ENOG4107QK3	aspartate-semialdehyde dehydrogenase (EC 1.2.1.11
TSIB_1600	ENOG4108IYI	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
TSIB_1601	ENOG4107RDY	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
TSIB_1602	ENOG4105CFH	Aspartokinase
TSIB_1605	ENOG4105D1Z	hydroxypyruvate reductase
TSIB_1609	ENOG4105C5X	domain protein
TSIB_1610	ENOG4108F3G	Type I restriction-modification system, R subunit
TSIB_1619	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
TSIB_1623	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
TSIB_1626	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
TSIB_1628	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
TSIB_1630	ENOG4107SDT	Homocitrate synthase
TSIB_1633	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
TSIB_1634	ENOG4105EQN	UPF0261 protein
TSIB_1638	ENOG4105CPP	Dehydrogenase, E1 component
TSIB_1639	ENOG4107RUY	(E1 component), alpha subunit
TSIB_1641	ENOG4105C7S	Dehydrogenase
TSIB_1643	ENOG4106Z86	ATP-nad acox kinase
TSIB_1644	ENOG4107S5Z	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity)
TSIB_1646	ENOG4105CPP	Dehydrogenase, E1 component
TSIB_1647	ENOG4107RUY	(E1 component), alpha subunit
TSIB_1652	ENOG4108IYI	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
TSIB_1659	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
TSIB_1669	ENOG4105IPI	Membrane
TSIB_1670	ENOG4108RWI	nicotinamidase
TSIB_1673	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
TSIB_1674	ENOG4105VUN	Transcriptional regulator
TSIB_1676	ENOG4105HDK	L-asparaginase
TSIB_1678	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
TSIB_1681	ENOG4106J7S	Glycosyl transferase, family 2
TSIB_1687	ENOG4107NFR	Fructose-1,6-bisphosphatase
TSIB_1692	ENOG4105DIW	FeS assembly protein SUFB
TSIB_1697	ENOG4105PGM	cation diffusion facilitator family transporter
TSIB_1700	ENOG4105D6J	arsenicaL-resistance protein
TSIB_1705	ENOG4105EW9	transcriptional regulator AsnC family
TSIB_1709	ENOG4107UX3	phosphatidylethanolamine N-methyltransferase
TSIB_1716	ENOG4105EKT	)-iron permease
TSIB_1721	ENOG4105C3K	feS assembly ATPase SufC
TSIB_1722	ENOG41090A1	ferritin
TSIB_1724	ENOG4105D06	uba thif-type nad fad binding protein
TSIB_1740	ENOG4105CNW	domain protein
TSIB_1742	ENOG4105EJ7	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity)
TSIB_1744	ENOG4108IYC	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity)
TSIB_1755	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
TSIB_1756	ENOG4105C3U	ABC transporter
TSIB_1757	ENOG4108JQ7	(ABC) transporter
TSIB_1759	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
TSIB_1761	ENOG4105C5F	glutamine synthetase
TSIB_1768	ENOG4105EHU	Circadian clock protein KaiC
TSIB_1771	ENOG4105DR4	Methyltransferase
TSIB_1772	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
TSIB_1773	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
TSIB_1774	ENOG4105EPD	Oligopeptide transporter, Opt family
TSIB_1776	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
TSIB_1779	ENOG4108NGU	Transcriptional regulator
TSIB_1782	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
TSIB_1787	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
TSIB_1789	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
TSIB_1790	ENOG4105M56	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
TSIB_1791	ENOG4108JIP	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity)
TSIB_1792	ENOG4108JIQ	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity)
TSIB_1793	ENOG4105KXQ	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
TSIB_1795	ENOG4105K4G	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
TSIB_1799	ENOG4105C1A	potassium transporter peripheral membrane
TSIB_1800	ENOG4105C3D	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
TSIB_1801	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
TSIB_1802	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
TSIB_1804	ENOG4105EHU	Circadian clock protein KaiC
TSIB_1808	ENOG4107XF7	NGG1p interacting factor 3 protein, NIF3
TSIB_1812	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
TSIB_1822	ENOG4105EHU	Circadian clock protein KaiC
TSIB_1823	ENOG4105CKK	Glycosyl transferase, family 2
TSIB_1835	ENOG4105EWK	phytoene
TSIB_1839	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
TSIB_1840	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
TSIB_1851	ENOG4105EPH	radical SAM domain protein
TSIB_1852	ENOG4105TRT	Transcriptional regulator
TSIB_1855	ENOG4105D06	uba thif-type nad fad binding protein
TSIB_1856	ENOG4108ZAF	Molybdopterin
TSIB_1859	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
TSIB_1860	ENOG4108VVK	transcriptional Regulator, AsnC
TSIB_1863	ENOG4105S10	periplasmic binding protein
TSIB_1864	ENOG4105EHG	Permease protein
TSIB_1865	ENOG4105E0A	ABC, transporter
TSIB_1868	ENOG4105C26	Dehydrogenase
TSIB_1869	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
TSIB_1870	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
TSIB_1873	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TSIB_1876	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
TSIB_1877	ENOG4105E2Z	phosphate ABC transporter (Permease
TSIB_1878	ENOG4105C8U	phosphate abc transporter
TSIB_1880	ENOG4107QMV	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
TSIB_1887	ENOG4105E90	ABC transporter
TSIB_1888	ENOG4105E90	ABC transporter
TSIB_1889	ENOG4108IJ8	ABC transporter
TSIB_1890	ENOG4108HQR	Glycine betaine
TSIB_1894	ENOG4108YZ8	Superoxide reductase
TSIB_1895	ENOG4105VCQ	rubredoxin
TSIB_1896	ENOG4108RAC	Rubrerythrin
TSIB_1899	ENOG4105CNW	domain protein
TSIB_1900	ENOG4108IFH	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TSIB_1901	ENOG4105DQU	oxidoreductase, subunit beta
TSIB_1903	ENOG4105D3R	alkyl hydroperoxide reductase
TSIB_1905	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
TSIB_1906	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
TSIB_1907	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
TSIB_1908	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
TSIB_1909	ENOG4108IZQ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
TSIB_1910	ENOG4108JPZ	Monovalent cation H antiporter subunit D
TSIB_1911	ENOG4108JPZ	Monovalent cation H antiporter subunit D
TSIB_1913	ENOG4105D65	subunit l
TSIB_1915	ENOG4105KJM	monovalent cation h antiporter subunit g
TSIB_1916	ENOG410684G	monovalent cation H antiporter subunit F
TSIB_1917	ENOG4105SC1	monovalent cation H antiporter subunit E
TSIB_1919	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
TSIB_1920	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
TSIB_1921	ENOG4108IJ1	Dehydrogenase
TSIB_1925	ENOG4105C75	arginyL-tRNA synthetase
TSIB_1926	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
TSIB_1949	ENOG4107Y7Q	pfkb domain protein
TSIB_1954	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
TSIB_1961	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
TSIB_1962	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
TSIB_1963	ENOG4105ERH	Fumarylacetoacetate hydrolase
TSIB_1965	ENOG4105CD5	CoA-binding domain protein
TSIB_1966	ENOG41082SX	arsR family transcriptional regulator
TSIB_1969	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
TSIB_1979	ENOG4105D1H	recombination factor protein RarA
TSIB_1980	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
TSIB_1981	ENOG4105CB1	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
TSIB_1984	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
TSIB_1991	ENOG4105CYV	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity)
TSIB_1993	ENOG4107PBV	potassium channel
TSIB_1998	ENOG4105CHR	reductase
TSIB_1999	ENOG4108V1U	phospholipid-binding protein
TSIB_2007	ENOG4108JPW	Aminotransferase
TSIB_2021	ENOG4107RA4	Glycosyl transferase (Group 1
TSIB_2023	ENOG4105CAQ	asparagine synthetase
TSIB_2024	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
TSIB_2026	ENOG4107R8N	Glycosyl transferase, family 2
TSIB_2027	ENOG4105J5G	Transferase hexapeptide repeat containing protein
TSIB_2035	ENOG4105E4P	ATPase (AAA
TSIB_2037	ENOG4107RIQ	Sulfate adenylate transferase
TSIB_2044	ENOG4107V9E	glucose-1-phosphate thymidylyltransferase
TSIB_2047	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
TSIB_2050	ENOG4105K64	Glycosyl transferase, family 2
TSIB_2059	ENOG4107RGC	Glycosyl transferase, family 2
TSIB_2061	ENOG4107RA4	Glycosyl transferase (Group 1