locus-tag	class	description
TSIB_0005	COG1215	transferase activity, transferring glycosyl groups
TSIB_0006	COG0463	Glycosyl transferase, family 2
TSIB_0010	COG0714	Associated with various cellular activities
TSIB_0023	COG0647	UMP catabolic process
TSIB_0026	COG0557	exoribonuclease II activity
TSIB_0031	COG2264	protein methyltransferase activity
TSIB_0035	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TSIB_0044	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TSIB_0044	COG0519	Catalyzes the synthesis of GMP from XMP
TSIB_0047	COG0519	Catalyzes the synthesis of GMP from XMP
TSIB_0047	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TSIB_0048	COG0516	GMP reductase activity
TSIB_0048	COG0517	IMP dehydrogenase activity
TSIB_0054	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TSIB_0055	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TSIB_0056	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TSIB_0057	COG0047	phosphoribosylformylglycinamidine synthase activity
TSIB_0060	COG0151	Belongs to the GarS family
TSIB_0063	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
TSIB_0064	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TSIB_0065	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TSIB_0066	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TSIB_0067	COG3383	formate dehydrogenase (NAD+) activity
TSIB_0072	COG0668	transmembrane transport
TSIB_0073	COG2264	protein methyltransferase activity
TSIB_0079	COG0124	histidyl-tRNA synthetase
TSIB_0085	COG1346	cytolysis
TSIB_0086	COG1380	Effector of murein hydrolase LrgA
TSIB_0087	COG0251	oxidation-reduction process
TSIB_0089	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TSIB_0091	COG1215	transferase activity, transferring glycosyl groups
TSIB_0093	COG0343	queuine tRNA-ribosyltransferase activity
TSIB_0096	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TSIB_0098	COG0456	acetyltransferase
TSIB_0100	COG0156	8-amino-7-oxononanoate synthase activity
TSIB_0101	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TSIB_0105	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TSIB_0107	COG3557	Belongs to the UPF0374 family
TSIB_0108	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TSIB_0109	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TSIB_0113	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TSIB_0122	COG2252	PERMEase
TSIB_0123	COG0281	malic enzyme
TSIB_0127	COG2151	metal-sulfur cluster biosynthetic enzyme
TSIB_0128	COG1141	Ferredoxin
TSIB_0129	COG1141	Ferredoxin
TSIB_0133	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TSIB_0133	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TSIB_0136	COG0730	response to heat
TSIB_0137	COG1363	Peptidase, m42
TSIB_0141	COG1131	(ABC) transporter
TSIB_0142	COG1131	(ABC) transporter
TSIB_0148	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TSIB_0150	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TSIB_0157	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TSIB_0160	COG2403	cyclic 2,3-diphosphoglycerate synthetase activity
TSIB_0161	COG0725	ABC transporter, periplasmic molybdate-binding protein
TSIB_0162	COG4149	molybdate abc transporter
TSIB_0163	COG3842	ATPase activity
TSIB_0165	COG1201	RNA secondary structure unwinding
TSIB_0169	COG1505	serine-type exopeptidase activity
TSIB_0173	COG1047	Peptidyl-prolyl cis-trans
TSIB_0174	COG0215	cysteine-tRNA ligase activity
TSIB_0175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TSIB_0175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TSIB_0182	COG1744	ABC transporter substrate-binding protein PnrA-like
TSIB_0186	COG2226	methyltransferase
TSIB_0193	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TSIB_0198	COG1992	Thiamine-phosphate synthase
TSIB_0198	COG0351	phosphomethylpyrimidine kinase
TSIB_0200	COG0432	Pfam Uncharacterised protein family UPF0047
TSIB_0201	COG1234	tRNA 3'-trailer cleavage
TSIB_0206	COG1042	CoA-binding domain protein
TSIB_0206	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TSIB_0206	COG0045	succinate-CoA ligase (ADP-forming) activity
TSIB_0210	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TSIB_0215	COG0126	phosphoglycerate kinase activity
TSIB_0221	COG1178	ABC-type Fe3 transport system permease component
TSIB_0225	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TSIB_0229	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
TSIB_0229	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
TSIB_0230	COG1830	Aldolase
TSIB_0232	COG1966	Carbon starvation protein
TSIB_0238	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TSIB_0238	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TSIB_0246	COG0010	Belongs to the arginase family
TSIB_0248	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TSIB_0250	COG3769	mannosylglycerate metabolic process
TSIB_0253	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TSIB_0253	COG1793	dna ligase
TSIB_0254	COG0509	glycine decarboxylation via glycine cleavage system
TSIB_0263	COG0446	pyridine nucleotide-disulphide oxidoreductase
TSIB_0267	COG1404	Belongs to the peptidase S8 family
TSIB_0268	COG1473	amidohydrolase
TSIB_0271	COG0574	Belongs to the PEP-utilizing enzyme family
TSIB_0271	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TSIB_0272	COG0675	Transposase, IS605 OrfB family
TSIB_0273	COG0534	Mate efflux family protein
TSIB_0276	COG1446	asparaginase
TSIB_0277	COG2814	Major facilitator Superfamily
TSIB_0278	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TSIB_0281	COG2271	Major facilitator Superfamily
TSIB_0284	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
TSIB_0288	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TSIB_0290	COG0089	rRNA binding
TSIB_0291	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TSIB_0292	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TSIB_0293	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TSIB_0295	COG0255	Belongs to the universal ribosomal protein uL29 family
TSIB_0298	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TSIB_0299	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TSIB_0300	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TSIB_0302	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TSIB_0304	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TSIB_0305	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TSIB_0308	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TSIB_0309	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TSIB_0311	COG0200	Binds to the 23S rRNA
TSIB_0316	COG1102	Psort location Cytoplasmic, score
TSIB_0318	COG1028	Short-chain dehydrogenase reductase Sdr
TSIB_0319	COG4221	oxidoreductase activity
TSIB_0324	COG2723	6-phospho-beta-galactosidase activity
TSIB_0330	COG0601	transmembrane transport
TSIB_0331	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSIB_0332	COG0444	Belongs to the ABC transporter superfamily
TSIB_0334	COG2723	6-phospho-beta-galactosidase activity
TSIB_0337	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TSIB_0338	COG2813	Specifically methylates the guanine in position
TSIB_0339	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TSIB_0340	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TSIB_0344	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TSIB_0345	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TSIB_0348	COG0148	phosphopyruvate hydratase activity
TSIB_0349	COG0052	Belongs to the universal ribosomal protein uS2 family
TSIB_0351	COG0301	tRNA thio-modification
TSIB_0353	COG0301	tRNA thio-modification
TSIB_0355	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TSIB_0357	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TSIB_0358	COG1653	transport
TSIB_0360	COG0395	ABC-type sugar transport system, permease component
TSIB_0361	COG0438	transferase activity, transferring glycosyl groups
TSIB_0363	COG3842	ATPase activity
TSIB_0367	COG4208	sulfate ABC transporter
TSIB_0368	COG3842	ATPase activity
TSIB_0369	COG4143	(ABC) transporter
TSIB_0370	COG0434	BtpA family
TSIB_0379	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TSIB_0382	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TSIB_0383	COG0081	regulation of translation
TSIB_0386	COG0717	Belongs to the dCTP deaminase family
TSIB_0388	COG0085	RNA polymerase activity
TSIB_0389	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TSIB_0390	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TSIB_0394	COG0049	tRNA binding
TSIB_0397	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TSIB_0400	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TSIB_0401	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
TSIB_0409	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TSIB_0410	COG2095	MarC family integral membrane protein
TSIB_0413	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TSIB_0417	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TSIB_0427	COG0010	Belongs to the arginase family
TSIB_0428	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
TSIB_0433	COG1418	mRNA catabolic process
TSIB_0435	COG0017	Asparaginyl-tRNA synthetase
TSIB_0438	COG0585	pseudouridine synthase activity
TSIB_0440	COG0284	orotidine-5'-phosphate decarboxylase activity
TSIB_0441	COG0167	dihydroorotate dehydrogenase activity
TSIB_0443	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TSIB_0444	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
TSIB_0445	COG0540	Belongs to the ATCase OTCase family
TSIB_0446	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TSIB_0448	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TSIB_0449	COG1522	sequence-specific DNA binding
TSIB_0450	COG0475	glutathione-regulated potassium exporter activity
TSIB_0451	COG0475	glutathione-regulated potassium exporter activity
TSIB_0454	COG0037	tRNA processing
TSIB_0455	COG1449	Belongs to the glycosyl hydrolase 57 family
TSIB_0459	COG0475	glutathione-regulated potassium exporter activity
TSIB_0462	COG0351	phosphomethylpyrimidine kinase
TSIB_0464	COG0352	thiamine-phosphate diphosphorylase activity
TSIB_0465	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
TSIB_0466	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
TSIB_0468	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TSIB_0470	COG1058	Belongs to the CinA family
TSIB_0470	COG1546	Belongs to the CinA family
TSIB_0471	COG0469	pyruvate kinase activity
TSIB_0476	COG2414	aldehyde ferredoxin oxidoreductase
TSIB_0483	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TSIB_0484	COG1993	acr, cog1993
TSIB_0487	COG0668	transmembrane transport
TSIB_0488	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TSIB_0490	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TSIB_0497	COG0616	signal peptide processing
TSIB_0499	COG0628	permease
TSIB_0504	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TSIB_0506	COG0163	prenyltransferase activity
TSIB_0509	COG0012	GTP binding
TSIB_0514	COG0534	Mate efflux family protein
TSIB_0515	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
TSIB_0520	COG0071	Belongs to the small heat shock protein (HSP20) family
TSIB_0522	COG0693	protein deglycase activity
TSIB_0523	COG1534	Rna-binding protein
TSIB_0529	COG0045	succinate-CoA ligase (ADP-forming) activity
TSIB_0529	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TSIB_0529	COG1042	CoA-binding domain protein
TSIB_0530	COG1110	DNA topoisomerase II activity
TSIB_0534	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TSIB_0535	COG0105	UTP biosynthetic process
TSIB_0538	COG0312	modulator of DNA gyrase
TSIB_0539	COG0312	modulator of DNA gyrase
TSIB_0542	COG1794	racemase activity, acting on amino acids and derivatives
TSIB_0548	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TSIB_0549	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TSIB_0567	COG0243	molybdopterin cofactor binding
TSIB_0570	COG0656	L-ascorbic acid biosynthetic process
TSIB_0575	COG1185	polyribonucleotide nucleotidyltransferase activity
TSIB_0579	COG1085	galactose-1-phosphate uridylyltransferase
TSIB_0583	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TSIB_0584	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TSIB_0599	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TSIB_0602	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TSIB_0608	COG0252	asparaginase activity
TSIB_0609	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TSIB_0613	COG2894	cell division
TSIB_0614	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TSIB_0615	COG1063	alcohol dehydrogenase
TSIB_0617	COG0072	phenylalanine-tRNA ligase activity
TSIB_0618	COG0101	tRNA pseudouridine synthase activity
TSIB_0619	COG0556	nucleotide-excision repair
TSIB_0621	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TSIB_0623	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TSIB_0628	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TSIB_0632	COG0733	neurotransmitter:sodium symporter activity
TSIB_0640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TSIB_0649	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TSIB_0650	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TSIB_0659	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TSIB_0660	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
TSIB_0661	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TSIB_0662	COG0589	response to stress
TSIB_0666	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TSIB_0669	COG1121	(ABC) transporter
TSIB_0671	COG1111	helicase
TSIB_0671	COG1205	dead DEAH box helicase
TSIB_0674	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TSIB_0677	COG0330	HflC and HflK could
TSIB_0678	COG2894	cell division
TSIB_0683	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
TSIB_0684	COG2362	D-Aminopeptidase
TSIB_0686	COG0513	Belongs to the DEAD box helicase family
TSIB_0687	COG1342	Belongs to the UPF0251 family
TSIB_0690	COG0489	protein tyrosine kinase activity
TSIB_0691	COG0489	protein tyrosine kinase activity
TSIB_0694	COG0598	Magnesium transport protein CorA
TSIB_0696	COG2226	methyltransferase
TSIB_0697	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TSIB_0697	COG0731	radical SAM domain protein
TSIB_0702	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TSIB_0711	COG0109	protoheme IX farnesyltransferase activity
TSIB_0713	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TSIB_0714	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TSIB_0718	COG0477	Major facilitator Superfamily
TSIB_0722	COG1196	nuclear chromosome segregation
TSIB_0724	COG0483	inositol monophosphate 1-phosphatase activity
TSIB_0726	COG1979	alcohol dehydrogenase
TSIB_0728	COG1984	allophanate hydrolase subunit 2
TSIB_0729	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TSIB_0730	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TSIB_0738	COG0864	Transcriptional regulator
TSIB_0746	COG1192	Involved in chromosome partitioning
TSIB_0750	COG0720	synthase
TSIB_0752	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TSIB_0754	COG1765	OsmC-like protein
TSIB_0755	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TSIB_0759	COG1983	PspC domain protein
TSIB_0767	COG0709	Synthesizes selenophosphate from selenide and ATP
TSIB_0768	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TSIB_0771	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TSIB_0773	COG0277	FAD linked oxidase domain protein
TSIB_0774	COG0436	Aminotransferase
TSIB_0775	COG2192	nodulation
TSIB_0792	COG0148	phosphopyruvate hydratase activity
TSIB_0793	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TSIB_0799	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TSIB_0800	COG0183	Belongs to the thiolase family
TSIB_0813	COG2140	Oxalate decarboxylase
TSIB_0814	COG1994	Peptidase M50
TSIB_0824	COG1522	sequence-specific DNA binding
TSIB_0827	COG1234	tRNA 3'-trailer cleavage
TSIB_0831	COG0746	molybdenum cofactor guanylyltransferase activity
TSIB_0835	COG0563	adenylate kinase activity
TSIB_0839	COG1863	multisubunit Na H antiporter MnhE subunit
TSIB_0840	COG2212	antiporter activity
TSIB_0846	COG0651	ATP synthesis coupled electron transport
TSIB_0850	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TSIB_0851	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TSIB_0861	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TSIB_0862	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TSIB_0869	COG1444	tRNA N-acetyltransferase activity
TSIB_0872	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
TSIB_0874	COG1388	LysM domain
TSIB_0874	COG4641	Protein conserved in bacteria
TSIB_0875	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TSIB_0879	COG1573	uracil-dna glycosylase
TSIB_0880	COG1757	Na H antiporter
TSIB_0882	COG1834	amidinotransferase
TSIB_0885	COG1793	dna ligase
TSIB_0894	COG0436	Aminotransferase
TSIB_0896	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TSIB_0897	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TSIB_0900	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TSIB_0903	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TSIB_0905	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TSIB_0907	COG0235	Class ii aldolase
TSIB_0911	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TSIB_0915	COG0011	TIGRFAM Protein of
TSIB_0916	COG2078	PFAM AMMECR1 domain protein
TSIB_0918	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TSIB_0918	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TSIB_0919	COG0417	DNA replication proofreading
TSIB_0920	COG0563	adenylate kinase activity
TSIB_0924	COG0444	Belongs to the ABC transporter superfamily
TSIB_0930	COG2226	methyltransferase
TSIB_0933	COG0312	modulator of DNA gyrase
TSIB_0935	COG0312	modulator of DNA gyrase
TSIB_0936	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TSIB_0947	COG1192	Involved in chromosome partitioning
TSIB_0950	COG0384	phenazine biosynthesis protein PhzF
TSIB_0952	COG1872	DUF167
TSIB_0954	COG0423	glycine-tRNA ligase activity
TSIB_0958	COG1899	peptidyl-lysine modification to peptidyl-hypusine
TSIB_0963	COG0303	'Molybdopterin
TSIB_0968	COG0525	valine-tRNA ligase activity
TSIB_0972	COG0501	Belongs to the peptidase M48B family
TSIB_0973	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TSIB_0975	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
TSIB_0977	COG1515	deoxyribonuclease V activity
TSIB_0981	COG0569	domain protein
TSIB_0984	COG1522	sequence-specific DNA binding
TSIB_0985	COG0436	Aminotransferase
TSIB_0987	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TSIB_0994	COG0017	Asparaginyl-tRNA synthetase
TSIB_0997	COG0494	nUDIX hydrolase
TSIB_1003	COG0489	protein tyrosine kinase activity
TSIB_1005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TSIB_1009	COG2414	aldehyde ferredoxin oxidoreductase
TSIB_1010	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TSIB_1010	COG1213	nucleotidyl transferase
TSIB_1011	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TSIB_1014	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TSIB_1015	COG0442	prolyl-tRNA aminoacylation
TSIB_1016	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TSIB_1017	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TSIB_1019	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
TSIB_1024	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TSIB_1026	COG0006	proline dipeptidase activity
TSIB_1027	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TSIB_1041	COG0513	Belongs to the DEAD box helicase family
TSIB_1043	COG0306	phosphate transporter
TSIB_1049	COG4946	Tricorn protease homolog
TSIB_1049	COG1506	peptidase
TSIB_1049	COG0823	Involved in the tonB-independent uptake of proteins
TSIB_1052	COG0747	negative chemotaxis
TSIB_1053	COG0601	transmembrane transport
TSIB_1054	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSIB_1055	COG0444	Belongs to the ABC transporter superfamily
TSIB_1056	COG4608	Belongs to the ABC transporter superfamily
TSIB_1058	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TSIB_1059	COG0778	Nitroreductase
TSIB_1066	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TSIB_1068	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TSIB_1068	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TSIB_1079	COG1132	(ABC) transporter
TSIB_1081	COG1132	(ABC) transporter
TSIB_1082	COG1051	belongs to the nudix hydrolase family
TSIB_1082	COG1056	cytidyltransferase-related domain
TSIB_1092	COG0560	Phosphoserine phosphatase
TSIB_1093	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TSIB_1100	COG1469	GTP cyclohydrolase I activity
TSIB_1110	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TSIB_1111	COG0733	neurotransmitter:sodium symporter activity
TSIB_1114	COG0347	Belongs to the P(II) protein family
TSIB_1115	COG1543	Belongs to the glycosyl hydrolase 57 family
TSIB_1116	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TSIB_1117	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TSIB_1118	COG0083	homoserine kinase activity
TSIB_1119	COG0527	aspartate kinase activity
TSIB_1133	COG2414	aldehyde ferredoxin oxidoreductase
TSIB_1140	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TSIB_1142	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TSIB_1144	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TSIB_1148	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TSIB_1150	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TSIB_1151	COG0492	ferredoxin-NADP+ reductase activity
TSIB_1155	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TSIB_1163	COG1254	Belongs to the acylphosphatase family
TSIB_1168	COG0037	tRNA processing
TSIB_1178	COG0095	Lipoate-protein ligase
TSIB_1179	COG0681	Belongs to the peptidase S26 family
TSIB_1184	COG0309	Hydrogenase expression formation protein (HypE)
TSIB_1194	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TSIB_1195	COG1078	dGTPase activity
TSIB_1198	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TSIB_1201	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TSIB_1201	COG0517	IMP dehydrogenase activity
TSIB_1202	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TSIB_1208	COG2226	methyltransferase
TSIB_1209	COG0667	Aldo Keto reductase
TSIB_1213	COG1199	ATP-dependent helicase activity
TSIB_1216	COG1489	DNA binding
TSIB_1217	COG1215	transferase activity, transferring glycosyl groups
TSIB_1222	COG1355	regulation of microtubule-based process
TSIB_1230	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TSIB_1235	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TSIB_1239	COG2233	PERMEase
TSIB_1240	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TSIB_1241	COG1522	sequence-specific DNA binding
TSIB_1256	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TSIB_1257	COG1122	ATPase activity
TSIB_1264	COG1694	Mazg nucleotide pyrophosphohydrolase
TSIB_1265	COG1522	sequence-specific DNA binding
TSIB_1273	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TSIB_1276	COG2131	deaminase
TSIB_1277	COG0501	Belongs to the peptidase M48B family
TSIB_1279	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TSIB_1280	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TSIB_1282	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TSIB_1283	COG0650	Formate hydrogenlyase subunit 4
TSIB_1285	COG0649	NAD binding
TSIB_1285	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TSIB_1286	COG3260	NADH ubiquinone oxidoreductase 20
TSIB_1288	COG0651	ATP synthesis coupled electron transport
TSIB_1289	COG1006	Multisubunit Na H antiporter MnhC subunit
TSIB_1290	COG2111	Na H antiporter
TSIB_1293	COG1320	monovalent cation:proton antiporter activity
TSIB_1294	COG2212	antiporter activity
TSIB_1297	COG0650	Formate hydrogenlyase subunit 4
TSIB_1299	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TSIB_1300	COG3260	NADH ubiquinone oxidoreductase 20
TSIB_1302	COG0651	ATP synthesis coupled electron transport
TSIB_1303	COG1006	Multisubunit Na H antiporter MnhC subunit
TSIB_1307	COG1320	monovalent cation:proton antiporter activity
TSIB_1308	COG2212	antiporter activity
TSIB_1309	COG1863	multisubunit Na H antiporter MnhE subunit
TSIB_1310	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TSIB_1312	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TSIB_1314	COG0516	GMP reductase activity
TSIB_1314	COG0517	IMP dehydrogenase activity
TSIB_1317	COG0310	cobalt ion transport
TSIB_1320	COG1122	ATPase activity
TSIB_1321	COG0058	SHG alpha-glucan phosphorylase activity
TSIB_1324	COG0733	neurotransmitter:sodium symporter activity
TSIB_1327	COG2119	membrane
TSIB_1331	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TSIB_1332	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TSIB_1332	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TSIB_1336	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TSIB_1336	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TSIB_1339	COG0359	binds to the 23S rRNA
TSIB_1339	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
TSIB_1348	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TSIB_1349	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TSIB_1350	COG1185	polyribonucleotide nucleotidyltransferase activity
TSIB_1352	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TSIB_1359	COG0504	CTP synthase activity
TSIB_1361	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TSIB_1365	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TSIB_1368	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TSIB_1371	COG1131	(ABC) transporter
TSIB_1377	COG0489	protein tyrosine kinase activity
TSIB_1378	COG1013	pyruvate-flavodoxin oxidoreductase activity
TSIB_1379	COG0674	pyruvate-flavodoxin oxidoreductase activity
TSIB_1381	COG1013	pyruvate-flavodoxin oxidoreductase activity
TSIB_1382	COG0674	pyruvate-flavodoxin oxidoreductase activity
TSIB_1388	COG1131	(ABC) transporter
TSIB_1389	COG1476	TRANSCRIPTIONal
TSIB_1396	COG0303	'Molybdopterin
TSIB_1397	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TSIB_1400	COG0346	lactoylglutathione lyase activity
TSIB_1402	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TSIB_1402	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TSIB_1403	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TSIB_1404	COG0424	maF-like protein
TSIB_1405	COG4956	integral membrane protein (PIN domain superfamily)
TSIB_1406	COG2894	cell division
TSIB_1407	COG0367	asparagine synthase
TSIB_1410	COG0009	L-threonylcarbamoyladenylate synthase
TSIB_1419	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TSIB_1424	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TSIB_1427	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TSIB_1429	COG1522	sequence-specific DNA binding
TSIB_1434	COG0409	Hydrogenase expression formation protein
TSIB_1435	COG0298	carbon dioxide binding
TSIB_1436	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TSIB_1441	COG1131	(ABC) transporter
TSIB_1444	COG0084	hydrolase, TatD family'
TSIB_1453	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TSIB_1454	COG2267	carboxylic ester hydrolase activity
TSIB_1455	COG1201	RNA secondary structure unwinding
TSIB_1459	COG1120	ATPase activity
TSIB_1460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TSIB_1461	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TSIB_1464	COG0543	2 iron, 2 sulfur cluster binding
TSIB_1465	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TSIB_1465	COG0493	'glutamate synthase
TSIB_1466	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TSIB_1467	COG1013	pyruvate-flavodoxin oxidoreductase activity
TSIB_1468	COG0674	pyruvate-flavodoxin oxidoreductase activity
TSIB_1468	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TSIB_1470	COG1013	pyruvate-flavodoxin oxidoreductase activity
TSIB_1471	COG0674	pyruvate-flavodoxin oxidoreductase activity
TSIB_1471	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TSIB_1475	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TSIB_1476	COG0516	GMP reductase activity
TSIB_1492	COG1518	maintenance of DNA repeat elements
TSIB_1494	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TSIB_1495	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
TSIB_1503	COG0024	Methionine aminopeptidase
TSIB_1504	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TSIB_1505	COG1122	ATPase activity
TSIB_1513	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TSIB_1514	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TSIB_1515	COG0017	Asparaginyl-tRNA synthetase
TSIB_1516	COG0778	Nitroreductase
TSIB_1528	COG0430	RNA-3'-phosphate cyclase activity
TSIB_1532	COG0305	Participates in initiation and elongation during chromosome replication
TSIB_1532	COG1372	Participates in initiation and elongation during chromosome replication
TSIB_1534	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TSIB_1536	COG5016	pyruvate
TSIB_1536	COG0511	ligase activity, forming carbon-carbon bonds
TSIB_1537	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
TSIB_1539	COG1739	Uncharacterized protein family UPF0029
TSIB_1544	COG2815	serine threonine protein kinase
TSIB_1544	COG0515	serine threonine protein kinase
TSIB_1545	COG1193	negative regulation of DNA recombination
TSIB_1546	COG0315	cyclic pyranopterin monophosphate synthase activity
TSIB_1547	COG0393	Putative heavy-metal-binding
TSIB_1558	COG0697	spore germination
TSIB_1560	COG0051	transcription antitermination factor activity, RNA binding
TSIB_1561	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TSIB_1569	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TSIB_1570	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TSIB_1573	COG1288	antiporter activity
TSIB_1574	COG3457	Alanine racemase
TSIB_1579	COG1573	uracil-dna glycosylase
TSIB_1580	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TSIB_1583	COG1757	Na H antiporter
TSIB_1584	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TSIB_1585	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TSIB_1591	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TSIB_1596	COG1850	ribulose-bisphosphate carboxylase activity
TSIB_1597	COG1435	thymidine kinase activity
TSIB_1600	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TSIB_1601	COG0083	homoserine kinase activity
TSIB_1602	COG0527	aspartate kinase activity
TSIB_1605	COG2379	hydroxypyruvate reductase
TSIB_1609	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TSIB_1619	COG2414	aldehyde ferredoxin oxidoreductase
TSIB_1623	COG0574	Belongs to the PEP-utilizing enzyme family
TSIB_1623	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TSIB_1626	COG2414	aldehyde ferredoxin oxidoreductase
TSIB_1628	COG2414	aldehyde ferredoxin oxidoreductase
TSIB_1630	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TSIB_1633	COG0039	L-malate dehydrogenase activity
TSIB_1634	COG5441	Belongs to the UPF0261 family
TSIB_1635	COG0574	Belongs to the PEP-utilizing enzyme family
TSIB_1635	COG3848	Pyruvate phosphate dikinase
TSIB_1638	COG0022	dehydrogenase e1 component
TSIB_1639	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TSIB_1641	COG0508	dehydrogenase complex catalyzes the overall conversion of
TSIB_1643	COG3199	ATP-NAD kinase
TSIB_1644	COG0095	Lipoate-protein ligase
TSIB_1646	COG0022	dehydrogenase e1 component
TSIB_1647	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TSIB_1652	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TSIB_1659	COG1160	GTP binding
TSIB_1669	COG0628	permease
TSIB_1670	COG1335	isochorismatase
TSIB_1673	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TSIB_1673	COG2050	protein possibly involved in aromatic compounds catabolism
TSIB_1674	COG1695	Transcriptional regulator
TSIB_1676	COG0252	asparaginase activity
TSIB_1678	COG1185	polyribonucleotide nucleotidyltransferase activity
TSIB_1681	COG0463	Glycosyl transferase, family 2
TSIB_1682	COG0673	inositol 2-dehydrogenase activity
TSIB_1687	COG1980	fructose-bisphosphate aldolase activity
TSIB_1692	COG0719	Fe-S assembly protein
TSIB_1697	COG1230	cation diffusion facilitator family transporter
TSIB_1699	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TSIB_1700	COG0798	PFAM Bile acid sodium symporter
TSIB_1716	COG0672	)-iron permease
TSIB_1717	COG0450	alkyl hydroperoxide reductase
TSIB_1721	COG0396	ATPase activity
TSIB_1722	COG1528	Iron-storage protein
TSIB_1724	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TSIB_1740	COG0426	domain, Protein
TSIB_1742	COG1151	hydroxylamine reductase activity
TSIB_1754	COG0601	transmembrane transport
TSIB_1755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSIB_1756	COG0444	Belongs to the ABC transporter superfamily
TSIB_1757	COG4608	Belongs to the ABC transporter superfamily
TSIB_1759	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TSIB_1761	COG0174	glutamine synthetase
TSIB_1765	COG0697	spore germination
TSIB_1768	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TSIB_1771	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TSIB_1773	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TSIB_1774	COG1297	OPT oligopeptide transporter protein
TSIB_1776	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TSIB_1779	COG1378	Sugar-specific transcriptional regulator TrmB
TSIB_1782	COG0442	prolyl-tRNA aminoacylation
TSIB_1787	COG0482	sulfurtransferase activity
TSIB_1789	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TSIB_1791	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TSIB_1792	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TSIB_1793	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
TSIB_1795	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TSIB_1797	COG1269	ATP hydrolysis coupled proton transport
TSIB_1799	COG0569	domain protein
TSIB_1800	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TSIB_1804	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TSIB_1808	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TSIB_1822	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TSIB_1823	COG0463	Glycosyl transferase, family 2
TSIB_1839	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TSIB_1840	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TSIB_1842	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TSIB_1842	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TSIB_1851	COG1032	radical SAM domain protein
TSIB_1852	COG1510	regulation of RNA biosynthetic process
TSIB_1855	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TSIB_1856	COG0314	molybdopterin synthase activity
TSIB_1859	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TSIB_1860	COG1522	sequence-specific DNA binding
TSIB_1864	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TSIB_1865	COG1120	ATPase activity
TSIB_1868	COG1012	belongs to the aldehyde dehydrogenase family
TSIB_1869	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TSIB_1870	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TSIB_1873	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TSIB_1876	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TSIB_1887	COG1174	glycine betaine transport
TSIB_1888	COG1174	glycine betaine transport
TSIB_1889	COG1125	glycine betaine transport
TSIB_1889	COG0517	IMP dehydrogenase activity
TSIB_1890	COG1732	Glycine betaine
TSIB_1894	COG2033	superoxide reductase activity
TSIB_1895	COG1773	rubredoxin
TSIB_1896	COG1592	Rubrerythrin
TSIB_1899	COG0426	domain, Protein
TSIB_1900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TSIB_1901	COG1013	pyruvate-flavodoxin oxidoreductase activity
TSIB_1903	COG0450	alkyl hydroperoxide reductase
TSIB_1906	COG0649	NAD binding
TSIB_1907	COG0649	NAD binding
TSIB_1907	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TSIB_1908	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TSIB_1909	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TSIB_1911	COG0651	ATP synthesis coupled electron transport
TSIB_1913	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TSIB_1913	COG2111	Na H antiporter
TSIB_1915	COG1320	monovalent cation:proton antiporter activity
TSIB_1916	COG2212	antiporter activity
TSIB_1917	COG1863	multisubunit Na H antiporter MnhE subunit
TSIB_1921	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TSIB_1925	COG0018	arginyl-trna synthetase
TSIB_1926	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TSIB_1949	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TSIB_1954	COG1047	Peptidyl-prolyl cis-trans
TSIB_1962	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TSIB_1962	COG0116	Belongs to the methyltransferase superfamily
TSIB_1963	COG0179	Fumarylacetoacetate (FAA) hydrolase
TSIB_1965	COG0045	succinate-CoA ligase (ADP-forming) activity
TSIB_1965	COG1042	CoA-binding domain protein
TSIB_1965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TSIB_1966	COG0640	Transcriptional regulator
TSIB_1969	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TSIB_1969	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TSIB_1979	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TSIB_1979	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TSIB_1980	COG0402	S-adenosylhomocysteine deaminase activity
TSIB_1981	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TSIB_1984	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TSIB_1991	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
TSIB_1993	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TSIB_1998	COG1028	Short-chain dehydrogenase reductase Sdr
TSIB_1999	COG1881	PFAM PEBP family protein
TSIB_2009	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
TSIB_2017	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TSIB_2021	COG0297	glycogen (starch) synthase activity
TSIB_2021	COG0438	transferase activity, transferring glycosyl groups
TSIB_2023	COG0367	asparagine synthase
TSIB_2026	COG1215	transferase activity, transferring glycosyl groups
TSIB_2032	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TSIB_2035	COG1373	ATPase (AAA superfamily
TSIB_2037	COG2046	Belongs to the sulfate adenylyltransferase family
TSIB_2037	COG0529	Catalyzes the synthesis of activated sulfate
TSIB_2050	COG0463	Glycosyl transferase, family 2
TSIB_2061	COG0438	transferase activity, transferring glycosyl groups
TSIB_2061	COG0297	glycogen (starch) synthase activity