locus-tag	class	description
TAM4_1	ENOG410849U	50S ribosomal protein L30
TAM4_101	ENOG4105DK7	lysyl-tRNA synthetase
TAM4_1010	ENOG4105CB5	ATP-dependent DNA helicase recG
TAM4_1028	ENOG4105KJM	monovalent cation h antiporter subunit g
TAM4_1030	ENOG41081HM	2'-5' rna ligase
TAM4_1034	ENOG4105CD5	CoA-binding domain protein
TAM4_104	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
TAM4_1044	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
TAM4_1046	ENOG4108JPZ	Monovalent cation H antiporter subunit D
TAM4_1048	ENOG4108JPZ	Monovalent cation H antiporter subunit D
TAM4_1050	ENOG4105DIW	FeS assembly protein SUFB
TAM4_1051	ENOG4105MKQ	Monovalent cation H antiporter subunit C
TAM4_1054	ENOG4105QAX	Iron-sulfur
TAM4_106	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
TAM4_1066	ENOG4105SC1	monovalent cation H antiporter subunit E
TAM4_1067	ENOG4105CJG	carbon-monoxide dehydrogenase catalytic subunit
TAM4_1071	ENOG4107TDF	Formate hydrogenlyase subunit 4
TAM4_1073	ENOG4107WCI	zn-dependent hydrolase of the beta-lactamase fold-like protein
TAM4_1075	ENOG4105VG1	fes assembly suf system protein
TAM4_1077	ENOG4108JVH	Protein of unknown function DUF43
TAM4_1081	ENOG4108IUZ	ABC transporter
TAM4_1087	ENOG4105C47	NADH ubiquinone oxidoreductase 20 kda subunit
TAM4_109	ENOG4105JNK	Glycosyl transferase (Group 1
TAM4_1090	ENOG4105BZ8	glutamate synthase
TAM4_1091	ENOG41084T3	4fe-4S ferredoxin iron-sulfur binding domain-containing protein
TAM4_1096	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
TAM4_1098	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
TAM4_1100	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
TAM4_1100	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
TAM4_1103	ENOG4107RDB	Major Facilitator
TAM4_111	ENOG4105CKP	Polysaccharide Biosynthesis Protein
TAM4_1110	ENOG4108IEG	Formate dehydrogenase Alpha subunit
TAM4_1111	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
TAM4_1115	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
TAM4_112	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
TAM4_1123	ENOG4108HW3	(ABC) transporter
TAM4_1125	ENOG4105CTD	carboxy-peptidase
TAM4_1126	ENOG4105C3U	ABC transporter
TAM4_1127	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
TAM4_113	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
TAM4_1130	ENOG4105QAX	Iron-sulfur
TAM4_1133	ENOG4105C45	hydrogenase expression formation protein (HypE)
TAM4_1134	ENOG4105C47	NADH ubiquinone oxidoreductase 20 kda subunit
TAM4_1135	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
TAM4_1136	ENOG4105E4P	ATPase (AAA
TAM4_1138	ENOG4107XF7	NGG1p interacting factor 3 protein, NIF3
TAM4_1139	ENOG4107TDF	Formate hydrogenlyase subunit 4
TAM4_114	ENOG4105DF0	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity)
TAM4_1140	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
TAM4_1143	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
TAM4_1145	ENOG4108RG7	formate hydrogenlyase complex iron-sulfur subunit
TAM4_1147	ENOG41080HI	glycine oxidase
TAM4_1149	ENOG4107QT7	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
TAM4_1151	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
TAM4_1155	ENOG4105CDA	abc transporter atp-binding protein
TAM4_1158	ENOG4105C47	NADH ubiquinone oxidoreductase 20 kda subunit
TAM4_1159	ENOG4105BZG	amino acid carrier protein
TAM4_1160	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
TAM4_1161	ENOG4105WRB	Hydrogenase assembly chaperone hypC hupF
TAM4_1166	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
TAM4_1169	ENOG4107S5Z	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity)
TAM4_1172	ENOG4108JJB	ABC transporter
TAM4_1173	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
TAM4_1177	ENOG4108JPZ	Monovalent cation H antiporter subunit D
TAM4_1178	ENOG4105C31	Tryptophanyl-tRNA synthetase
TAM4_118	ENOG4108UPS	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity)
TAM4_1188	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
TAM4_1192	ENOG4105C3D	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
TAM4_1195	ENOG4105K4G	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
TAM4_1196	ENOG41067SE	Tetr family transcriptional regulator
TAM4_1197	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
TAM4_120	ENOG4105C5R	Aminotransferase
TAM4_1200	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
TAM4_121	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
TAM4_1210	ENOG4107NFR	Fructose-1,6-bisphosphatase
TAM4_1213	ENOG4105MKQ	Monovalent cation H antiporter subunit C
TAM4_1214	ENOG4108ZAF	Molybdopterin
TAM4_1218	ENOG4105CY0	Metallo-Beta-Lactamase
TAM4_1219	ENOG4105C0H	protease
TAM4_122	ENOG4107Y49	methyltransferase
TAM4_1225	ENOG4108JPW	Aminotransferase
TAM4_1228	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
TAM4_1230	ENOG4105EHU	Circadian clock protein KaiC
TAM4_1231	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
TAM4_1233	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
TAM4_1236	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
TAM4_1237	ENOG4105EAD	ABC transporter
TAM4_1239	ENOG4105D65	subunit l
TAM4_1240	ENOG4105CD3	dihydroorotase
TAM4_1241	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
TAM4_1246	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
TAM4_1247	ENOG4105DF0	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity)
TAM4_1248	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
TAM4_1249	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
TAM4_1259	ENOG4105EW9	transcriptional regulator AsnC family
TAM4_1264	ENOG4107QXV	Phosphate transporter
TAM4_1269	ENOG4108JPW	Aminotransferase
TAM4_127	ENOG4108VVK	transcriptional Regulator, AsnC
TAM4_1272	ENOG4105EYW	Ion transport protein
TAM4_1275	ENOG4107TDF	Formate hydrogenlyase subunit 4
TAM4_1276	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
TAM4_1277	ENOG4105C3M	thioredoxin reductase
TAM4_1279	ENOG4105CB1	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
TAM4_1286	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
TAM4_1288	ENOG4107GFK	fumarate
TAM4_1295	ENOG41082SX	arsR family transcriptional regulator
TAM4_1296	ENOG41080XS	Cobyrinic acid ac-diamide synthase
TAM4_13	ENOG4107QJE	Chromosome Partitioning Protein
TAM4_1305	ENOG4108IGT	Dipeptidase
TAM4_1308	ENOG4107RWR	Sodium hydrogen exchanger
TAM4_1318	ENOG4105CUT	histidyl-tRNA synthetase
TAM4_1322	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
TAM4_1328	ENOG410704R	Produces ATP from ADP in the presence of a proton gradient across the membrane
TAM4_1329	ENOG4107W7X	Aldolase
TAM4_133	ENOG4105E66	phosphoriboisomerase A
TAM4_1330	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
TAM4_1331	ENOG4105CQS	hydrogenase expression formation protein HypD
TAM4_1335	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
TAM4_1338	ENOG4108JIQ	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity)
TAM4_1339	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
TAM4_134	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
TAM4_1342	ENOG4105CYV	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity)
TAM4_1346	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
TAM4_1348	ENOG4108JQ1	Dehydrogenase
TAM4_135	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
TAM4_1351	ENOG4108UUC	Protein of unknown function DUF99
TAM4_1362	ENOG4108RVA	ribokinase
TAM4_1364	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
TAM4_1367	ENOG4105K6H	D-cysteine desulfhydrase
TAM4_1368	ENOG4107YZX	Universal stress protein
TAM4_137	ENOG4105C5I	Dehydrogenase
TAM4_1377	ENOG4108HM5	NADH-ubiquinone oxidoreductase chain 49kDa
TAM4_1381	ENOG4105W4C	monovalent cation H antiporter subunit F
TAM4_1382	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
TAM4_1384	ENOG4105KJM	monovalent cation h antiporter subunit g
TAM4_1385	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
TAM4_1386	ENOG4105DDK	oxidoreductase, beta subunit
TAM4_1387	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
TAM4_1389	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
TAM4_1390	ENOG4105C5F	glutamine synthetase
TAM4_1391	ENOG41083NF	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
TAM4_1396	ENOG4105MRR	Transcriptional regulator (By similarity)
TAM4_1398	ENOG4105DDK	oxidoreductase, beta subunit
TAM4_1399	ENOG4105DZ0	fad dependent oxidoreductase
TAM4_1401	ENOG4105D1F	ATP-binding protein
TAM4_1411	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
TAM4_1412	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
TAM4_1419	ENOG4108JPZ	Monovalent cation H antiporter subunit D
TAM4_1422	ENOG4105D1H	recombination factor protein RarA
TAM4_1434	ENOG4105C4K	Nad synthetase
TAM4_1436	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
TAM4_1439	ENOG4108KN7	Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity)
TAM4_1444	ENOG4105ERH	Fumarylacetoacetate hydrolase
TAM4_1449	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
TAM4_1450	ENOG4108IFG	nitrite reductase, (NAD(P)H)
TAM4_1451	ENOG4107RWR	Sodium hydrogen exchanger
TAM4_1452	ENOG4108JQ7	(ABC) transporter
TAM4_1454	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
TAM4_1455	ENOG4105E5Q	amino acid AbC transporter
TAM4_1457	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
TAM4_1459	ENOG4108T9W	RNA methylase
TAM4_1460	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
TAM4_1473	ENOG4105HDK	L-asparaginase
TAM4_1476	ENOG4105D44	asparaginase
TAM4_1477	ENOG4105DSE	periplasmic solute binding protein
TAM4_1482	ENOG4107QR0	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
TAM4_1485	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
TAM4_1486	ENOG4105KPK	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
TAM4_1487	ENOG4105C8N	cysteinyl-tRNA synthetase
TAM4_1494	ENOG41065SU	Two-component system sensor kinase
TAM4_1495	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
TAM4_1498	ENOG4107R76	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
TAM4_15	ENOG4105C6W	4-alpha-glucanotransferase (EC 2.4.1.25)
TAM4_1501	ENOG4105KRN	Transcriptional regulator, abrb family
TAM4_1503	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
TAM4_1505	ENOG4105ECW	sulfate abc transporter
TAM4_1506	ENOG4107QW4	alcohol dehydrogenase
TAM4_151	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
TAM4_1512	ENOG4107YTP	response regulator receiver protein
TAM4_1514	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
TAM4_1516	ENOG4107RFW	hydrolase family 57
TAM4_1517	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
TAM4_1525	ENOG4105CIH	Imidazole acetol-phosphate transaminase
TAM4_1526	ENOG4105UIB	(ABC) transporter
TAM4_1529	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
TAM4_153	ENOG4105C8T	Leucyl-tRNA synthetase
TAM4_1533	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
TAM4_1536	ENOG4105EEI	dihydropteroate synthase
TAM4_1541	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
TAM4_1545	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
TAM4_1547	ENOG4105C2X	Arabinose 5-phosphate isomerase
TAM4_1548	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
TAM4_1549	ENOG4107XGZ	Hydrolase
TAM4_155	ENOG4105NBF	ammecr1 domain protein
TAM4_1557	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
TAM4_1561	ENOG4105C83	adenylosuccinate lyase
TAM4_1562	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
TAM4_1567	ENOG4107WZZ	SMC domain protein
TAM4_1567	ENOG4107WZZ	SMC domain protein
TAM4_1568	ENOG4105DZR	Type I site-specific deoxyribonuclease
TAM4_157	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
TAM4_1572	ENOG4105DZA	Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity)
TAM4_1574	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
TAM4_1578	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
TAM4_1579	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
TAM4_158	ENOG41076HS	cation diffusion facilitator family transporter
TAM4_1582	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
TAM4_1587	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
TAM4_159	ENOG4105E4P	ATPase (AAA
TAM4_1590	ENOG4105C8J	)-transporter
TAM4_1594	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
TAM4_1600	ENOG4105NBF	ammecr1 domain protein
TAM4_1608	ENOG4105DJB	Major Facilitator Superfamily
TAM4_1614	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
TAM4_1620	ENOG4108R6G	acetyltransferase
TAM4_1622	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
TAM4_1624	ENOG41061GT	Aldolase
TAM4_163	ENOG4105VXP	Protein of unknown function DUF86
TAM4_1633	ENOG4105WMR	Protein CrcB homolog
TAM4_1634	ENOG4108IYI	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
TAM4_1635	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
TAM4_1638	ENOG4105D9P	serine threonine protein kinase
TAM4_165	ENOG4108YXU	transcriptional regulator AsnC family
TAM4_1650	ENOG4107Y70	Heat shock protein
TAM4_1651	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
TAM4_1653	ENOG4108R96	Methyltransferase, YaeB family
TAM4_1655	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
TAM4_1663	ENOG4105EPU	Molybdenum cofactor synthesis domain protein
TAM4_1664	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
TAM4_1669	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
TAM4_1673	ENOG4106K5Q	Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity)
TAM4_1676	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
TAM4_1688	ENOG4108JQ9	ABC transporter
TAM4_1694	ENOG4105E0C	molybdate abc transporter
TAM4_1697	ENOG4108V1U	phospholipid-binding protein
TAM4_17	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
TAM4_1701	ENOG4107RGW	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TAM4_1708	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
TAM4_1710	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
TAM4_1713	ENOG4105DIH	basic membrane
TAM4_1715	ENOG4105E4P	ATPase (AAA
TAM4_1716	ENOG4107TH8	cina domain protein
TAM4_1722	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
TAM4_1726	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
TAM4_1729	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
TAM4_1733	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
TAM4_1734	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
TAM4_1739	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
TAM4_1741	ENOG4107UX3	phosphatidylethanolamine N-methyltransferase
TAM4_1743	ENOG4107S6Z	Na H antiporter
TAM4_1747	ENOG4105CQ2	DNA polymerase
TAM4_1755	ENOG4105CBS	Chea signal transduction histidine kinase
TAM4_1757	ENOG4107XZC	Restriction modification system DNA (Specificity
TAM4_1762	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
TAM4_1763	ENOG4105KJJ	Uncharacterized ACR, COG1993
TAM4_1764	ENOG4105DT1	RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate
TAM4_1767	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
TAM4_1772	ENOG4105CY0	Metallo-Beta-Lactamase
TAM4_1773	ENOG4105F4G	Membrane
TAM4_1775	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
TAM4_1776	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
TAM4_1778	ENOG4108HJF	gCN5-related N-acetyltransferase
TAM4_1779	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
TAM4_178	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
TAM4_1786	ENOG4107TE1	transport protein
TAM4_1788	ENOG4107QSA	Oxaloacetate decarboxylase
TAM4_1790	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
TAM4_1791	ENOG41066FR	extracellular solute-binding protein
TAM4_1793	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
TAM4_1794	ENOG4105VZ9	UPF0235 protein
TAM4_1795	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
TAM4_1796	ENOG4105CK2	sodium dicarboxylate symporter
TAM4_1798	ENOG4105CJ1	ABC, transporter
TAM4_1800	ENOG4108MWI	inositol mono-phosphatase
TAM4_1803	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
TAM4_1805	ENOG4107RWR	Sodium hydrogen exchanger
TAM4_181	ENOG4105CNB	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
TAM4_1813	ENOG4107QRT	dEAD DEAH box helicase
TAM4_1814	ENOG4105VUN	Transcriptional regulator
TAM4_1818	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
TAM4_1819	ENOG4108I5U	Uridine phosphorylase
TAM4_1822	ENOG4105CX6	glutaminyL-tRNA synthetase
TAM4_1825	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
TAM4_1833	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
TAM4_1834	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
TAM4_1835	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
TAM4_1838	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
TAM4_1842	ENOG4105BZR	domain protein
TAM4_1845	ENOG41074MP	UPF0103 Mediator of ErbB2-driven cell motility-containing protein
TAM4_1848	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
TAM4_1850	ENOG4105DP9	ABC transporter
TAM4_1857	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
TAM4_1859	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
TAM4_1861	ENOG4105DBV	ornithine carbamoyltransferase
TAM4_1864	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
TAM4_1866	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
TAM4_1872	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
TAM4_1873	ENOG4108JJB	ABC transporter
TAM4_188	ENOG4105CXT	aspartate transcarbamylase
TAM4_1880	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
TAM4_1882	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
TAM4_1885	ENOG4105DCI	Phosphohydrolase
TAM4_1887	ENOG4105F8V	Hydrolase, tatD family
TAM4_1892	ENOG4108YZ8	Superoxide reductase
TAM4_1894	ENOG4108JPZ	Monovalent cation H antiporter subunit D
TAM4_1895	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
TAM4_1903	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
TAM4_1905	ENOG4108JU3	Alkyl hydroperoxide reductase
TAM4_1909	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
TAM4_1917	ENOG4105E7W	lamb ycsf family protein
TAM4_192	ENOG4105VAW	lrga family
TAM4_1920	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TAM4_1922	ENOG4105D65	subunit l
TAM4_1924	ENOG4105U0R	haloacid dehalogenase-like hydrolase
TAM4_193	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TAM4_1930	ENOG4108WBT	adenosyltransferase
TAM4_1931	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
TAM4_1934	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
TAM4_1935	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
TAM4_1936	ENOG4105P4J	Allophanate hydrolase, subunit 1
TAM4_1941	ENOG4105DQU	oxidoreductase, subunit beta
TAM4_1942	ENOG4108R6K	riboflavin synthase, subunit alpha
TAM4_1943	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
TAM4_1945	ENOG4105CPQ	Dehydrogenase
TAM4_1948	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
TAM4_195	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
TAM4_1954	ENOG41087GE	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
TAM4_1955	ENOG4105F4P	)-transporter
TAM4_1957	ENOG4108JPZ	Monovalent cation H antiporter subunit D
TAM4_1958	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
TAM4_1967	ENOG4105CD5	CoA-binding domain protein
TAM4_1983	ENOG41090A1	ferritin
TAM4_1988	ENOG4105BZA	Phosphoglycerate kinase
TAM4_199	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
TAM4_1992	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
TAM4_1993	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
TAM4_20	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
TAM4_2000	ENOG4105C4M	(Ubiquinol oxidase) subunit I
TAM4_2005	ENOG4105CHM	Aminotransferase
TAM4_2014	ENOG4107SA6	carbon-phosphorus lyase complex accessory protein
TAM4_2017	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
TAM4_2019	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
TAM4_2021	ENOG4105DCI	Phosphohydrolase
TAM4_2024	ENOG4105CH2	amidohydrolase
TAM4_2025	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
TAM4_2028	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
TAM4_2029	ENOG4105SC1	monovalent cation H antiporter subunit E
TAM4_203	ENOG4105C5S	asparaginyl-tRNA synthetase
TAM4_2030	ENOG4108RCS	geranylgeranylglyceryl phosphate synthase
TAM4_2039	ENOG4108JIU	phosphoribosylformylglycinamidine synthase ii
TAM4_204	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
TAM4_2042	ENOG4105VCQ	rubredoxin
TAM4_2044	ENOG4108RAC	Rubrerythrin
TAM4_205	ENOG4108Z24	l-2,4-diaminobutyric acid acetyltransferase
TAM4_2050	ENOG4105D7T	ABC transporter
TAM4_2055	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
TAM4_2056	ENOG4105ZHF	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
TAM4_2057	ENOG4105CG9	aspartate racemase
TAM4_206	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
TAM4_2062	ENOG4105D64	Mechanosensitive ion channel
TAM4_2063	ENOG4105DIK	(ABC) transporter
TAM4_2070	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
TAM4_2072	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
TAM4_2077	ENOG4105CD5	CoA-binding domain protein
TAM4_2078	ENOG4105VZ8	Transcriptional regulator
TAM4_208	ENOG41080UE	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
TAM4_2081	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
TAM4_2085	ENOG4105CSM	endonuclease III
TAM4_2089	ENOG4105CJ1	ABC, transporter
TAM4_2092	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
TAM4_2096	ENOG4105D3R	alkyl hydroperoxide reductase
TAM4_2097	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
TAM4_2101	ENOG4105CE1	Ferrous iron transport protein b
TAM4_2108	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
TAM4_2118	ENOG4107QVT	Binding-protein-dependent transport systems, inner membrane component
TAM4_2124	ENOG4105KNA	-acetyltransferase
TAM4_2126	ENOG4108ZF3	Phosphatase
TAM4_2128	ENOG4105CNW	domain protein
TAM4_2130	ENOG4105C1J	atp-dependent rna helicase
TAM4_2138	ENOG4108VVK	transcriptional Regulator, AsnC
TAM4_214	ENOG4105D9Q	decarboxylase (Beta subunit)
TAM4_2143	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
TAM4_2149	ENOG4108K3F	N(2),N(2)-dimethylguanosine tRNA methyltransferase
TAM4_215	ENOG4105KPK	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
TAM4_2151	ENOG4107R8N	Glycosyl transferase, family 2
TAM4_2152	ENOG4105DC7	peptidase M24
TAM4_2153	ENOG4105CJ3	phosphate transporter
TAM4_2157	ENOG4105MKQ	Monovalent cation H antiporter subunit C
TAM4_2160	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
TAM4_2164	ENOG4105E7Q	Cob(II)yrinic acid a,c-diamide reductase
TAM4_2165	ENOG4105CHR	reductase
TAM4_217	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
TAM4_2178	ENOG4105EAH	synthase
TAM4_218	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
TAM4_2183	ENOG4105EHG	Permease protein
TAM4_2186	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
TAM4_2188	ENOG4105DQU	oxidoreductase, subunit beta
TAM4_2190	ENOG4107UX3	phosphatidylethanolamine N-methyltransferase
TAM4_2191	ENOG4108JJB	ABC transporter
TAM4_2194	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
TAM4_2197	ENOG4107S7U	Sulfide dehydrogenase
TAM4_2199	ENOG4108J2R	molybdopterin oxidoreductase
TAM4_2206	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
TAM4_2209	ENOG4105EM7	Selenocysteine-specific translation elongation factor
TAM4_2210	ENOG4105DER	m42 family
TAM4_2213	ENOG4105N80	Ferric uptake regulator, Fur family
TAM4_222	ENOG4107QMS	site-determining protein
TAM4_223	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
TAM4_226	ENOG4106UJV	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
TAM4_2323	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
TAM4_2327	ENOG4105D9P	serine threonine protein kinase
TAM4_2331	ENOG4105D9P	serine threonine protein kinase
TAM4_2334	ENOG4105D9P	serine threonine protein kinase
TAM4_2346	ENOG4108UK2	deaminase
TAM4_2347	ENOG4108Y83	glucose-6-phosphate isomerase
TAM4_2348	ENOG4108Z4T	Peptidase M50
TAM4_2355	ENOG4108RWI	nicotinamidase
TAM4_2371	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
TAM4_2383	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
TAM4_2387	ENOG4106IPI	cyclase, family
TAM4_2425	ENOG4108R9M	Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity)
TAM4_2433	ENOG4105K64	Glycosyl transferase, family 2
TAM4_2441	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
TAM4_2446	ENOG4105CJ3	phosphate transporter
TAM4_245	ENOG4105CTP	PilT protein domain protein
TAM4_2460	ENOG4105CDJ	oxidoreductase FAD NAD(P)-binding domain protein
TAM4_247	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
TAM4_2470	ENOG4105VYW	UPF0251 protein
TAM4_2471	ENOG4105DZH	s-adenosylmethionine synthetase (EC 2.5.1.6)
TAM4_2472	ENOG4108JQ7	(ABC) transporter
TAM4_2473	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
TAM4_250	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
TAM4_251	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
TAM4_252	ENOG4108J9M	Transporter
TAM4_254	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
TAM4_256	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TAM4_26	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
TAM4_261	ENOG4105C2X	Arabinose 5-phosphate isomerase
TAM4_263	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
TAM4_270	ENOG4105CMW	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)
TAM4_272	ENOG4108UJD	30S ribosomal protein S9
TAM4_273	ENOG4105DC7	peptidase M24
TAM4_277	ENOG4108ZJT	translation initiation factor, Sui1
TAM4_28	ENOG4105D8K	carboxyl transferase
TAM4_285	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
TAM4_288	ENOG4108JEB	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
TAM4_289	ENOG4105C5S	asparaginyl-tRNA synthetase
TAM4_293	ENOG4107R56	PP-loop domain protein
TAM4_294	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
TAM4_299	ENOG4107V9E	glucose-1-phosphate thymidylyltransferase
TAM4_3	ENOG41067MG	lrgb family
TAM4_303	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
TAM4_306	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
TAM4_309	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
TAM4_312	ENOG4105CAQ	asparagine synthetase
TAM4_313	ENOG41076QQ	Glycosyl transferase, family 2
TAM4_318	ENOG4105EAH	synthase
TAM4_319	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
TAM4_32	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
TAM4_321	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TAM4_323	ENOG4105CDU	Replicative dna helicase
TAM4_324	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
TAM4_327	ENOG4108HWH	(ABC) transporter
TAM4_33	ENOG4107QSA	Oxaloacetate decarboxylase
TAM4_335	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
TAM4_339	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
TAM4_340	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TAM4_346	ENOG4105C9B	Cysteine desulfurase
TAM4_347	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
TAM4_356	ENOG4105FDK	ABC transporter
TAM4_358	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
TAM4_36	ENOG4105CHM	Aminotransferase
TAM4_363	ENOG4107QIZ	NADH dehydrogenase
TAM4_364	ENOG41082SA	50s ribosomal protein l29
TAM4_365	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
TAM4_366	ENOG4108Z4J	Cytidine monophosphate kinase
TAM4_367	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
TAM4_369	ENOG4105D82	Glutamate dehydrogenase
TAM4_370	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
TAM4_376	ENOG4105EMU	Dehydrogenase
TAM4_378	ENOG4105D6E	homoserine dehydrogenase
TAM4_384	ENOG4107SW0	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
TAM4_390	ENOG4105D4M	Lactamase_B
TAM4_40	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
TAM4_416	ENOG4107R7Y	intracellular protease Pfpi family
TAM4_420	ENOG4105D0M	Protease HtpX homolog
TAM4_421	ENOG4105EW9	transcriptional regulator AsnC family
TAM4_423	ENOG4107XGZ	Hydrolase
TAM4_424	ENOG4105CHM	Aminotransferase
TAM4_429	ENOG4105Y7X	Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity)
TAM4_43	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
TAM4_433	ENOG4105HDK	L-asparaginase
TAM4_434	ENOG4108UHF	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
TAM4_435	ENOG4108K7V	UPF0284 protein
TAM4_436	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
TAM4_437	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
TAM4_44	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
TAM4_441	ENOG4105D0M	Protease HtpX homolog
TAM4_442	ENOG4108JQ7	(ABC) transporter
TAM4_445	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
TAM4_447	ENOG4105CN9	Peptidase m42 family protein
TAM4_448	ENOG4105E4P	ATPase (AAA
TAM4_456	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
TAM4_459	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
TAM4_462	ENOG4105FJR	Lmbe family
TAM4_463	ENOG4105CDJ	oxidoreductase FAD NAD(P)-binding domain protein
TAM4_466	ENOG4105CHU	acetyl-coa acetyltransferase
TAM4_467	ENOG4105CMQ	Chloride channel
TAM4_473	ENOG4107QX8	SPFH domain, Band 7 family protein
TAM4_474	ENOG4105SC1	monovalent cation H antiporter subunit E
TAM4_475	ENOG4108IUK	alpha amylase, catalytic
TAM4_477	ENOG4105D65	subunit l
TAM4_484	ENOG4105C75	arginyL-tRNA synthetase
TAM4_485	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
TAM4_487	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
TAM4_489	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
TAM4_492	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
TAM4_493	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
TAM4_499	ENOG4105D9P	serine threonine protein kinase
TAM4_5	ENOG4108Y5D	Inherit from COG: cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
TAM4_501	ENOG4105D1Z	hydroxypyruvate reductase
TAM4_505	ENOG4105CPK	Glycosyl transferase (Group 1
TAM4_506	ENOG4105C11	sulfate adenylyltransferase), subunit 2
TAM4_510	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
TAM4_514	ENOG4105CN9	Peptidase m42 family protein
TAM4_517	ENOG410667J	hydrolase
TAM4_526	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
TAM4_532	ENOG4105UQX	Mate efflux family protein
TAM4_534	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
TAM4_536	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
TAM4_537	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
TAM4_54	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
TAM4_544	ENOG4108IYU	L-aspartate oxidase
TAM4_549	ENOG4105TPC	MazG nucleotide pyrophosphohydrolase domain
TAM4_55	ENOG4105CE9	30S ribosomal protein S2
TAM4_550	ENOG4105CN9	Peptidase m42 family protein
TAM4_553	ENOG4108HH9	Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR
TAM4_556	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
TAM4_558	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
TAM4_56	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
TAM4_561	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
TAM4_57	ENOG4108Z03	MAF-like protein
TAM4_571	ENOG4107QSQ	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
TAM4_574	ENOG4105DIW	FeS assembly protein SUFB
TAM4_576	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
TAM4_578	ENOG4105G01	cobalamin (vitamin B12) biosynthesis CbiM protein
TAM4_582	ENOG4105CJG	carbon-monoxide dehydrogenase catalytic subunit
TAM4_583	ENOG4105CD5	CoA-binding domain protein
TAM4_591	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
TAM4_592	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
TAM4_594	ENOG4105BZ8	glutamate synthase
TAM4_598	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
TAM4_6	ENOG4105CKX	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP
TAM4_600	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
TAM4_601	ENOG4108M14	stage v sporulation protein t
TAM4_607	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
TAM4_608	ENOG4105BZ8	glutamate synthase
TAM4_61	ENOG4105EHG	Permease protein
TAM4_610	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
TAM4_614	ENOG4108JJB	ABC transporter
TAM4_616	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
TAM4_626	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
TAM4_63	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
TAM4_630	ENOG4105E5G	Alpha beta hydrolase fold
TAM4_632	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
TAM4_634	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
TAM4_635	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
TAM4_640	ENOG4105G01	cobalamin (vitamin B12) biosynthesis CbiM protein
TAM4_646	ENOG4105K8R	UPF0145 protein
TAM4_647	ENOG4105EG2	ABC transporter, permease
TAM4_648	ENOG41084T3	4fe-4S ferredoxin iron-sulfur binding domain-containing protein
TAM4_660	ENOG4105E0R	Deoxyhypusine synthase
TAM4_661	ENOG4108JPZ	Monovalent cation H antiporter subunit D
TAM4_662	ENOG4105DEF	Extracellular solute-binding protein, family 5
TAM4_665	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
TAM4_666	ENOG4105EHU	Circadian clock protein KaiC
TAM4_668	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
TAM4_669	ENOG4105G0J	serine threonine protein kinase
TAM4_679	ENOG4105IIU	Aminopeptidase
TAM4_681	ENOG4108JPZ	Monovalent cation H antiporter subunit D
TAM4_683	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
TAM4_685	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
TAM4_688	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
TAM4_691	ENOG4105F0N	pyrophosphate phospho-hydrolase
TAM4_697	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
TAM4_704	ENOG4105EAC	phosphoserine phosphatase
TAM4_706	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
TAM4_707	ENOG4108ZF3	Phosphatase
TAM4_712	ENOG4108I5C	dEAD DEAH box helicase
TAM4_713	ENOG4105C22	threonyL-tRNA synthetase
TAM4_714	ENOG4108Z0R	Transferase
TAM4_716	ENOG4105C8V	SAICAR synthetase
TAM4_719	ENOG4105QAX	Iron-sulfur
TAM4_720	ENOG4105D9P	serine threonine protein kinase
TAM4_721	ENOG4105C3G	gtp-binding protein
TAM4_722	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
TAM4_729	ENOG4107TSN	permease
TAM4_732	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
TAM4_735	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
TAM4_742	ENOG4105DHP	deoxycytidine triphosphate deaminase
TAM4_745	ENOG4107QI1	Mate efflux family protein
TAM4_750	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
TAM4_753	ENOG4105C5S	asparaginyl-tRNA synthetase
TAM4_754	ENOG41080XS	Cobyrinic acid ac-diamide synthase
TAM4_756	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
TAM4_759	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
TAM4_766	ENOG4105QAX	Iron-sulfur
TAM4_769	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
TAM4_771	ENOG4108NGU	Transcriptional regulator
TAM4_772	ENOG4107104	thymidine kinase
TAM4_774	ENOG4107QNG	Phosphoribosylglycinamide synthetase
TAM4_776	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
TAM4_778	ENOG4107QVT	Binding-protein-dependent transport systems, inner membrane component
TAM4_786	ENOG4105E0A	ABC, transporter
TAM4_79	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
TAM4_790	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
TAM4_791	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
TAM4_795	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
TAM4_796	ENOG4105CIG	ABC transporter
TAM4_8	ENOG4105C1J	atp-dependent rna helicase
TAM4_801	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
TAM4_803	ENOG4108RMN	UPF0128 protein
TAM4_807	ENOG4105K4P	CoA-binding domain protein
TAM4_816	ENOG4105D56	permease protein
TAM4_818	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
TAM4_819	ENOG4105CND	Glycosyl transferase, family 2
TAM4_824	ENOG4105C7N	Xanthine uracil vitamin C permease
TAM4_827	ENOG4108UKZ	OsmC family
TAM4_835	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
TAM4_841	ENOG4108ESU	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity)
TAM4_843	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
TAM4_846	ENOG4108T9Q	UPF0278 protein
TAM4_847	ENOG4107R21	site-determining protein
TAM4_85	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
TAM4_852	ENOG4105DR4	Methyltransferase
TAM4_853	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TAM4_854	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
TAM4_859	ENOG4105BZ8	glutamate synthase
TAM4_860	ENOG4105CNB	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
TAM4_862	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
TAM4_864	ENOG4105KJM	monovalent cation h antiporter subunit g
TAM4_867	ENOG4108XM1	transcriptional regulator AsnC family
TAM4_869	ENOG4105E3H	phosphoglycerate mutase
TAM4_872	ENOG4105C98	muts2 protein
TAM4_874	ENOG4105KME	endoribonuclease L-psp
TAM4_878	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
TAM4_879	ENOG4105UQX	Mate efflux family protein
TAM4_885	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
TAM4_888	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
TAM4_893	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
TAM4_9	ENOG4107QX8	SPFH domain, Band 7 family protein
TAM4_90	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
TAM4_902	ENOG4105CS2	ec 3.2.1.21
TAM4_903	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
TAM4_909	ENOG4105C5I	Dehydrogenase
TAM4_910	ENOG4105CIG	ABC transporter
TAM4_911	ENOG4105GSQ	TM1410 hypothetical-related protein
TAM4_912	ENOG4105D64	Mechanosensitive ion channel
TAM4_918	ENOG4105MKQ	Monovalent cation H antiporter subunit C
TAM4_920	ENOG4105C3K	feS assembly ATPase SufC
TAM4_923	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
TAM4_925	ENOG4108VVK	transcriptional Regulator, AsnC
TAM4_927	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
TAM4_928	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
TAM4_93	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
TAM4_930	ENOG410684G	monovalent cation H antiporter subunit F
TAM4_934	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
TAM4_937	ENOG4105PW4	Sugar fermentation stimulation protein homolog
TAM4_938	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TAM4_943	ENOG4105C3U	ABC transporter
TAM4_947	ENOG4105D9P	serine threonine protein kinase
TAM4_949	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
TAM4_95	ENOG4105CB1	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
TAM4_956	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
TAM4_959	ENOG4105D9P	serine threonine protein kinase
TAM4_960	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
TAM4_963	ENOG4105DUN	Mediates zinc uptake. May also transport other divalent cations (By similarity)
TAM4_967	ENOG4107FKK	extracellular solute-binding protein family 1
TAM4_972	ENOG4107QRT	dEAD DEAH box helicase
TAM4_972	ENOG4107QRT	dEAD DEAH box helicase
TAM4_973	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
TAM4_975	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
TAM4_978	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
TAM4_979	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TAM4_981	ENOG4105D22	carbon starvation protein
TAM4_983	ENOG4105CIH	Imidazole acetol-phosphate transaminase
TAM4_984	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
TAM4_986	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
TAM4_987	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
TAM4_991	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TAM4_993	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
TAM4_994	ENOG4105C2X	Arabinose 5-phosphate isomerase