locus-tag	class	description
TAM4_1	COG1841	ribosomal large subunit assembly
TAM4_101	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
TAM4_1030	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TAM4_1034	COG0045	succinate-CoA ligase (ADP-forming) activity
TAM4_1034	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TAM4_1034	COG1042	CoA-binding domain protein
TAM4_104	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TAM4_1044	COG0175	sulfate reduction
TAM4_1046	COG0651	ATP synthesis coupled electron transport
TAM4_1048	COG0651	ATP synthesis coupled electron transport
TAM4_1050	COG0719	Fe-S assembly protein
TAM4_1051	COG1006	Multisubunit Na H antiporter MnhC subunit
TAM4_1054	COG0437	4 iron, 4 sulfur cluster binding
TAM4_106	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TAM4_106	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TAM4_1063	COG2212	antiporter activity
TAM4_1067	COG1151	hydroxylamine reductase activity
TAM4_1071	COG0650	Formate hydrogenlyase subunit 4
TAM4_1073	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TAM4_1075	COG2151	metal-sulfur cluster biosynthetic enzyme
TAM4_1081	COG1137	ATPase activity
TAM4_1087	COG3260	NADH ubiquinone oxidoreductase 20
TAM4_109	COG0438	transferase activity, transferring glycosyl groups
TAM4_1090	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TAM4_1090	COG0493	'glutamate synthase
TAM4_1091	COG1141	Ferredoxin
TAM4_1096	COG1404	Belongs to the peptidase S8 family
TAM4_1098	COG3261	NADH dehydrogenase
TAM4_1098	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
TAM4_1100	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TAM4_1100	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TAM4_1103	COG2814	Major facilitator Superfamily
TAM4_1104	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TAM4_111	COG2244	polysaccharide biosynthetic process
TAM4_1110	COG3383	formate dehydrogenase (NAD+) activity
TAM4_1111	COG1328	CTP reductase activity
TAM4_1115	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TAM4_112	COG0585	pseudouridine synthase activity
TAM4_1123	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TAM4_1125	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TAM4_1126	COG0444	Belongs to the ABC transporter superfamily
TAM4_1127	COG0714	Associated with various cellular activities
TAM4_113	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TAM4_1130	COG0437	4 iron, 4 sulfur cluster binding
TAM4_1133	COG0309	Hydrogenase expression formation protein (HypE)
TAM4_1134	COG3260	NADH ubiquinone oxidoreductase 20
TAM4_1135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TAM4_1136	COG1373	ATPase (AAA superfamily
TAM4_1138	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TAM4_1139	COG0650	Formate hydrogenlyase subunit 4
TAM4_114	COG0543	2 iron, 2 sulfur cluster binding
TAM4_1140	COG0601	transmembrane transport
TAM4_1143	COG3261	NADH dehydrogenase
TAM4_1143	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
TAM4_1145	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TAM4_1147	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TAM4_1149	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TAM4_1151	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TAM4_1155	COG1126	abc transporter atp-binding protein
TAM4_1157	COG1269	ATP hydrolysis coupled proton transport
TAM4_1158	COG3260	NADH ubiquinone oxidoreductase 20
TAM4_1159	COG1115	amino acid carrier protein
TAM4_1160	COG0402	S-adenosylhomocysteine deaminase activity
TAM4_1161	COG0298	carbon dioxide binding
TAM4_1166	COG2255	four-way junction helicase activity
TAM4_1169	COG0095	Lipoate-protein ligase
TAM4_1172	COG1122	ATPase activity
TAM4_1173	COG3261	NADH dehydrogenase
TAM4_1173	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
TAM4_1177	COG0651	ATP synthesis coupled electron transport
TAM4_1178	COG0180	Tryptophanyl-tRNA synthetase
TAM4_118	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TAM4_1188	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TAM4_1192	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TAM4_1195	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TAM4_1196	COG1309	transcriptional regulator
TAM4_1197	COG0148	phosphopyruvate hydratase activity
TAM4_120	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TAM4_1200	COG0167	dihydroorotate dehydrogenase activity
TAM4_1210	COG1980	fructose-bisphosphate aldolase activity
TAM4_1214	COG0314	molybdopterin synthase activity
TAM4_1218	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TAM4_1219	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TAM4_122	COG2813	Specifically methylates the guanine in position
TAM4_1225	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TAM4_1228	COG1047	Peptidyl-prolyl cis-trans
TAM4_1230	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TAM4_1231	COG1254	Belongs to the acylphosphatase family
TAM4_1233	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TAM4_1236	COG2095	MarC family integral membrane protein
TAM4_1237	COG0765	amino acid transport
TAM4_1239	COG2111	Na H antiporter
TAM4_1239	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TAM4_1240	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TAM4_1241	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TAM4_1244	COG0489	protein tyrosine kinase activity
TAM4_1246	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
TAM4_1247	COG0543	2 iron, 2 sulfur cluster binding
TAM4_1248	COG1160	GTP binding
TAM4_1253	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
TAM4_1259	COG1522	sequence-specific DNA binding
TAM4_1264	COG0306	phosphate transporter
TAM4_1269	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TAM4_127	COG1522	sequence-specific DNA binding
TAM4_1272	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TAM4_1275	COG0650	Formate hydrogenlyase subunit 4
TAM4_1276	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TAM4_1277	COG0492	ferredoxin-NADP+ reductase activity
TAM4_1279	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TAM4_1286	COG0037	tRNA processing
TAM4_1295	COG0640	Transcriptional regulator
TAM4_13	COG1192	Involved in chromosome partitioning
TAM4_1308	COG0475	glutathione-regulated potassium exporter activity
TAM4_1322	COG0116	Belongs to the methyltransferase superfamily
TAM4_1328	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
TAM4_1329	COG0235	Class ii aldolase
TAM4_133	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TAM4_1330	COG2022	thiamine diphosphate biosynthetic process
TAM4_1331	COG0409	Hydrogenase expression formation protein
TAM4_1335	COG0674	pyruvate-flavodoxin oxidoreductase activity
TAM4_1338	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TAM4_1339	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TAM4_134	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TAM4_1342	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
TAM4_1346	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TAM4_1346	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TAM4_1348	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TAM4_135	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TAM4_1351	COG1628	Protein of unknown function DUF99
TAM4_1362	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TAM4_1364	COG0482	sulfurtransferase activity
TAM4_1367	COG2515	1-aminocyclopropane-1-carboxylate deaminase
TAM4_1368	COG0589	response to stress
TAM4_1369	COG0601	transmembrane transport
TAM4_137	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TAM4_1382	COG0517	IMP dehydrogenase activity
TAM4_1382	COG0516	GMP reductase activity
TAM4_1384	COG1320	monovalent cation:proton antiporter activity
TAM4_1385	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TAM4_1386	COG1013	pyruvate-flavodoxin oxidoreductase activity
TAM4_1387	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TAM4_1389	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TAM4_1390	COG0174	glutamine synthetase
TAM4_1391	COG0746	molybdenum cofactor guanylyltransferase activity
TAM4_1396	COG0864	Transcriptional regulator
TAM4_1398	COG1013	pyruvate-flavodoxin oxidoreductase activity
TAM4_1399	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
TAM4_1401	COG0489	protein tyrosine kinase activity
TAM4_1411	COG2814	Major facilitator Superfamily
TAM4_1412	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TAM4_1419	COG0651	ATP synthesis coupled electron transport
TAM4_1422	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TAM4_1422	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TAM4_1436	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TAM4_1444	COG0179	Fumarylacetoacetate (FAA) hydrolase
TAM4_1446	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TAM4_1449	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TAM4_1449	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TAM4_1450	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TAM4_1451	COG0475	glutathione-regulated potassium exporter activity
TAM4_1452	COG4608	Belongs to the ABC transporter superfamily
TAM4_1454	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TAM4_1457	COG0823	Involved in the tonB-independent uptake of proteins
TAM4_1457	COG1506	peptidase
TAM4_1457	COG4946	Tricorn protease homolog
TAM4_1459	COG0116	Belongs to the methyltransferase superfamily
TAM4_1460	COG0674	pyruvate-flavodoxin oxidoreductase activity
TAM4_1473	COG0252	asparaginase activity
TAM4_1476	COG1446	asparaginase
TAM4_1482	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TAM4_1486	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TAM4_1487	COG0215	cysteine-tRNA ligase activity
TAM4_1494	COG2205	protein histidine kinase activity
TAM4_1498	COG0058	SHG alpha-glucan phosphorylase activity
TAM4_15	COG1449	Belongs to the glycosyl hydrolase 57 family
TAM4_1500	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TAM4_1501	COG2002	toxin-antitoxin pair type II binding
TAM4_1503	COG0463	Glycosyl transferase, family 2
TAM4_1505	COG4208	sulfate ABC transporter
TAM4_1506	COG1979	alcohol dehydrogenase
TAM4_151	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TAM4_1512	COG2201	protein-glutamate methylesterase activity
TAM4_1514	COG0049	tRNA binding
TAM4_1516	COG1543	Belongs to the glycosyl hydrolase 57 family
TAM4_1525	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TAM4_1529	COG0301	tRNA thio-modification
TAM4_153	COG0495	leucyl-tRNA aminoacylation
TAM4_1533	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TAM4_1536	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TAM4_1541	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TAM4_1544	COG3842	ATPase activity
TAM4_1545	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TAM4_1547	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TAM4_1547	COG0517	IMP dehydrogenase activity
TAM4_1548	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TAM4_1548	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TAM4_1549	COG0546	phosphoglycolate phosphatase activity
TAM4_155	COG3885	ferrous iron binding
TAM4_155	COG2078	PFAM AMMECR1 domain protein
TAM4_1557	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TAM4_1561	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TAM4_1567	COG0419	ATPase involved in DNA repair
TAM4_1567	COG0419	ATPase involved in DNA repair
TAM4_1568	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TAM4_1569	COG1131	(ABC) transporter
TAM4_157	COG0009	L-threonylcarbamoyladenylate synthase
TAM4_1572	COG1469	GTP cyclohydrolase I activity
TAM4_1574	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TAM4_1578	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TAM4_1579	COG0556	nucleotide-excision repair
TAM4_158	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TAM4_1581	COG3473	Maleate cis-trans isomerase
TAM4_1582	COG0504	CTP synthase activity
TAM4_1587	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
TAM4_1587	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
TAM4_159	COG1373	ATPase (AAA superfamily
TAM4_1590	COG0733	neurotransmitter:sodium symporter activity
TAM4_1593	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TAM4_1594	COG2414	aldehyde ferredoxin oxidoreductase
TAM4_1600	COG2078	PFAM AMMECR1 domain protein
TAM4_1608	COG2271	Major facilitator Superfamily
TAM4_1614	COG0131	Imidazoleglycerol-phosphate dehydratase
TAM4_1620	COG0456	acetyltransferase
TAM4_1622	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TAM4_1624	COG1830	Aldolase
TAM4_163	COG2361	Protein of unknown function DUF86
TAM4_1633	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TAM4_1634	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TAM4_1635	COG3842	ATPase activity
TAM4_1637	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TAM4_1638	COG2815	serine threonine protein kinase
TAM4_1638	COG0515	serine threonine protein kinase
TAM4_164	COG1598	PFAM Uncharacterised protein family UPF0150
TAM4_165	COG1522	sequence-specific DNA binding
TAM4_1650	COG0071	Belongs to the small heat shock protein (HSP20) family
TAM4_1651	COG1185	polyribonucleotide nucleotidyltransferase activity
TAM4_1655	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TAM4_1655	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TAM4_1663	COG0521	Mo-molybdopterin cofactor biosynthetic process
TAM4_1664	COG1160	GTP binding
TAM4_1669	COG1136	(ABC) transporter
TAM4_1673	COG1110	DNA topoisomerase II activity
TAM4_1676	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TAM4_1684	COG2814	Major facilitator Superfamily
TAM4_169	COG0616	signal peptide processing
TAM4_1694	COG4149	molybdate abc transporter
TAM4_1697	COG1881	PFAM PEBP family protein
TAM4_17	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TAM4_1701	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TAM4_1708	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TAM4_1710	COG0107	imidazoleglycerol-phosphate synthase activity
TAM4_1715	COG1373	ATPase (AAA superfamily
TAM4_1716	COG1058	Belongs to the CinA family
TAM4_1716	COG1546	Belongs to the CinA family
TAM4_1722	COG0085	RNA polymerase activity
TAM4_1726	COG0301	tRNA thio-modification
TAM4_1729	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TAM4_1734	COG2264	protein methyltransferase activity
TAM4_1739	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TAM4_1743	COG1757	Na H antiporter
TAM4_1747	COG0417	DNA replication proofreading
TAM4_1755	COG2198	Histidine kinase
TAM4_1755	COG0643	Histidine kinase
TAM4_1757	COG0732	type I restriction modification DNA specificity domain
TAM4_1758	COG2211	Major facilitator Superfamily
TAM4_1763	COG1993	acr, cog1993
TAM4_1767	COG0303	'Molybdopterin
TAM4_1772	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TAM4_1773	COG0628	permease
TAM4_1774	COG1487	ribonuclease activity
TAM4_1775	COG0140	phosphoribosyl-ATP diphosphatase activity
TAM4_1775	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TAM4_1776	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TAM4_1778	COG0456	acetyltransferase
TAM4_178	COG2414	aldehyde ferredoxin oxidoreductase
TAM4_1786	COG2271	Major facilitator Superfamily
TAM4_179	COG0463	Glycosyl transferase, family 2
TAM4_179	COG1216	Glycosyl transferase, family 2
TAM4_1790	COG0423	glycine-tRNA ligase activity
TAM4_1791	COG0725	ABC transporter, periplasmic molybdate-binding protein
TAM4_1793	COG0584	glycerophosphoryl diester phosphodiesterase
TAM4_1794	COG1872	DUF167
TAM4_1795	COG0714	Associated with various cellular activities
TAM4_1796	COG1301	dicarboxylic acid transport
TAM4_1798	COG1131	(ABC) transporter
TAM4_1800	COG0483	inositol monophosphate 1-phosphatase activity
TAM4_1803	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TAM4_1805	COG0475	glutathione-regulated potassium exporter activity
TAM4_1813	COG1201	RNA secondary structure unwinding
TAM4_1814	COG1695	Transcriptional regulator
TAM4_1816	COG0011	TIGRFAM Protein of
TAM4_1819	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
TAM4_1822	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TAM4_1825	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TAM4_1826	COG0312	modulator of DNA gyrase
TAM4_1833	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TAM4_1833	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TAM4_1834	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TAM4_1835	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TAM4_1838	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TAM4_1842	COG0359	binds to the 23S rRNA
TAM4_1842	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
TAM4_1845	COG1355	regulation of microtubule-based process
TAM4_1848	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TAM4_1850	COG4143	(ABC) transporter
TAM4_1857	COG1196	nuclear chromosome segregation
TAM4_1859	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TAM4_1861	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TAM4_1864	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TAM4_1866	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TAM4_1872	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TAM4_1873	COG1129	ABC transporter
TAM4_188	COG0540	Belongs to the ATCase OTCase family
TAM4_1880	COG0019	diaminopimelate decarboxylase activity
TAM4_1882	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TAM4_1882	COG0674	pyruvate-flavodoxin oxidoreductase activity
TAM4_1883	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TAM4_1885	COG1078	dGTPase activity
TAM4_1887	COG0084	hydrolase, TatD family'
TAM4_1892	COG2033	superoxide reductase activity
TAM4_1895	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TAM4_1903	COG1518	maintenance of DNA repeat elements
TAM4_1909	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TAM4_1909	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TAM4_1917	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TAM4_1920	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TAM4_1922	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TAM4_1926	COG1794	racemase activity, acting on amino acids and derivatives
TAM4_193	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TAM4_1930	COG2096	Adenosyltransferase
TAM4_1931	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TAM4_1934	COG0482	sulfurtransferase activity
TAM4_1935	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TAM4_1936	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TAM4_1941	COG1013	pyruvate-flavodoxin oxidoreductase activity
TAM4_1942	COG0307	riboflavin synthase, alpha
TAM4_1943	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TAM4_1945	COG1063	alcohol dehydrogenase
TAM4_1947	COG2894	cell division
TAM4_1948	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TAM4_195	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TAM4_1954	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TAM4_1955	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TAM4_1957	COG0651	ATP synthesis coupled electron transport
TAM4_1958	COG3842	ATPase activity
TAM4_1967	COG0045	succinate-CoA ligase (ADP-forming) activity
TAM4_1967	COG1042	CoA-binding domain protein
TAM4_1967	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TAM4_1977	COG1320	monovalent cation:proton antiporter activity
TAM4_1983	COG1528	Iron-storage protein
TAM4_1985	COG1984	allophanate hydrolase subunit 2
TAM4_1988	COG0126	phosphoglycerate kinase activity
TAM4_199	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TAM4_1992	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TAM4_1993	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TAM4_20	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TAM4_2005	COG0436	Aminotransferase
TAM4_2010	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TAM4_2014	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TAM4_2017	COG2226	methyltransferase
TAM4_2019	COG1739	Uncharacterized protein family UPF0029
TAM4_2021	COG1078	dGTPase activity
TAM4_2024	COG1473	amidohydrolase
TAM4_2025	COG0163	prenyltransferase activity
TAM4_2028	COG2247	cell wall binding repeat
TAM4_2028	COG0860	N-Acetylmuramoyl-L-alanine amidase
TAM4_2029	COG1863	multisubunit Na H antiporter MnhE subunit
TAM4_203	COG0017	Asparaginyl-tRNA synthetase
TAM4_2030	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
TAM4_2039	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TAM4_204	COG0148	phosphopyruvate hydratase activity
TAM4_2042	COG1773	rubredoxin
TAM4_2044	COG1592	Rubrerythrin
TAM4_205	COG0456	acetyltransferase
TAM4_2050	COG1116	anion transmembrane transporter activity
TAM4_2055	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TAM4_2055	COG2050	protein possibly involved in aromatic compounds catabolism
TAM4_2056	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TAM4_2057	COG1794	racemase activity, acting on amino acids and derivatives
TAM4_206	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TAM4_2062	COG0668	transmembrane transport
TAM4_2063	COG1121	(ABC) transporter
TAM4_2070	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TAM4_2072	COG0602	queuosine metabolic process
TAM4_2078	COG1476	TRANSCRIPTIONal
TAM4_208	COG0089	rRNA binding
TAM4_2081	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TAM4_2081	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TAM4_2085	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TAM4_2089	COG1131	(ABC) transporter
TAM4_2092	COG1234	tRNA 3'-trailer cleavage
TAM4_2094	COG0006	proline dipeptidase activity
TAM4_2096	COG0450	alkyl hydroperoxide reductase
TAM4_2097	COG1444	tRNA N-acetyltransferase activity
TAM4_2101	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TAM4_2101	COG1918	ferrous iron import across plasma membrane
TAM4_2106	COG2409	Drug exporters of the RND superfamily
TAM4_2108	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TAM4_2118	COG1178	ABC-type Fe3 transport system permease component
TAM4_2122	COG1487	ribonuclease activity
TAM4_2126	COG0631	protein serine/threonine phosphatase activity
TAM4_2128	COG0426	domain, Protein
TAM4_2130	COG0513	Belongs to the DEAD box helicase family
TAM4_2138	COG1522	sequence-specific DNA binding
TAM4_214	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
TAM4_2143	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TAM4_2149	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
TAM4_215	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TAM4_2151	COG1215	transferase activity, transferring glycosyl groups
TAM4_2152	COG0006	proline dipeptidase activity
TAM4_2153	COG0306	phosphate transporter
TAM4_2157	COG1006	Multisubunit Na H antiporter MnhC subunit
TAM4_2160	COG0674	pyruvate-flavodoxin oxidoreductase activity
TAM4_2160	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TAM4_2164	COG0778	Nitroreductase
TAM4_217	COG0284	orotidine-5'-phosphate decarboxylase activity
TAM4_2178	COG0142	geranyltranstransferase activity
TAM4_218	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TAM4_2186	COG1294	oxidase, subunit
TAM4_2188	COG1013	pyruvate-flavodoxin oxidoreductase activity
TAM4_2191	COG1122	ATPase activity
TAM4_2194	COG0720	synthase
TAM4_2197	COG0446	pyridine nucleotide-disulphide oxidoreductase
TAM4_2199	COG0243	molybdopterin cofactor binding
TAM4_221	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TAM4_2210	COG1363	Peptidase, m42
TAM4_2212	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TAM4_2213	COG0735	belongs to the Fur family
TAM4_222	COG2894	cell division
TAM4_223	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TAM4_226	COG1304	FMN binding
TAM4_2323	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TAM4_2325	COG0011	TIGRFAM Protein of
TAM4_2327	COG2815	serine threonine protein kinase
TAM4_2327	COG0515	serine threonine protein kinase
TAM4_2331	COG2815	serine threonine protein kinase
TAM4_2331	COG0515	serine threonine protein kinase
TAM4_2334	COG2815	serine threonine protein kinase
TAM4_2334	COG0515	serine threonine protein kinase
TAM4_2346	COG2131	deaminase
TAM4_2347	COG2140	Oxalate decarboxylase
TAM4_2348	COG1994	Peptidase M50
TAM4_2355	COG1335	isochorismatase
TAM4_2357	COG1056	cytidyltransferase-related domain
TAM4_2357	COG1051	belongs to the nudix hydrolase family
TAM4_236	COG2119	membrane
TAM4_2371	COG0482	sulfurtransferase activity
TAM4_2383	COG1136	(ABC) transporter
TAM4_2387	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
TAM4_2425	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
TAM4_2433	COG1216	Glycosyl transferase, family 2
TAM4_244	COG0088	Forms part of the polypeptide exit tunnel
TAM4_2446	COG0306	phosphate transporter
TAM4_245	COG4956	integral membrane protein (PIN domain superfamily)
TAM4_2460	COG0543	2 iron, 2 sulfur cluster binding
TAM4_247	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TAM4_2470	COG1342	Belongs to the UPF0251 family
TAM4_2471	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
TAM4_2472	COG4608	Belongs to the ABC transporter superfamily
TAM4_250	COG0303	'Molybdopterin
TAM4_251	COG1185	polyribonucleotide nucleotidyltransferase activity
TAM4_252	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TAM4_254	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TAM4_256	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TAM4_258	COG1418	mRNA catabolic process
TAM4_260	COG0434	BtpA family
TAM4_261	COG0517	IMP dehydrogenase activity
TAM4_261	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TAM4_263	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TAM4_270	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
TAM4_272	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TAM4_273	COG0006	proline dipeptidase activity
TAM4_275	COG1525	nuclease
TAM4_277	COG0023	Translation Initiation Factor
TAM4_28	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TAM4_285	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TAM4_288	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
TAM4_289	COG0017	Asparaginyl-tRNA synthetase
TAM4_293	COG0037	tRNA processing
TAM4_294	COG2255	four-way junction helicase activity
TAM4_3	COG1346	cytolysis
TAM4_302	COG0475	glutathione-regulated potassium exporter activity
TAM4_303	COG0105	UTP biosynthetic process
TAM4_306	COG2226	methyltransferase
TAM4_308	COG1091	dTDP-4-dehydrorhamnose reductase activity
TAM4_312	COG0367	asparagine synthase
TAM4_313	COG0463	Glycosyl transferase, family 2
TAM4_318	COG0142	geranyltranstransferase activity
TAM4_319	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TAM4_32	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TAM4_321	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TAM4_323	COG1372	Participates in initiation and elongation during chromosome replication
TAM4_323	COG0305	Participates in initiation and elongation during chromosome replication
TAM4_327	COG1120	ATPase activity
TAM4_33	COG0511	ligase activity, forming carbon-carbon bonds
TAM4_33	COG5016	pyruvate
TAM4_335	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TAM4_339	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TAM4_340	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TAM4_347	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TAM4_348	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TAM4_356	COG1121	(ABC) transporter
TAM4_358	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TAM4_364	COG0255	Belongs to the universal ribosomal protein uL29 family
TAM4_365	COG0156	8-amino-7-oxononanoate synthase activity
TAM4_366	COG1102	Psort location Cytoplasmic, score
TAM4_367	COG0200	Binds to the 23S rRNA
TAM4_369	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TAM4_370	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TAM4_376	COG4221	oxidoreductase activity
TAM4_378	COG0460	homoserine dehydrogenase
TAM4_384	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TAM4_390	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TAM4_391	COG2894	cell division
TAM4_40	COG0312	modulator of DNA gyrase
TAM4_416	COG0693	protein deglycase activity
TAM4_420	COG0501	Belongs to the peptidase M48B family
TAM4_423	COG0546	phosphoglycolate phosphatase activity
TAM4_424	COG0436	Aminotransferase
TAM4_429	COG1515	deoxyribonuclease V activity
TAM4_43	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TAM4_433	COG0252	asparaginase activity
TAM4_434	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TAM4_435	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TAM4_436	COG0459	protein refolding
TAM4_437	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TAM4_44	COG2226	methyltransferase
TAM4_441	COG0501	Belongs to the peptidase M48B family
TAM4_442	COG4608	Belongs to the ABC transporter superfamily
TAM4_445	COG0519	Catalyzes the synthesis of GMP from XMP
TAM4_445	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TAM4_448	COG1373	ATPase (AAA superfamily
TAM4_456	COG2264	protein methyltransferase activity
TAM4_463	COG0543	2 iron, 2 sulfur cluster binding
TAM4_466	COG0183	Belongs to the thiolase family
TAM4_467	COG0038	chloride channel
TAM4_469	COG0123	including yeast histone deacetylase and acetoin utilization protein
TAM4_473	COG0330	HflC and HflK could
TAM4_474	COG1863	multisubunit Na H antiporter MnhE subunit
TAM4_475	COG0366	Alpha amylase catalytic
TAM4_477	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TAM4_477	COG2111	Na H antiporter
TAM4_484	COG0018	arginyl-trna synthetase
TAM4_485	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TAM4_489	COG0649	NAD binding
TAM4_492	COG1234	tRNA 3'-trailer cleavage
TAM4_493	COG0517	IMP dehydrogenase activity
TAM4_493	COG0516	GMP reductase activity
TAM4_499	COG2815	serine threonine protein kinase
TAM4_499	COG0515	serine threonine protein kinase
TAM4_5	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TAM4_5	COG1213	nucleotidyl transferase
TAM4_501	COG2379	hydroxypyruvate reductase
TAM4_505	COG0438	transferase activity, transferring glycosyl groups
TAM4_506	COG0175	sulfate reduction
TAM4_510	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TAM4_517	COG0561	phosphatase activity
TAM4_521	COG0730	response to heat
TAM4_526	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TAM4_532	COG0534	Mate efflux family protein
TAM4_534	COG0746	molybdenum cofactor guanylyltransferase activity
TAM4_536	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TAM4_537	COG1028	Short-chain dehydrogenase reductase Sdr
TAM4_54	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TAM4_544	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TAM4_548	COG0010	Belongs to the arginase family
TAM4_549	COG1694	Mazg nucleotide pyrophosphohydrolase
TAM4_55	COG0052	Belongs to the universal ribosomal protein uS2 family
TAM4_553	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
TAM4_556	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TAM4_56	COG1573	uracil-dna glycosylase
TAM4_561	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TAM4_57	COG0424	maF-like protein
TAM4_571	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TAM4_572	COG0444	Belongs to the ABC transporter superfamily
TAM4_574	COG0719	Fe-S assembly protein
TAM4_576	COG0442	prolyl-tRNA aminoacylation
TAM4_578	COG0310	cobalt ion transport
TAM4_582	COG1151	hydroxylamine reductase activity
TAM4_583	COG0045	succinate-CoA ligase (ADP-forming) activity
TAM4_583	COG1042	CoA-binding domain protein
TAM4_583	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TAM4_591	COG0315	cyclic pyranopterin monophosphate synthase activity
TAM4_592	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TAM4_594	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TAM4_594	COG0493	'glutamate synthase
TAM4_598	COG2264	protein methyltransferase activity
TAM4_6	COG0430	RNA-3'-phosphate cyclase activity
TAM4_600	COG3842	ATPase activity
TAM4_601	COG2002	toxin-antitoxin pair type II binding
TAM4_608	COG0493	'glutamate synthase
TAM4_61	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TAM4_610	COG3383	formate dehydrogenase (NAD+) activity
TAM4_611	COG1505	serine-type exopeptidase activity
TAM4_614	COG1122	ATPase activity
TAM4_616	COG0297	glycogen (starch) synthase activity
TAM4_621	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TAM4_626	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TAM4_63	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TAM4_630	COG2267	carboxylic ester hydrolase activity
TAM4_632	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TAM4_634	COG0402	S-adenosylhomocysteine deaminase activity
TAM4_635	COG0823	Involved in the tonB-independent uptake of proteins
TAM4_635	COG1506	peptidase
TAM4_635	COG4946	Tricorn protease homolog
TAM4_637	COG1476	TRANSCRIPTIONal
TAM4_640	COG0310	cobalt ion transport
TAM4_646	COG0393	Putative heavy-metal-binding
TAM4_648	COG1141	Ferredoxin
TAM4_660	COG1899	peptidyl-lysine modification to peptidyl-hypusine
TAM4_662	COG0747	negative chemotaxis
TAM4_665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TAM4_666	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TAM4_668	COG2264	protein methyltransferase activity
TAM4_669	COG0515	serine threonine protein kinase
TAM4_679	COG2234	aminopeptidase activity
TAM4_681	COG0651	ATP synthesis coupled electron transport
TAM4_683	COG1492	cobalamin metabolic process
TAM4_685	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TAM4_688	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TAM4_691	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TAM4_696	COG3842	ATPase activity
TAM4_697	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TAM4_701	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
TAM4_704	COG0560	Phosphoserine phosphatase
TAM4_706	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TAM4_707	COG0631	protein serine/threonine phosphatase activity
TAM4_712	COG1111	helicase
TAM4_712	COG1205	dead DEAH box helicase
TAM4_713	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TAM4_716	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TAM4_719	COG0437	4 iron, 4 sulfur cluster binding
TAM4_720	COG2815	serine threonine protein kinase
TAM4_720	COG0515	serine threonine protein kinase
TAM4_721	COG0012	GTP binding
TAM4_722	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TAM4_729	COG0730	response to heat
TAM4_735	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TAM4_742	COG0717	Belongs to the dCTP deaminase family
TAM4_745	COG0534	Mate efflux family protein
TAM4_753	COG0017	Asparaginyl-tRNA synthetase
TAM4_756	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TAM4_759	COG1404	Belongs to the peptidase S8 family
TAM4_763	COG1695	Transcriptional regulator
TAM4_766	COG0437	4 iron, 4 sulfur cluster binding
TAM4_769	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TAM4_771	COG1378	Sugar-specific transcriptional regulator TrmB
TAM4_772	COG1435	thymidine kinase activity
TAM4_774	COG0151	Belongs to the GarS family
TAM4_776	COG0432	Pfam Uncharacterised protein family UPF0047
TAM4_778	COG1178	ABC-type Fe3 transport system permease component
TAM4_784	COG4166	transmembrane transport
TAM4_786	COG1120	ATPase activity
TAM4_79	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TAM4_790	COG0157	Belongs to the NadC ModD family
TAM4_791	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TAM4_795	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TAM4_8	COG0513	Belongs to the DEAD box helicase family
TAM4_801	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TAM4_803	COG1851	Uncharacterised protein family (UPF0128)
TAM4_807	COG1832	CoA-binding protein
TAM4_816	COG1175	transmembrane transport
TAM4_818	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TAM4_819	COG1215	transferase activity, transferring glycosyl groups
TAM4_824	COG2252	PERMEase
TAM4_826	COG0312	modulator of DNA gyrase
TAM4_827	COG1765	OsmC-like protein
TAM4_83	COG0579	oxidoreductase
TAM4_835	COG0509	glycine decarboxylation via glycine cleavage system
TAM4_836	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TAM4_843	COG2095	MarC family integral membrane protein
TAM4_847	COG0455	bacterial-type flagellum organization
TAM4_85	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TAM4_852	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TAM4_853	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TAM4_859	COG0493	'glutamate synthase
TAM4_859	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TAM4_860	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TAM4_862	COG0051	transcription antitermination factor activity, RNA binding
TAM4_864	COG1320	monovalent cation:proton antiporter activity
TAM4_867	COG1522	sequence-specific DNA binding
TAM4_869	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TAM4_872	COG1193	negative regulation of DNA recombination
TAM4_878	COG0517	IMP dehydrogenase activity
TAM4_878	COG0516	GMP reductase activity
TAM4_879	COG0534	Mate efflux family protein
TAM4_882	COG2403	cyclic 2,3-diphosphoglycerate synthetase activity
TAM4_885	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TAM4_888	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TAM4_893	COG1185	polyribonucleotide nucleotidyltransferase activity
TAM4_9	COG0330	HflC and HflK could
TAM4_902	COG2723	6-phospho-beta-galactosidase activity
TAM4_903	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TAM4_909	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TAM4_911	COG2342	PFAM TM1410 hypothetical-related protein
TAM4_912	COG0668	transmembrane transport
TAM4_918	COG1006	Multisubunit Na H antiporter MnhC subunit
TAM4_920	COG0396	ATPase activity
TAM4_923	COG0525	valine-tRNA ligase activity
TAM4_925	COG1522	sequence-specific DNA binding
TAM4_928	COG0574	Belongs to the PEP-utilizing enzyme family
TAM4_928	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TAM4_93	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TAM4_930	COG2212	antiporter activity
TAM4_934	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TAM4_935	COG0489	protein tyrosine kinase activity
TAM4_937	COG1489	DNA binding
TAM4_938	COG0731	radical SAM domain protein
TAM4_938	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TAM4_943	COG0444	Belongs to the ABC transporter superfamily
TAM4_947	COG0515	serine threonine protein kinase
TAM4_947	COG2815	serine threonine protein kinase
TAM4_949	COG0081	regulation of translation
TAM4_95	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TAM4_956	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TAM4_956	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TAM4_959	COG2815	serine threonine protein kinase
TAM4_959	COG0515	serine threonine protein kinase
TAM4_960	COG0601	transmembrane transport
TAM4_963	COG0428	transporter
TAM4_972	COG1201	RNA secondary structure unwinding
TAM4_972	COG1201	RNA secondary structure unwinding
TAM4_973	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TAM4_975	COG0024	Methionine aminopeptidase
TAM4_976	COG0656	L-ascorbic acid biosynthetic process
TAM4_978	COG0047	phosphoribosylformylglycinamidine synthase activity
TAM4_981	COG1966	Carbon starvation protein
TAM4_983	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TAM4_984	COG0446	pyridine nucleotide-disulphide oxidoreductase
TAM4_986	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TAM4_987	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TAM4_990	COG2192	nodulation
TAM4_991	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TAM4_993	COG0519	Catalyzes the synthesis of GMP from XMP
TAM4_993	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TAM4_994	COG0517	IMP dehydrogenase activity
TAM4_994	COG0794	Belongs to the SIS family. GutQ KpsF subfamily