locus-tag	class	description
FH039_00005	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FH039_00015	COG0840	transmembrane signaling receptor activity
FH039_00025	COG1380	Effector of murein hydrolase LrgA
FH039_00030	COG1346	cytolysis
FH039_00060	COG0235	Class ii aldolase
FH039_00070	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
FH039_00100	COG0095	Lipoate-protein ligase
FH039_00105	COG0681	Belongs to the peptidase S26 family
FH039_00155	COG0823	Involved in the tonB-independent uptake of proteins
FH039_00155	COG1506	peptidase
FH039_00155	COG4946	Tricorn protease homolog
FH039_00185	COG1131	(ABC) transporter
FH039_00215	COG1122	ATPase activity
FH039_00230	COG0306	phosphate transporter
FH039_00260	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FH039_00270	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FH039_00280	COG2212	antiporter activity
FH039_00285	COG1320	monovalent cation:proton antiporter activity
FH039_00310	COG0651	ATP synthesis coupled electron transport
FH039_00320	COG3260	NADH ubiquinone oxidoreductase 20
FH039_00325	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FH039_00335	COG0650	Formate hydrogenlyase subunit 4
FH039_00340	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FH039_00350	COG2212	antiporter activity
FH039_00355	COG1320	monovalent cation:proton antiporter activity
FH039_00370	COG2111	Na H antiporter
FH039_00375	COG1006	Multisubunit Na H antiporter MnhC subunit
FH039_00380	COG0651	ATP synthesis coupled electron transport
FH039_00390	COG3260	NADH ubiquinone oxidoreductase 20
FH039_00395	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FH039_00445	COG2255	four-way junction helicase activity
FH039_00460	COG0492	ferredoxin-NADP+ reductase activity
FH039_00465	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FH039_00495	COG0148	phosphopyruvate hydratase activity
FH039_00510	COG1522	sequence-specific DNA binding
FH039_00515	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FH039_00535	COG0314	molybdopterin synthase activity
FH039_00545	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FH039_00600	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FH039_00610	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FH039_00705	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FH039_00710	COG0402	S-adenosylhomocysteine deaminase activity
FH039_00725	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
FH039_00725	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FH039_00740	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FH039_00740	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FH039_00780	COG0640	Transcriptional regulator
FH039_00785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FH039_00785	COG1042	CoA-binding domain protein
FH039_00785	COG0045	succinate-CoA ligase (ADP-forming) activity
FH039_00805	COG0179	Fumarylacetoacetate (FAA) hydrolase
FH039_00825	COG0116	Belongs to the methyltransferase superfamily
FH039_00845	COG1160	GTP binding
FH039_00890	COG1047	Peptidyl-prolyl cis-trans
FH039_00920	COG0714	Associated with various cellular activities
FH039_00960	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
FH039_00970	COG2442	InterPro IPR007367
FH039_00980	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FH039_00985	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
FH039_01025	COG0037	tRNA processing
FH039_01030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FH039_01040	COG0463	Glycosyl transferase, family 2
FH039_01050	COG1442	glycosyl transferase family 8
FH039_01050	COG1216	Glycosyl transferase, family 2
FH039_01060	COG2244	polysaccharide biosynthetic process
FH039_01065	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FH039_01070	COG0076	glutamate decarboxylase activity
FH039_01075	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FH039_01075	COG4651	solute:proton antiporter activity
FH039_01100	COG1449	Belongs to the glycosyl hydrolase 57 family
FH039_01110	COG0037	tRNA processing
FH039_01125	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
FH039_01130	COG0517	IMP dehydrogenase activity
FH039_01130	COG0516	GMP reductase activity
FH039_01135	COG0475	glutathione-regulated potassium exporter activity
FH039_01140	COG0475	glutathione-regulated potassium exporter activity
FH039_01165	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FH039_01180	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FH039_01280	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
FH039_01290	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
FH039_01300	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FH039_01305	COG0569	domain protein
FH039_01315	COG1269	ATP hydrolysis coupled proton transport
FH039_01325	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
FH039_01340	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
FH039_01345	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
FH039_01360	COG0840	transmembrane signaling receptor activity
FH039_01365	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FH039_01380	COG1606	tRNA processing
FH039_01395	COG0543	2 iron, 2 sulfur cluster binding
FH039_01410	COG0601	transmembrane transport
FH039_01415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FH039_01420	COG0444	Belongs to the ABC transporter superfamily
FH039_01425	COG4608	Belongs to the ABC transporter superfamily
FH039_01445	COG0174	glutamine synthetase
FH039_01485	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
FH039_01505	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FH039_01520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FH039_01530	COG1297	OPT oligopeptide transporter protein
FH039_01535	COG1234	tRNA 3'-trailer cleavage
FH039_01540	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FH039_01560	COG3833	ABC-type maltose transport systems, permease component
FH039_01565	COG1175	transmembrane transport
FH039_01580	COG1378	Sugar-specific transcriptional regulator TrmB
FH039_01640	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
FH039_01655	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FH039_01705	COG0714	Associated with various cellular activities
FH039_01720	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FH039_01735	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FH039_01750	COG2046	Belongs to the sulfate adenylyltransferase family
FH039_01780	COG0730	response to heat
FH039_01860	COG0438	transferase activity, transferring glycosyl groups
FH039_01865	COG0482	sulfurtransferase activity
FH039_01870	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FH039_01875	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FH039_01885	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FH039_02015	COG0516	GMP reductase activity
FH039_02015	COG0517	IMP dehydrogenase activity
FH039_02020	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FH039_02040	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FH039_02050	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
FH039_02055	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
FH039_02070	COG3383	formate dehydrogenase (NAD+) activity
FH039_02085	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FH039_02090	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FH039_02095	COG1201	RNA secondary structure unwinding
FH039_02115	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FH039_02120	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
FH039_02125	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FH039_02130	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FH039_02145	COG0151	Belongs to the GarS family
FH039_02170	COG0047	phosphoribosylformylglycinamidine synthase activity
FH039_02205	COG1131	(ABC) transporter
FH039_02225	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FH039_02235	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FH039_02235	COG0519	Catalyzes the synthesis of GMP from XMP
FH039_02250	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FH039_02250	COG0519	Catalyzes the synthesis of GMP from XMP
FH039_02315	COG2890	protein-(glutamine-N5) methyltransferase activity
FH039_02415	COG1178	ABC-type Fe3 transport system permease component
FH039_02440	COG0011	TIGRFAM Protein of
FH039_02445	COG2078	PFAM AMMECR1 domain protein
FH039_02450	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FH039_02450	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FH039_02515	COG1185	polyribonucleotide nucleotidyltransferase activity
FH039_02535	COG1695	Transcriptional regulator
FH039_02540	COG2050	protein possibly involved in aromatic compounds catabolism
FH039_02540	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
FH039_02555	COG1335	isochorismatase
FH039_02620	COG1185	polyribonucleotide nucleotidyltransferase activity
FH039_02625	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FH039_02660	COG0517	IMP dehydrogenase activity
FH039_02660	COG1125	glycine betaine transport
FH039_02670	COG0511	ligase activity, forming carbon-carbon bonds
FH039_02670	COG5016	pyruvate
FH039_02680	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FH039_02690	COG1372	Participates in initiation and elongation during chromosome replication
FH039_02690	COG0305	Participates in initiation and elongation during chromosome replication
FH039_02715	COG0430	RNA-3'-phosphate cyclase activity
FH039_02775	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
FH039_02785	COG0543	2 iron, 2 sulfur cluster binding
FH039_02810	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FH039_02815	COG0017	Asparaginyl-tRNA synthetase
FH039_02830	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FH039_02855	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FH039_02860	COG0088	Forms part of the polypeptide exit tunnel
FH039_02865	COG0089	rRNA binding
FH039_02870	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FH039_02875	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FH039_02885	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FH039_02890	COG0255	Belongs to the universal ribosomal protein uL29 family
FH039_02895	COG0023	Translation Initiation Factor
FH039_02905	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FH039_02910	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FH039_02915	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FH039_02925	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FH039_02935	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FH039_02940	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FH039_02955	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FH039_02960	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FH039_02965	COG1841	ribosomal large subunit assembly
FH039_02970	COG0200	Binds to the 23S rRNA
FH039_02995	COG1102	Psort location Cytoplasmic, score
FH039_03005	COG0300	oxidoreductase activity
FH039_03020	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FH039_03030	COG2813	Specifically methylates the guanine in position
FH039_03040	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FH039_03045	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FH039_03050	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FH039_03070	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FH039_03075	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FH039_03100	COG0052	Belongs to the universal ribosomal protein uS2 family
FH039_03140	COG1522	sequence-specific DNA binding
FH039_03150	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FH039_03160	COG1522	sequence-specific DNA binding
FH039_03165	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FH039_03195	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FH039_03200	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FH039_03220	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
FH039_03225	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FH039_03230	COG1355	regulation of microtubule-based process
FH039_03250	COG2361	Protein of unknown function DUF86
FH039_03255	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FH039_03260	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FH039_03260	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FH039_03275	COG0348	domain, Protein
FH039_03280	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
FH039_03285	COG2414	aldehyde ferredoxin oxidoreductase
FH039_03305	COG0142	geranyltranstransferase activity
FH039_03310	COG0477	Major facilitator Superfamily
FH039_03325	COG0495	leucyl-tRNA aminoacylation
FH039_03335	COG0006	proline dipeptidase activity
FH039_03380	COG0626	cystathionine gamma-synthase activity
FH039_03395	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FH039_03400	COG0527	aspartate kinase activity
FH039_03410	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FH039_03415	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
FH039_03435	COG0864	Transcriptional regulator
FH039_03450	COG1543	Belongs to the glycosyl hydrolase 57 family
FH039_03455	COG0347	Belongs to the P(II) protein family
FH039_03465	COG0733	neurotransmitter:sodium symporter activity
FH039_03470	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FH039_03485	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
FH039_03490	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FH039_03505	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FH039_03545	COG0109	protoheme IX farnesyltransferase activity
FH039_03555	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FH039_03560	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FH039_03585	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FH039_03630	COG0668	transmembrane transport
FH039_03635	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FH039_03635	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FH039_03645	COG2264	protein methyltransferase activity
FH039_03660	COG0393	Putative heavy-metal-binding
FH039_03715	COG2234	aminopeptidase activity
FH039_03725	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
FH039_03730	COG0463	Glycosyl transferase, family 2
FH039_03745	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FH039_03750	COG0534	Mate efflux family protein
FH039_03760	COG0534	Mate efflux family protein
FH039_03765	COG0574	Belongs to the PEP-utilizing enzyme family
FH039_03765	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FH039_03790	COG1404	Belongs to the peptidase S8 family
FH039_03820	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FH039_03820	COG0731	radical SAM domain protein
FH039_03850	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FH039_03875	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
FH039_03880	COG0409	Hydrogenase expression formation protein
FH039_03885	COG0298	carbon dioxide binding
FH039_03905	COG0489	protein tyrosine kinase activity
FH039_03945	COG1234	tRNA 3'-trailer cleavage
FH039_03965	COG2140	Oxalate decarboxylase
FH039_03975	COG0662	Cupin 2, conserved barrel domain protein
FH039_03975	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
FH039_03995	COG1122	ATPase activity
FH039_04010	COG0310	cobalt ion transport
FH039_04025	COG1185	polyribonucleotide nucleotidyltransferase activity
FH039_04055	COG0436	Aminotransferase
FH039_04090	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FH039_04105	COG1487	ribonuclease activity
FH039_04115	COG0049	tRNA binding
FH039_04135	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FH039_04140	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FH039_04145	COG0085	RNA polymerase activity
FH039_04175	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FH039_04180	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FH039_04225	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FH039_04240	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FH039_04245	COG0081	regulation of translation
FH039_04265	COG0717	Belongs to the dCTP deaminase family
FH039_04290	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FH039_04300	COG0058	SHG alpha-glucan phosphorylase activity
FH039_04305	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
FH039_04320	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FH039_04340	COG2814	Major facilitator Superfamily
FH039_04350	COG0584	glycerophosphoryl diester phosphodiesterase
FH039_04360	COG0579	oxidoreductase
FH039_04435	COG0585	pseudouridine synthase activity
FH039_04445	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FH039_04460	COG0017	Asparaginyl-tRNA synthetase
FH039_04520	COG1418	mRNA catabolic process
FH039_04545	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
FH039_04595	COG1110	DNA topoisomerase II activity
FH039_04615	COG1042	CoA-binding domain protein
FH039_04615	COG0045	succinate-CoA ligase (ADP-forming) activity
FH039_04615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FH039_04665	COG1518	maintenance of DNA repeat elements
FH039_04675	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
FH039_04700	COG0644	oxidoreductase
FH039_04710	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FH039_04735	COG0504	CTP synthase activity
FH039_04755	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FH039_04770	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FH039_04780	COG0517	IMP dehydrogenase activity
FH039_04780	COG0516	GMP reductase activity
FH039_04790	COG0024	Methionine aminopeptidase
FH039_04795	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FH039_04800	COG1122	ATPase activity
FH039_04835	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FH039_04850	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FH039_04945	COG0628	permease
FH039_04950	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FH039_04995	COG1131	(ABC) transporter
FH039_05005	COG0556	nucleotide-excision repair
FH039_05010	COG0101	tRNA pseudouridine synthase activity
FH039_05020	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FH039_05025	COG1063	alcohol dehydrogenase
FH039_05030	COG2894	cell division
FH039_05050	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FH039_05055	COG0252	asparaginase activity
FH039_05125	COG0438	transferase activity, transferring glycosyl groups
FH039_05135	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FH039_05145	COG0038	chloride channel
FH039_05175	COG0010	Belongs to the arginase family
FH039_05220	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FH039_05245	COG1757	Na H antiporter
FH039_05260	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
FH039_05290	COG0656	L-ascorbic acid biosynthetic process
FH039_05330	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FH039_05330	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FH039_05345	COG0359	binds to the 23S rRNA
FH039_05345	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
FH039_05380	COG0573	inorganic phosphate transmembrane transporter activity
FH039_05390	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FH039_05400	COG0704	Plays a role in the regulation of phosphate uptake
FH039_05450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FH039_05485	COG1881	PFAM PEBP family protein
FH039_05530	COG1151	hydroxylamine reductase activity
FH039_05605	COG1522	sequence-specific DNA binding
FH039_05635	COG0649	NAD binding
FH039_05640	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FH039_05645	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FH039_05655	COG0651	ATP synthesis coupled electron transport
FH039_05660	COG0651	ATP synthesis coupled electron transport
FH039_05665	COG1006	Multisubunit Na H antiporter MnhC subunit
FH039_05670	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FH039_05670	COG2111	Na H antiporter
FH039_05680	COG1320	monovalent cation:proton antiporter activity
FH039_05685	COG2212	antiporter activity
FH039_05690	COG1863	multisubunit Na H antiporter MnhE subunit
FH039_05700	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FH039_05735	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FH039_05765	COG0018	arginyl-trna synthetase
FH039_05775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FH039_05900	COG0301	tRNA thio-modification
FH039_05900	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FH039_05905	COG1836	PFAM Integral membrane protein DUF92
FH039_05910	COG1522	sequence-specific DNA binding
FH039_05915	COG1694	Mazg nucleotide pyrophosphohydrolase
FH039_05945	COG0396	ATPase activity
FH039_05950	COG0719	Fe-S assembly protein
FH039_05975	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
FH039_05990	COG0243	molybdopterin cofactor binding
FH039_05995	COG0437	4 iron, 4 sulfur cluster binding
FH039_06010	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FH039_06015	COG3261	NADH dehydrogenase
FH039_06015	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
FH039_06020	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FH039_06055	COG1006	Multisubunit Na H antiporter MnhC subunit
FH039_06065	COG0651	ATP synthesis coupled electron transport
FH039_06080	COG0437	4 iron, 4 sulfur cluster binding
FH039_06095	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
FH039_06110	COG1476	TRANSCRIPTIONal
FH039_06145	COG1515	deoxyribonuclease V activity
FH039_06155	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
FH039_06175	COG0436	Aminotransferase
FH039_06190	COG2192	nodulation
FH039_06200	COG0442	prolyl-tRNA aminoacylation
FH039_06205	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FH039_06215	COG0730	response to heat
FH039_06220	COG0730	response to heat
FH039_06250	COG0720	synthase
FH039_06275	COG1013	pyruvate-flavodoxin oxidoreductase activity
FH039_06280	COG0674	pyruvate-flavodoxin oxidoreductase activity
FH039_06280	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FH039_06290	COG1895	HEPN domain
FH039_06300	COG1013	pyruvate-flavodoxin oxidoreductase activity
FH039_06305	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FH039_06305	COG0674	pyruvate-flavodoxin oxidoreductase activity
FH039_06330	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FH039_06380	COG1744	ABC transporter substrate-binding protein PnrA-like
FH039_06420	COG0215	cysteine-tRNA ligase activity
FH039_06425	COG1047	Peptidyl-prolyl cis-trans
FH039_06455	COG1992	Thiamine-phosphate synthase
FH039_06455	COG0351	phosphomethylpyrimidine kinase
FH039_06460	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
FH039_06470	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FH039_06490	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FH039_06500	COG1505	serine-type exopeptidase activity
FH039_06515	COG2267	carboxylic ester hydrolase activity
FH039_06540	COG0003	Pfam Anion-transporting ATPase
FH039_06550	COG1966	Carbon starvation protein
FH039_06560	COG1830	Aldolase
FH039_06580	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FH039_06640	COG1337	RAMP superfamily
FH039_06650	COG1353	crispr-associated protein
FH039_06700	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FH039_06720	COG0735	belongs to the Fur family
FH039_06760	COG2033	superoxide reductase activity
FH039_06765	COG1773	rubredoxin
FH039_06770	COG1592	Rubrerythrin
FH039_06775	COG0446	pyridine nucleotide-disulphide oxidoreductase
FH039_06780	COG0426	domain, Protein
FH039_06785	COG0450	alkyl hydroperoxide reductase
FH039_06790	COG1013	pyruvate-flavodoxin oxidoreductase activity
FH039_06800	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FH039_06800	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FH039_06815	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FH039_06830	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
FH039_06830	COG1918	ferrous iron import across plasma membrane
FH039_06835	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FH039_06855	COG1120	ATPase activity
FH039_06865	COG0640	Transcriptional regulator
FH039_06920	COG2217	Heavy metal translocating P-type atpase
FH039_06940	COG2217	Heavy metal translocating P-type atpase
FH039_06965	COG0450	alkyl hydroperoxide reductase
FH039_06970	COG0243	molybdopterin cofactor binding
FH039_06980	COG0307	riboflavin synthase, alpha
FH039_06985	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FH039_06985	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FH039_07040	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FH039_07070	COG0477	Major facilitator Superfamily
FH039_07075	COG2814	Major facilitator Superfamily
FH039_07105	COG1794	racemase activity, acting on amino acids and derivatives
FH039_07110	COG0668	transmembrane transport
FH039_07125	COG1993	acr, cog1993
FH039_07130	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FH039_07160	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FH039_07185	COG0312	modulator of DNA gyrase
FH039_07215	COG1794	racemase activity, acting on amino acids and derivatives
FH039_07225	COG0012	GTP binding
FH039_07240	COG0163	prenyltransferase activity
FH039_07255	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
FH039_07285	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FH039_07290	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FH039_07295	COG1984	allophanate hydrolase subunit 2
FH039_07305	COG1454	alcohol dehydrogenase
FH039_07315	COG0483	inositol monophosphate 1-phosphatase activity
FH039_07345	COG0546	phosphoglycolate phosphatase activity
FH039_07395	COG2001	Belongs to the MraZ family
FH039_07405	COG1363	Peptidase, m42
FH039_07415	COG2409	Drug exporters of the RND superfamily
FH039_07440	COG2814	Major facilitator Superfamily
FH039_07450	COG2096	Adenosyltransferase
FH039_07460	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
FH039_07475	COG1058	Belongs to the CinA family
FH039_07475	COG1546	Belongs to the CinA family
FH039_07490	COG1872	DUF167
FH039_07505	COG2361	Protein of unknown function DUF86
FH039_07510	COG0423	glycine-tRNA ligase activity
FH039_07530	COG0534	Mate efflux family protein
FH039_07565	COG2723	6-phospho-beta-galactosidase activity
FH039_07575	COG0601	transmembrane transport
FH039_07585	COG0444	Belongs to the ABC transporter superfamily
FH039_07590	COG4608	Belongs to the ABC transporter superfamily
FH039_07595	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FH039_07605	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
FH039_07620	COG0006	proline dipeptidase activity
FH039_07670	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FH039_07680	COG0330	HflC and HflK could
FH039_07685	COG2894	cell division
FH039_07700	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
FH039_07740	COG0525	valine-tRNA ligase activity
FH039_07760	COG2226	methyltransferase
FH039_07775	COG0714	Associated with various cellular activities
FH039_07790	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FH039_07795	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
FH039_07800	COG1573	uracil-dna glycosylase
FH039_07810	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FH039_07825	COG1598	PFAM Uncharacterised protein family UPF0150
FH039_07830	COG2342	PFAM TM1410 hypothetical-related protein
FH039_07835	COG0746	molybdenum cofactor guanylyltransferase activity
FH039_07845	COG1492	cobalamin metabolic process
FH039_07850	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FH039_07870	COG0521	Mo-molybdopterin cofactor biosynthetic process
FH039_07880	COG0303	'Molybdopterin
FH039_07900	COG1078	dGTPase activity
FH039_07915	COG2819	hydrolase of the alpha beta superfamily
FH039_07930	COG1899	peptidyl-lysine modification to peptidyl-hypusine
FH039_07935	COG1028	Short-chain dehydrogenase reductase Sdr
FH039_07940	COG1335	isochorismatase
FH039_07945	COG0492	ferredoxin-NADP+ reductase activity
FH039_07970	COG0501	Belongs to the peptidase M48B family
FH039_07975	COG1132	(ABC) transporter
FH039_07985	COG0459	protein refolding
FH039_07990	COG0515	serine threonine protein kinase
FH039_07995	COG0840	transmembrane signaling receptor activity
FH039_08000	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FH039_08020	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
FH039_08030	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FH039_08065	COG0126	phosphoglycerate kinase activity
FH039_08090	COG3842	ATPase activity
FH039_08095	COG1178	ABC-type Fe3 transport system permease component
FH039_08115	COG1522	sequence-specific DNA binding
FH039_08140	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FH039_08145	COG1122	ATPase activity
FH039_08155	COG1268	BioY protein
FH039_08170	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
FH039_08195	COG4946	Tricorn protease homolog
FH039_08195	COG1506	peptidase
FH039_08195	COG0823	Involved in the tonB-independent uptake of proteins
FH039_08205	COG1444	tRNA N-acetyltransferase activity
FH039_08225	COG4143	(ABC) transporter
FH039_08245	COG0017	Asparaginyl-tRNA synthetase
FH039_08250	COG0402	S-adenosylhomocysteine deaminase activity
FH039_08265	COG2815	serine threonine protein kinase
FH039_08265	COG0515	serine threonine protein kinase
FH039_08285	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FH039_08295	COG2815	serine threonine protein kinase
FH039_08295	COG0515	serine threonine protein kinase
FH039_08300	COG0631	protein serine/threonine phosphatase activity
FH039_08305	COG2815	serine threonine protein kinase
FH039_08305	COG0515	serine threonine protein kinase
FH039_08315	COG0515	serine threonine protein kinase
FH039_08315	COG2815	serine threonine protein kinase
FH039_08355	COG0175	sulfate reduction
FH039_08400	COG0105	UTP biosynthetic process
FH039_08425	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FH039_08435	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FH039_08480	COG0315	cyclic pyranopterin monophosphate synthase activity
FH039_08505	COG1131	(ABC) transporter
FH039_08530	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
FH039_08530	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FH039_08550	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FH039_08555	COG1216	Glycosyl transferase, family 2
FH039_08595	COG1739	Uncharacterized protein family UPF0029
FH039_08615	COG1111	helicase
FH039_08615	COG1205	dead DEAH box helicase
FH039_08630	COG1518	maintenance of DNA repeat elements
FH039_08635	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
FH039_08695	COG1121	(ABC) transporter
FH039_08735	COG2403	cyclic 2,3-diphosphoglycerate synthetase activity
FH039_08750	COG1373	ATPase (AAA superfamily
FH039_08765	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FH039_08770	COG2414	aldehyde ferredoxin oxidoreductase
FH039_08800	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FH039_08815	COG0051	transcription antitermination factor activity, RNA binding
FH039_08820	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FH039_08830	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FH039_08835	COG1078	dGTPase activity
FH039_08850	COG1469	GTP cyclohydrolase I activity
FH039_08865	COG1401	restriction endodeoxyribonuclease activity
FH039_08890	COG1185	polyribonucleotide nucleotidyltransferase activity
FH039_08905	COG1121	(ABC) transporter
FH039_08915	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FH039_08925	COG0455	bacterial-type flagellum organization
FH039_08930	COG0489	protein tyrosine kinase activity
FH039_08960	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FH039_09020	COG1342	Belongs to the UPF0251 family
FH039_09030	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FH039_09055	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
FH039_09075	COG1201	RNA secondary structure unwinding
FH039_09105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FH039_09110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FH039_09125	COG0084	hydrolase, TatD family'
FH039_09160	COG0419	ATPase involved in DNA repair
FH039_09160	COG0419	ATPase involved in DNA repair
FH039_09190	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FH039_09195	COG2894	cell division
FH039_09200	COG4956	integral membrane protein (PIN domain superfamily)
FH039_09220	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FH039_09225	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FH039_09225	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FH039_09245	COG1196	nuclear chromosome segregation
FH039_09275	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FH039_09305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FH039_09305	COG0045	succinate-CoA ligase (ADP-forming) activity
FH039_09305	COG1042	CoA-binding domain protein
FH039_09325	COG0301	tRNA thio-modification
FH039_09345	COG0301	tRNA thio-modification
FH039_09355	COG0778	Nitroreductase
FH039_09385	COG1215	transferase activity, transferring glycosyl groups
FH039_09415	COG1199	ATP-dependent helicase activity
FH039_09480	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
FH039_09535	COG1051	belongs to the nudix hydrolase family
FH039_09535	COG1056	cytidyltransferase-related domain
FH039_09545	COG0641	radical SAM
FH039_09600	COG1247	-acetyltransferase
FH039_09675	COG0739	heme binding
FH039_09705	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FH039_09705	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FH039_09715	COG0778	Nitroreductase
FH039_09720	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FH039_09780	COG0071	Belongs to the small heat shock protein (HSP20) family
FH039_09785	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FH039_09785	COG1793	dna ligase
FH039_09880	COG0045	succinate-CoA ligase (ADP-forming) activity
FH039_09880	COG1042	CoA-binding domain protein
FH039_09880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FH039_09895	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FH039_09905	COG0303	'Molybdopterin
FH039_09910	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FH039_09935	COG0009	L-threonylcarbamoyladenylate synthase
FH039_09950	COG0367	asparagine synthase
FH039_09975	COG0560	Phosphoserine phosphatase
FH039_09980	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FH039_10070	COG0835	chemotaxis
FH039_10075	COG0840	transmembrane signaling receptor activity
FH039_10085	COG2201	protein-glutamate methylesterase activity
FH039_10090	COG2201	protein-glutamate methylesterase activity
FH039_10095	COG0643	Histidine kinase
FH039_10095	COG2198	Histidine kinase
FH039_10110	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
FH039_10115	COG0840	transmembrane signaling receptor activity
FH039_10160	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
FH039_10165	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FH039_10175	COG1106	Psort location Cytoplasmic, score
FH039_10180	COG3842	ATPase activity
FH039_10185	COG4149	molybdate abc transporter
FH039_10190	COG0725	ABC transporter, periplasmic molybdate-binding protein
FH039_10210	COG1160	GTP binding
FH039_10215	COG0432	Pfam Uncharacterised protein family UPF0047
FH039_10235	COG1832	CoA-binding protein
FH039_10255	COG2379	hydroxypyruvate reductase
FH039_10275	COG1435	thymidine kinase activity
FH039_10280	COG1850	ribulose-bisphosphate carboxylase activity
FH039_10325	COG1131	(ABC) transporter
FH039_10355	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FH039_10370	COG0284	orotidine-5'-phosphate decarboxylase activity
FH039_10380	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FH039_10380	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FH039_10390	COG1192	Involved in chromosome partitioning
FH039_10395	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FH039_10415	COG2119	membrane
FH039_10430	COG0535	radical SAM domain protein
FH039_10435	COG2414	aldehyde ferredoxin oxidoreductase
FH039_10440	COG1404	Belongs to the peptidase S8 family
FH039_10465	COG2151	metal-sulfur cluster biosynthetic enzyme
FH039_10470	COG1141	Ferredoxin
FH039_10480	COG1028	Short-chain dehydrogenase reductase Sdr
FH039_10505	COG0493	'glutamate synthase
FH039_10510	COG0543	2 iron, 2 sulfur cluster binding
FH039_10545	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FH039_10550	COG0167	dihydroorotate dehydrogenase activity
FH039_10575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FH039_10615	COG0446	pyridine nucleotide-disulphide oxidoreductase
FH039_10620	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FH039_10650	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FH039_10675	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FH039_10685	COG0693	protein deglycase activity
FH039_10695	COG1983	PspC domain protein
FH039_10720	COG2095	MarC family integral membrane protein
FH039_10725	COG1765	OsmC-like protein
FH039_10735	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FH039_10740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FH039_10745	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
FH039_10770	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FH039_10835	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FH039_10840	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FH039_10870	COG1402	creatininase
FH039_10875	COG0438	transferase activity, transferring glycosyl groups
FH039_10880	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FH039_10885	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FH039_10915	COG0651	ATP synthesis coupled electron transport
FH039_10940	COG1320	monovalent cation:proton antiporter activity
FH039_10945	COG2212	antiporter activity
FH039_10950	COG1863	multisubunit Na H antiporter MnhE subunit
FH039_10960	COG0509	glycine decarboxylation via glycine cleavage system
FH039_10975	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
FH039_10975	COG0493	'glutamate synthase
FH039_10980	COG0543	2 iron, 2 sulfur cluster binding
FH039_11010	COG0747	negative chemotaxis
FH039_11015	COG0601	transmembrane transport
FH039_11025	COG0444	Belongs to the ABC transporter superfamily
FH039_11030	COG4608	Belongs to the ABC transporter superfamily
FH039_11070	COG1131	(ABC) transporter
FH039_11080	COG1476	TRANSCRIPTIONal
FH039_11110	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FH039_11115	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FH039_11155	COG0210	DNA helicase
FH039_11170	COG0501	Belongs to the peptidase M48B family
FH039_11175	COG2131	deaminase
FH039_11185	COG0546	phosphoglycolate phosphatase activity
FH039_11190	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FH039_11200	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FH039_11205	COG2814	Major facilitator Superfamily
FH039_11230	COG1446	asparaginase
FH039_11250	COG2226	methyltransferase
FH039_11255	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
FH039_11320	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
FH039_11345	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FH039_11385	COG0156	8-amino-7-oxononanoate synthase activity
FH039_11400	COG1214	PFAM Peptidase M22, glycoprotease
FH039_11400	COG0456	acetyltransferase
FH039_11405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FH039_11410	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FH039_11445	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FH039_11470	COG0432	Pfam Uncharacterised protein family UPF0047
FH039_11485	COG0540	Belongs to the ATCase OTCase family
FH039_11490	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
FH039_11535	COG1988	membrane-bound metal-dependent
FH039_11575	COG0434	BtpA family
FH039_11580	COG1305	Transglutaminase-like
FH039_11590	COG0714	Associated with various cellular activities
FH039_11625	COG0312	modulator of DNA gyrase
FH039_11645	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FH039_11660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FH039_11705	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FH039_11715	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FH039_11720	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
FH039_11765	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FH039_11785	COG0674	pyruvate-flavodoxin oxidoreductase activity
FH039_11790	COG1013	pyruvate-flavodoxin oxidoreductase activity
FH039_11800	COG0674	pyruvate-flavodoxin oxidoreductase activity
FH039_11805	COG1013	pyruvate-flavodoxin oxidoreductase activity
FH039_11810	COG0746	molybdenum cofactor guanylyltransferase activity
FH039_11825	COG4139	cobalamin transport
FH039_11830	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FH039_11835	COG0489	protein tyrosine kinase activity
FH039_11860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FH039_11870	COG1254	Belongs to the acylphosphatase family
FH039_11880	COG1628	Protein of unknown function DUF99
FH039_11885	COG0589	response to stress
FH039_11895	COG0697	spore germination
FH039_11955	COG1233	COG1233 Phytoene dehydrogenase and related
FH039_11965	COG1980	fructose-bisphosphate aldolase activity
FH039_11985	COG1522	sequence-specific DNA binding
FH039_12000	COG2894	cell division
FH039_12005	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FH039_12025	COG1757	Na H antiporter
FH039_12030	COG1573	uracil-dna glycosylase