Thal_0016 SM00487 DEAD-like helicases superfamily Thal_0016 SM00490 helicase superfamily c-terminal domain Thal_0018 SM00530 Helix-turn-helix XRE-family like proteins Thal_0021 SM00382 ATPases associated with a variety of cellular activities Thal_0027 SM00929 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region Thal_0029 SM00642 Alpha-amylase domain Thal_0052 SM01130 Thal_0052 Thal_0053 SM00470 ParB-like nuclease domain Thal_0054 SM00831 Cation transporter/ATPase, N-terminus Thal_0055 SM00028 Tetratricopeptide repeats Thal_0056 SM00271 DnaJ molecular chaperone homology domain Thal_0057 SM00422 helix_turn_helix, mercury resistance Thal_0064 SM01228 Thal_0064 Thal_0067 SM00788 Adenylosuccinate synthetase Thal_0076 SM00729 Elongator protein 3, MiaB family, Radical SAM Thal_0087 SM00420 helix_turn_helix, Deoxyribose operon repressor Thal_0089 SM00436 Bacterial DNA topoisomeraes I ATP-binding domain Thal_0089 SM00437 Bacterial DNA topoisomerase I DNA-binding domain Thal_0089 SM00487 DEAD-like helicases superfamily Thal_0089 SM00493 Thal_0089 Thal_0096 SM00358 Double-stranded RNA binding motif Thal_0096 SM00535 Ribonuclease III family Thal_0097 SM00825 Beta-ketoacyl synthase Thal_0098 SM00823 Phosphopantetheine attachment site Thal_0107 SM00855 Phosphoglycerate mutase family Thal_0119 SM00382 ATPases associated with a variety of cellular activities Thal_0121 SM00926 Molybdopterin oxidoreductase Fe4S4 domain Thal_0128 SM00363 S4 RNA-binding domain Thal_0143 SM00382 ATPases associated with a variety of cellular activities Thal_0147 SM00732 Likely ribonuclease with RNase H fold. Thal_0154 SM00382 ATPases associated with a variety of cellular activities Thal_0155 SM00448 cheY-homologous receiver domain Thal_0155 SM00862 Transcriptional regulatory protein, C terminal Thal_0163 SM00851 MGS-like domain Thal_0164 SM00382 ATPases associated with a variety of cellular activities Thal_0177 SM00382 ATPases associated with a variety of cellular activities Thal_0177 SM00760 Bacterial dnaA protein helix-turn-helix domain Thal_0182 SM00996 S-adenosyl-L-homocysteine hydrolase Thal_0182 SM00997 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Thal_0186 SM00465 GIY-YIG type nucleases (URI domain) Thal_0188 SM01152 Thal_0188 Thal_0189 SM00331 Sigma factor PP2C-like phosphatases Thal_0189 SM00332 Serine/threonine phosphatases, family 2C, catalytic domain Thal_0194 SM01207 Thal_0194 Thal_0197 SM00487 DEAD-like helicases superfamily Thal_0197 SM00490 helicase superfamily c-terminal domain Thal_0200 SM00881 CoA binding domain Thal_0204 SM00382 ATPases associated with a variety of cellular activities Thal_0208 SM00479 Thal_0208 Thal_0212 SM00957 SecA DEAD-like domain Thal_0212 SM00958 SecA preprotein cross-linking domain Thal_0216 SM01400 Thal_0216 Thal_0217 SM00533 DNA-binding domain of DNA mismatch repair MUTS family Thal_0217 SM00534 ATPase domain of DNA mismatch repair MUTS family Thal_0218 SM00322 K homology RNA-binding domain Thal_0218 SM00471 Metal dependent phosphohydrolases with conserved 'HD' motif. Thal_0220 SM00873 B3/4 domain Thal_0220 SM00874 tRNA synthetase B5 domain Thal_0220 SM00896 Ferredoxin-fold anticodon binding domain Thal_0228 SM00899 Thal_0228 Thal_0236 SM00704 CDGSH-type zinc finger. Function unknown. Thal_0239 SM00382 ATPases associated with a variety of cellular activities Thal_0243 SM00646 Thal_0243 Thal_0252 SM00938 Nitrogen regulatory protein P-II Thal_0257 SM00478 endonuclease III Thal_0257 SM00525 Thal_0257 Thal_0267 SM00878 Biotin carboxylase C-terminal domain Thal_0279 SM00434 DNA Topoisomerase IV Thal_0284 SM00382 ATPases associated with a variety of cellular activities Thal_0287 SM00387 Histidine kinase-like ATPases Thal_0287 SM00388 His Kinase A (phosphoacceptor) domain Thal_0298 SM00382 ATPases associated with a variety of cellular activities Thal_0299 SM00984 UDP binding domain Thal_0300 SM00836 DALR anticodon binding domain Thal_0300 SM01016 Arginyl tRNA synthetase N terminal dom Thal_0302 SM00028 Tetratricopeptide repeats Thal_0305 SM00357 Cold shock protein domain Thal_0305 SM00382 ATPases associated with a variety of cellular activities Thal_0305 SM00959 Rho termination factor, N-terminal domain Thal_0309 SM00052 Putative diguanylate phosphodiesterase Thal_0309 SM00267 diguanylate cyclase Thal_0314 SM00849 Metallo-beta-lactamase superfamily Thal_0315 SM00481 DNA polymerase alpha chain like domain Thal_0318 SM00729 Elongator protein 3, MiaB family, Radical SAM Thal_0320 SM00448 cheY-homologous receiver domain Thal_0320 SM00862 Transcriptional regulatory protein, C terminal Thal_0321 SM00304 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain Thal_0321 SM00387 Histidine kinase-like ATPases Thal_0321 SM00388 His Kinase A (phosphoacceptor) domain Thal_0333 SM01005 Alanine racemase, C-terminal domain Thal_0334 SM00028 Tetratricopeptide repeats Thal_0340 SM00518 AP endonuclease family 2 Thal_0343 SM00840 Thal_0343 Thal_0344 SM00852 Probable molybdopterin binding domain Thal_0350 SM00966 SpoVT / AbrB like domain Thal_0359 SM00271 DnaJ molecular chaperone homology domain Thal_0361 SM00116 Domain in cystathionine beta-synthase and other proteins. Thal_0366 SM00563 Phosphate acyltransferases Thal_0367 SM01323 Thal_0367 Thal_0371 SM00478 endonuclease III Thal_0384 SM00864 Tubulin/FtsZ family, GTPase domain Thal_0384 SM00865 Tubulin/FtsZ family, C-terminal domain Thal_0385 SM00842 Cell division protein FtsA Thal_0396 SM00065 Domain present in phytochromes and cGMP-specific phosphodiesterases. Thal_0396 SM00382 ATPases associated with a variety of cellular activities Thal_0404 SM00989 Thal_0404 Thal_0407 SM00729 Elongator protein 3, MiaB family, Radical SAM Thal_0410 SM00938 Nitrogen regulatory protein P-II Thal_0411 SM00938 Nitrogen regulatory protein P-II Thal_0413 SM00729 Elongator protein 3, MiaB family, Radical SAM Thal_0420 SM00790 Aldehyde ferredoxin oxidoreductase, N-terminal domain Thal_0423 SM00065 Domain present in phytochromes and cGMP-specific phosphodiesterases. Thal_0423 SM00382 ATPases associated with a variety of cellular activities Thal_0441 SM00228 Domain present in PSD-95, Dlg, and ZO-1/2. Thal_0441 SM00245 tail specific protease Thal_0444 SM00257 Lysin motif Thal_0454 SM00506 Appr-1"-p processing enzyme Thal_0465 SM00072 Guanylate kinase homologues. Thal_0466 SM01409 Thal_0466 Thal_0482 SM00729 Elongator protein 3, MiaB family, Radical SAM Thal_0484 SM00960 Roadblock/LC7 domain Thal_0487 SM00859 Semialdehyde dehydrogenase, NAD binding domain Thal_0495 SM00487 DEAD-like helicases superfamily Thal_0495 SM00490 helicase superfamily c-terminal domain Thal_0497 SM00327 von Willebrand factor (vWF) type A domain Thal_0499 SM00387 Histidine kinase-like ATPases Thal_0499 SM00388 His Kinase A (phosphoacceptor) domain Thal_0500 SM00382 ATPases associated with a variety of cellular activities Thal_0500 SM00448 cheY-homologous receiver domain Thal_0508 SM00448 cheY-homologous receiver domain Thal_0509 SM00283 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thal_0511 SM00260 Two component signalling adaptor domain Thal_0511 SM00448 cheY-homologous receiver domain Thal_0512 SM00073 Histidine Phosphotransfer domain Thal_0512 SM00260 Two component signalling adaptor domain Thal_0512 SM00387 Histidine kinase-like ATPases Thal_0512 SM01231 Thal_0512 Thal_0513 SM00260 Two component signalling adaptor domain Thal_0514 SM00271 DnaJ molecular chaperone homology domain Thal_0516 SM00998 Adenylosuccinate lyase C-terminus Thal_0539 SM01133 Thal_0539 Thal_0557 SM00562 Thal_0557 Thal_0563 SM00845 GatB domain Thal_0575 SM01192 Thal_0575 Thal_0575 SM01193 Thal_0575 Thal_0578 SM00935 Outer membrane protein (OmpH-like) Thal_0579 SM00382 ATPases associated with a variety of cellular activities Thal_0579 SM00994 ClpX C4-type zinc finger Thal_0579 SM01086 C-terminal, D2-small domain, of ClpB protein Thal_0585 SM00304 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain Thal_0585 SM00387 Histidine kinase-like ATPases Thal_0585 SM00388 His Kinase A (phosphoacceptor) domain Thal_0589 SM00363 S4 RNA-binding domain Thal_0591 SM00650 Ribosomal RNA adenine dimethylases Thal_0592 SM01329 Thal_0592 Thal_0596 SM00226 Low molecular weight phosphatase family Thal_0600 SM00450 Rhodanese Homology Domain Thal_0603 SM00382 ATPases associated with a variety of cellular activities Thal_0603 SM00962 SRP54-type protein, GTPase domain Thal_0603 SM00963 SRP54-type protein, helical bundle domain Thal_0604 SM00382 ATPases associated with a variety of cellular activities Thal_0604 SM00464 Found in ATP-dependent protease La (LON) Thal_0612 SM00322 K homology RNA-binding domain Thal_0615 SM01382 Thal_0615 Thal_0615 SM01383 Thal_0615 Thal_0619 SM01403 Thal_0619 Thal_0621 SM00838 Elongation factor G C-terminus Thal_0621 SM00889 Elongation factor G, domain IV Thal_0624 SM00663 RNA polymerase I subunit A N-terminus Thal_0629 SM00649 Ribosomal protein L11/L12 Thal_0630 SM00738 In Spt5p, this domain may confer affinity for Spt4p. It possesses a RNP-like fold. Thal_0630 SM00739 KOW (Kyprides, Ouzounis, Woese) motif. Thal_0637 SM00052 Putative diguanylate phosphodiesterase Thal_0644 SM00904 Riboflavin kinase Thal_0646 SM01329 Thal_0646 Thal_0648 SM00822 Thal_0648 Thal_0650 SM00028 Tetratricopeptide repeats Thal_0671 SM00478 endonuclease III Thal_0671 SM00525 Thal_0671 Thal_0682 SM00267 diguanylate cyclase Thal_0690 SM00382 ATPases associated with a variety of cellular activities Thal_0690 SM01086 C-terminal, D2-small domain, of ClpB protein Thal_0691 SM00968 SMC proteins Flexible Hinge Domain Thal_0693 SM00382 ATPases associated with a variety of cellular activities Thal_0693 SM01086 C-terminal, D2-small domain, of ClpB protein Thal_0698 SM00316 Ribosomal protein S1-like RNA-binding domain Thal_0703 SM00471 Metal dependent phosphohydrolases with conserved 'HD' motif. Thal_0704 SM00460 Transglutaminase/protease-like homologues Thal_0706 SM00382 ATPases associated with a variety of cellular activities Thal_0711 SM00382 ATPases associated with a variety of cellular activities Thal_0716 SM00382 ATPases associated with a variety of cellular activities Thal_0725 SM00382 ATPases associated with a variety of cellular activities Thal_0732 SM00065 Domain present in phytochromes and cGMP-specific phosphodiesterases. Thal_0732 SM00091 PAS domain Thal_0732 SM00116 Domain in cystathionine beta-synthase and other proteins. Thal_0732 SM00267 diguanylate cyclase Thal_0739 SM00363 S4 RNA-binding domain Thal_0742 SM00662 RNA polymerases D Thal_0743 SM00363 S4 RNA-binding domain Thal_0743 SM01390 Thal_0743 Thal_0747 SM00316 Ribosomal protein S1-like RNA-binding domain Thal_0759 SM00739 KOW (Kyprides, Ouzounis, Woese) motif. Thal_0760 SM01374 Thal_0760 Thal_0761 SM00729 Elongator protein 3, MiaB family, Radical SAM Thal_0770 SM01321 Thal_0770 Thal_0773 SM00316 Ribosomal protein S1-like RNA-binding domain Thal_0773 SM00322 K homology RNA-binding domain Thal_0774 SM01387 Thal_0774 Thal_0779 SM00100 Cyclic nucleotide-monophosphate binding domain Thal_0779 SM00116 Domain in cystathionine beta-synthase and other proteins. Thal_0790 SM00878 Biotin carboxylase C-terminal domain Thal_0803 SM00463 Small MutS-related domain Thal_0803 SM00533 DNA-binding domain of DNA mismatch repair MUTS family Thal_0803 SM00534 ATPase domain of DNA mismatch repair MUTS family Thal_0807 SM00382 ATPases associated with a variety of cellular activities Thal_0815 SM00382 ATPases associated with a variety of cellular activities Thal_0815 SM00962 SRP54-type protein, GTPase domain Thal_0815 SM00963 SRP54-type protein, helical bundle domain Thal_0816 SM00028 Tetratricopeptide repeats Thal_0840 SM00926 Molybdopterin oxidoreductase Fe4S4 domain Thal_0842 SM00852 Probable molybdopterin binding domain Thal_0844 SM00382 ATPases associated with a variety of cellular activities Thal_0850 SM01097 Carbamoyl-phosphate synthase small chain, CPSase domain Thal_0851 SM00316 Ribosomal protein S1-like RNA-binding domain Thal_0851 SM00357 Cold shock protein domain Thal_0851 SM00955 Thal_0851 Thal_0852 SM00861 Transketolase, pyrimidine binding domain Thal_0864 SM00411 bacterial (prokaryotic) histone like domain Thal_0866 SM00930 Thal_0866 Thal_0868 SM00382 ATPases associated with a variety of cellular activities Thal_0868 SM00448 cheY-homologous receiver domain Thal_0878 SM00028 Tetratricopeptide repeats Thal_0879 SM00855 Phosphoglycerate mutase family Thal_0894 SM00382 ATPases associated with a variety of cellular activities Thal_0903 SM00052 Putative diguanylate phosphodiesterase Thal_0903 SM00267 diguanylate cyclase Thal_0911 SM00382 ATPases associated with a variety of cellular activities Thal_0912 SM00116 Domain in cystathionine beta-synthase and other proteins. Thal_0915 SM00116 Domain in cystathionine beta-synthase and other proteins. Thal_0915 SM01091 Transporter associated domain Thal_0919 SM00382 ATPases associated with a variety of cellular activities Thal_0920 SM00846 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain Thal_0924 SM00838 Elongation factor G C-terminus Thal_0925 SM01001 AIR carboxylase Thal_0926 SM00729 Elongator protein 3, MiaB family, Radical SAM Thal_0926 SM00876 Biotin and Thiamin Synthesis associated domain Thal_0929 SM00830 Chorismate mutase type II Thal_0931 SM00244 prohibitin homologues Thal_0937 SM00878 Biotin carboxylase C-terminal domain Thal_0944 SM00267 diguanylate cyclase Thal_0946 SM00928 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region Thal_0947 SM00986 Uracil DNA glycosylase superfamily Thal_0947 SM00987 UreE urease accessory protein, C-terminal domain Thal_0950 SM00487 DEAD-like helicases superfamily Thal_0950 SM00490 helicase superfamily c-terminal domain Thal_0955 SM00279 Helix-hairpin-helix class 2 (Pol1 family) motifs Thal_0955 SM00475 5'-3' exonuclease Thal_0959 SM00926 Molybdopterin oxidoreductase Fe4S4 domain Thal_0966 SM00863 Threonyl and Alanyl tRNA synthetase second additional domain Thal_0967 SM00563 Phosphate acyltransferases Thal_0972 SM00052 Putative diguanylate phosphodiesterase Thal_0972 SM00267 diguanylate cyclase Thal_0985 SM00359 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase Thal_0990 SM00917 LeuA allosteric (dimerisation) domain Thal_0992 SM00228 Domain present in PSD-95, Dlg, and ZO-1/2. Thal_0994 SM00989 Thal_0994 Thal_1000 SM00116 Domain in cystathionine beta-synthase and other proteins. Thal_1000 SM01091 Transporter associated domain Thal_1001 SM00382 ATPases associated with a variety of cellular activities Thal_1002 SM00729 Elongator protein 3, MiaB family, Radical SAM Thal_1003 SM00382 ATPases associated with a variety of cellular activities Thal_1004 SM01004 Delta-aminolevulinic acid dehydratase Thal_1010 SM01209 Thal_1010 Thal_1010 SM01210 Thal_1010 Thal_1012 SM00967 RNA 2'-O ribose methyltransferase substrate binding Thal_1024 SM00934 Orotidine 5'-phosphate decarboxylase / HUMPS family Thal_1025 SM00917 LeuA allosteric (dimerisation) domain Thal_1029 SM00316 Ribosomal protein S1-like RNA-binding domain Thal_1039 SM00382 ATPases associated with a variety of cellular activities Thal_1047 SM00382 ATPases associated with a variety of cellular activities Thal_1055 SM00382 ATPases associated with a variety of cellular activities Thal_1064 SM00028 Tetratricopeptide repeats Thal_1068 SM00028 Tetratricopeptide repeats Thal_1071 SM00729 Elongator protein 3, MiaB family, Radical SAM Thal_1074 SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. Thal_1085 SM00228 Domain present in PSD-95, Dlg, and ZO-1/2. Thal_1085 SM00245 tail specific protease Thal_1092 SM00829 Enoylreductase Thal_1110 SM00382 ATPases associated with a variety of cellular activities Thal_1118 SM00382 ATPases associated with a variety of cellular activities Thal_1124 SM00729 Elongator protein 3, MiaB family, Radical SAM Thal_1137 SM00450 Rhodanese Homology Domain Thal_1149 SM00382 ATPases associated with a variety of cellular activities Thal_1153 SM00900 Thal_1153 Thal_1155 SM00400 zinc finger Thal_1155 SM00493 Thal_1155 Thal_1156 SM00881 CoA binding domain Thal_1167 SM00382 ATPases associated with a variety of cellular activities Thal_1167 SM00962 SRP54-type protein, GTPase domain Thal_1170 SM00316 Ribosomal protein S1-like RNA-binding domain Thal_1174 SM00382 ATPases associated with a variety of cellular activities Thal_1176 SM00471 Metal dependent phosphohydrolases with conserved 'HD' motif. Thal_1176 SM00954 Region found in RelA / SpoT proteins Thal_1184 SM01234 Thal_1184 Thal_1201 SM00478 endonuclease III Thal_1203 SM00116 Domain in cystathionine beta-synthase and other proteins. Thal_1203 SM01240 Thal_1203 Thal_1220 SM00849 Metallo-beta-lactamase superfamily Thal_1223 SM00480 DNA polymerase III beta subunit Thal_1225 SM00382 ATPases associated with a variety of cellular activities Thal_1226 SM00318 Staphylococcal nuclease homologues Thal_1228 SM00436 Bacterial DNA topoisomeraes I ATP-binding domain Thal_1228 SM00437 Bacterial DNA topoisomerase I DNA-binding domain Thal_1228 SM00493 Thal_1228 Thal_1241 SM01007 Class II Aldolase and Adducin N-terminal domain Thal_1243 SM00984 UDP binding domain Thal_1246 SM00474 3'-5' exonuclease Thal_1246 SM00482 DNA polymerase A domain Thal_1248 SM00729 Elongator protein 3, MiaB family, Radical SAM Thal_1258 SM00228 Domain present in PSD-95, Dlg, and ZO-1/2. Thal_1270 SM00382 ATPases associated with a variety of cellular activities Thal_1270 SM01086 C-terminal, D2-small domain, of ClpB protein Thal_1286 SM00487 DEAD-like helicases superfamily Thal_1288 SM00267 diguanylate cyclase Thal_1288 SM00304 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain Thal_1291 SM00382 ATPases associated with a variety of cellular activities Thal_1297 SM00448 cheY-homologous receiver domain Thal_1297 SM00862 Transcriptional regulatory protein, C terminal Thal_1304 SM00448 cheY-homologous receiver domain Thal_1304 SM00862 Transcriptional regulatory protein, C terminal Thal_1309 SM00411 bacterial (prokaryotic) histone like domain Thal_1311 SM00938 Nitrogen regulatory protein P-II Thal_1312 SM01230 Thal_1312 Thal_1318 SM00926 Molybdopterin oxidoreductase Fe4S4 domain Thal_1319 SM00382 ATPases associated with a variety of cellular activities Thal_1322 SM01116 Thal_1322 Thal_1323 SM00938 Nitrogen regulatory protein P-II Thal_1324 SM00938 Nitrogen regulatory protein P-II Thal_1333 SM00487 DEAD-like helicases superfamily Thal_1333 SM00490 helicase superfamily c-terminal domain Thal_1338 SM00729 Elongator protein 3, MiaB family, Radical SAM Thal_1358 SM00418 helix_turn_helix, Arsenical Resistance Operon Repressor Thal_1367 SM00937 Thal_1367 Thal_1381 SM00487 DEAD-like helicases superfamily Thal_1381 SM00490 helicase superfamily c-terminal domain Thal_1382 SM00861 Transketolase, pyrimidine binding domain Thal_1384 SM00100 Cyclic nucleotide-monophosphate binding domain Thal_1384 SM00419 helix_turn_helix, cAMP Regulatory protein Thal_1398 SM00387 Histidine kinase-like ATPases Thal_1398 SM00433 TopoisomeraseII Thal_1405 SM00028 Tetratricopeptide repeats Thal_1429 SM00220 Serine/Threonine protein kinases, catalytic domain Thal_1433 SM00028 Tetratricopeptide repeats Thal_1446 SM00883 Chaperonin 10 Kd subunit Thal_1448 SM01340 Thal_1448 Thal_1460 SM00357 Cold shock protein domain Thal_1494 SM00493 Thal_1494 Thal_1499 SM00228 Domain present in PSD-95, Dlg, and ZO-1/2. Thal_1511 SM01096 Carbamoyl-phosphate synthetase large chain, oligomerisation domain Thal_1515 SM00232 JAB/MPN domain Thal_1516 SM00859 Semialdehyde dehydrogenase, NAD binding domain Thal_1535 SM00841 Elongation factor P, C-terminal Thal_1535 SM01185 Thal_1535 Thal_1543 SM00155 Phospholipase D. Active site motifs. Thal_1543 SM00382 ATPases associated with a variety of cellular activities Thal_1544 SM00937 Thal_1544 Thal_1546 SM00863 Threonyl and Alanyl tRNA synthetase second additional domain Thal_1560 SM00359 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase Thal_1561 SM00881 CoA binding domain Thal_1569 SM00989 Thal_1569 Thal_1580 SM01350 Thal_1580 Thal_1582 SM00798 AICARFT/IMPCHase bienzyme Thal_1582 SM00851 MGS-like domain Thal_1583 SM01211 Thal_1583 Thal_1585 SM00729 Elongator protein 3, MiaB family, Radical SAM Thal_1589 SM00278 Helix-hairpin-helix DNA-binding motif class 1 Thal_1589 SM00481 DNA polymerase alpha chain like domain Thal_1589 SM00483 DNA polymerase X family Thal_1590 SM00487 DEAD-like helicases superfamily Thal_1590 SM00490 helicase superfamily c-terminal domain