locus-tag class description THERU_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) THERU_00010 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) THERU_00015 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) THERU_00025 ENOG4105DGU Histone deacetylase THERU_00030 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) THERU_00035 ENOG4105VF7 tolerance protein THERU_00040 ENOG4105DDQ anthranilate synthase THERU_00045 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) THERU_00050 ENOG4105PW4 Sugar fermentation stimulation protein homolog THERU_00055 ENOG4105CB5 ATP-dependent DNA helicase recG THERU_00075 ENOG4105E3H phosphoglycerate mutase THERU_00085 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) THERU_00100 ENOG4105DD5 Flagellar motor switch protein THERU_00105 ENOG410847I Transcriptional regulator, BadM Rrf2 family THERU_00120 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) THERU_00125 ENOG4105WPN DNA integration recombination invertion protein THERU_00130 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) THERU_00150 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) THERU_00155 ENOG4108ZCA Inherit from COG: pyridine nucleotide-disulfide oxidoreductase THERU_00175 ENOG4107QN2 dihydrolipoyl dehydrogenase THERU_00195 ENOG4105RQ5 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) THERU_00210 ENOG4105PHD The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) THERU_00230 ENOG4108URH decarboxylase THERU_00240 ENOG4105EYH Exonuclease THERU_00245 ENOG4108K4H THERU_00250 ENOG4107VCH Bifunctional phosphoglucose phosphomannose isomerase THERU_00255 ENOG4105DU1 integral membrane protein, terc THERU_00260 ENOG4108JB5 Magnesium and cobalt efflux protein THERU_00265 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) THERU_00270 ENOG41085N6 Preprotein translocase subunit SecG THERU_00275 ENOG4106BF9 THERU_00290 ENOG4105M7V 2'-5' rna ligase THERU_00295 ENOG4105CXB phosphoribosylaminoimidazole synthetase THERU_00300 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane THERU_00310 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) THERU_00315 ENOG4107XR7 (6-pyruvoyl tetrahydrobiopterin) synthase THERU_00320 ENOG41085TX 30S ribosomal protein S21 THERU_00325 ENOG4105FGP Type IV pilus assembly THERU_00335 ENOG4105K63 Thioredoxin THERU_00345 ENOG4105PGM cation diffusion facilitator family transporter THERU_00355 ENOG4107S91 Sodium hydrogen exchanger THERU_00365 ENOG4105KNI merR family transcriptional Regulator THERU_00370 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) THERU_00375 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) THERU_00380 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) THERU_00395 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) THERU_00410 ENOG4105C03 ribonuclease THERU_00415 ENOG4108M79 outer membrane assembly lipoprotein YfiO THERU_00420 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) THERU_00430 ENOG4105CGA flagellar basal-body rod protein FlgG THERU_00440 ENOG4107XZW Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) THERU_00445 ENOG4105K70 DNA-binding protein THERU_00460 ENOG4105C0R drug resistance transporter emrb qaca subfamily THERU_00465 ENOG4105CW7 secretion protein, HlyD family THERU_00475 ENOG4108IG5 Transcriptional regulator THERU_00490 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) THERU_00495 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) THERU_00505 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) THERU_00510 ENOG4105DJV ribulose-phosphate 3-epimerase THERU_00515 ENOG4105D6E homoserine dehydrogenase THERU_00525 ENOG4105DZH s-adenosylmethionine synthetase (EC 2.5.1.6) THERU_00535 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) THERU_00545 ENOG4105D0U Arsenite-activated ATPase (ArsA) THERU_00550 ENOG4108UN4 phage SPO1 DNA polymerase-related protein THERU_00555 ENOG4107RB4 Cytidine monophosphate kinase THERU_00560 ENOG4105CZX twitching motility protein THERU_00565 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) THERU_00570 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) THERU_00575 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme THERU_00585 ENOG4105CMR udp-glucose 4-epimerase THERU_00595 ENOG4105PSQ Acyl-transferase THERU_00605 ENOG4105C0B DNA polymerase III (alpha subunit) THERU_00610 ENOG4108ZF3 Phosphatase THERU_00615 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen THERU_00640 ENOG4105CN1 protease THERU_00645 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) THERU_00650 ENOG4105D1U peptidase U62 modulator of DNA gyrase THERU_00655 ENOG4107QX8 SPFH domain, Band 7 family protein THERU_00665 ENOG4105CQC Prephenate dehydratase THERU_00675 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) THERU_00690 ENOG4105BZS acriflavin resistance protein THERU_00695 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) THERU_00705 ENOG4107QIV Cytochrome c biogenesis protein THERU_00710 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) THERU_00715 ENOG4108M29 THERU_00725 ENOG4105MQ3 flagellar protein FliS THERU_00730 ENOG410801E Flagellar hook-associated 2 domain-containing protein THERU_00735 ENOG41063QE flagellar protein FlaG THERU_00745 ENOG4105NZG Ferredoxin THERU_00750 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) THERU_00760 ENOG4105D0M Protease HtpX homolog THERU_00765 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) THERU_00770 ENOG4105F4G Membrane THERU_00780 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) THERU_00785 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) THERU_00790 ENOG4105W5Q DNA repair protein (RadC THERU_00800 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) THERU_00815 ENOG4105BZ9 Cytochrome C oxidase, subunit I THERU_00830 ENOG4105CCU oxidase (Subunit III) THERU_00835 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) THERU_00840 ENOG4105KNE Phosphatidate cytidylyltransferase THERU_00845 ENOG4105E4G Type IV pilus THERU_00870 ENOG41083MR nifu domain-containing protein THERU_00875 ENOG4105SFS phosphoesterase RecJ domain protein THERU_00880 ENOG4107QN2 dihydrolipoyl dehydrogenase THERU_00890 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) THERU_00895 ENOG4108327 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) THERU_00905 ENOG41084DJ Could be involved in insertion of integral membrane proteins into the membrane (By similarity) THERU_00910 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins THERU_00915 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) THERU_00920 ENOG4105BZU Histidine kinase THERU_00925 ENOG4106CKE THERU_00930 ENOG4105CXV gliding motility protein THERU_00945 ENOG4108UTW Plays a role in the regulation of phosphate uptake THERU_00950 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) THERU_00955 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) THERU_00960 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) THERU_00970 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain THERU_00975 ENOG4108Z4T Peptidase M50 THERU_00990 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) THERU_00995 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase THERU_01000 ENOG4107R76 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) THERU_01010 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) THERU_01015 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) THERU_01025 ENOG4105C31 Tryptophanyl-tRNA synthetase THERU_01040 ENOG4105DZP Membrane-associated zinc metalloprotease THERU_01060 ENOG4105CVJ phosphoglycerate mutase THERU_01065 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) THERU_01070 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) THERU_01085 ENOG4105DAN ATP-dependent protease THERU_01090 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase THERU_01105 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) THERU_01120 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase THERU_01125 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) THERU_01130 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) THERU_01140 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase THERU_01145 ENOG4107SC1 transglycosylase THERU_01155 ENOG4106HQT Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) THERU_01160 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) THERU_01170 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) THERU_01190 ENOG4105DFF Rod shape-determining protein mreb THERU_01195 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) THERU_01200 ENOG4105C79 DNA protecting protein DprA THERU_01205 ENOG4107ZP9 ComEC Rec2-related protein THERU_01210 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) THERU_01215 ENOG4107QMH DNA methylase THERU_01225 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) THERU_01230 ENOG4105DZP Membrane-associated zinc metalloprotease THERU_01235 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) THERU_01240 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) THERU_01255 ENOG4107QHF type ii secretion system protein e THERU_01290 ENOG4105CRQ synthase (Component I) THERU_01295 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) THERU_01300 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) THERU_01310 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) THERU_01315 ENOG4107ZTM Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) THERU_01330 ENOG4105DCI Phosphohydrolase THERU_01335 ENOG4105S3U THERU_01340 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) THERU_01345 ENOG4105CDV Ompa motb domain protein THERU_01350 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) THERU_01360 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) THERU_01370 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) THERU_01375 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) THERU_01380 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) THERU_01385 ENOG41061TZ Short-chain dehydrogenase reductase Sdr THERU_01390 ENOG4105BZU Histidine kinase THERU_01395 ENOG4105JE6 integral membrane protein THERU_01400 ENOG4108R0F Bacterial cellulose synthase subunit THERU_01415 ENOG41066HZ AIG2-like family THERU_01435 ENOG4105CFG Acts as a chaperone (By similarity) THERU_01440 ENOG4107YI3 Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) THERU_01445 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) THERU_01455 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits THERU_01460 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) THERU_01465 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) THERU_01470 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) THERU_01480 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) THERU_01485 ENOG4108C6F 50S ribosomal protein L30 THERU_01490 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) THERU_01495 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) THERU_01500 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) THERU_01505 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) THERU_01510 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) THERU_01520 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits THERU_01525 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) THERU_01530 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) THERU_01535 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) THERU_01540 ENOG4108ZT0 50S ribosomal protein l17 THERU_01545 ENOG4108VIA integral membrane protein THERU_01550 ENOG4105DX0 Hemolysin A THERU_01555 ENOG410615G THERU_01570 ENOG4105C3F Signal peptidase i THERU_01575 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs THERU_01585 ENOG4105CRK lysyL-tRNA synthetase THERU_01590 ENOG4108V3E phosphoribosylglycinamide formyltransferase THERU_01605 ENOG4105C8V SAICAR synthetase THERU_01610 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase THERU_01615 ENOG4105CPK Glycosyl transferase (Group 1 THERU_01630 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase THERU_01655 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) THERU_01660 ENOG4105HI1 THERU_01665 ENOG4108IYU L-aspartate oxidase THERU_01670 ENOG4105CHW UPF0052 protein THERU_01685 ENOG41081GI Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) THERU_01700 ENOG41063SB peptidase THERU_01715 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) THERU_01730 ENOG4105DTN riboflavin biosynthesis protein ribF THERU_01765 ENOG4108IAJ Nad-dependent epimerase dehydratase THERU_01770 ENOG41086UQ Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) THERU_01775 ENOG41082MB Involved in the transcription termination process (By similarity) THERU_01780 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) THERU_01785 ENOG4107QQT Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) THERU_01795 ENOG4105CUT histidyl-tRNA synthetase THERU_01805 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) THERU_01810 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) THERU_01815 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family THERU_01820 ENOG4105DC1 bifunctional purine biosynthesis protein purh THERU_01825 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I THERU_01830 ENOG4105VR9 phosphoribosylformylglycinamidine synthase THERU_01840 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) THERU_01865 ENOG4105CDU Replicative dna helicase THERU_01875 ENOG4105C01 Dihydroxy-acid dehydratase THERU_01880 ENOG4107R91 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) THERU_01890 ENOG4105VIE preprotein translocase, subunit YajC THERU_01895 ENOG4105CEY Amp-dependent synthetase and ligase THERU_01900 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) THERU_01905 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) THERU_01910 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) THERU_01950 ENOG4108HRK Histidine kinase THERU_01980 ENOG4105C59 p-type ATPase THERU_02015 ENOG4105M8K biopolymer transport protein THERU_02020 ENOG4105M15 transport protein ExbD THERU_02025 ENOG41067XB TonB family THERU_02040 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) THERU_02045 ENOG4105KTQ flagellar basal-body rod protein THERU_02050 ENOG4105C2M dna polymerase I THERU_02055 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) THERU_02060 ENOG4105K4P CoA-binding domain protein THERU_02065 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor THERU_02070 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) THERU_02075 ENOG41066RW THERU_02085 ENOG4105NAA Cytochrome C oxidase, subunit II THERU_02090 ENOG4107RQ2 Cytochrome c oxidase, subunit I THERU_02100 ENOG4105CZN Potassium uptake protein THERU_02105 ENOG4107ZYR domain protein THERU_02110 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) THERU_02120 ENOG4107VZ4 thymidylate synthase THERU_02125 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) THERU_02135 ENOG4105K6B K06886 hemoglobin THERU_02145 ENOG4105E33 succinate dehydrogenase THERU_02150 ENOG4108UKJ Cdp-alcohol phosphatidyltransferase THERU_02155 ENOG4105JVA Family of unknown function (DUF490) THERU_02170 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) THERU_02175 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) THERU_02190 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) THERU_02200 ENOG4105C22 threonyL-tRNA synthetase THERU_02210 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen THERU_02220 ENOG4105CKK Glycosyl transferase, family 2 THERU_02230 ENOG4105CHM Aminotransferase THERU_02235 ENOG4105NHS Transcriptional regulator, TraR DksA family THERU_02245 ENOG4105BZN citrate synthase THERU_02250 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) THERU_02255 ENOG4105Q33 Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency THERU_02265 ENOG4105CHM Aminotransferase THERU_02280 ENOG4108RWI nicotinamidase THERU_02285 ENOG4105K64 Glycosyl transferase, family 2 THERU_02290 ENOG4106M32 3-dehydroquinate synthase THERU_02295 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) THERU_02300 ENOG4105KJJ Uncharacterized ACR, COG1993 THERU_02305 ENOG4107N47 CrcB-like protein THERU_02310 ENOG4105KJJ Uncharacterized ACR, COG1993 THERU_02320 ENOG4105GKE subunit e THERU_02325 ENOG4107QIZ NADH dehydrogenase THERU_02330 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) THERU_02340 ENOG4105D4P Coproporphyrinogen iii oxidase THERU_02345 ENOG4108JQ7 (ABC) transporter THERU_02350 ENOG4108JU6 CBS domain protein THERU_02355 ENOG41085FC arsR family transcriptional regulator THERU_02370 ENOG4108UXE Protein tyrosine phosphatase THERU_02375 ENOG4107R5R arsenical pump membrane protein THERU_02380 ENOG41065BW THERU_02395 ENOG4107QI1 Mate efflux family protein THERU_02405 ENOG4107Y9E nuclease THERU_02410 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) THERU_02420 ENOG4105EW6 flavin reductase domain protein, FMN-binding THERU_02425 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) THERU_02430 ENOG4108Z1Z gCN5-related N-acetyltransferase THERU_02435 ENOG4107U9H DNA polymerase THERU_02440 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) THERU_02445 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) THERU_02450 ENOG4105C6Y Udp-glucose 6-dehydrogenase THERU_02455 ENOG4105C6T cysteine synthase THERU_02460 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) THERU_02465 ENOG4105C8S subunit m THERU_02475 ENOG4108373 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) THERU_02485 ENOG4107X8D NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) THERU_02490 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) THERU_02495 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) THERU_02500 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain THERU_02505 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) THERU_02510 ENOG4105C8S subunit m THERU_02520 ENOG410839Q NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) THERU_02530 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) THERU_02535 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) THERU_02540 ENOG4105VFF UPF0102 protein THERU_02545 ENOG4105VB6 UPF0109 protein THERU_02550 ENOG41085RT 30s ribosomal protein S16 THERU_02555 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) THERU_02560 ENOG4105CP7 Triose-phosphate isomerase THERU_02565 ENOG4105V2A permease YjgP YjgQ family protein THERU_02570 ENOG4105D52 delta-aminolevulinic acid dehydratase THERU_02575 ENOG4105CMV Succinyl-CoA synthetase subunit beta THERU_02580 ENOG4105SKE transcriptional Regulator LysR family THERU_02585 ENOG4105EM7 Selenocysteine-specific translation elongation factor THERU_02590 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) THERU_02595 ENOG4108KS2 transglutaminase domain protein THERU_02605 ENOG4105S6X Glycine cleavage THERU_02610 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) THERU_02615 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) THERU_02620 ENOG4108MG3 formate dehydrogenase THERU_02625 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein THERU_02630 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) THERU_02635 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) THERU_02645 ENOG41080S9 cina domain protein THERU_02650 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) THERU_02655 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) THERU_02660 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) THERU_02665 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) THERU_02670 ENOG4108Z1Z gCN5-related N-acetyltransferase THERU_02680 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) THERU_02685 ENOG4108K5P (LipO)protein THERU_02695 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate THERU_02700 ENOG4105VEQ Cold shock protein THERU_02720 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) THERU_02740 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) THERU_02745 ENOG4105CHM Aminotransferase THERU_02750 ENOG4105C8Y Acetylornithine aminotransferase THERU_02755 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) THERU_02765 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) THERU_02770 ENOG4105BZU Histidine kinase THERU_02775 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase THERU_02785 ENOG4107TRG DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) THERU_02790 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) THERU_02805 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase THERU_02810 ENOG4105C0P Mg chelatase subunit ChlI THERU_02815 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase THERU_02830 ENOG4105CDY transcriptional regulatory protein THERU_02835 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) THERU_02840 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) THERU_02850 ENOG4108ZAF Molybdopterin THERU_02855 ENOG4105HHA aminodeoxychorismate lyase THERU_02860 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) THERU_02875 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) THERU_02880 ENOG4107XPZ Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) THERU_02885 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) THERU_02900 ENOG4108KBH THERU_02910 ENOG4105DVY radical SAM domain protein THERU_02915 ENOG4105ES5 Histidine kinase THERU_02925 ENOG4108UFN THERU_02950 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) THERU_02955 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) THERU_02960 ENOG4105CSA Coproporphyrinogen iii oxidase THERU_02965 ENOG4105CNI cell division protein FtsW THERU_02975 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) THERU_02985 ENOG4105CZX twitching motility protein THERU_02990 ENOG4105D7Q type ii secretion system THERU_02995 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) THERU_03010 ENOG4105ECC imidazole-glycerol-phosphate dehydratase THERU_03015 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain THERU_03020 ENOG4105WCJ ec 1.1.1.193 THERU_03030 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase THERU_03035 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) THERU_03065 ENOG4105DBV ornithine carbamoyltransferase THERU_03075 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) THERU_03085 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) THERU_03095 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) THERU_03105 ENOG4105C5T Phosphoribosyl pyrophosphate synthase THERU_03110 ENOG4107ZTA This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) THERU_03115 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) THERU_03125 ENOG4105C98 muts2 protein THERU_03130 ENOG4108JIR Flagellum-specific ATP synthase THERU_03145 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) THERU_03150 ENOG4105E2Z phosphate ABC transporter (Permease THERU_03155 ENOG4105C8U phosphate abc transporter THERU_03160 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) THERU_03170 ENOG4105D60 lipoprotein releasing system transmembrane protein THERU_03175 ENOG4107KET secretion protein, HlyD family THERU_03180 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH THERU_03185 ENOG41061GT Aldolase THERU_03195 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) THERU_03210 ENOG4105FF2 Type I DHQase THERU_03215 ENOG4105CDH Citrulline--aspartate ligase THERU_03220 ENOG4105CBC glutamate synthase THERU_03225 ENOG4108RIR Molybdenum cofactor biosynthesis protein THERU_03235 ENOG4105CFH Aspartokinase THERU_03245 ENOG4105Q81 Ferredoxin THERU_03250 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) THERU_03255 ENOG4107SH3 glycosyl transferase, family 39 THERU_03265 ENOG4108ZP8 Acetolactate synthase small subunit THERU_03270 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) THERU_03275 ENOG4108KAG Cytochrome C oxidase, subunit I THERU_03280 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) THERU_03300 ENOG4105DDK oxidoreductase, beta subunit THERU_03315 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) THERU_03320 ENOG4105C34 Pseudouridine synthase THERU_03330 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis THERU_03335 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) THERU_03340 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) THERU_03350 ENOG4105D48 metallophosphoesterase THERU_03355 ENOG4105CHR reductase THERU_03360 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) THERU_03370 ENOG41083MZ Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) THERU_03375 ENOG4108ZC9 flagellar basal-body rod protein flgc THERU_03380 ENOG41086ME flagellar hook-basal body complex THERU_03390 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) THERU_03395 ENOG4105DCG PHP domain protein THERU_03410 ENOG4105K8N protein family UPF0079, ATPase THERU_03415 ENOG4105PGM cation diffusion facilitator family transporter THERU_03420 ENOG4105N5T Radical SAM Protein THERU_03435 ENOG4107GFK fumarate THERU_03445 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) THERU_03455 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) THERU_03470 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) THERU_03475 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) THERU_03485 ENOG4106VK6 Flagellar motor protein THERU_03500 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) THERU_03510 ENOG4108UXE Protein tyrosine phosphatase THERU_03520 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY THERU_03545 ENOG4108P3C THERU_03555 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate THERU_03560 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) THERU_03575 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase THERU_03580 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) THERU_03590 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) THERU_03605 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) THERU_03610 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) THERU_03615 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) THERU_03635 ENOG4105EJ9 Membrane THERU_03650 ENOG4105DSJ YicC domain protein THERU_03660 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) THERU_03665 ENOG4105SZ0 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) THERU_03670 ENOG4105MWA Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) THERU_03680 ENOG4108YZG isomerase THERU_03685 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) THERU_03700 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) THERU_03705 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) THERU_03725 ENOG4105CE1 Ferrous iron transport protein b THERU_03735 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) THERU_03745 ENOG4105CH7 arginosuccinase THERU_03755 ENOG41083S1 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) THERU_03760 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase THERU_03765 ENOG4105C8J )-transporter THERU_03780 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) THERU_03785 ENOG4105E0C molybdate abc transporter THERU_03800 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) THERU_03815 ENOG4105II7 pyrroline-5-carboxylate reductase THERU_03820 ENOG41083W3 Multi-copper polyphenol oxidoreductase laccase THERU_03840 ENOG4105DK0 Indole-3-glycerol phosphate synthase THERU_03845 ENOG4107XUC SirA family THERU_03860 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) THERU_03875 ENOG4105VXP Protein of unknown function DUF86 THERU_03890 ENOG4105VXP Protein of unknown function DUF86 THERU_03920 ENOG4105C0D helicase THERU_03925 ENOG4105F8V Hydrolase, tatD family THERU_03935 ENOG4107QSA Oxaloacetate decarboxylase THERU_03940 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase THERU_03955 ENOG4108Z6B deaminase THERU_03970 ENOG410845P Methylates ribosomal protein L11 (By similarity) THERU_03975 ENOG4105CSM endonuclease III THERU_03980 ENOG4105CQB FAD linked oxidase domain protein THERU_03995 ENOG4108X4A THERU_04020 ENOG4105CAQ asparagine synthetase THERU_04025 ENOG4105CG5 Glycosyl transferase (Group 1 THERU_04030 ENOG4105K64 Glycosyl transferase, family 2 THERU_04035 ENOG4107QQG Dehydrogenase THERU_04080 ENOG4105ESV Glycosyl transferase, family 4 THERU_04090 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) THERU_04105 ENOG4105BZU Histidine kinase THERU_04120 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) THERU_04125 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving THERU_04135 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) THERU_04140 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) THERU_04150 ENOG4108SJC Membrane THERU_04155 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division THERU_04160 ENOG41090R7 Ferric uptake THERU_04165 ENOG4107QZT geranylgeranyl reductase THERU_04170 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) THERU_04185 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase THERU_04190 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) THERU_04195 ENOG4105UGY THERU_04200 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) THERU_04210 ENOG4105D00 flagellar biosynthetic protein flhB THERU_04220 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) THERU_04230 ENOG4105D7N magnesium and cobalt transport protein CorA THERU_04245 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) THERU_04255 ENOG4105DKP glycosyl transferase, family 9 THERU_04260 ENOG41061D6 THERU_04270 ENOG4105DVT helicase THERU_04275 ENOG4107YU2 histidine triad (hIT) protein THERU_04280 ENOG4108Z03 MAF-like protein THERU_04285 ENOG4107RDB Major Facilitator THERU_04295 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) THERU_04300 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) THERU_04310 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) THERU_04320 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) THERU_04330 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit THERU_04435 ENOG41070QX THERU_04450 ENOG4108QCZ crispr-associated cxxc_cxxc protein cst1 THERU_04455 ENOG4105DTT CRISPR-associated helicase, cas3 THERU_04465 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) THERU_04470 ENOG4105ZHF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) THERU_04495 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) THERU_04500 ENOG4107QHF type ii secretion system protein e THERU_04505 ENOG41082UD thioesterase Superfamily protein THERU_04515 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) THERU_04525 ENOG4105CY3 ABC transporter, permease THERU_04530 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase THERU_04535 ENOG41085S9 50S ribosomal protein l28 THERU_04560 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) THERU_04570 ENOG4108TTH THERU_04575 ENOG4105C3G gtp-binding protein THERU_04595 ENOG4105BZU Histidine kinase THERU_04600 ENOG4108ZYE Transcriptional regulator THERU_04605 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) THERU_04615 ENOG4105BZU Histidine kinase THERU_04630 ENOG4108K28 Arsenite oxidase, large subunit THERU_04645 ENOG4107QN2 dihydrolipoyl dehydrogenase THERU_04650 ENOG4108IFG nitrite reductase, (NAD(P)H) THERU_04655 ENOG4105I5W Transporter THERU_04670 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) THERU_04680 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) THERU_04695 ENOG4105UUH Domain of unknown function DUF302 THERU_04700 ENOG4105CGH 5'-nucleotidase THERU_04705 ENOG4108XRS Monoheme cytochrome SoxX (Sulfur oxidation) THERU_04740 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP THERU_04750 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) THERU_04760 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase THERU_04775 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein THERU_04785 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) THERU_04790 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) THERU_04795 ENOG4105WRB Hydrogenase assembly chaperone hypC hupF THERU_04805 ENOG4105F71 Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) THERU_04815 ENOG4108JJB ABC transporter THERU_04825 ENOG4105G01 cobalamin (vitamin B12) biosynthesis CbiM protein THERU_04845 ENOG4105MRR Transcriptional regulator (By similarity) THERU_04850 ENOG4105E3S small subunit THERU_04855 ENOG4105DPX Hydrogenase, large subunit THERU_04865 ENOG4108USZ hydrogenase THERU_04870 ENOG4108UT5 Hydrogenase expression THERU_04880 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) THERU_04890 ENOG4105DPX Hydrogenase, large subunit THERU_04895 ENOG4105E3S small subunit THERU_04965 ENOG4105DC8 reductase THERU_04970 ENOG4107RIQ Sulfate adenylate transferase THERU_04975 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) THERU_05000 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family THERU_05065 ENOG4107QJE Chromosome Partitioning Protein THERU_05085 ENOG4105C7R Atpase associated with various cellular activities aaa_3 THERU_05090 ENOG4108JEB The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) THERU_05095 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) THERU_05100 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) THERU_05150 ENOG41066HZ AIG2-like family THERU_05175 ENOG4105C3M thioredoxin reductase THERU_05185 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) THERU_05200 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) THERU_05215 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) THERU_05225 ENOG4105FE9 pseudouridine synthase THERU_05235 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase THERU_05240 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) THERU_05245 ENOG4105DFU Cell wall formation (By similarity) THERU_05280 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) THERU_05285 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) THERU_05295 ENOG4107RFA Glycyl-tRNA synthetase beta subunit THERU_05300 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) THERU_05325 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) THERU_05330 ENOG4105KSK (crossover) junction endodeoxyribonuclease THERU_05335 ENOG4107X35 defense response to bacterium THERU_05340 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 THERU_05345 ENOG4105CJ2 (LipO)protein THERU_05350 ENOG4105J9Q THERU_05360 ENOG41079HR Phosphate-Selective Porin O and P THERU_05365 ENOG41082J7 Rhodanese domain protein THERU_05370 ENOG4105C7Z Conserved Protein THERU_05375 ENOG4105C83 adenylosuccinate lyase THERU_05380 ENOG4105DWF phosphomethylpyrimidine kinase THERU_05390 ENOG4105KME endoribonuclease L-psp THERU_05395 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit THERU_05400 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) THERU_05405 ENOG410666C THERU_05410 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) THERU_05415 ENOG4105C4K Nad synthetase THERU_05420 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) THERU_05430 ENOG4108RAC Rubrerythrin THERU_05445 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase THERU_05450 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) THERU_05455 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) THERU_05460 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) THERU_05475 ENOG4105C75 arginyL-tRNA synthetase THERU_05480 ENOG4107QNG Phosphoribosylglycinamide synthetase THERU_05485 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase THERU_05495 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) THERU_05500 ENOG4107QI6 Cysteine desulfurase THERU_05505 ENOG4105D1F ATP-binding protein THERU_05515 ENOG4105EAH synthase THERU_05540 ENOG4105DHP deoxycytidine triphosphate deaminase THERU_05560 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) THERU_05565 ENOG4105CXV gliding motility protein THERU_05575 ENOG4105CK6 Two component transcriptional regulator (Winged helix family THERU_05590 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) THERU_05595 ENOG4108UB3 Thiamine monophosphate THERU_05615 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) THERU_05620 ENOG4105BZ9 Cytochrome C oxidase, subunit I THERU_05630 ENOG4105CE9 30S ribosomal protein S2 THERU_05635 ENOG41082NI Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ THERU_05645 ENOG41086YC UPF0235 protein THERU_05650 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) THERU_05655 ENOG4105C8N cysteinyl-tRNA synthetase THERU_05660 ENOG4105CVM Molybdenum cofactor synthesis domain protein THERU_05665 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) THERU_05670 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) THERU_05675 ENOG4105BZU Histidine kinase THERU_05680 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) THERU_05685 ENOG4108ZAI phosphatidylglycerophosphatase a THERU_05690 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) THERU_05705 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation THERU_05710 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) THERU_05715 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) THERU_05725 ENOG4105K6T rare lipoprotein A THERU_05730 ENOG4105CG5 Glycosyl transferase (Group 1 THERU_05775 ENOG4105KHS type IV fimbrial pilin protein THERU_05790 ENOG4105C2N RNA methyltransferase TrmH family group 3 THERU_05795 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) THERU_05800 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) THERU_05820 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) THERU_05825 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) THERU_05850 ENOG4108JUA Transcriptional regulator THERU_05860 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) THERU_05870 ENOG41083CN Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) THERU_05880 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain THERU_05925 ENOG4107T8Q Glycosyl transferase (Group 1 THERU_05945 ENOG4105C8T Leucyl-tRNA synthetase THERU_05950 ENOG4107RIU May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins (By similarity) THERU_05955 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) THERU_05960 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) THERU_05975 ENOG4105E2X shikimate dehydrogenase THERU_05980 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) THERU_05985 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase THERU_05990 ENOG4105BZU Histidine kinase THERU_05995 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) THERU_06005 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase THERU_06015 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase THERU_06020 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) THERU_06025 ENOG4107V5B Major Facilitator THERU_06035 ENOG4108T9Q UPF0278 protein THERU_06040 ENOG4108YX9 iron--sulfur cluster insertion protein erpA THERU_06050 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase THERU_06060 ENOG4105XJC Two component transcriptional regulator (Winged helix family THERU_06065 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) THERU_06070 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) THERU_06075 ENOG4105E63 Pfam:DUF178 THERU_06090 ENOG4105M15 transport protein ExbD THERU_06095 ENOG4105M8K biopolymer transport protein THERU_06110 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) THERU_06115 ENOG4105CD3 dihydroorotase THERU_06120 ENOG4108JQC penicillin-binding protein 1A THERU_06125 ENOG4108Z0R Transferase THERU_06135 ENOG4105TKY THERU_06140 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) THERU_06145 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) THERU_06150 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) THERU_06160 ENOG4105CJR Integral membrane protein (MviN THERU_06165 ENOG41082E4 Binds directly to 16S ribosomal RNA (By similarity) THERU_06170 ENOG4105W2Z cytochrome C, class I THERU_06175 ENOG4107SA8 fad-dependent pyridine nucleotide-disulfide oxidoreductase THERU_06190 ENOG4105CPQ Dehydrogenase THERU_06195 ENOG4106TD9 Diguanylate cyclase THERU_06200 ENOG4105D4A Cell wall formation (By similarity) THERU_06205 ENOG4105CPF Cell wall formation (By similarity) THERU_06215 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) THERU_06220 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) THERU_06235 ENOG4107YZX Universal stress protein THERU_06240 ENOG4105ECY inositol monophosphatase THERU_06245 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) THERU_06250 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) THERU_06255 ENOG4108UJD 30S ribosomal protein S9 THERU_06260 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase THERU_06270 ENOG4108UJG THERU_06285 ENOG4105C59 p-type ATPase THERU_06290 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) THERU_06295 ENOG41085CK 50S ribosomal protein L35 THERU_06325 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) THERU_06330 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) THERU_06335 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) THERU_06360 ENOG4105CVJ phosphoglycerate mutase THERU_06365 ENOG4105C5R Aminotransferase THERU_06370 ENOG4105CZA synthase THERU_06380 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) THERU_06385 ENOG4105GRF N-glycosylase DNA lyase THERU_06390 ENOG4105D0U Arsenite-activated ATPase (ArsA) THERU_06400 ENOG4105W2Z cytochrome C, class I THERU_06405 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) THERU_06410 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) THERU_06445 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain THERU_06450 ENOG4105CJN penicillin-binding protein THERU_06455 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) THERU_06460 ENOG4105D07 Signal peptide peptidase, SppA THERU_06470 ENOG4108VAU general secretion pathway protein G THERU_06485 ENOG4105D7Q type ii secretion system THERU_06495 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) THERU_06500 ENOG4107RXH tRNA synthetase valyl leucyl anticodon-binding THERU_06515 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) THERU_06520 ENOG4105DDK oxidoreductase, beta subunit THERU_06540 ENOG4105D65 subunit l THERU_06545 ENOG4105EVH UPF0753 protein THERU_06565 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) THERU_06570 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) THERU_06575 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) THERU_06585 ENOG4108QU6 THERU_06595 ENOG4105SYT Methylenetetrahydrofolate reductase THERU_06605 ENOG41067KJ GYD family THERU_06630 ENOG4105CMV Succinyl-CoA synthetase subunit beta THERU_06635 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha THERU_06640 ENOG4108KDI dmso reductase anchor subunit THERU_06645 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein THERU_06660 ENOG4105DB1 molybdopterin oxidoreductase THERU_06690 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha THERU_06710 ENOG4105CSM endonuclease III THERU_06725 ENOG41083NF Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) THERU_06750 ENOG4107QN1 sodium solute THERU_06760 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) THERU_06800 ENOG4105FTC Lytic transglycosylase catalytic THERU_06805 ENOG4108R6K riboflavin synthase, subunit alpha THERU_06810 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) THERU_06815 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component THERU_06825 ENOG4105ECR NmrA family THERU_06830 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) THERU_06845 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) THERU_06850 ENOG4105BZE flagellar hook protein, FlgE THERU_06865 ENOG4108JVH Protein of unknown function DUF43 THERU_06870 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) THERU_06875 ENOG4107NFR Fructose-1,6-bisphosphatase THERU_06885 ENOG4106K5Q Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity) THERU_06895 ENOG4108UKJ Cdp-alcohol phosphatidyltransferase THERU_06900 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) THERU_06905 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) THERU_06915 ENOG4108UGV hypoxanthine phosphoribosyltransferase THERU_06920 ENOG4105DXN mazG family THERU_06925 ENOG4105C9M aspartyl-trna synthetase THERU_06930 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) THERU_06940 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) THERU_06950 ENOG4105DFA alanine racemase domain protein THERU_06955 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation THERU_06960 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) THERU_06965 ENOG4105C4B ABC transporter, permease THERU_06970 ENOG4107QIK phosphoribosylformylglycinamidine synthase THERU_06975 ENOG4108386 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) THERU_06995 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) THERU_07000 ENOG41079KZ Major Facilitator Superfamily THERU_07010 ENOG4105CIZ coA-substrate-specific enzyme activase THERU_07020 ENOG4105V6R THERU_07025 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) THERU_07030 ENOG4105BZA Phosphoglycerate kinase THERU_07035 ENOG41065IR THERU_07040 ENOG4108JUA Transcriptional regulator THERU_07045 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) THERU_07050 ENOG4105U0R haloacid dehalogenase-like hydrolase THERU_07060 ENOG4105BZU Histidine kinase THERU_07065 ENOG4105C5F glutamine synthetase THERU_07070 ENOG4108YZA Nitrogen regulatory protein pii THERU_07080 ENOG4107YIW Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) THERU_07085 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) THERU_07095 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) THERU_07100 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor THERU_07110 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) THERU_07115 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) THERU_07120 ENOG4105C5X domain protein THERU_07125 ENOG4106WTF Glycosyl transferase, family 2 THERU_07135 ENOG4107GFK fumarate THERU_07145 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) THERU_07150 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) THERU_07160 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) THERU_07165 ENOG4105K46 50S ribosomal protein l27 THERU_07170 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) THERU_07180 ENOG4105C5I Dehydrogenase THERU_07185 ENOG4105BZ8 glutamate synthase THERU_07190 ENOG4105MPX THERU_07200 ENOG4105CNI cell division protein FtsW THERU_07205 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase THERU_07210 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) THERU_07220 ENOG4105C2X Arabinose 5-phosphate isomerase THERU_07250 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) THERU_07255 ENOG4105WDJ 50S ribosomal protein L33 THERU_07265 ENOG41062BN Preprotein translocase SecE subunit THERU_07270 ENOG4107WP1 Participates in transcription elongation, termination and antitermination (By similarity) THERU_07275 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) THERU_07280 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) THERU_07285 ENOG410823K 50S ribosomal protein L10 THERU_07290 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) THERU_07300 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) THERU_07305 ENOG4107QR0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) THERU_07310 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) THERU_07315 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) THERU_07320 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) THERU_07325 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) THERU_07330 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) THERU_07335 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) THERU_07340 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) THERU_07345 ENOG41082UH One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) THERU_07350 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity THERU_07355 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) THERU_07360 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) THERU_07365 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) THERU_07370 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) THERU_07375 ENOG4107FF9 50s ribosomal protein l29 THERU_07380 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal THERU_07395 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) THERU_07400 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit THERU_07405 ENOG4107SBB 4-alpha-glucanotransferase (EC 2.4.1.25) THERU_07420 ENOG4108IUZ ABC transporter THERU_07425 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) THERU_07430 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) THERU_07435 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) THERU_07460 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) THERU_07465 ENOG4105D06 uba thif-type nad fad binding protein THERU_07470 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) THERU_07480 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) THERU_07485 ENOG4108UR0 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) THERU_07490 ENOG4105K6T rare lipoprotein A THERU_07495 ENOG4105EVD ribosomal RNA large subunit methyltransferase N THERU_07500 ENOG4105MA4 psp1 domain protein THERU_07505 ENOG4107QRG dna polymerase iii THERU_07510 ENOG4105EUJ GTP cyclohydrolase i THERU_07515 ENOG4105CV1 Transketolase (EC 2.2.1.1) THERU_07520 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) THERU_07525 ENOG4105C9A Phoh family THERU_07530 ENOG4105CXT aspartate transcarbamylase THERU_07545 ENOG4105C6E dna polymerase iii THERU_07550 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) THERU_07565 ENOG4105CIH Imidazole acetol-phosphate transaminase THERU_07575 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) THERU_07580 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase THERU_07585 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) THERU_07590 ENOG4108JB8 alcohol dehydrogenase THERU_07595 ENOG4105NHS Transcriptional regulator, TraR DksA family THERU_07600 ENOG41085K0 50S ribosomal protein L31 THERU_07605 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) THERU_07610 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) THERU_07615 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) THERU_07630 ENOG4108RKS Short-chain dehydrogenase reductase Sdr THERU_07645 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) THERU_07655 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) THERU_07665 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) THERU_07680 ENOG4107ZS6 Flavodoxin THERU_07685 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) THERU_07690 ENOG4105CHV Transcription elongation factor NusA THERU_07695 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) THERU_07705 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) THERU_07720 ENOG4107S0N DJ-1 family THERU_07725 ENOG4105DR4 Methyltransferase THERU_07730 ENOG4105BZ1 (ABC) transporter THERU_07735 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) THERU_07745 ENOG4105R8R Ferredoxin THERU_07750 ENOG4105CHM Aminotransferase THERU_07755 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) THERU_07775 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase THERU_07780 ENOG4105DHJ ABC, transporter THERU_07790 ENOG4107QYG anthranilate phosphoribosyltransferase THERU_07800 ENOG4105RRV Inherit from COG: copper resistance THERU_07815 ENOG4105CM2 brancheD-chain amino acid aminotransferase THERU_07820 ENOG41067VY 50S ribosomal protein L32 THERU_07825 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) THERU_07830 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) THERU_07835 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) THERU_07845 ENOG4105ENT Efflux transporter rnd family, mfp subunit THERU_07860 ENOG4105CRE cytochrome C THERU_07865 ENOG4105K9Q Binds to the 23S rRNA (By similarity) THERU_07870 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) THERU_07875 ENOG41082Y9 Single-strand binding protein THERU_07880 ENOG41083NI Binds together with S18 to 16S ribosomal RNA (By similarity) THERU_07885 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase THERU_07895 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) THERU_07900 ENOG4105CS7 Catalyzes the conversion of dihydroorotate to orotate THERU_07915 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) THERU_07920 ENOG4105CY0 Metallo-Beta-Lactamase THERU_07925 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) THERU_07930 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) THERU_07935 ENOG4105DIN metallophosphoesterase THERU_07940 ENOG4105CK6 Two component transcriptional regulator (Winged helix family THERU_07945 ENOG4107QSA Oxaloacetate decarboxylase THERU_07950 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) THERU_07955 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein THERU_07965 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) THERU_07970 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) THERU_07975 ENOG4105C0H protease THERU_07980 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) THERU_07985 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) THERU_08000 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) THERU_08005 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) THERU_08020 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) THERU_08025 ENOG4105CAS nag kinase THERU_08045 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) THERU_08050 ENOG4108412 folate-binding protein ygfz THERU_08055 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase THERU_08065 ENOG4108K3F N(2),N(2)-dimethylguanosine tRNA methyltransferase THERU_08070 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) THERU_08100 ENOG4107XN1 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) THERU_08110 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) THERU_08120 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) THERU_08125 ENOG4105C1Q protoporphyrinogen oxidase THERU_08130 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) THERU_08150 ENOG4105DC7 peptidase M24 THERU_08160 ENOG4105C8B TIGR00159 family THERU_08170 ENOG4107X8G Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) THERU_08180 ENOG41074MP UPF0103 Mediator of ErbB2-driven cell motility-containing protein THERU_08190 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) THERU_08200 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase THERU_08205 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) THERU_08210 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) THERU_08215 ENOG4107TT5 NLP P60 protein THERU_08220 ENOG4108VTU Cdp-alcohol phosphatidyltransferase THERU_08235 ENOG4108ZCD Transcriptional coactivator pterin dehydratase THERU_08255 ENOG4105D00 flagellar biosynthetic protein flhB THERU_08260 ENOG4105D19 Role in flagellar biosynthesis (By similarity) THERU_08265 ENOG4105VS8 Flagellar biosynthetic protein fliq THERU_08270 ENOG4105CN7 Flagellar biosynthetic protein FliP THERU_08280 ENOG4105X6C Flagellar basal body-associated protein FliL THERU_08285 ENOG4105CMS peptidase U62, modulator of DNA gyrase THERU_08295 ENOG4105FV0 THERU_08300 ENOG4107QRA Extracellular solute-binding protein, family 5 THERU_08305 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) THERU_08310 ENOG4105CRQ synthase (Component I) THERU_08315 ENOG4108UVJ appr-1-p processing domain protein THERU_08320 ENOG4105D7B Flagellar biosynthesis protein flha THERU_08325 ENOG4105FZW flagellar biosynthesis regulator FlhF THERU_08335 ENOG4108WTY tRNA (Guanine-N(1)-)-methyltransferase THERU_08340 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) THERU_08345 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) THERU_08350 ENOG4105CTB Polyprenyl synthetase THERU_08355 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) THERU_08365 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein THERU_08370 ENOG4105ERG peptidase m48, ste24p THERU_08380 ENOG4108215 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) THERU_08400 ENOG41067WS THERU_08410 ENOG4107KIA Virulence factor Mce family protein THERU_08420 ENOG4105IJJ transcriptional regulator, crp fnr family THERU_08425 ENOG4105MS2 ribosomal subunit Interface protein THERU_08430 ENOG4105GB4 17 kDa surface antigen THERU_08435 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) THERU_08440 ENOG4108HMX isocitrate dehydrogenase (NADP) THERU_08445 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) THERU_08450 ENOG4105DSE periplasmic solute binding protein THERU_08455 ENOG4105FDK ABC transporter THERU_08460 ENOG4105CC5 ABC transporter THERU_08465 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase THERU_08475 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) THERU_08480 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control THERU_08485 ENOG4105CSM endonuclease III THERU_08500 ENOG4105CPC Aldo Keto reductase