locus-tag	class	description
Thein_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Thein_0002	COG0277	FAD linked oxidase domain protein
Thein_0003	COG4771	TonB-dependent receptor
Thein_0005	COG3852	Histidine kinase
Thein_0006	COG0129	dihydroxy-acid dehydratase activity
Thein_0007	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Thein_0008	COG1758	RNA polymerase activity
Thein_0009	COG0484	heat shock protein binding
Thein_0010	COG0315	cyclic pyranopterin monophosphate synthase activity
Thein_0011	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Thein_0016	COG2204	response regulator
Thein_0018	COG1530	ribonuclease E activity
Thein_0024	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Thein_0024	COG0574	Belongs to the PEP-utilizing enzyme family
Thein_0028	COG0156	8-amino-7-oxononanoate synthase activity
Thein_0031	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Thein_0033	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Thein_0035	COG0358	DNA primase activity
Thein_0036	COG1193	negative regulation of DNA recombination
Thein_0037	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Thein_0038	COG0009	L-threonylcarbamoyladenylate synthase
Thein_0040	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Thein_0040	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Thein_0042	COG2226	methyltransferase
Thein_0043	COG0436	Aminotransferase
Thein_0044	COG2715	membrane protein required for spore maturation
Thein_0045	COG1691	(AIR) carboxylase
Thein_0047	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Thein_0048	COG0475	glutathione-regulated potassium exporter activity
Thein_0048	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Thein_0049	COG0166	Belongs to the GPI family
Thein_0055	COG0425	Belongs to the sulfur carrier protein TusA family
Thein_0060	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Thein_0064	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Thein_0065	COG1785	Belongs to the alkaline phosphatase family
Thein_0070	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Thein_0073	COG1285	pathogenesis
Thein_0074	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Thein_0076	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
Thein_0077	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Thein_0078	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Thein_0079	COG2204	response regulator
Thein_0083	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Thein_0083	COG1519	Transferase
Thein_0084	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Thein_0085	COG0194	GDP metabolic process
Thein_0086	COG2052	Domain of unknown function (DUF370)
Thein_0087	COG1561	YicC-like family, N-terminal region
Thein_0089	COG2885	chlorophyll binding
Thein_0091	COG0837	glucose binding
Thein_0093	COG0728	peptidoglycan biosynthetic process
Thein_0098	COG0735	belongs to the Fur family
Thein_0100	COG0840	transmembrane signaling receptor activity
Thein_0101	COG0612	Peptidase, M16
Thein_0102	COG0489	protein tyrosine kinase activity
Thein_0104	COG0247	lactate metabolic process
Thein_0106	COG1397	ADP-ribosylglycohydrolase
Thein_0108	COG4106	trans-aconitate 2-methyltransferase activity
Thein_0114	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Thein_0116	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Thein_0117	COG1214	PFAM Peptidase M22, glycoprotease
Thein_0118	COG0601	transmembrane transport
Thein_0119	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Thein_0120	COG0071	Belongs to the small heat shock protein (HSP20) family
Thein_0121	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Thein_0124	COG1328	CTP reductase activity
Thein_0124	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Thein_0125	COG0803	Belongs to the bacterial solute-binding protein 9 family
Thein_0126	COG1213	nucleotidyl transferase
Thein_0126	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Thein_0128	COG4191	Histidine kinase
Thein_0129	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Thein_0130	COG0509	glycine decarboxylation via glycine cleavage system
Thein_0131	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Thein_0133	COG2835	tetraacyldisaccharide 4'-kinase activity
Thein_0136	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Thein_0138	COG1309	transcriptional regulator
Thein_0142	COG0019	diaminopimelate decarboxylase activity
Thein_0143	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Thein_0146	COG0616	signal peptide processing
Thein_0147	COG0248	Ppx GppA phosphatase
Thein_0148	COG0516	GMP reductase activity
Thein_0148	COG0517	IMP dehydrogenase activity
Thein_0151	COG0484	heat shock protein binding
Thein_0152	COG1519	Transferase
Thein_0152	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Thein_0153	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Thein_0154	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Thein_0156	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Thein_0157	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Thein_0165	COG0789	Transcriptional regulator
Thein_0169	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Thein_0170	COG1067	ATP-dependent peptidase activity
Thein_0173	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Thein_0174	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Thein_0175	COG0163	prenyltransferase activity
Thein_0177	COG1648	precorrin-2 dehydrogenase activity
Thein_0177	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Thein_0179	COG1580	Controls the rotational direction of flagella during chemotaxis
Thein_0183	COG1338	Plays a role in the flagellum-specific transport system
Thein_0184	COG1987	bacterial-type flagellum assembly
Thein_0185	COG1684	flagellar biosynthetic protein fliR
Thein_0186	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Thein_0187	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Thein_0188	COG1419	protein localization to endoplasmic reticulum
Thein_0189	COG0455	bacterial-type flagellum organization
Thein_0190	COG1191	sigma factor activity
Thein_0197	COG1959	2 iron, 2 sulfur cluster binding
Thein_0199	COG1047	Peptidyl-prolyl cis-trans
Thein_0200	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
Thein_0202	COG0004	ammonium transporteR
Thein_0203	COG0347	Belongs to the P(II) protein family
Thein_0207	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Thein_0208	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Thein_0209	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Thein_0211	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Thein_0211	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Thein_0213	COG0195	Participates in both transcription termination and antitermination
Thein_0214	COG0779	Required for maturation of 30S ribosomal subunits
Thein_0229	COG1203	CRISPR-associated helicase, Cas3
Thein_0232	COG1518	maintenance of DNA repeat elements
Thein_0233	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Thein_0236	COG0730	response to heat
Thein_0243	COG0557	exoribonuclease II activity
Thein_0245	COG0537	adenosine 5'-monophosphoramidase activity
Thein_0248	COG0242	peptide deformylase activity
Thein_0253	COG0473	3-isopropylmalate dehydrogenase activity
Thein_0254	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Thein_0257	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Thein_0260	COG3852	Histidine kinase
Thein_0262	COG1181	Belongs to the D-alanine--D-alanine ligase family
Thein_0264	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Thein_0265	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Thein_0266	COG1515	deoxyribonuclease V activity
Thein_0267	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Thein_0270	COG0455	bacterial-type flagellum organization
Thein_0271	COG3706	GGDEF domain
Thein_0271	COG0745	RESPONSE REGULATOR receiver
Thein_0273	COG0085	RNA polymerase activity
Thein_0274	COG0222	ribosome binding
Thein_0275	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Thein_0277	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Thein_0280	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Thein_0281	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Thein_0284	COG1233	COG1233 Phytoene dehydrogenase and related
Thein_0287	COG0746	molybdenum cofactor guanylyltransferase activity
Thein_0289	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
Thein_0290	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
Thein_0292	COG0298	carbon dioxide binding
Thein_0293	COG0375	protein maturation
Thein_0295	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Thein_0296	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Thein_0297	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Thein_0298	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Thein_0302	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Thein_0303	COG0527	aspartate kinase activity
Thein_0304	COG0484	heat shock protein binding
Thein_0312	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Thein_0314	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Thein_0315	COG0840	transmembrane signaling receptor activity
Thein_0316	COG1910	domain protein
Thein_0317	COG2998	abc-type tungstate transport system, permease component
Thein_0318	COG4662	Binding-protein-dependent transport system inner membrane component
Thein_0322	COG2204	response regulator
Thein_0323	COG4191	Histidine kinase
Thein_0327	COG0589	response to stress
Thein_0331	COG0589	response to stress
Thein_0333	COG0589	response to stress
Thein_0334	COG1227	inorganic diphosphatase activity
Thein_0340	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Thein_0341	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Thein_0342	COG2199	diguanylate cyclase activity
Thein_0345	COG0835	chemotaxis
Thein_0346	COG0484	heat shock protein binding
Thein_0347	COG0643	Histidine kinase
Thein_0347	COG2198	Histidine kinase
Thein_0348	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Thein_0349	COG2201	protein-glutamate methylesterase activity
Thein_0351	COG0736	holo-[acyl-carrier-protein] synthase activity
Thein_0352	COG0857	belongs to the CobB CobQ family
Thein_0353	COG1042	CoA-binding domain protein
Thein_0353	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Thein_0353	COG0045	succinate-CoA ligase (ADP-forming) activity
Thein_0360	COG0710	3-dehydroquinate dehydratase activity
Thein_0362	COG0535	radical SAM domain protein
Thein_0363	COG0784	Response regulator, receiver
Thein_0364	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Thein_0365	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Thein_0366	COG0084	hydrolase, TatD family'
Thein_0370	COG0823	Involved in the tonB-independent uptake of proteins
Thein_0371	COG1960	acyl-CoA dehydrogenase activity
Thein_0372	COG2086	electron transfer activity
Thein_0373	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Thein_0375	COG1028	Short-chain dehydrogenase reductase Sdr
Thein_0379	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Thein_0380	COG0698	ribose 5-phosphate isomerase
Thein_0381	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Thein_0382	COG2131	deaminase
Thein_0384	COG0765	amino acid transport
Thein_0386	COG1794	racemase activity, acting on amino acids and derivatives
Thein_0387	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Thein_0389	COG0288	reversible hydration of carbon dioxide
Thein_0395	COG5002	protein histidine kinase activity
Thein_0396	COG0745	RESPONSE REGULATOR receiver
Thein_0397	COG0307	riboflavin synthase, alpha
Thein_0398	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Thein_0404	COG2221	Nitrite and sulphite reductase 4Fe-4S
Thein_0405	COG2221	Nitrite and sulphite reductase 4Fe-4S
Thein_0408	COG1100	Small GTP-binding protein
Thein_0410	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Thein_0411	COG5002	protein histidine kinase activity
Thein_0415	COG2855	membrane
Thein_0417	COG1234	tRNA 3'-trailer cleavage
Thein_0429	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Thein_0432	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Thein_0433	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Thein_0434	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Thein_0435	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Thein_0436	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Thein_0437	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Thein_0438	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Thein_0441	COG0275	rRNA processing
Thein_0442	COG2001	Belongs to the MraZ family
Thein_0445	COG1086	Polysaccharide biosynthesis protein
Thein_0447	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Thein_0448	COG3980	spore coat polysaccharide biosynthesis protein
Thein_0449	COG2089	acid synthase
Thein_0451	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Thein_0455	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
Thein_0457	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Thein_0458	COG1256	bacterial-type flagellum assembly
Thein_0458	COG1256	bacterial-type flagellum assembly
Thein_0458	COG4786	Flagellar basal body rod
Thein_0458	COG4786	Flagellar basal body rod
Thein_0462	COG1706	bacterial-type flagellum-dependent cell motility
Thein_0463	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
Thein_0465	COG4786	Flagellar basal body rod
Thein_0466	COG4786	Flagellar basal body rod
Thein_0468	COG0489	protein tyrosine kinase activity
Thein_0468	COG0489	protein tyrosine kinase activity
Thein_0469	COG2894	cell division
Thein_0471	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Thein_0472	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Thein_0473	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Thein_0474	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Thein_0477	COG0390	transport system, permease component
Thein_0479	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Thein_0481	COG0805	protein transport
Thein_0482	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Thein_0483	COG4191	Histidine kinase
Thein_0489	COG0725	ABC transporter, periplasmic molybdate-binding protein
Thein_0491	COG1027	Aspartate ammonia-lyase
Thein_0498	COG4624	Iron only hydrogenase large subunit, C-terminal domain
Thein_0498	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Thein_0499	COG1160	GTP binding
Thein_0500	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Thein_0502	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
Thein_0503	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Thein_0504	COG1120	ATPase activity
Thein_0509	COG0037	tRNA processing
Thein_0510	COG1295	ribonuclease BN
Thein_0516	COG0481	GTPase activity
Thein_0517	COG0681	Belongs to the peptidase S26 family
Thein_0519	COG2199	diguanylate cyclase activity
Thein_0519	COG2203	Gaf domain
Thein_0523	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Thein_0524	COG0351	phosphomethylpyrimidine kinase
Thein_0533	COG0247	lactate metabolic process
Thein_0534	COG0482	sulfurtransferase activity
Thein_0536	COG0688	phosphatidylethanolamine metabolic process
Thein_0537	COG1183	phosphatidylcholine synthase activity
Thein_0538	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Thein_0539	COG4191	Histidine kinase
Thein_0539	COG0784	Response regulator, receiver
Thein_0540	COG0443	Heat shock 70 kDa protein
Thein_0541	COG0776	regulation of translation
Thein_0543	COG0765	amino acid transport
Thein_0544	COG0765	amino acid transport
Thein_0545	COG1126	abc transporter atp-binding protein
Thein_0548	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Thein_0552	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Thein_0553	COG0254	rRNA binding
Thein_0555	COG0167	dihydroorotate dehydrogenase activity
Thein_0556	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Thein_0557	COG0137	argininosuccinate synthase activity
Thein_0558	COG0142	geranyltranstransferase activity
Thein_0562	COG4191	Histidine kinase
Thein_0563	COG2195	Cleaves the N-terminal amino acid of tripeptides
Thein_0564	COG1254	Belongs to the acylphosphatase family
Thein_0566	COG1993	acr, cog1993
Thein_0567	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Thein_0568	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Thein_0571	COG1619	proteins homologs of microcin C7 resistance protein MccF
Thein_0575	COG4206	TonB-dependent receptor
Thein_0577	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Thein_0577	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Thein_0580	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Thein_0581	COG0305	Participates in initiation and elongation during chromosome replication
Thein_0583	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Thein_0584	COG0322	excinuclease ABC activity
Thein_0587	COG0470	DNA polymerase III
Thein_0588	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Thein_0589	COG2890	protein-(glutamine-N5) methyltransferase activity
Thein_0591	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Thein_0594	COG0438	transferase activity, transferring glycosyl groups
Thein_0596	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Thein_0597	COG0731	radical SAM domain protein
Thein_0597	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Thein_0598	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Thein_0599	COG0668	transmembrane transport
Thein_0600	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Thein_0601	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Thein_0601	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Thein_0603	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Thein_0604	COG1136	(ABC) transporter
Thein_0606	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Thein_0607	COG0210	DNA helicase
Thein_0611	COG0586	Pfam SNARE associated Golgi protein
Thein_0613	COG1074	ATP-dependent DNA helicase activity
Thein_0616	COG1030	water channel activity
Thein_0617	COG0583	DNA-binding transcription factor activity
Thein_0618	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Thein_0619	COG0460	homoserine dehydrogenase
Thein_0620	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
Thein_0624	COG0425	Belongs to the sulfur carrier protein TusA family
Thein_0625	COG2391	methyltransferase activity
Thein_0626	COG0612	Peptidase, M16
Thein_0629	COG0489	protein tyrosine kinase activity
Thein_0630	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Thein_0632	COG0706	membrane insertase activity
Thein_0633	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Thein_0634	COG0594	ribonuclease P activity
Thein_0635	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Thein_0637	COG0303	'Molybdopterin
Thein_0645	COG0335	large ribosomal subunit rRNA binding
Thein_0646	COG4752	Belongs to the RNA methyltransferase TrmD family
Thein_0647	COG0336	Belongs to the RNA methyltransferase TrmD family
Thein_0649	COG1968	undecaprenyl-diphosphatase activity
Thein_0650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Thein_0651	COG2264	protein methyltransferase activity
Thein_0658	COG0138	bifunctional purine biosynthesis protein purh
Thein_0659	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Thein_0660	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Thein_0663	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Thein_0669	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Thein_0670	COG0215	cysteine-tRNA ligase activity
Thein_0671	COG2204	response regulator
Thein_0672	COG4191	Histidine kinase
Thein_0675	COG1653	transport
Thein_0676	COG1175	transmembrane transport
Thein_0678	COG0584	glycerophosphoryl diester phosphodiesterase
Thein_0681	COG4974	Belongs to the 'phage' integrase family
Thein_0682	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Thein_0683	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Thein_0684	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Thein_0685	COG1388	LysM domain
Thein_0685	COG1376	ErfK ybiS ycfS ynhG family protein
Thein_0693	COG1132	(ABC) transporter
Thein_0695	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Thein_0700	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
Thein_0702	COG1598	PFAM Uncharacterised protein family UPF0150
Thein_0708	COG0297	glycogen (starch) synthase activity
Thein_0709	COG0367	asparagine synthase
Thein_0710	COG0438	transferase activity, transferring glycosyl groups
Thein_0713	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Thein_0715	COG1555	photosystem II stabilization
Thein_0735	COG2089	acid synthase
Thein_0736	COG1083	cytidylyl-transferase
Thein_0743	COG0217	transcriptional regulatory protein
Thein_0744	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Thein_0745	COG0632	four-way junction helicase activity
Thein_0746	COG2255	four-way junction helicase activity
Thein_0747	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Thein_0750	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Thein_0751	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Thein_0752	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Thein_0754	COG1260	myo-inositol-1-phosphate synthase
Thein_0755	COG0436	Aminotransferase
Thein_0758	COG0741	lytic transglycosylase activity
Thein_0760	COG1469	GTP cyclohydrolase I activity
Thein_0762	COG0442	prolyl-tRNA aminoacylation
Thein_0763	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Thein_0764	COG0517	IMP dehydrogenase activity
Thein_0764	COG0516	GMP reductase activity
Thein_0765	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Thein_0768	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Thein_0770	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Thein_0772	COG0535	radical SAM domain protein
Thein_0774	COG0215	cysteine-tRNA ligase activity
Thein_0776	COG3956	TIGRFAM MazG family protein
Thein_0779	COG4608	Belongs to the ABC transporter superfamily
Thein_0784	COG0444	Belongs to the ABC transporter superfamily
Thein_0787	COG0668	transmembrane transport
Thein_0788	COG1047	Peptidyl-prolyl cis-trans
Thein_0790	COG1449	Belongs to the glycosyl hydrolase 57 family
Thein_0793	COG1674	ftsk spoiiie
Thein_0798	COG0105	UTP biosynthetic process
Thein_0799	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Thein_0801	COG1332	CRISPR-associated RAMP protein, Csm5 family
Thein_0807	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Thein_0807	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Thein_0809	COG0018	arginyl-trna synthetase
Thein_0814	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Thein_0818	COG0133	tryptophan synthase activity
Thein_0819	COG0159	tryptophan synthase activity
Thein_0821	COG0343	queuine tRNA-ribosyltransferase activity
Thein_0823	COG1492	cobalamin metabolic process
Thein_0824	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Thein_0829	COG1294	oxidase, subunit
Thein_0830	COG1271	oxidase subunit
Thein_0831	COG1959	2 iron, 2 sulfur cluster binding
Thein_0832	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Thein_0833	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Thein_0834	COG2045	Belongs to the ComB family
Thein_0835	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Thein_0835	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Thein_0839	COG0504	CTP synthase activity
Thein_0840	COG0357	Ribosomal RNA small subunit methyltransferase G
Thein_0841	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Thein_0842	COG1937	Protein conserved in bacteria
Thein_0844	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Thein_0844	COG0512	Glutamine amidotransferase of anthranilate synthase
Thein_0846	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Thein_0849	COG1566	PFAM secretion protein HlyD family protein
Thein_0850	COG0477	Major facilitator Superfamily
Thein_0852	COG2078	PFAM AMMECR1 domain protein
Thein_0854	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Thein_0855	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Thein_0859	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Thein_0860	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
Thein_0863	COG0740	serine-type endopeptidase activity
Thein_0865	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Thein_0867	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Thein_0872	COG0181	hydroxymethylbilane synthase activity
Thein_0876	COG1104	cysteine desulfurase activity
Thein_0878	COG1611	Belongs to the LOG family
Thein_0879	COG1381	Involved in DNA repair and RecF pathway recombination
Thein_0881	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Thein_0883	COG2199	diguanylate cyclase activity
Thein_0884	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Thein_0885	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Thein_0889	COG1090	epimerase
Thein_0890	COG4191	Histidine kinase
Thein_0893	COG2920	part of a sulfur-relay system
Thein_0895	COG0602	queuosine metabolic process
Thein_0896	COG0720	synthase
Thein_0897	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Thein_0901	COG0445	tRNA wobble uridine modification
Thein_0903	COG1253	flavin adenine dinucleotide binding
Thein_0904	COG1253	flavin adenine dinucleotide binding
Thein_0905	COG0628	permease
Thein_0906	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Thein_0907	COG0525	valine-tRNA ligase activity
Thein_0909	COG1047	Peptidyl-prolyl cis-trans
Thein_0910	COG3852	Histidine kinase
Thein_0915	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Thein_0919	COG0067	glutamate synthase
Thein_0920	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Thein_0920	COG0069	glutamate synthase activity
Thein_0921	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Thein_0922	COG4980	gas vesicle protein
Thein_0926	COG2703	oxygen carrier activity
Thein_0927	COG0741	lytic transglycosylase activity
Thein_0927	COG1388	LysM domain
Thein_0928	COG1525	nuclease
Thein_0929	COG1605	Chorismate mutase
Thein_0929	COG0077	Prephenate dehydratase
Thein_0932	COG0569	domain protein
Thein_0933	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Thein_0934	COG0531	amino acid
Thein_0935	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Thein_0938	COG0210	DNA helicase
Thein_0943	COG0617	tRNA 3'-terminal CCA addition
Thein_0947	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Thein_0948	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Thein_0948	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Thein_0949	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Thein_0950	COG0012	GTP binding
Thein_0951	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Thein_0953	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Thein_0954	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Thein_0955	COG0454	-acetyltransferase
Thein_0955	COG0456	acetyltransferase
Thein_0957	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Thein_0958	COG1280	lysine exporter protein (LysE YggA)
Thein_0960	COG2217	Heavy metal translocating P-type atpase
Thein_0969	COG0543	2 iron, 2 sulfur cluster binding
Thein_0970	COG0107	imidazoleglycerol-phosphate synthase activity
Thein_0972	COG0511	ligase activity, forming carbon-carbon bonds
Thein_0973	COG0439	Biotin carboxylase
Thein_0974	COG5001	Diguanylate cyclase
Thein_0977	COG1475	DNA binding
Thein_0978	COG1192	Involved in chromosome partitioning
Thein_0980	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Thein_0981	COG4608	Belongs to the ABC transporter superfamily
Thein_0982	COG0444	Belongs to the ABC transporter superfamily
Thein_0984	COG0601	transmembrane transport
Thein_0985	COG0747	negative chemotaxis
Thein_0986	COG0571	ribonuclease III activity
Thein_0987	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Thein_0988	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Thein_0989	COG1058	Belongs to the CinA family
Thein_0989	COG1546	Belongs to the CinA family
Thein_0991	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Thein_0992	COG0540	Belongs to the ATCase OTCase family
Thein_0993	COG1528	Iron-storage protein
Thein_0994	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Thein_0995	COG1278	Cold shock
Thein_0996	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Thein_1002	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Thein_1003	COG0592	DNA-directed DNA polymerase activity
Thein_1004	COG0187	DNA topoisomerase II activity
Thein_1008	COG0310	cobalt ion transport
Thein_1011	COG1122	ATPase activity
Thein_1013	COG0799	negative regulation of ribosome biogenesis
Thein_1014	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Thein_1016	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Thein_1020	COG1151	hydroxylamine reductase activity
Thein_1024	COG1040	competence protein
Thein_1029	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Thein_1030	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
Thein_1031	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Thein_1032	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Thein_1033	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Thein_1034	COG0402	S-adenosylhomocysteine deaminase activity
Thein_1036	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Thein_1037	COG0312	modulator of DNA gyrase
Thein_1038	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Thein_1039	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Thein_1040	COG0840	transmembrane signaling receptor activity
Thein_1041	COG0285	dihydrofolate synthase activity
Thein_1042	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Thein_1044	COG0860	N-Acetylmuramoyl-L-alanine amidase
Thein_1045	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Thein_1046	COG1573	uracil-dna glycosylase
Thein_1049	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Thein_1050	COG0347	Belongs to the P(II) protein family
Thein_1051	COG0347	Belongs to the P(II) protein family
Thein_1052	COG0535	radical SAM domain protein
Thein_1052	COG1433	Dinitrogenase iron-molybdenum cofactor
Thein_1055	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
Thein_1058	COG0708	Exodeoxyribonuclease III
Thein_1061	COG4191	Histidine kinase
Thein_1062	COG0492	ferredoxin-NADP+ reductase activity
Thein_1064	COG0613	PHP domain protein
Thein_1065	COG1187	pseudouridine synthase activity
Thein_1066	COG0196	riboflavin kinase activity
Thein_1068	COG0505	Belongs to the CarA family
Thein_1070	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Thein_1071	COG1193	negative regulation of DNA recombination
Thein_1073	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Thein_1074	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Thein_1075	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Thein_1076	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Thein_1079	COG0559	Belongs to the binding-protein-dependent transport system permease family
Thein_1081	COG0438	transferase activity, transferring glycosyl groups
Thein_1082	COG0726	polysaccharide deacetylase
Thein_1088	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Thein_1090	COG0243	molybdopterin cofactor binding
Thein_1093	COG0037	tRNA processing
Thein_1096	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Thein_1098	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Thein_1104	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Thein_1105	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Thein_1110	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Thein_1111	COG1796	DNA polymerase
Thein_1111	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Thein_1116	COG1335	isochorismatase
Thein_1121	COG0134	indole-3-glycerol-phosphate synthase activity
Thein_1123	COG0019	diaminopimelate decarboxylase activity
Thein_1124	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Thein_1125	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Thein_1126	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Thein_1132	COG0668	transmembrane transport
Thein_1133	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Thein_1136	COG0402	S-adenosylhomocysteine deaminase activity
Thein_1137	COG0804	urea catabolic process
Thein_1139	COG0831	urea catabolic process
Thein_1142	COG0559	Belongs to the binding-protein-dependent transport system permease family
Thein_1148	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Thein_1153	COG3118	belongs to the thioredoxin family
Thein_1156	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Thein_1159	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Thein_1160	COG0411	ABC transporter
Thein_1162	COG2204	response regulator
Thein_1163	COG5000	phosphorelay sensor kinase activity
Thein_1165	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
Thein_1165	COG0778	Nitroreductase
Thein_1167	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Thein_1170	COG3876	Protein conserved in bacteria
Thein_1173	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Thein_1174	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thein_1179	COG1127	ABC transporter
Thein_1180	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Thein_1181	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Thein_1184	COG0671	phosphoesterase, PA-phosphatase related
Thein_1188	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Thein_1193	COG1379	DNA repair
Thein_1194	COG3852	Histidine kinase
Thein_1195	COG0357	Ribosomal RNA small subunit methyltransferase G
Thein_1197	COG0556	nucleotide-excision repair
Thein_1198	COG0564	pseudouridine synthase activity
Thein_1203	COG1420	regulation of RNA biosynthetic process
Thein_1204	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Thein_1205	COG0443	Heat shock 70 kDa protein
Thein_1206	COG0742	ribosomal rna small subunit methyltransferase
Thein_1207	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Thein_1209	COG0235	Class ii aldolase
Thein_1210	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Thein_1214	COG0151	Belongs to the GarS family
Thein_1218	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Thein_1219	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Thein_1221	COG3267	Type II secretory pathway component ExeA
Thein_1221	COG3409	Peptidoglycan-binding domain 1 protein
Thein_1226	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Thein_1228	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Thein_1229	COG0492	ferredoxin-NADP+ reductase activity
Thein_1229	COG3118	belongs to the thioredoxin family
Thein_1230	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
Thein_1232	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Thein_1233	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Thein_1234	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Thein_1237	COG1476	TRANSCRIPTIONal
Thein_1240	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Thein_1241	COG0228	four-way junction DNA binding
Thein_1242	COG1837	Belongs to the UPF0109 family
Thein_1243	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Thein_1244	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Thein_1245	COG0719	Fe-S assembly protein
Thein_1247	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Thein_1248	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Thein_1253	COG3290	protein histidine kinase activity
Thein_1253	COG3829	transcription factor binding
Thein_1258	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Thein_1262	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Thein_1267	COG1418	mRNA catabolic process
Thein_1268	COG1692	metallophosphoesterase
Thein_1269	COG0735	belongs to the Fur family
Thein_1280	COG0297	glycogen (starch) synthase activity
Thein_1281	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
Thein_1282	COG0606	chelatase, subunit chli
Thein_1283	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Thein_1285	COG0585	pseudouridine synthase activity
Thein_1286	COG0653	protein targeting
Thein_1288	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
Thein_1290	COG0704	Plays a role in the regulation of phosphate uptake
Thein_1291	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Thein_1292	COG0581	inorganic phosphate transmembrane transporter activity
Thein_1293	COG0573	inorganic phosphate transmembrane transporter activity
Thein_1297	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Thein_1298	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Thein_1299	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Thein_1300	COG0165	Argininosuccinate lyase
Thein_1301	COG0124	histidyl-tRNA synthetase
Thein_1306	COG0356	it plays a direct role in the translocation of protons across the membrane
Thein_1307	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Thein_1311	COG0859	PFAM glycosyl transferase family 9
Thein_1312	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Thein_1313	COG0859	PFAM glycosyl transferase family 9
Thein_1314	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Thein_1315	COG0557	exoribonuclease II activity
Thein_1316	COG3706	GGDEF domain
Thein_1318	COG0483	inositol monophosphate 1-phosphatase activity
Thein_1319	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Thein_1320	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Thein_1321	COG2703	oxygen carrier activity
Thein_1322	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Thein_1323	COG1355	regulation of microtubule-based process
Thein_1324	COG1077	Cell shape determining protein MreB Mrl
Thein_1325	COG1792	Involved in formation and maintenance of cell shape
Thein_1327	COG0768	penicillin binding
Thein_1328	COG0772	Belongs to the SEDS family
Thein_1331	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Thein_1332	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Thein_1333	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Thein_1334	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Thein_1335	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Thein_1337	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Thein_1352	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Thein_1354	COG1606	tRNA processing
Thein_1356	COG0516	GMP reductase activity
Thein_1356	COG0517	IMP dehydrogenase activity
Thein_1362	COG2226	methyltransferase
Thein_1367	COG0563	adenylate kinase activity
Thein_1368	COG0552	protein localization to endoplasmic reticulum
Thein_1369	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Thein_1371	COG1131	(ABC) transporter
Thein_1373	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Thein_1374	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Thein_1378	COG4771	TonB-dependent receptor
Thein_1380	COG5002	protein histidine kinase activity
Thein_1380	COG0784	Response regulator, receiver
Thein_1380	COG2198	Histidine kinase
Thein_1381	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Thein_1382	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Thein_1384	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Thein_1385	COG0459	protein refolding
Thein_1387	COG4783	chaperone-mediated protein folding
Thein_1388	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Thein_1389	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Thein_1392	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Thein_1395	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Thein_1397	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Thein_1400	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Thein_1402	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Thein_1404	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thein_1407	COG0456	acetyltransferase
Thein_1409	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Thein_1409	COG0574	Belongs to the PEP-utilizing enzyme family
Thein_1410	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Thein_1411	COG0126	phosphoglycerate kinase activity
Thein_1412	COG0149	triose-phosphate isomerase activity
Thein_1415	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Thein_1417	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Thein_1420	COG0674	pyruvate-flavodoxin oxidoreductase activity
Thein_1421	COG1013	pyruvate-flavodoxin oxidoreductase activity
Thein_1422	COG1151	hydroxylamine reductase activity
Thein_1424	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Thein_1426	COG1793	dna ligase
Thein_1427	COG0039	L-malate dehydrogenase activity
Thein_1431	COG0640	Transcriptional regulator
Thein_1434	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Thein_1451	COG1110	DNA topoisomerase II activity
Thein_1454	COG0752	glycyl-tRNA synthetase alpha subunit
Thein_1455	COG0751	glycine-tRNA ligase activity
Thein_1458	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Thein_1459	COG0049	tRNA binding
Thein_1460	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Thein_1461	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Thein_1462	COG0051	transcription antitermination factor activity, RNA binding
Thein_1463	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Thein_1464	COG0088	Forms part of the polypeptide exit tunnel
Thein_1465	COG0089	rRNA binding
Thein_1466	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Thein_1467	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Thein_1468	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Thein_1469	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Thein_1470	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Thein_1471	COG0255	Belongs to the universal ribosomal protein uL29 family
Thein_1472	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Thein_1473	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Thein_1474	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Thein_1475	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Thein_1476	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Thein_1477	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Thein_1479	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Thein_1480	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Thein_1481	COG1841	ribosomal large subunit assembly
Thein_1482	COG0200	Binds to the 23S rRNA
Thein_1483	COG0201	protein transport
Thein_1484	COG0563	adenylate kinase activity
Thein_1486	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Thein_1487	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Thein_1488	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Thein_1489	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Thein_1490	COG0202	RNA polymerase activity
Thein_1491	COG0203	ribosomal protein L17
Thein_1492	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
Thein_1493	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Thein_1494	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Thein_1496	COG0004	ammonium transporteR
Thein_1505	COG1061	Type III restriction enzyme res subunit
Thein_1514	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Thein_1515	COG0497	DNA recombination
Thein_1517	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Thein_1518	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Thein_1519	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Thein_1521	COG0673	inositol 2-dehydrogenase activity
Thein_1522	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Thein_1524	COG0438	transferase activity, transferring glycosyl groups
Thein_1525	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Thein_1526	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Thein_1527	COG0521	Mo-molybdopterin cofactor biosynthetic process
Thein_1528	COG0589	response to stress
Thein_1530	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Thein_1531	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Thein_1532	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Thein_1533	COG0193	aminoacyl-tRNA hydrolase activity
Thein_1534	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Thein_1535	COG0484	heat shock protein binding
Thein_1536	COG1570	exodeoxyribonuclease VII activity
Thein_1537	COG0739	heme binding
Thein_1539	COG0142	geranyltranstransferase activity
Thein_1541	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Thein_1546	COG0284	orotidine-5'-phosphate decarboxylase activity
Thein_1554	COG1797	cobyrinic acid a,c-diamide synthase activity
Thein_1558	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Thein_1561	COG1362	aminopeptidase activity
Thein_1566	COG0519	Catalyzes the synthesis of GMP from XMP
Thein_1567	COG1592	Rubrerythrin
Thein_1571	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Thein_1574	COG0732	type I restriction modification DNA specificity domain
Thein_1575	COG1404	Belongs to the peptidase S8 family
Thein_1576	COG0464	growth
Thein_1577	COG4804	nuclease activity
Thein_1578	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Thein_1583	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Thein_1583	COG2199	diguanylate cyclase activity
Thein_1585	COG0758	DNA mediated transformation
Thein_1586	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Thein_1588	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Thein_1589	COG1333	cytochrome c biogenesis protein
Thein_1590	COG1598	PFAM Uncharacterised protein family UPF0150
Thein_1592	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Thein_1593	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Thein_1595	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Thein_1597	COG0072	phenylalanine-tRNA ligase activity
Thein_1598	COG0776	regulation of translation
Thein_1601	COG0438	transferase activity, transferring glycosyl groups
Thein_1602	COG0438	transferase activity, transferring glycosyl groups
Thein_1608	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Thein_1612	COG1242	4 iron, 4 sulfur cluster binding
Thein_1615	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Thein_1616	COG1615	UPF0182 protein
Thein_1618	COG3852	Histidine kinase
Thein_1619	COG2204	response regulator
Thein_1622	COG0243	molybdopterin cofactor binding
Thein_1623	COG0437	4 iron, 4 sulfur cluster binding
Thein_1624	COG0437	4 iron, 4 sulfur cluster binding
Thein_1625	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Thein_1627	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Thein_1628	COG0649	NAD binding
Thein_1630	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Thein_1631	COG0839	Belongs to the complex I subunit 6 family
Thein_1632	COG0713	ATP synthesis coupled electron transport
Thein_1633	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Thein_1636	COG0318	PFAM AMP-dependent synthetase and ligase
Thein_1638	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Thein_1640	COG1490	D-aminoacyl-tRNA deacylase activity
Thein_1641	COG2264	protein methyltransferase activity
Thein_1643	COG1185	polyribonucleotide nucleotidyltransferase activity
Thein_1646	COG3842	ATPase activity
Thein_1647	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
Thein_1651	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Thein_1652	COG1131	(ABC) transporter
Thein_1656	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Thein_1658	COG0444	Belongs to the ABC transporter superfamily
Thein_1660	COG0601	transmembrane transport
Thein_1661	COG0747	negative chemotaxis
Thein_1667	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Thein_1670	COG0745	RESPONSE REGULATOR receiver
Thein_1671	COG0529	Catalyzes the synthesis of activated sulfate
Thein_1672	COG0438	transferase activity, transferring glycosyl groups
Thein_1674	COG0739	heme binding
Thein_1675	COG2264	protein methyltransferase activity
Thein_1676	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Thein_1677	COG0501	Belongs to the peptidase M48B family
Thein_1679	COG1663	tetraacyldisaccharide 4'-kinase activity
Thein_1680	COG1489	DNA binding
Thein_1682	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Thein_1683	COG0113	porphobilinogen synthase activity
Thein_1685	COG0432	Pfam Uncharacterised protein family UPF0047
Thein_1686	COG0629	single-stranded DNA binding
Thein_1687	COG1196	nuclear chromosome segregation
Thein_1688	COG0359	binds to the 23S rRNA
Thein_1689	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Thein_1690	COG0360	Binds together with S18 to 16S ribosomal RNA
Thein_1691	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Thein_1692	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Thein_1693	COG3901	Regulator of nitric oxide reductase transcription
Thein_1693	COG0348	domain, Protein
Thein_1696	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Thein_1699	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Thein_1700	COG1566	PFAM secretion protein HlyD family protein
Thein_1700	COG1418	mRNA catabolic process
Thein_1702	COG1530	ribonuclease E activity
Thein_1708	COG1538	Outer membrane efflux protein
Thein_1712	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Thein_1714	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Thein_1716	COG1418	mRNA catabolic process
Thein_1717	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Thein_1717	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Thein_1719	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
Thein_1720	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Thein_1721	COG0416	fatty acid biosynthetic process
Thein_1722	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Thein_1723	COG1399	metal-binding, possibly nucleic acid-binding protein
Thein_1728	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Thein_1730	COG1832	CoA-binding protein
Thein_1736	COG0367	asparagine synthase
Thein_1737	COG0109	protoheme IX farnesyltransferase activity
Thein_1750	COG0297	glycogen (starch) synthase activity
Thein_1751	COG0463	Glycosyl transferase, family 2
Thein_1753	COG0673	inositol 2-dehydrogenase activity
Thein_1762	COG1785	Belongs to the alkaline phosphatase family
Thein_1770	COG1702	phosphate starvation-inducible protein PhoH
Thein_1774	COG1872	DUF167
Thein_1775	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Thein_1776	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Thein_1776	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
Thein_1784	COG3259	Nickel-dependent hydrogenase
Thein_1785	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Thein_1804	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
Thein_1805	COG0157	Belongs to the NadC ModD family
Thein_1806	COG2204	response regulator
Thein_1808	COG2204	response regulator
Thein_1810	COG1558	bacterial-type flagellum-dependent cell motility
Thein_1811	COG1677	Flagellar hook-basal body complex protein FliE
Thein_1812	COG1766	The M ring may be actively involved in energy transduction
Thein_1813	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Thein_1815	COG1157	protein secretion by the type III secretion system
Thein_1820	COG0437	4 iron, 4 sulfur cluster binding
Thein_1827	COG0495	leucyl-tRNA aminoacylation
Thein_1828	COG0538	isocitrate dehydrogenase activity
Thein_1831	COG2204	response regulator
Thein_1836	COG0802	atpase or kinase
Thein_1837	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Thein_1837	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Thein_1838	COG0037	tRNA processing
Thein_1841	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Thein_1842	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Thein_1844	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Thein_1845	COG1773	rubredoxin
Thein_1845	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Thein_1849	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Thein_1850	COG2226	methyltransferase
Thein_1851	COG1329	Transcriptional regulator
Thein_1852	COG4956	integral membrane protein (PIN domain superfamily)
Thein_1853	COG0303	'Molybdopterin
Thein_1855	COG0066	3-isopropylmalate dehydratase activity
Thein_1858	COG3842	ATPase activity
Thein_1862	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Thein_1863	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Thein_1864	COG1121	(ABC) transporter
Thein_1866	COG0494	nUDIX hydrolase
Thein_1867	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Thein_1868	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Thein_1869	COG0564	pseudouridine synthase activity
Thein_1875	COG0010	Belongs to the arginase family
Thein_1877	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Thein_1877	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Thein_1885	COG3267	Type II secretory pathway component ExeA
Thein_1885	COG3409	Peptidoglycan-binding domain 1 protein
Thein_1887	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Thein_1891	COG2252	PERMEase
Thein_1892	COG1980	fructose-bisphosphate aldolase activity
Thein_1896	COG1797	cobyrinic acid a,c-diamide synthase activity
Thein_1898	COG2875	Belongs to the precorrin methyltransferase family
Thein_1900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Thein_1901	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Thein_1907	COG0123	including yeast histone deacetylase and acetoin utilization protein
Thein_1908	COG2095	MarC family integral membrane protein
Thein_1909	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Thein_1909	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Thein_1910	COG2003	Belongs to the UPF0758 family
Thein_1911	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Thein_1912	COG0590	tRNA wobble adenosine to inosine editing
Thein_1915	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Thein_1916	COG1322	Protein conserved in bacteria
Thein_1918	COG0028	Belongs to the TPP enzyme family
Thein_1919	COG0440	acetolactate synthase activity
Thein_1920	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Thein_1921	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Thein_1922	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Thein_1923	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Thein_1950	COG0629	single-stranded DNA binding
Thein_1980	COG4974	Belongs to the 'phage' integrase family
Thein_1981	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Thein_1982	COG0569	domain protein
Thein_1983	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Thein_1985	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
Thein_1985	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Thein_1987	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Thein_1988	COG0439	Biotin carboxylase
Thein_1989	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Thein_1995	COG0848	biopolymer transport protein
Thein_1996	COG0811	peptide transport
Thein_2002	COG1122	ATPase activity
Thein_2009	COG4206	TonB-dependent receptor
Thein_2010	COG0409	Hydrogenase expression formation protein
Thein_2013	COG0268	Binds directly to 16S ribosomal RNA
Thein_2014	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
Thein_2015	COG1056	cytidyltransferase-related domain
Thein_2015	COG1051	belongs to the nudix hydrolase family
Thein_2017	COG0352	thiamine-phosphate diphosphorylase activity
Thein_2019	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Thein_2019	COG1042	CoA-binding domain protein
Thein_2019	COG0045	succinate-CoA ligase (ADP-forming) activity
Thein_2020	COG0123	including yeast histone deacetylase and acetoin utilization protein
Thein_2024	COG0247	lactate metabolic process
Thein_2025	COG0277	FAD linked oxidase domain protein
Thein_2026	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Thein_2028	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Thein_2029	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Thein_2030	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Thein_2030	COG1773	rubredoxin
Thein_2031	COG0587	DNA-directed DNA polymerase activity
Thein_2036	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Thein_2038	COG4974	Belongs to the 'phage' integrase family
Thein_2039	COG0617	tRNA 3'-terminal CCA addition
Thein_2040	COG1994	Peptidase M50
Thein_2043	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Thein_2045	COG1543	Belongs to the glycosyl hydrolase 57 family
Thein_2048	COG0668	transmembrane transport
Thein_2050	COG0047	phosphoribosylformylglycinamidine synthase activity
Thein_2051	COG0805	protein transport
Thein_2052	COG0405	Gamma-glutamyltransferase
Thein_2053	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Thein_2054	COG1473	amidohydrolase
Thein_2055	COG2033	superoxide reductase activity
Thein_2056	COG0426	domain, Protein
Thein_2058	COG1509	lysine 2,3-aminomutase activity
Thein_2061	COG0840	transmembrane signaling receptor activity
Thein_2062	COG2204	response regulator
Thein_2063	COG4191	Histidine kinase
Thein_2064	COG2204	response regulator
Thein_2067	COG0730	response to heat
Thein_2069	COG1233	COG1233 Phytoene dehydrogenase and related
Thein_2073	COG0543	2 iron, 2 sulfur cluster binding
Thein_2079	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Thein_2081	COG0737	Belongs to the 5'-nucleotidase family
Thein_2083	COG0110	maltose O-acetyltransferase activity
Thein_2085	COG0410	ABC transporter
Thein_2086	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Thein_2088	COG0750	zinc metalloprotease
Thein_2090	COG0575	Belongs to the CDS family
Thein_2092	COG0233	cytoplasmic translational termination
Thein_2093	COG0528	UMP kinase activity
Thein_2094	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Thein_2095	COG0052	Belongs to the universal ribosomal protein uS2 family
Thein_2100	COG0542	response to heat
Thein_2105	COG0180	Tryptophanyl-tRNA synthetase
Thein_2110	COG2414	aldehyde ferredoxin oxidoreductase
Thein_2117	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Thein_2118	COG1216	Glycosyl transferase, family 2
Thein_2120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Thein_2120	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Thein_2121	COG1774	PSP1 C-terminal conserved region
Thein_2123	COG0135	phosphoribosylanthranilate isomerase activity
Thein_2124	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Thein_2125	COG2165	general secretion pathway protein
Thein_2133	COG1450	Type ii and iii secretion system protein
Thein_2136	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Thein_2138	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Thein_2140	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Thein_2144	COG2884	Cell division ATP-binding protein ftsE
Thein_2146	COG4942	peptidase
Thein_2147	COG0793	Belongs to the peptidase S41A family
Thein_2148	COG2861	carbohydrate metabolic process
Thein_2149	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Thein_2150	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Thein_2151	COG0463	Glycosyl transferase, family 2
Thein_2154	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Thein_2155	COG0446	pyridine nucleotide-disulphide oxidoreductase
Thein_2156	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Thein_2157	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Thein_2159	COG1176	ABC-type spermidine putrescine transport system, permease component I
Thein_2161	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Thein_2163	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Thein_2166	COG0840	transmembrane signaling receptor activity
Thein_2168	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Thein_2168	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Thein_2169	COG0776	regulation of translation
Thein_2170	COG0148	phosphopyruvate hydratase activity
Thein_2172	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Thein_2173	COG1773	rubredoxin
Thein_2178	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Thein_2190	COG1151	hydroxylamine reductase activity
Thein_2191	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Thein_2192	COG2759	Belongs to the formate--tetrahydrofolate ligase family
Thein_2196	COG0174	glutamine synthetase
Thein_2197	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Thein_2198	COG0347	Belongs to the P(II) protein family
Thein_2200	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Thein_2201	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Thein_2202	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Thein_2205	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Thein_2206	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Thein_2208	COG1605	Chorismate mutase
Thein_2208	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Thein_2209	COG2095	MarC family integral membrane protein
Thein_2210	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Thein_2212	COG0436	Aminotransferase
Thein_2214	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Thein_2216	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
Thein_2219	COG5002	protein histidine kinase activity
Thein_2224	COG0243	molybdopterin cofactor binding
Thein_2226	COG1918	ferrous iron import across plasma membrane
Thein_2226	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Thein_2229	COG0864	Transcriptional regulator
Thein_R0030	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene