locus-tag	class	description
HL41_00040	ENOG4107QXV	Phosphate transporter
HL41_00070	ENOG4105C0P	Mg chelatase subunit ChlI
HL41_00075	ENOG4105VH4	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HL41_00080	ENOG4107WJT	it plays a direct role in the translocation of protons across the membrane (By similarity)
HL41_00095	ENOG4105CIZ	coA-substrate-specific enzyme activase
HL41_00100	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
HL41_00120	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
HL41_00145	ENOG4107S47	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity)
HL41_00150	ENOG4105CSA	Coproporphyrinogen iii oxidase
HL41_00165	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HL41_00170	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HL41_00175	ENOG4108YZG	isomerase
HL41_00180	ENOG410829W	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
HL41_00185	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
HL41_00200	ENOG4105ES5	Histidine kinase
HL41_00220	ENOG4105M8K	biopolymer transport protein
HL41_00225	ENOG4105M15	transport protein ExbD
HL41_00240	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HL41_00245	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
HL41_00275	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
HL41_00280	ENOG4105DB7	PHP domain protein
HL41_00285	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
HL41_00300	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HL41_00310	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
HL41_00315	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
HL41_00320	ENOG4108MYP	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
HL41_00330	ENOG4105VEQ	Cold shock protein
HL41_00340	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
HL41_00345	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HL41_00355	ENOG4105EAU	Plays a role in nitrite reduction (By similarity)
HL41_00360	ENOG4107R7Y	intracellular protease Pfpi family
HL41_00370	ENOG4108JVH	Protein of unknown function DUF43
HL41_00375	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
HL41_00390	ENOG4105BZU	Histidine kinase
HL41_00395	ENOG4105W49	UPF0434 protein
HL41_00405	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HL41_00415	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
HL41_00420	ENOG4107YU2	histidine triad (hIT) protein
HL41_00425	ENOG4106063	Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit
HL41_00430	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
HL41_00435	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
HL41_00440	ENOG410836E	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
HL41_00445	ENOG4105VB6	UPF0109 protein
HL41_00450	ENOG4105K5M	30s ribosomal protein S16
HL41_00460	ENOG4105EAQ	(twin-arginine translocation) pathway signal
HL41_00465	ENOG4105DIT	ErfK YbiS YcfS YnhG family protein
HL41_00475	ENOG4105CR5	Class II aldolase adducin family protein
HL41_00480	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
HL41_00485	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
HL41_00490	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
HL41_00530	ENOG41083MZ	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
HL41_00535	ENOG4108ZC9	flagellar basal-body rod protein flgc
HL41_00540	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
HL41_00545	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
HL41_00550	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
HL41_00580	ENOG4105G5W	regulator Fur family
HL41_00590	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
HL41_00595	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
HL41_00600	ENOG4105CS1	NAD(P)H quinone oxidoreductase
HL41_00605	ENOG4105CH7	arginosuccinase
HL41_00645	ENOG4105E3H	phosphoglycerate mutase
HL41_00650	ENOG4108IYU	L-aspartate oxidase
HL41_00660	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HL41_00670	ENOG4105EGD	dinuclear metal center protein, YbgI family
HL41_00680	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
HL41_00685	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
HL41_00710	ENOG4105F4G	Membrane
HL41_00725	ENOG4107Z7S	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
HL41_00730	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HL41_00735	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
HL41_00740	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
HL41_00750	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HL41_00765	ENOG41084CW	50S ribosomal protein L32
HL41_00775	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HL41_00825	ENOG4105DFM	M18 family aminopeptidase
HL41_00835	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
HL41_00855	ENOG4105EM7	Selenocysteine-specific translation elongation factor
HL41_00860	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
HL41_00865	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
HL41_00870	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
HL41_00895	ENOG41071I4	Phosphatidylserine decarboxylase proenzyme
HL41_00905	ENOG4105KC4	UPF0296 protein
HL41_00910	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
HL41_00915	ENOG4105C2N	RNA methyltransferase TrmH family group 3
HL41_00935	ENOG4105CRK	lysyL-tRNA synthetase
HL41_00940	ENOG4105D60	lipoprotein releasing system transmembrane protein
HL41_00945	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HL41_00950	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HL41_00960	ENOG4108JQA	flagellar
HL41_00965	ENOG4105CGA	flagellar basal-body rod protein FlgG
HL41_00980	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
HL41_00995	ENOG4105E1Q	flagellar hook-associated protein
HL41_01005	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
HL41_01010	ENOG4107SDT	Homocitrate synthase
HL41_01015	ENOG4105CHM	Aminotransferase
HL41_01030	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
HL41_01045	ENOG4105D98	threonine synthase
HL41_01050	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
HL41_01065	ENOG4105CNI	cell division protein FtsW
HL41_01080	ENOG4105E3N	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HL41_01085	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
HL41_01090	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
HL41_01095	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
HL41_01100	ENOG41082MC	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HL41_01105	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
HL41_01110	ENOG4105DFA	alanine racemase domain protein
HL41_01125	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
HL41_01135	ENOG4107RD7	Flagellar Motor Protein, MotA
HL41_01145	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
HL41_01150	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
HL41_01155	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HL41_01160	ENOG4105CFG	Acts as a chaperone (By similarity)
HL41_01165	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
HL41_01185	ENOG4105C75	arginyL-tRNA synthetase
HL41_01195	ENOG4108Z1Z	gCN5-related N-acetyltransferase
HL41_01200	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
HL41_01210	ENOG4105C1G	acyl-Coa dehydrogenase
HL41_01215	ENOG4105BZJ	Electron transfer flavoprotein
HL41_01220	ENOG4105C10	Electron transfer flavoprotein
HL41_01230	ENOG4105C9M	aspartyl-trna synthetase
HL41_01235	ENOG4105F8V	Hydrolase, tatD family
HL41_01240	ENOG4105CC5	ABC transporter
HL41_01245	ENOG4105FDK	ABC transporter
HL41_01250	ENOG4105DXN	mazG family
HL41_01255	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HL41_01260	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HL41_01265	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HL41_01285	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HL41_01290	ENOG4105VB9	50S ribosomal protein l28
HL41_01295	ENOG4107QNG	Phosphoribosylglycinamide synthetase
HL41_01300	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
HL41_01305	ENOG4106855	Competence protein
HL41_01315	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HL41_01320	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
HL41_01330	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
HL41_01335	ENOG4105CE9	30S ribosomal protein S2
HL41_01340	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
HL41_01345	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
HL41_01350	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
HL41_01355	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
HL41_01370	ENOG4105CPF	Cell wall formation (By similarity)
HL41_01385	ENOG4105N5T	Radical SAM Protein
HL41_01390	ENOG4105D5U	fad dependent oxidoreductase
HL41_01400	ENOG410816I	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
HL41_01405	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
HL41_01415	ENOG4105C79	DNA protecting protein DprA
HL41_01430	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
HL41_01440	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
HL41_01445	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HL41_01450	ENOG4105VFF	UPF0102 protein
HL41_01475	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
HL41_01520	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
HL41_01525	ENOG4105D48	metallophosphoesterase
HL41_01530	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HL41_01540	ENOG4107SYB	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
HL41_01550	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HL41_01565	ENOG4105C5I	Dehydrogenase
HL41_01570	ENOG4105WCJ	ec 1.1.1.193
HL41_01580	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
HL41_01585	ENOG4105K46	50S ribosomal protein l27
HL41_01590	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
HL41_01605	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
HL41_01640	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
HL41_01650	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
HL41_01660	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
HL41_01670	ENOG4105W3S	hemerythrin-like, metal-binding protein
HL41_01710	ENOG4105E4G	Type IV pilus
HL41_01715	ENOG4108FW6	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity)
HL41_01725	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
HL41_01730	ENOG4105CHM	Aminotransferase
HL41_01760	ENOG4107Z3H	Transcriptional regulator, TetR family
HL41_01775	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
HL41_01790	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
HL41_01815	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HL41_01820	ENOG4105IQJ	Involved in biosynthesis of the thiamine precursor thiazole (By similarity)
HL41_01830	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HL41_01845	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
HL41_01850	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
HL41_01855	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
HL41_01870	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HL41_01880	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
HL41_01895	ENOG4105CZX	twitching motility protein
HL41_01900	ENOG4105CZX	twitching motility protein
HL41_01915	ENOG4105C25	Primosomal protein n'
HL41_01935	ENOG4105EZY	Pyrroloquinoline quinone biosynthesis protein E
HL41_01940	ENOG4105DC1	bifunctional purine biosynthesis protein purh
HL41_01950	ENOG4105E2X	shikimate dehydrogenase
HL41_01955	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
HL41_01960	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
HL41_01965	ENOG4105C5X	domain protein
HL41_01970	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
HL41_01980	ENOG4105DCG	PHP domain protein
HL41_01985	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
HL41_02000	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
HL41_02005	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HL41_02010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
HL41_02015	ENOG4105C3M	thioredoxin reductase
HL41_02020	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
HL41_02025	ENOG4108194	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
HL41_02030	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
HL41_02035	ENOG4105D0M	Protease HtpX homolog
HL41_02040	ENOG4105CQC	Prephenate dehydratase
HL41_02050	ENOG4105CHV	Transcription elongation factor NusA
HL41_02055	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
HL41_02105	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HL41_02115	ENOG4105EYU	Glutamine amido-transferase
HL41_02120	ENOG4105CBC	glutamate synthase
HL41_02130	ENOG4105C5F	glutamine synthetase
HL41_02135	ENOG4108JUA	Transcriptional regulator
HL41_02145	ENOG4108YZA	Nitrogen regulatory protein pii
HL41_02150	ENOG4105BZU	Histidine kinase
HL41_02165	ENOG4105CAH	Chromate
HL41_02180	ENOG4107R7I	amino acid
HL41_02205	ENOG4105FNP	Molybdopterin-guanine dinucleotide biosynthesis protein b
HL41_02210	ENOG4105E8R	UPF0173 metal-dependent hydrolase
HL41_02220	ENOG4105DDK	oxidoreductase, beta subunit
HL41_02225	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
HL41_02245	ENOG4105DBV	ornithine carbamoyltransferase
HL41_02255	ENOG4105C3U	ABC transporter
HL41_02270	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
HL41_02275	ENOG4105CQB	FAD linked oxidase domain protein
HL41_02285	ENOG4105DUN	Mediates zinc uptake. May also transport other divalent cations (By similarity)
HL41_02290	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HL41_02295	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HL41_02300	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
HL41_02335	ENOG4105C89	phosphohexose isomerase
HL41_02340	ENOG4105D52	delta-aminolevulinic acid dehydratase
HL41_02345	ENOG4105K6T	rare lipoprotein A
HL41_02360	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
HL41_02365	ENOG4107SDU	Methyl-accepting chemotaxis
HL41_02370	ENOG4105I3K	Ferric uptake regulator, Fur family
HL41_02375	ENOG4105D06	uba thif-type nad fad binding protein
HL41_02385	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HL41_02390	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
HL41_02395	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
HL41_02400	ENOG4105C4M	(Ubiquinol oxidase) subunit I
HL41_02415	ENOG4105BZU	Histidine kinase
HL41_02435	ENOG4105C8V	SAICAR synthetase
HL41_02475	ENOG4105E3H	phosphoglycerate mutase
HL41_02485	ENOG4107XQ1	cobalamin (vitamin B12) biosynthesis CbiM protein
HL41_02490	ENOG4108A51	
HL41_02495	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
HL41_02510	ENOG4107S21	permease
HL41_02520	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
HL41_02530	ENOG4108J5G	6-phosphogluconate dehydrogenase
HL41_02550	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HL41_02555	ENOG4105BZU	Histidine kinase
HL41_02560	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HL41_02585	ENOG4108VYJ	response regulator receiver protein
HL41_02590	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HL41_02595	ENOG4107R21	site-determining protein
HL41_02600	ENOG4105FZW	flagellar biosynthesis regulator FlhF
HL41_02605	ENOG4105D7B	Flagellar biosynthesis protein flha
HL41_02610	ENOG4105D00	flagellar biosynthetic protein flhB
HL41_02615	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
HL41_02620	ENOG4105VS8	Flagellar biosynthetic protein fliq
HL41_02625	ENOG4105CN7	Flagellar biosynthetic protein FliP
HL41_02635	ENOG4105DD5	Flagellar motor switch protein
HL41_02640	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
HL41_02660	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
HL41_02670	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
HL41_02675	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
HL41_02690	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
HL41_02700	ENOG4107ZMQ	sugar fermentation stimulation protein
HL41_02720	ENOG4105DR4	Methyltransferase
HL41_02735	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
HL41_02745	ENOG4105C8B	TIGR00159 family
HL41_02765	ENOG4108IUZ	ABC transporter
HL41_02790	ENOG4108UVJ	appr-1-p processing domain protein
HL41_02800	ENOG4105C8Q	Methyl-accepting chemotaxis
HL41_02815	ENOG4105C8Q	Methyl-accepting chemotaxis
HL41_02825	ENOG4105EC8	Methyl-accepting chemotaxis
HL41_02830	ENOG4105ECP	epimerase
HL41_02840	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
HL41_02845	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HL41_02850	ENOG4105DSE	periplasmic solute binding protein
HL41_02875	ENOG4105DIW	FeS assembly protein SUFB
HL41_02880	ENOG4105CIH	Imidazole acetol-phosphate transaminase
HL41_02885	ENOG4105BZU	Histidine kinase
HL41_02925	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
HL41_02930	ENOG4105EE5	Membrane protein terC
HL41_02935	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
HL41_02940	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
HL41_02945	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HL41_02950	ENOG4105C8Q	Methyl-accepting chemotaxis
HL41_02980	ENOG4105YVF	chew protein
HL41_02985	ENOG4105CBS	Chea signal transduction histidine kinase
HL41_02990	ENOG4108TVT	permease
HL41_02995	ENOG4105FE9	pseudouridine synthase
HL41_03005	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
HL41_03015	ENOG4107R56	PP-loop domain protein
HL41_03030	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
HL41_03035	ENOG4105C3F	Signal peptidase i
HL41_03040	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HL41_03050	ENOG4105CJ1	ABC, transporter
HL41_03080	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
HL41_03085	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
HL41_03090	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
HL41_03105	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
HL41_03120	ENOG41082E4	Binds directly to 16S ribosomal RNA (By similarity)
HL41_03130	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
HL41_03135	ENOG41074MP	UPF0103 Mediator of ErbB2-driven cell motility-containing protein
HL41_03140	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
HL41_03145	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
HL41_03175	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
HL41_03180	ENOG4105CUB	amino acid
HL41_03190	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
HL41_03195	ENOG4108EE5	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HL41_03200	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HL41_03205	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HL41_03225	ENOG4105BZU	Histidine kinase
HL41_03230	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
HL41_03240	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
HL41_03245	ENOG4105CAS	nag kinase
HL41_03305	ENOG4107VRB	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
HL41_03330	ENOG4105C37	(CBS) domain
HL41_03335	ENOG4105C37	(CBS) domain
HL41_03370	ENOG4105MRR	Transcriptional regulator (By similarity)
HL41_03375	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HL41_03380	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
HL41_03390	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HL41_03395	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
HL41_03405	ENOG4107YUK	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
HL41_03420	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
HL41_03425	ENOG4105C22	threonyL-tRNA synthetase
HL41_03440	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HL41_03460	ENOG4108Z6B	deaminase
HL41_03470	ENOG4105W5Q	DNA repair protein (RadC
HL41_03480	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
HL41_03485	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
HL41_03490	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
HL41_03500	ENOG4105CDH	Citrulline--aspartate ligase
HL41_03505	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
HL41_03515	ENOG4107G9V	glycosyl transferase, family 39
HL41_03520	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
HL41_03530	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
HL41_03545	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
HL41_03550	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
HL41_03555	ENOG4105MYT	Heat shock protein
HL41_03560	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HL41_03570	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
HL41_03575	ENOG4105KEG	ribosomal-protein-alanine acetyltransferase
HL41_03590	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HL41_03595	ENOG4105M7K	Involved in the transcription termination process (By similarity)
HL41_03600	ENOG4105CAT	Cytidine monophosphate kinase
HL41_03610	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
HL41_03635	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
HL41_03645	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
HL41_03655	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
HL41_03660	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
HL41_03665	ENOG4105CTQ	phosphohexokinase
HL41_03680	ENOG4107ZTM	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
HL41_03685	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HL41_03690	ENOG4105C31	Tryptophanyl-tRNA synthetase
HL41_03705	ENOG4108NWD	Cytochrome
HL41_03720	ENOG4105DZS	Phenylacetate-CoA ligase
HL41_03730	ENOG4105C1J	atp-dependent rna helicase
HL41_03735	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HL41_03740	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
HL41_03750	ENOG4105DCU	2-hydroxyglutaryl-CoA dehydratase
HL41_03755	ENOG4105CIZ	coA-substrate-specific enzyme activase
HL41_03770	ENOG4105VFE	sira family
HL41_03790	ENOG4105CTX	dehydratase
HL41_03795	ENOG4105CTX	dehydratase
HL41_03800	ENOG41061AI	Protein of unknown function (DUF2905)
HL41_03805	ENOG4105DVY	radical SAM domain protein
HL41_03820	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HL41_03840	ENOG4105C0D	helicase
HL41_03845	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
HL41_03850	ENOG4105CEY	Amp-dependent synthetase and ligase
HL41_03860	ENOG4108N5B	2-phosphosulfolactate phosphatase
HL41_03915	ENOG4105C0D	helicase
HL41_03930	ENOG4108XDW	curli assembly protein CsgE
HL41_03970	ENOG4105C4K	Nad synthetase
HL41_03975	ENOG4105C5F	glutamine synthetase
HL41_03985	ENOG4108JUA	Transcriptional regulator
HL41_03995	ENOG4105D1F	ATP-binding protein
HL41_04010	ENOG410801E	Flagellar hook-associated 2 domain-containing protein
HL41_04015	ENOG4105MQ3	flagellar protein FliS
HL41_04045	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
HL41_04050	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
HL41_04055	ENOG4105DK0	Indole-3-glycerol phosphate synthase
HL41_04060	ENOG41085QA	50S ribosomal protein l34
HL41_04070	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
HL41_04075	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HL41_04085	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
HL41_04090	ENOG4105DWF	phosphomethylpyrimidine kinase
HL41_04095	ENOG4105VB5	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HL41_04100	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HL41_04105	ENOG410636K	Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity)
HL41_04115	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
HL41_04135	ENOG4105CEV	competence damage-inducible protein
HL41_04140	ENOG4108ZAI	phosphatidylglycerophosphatase a
HL41_04150	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
HL41_04155	ENOG4105BZU	Histidine kinase
HL41_04165	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HL41_04175	ENOG4107S1Q	Phosphatase
HL41_04220	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HL41_04220	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HL41_04235	ENOG41084JP	30S ribosomal protein S21
HL41_04240	ENOG4107QHF	type ii secretion system protein e
HL41_04250	ENOG4105CY0	Metallo-Beta-Lactamase
HL41_04255	ENOG4108T9Q	UPF0278 protein
HL41_04265	ENOG4105C8T	Leucyl-tRNA synthetase
HL41_04270	ENOG410688J	Ferredoxin
HL41_04275	ENOG4108HMX	isocitrate dehydrogenase (NADP)
HL41_04290	ENOG4105CHM	Aminotransferase
HL41_04300	ENOG4105SG9	biopolymer transport protein, ExbD
HL41_04310	ENOG4107NFR	Fructose-1,6-bisphosphatase
HL41_04315	ENOG4105VM1	flagellar
HL41_04320	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
HL41_04350	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
HL41_04360	ENOG4107UU3	sucrose-phosphate synthase (EC 2.4.1.14)
HL41_04365	ENOG41088YS	Glycosyl transferase (Group 1
HL41_04415	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
HL41_04425	ENOG4105D0M	Protease HtpX homolog
HL41_04430	ENOG4105BZ1	(ABC) transporter
HL41_04440	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
HL41_04445	ENOG4105C03	ribonuclease
HL41_04460	ENOG4105DVI	reductase, NrfD
HL41_04465	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
HL41_04470	ENOG4108J2R	molybdopterin oxidoreductase
HL41_04475	ENOG4105EBH	Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity)
HL41_04480	ENOG4105CN1	protease
HL41_04485	ENOG4108Z4T	Peptidase M50
HL41_04515	ENOG4105BZU	Histidine kinase
HL41_04520	ENOG4108TVJ	Nitroreductase
HL41_04545	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
HL41_04560	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
HL41_04570	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
HL41_04575	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
HL41_04580	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HL41_04585	ENOG4107VXZ	Hydrolase
HL41_04610	ENOG4105C8Q	Methyl-accepting chemotaxis
HL41_04615	ENOG4105BZU	Histidine kinase
HL41_04625	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HL41_04630	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
HL41_04640	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HL41_04660	ENOG4105CKX	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP
HL41_04670	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HL41_04680	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HL41_04685	ENOG4105BZU	Histidine kinase
HL41_04690	ENOG4105K64	Glycosyl transferase, family 2
HL41_04695	ENOG4105CB5	ATP-dependent DNA helicase recG
HL41_04710	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
HL41_04725	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HL41_04735	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
HL41_04740	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
HL41_04745	ENOG4108R6K	riboflavin synthase, subunit alpha
HL41_04755	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
HL41_04775	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
HL41_04780	ENOG410812A	polypeptide-transport-associated domain protein, FtsQ-type
HL41_04790	ENOG4105DFU	Cell wall formation (By similarity)
HL41_04805	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
HL41_04810	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
HL41_04815	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
HL41_04830	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
HL41_04835	ENOG4108V6E	Cell division protein mraZ
HL41_04880	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HL41_04935	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
HL41_04945	ENOG4105C5R	Aminotransferase
HL41_04950	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
HL41_04955	ENOG4105DC1	bifunctional purine biosynthesis protein purh
HL41_04960	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HL41_04975	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HL41_04980	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
HL41_04995	ENOG4105DHJ	ABC, transporter
HL41_05005	ENOG4105C01	Dihydroxy-acid dehydratase
HL41_05010	ENOG41083MR	nifu domain-containing protein
HL41_05015	ENOG41084BP	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
HL41_05020	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HL41_05025	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HL41_05030	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HL41_05035	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
HL41_05040	ENOG4105N1P	Ferredoxin-type protein
HL41_05050	ENOG4105FE9	pseudouridine synthase
HL41_05060	ENOG4105W87	Cbs domain
HL41_05080	ENOG4105DZP	Membrane-associated zinc metalloprotease
HL41_05085	ENOG41072GX	Peptidase M22 Glycoprotease
HL41_05095	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HL41_05105	ENOG4107T5V	SNARE associated Golgi
HL41_05110	ENOG4107Y7W	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity)
HL41_05135	ENOG4105DPX	Hydrogenase, large subunit
HL41_05140	ENOG4105CQS	hydrogenase expression formation protein HypD
HL41_05150	ENOG4108VTU	Cdp-alcohol phosphatidyltransferase
HL41_05155	ENOG4107QJE	Chromosome Partitioning Protein
HL41_05160	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
HL41_05170	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
HL41_05175	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
HL41_05195	ENOG4105C7N	Xanthine uracil vitamin C permease
HL41_05210	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
HL41_05275	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HL41_05280	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
HL41_05285	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
HL41_05290	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
HL41_05295	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
HL41_05305	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HL41_05310	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
HL41_05315	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
HL41_05320	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HL41_05330	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
HL41_05340	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HL41_05345	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
HL41_05350	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
HL41_05355	ENOG4105VPB	50S ribosomal protein L30
HL41_05360	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
HL41_05365	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
HL41_05370	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
HL41_05375	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
HL41_05380	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
HL41_05385	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HL41_05390	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
HL41_05395	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
HL41_05400	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
HL41_05405	ENOG41082SA	50s ribosomal protein l29
HL41_05410	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
HL41_05415	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
HL41_05420	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
HL41_05425	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
HL41_05430	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HL41_05435	ENOG41080UE	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
HL41_05440	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
HL41_05445	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HL41_05450	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
HL41_05455	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HL41_05460	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HL41_05465	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
HL41_05470	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
HL41_05475	ENOG4105D1H	recombination factor protein RarA
HL41_05500	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HL41_05505	ENOG4108UK2	deaminase
HL41_05510	ENOG4105DVC	DnaJ domain protein
HL41_05525	ENOG4108TVJ	Nitroreductase
HL41_05530	ENOG4105T95	Thiol disulfide interChange protein
HL41_05535	ENOG4105NBF	ammecr1 domain protein
HL41_05550	ENOG4108TVJ	Nitroreductase
HL41_05555	ENOG4105T95	Thiol disulfide interChange protein
HL41_05560	ENOG4105NBF	ammecr1 domain protein
HL41_05580	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HL41_05585	ENOG4105CFH	Aspartokinase
HL41_05590	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
HL41_05600	ENOG4105C8N	cysteinyl-tRNA synthetase
HL41_05610	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
HL41_05615	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
HL41_05620	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
HL41_05625	ENOG4108UJD	30S ribosomal protein S9
HL41_05630	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
HL41_05655	ENOG4105C7K	acetolactate synthase
HL41_05660	ENOG4108ZP8	Acetolactate synthase small subunit
HL41_05665	ENOG4105CV1	Transketolase (EC 2.2.1.1)
HL41_05670	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
HL41_05675	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
HL41_05685	ENOG4105Z0W	Dissimilatory sulfite reductase D
HL41_05695	ENOG4105CY1	sulfite reductase, dissimilatory-type alpha subunit
HL41_05700	ENOG4105CAK	Cell division ATP-binding protein ftsE
HL41_05740	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
HL41_05755	ENOG4105CHR	reductase
HL41_05760	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
HL41_05770	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
HL41_05835	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
HL41_05840	ENOG4105CDY	transcriptional regulatory protein
HL41_05855	ENOG4105VCQ	rubredoxin
HL41_05875	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
HL41_05880	ENOG4105C34	Pseudouridine synthase
HL41_05900	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
HL41_05920	ENOG4105CNW	domain protein
HL41_05935	ENOG4105VCQ	rubredoxin
HL41_05945	ENOG4105MAX	Superoxide reductase
HL41_05960	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
HL41_05965	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
HL41_05970	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
HL41_05975	ENOG41085CK	50S ribosomal protein L35
HL41_06025	ENOG4105CE1	Ferrous iron transport protein b
HL41_06030	ENOG4105XFK	Ferrous iron transport protein A
HL41_06040	ENOG4105BZU	Histidine kinase
HL41_06050	ENOG4105D3R	alkyl hydroperoxide reductase
HL41_06065	ENOG4108RAC	Rubrerythrin
HL41_06070	ENOG4105BZE	flagellar hook protein, FlgE
HL41_06075	ENOG4105BZE	flagellar hook protein, FlgE
HL41_06090	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HL41_06095	ENOG4105C8S	subunit m
HL41_06105	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HL41_06120	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
HL41_06125	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HL41_06135	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HL41_06145	ENOG4105QAX	Iron-sulfur
HL41_06155	ENOG4105K4P	CoA-binding domain protein
HL41_06160	ENOG4105BZA	Phosphoglycerate kinase
HL41_06165	ENOG4105BZA	Phosphoglycerate kinase
HL41_06185	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
HL41_06190	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
HL41_06195	ENOG4105EYH	Exonuclease
HL41_06200	ENOG41085AN	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
HL41_06220	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
HL41_06225	ENOG4105E63	Pfam:DUF178
HL41_06230	ENOG4105E02	MotA TolQ exbB proton channel
HL41_06235	ENOG4105K63	Thioredoxin
HL41_06255	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
HL41_06260	ENOG4105XA0	heptosyltransferase ii
HL41_06265	ENOG4107UKG	Glycosyl transferase, family 4
HL41_06270	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
HL41_06305	ENOG4106WTF	Glycosyl transferase, family 2
HL41_06315	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
HL41_06410	ENOG4105EJ7	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity)
HL41_06425	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
HL41_06440	ENOG41081QV	Universal stress protein
HL41_06460	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
HL41_06470	ENOG4105CAY	ferredoxin--nadp reductase
HL41_06475	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
HL41_06490	ENOG4105EHZ	conserved protein UCP016719
HL41_06500	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
HL41_06505	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
HL41_06510	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
HL41_06520	ENOG4105DX0	Hemolysin A
HL41_06525	ENOG4105D0S	secretion protein (HlyD
HL41_06530	ENOG4105CJ1	ABC, transporter
HL41_06535	ENOG4107QWP	ABC-2 type transporter
HL41_06540	ENOG4105CMI	transporter
HL41_06550	ENOG4105CRE	cytochrome C
HL41_06555	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
HL41_06560	ENOG4108UUM	single-stranded DNA-binding protein
HL41_06585	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
HL41_06595	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
HL41_06605	ENOG4108I0Q	anthranilate phosphoribosyltransferase
HL41_06625	ENOG41082X2	rubredoxin
HL41_06640	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
HL41_06645	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HL41_06660	ENOG4105D7Q	type ii secretion system
HL41_06665	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HL41_06670	ENOG4105D49	3-dehydroquinate synthase
HL41_06680	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
HL41_06710	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
HL41_06720	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
HL41_06730	ENOG4105C3G	gtp-binding protein
HL41_06765	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
HL41_06780	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
HL41_06800	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
HL41_06805	ENOG4107QI6	Cysteine desulfurase
HL41_06810	ENOG4106K5Q	Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity)
HL41_06815	ENOG4105CRE	cytochrome C
HL41_06820	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HL41_07160	ENOG4105DFF	Rod shape-determining protein mreb
HL41_07175	ENOG4105CHM	Aminotransferase
HL41_07180	ENOG4105CZA	synthase
HL41_07185	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HL41_07195	ENOG4105DDQ	anthranilate synthase
HL41_07200	ENOG4105CRQ	synthase (Component I)
HL41_07205	ENOG4105CUT	histidyl-tRNA synthetase
HL41_07210	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
HL41_07215	ENOG4105CE1	Ferrous iron transport protein b
HL41_07220	ENOG4105DC7	peptidase M24
HL41_07235	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
HL41_07240	ENOG41076CZ	activating enzyme
HL41_07260	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HL41_07290	ENOG4108ZZK	Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity)
HL41_07295	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
HL41_07300	ENOG4105CQB	FAD linked oxidase domain protein
HL41_07305	ENOG4105DAA	L-lactate
HL41_07315	ENOG4105CD5	CoA-binding domain protein
HL41_07335	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
HL41_07340	ENOG4105DDK	oxidoreductase, beta subunit
HL41_07345	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HL41_07350	ENOG4108HM5	NADH-ubiquinone oxidoreductase chain 49kDa
HL41_07360	ENOG4105D65	subunit l
HL41_07365	ENOG4108JPZ	Monovalent cation H antiporter subunit D
HL41_07370	ENOG4105C47	NADH ubiquinone oxidoreductase 20 kda subunit
HL41_07400	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HL41_07410	ENOG4107Y3Y	amidohydrolase
HL41_07415	ENOG4105DKF	Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity)
HL41_07420	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
HL41_07435	ENOG4105C6T	cysteine synthase
HL41_07450	ENOG4105CD3	dihydroorotase
HL41_07455	ENOG4105CXT	aspartate transcarbamylase
HL41_07475	ENOG4105C0H	protease
HL41_07485	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
HL41_07490	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HL41_07505	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
HL41_07515	ENOG4105DJV	ribulose-phosphate 3-epimerase
HL41_07530	ENOG4105ERG	peptidase m48, ste24p
HL41_07570	ENOG4108C5W	FIST N domain
HL41_07610	ENOG4105DZA	Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity)
HL41_07615	ENOG4107VP5	methyltetrahydrofolate corrinoid iron-sulfur protein methyltransferase
HL41_07620	ENOG4105EYX	Acetyl-CoA decarbonylase synthase complex subunit gamma
HL41_07625	ENOG4105E8X	CO dehydrogenase acetyl-CoA synthase complex beta subunit
HL41_07630	ENOG4106HYN	CO dehydrogenase acetyl-CoA synthase delta subunit
HL41_07655	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
HL41_07660	ENOG4105CKU	formyltetrahydrofolate synthetase
HL41_07690	ENOG4105CHC	glucokinase (EC 2.7.1.2)
HL41_07695	ENOG4105K8N	protein family UPF0079, ATPase
HL41_07700	ENOG4105C1V	Peptidase, M16
HL41_07755	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
HL41_07760	ENOG4105ZHF	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
HL41_07770	ENOG4105C0D	helicase
HL41_07795	ENOG4105VXP	Protein of unknown function DUF86
HL41_07815	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
HL41_07830	ENOG4107QMV	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
HL41_07870	ENOG4105C8Q	Methyl-accepting chemotaxis
HL41_07885	ENOG4107SBE	Glycosyl transferase (Group 1
HL41_07905	ENOG4105CPK	Glycosyl transferase (Group 1
HL41_07910	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
HL41_07925	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HL41_07935	ENOG4107QUV	Domain protein
HL41_07960	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
HL41_07965	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
HL41_07970	ENOG4105D49	3-dehydroquinate synthase
HL41_07975	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
HL41_07980	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HL41_07985	ENOG4108WS4	fmn reductase
HL41_07995	ENOG4108UXE	Protein tyrosine phosphatase
HL41_08010	ENOG4107XTP	(EAL) domain protein
HL41_08020	ENOG4105C0B	DNA polymerase III (alpha subunit)
HL41_08025	ENOG41090A1	ferritin
HL41_08030	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HL41_08035	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
HL41_08060	ENOG41082DI	50s ribosomal protein l31
HL41_08065	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HL41_08095	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HL41_08125	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
HL41_08130	ENOG4108YZY	peptidylprolyl cis-trans isomerase
HL41_08145	ENOG4105WPN	DNA integration recombination invertion protein
HL41_08160	ENOG4107RFY	SbcCD D subunit
HL41_08170	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
HL41_08190	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
HL41_08200	ENOG4105C8Y	Acetylornithine aminotransferase
HL41_08205	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HL41_08215	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
HL41_08225	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HL41_08235	ENOG4105BZU	Histidine kinase
HL41_08245	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
HL41_08250	ENOG4105FDP	GntR family transcriptional regulator
HL41_08275	ENOG4107YZX	Universal stress protein
HL41_08280	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
HL41_08310	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
HL41_08315	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
HL41_08320	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
HL41_08330	ENOG4105C8U	phosphate abc transporter
HL41_08335	ENOG4107QMV	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
HL41_08340	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HL41_08345	ENOG4105BZU	Histidine kinase
HL41_08350	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HL41_08355	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
HL41_08360	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
HL41_08375	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
HL41_08385	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HL41_08395	ENOG4107S2Z	UPF0761 membrane protein
HL41_08405	ENOG4107QIZ	NADH dehydrogenase
HL41_08410	ENOG4107QHI	-hydrogenase
HL41_08435	ENOG4108IJ0	Aspartate ammonia-lyase
HL41_08485	ENOG4107QN1	sodium solute
HL41_08490	ENOG41062QD	Membrane
HL41_08495	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
HL41_08520	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
HL41_08530	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HL41_08535	ENOG4105DFH	Transport of potassium into the cell (By similarity)
HL41_08555	ENOG4105DZS	Phenylacetate-CoA ligase
HL41_08565	ENOG4105DZS	Phenylacetate-CoA ligase
HL41_08570	ENOG4105HD0	Transcriptional regulator of molybdate metabolism, LysR family
HL41_08580	ENOG4107WHI	formate dehydrogenase, beta subunit
HL41_08605	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
HL41_08620	ENOG4108SX7	hmc operon protein 5
HL41_08625	ENOG4107QQM	Cysteine-rich domain
HL41_08630	ENOG4105F1C	cytochrome c
HL41_08640	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
HL41_08645	ENOG4105CJ5	hydrogenase 2 b cytochrome subunit
HL41_08650	ENOG4108J2R	molybdopterin oxidoreductase
HL41_08655	ENOG4105QAX	Iron-sulfur
HL41_08660	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HL41_08665	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HL41_08670	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HL41_08675	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HL41_08680	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HL41_08685	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
HL41_08695	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HL41_08700	ENOG4108JPZ	Monovalent cation H antiporter subunit D
HL41_08715	ENOG4108JPZ	Monovalent cation H antiporter subunit D
HL41_08730	ENOG4105C8Q	Methyl-accepting chemotaxis
HL41_08735	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HL41_08740	ENOG4105BZU	Histidine kinase
HL41_08750	ENOG4105C3M	thioredoxin reductase
HL41_08760	ENOG4105C45	hydrogenase expression formation protein (HypE)
HL41_08765	ENOG4105WMM	Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity)
HL41_08815	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HL41_08830	ENOG4105C83	adenylosuccinate lyase
HL41_08845	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
HL41_08850	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
HL41_08855	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
HL41_08860	ENOG4105CDU	Replicative dna helicase
HL41_08870	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
HL41_08890	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
HL41_08900	ENOG4105EAH	synthase
HL41_08905	ENOG4107RIQ	Sulfate adenylate transferase
HL41_08955	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HL41_08960	ENOG4105WDJ	50S ribosomal protein L33
HL41_08980	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
HL41_08990	ENOG4108VZM	50s ribosomal protein L10
HL41_08995	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
HL41_09000	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HL41_09005	ENOG4107QR0	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HL41_09010	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
HL41_09015	ENOG4105C0H	protease
HL41_09020	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
HL41_09025	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
HL41_09030	ENOG4105MJ2	Competence protein
HL41_09035	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
HL41_09045	ENOG4105F7V	ErfK ybiS ycfS ynhG family protein
HL41_09055	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
HL41_09060	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
HL41_09065	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
HL41_09070	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
HL41_09090	ENOG4108I9K	permease protein
HL41_09095	ENOG4108HWH	(ABC) transporter
HL41_09105	ENOG4105EET	magnesium chelatase
HL41_09110	ENOG4105EET	magnesium chelatase
HL41_09135	ENOG4105C2X	Arabinose 5-phosphate isomerase
HL41_09165	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
HL41_09175	ENOG4107S1E	Beta-lactamase