locus-tag	class	description
HL41_00040	COG0306	phosphate transporter
HL41_00070	COG0606	chelatase, subunit chli
HL41_00075	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HL41_00080	COG0356	it plays a direct role in the translocation of protons across the membrane
HL41_00100	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HL41_00120	COG1959	2 iron, 2 sulfur cluster binding
HL41_00145	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HL41_00150	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HL41_00165	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HL41_00170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HL41_00175	COG0698	ribose 5-phosphate isomerase
HL41_00180	COG0736	holo-[acyl-carrier-protein] synthase activity
HL41_00185	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HL41_00185	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HL41_00200	COG5000	phosphorelay sensor kinase activity
HL41_00220	COG0811	peptide transport
HL41_00225	COG0848	biopolymer transport protein
HL41_00240	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HL41_00245	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HL41_00245	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HL41_00275	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HL41_00280	COG0613	PHP domain protein
HL41_00285	COG0504	CTP synthase activity
HL41_00310	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HL41_00320	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
HL41_00330	COG1278	Cold shock
HL41_00340	COG3290	protein histidine kinase activity
HL41_00345	COG4974	Belongs to the 'phage' integrase family
HL41_00355	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HL41_00360	COG0693	protein deglycase activity
HL41_00375	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HL41_00390	COG3706	GGDEF domain
HL41_00395	COG2835	tetraacyldisaccharide 4'-kinase activity
HL41_00405	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HL41_00415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HL41_00415	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HL41_00420	COG0537	adenosine 5'-monophosphoramidase activity
HL41_00425	COG0511	ligase activity, forming carbon-carbon bonds
HL41_00430	COG0439	Biotin carboxylase
HL41_00435	COG4752	Belongs to the RNA methyltransferase TrmD family
HL41_00435	COG0336	Belongs to the RNA methyltransferase TrmD family
HL41_00440	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HL41_00445	COG1837	Belongs to the UPF0109 family
HL41_00450	COG0228	four-way junction DNA binding
HL41_00455	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HL41_00460	COG3108	Peptidase M15
HL41_00465	COG2989	Protein conserved in bacteria
HL41_00475	COG0235	Class ii aldolase
HL41_00480	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HL41_00485	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HL41_00490	COG0019	diaminopimelate decarboxylase activity
HL41_00530	COG1815	bacterial-type flagellum-dependent cell motility
HL41_00535	COG1558	bacterial-type flagellum-dependent cell motility
HL41_00540	COG1677	Flagellar hook-basal body complex protein FliE
HL41_00545	COG1766	The M ring may be actively involved in energy transduction
HL41_00550	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HL41_00560	COG1157	protein secretion by the type III secretion system
HL41_00580	COG0735	belongs to the Fur family
HL41_00590	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HL41_00595	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HL41_00605	COG0165	Argininosuccinate lyase
HL41_00645	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
HL41_00650	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HL41_00660	COG0009	L-threonylcarbamoyladenylate synthase
HL41_00670	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HL41_00680	COG0805	protein transport
HL41_00685	COG0047	phosphoribosylformylglycinamidine synthase activity
HL41_00710	COG0628	permease
HL41_00725	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HL41_00730	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HL41_00735	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HL41_00740	COG0193	aminoacyl-tRNA hydrolase activity
HL41_00750	COG0519	Catalyzes the synthesis of GMP from XMP
HL41_00765	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HL41_00775	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HL41_00825	COG1362	aminopeptidase activity
HL41_00835	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HL41_00860	COG0751	glycine-tRNA ligase activity
HL41_00865	COG0752	glycyl-tRNA synthetase alpha subunit
HL41_00870	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HL41_00895	COG0688	phosphatidylethanolamine metabolic process
HL41_00905	COG2052	Domain of unknown function (DUF370)
HL41_00910	COG0194	GDP metabolic process
HL41_00915	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HL41_00935	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HL41_00945	COG1136	(ABC) transporter
HL41_00950	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HL41_00960	COG4786	Flagellar basal body rod
HL41_00980	COG1706	bacterial-type flagellum-dependent cell motility
HL41_00995	COG4786	Flagellar basal body rod
HL41_00995	COG1256	bacterial-type flagellum assembly
HL41_01005	COG0823	Involved in the tonB-independent uptake of proteins
HL41_01010	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HL41_01015	COG0436	Aminotransferase
HL41_01030	COG1234	tRNA 3'-trailer cleavage
HL41_01065	COG0772	Belongs to the SEDS family
HL41_01080	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HL41_01085	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HL41_01090	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HL41_01095	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HL41_01100	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HL41_01105	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HL41_01110	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HL41_01125	COG1160	GTP binding
HL41_01145	COG1227	inorganic diphosphatase activity
HL41_01150	COG0157	Belongs to the NadC ModD family
HL41_01155	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HL41_01160	COG0443	Heat shock 70 kDa protein
HL41_01165	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HL41_01185	COG0018	arginyl-trna synthetase
HL41_01195	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HL41_01200	COG2920	part of a sulfur-relay system
HL41_01210	COG1960	acyl-CoA dehydrogenase activity
HL41_01215	COG2086	electron transfer activity
HL41_01220	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HL41_01230	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HL41_01235	COG0084	hydrolase, TatD family'
HL41_01245	COG1121	(ABC) transporter
HL41_01250	COG3956	TIGRFAM MazG family protein
HL41_01255	COG0066	3-isopropylmalate dehydratase activity
HL41_01260	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HL41_01265	COG1570	exodeoxyribonuclease VII activity
HL41_01290	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HL41_01295	COG0151	Belongs to the GarS family
HL41_01300	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HL41_01305	COG4537	Required for transformation and DNA binding
HL41_01315	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HL41_01315	COG0731	radical SAM domain protein
HL41_01320	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HL41_01330	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HL41_01335	COG0052	Belongs to the universal ribosomal protein uS2 family
HL41_01340	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HL41_01345	COG0528	UMP kinase activity
HL41_01350	COG0233	cytoplasmic translational termination
HL41_01355	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HL41_01370	COG1181	Belongs to the D-alanine--D-alanine ligase family
HL41_01385	COG1242	4 iron, 4 sulfur cluster binding
HL41_01390	COG0579	oxidoreductase
HL41_01400	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HL41_01405	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HL41_01415	COG0758	DNA mediated transformation
HL41_01430	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HL41_01440	COG0335	large ribosomal subunit rRNA binding
HL41_01445	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HL41_01450	COG0792	nuclease activity
HL41_01465	COG0460	homoserine dehydrogenase
HL41_01475	COG3599	regulation of cell shape
HL41_01475	COG1418	mRNA catabolic process
HL41_01520	COG1418	mRNA catabolic process
HL41_01525	COG1692	metallophosphoesterase
HL41_01530	COG0242	peptide deformylase activity
HL41_01535	COG0857	belongs to the CobB CobQ family
HL41_01540	COG0402	S-adenosylhomocysteine deaminase activity
HL41_01565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HL41_01570	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HL41_01580	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HL41_01585	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HL41_01590	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HL41_01650	COG1797	cobyrinic acid a,c-diamide synthase activity
HL41_01670	COG2703	oxygen carrier activity
HL41_01715	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HL41_01725	COG0343	queuine tRNA-ribosyltransferase activity
HL41_01730	COG0436	Aminotransferase
HL41_01760	COG1309	transcriptional regulator
HL41_01775	COG1538	Outer membrane efflux protein
HL41_01790	COG0497	DNA recombination
HL41_01815	COG2204	response regulator
HL41_01820	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
HL41_01830	COG0473	3-isopropylmalate dehydrogenase activity
HL41_01845	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HL41_01850	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HL41_01855	COG0445	tRNA wobble uridine modification
HL41_01870	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HL41_01880	COG0482	sulfurtransferase activity
HL41_01915	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HL41_01935	COG0535	radical SAM domain protein
HL41_01940	COG0138	bifunctional purine biosynthesis protein purh
HL41_01950	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HL41_01955	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HL41_01960	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HL41_01965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HL41_01970	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HL41_01980	COG1796	DNA polymerase
HL41_01980	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HL41_01985	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HL41_02005	COG0187	DNA topoisomerase II activity
HL41_02010	COG0592	DNA-directed DNA polymerase activity
HL41_02015	COG0492	ferredoxin-NADP+ reductase activity
HL41_02020	COG1619	proteins homologs of microcin C7 resistance protein MccF
HL41_02030	COG2264	protein methyltransferase activity
HL41_02040	COG1605	Chorismate mutase
HL41_02040	COG0077	Prephenate dehydratase
HL41_02050	COG0195	Participates in both transcription termination and antitermination
HL41_02055	COG0779	Required for maturation of 30S ribosomal subunits
HL41_02115	COG0067	glutamate synthase
HL41_02120	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HL41_02120	COG0069	glutamate synthase activity
HL41_02130	COG0174	glutamine synthetase
HL41_02145	COG0347	Belongs to the P(II) protein family
HL41_02150	COG0004	ammonium transporteR
HL41_02165	COG2059	Chromate
HL41_02180	COG0531	amino acid
HL41_02205	COG1763	Mo-molybdopterin cofactor biosynthetic process
HL41_02210	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HL41_02220	COG1013	pyruvate-flavodoxin oxidoreductase activity
HL41_02225	COG0674	pyruvate-flavodoxin oxidoreductase activity
HL41_02245	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HL41_02255	COG0444	Belongs to the ABC transporter superfamily
HL41_02270	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HL41_02275	COG0277	FAD linked oxidase domain protein
HL41_02290	COG2204	response regulator
HL41_02300	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HL41_02335	COG0166	Belongs to the GPI family
HL41_02340	COG0113	porphobilinogen synthase activity
HL41_02345	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HL41_02360	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HL41_02370	COG0735	belongs to the Fur family
HL41_02375	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HL41_02385	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HL41_02390	COG2414	aldehyde ferredoxin oxidoreductase
HL41_02395	COG1294	oxidase, subunit
HL41_02400	COG1271	oxidase subunit
HL41_02415	COG3300	MHYT domain
HL41_02415	COG5001	Diguanylate cyclase
HL41_02420	COG0469	pyruvate kinase activity
HL41_02435	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HL41_02475	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
HL41_02485	COG0310	cobalt ion transport
HL41_02490	COG0310	cobalt ion transport
HL41_02495	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HL41_02510	COG0701	Predicted permease
HL41_02520	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HL41_02530	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HL41_02550	COG0484	heat shock protein binding
HL41_02560	COG2201	protein-glutamate methylesterase activity
HL41_02590	COG1191	sigma factor activity
HL41_02595	COG0455	bacterial-type flagellum organization
HL41_02600	COG1419	protein localization to endoplasmic reticulum
HL41_02605	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HL41_02610	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HL41_02615	COG1684	flagellar biosynthetic protein fliR
HL41_02620	COG1987	bacterial-type flagellum assembly
HL41_02625	COG1338	Plays a role in the flagellum-specific transport system
HL41_02660	COG1519	Transferase
HL41_02670	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HL41_02690	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HL41_02700	COG1489	DNA binding
HL41_02715	COG0730	response to heat
HL41_02735	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HL41_02745	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HL41_02750	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HL41_02765	COG1137	ATPase activity
HL41_02790	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HL41_02800	COG0840	transmembrane signaling receptor activity
HL41_02815	COG0840	transmembrane signaling receptor activity
HL41_02825	COG0840	transmembrane signaling receptor activity
HL41_02825	COG5278	phosphoserine phosphatase activity
HL41_02830	COG1090	epimerase
HL41_02840	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HL41_02845	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HL41_02850	COG0803	Belongs to the bacterial solute-binding protein 9 family
HL41_02875	COG0719	Fe-S assembly protein
HL41_02880	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HL41_02885	COG5001	Diguanylate cyclase
HL41_02885	COG5002	protein histidine kinase activity
HL41_02925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HL41_02930	COG1253	flavin adenine dinucleotide binding
HL41_02935	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HL41_02940	COG0163	prenyltransferase activity
HL41_02945	COG0328	RNA-DNA hybrid ribonuclease activity
HL41_02950	COG0840	transmembrane signaling receptor activity
HL41_02980	COG0835	chemotaxis
HL41_02985	COG2198	Histidine kinase
HL41_02985	COG0643	Histidine kinase
HL41_02990	COG0697	spore germination
HL41_02995	COG1187	pseudouridine synthase activity
HL41_03005	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HL41_03015	COG0037	tRNA processing
HL41_03030	COG0704	Plays a role in the regulation of phosphate uptake
HL41_03040	COG0481	GTPase activity
HL41_03050	COG1131	(ABC) transporter
HL41_03080	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HL41_03085	COG0439	Biotin carboxylase
HL41_03090	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HL41_03105	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HL41_03120	COG0268	Binds directly to 16S ribosomal RNA
HL41_03130	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HL41_03135	COG1355	regulation of microtubule-based process
HL41_03140	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HL41_03145	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HL41_03145	COG3266	domain, Protein
HL41_03175	COG2095	MarC family integral membrane protein
HL41_03180	COG0531	amino acid
HL41_03190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HL41_03195	COG1136	(ABC) transporter
HL41_03195	COG0577	efflux transmembrane transporter activity
HL41_03200	COG1136	(ABC) transporter
HL41_03200	COG0577	efflux transmembrane transporter activity
HL41_03205	COG0577	efflux transmembrane transporter activity
HL41_03205	COG1136	(ABC) transporter
HL41_03225	COG5001	Diguanylate cyclase
HL41_03225	COG3300	MHYT domain
HL41_03230	COG1196	nuclear chromosome segregation
HL41_03240	COG0525	valine-tRNA ligase activity
HL41_03245	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HL41_03305	COG0602	queuosine metabolic process
HL41_03330	COG1253	flavin adenine dinucleotide binding
HL41_03335	COG1253	flavin adenine dinucleotide binding
HL41_03370	COG0864	Transcriptional regulator
HL41_03375	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HL41_03380	COG0557	exoribonuclease II activity
HL41_03390	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HL41_03395	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HL41_03405	COG0756	dUTP diphosphatase activity
HL41_03420	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HL41_03425	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HL41_03440	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HL41_03460	COG0590	tRNA wobble adenosine to inosine editing
HL41_03470	COG2003	Belongs to the UPF0758 family
HL41_03480	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HL41_03485	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HL41_03490	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HL41_03500	COG0137	argininosuccinate synthase activity
HL41_03505	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HL41_03510	COG0671	phosphoesterase, PA-phosphatase related
HL41_03515	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HL41_03520	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HL41_03545	COG0105	UTP biosynthetic process
HL41_03550	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HL41_03560	COG0542	response to heat
HL41_03575	COG0456	acetyltransferase
HL41_03590	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HL41_03595	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HL41_03600	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HL41_03635	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HL41_03645	COG0181	hydroxymethylbilane synthase activity
HL41_03655	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HL41_03660	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HL41_03680	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HL41_03685	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HL41_03690	COG0180	Tryptophanyl-tRNA synthetase
HL41_03705	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HL41_03720	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HL41_03730	COG0513	Belongs to the DEAD box helicase family
HL41_03735	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HL41_03740	COG0521	Mo-molybdopterin cofactor biosynthetic process
HL41_03750	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HL41_03770	COG0425	Belongs to the sulfur carrier protein TusA family
HL41_03790	COG2721	sulfolactate sulfo-lyase activity
HL41_03795	COG2721	sulfolactate sulfo-lyase activity
HL41_03805	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HL41_03820	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HL41_03840	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HL41_03845	COG2067	long-chain fatty acid transport protein
HL41_03855	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HL41_03860	COG2045	Belongs to the ComB family
HL41_03915	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HL41_03970	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HL41_03970	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HL41_03975	COG0174	glutamine synthetase
HL41_03995	COG0489	protein tyrosine kinase activity
HL41_04010	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HL41_04015	COG1516	flagellar protein fliS
HL41_04045	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HL41_04050	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HL41_04055	COG0134	indole-3-glycerol-phosphate synthase activity
HL41_04060	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HL41_04070	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HL41_04075	COG0706	membrane insertase activity
HL41_04085	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HL41_04090	COG0351	phosphomethylpyrimidine kinase
HL41_04095	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HL41_04100	COG0154	amidase activity
HL41_04105	COG1475	DNA binding
HL41_04115	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HL41_04135	COG1546	Belongs to the CinA family
HL41_04135	COG1058	Belongs to the CinA family
HL41_04140	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HL41_04150	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HL41_04150	COG0475	glutathione-regulated potassium exporter activity
HL41_04155	COG3706	GGDEF domain
HL41_04165	COG4974	Belongs to the 'phage' integrase family
HL41_04175	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HL41_04210	COG0730	response to heat
HL41_04240	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HL41_04250	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HL41_04265	COG0495	leucyl-tRNA aminoacylation
HL41_04275	COG0538	isocitrate dehydrogenase activity
HL41_04310	COG1980	fructose-bisphosphate aldolase activity
HL41_04315	COG2257	FlhB HrpN YscU SpaS Family
HL41_04320	COG0509	glycine decarboxylation via glycine cleavage system
HL41_04350	COG1490	D-aminoacyl-tRNA deacylase activity
HL41_04360	COG0438	transferase activity, transferring glycosyl groups
HL41_04365	COG0438	transferase activity, transferring glycosyl groups
HL41_04375	COG1877	trehalose-phosphatase activity
HL41_04415	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HL41_04425	COG0501	Belongs to the peptidase M48B family
HL41_04430	COG1132	(ABC) transporter
HL41_04440	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HL41_04445	COG1530	ribonuclease E activity
HL41_04460	COG3301	Polysulphide reductase, NrfD
HL41_04475	COG1333	cytochrome c biogenesis protein
HL41_04480	COG0793	Belongs to the peptidase S41A family
HL41_04485	COG1994	Peptidase M50
HL41_04515	COG5001	Diguanylate cyclase
HL41_04520	COG0778	Nitroreductase
HL41_04545	COG1663	tetraacyldisaccharide 4'-kinase activity
HL41_04560	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HL41_04570	COG0284	orotidine-5'-phosphate decarboxylase activity
HL41_04575	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HL41_04580	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HL41_04580	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HL41_04585	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HL41_04615	COG3706	GGDEF domain
HL41_04625	COG0459	protein refolding
HL41_04630	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HL41_04640	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HL41_04670	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HL41_04680	COG2204	response regulator
HL41_04685	COG4191	Histidine kinase
HL41_04690	COG1216	Glycosyl transferase, family 2
HL41_04690	COG0463	Glycosyl transferase, family 2
HL41_04695	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HL41_04705	COG1605	Chorismate mutase
HL41_04705	COG0287	Prephenate dehydrogenase
HL41_04710	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HL41_04715	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HL41_04725	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HL41_04735	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HL41_04740	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HL41_04745	COG0307	riboflavin synthase, alpha
HL41_04755	COG0135	phosphoribosylanthranilate isomerase activity
HL41_04780	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HL41_04790	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HL41_04805	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HL41_04810	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HL41_04815	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HL41_04830	COG0275	rRNA processing
HL41_04835	COG2001	Belongs to the MraZ family
HL41_04880	COG4974	Belongs to the 'phage' integrase family
HL41_04935	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HL41_04940	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HL41_04945	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HL41_04950	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HL41_04955	COG0138	bifunctional purine biosynthesis protein purh
HL41_04960	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HL41_04975	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HL41_04980	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HL41_04995	COG1127	ABC transporter
HL41_05005	COG0129	dihydroxy-acid dehydratase activity
HL41_05010	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HL41_05015	COG1758	RNA polymerase activity
HL41_05020	COG0484	heat shock protein binding
HL41_05025	COG0315	cyclic pyranopterin monophosphate synthase activity
HL41_05030	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HL41_05035	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HL41_05040	COG2221	Nitrite and sulphite reductase 4Fe-4S
HL41_05040	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HL41_05050	COG1187	pseudouridine synthase activity
HL41_05060	COG0517	IMP dehydrogenase activity
HL41_05080	COG0750	zinc metalloprotease
HL41_05085	COG1214	PFAM Peptidase M22, glycoprotease
HL41_05090	COG0601	transmembrane transport
HL41_05095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HL41_05105	COG0586	Pfam SNARE associated Golgi protein
HL41_05110	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HL41_05135	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HL41_05145	COG0298	carbon dioxide binding
HL41_05150	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HL41_05155	COG1192	Involved in chromosome partitioning
HL41_05160	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HL41_05170	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HL41_05175	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HL41_05195	COG2252	PERMEase
HL41_05210	COG0557	exoribonuclease II activity
HL41_05240	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HL41_05275	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HL41_05280	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HL41_05285	COG0740	serine-type endopeptidase activity
HL41_05290	COG0544	peptidyl-prolyl cis-trans isomerase activity
HL41_05305	COG0202	RNA polymerase activity
HL41_05310	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HL41_05315	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HL41_05320	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HL41_05330	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HL41_05340	COG0563	adenylate kinase activity
HL41_05345	COG0201	protein transport
HL41_05350	COG0200	Binds to the 23S rRNA
HL41_05355	COG1841	ribosomal large subunit assembly
HL41_05360	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HL41_05365	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HL41_05375	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HL41_05380	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HL41_05385	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HL41_05390	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HL41_05395	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HL41_05400	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HL41_05405	COG0255	Belongs to the universal ribosomal protein uL29 family
HL41_05410	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HL41_05415	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HL41_05420	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HL41_05425	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HL41_05430	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HL41_05435	COG0089	rRNA binding
HL41_05440	COG0088	Forms part of the polypeptide exit tunnel
HL41_05445	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HL41_05450	COG0051	transcription antitermination factor activity, RNA binding
HL41_05455	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HL41_05460	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HL41_05465	COG0049	tRNA binding
HL41_05470	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HL41_05475	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HL41_05500	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HL41_05505	COG2131	deaminase
HL41_05510	COG0484	heat shock protein binding
HL41_05525	COG0778	Nitroreductase
HL41_05530	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HL41_05535	COG2078	PFAM AMMECR1 domain protein
HL41_05550	COG0778	Nitroreductase
HL41_05555	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HL41_05560	COG2078	PFAM AMMECR1 domain protein
HL41_05580	COG0484	heat shock protein binding
HL41_05585	COG0527	aspartate kinase activity
HL41_05590	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HL41_05600	COG0215	cysteine-tRNA ligase activity
HL41_05610	COG0131	Imidazoleglycerol-phosphate dehydratase
HL41_05615	COG0101	tRNA pseudouridine synthase activity
HL41_05620	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HL41_05625	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HL41_05630	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HL41_05645	COG0330	HflC and HflK could
HL41_05655	COG0028	Belongs to the TPP enzyme family
HL41_05660	COG0440	acetolactate synthase activity
HL41_05670	COG0805	protein transport
HL41_05675	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HL41_05695	COG2221	Nitrite and sulphite reductase 4Fe-4S
HL41_05700	COG2884	Cell division ATP-binding protein ftsE
HL41_05740	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HL41_05755	COG1028	Short-chain dehydrogenase reductase Sdr
HL41_05760	COG0432	Pfam Uncharacterised protein family UPF0047
HL41_05770	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HL41_05835	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HL41_05840	COG0217	transcriptional regulatory protein
HL41_05855	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HL41_05855	COG1773	rubredoxin
HL41_05875	COG0237	dephospho-CoA kinase activity
HL41_05880	COG0564	pseudouridine synthase activity
HL41_05900	COG0505	Belongs to the CarA family
HL41_05920	COG0426	domain, Protein
HL41_05935	COG1773	rubredoxin
HL41_05945	COG2033	superoxide reductase activity
HL41_05960	COG0072	phenylalanine-tRNA ligase activity
HL41_05965	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HL41_05970	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HL41_05975	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HL41_06025	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HL41_06025	COG1918	ferrous iron import across plasma membrane
HL41_06030	COG1918	ferrous iron import across plasma membrane
HL41_06040	COG3706	GGDEF domain
HL41_06050	COG0450	alkyl hydroperoxide reductase
HL41_06065	COG1592	Rubrerythrin
HL41_06070	COG1749	Flagellar hook protein flgE
HL41_06075	COG1749	Flagellar hook protein flgE
HL41_06090	COG1007	ATP synthesis coupled electron transport
HL41_06105	COG0713	ATP synthesis coupled electron transport
HL41_06120	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HL41_06125	COG0649	NAD binding
HL41_06135	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HL41_06145	COG0437	4 iron, 4 sulfur cluster binding
HL41_06155	COG1832	CoA-binding protein
HL41_06160	COG0149	triose-phosphate isomerase activity
HL41_06160	COG0126	phosphoglycerate kinase activity
HL41_06165	COG0126	phosphoglycerate kinase activity
HL41_06165	COG0149	triose-phosphate isomerase activity
HL41_06185	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HL41_06185	COG0574	Belongs to the PEP-utilizing enzyme family
HL41_06190	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HL41_06195	COG0419	ATPase involved in DNA repair
HL41_06200	COG0746	molybdenum cofactor guanylyltransferase activity
HL41_06220	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HL41_06225	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HL41_06230	COG0811	peptide transport
HL41_06235	COG3118	belongs to the thioredoxin family
HL41_06255	COG0585	pseudouridine synthase activity
HL41_06260	COG0859	PFAM glycosyl transferase family 9
HL41_06265	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HL41_06315	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HL41_06410	COG1151	hydroxylamine reductase activity
HL41_06420	COG1088	dTDP-glucose 4,6-dehydratase activity
HL41_06440	COG0589	response to stress
HL41_06460	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HL41_06460	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HL41_06470	COG0492	ferredoxin-NADP+ reductase activity
HL41_06475	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HL41_06490	COG3876	Protein conserved in bacteria
HL41_06500	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HL41_06505	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HL41_06510	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HL41_06520	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HL41_06525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HL41_06530	COG1131	(ABC) transporter
HL41_06535	COG0842	Transport permease protein
HL41_06540	COG0842	Transport permease protein
HL41_06550	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HL41_06560	COG0629	single-stranded DNA binding
HL41_06585	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HL41_06595	COG0148	phosphopyruvate hydratase activity
HL41_06605	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HL41_06625	COG1773	rubredoxin
HL41_06640	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HL41_06645	COG2890	protein-(glutamine-N5) methyltransferase activity
HL41_06660	COG1459	type II secretion system
HL41_06665	COG0517	IMP dehydrogenase activity
HL41_06665	COG0516	GMP reductase activity
HL41_06670	COG0248	Ppx GppA phosphatase
HL41_06670	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HL41_06675	COG0616	signal peptide processing
HL41_06680	COG0539	negative regulation of cytoplasmic translation
HL41_06710	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HL41_06720	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HL41_06730	COG0012	GTP binding
HL41_06765	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HL41_06780	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HL41_06800	COG1472	Belongs to the glycosyl hydrolase 3 family
HL41_06805	COG1104	cysteine desulfurase activity
HL41_06810	COG1110	DNA topoisomerase II activity
HL41_06815	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HL41_06820	COG0517	IMP dehydrogenase activity
HL41_06820	COG0516	GMP reductase activity
HL41_07160	COG1077	Cell shape determining protein MreB Mrl
HL41_07175	COG0436	Aminotransferase
HL41_07180	COG1260	myo-inositol-1-phosphate synthase
HL41_07185	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HL41_07195	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HL41_07195	COG0512	Glutamine amidotransferase of anthranilate synthase
HL41_07210	COG0446	pyridine nucleotide-disulphide oxidoreductase
HL41_07215	COG1918	ferrous iron import across plasma membrane
HL41_07215	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HL41_07220	COG0006	proline dipeptidase activity
HL41_07235	COG0352	thiamine-phosphate diphosphorylase activity
HL41_07240	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HL41_07255	COG5000	phosphorelay sensor kinase activity
HL41_07260	COG2204	response regulator
HL41_07295	COG0247	lactate metabolic process
HL41_07300	COG0277	FAD linked oxidase domain protein
HL41_07305	COG1620	l-lactate permease
HL41_07315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HL41_07315	COG1042	CoA-binding domain protein
HL41_07315	COG0045	succinate-CoA ligase (ADP-forming) activity
HL41_07320	COG0857	belongs to the CobB CobQ family
HL41_07335	COG0674	pyruvate-flavodoxin oxidoreductase activity
HL41_07340	COG1013	pyruvate-flavodoxin oxidoreductase activity
HL41_07365	COG0651	ATP synthesis coupled electron transport
HL41_07370	COG3260	NADH ubiquinone oxidoreductase 20
HL41_07400	COG2226	methyltransferase
HL41_07410	COG0402	S-adenosylhomocysteine deaminase activity
HL41_07415	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HL41_07420	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HL41_07435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HL41_07450	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HL41_07455	COG0540	Belongs to the ATCase OTCase family
HL41_07460	COG1611	Belongs to the LOG family
HL41_07475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HL41_07485	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HL41_07490	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HL41_07505	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HL41_07515	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HL41_07530	COG4783	chaperone-mediated protein folding
HL41_07560	COG2217	Heavy metal translocating P-type atpase
HL41_07570	COG3287	FIST C domain
HL41_07605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HL41_07610	COG1469	GTP cyclohydrolase I activity
HL41_07655	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HL41_07660	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HL41_07695	COG0802	atpase or kinase
HL41_07700	COG0612	Peptidase, M16
HL41_07755	COG1518	maintenance of DNA repeat elements
HL41_07760	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HL41_07770	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HL41_07795	COG2361	Protein of unknown function DUF86
HL41_07815	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HL41_07830	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HL41_07870	COG0840	transmembrane signaling receptor activity
HL41_07885	COG0438	transferase activity, transferring glycosyl groups
HL41_07905	COG0438	transferase activity, transferring glycosyl groups
HL41_07910	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HL41_07925	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HL41_07935	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HL41_07960	COG0133	tryptophan synthase activity
HL41_07965	COG0159	tryptophan synthase activity
HL41_07975	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HL41_07980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HL41_07985	COG0655	NAD(P)H dehydrogenase (quinone) activity
HL41_07995	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HL41_08010	COG2200	EAL domain
HL41_08020	COG0587	DNA-directed DNA polymerase activity
HL41_08025	COG1528	Iron-storage protein
HL41_08030	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HL41_08030	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HL41_08035	COG0556	nucleotide-excision repair
HL41_08060	COG0254	rRNA binding
HL41_08065	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HL41_08095	COG0085	RNA polymerase activity
HL41_08125	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HL41_08140	COG0475	glutathione-regulated potassium exporter activity
HL41_08145	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HL41_08160	COG0420	3'-5' exonuclease activity
HL41_08170	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HL41_08190	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HL41_08200	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HL41_08205	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HL41_08215	COG0303	'Molybdopterin
HL41_08225	COG2204	response regulator
HL41_08235	COG4191	Histidine kinase
HL41_08245	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HL41_08245	COG0574	Belongs to the PEP-utilizing enzyme family
HL41_08250	COG2188	Transcriptional regulator
HL41_08275	COG0589	response to stress
HL41_08280	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HL41_08280	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HL41_08290	COG0589	response to stress
HL41_08310	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HL41_08315	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HL41_08320	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HL41_08335	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HL41_08340	COG0745	RESPONSE REGULATOR receiver
HL41_08345	COG5002	protein histidine kinase activity
HL41_08350	COG4206	TonB-dependent receptor
HL41_08355	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HL41_08360	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HL41_08375	COG0437	4 iron, 4 sulfur cluster binding
HL41_08385	COG0552	protein localization to endoplasmic reticulum
HL41_08395	COG1295	ribonuclease BN
HL41_08435	COG1027	Aspartate ammonia-lyase
HL41_08485	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HL41_08490	COG3162	membrane
HL41_08495	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HL41_08520	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HL41_08530	COG0442	prolyl-tRNA aminoacylation
HL41_08535	COG3158	transport of potassium into the cell
HL41_08555	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HL41_08565	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HL41_08570	COG1910	domain protein
HL41_08580	COG0437	4 iron, 4 sulfur cluster binding
HL41_08605	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HL41_08620	COG2181	nitrate reductase activity
HL41_08625	COG0247	lactate metabolic process
HL41_08630	COG0484	heat shock protein binding
HL41_08640	COG0437	4 iron, 4 sulfur cluster binding
HL41_08640	COG3064	Membrane
HL41_08645	COG5557	Pfam Polysulphide reductase, NrfD
HL41_08655	COG0437	4 iron, 4 sulfur cluster binding
HL41_08660	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HL41_08665	COG0649	NAD binding
HL41_08670	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HL41_08675	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HL41_08685	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HL41_08695	COG0713	ATP synthesis coupled electron transport
HL41_08700	COG0651	ATP synthesis coupled electron transport
HL41_08715	COG0651	ATP synthesis coupled electron transport
HL41_08735	COG2204	response regulator
HL41_08740	COG4191	Histidine kinase
HL41_08750	COG0492	ferredoxin-NADP+ reductase activity
HL41_08765	COG0375	protein maturation
HL41_08770	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HL41_08815	COG0546	phosphoglycolate phosphatase activity
HL41_08830	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HL41_08845	COG0360	Binds together with S18 to 16S ribosomal RNA
HL41_08850	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HL41_08855	COG0359	binds to the 23S rRNA
HL41_08860	COG0305	Participates in initiation and elongation during chromosome replication
HL41_08870	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HL41_08890	COG1074	ATP-dependent DNA helicase activity
HL41_08900	COG0142	geranyltranstransferase activity
HL41_08905	COG2046	Belongs to the sulfate adenylyltransferase family
HL41_08925	COG1053	succinate dehydrogenase
HL41_08955	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HL41_08960	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HL41_08980	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HL41_08995	COG0222	ribosome binding
HL41_09000	COG0085	RNA polymerase activity
HL41_09005	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HL41_09010	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HL41_09015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HL41_09020	COG1254	Belongs to the acylphosphatase family
HL41_09025	COG2195	Cleaves the N-terminal amino acid of tripeptides
HL41_09030	COG1040	competence protein
HL41_09035	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HL41_09035	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HL41_09045	COG3034	peptidoglycan biosynthetic process
HL41_09055	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HL41_09060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HL41_09065	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HL41_09070	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HL41_09090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HL41_09095	COG1120	ATPase activity
HL41_09105	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HL41_09110	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HL41_09110	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HL41_09135	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HL41_09135	COG0517	IMP dehydrogenase activity
HL41_09165	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HL41_09175	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HL41_09180	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HL41_09220	COG3259	Nickel-dependent hydrogenase