locus-tag	class	description
TOPB45_0001	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
TOPB45_0002	ENOG4105CQB	FAD linked oxidase domain protein
TOPB45_0003	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
TOPB45_0004	ENOG4105E4C	Lytic transglycosylase catalytic
TOPB45_0005	ENOG4105D64	Mechanosensitive ion channel
TOPB45_0012	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
TOPB45_0014	ENOG4108YZG	isomerase
TOPB45_0016	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
TOPB45_0019	ENOG4105CSA	Coproporphyrinogen iii oxidase
TOPB45_0020	ENOG41060K3	Methyltransferase
TOPB45_0022	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
TOPB45_0024	ENOG4105C5R	Aminotransferase
TOPB45_0025	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
TOPB45_0026	ENOG4105DC1	bifunctional purine biosynthesis protein purh
TOPB45_0027	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
TOPB45_0030	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
TOPB45_0031	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
TOPB45_0034	ENOG4105DHJ	ABC, transporter
TOPB45_0036	ENOG4105C01	Dihydroxy-acid dehydratase
TOPB45_0037	ENOG41083MR	nifu domain-containing protein
TOPB45_0038	ENOG41084BP	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
TOPB45_0039	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
TOPB45_0040	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
TOPB45_0042	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
TOPB45_0043	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
TOPB45_0046	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
TOPB45_0047	ENOG4105DZP	Membrane-associated zinc metalloprotease
TOPB45_0048	ENOG41072GX	Peptidase M22 Glycoprotease
TOPB45_0050	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
TOPB45_0054	ENOG4108JUA	Transcriptional regulator
TOPB45_0056	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
TOPB45_0057	ENOG4105K88	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
TOPB45_0058	ENOG4108ZC9	flagellar basal-body rod protein flgc
TOPB45_0059	ENOG4108844	flagellar hook-basal body complex protein fliE
TOPB45_0060	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
TOPB45_0061	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
TOPB45_0066	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
TOPB45_0067	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
TOPB45_0069	ENOG4105K70	DNA-binding protein
TOPB45_0071	ENOG4105F4G	Membrane
TOPB45_0074	ENOG4107Z7S	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
TOPB45_0075	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
TOPB45_0076	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
TOPB45_0077	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
TOPB45_0079	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
TOPB45_0083	ENOG41084CW	50S ribosomal protein L32
TOPB45_0084	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
TOPB45_0085	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
TOPB45_0086	ENOG4105BZE	flagellar hook protein, FlgE
TOPB45_0087	ENOG4105BZE	flagellar hook protein, FlgE
TOPB45_0088	ENOG410822I	Flagellar hook capping protein
TOPB45_0090	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
TOPB45_0091	ENOG4105C8S	subunit m
TOPB45_0092	ENOG4105D65	subunit l
TOPB45_0093	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
TOPB45_0095	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
TOPB45_0096	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
TOPB45_0097	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
TOPB45_0098	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TOPB45_0099	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
TOPB45_0100	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TOPB45_0101	ENOG4105QAX	Iron-sulfur
TOPB45_0103	ENOG4105K4P	CoA-binding domain protein
TOPB45_0104	ENOG4105CP7	Triose-phosphate isomerase
TOPB45_0105	ENOG4105BZA	Phosphoglycerate kinase
TOPB45_0106	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
TOPB45_0109	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
TOPB45_0110	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
TOPB45_0112	ENOG41080AZ	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
TOPB45_0113	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
TOPB45_0117	ENOG4105E63	Pfam:DUF178
TOPB45_0119	ENOG4105K63	Thioredoxin
TOPB45_0120	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TOPB45_0122	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
TOPB45_0123	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
TOPB45_0124	ENOG4105XA0	heptosyltransferase ii
TOPB45_0126	ENOG4107QYG	anthranilate phosphoribosyltransferase
TOPB45_0127	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
TOPB45_0128	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
TOPB45_0129	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
TOPB45_0130	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
TOPB45_0131	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
TOPB45_0132	ENOG4107RFY	SbcCD D subunit
TOPB45_0133	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
TOPB45_0137	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
TOPB45_0138	ENOG4105C8Y	Acetylornithine aminotransferase
TOPB45_0139	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
TOPB45_0144	ENOG4105Y7X	Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity)
TOPB45_0145	ENOG4105CVR	type I restriction-modification system
TOPB45_0148	ENOG4105EKX	Restriction modification system DNA (Specificity
TOPB45_0151	ENOG4105DZR	Type I site-specific deoxyribonuclease
TOPB45_0152	ENOG41080FJ	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
TOPB45_0154	ENOG4105CNW	domain protein
TOPB45_0157	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
TOPB45_0158	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
TOPB45_0159	ENOG4105C34	Pseudouridine synthase
TOPB45_0161	ENOG4105DR5	peptidase
TOPB45_0162	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
TOPB45_0163	ENOG4107QR0	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
TOPB45_0164	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
TOPB45_0165	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
TOPB45_0166	ENOG4108VZM	50s ribosomal protein L10
TOPB45_0167	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
TOPB45_0168	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
TOPB45_0169	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
TOPB45_0170	ENOG410683Z	Preprotein translocase SecE subunit
TOPB45_0171	ENOG4105WDJ	50S ribosomal protein L33
TOPB45_0172	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
TOPB45_0174	ENOG4105EWK	phytoene
TOPB45_0179	ENOG4107RIQ	Sulfate adenylate transferase
TOPB45_0180	ENOG4105EAH	synthase
TOPB45_0182	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
TOPB45_0183	ENOG4107TVK	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
TOPB45_0186	ENOG4107YZX	Universal stress protein
TOPB45_0187	ENOG4105CDU	Replicative dna helicase
TOPB45_0188	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
TOPB45_0189	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
TOPB45_0190	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
TOPB45_0191	ENOG4105M6F	mutator MutT protein
TOPB45_0192	ENOG4105C83	adenylosuccinate lyase
TOPB45_0194	ENOG4105BZU	Histidine kinase
TOPB45_0196	ENOG4105C2X	Arabinose 5-phosphate isomerase
TOPB45_0197	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
TOPB45_0201	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
TOPB45_0202	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
TOPB45_0203	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
TOPB45_0204	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
TOPB45_0205	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
TOPB45_0207	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
TOPB45_0209	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
TOPB45_0210	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
TOPB45_0218	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
TOPB45_0219	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
TOPB45_0221	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
TOPB45_0222	ENOG4107QJE	Chromosome Partitioning Protein
TOPB45_0225	ENOG4105U5Y	Transcriptional regulator
TOPB45_0228	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
TOPB45_0230	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
TOPB45_0232	ENOG4106H78	methyltransferase
TOPB45_0234	ENOG4106DSS	Tartrate dehydratase subunit alpha
TOPB45_0236	ENOG4107QI6	Cysteine desulfurase
TOPB45_0237	ENOG4106K5Q	Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity)
TOPB45_0238	ENOG4105CRE	cytochrome C
TOPB45_0239	ENOG4108JQC	penicillin-binding protein 1A
TOPB45_0240	ENOG4105BZU	Histidine kinase
TOPB45_0242	ENOG410801I	Peptidyl-prolyl cis-trans isomerase
TOPB45_0243	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
TOPB45_0246	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
TOPB45_0247	ENOG4105CRE	cytochrome C
TOPB45_0249	ENOG4108NGH	radical SAM domain protein
TOPB45_0252	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
TOPB45_0253	ENOG41082DI	50s ribosomal protein l31
TOPB45_0254	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
TOPB45_0255	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
TOPB45_0257	ENOG4105C0H	protease
TOPB45_0259	ENOG410826D	Involved in DNA repair and RecF pathway recombination (By similarity)
TOPB45_0260	ENOG4108URH	decarboxylase
TOPB45_0261	ENOG4105CXT	aspartate transcarbamylase
TOPB45_0262	ENOG4105CD3	dihydroorotase
TOPB45_0263	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
TOPB45_0264	ENOG4107N1Q	ErfK YbiS YcfS YnhG family protein
TOPB45_0265	ENOG4105C6T	cysteine synthase
TOPB45_0269	ENOG4105DKF	Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity)
TOPB45_0270	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
TOPB45_0272	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
TOPB45_0273	ENOG4105BZU	Histidine kinase
TOPB45_0275	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
TOPB45_0276	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
TOPB45_0279	ENOG4107R76	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
TOPB45_0283	ENOG4105C3G	gtp-binding protein
TOPB45_0285	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
TOPB45_0286	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
TOPB45_0288	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
TOPB45_0289	ENOG4105CW7	secretion protein, HlyD family
TOPB45_0294	ENOG4105C89	phosphohexose isomerase
TOPB45_0295	ENOG4105D52	delta-aminolevulinic acid dehydratase
TOPB45_0296	ENOG4105K6T	rare lipoprotein A
TOPB45_0297	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
TOPB45_0298	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
TOPB45_0300	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
TOPB45_0301	ENOG4105MJ2	Competence protein
TOPB45_0302	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
TOPB45_0303	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
TOPB45_0307	ENOG4105D0U	Arsenite-activated ATPase (ArsA)
TOPB45_0308	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
TOPB45_0309	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
TOPB45_0312	ENOG41076CZ	activating enzyme
TOPB45_0313	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
TOPB45_0319	ENOG4105BZU	Histidine kinase
TOPB45_0336	ENOG4105ER6	polysaccharide biosynthesis protein
TOPB45_0341	ENOG4105H63	Glycosyl transferase, family 2
TOPB45_0350	ENOG4105CPK	Glycosyl transferase (Group 1
TOPB45_0354	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
TOPB45_0365	ENOG4107V1M	polysaccharide export protein
TOPB45_0367	ENOG4105DFF	Rod shape-determining protein mreb
TOPB45_0369	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TOPB45_0370	ENOG4105CHM	Aminotransferase
TOPB45_0372	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
TOPB45_0374	ENOG4105DDQ	anthranilate synthase
TOPB45_0375	ENOG4105CRQ	synthase (Component I)
TOPB45_0376	ENOG4105CUT	histidyl-tRNA synthetase
TOPB45_0377	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
TOPB45_0378	ENOG4105CE1	Ferrous iron transport protein b
TOPB45_0379	ENOG4105DC7	peptidase M24
TOPB45_0380	ENOG4105EVY	Uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent (By similarity)
TOPB45_0383	ENOG4105FJH	Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity)
TOPB45_0387	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
TOPB45_0388	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
TOPB45_0389	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
TOPB45_0392	ENOG4105CAY	ferredoxin--nadp reductase
TOPB45_0393	ENOG4105EYX	Acetyl-CoA decarbonylase synthase complex subunit gamma
TOPB45_0394	ENOG4105E8X	CO dehydrogenase acetyl-CoA synthase complex beta subunit
TOPB45_0395	ENOG4106HYN	CO dehydrogenase acetyl-CoA synthase delta subunit
TOPB45_0398	ENOG4105CJG	carbon-monoxide dehydrogenase catalytic subunit
TOPB45_0399	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
TOPB45_0400	ENOG4105CKU	formyltetrahydrofolate synthetase
TOPB45_0401	ENOG4105CMR	udp-glucose 4-epimerase
TOPB45_0402	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
TOPB45_0403	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
TOPB45_0406	ENOG41081QV	Universal stress protein
TOPB45_0408	ENOG4105DAP	Nicotinate phosphoribosyltransferase
TOPB45_0409	ENOG4105C1V	Peptidase, M16
TOPB45_0410	ENOG4105K8N	protein family UPF0079, ATPase
TOPB45_0411	ENOG4105CHC	glucokinase (EC 2.7.1.2)
TOPB45_0413	ENOG4105KCK	Peptidoglycan-associated lipoprotein
TOPB45_0416	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
TOPB45_0419	ENOG4105DIN	metallophosphoesterase
TOPB45_0420	ENOG4105ERH	Fumarylacetoacetate hydrolase
TOPB45_0421	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
TOPB45_0422	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
TOPB45_0424	ENOG4105BZU	Histidine kinase
TOPB45_0425	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
TOPB45_0426	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
TOPB45_0427	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
TOPB45_0428	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
TOPB45_0429	ENOG4105EHZ	conserved protein UCP016719
TOPB45_0431	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TOPB45_0432	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
TOPB45_0433	ENOG4105C0B	DNA polymerase III (alpha subunit)
TOPB45_0435	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
TOPB45_0436	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
TOPB45_0438	ENOG4105D0S	secretion protein (HlyD
TOPB45_0439	ENOG4105CJ1	ABC, transporter
TOPB45_0440	ENOG4105CJ1	ABC, transporter
TOPB45_0441	ENOG4105CMI	transporter
TOPB45_0445	ENOG4105ERG	peptidase m48, ste24p
TOPB45_0449	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
TOPB45_0450	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
TOPB45_0451	ENOG4105D49	3-dehydroquinate synthase
TOPB45_0452	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
TOPB45_0453	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
TOPB45_0454	ENOG4107QW4	alcohol dehydrogenase
TOPB45_0458	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
TOPB45_0459	ENOG4105BZU	Histidine kinase
TOPB45_0460	ENOG4105BZU	Histidine kinase
TOPB45_0461	ENOG4105DZA	Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity)
TOPB45_0463	ENOG4107RSS	Hydrogenase accessory protein HypB
TOPB45_0464	ENOG4105C45	hydrogenase expression formation protein (HypE)
TOPB45_0465	ENOG4105WMM	Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity)
TOPB45_0466	ENOG4108USZ	hydrogenase
TOPB45_0470	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
TOPB45_0471	ENOG4105BZU	Histidine kinase
TOPB45_0472	ENOG4108Z6B	deaminase
TOPB45_0473	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
TOPB45_0474	ENOG4105W5Q	DNA repair protein (RadC
TOPB45_0476	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
TOPB45_0477	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
TOPB45_0482	ENOG41088YS	Glycosyl transferase (Group 1
TOPB45_0486	ENOG4105CDH	Citrulline--aspartate ligase
TOPB45_0487	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
TOPB45_0488	ENOG4105D1E	Undecaprenyl pyrophosphate phosphatase
TOPB45_0490	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
TOPB45_0492	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
TOPB45_0494	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
TOPB45_0495	ENOG4105VF7	tolerance protein
TOPB45_0496	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
TOPB45_0498	ENOG4107WHI	formate dehydrogenase, beta subunit
TOPB45_0500	ENOG4105HD0	Transcriptional regulator of molybdate metabolism, LysR family
TOPB45_0501	ENOG4107S2Z	UPF0761 membrane protein
TOPB45_0503	ENOG4105CM2	brancheD-chain amino acid aminotransferase
TOPB45_0506	ENOG4105DVY	radical SAM domain protein
TOPB45_0510	ENOG4105CPK	Glycosyl transferase (Group 1
TOPB45_0512	ENOG4107SBE	Glycosyl transferase (Group 1
TOPB45_0515	ENOG41061AI	Protein of unknown function (DUF2905)
TOPB45_0517	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
TOPB45_0518	ENOG4108UKJ	Cdp-alcohol phosphatidyltransferase
TOPB45_0519	ENOG4105WPN	DNA integration recombination invertion protein
TOPB45_0522	ENOG41090R7	Ferric uptake
TOPB45_0524	ENOG4107YIW	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
TOPB45_0525	ENOG4107QMV	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
TOPB45_0526	ENOG4105C8U	phosphate abc transporter
TOPB45_0527	ENOG4105E2Z	phosphate ABC transporter (Permease
TOPB45_0528	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
TOPB45_0529	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
TOPB45_0530	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
TOPB45_0532	ENOG4105DTN	riboflavin biosynthesis protein ribF
TOPB45_0533	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
TOPB45_0536	ENOG4105CNW	domain protein
TOPB45_0538	ENOG4105VCQ	rubredoxin
TOPB45_0539	ENOG4105VCQ	rubredoxin
TOPB45_0540	ENOG4105VCQ	rubredoxin
TOPB45_0541	ENOG4105MAX	Superoxide reductase
TOPB45_0543	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
TOPB45_0544	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
TOPB45_0545	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
TOPB45_0546	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
TOPB45_0547	ENOG4105VJV	50s ribosomal protein L35
TOPB45_0548	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
TOPB45_0549	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
TOPB45_0550	ENOG4108N3W	hemolysin secretion protein
TOPB45_0554	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
TOPB45_0556	ENOG4105D3R	alkyl hydroperoxide reductase
TOPB45_0559	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
TOPB45_0561	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
TOPB45_0563	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
TOPB45_0564	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
TOPB45_0567	ENOG410890F	Dynamin family
TOPB45_0569	ENOG4105W3S	hemerythrin-like, metal-binding protein
TOPB45_0573	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
TOPB45_0576	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
TOPB45_0578	ENOG4105CDY	transcriptional regulatory protein
TOPB45_0580	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
TOPB45_0584	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
TOPB45_0585	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
TOPB45_0586	ENOG4105DK0	Indole-3-glycerol phosphate synthase
TOPB45_0587	ENOG41085QA	50S ribosomal protein l34
TOPB45_0588	ENOG41084AH	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
TOPB45_0589	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
TOPB45_0590	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
TOPB45_0592	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
TOPB45_0595	ENOG4105DWF	phosphomethylpyrimidine kinase
TOPB45_0596	ENOG41081AP	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
TOPB45_0597	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
TOPB45_0598	ENOG4105FA0	parb-like partition protein
TOPB45_0599	ENOG4107UU3	sucrose-phosphate synthase (EC 2.4.1.14)
TOPB45_0602	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
TOPB45_0605	ENOG4105M7V	2'-5' rna ligase
TOPB45_0606	ENOG4107TH8	cina domain protein
TOPB45_0607	ENOG4108ZAI	phosphatidylglycerophosphatase a
TOPB45_0609	ENOG4105ECP	epimerase
TOPB45_0610	ENOG4107SVH	Potassium channel protein
TOPB45_0611	ENOG4107YZX	Universal stress protein
TOPB45_0614	ENOG4105CB5	ATP-dependent DNA helicase recG
TOPB45_0616	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
TOPB45_0619	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
TOPB45_0620	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
TOPB45_0621	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
TOPB45_0622	ENOG4108R6K	riboflavin synthase, subunit alpha
TOPB45_0625	ENOG4107QXV	Phosphate transporter
TOPB45_0629	ENOG4105BZU	Histidine kinase
TOPB45_0630	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
TOPB45_0633	ENOG4105CD5	CoA-binding domain protein
TOPB45_0635	ENOG4107SYB	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
TOPB45_0636	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
TOPB45_0637	ENOG4107QW4	alcohol dehydrogenase
TOPB45_0638	ENOG4105C5I	Dehydrogenase
TOPB45_0639	ENOG4105WCJ	ec 1.1.1.193
TOPB45_0642	ENOG41067SE	Tetr family transcriptional regulator
TOPB45_0645	ENOG4105DZS	Phenylacetate-CoA ligase
TOPB45_0647	ENOG4105DZS	Phenylacetate-CoA ligase
TOPB45_0649	ENOG4105DAA	L-lactate
TOPB45_0654	ENOG4105HHA	aminodeoxychorismate lyase
TOPB45_0655	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
TOPB45_0656	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
TOPB45_0657	ENOG4105CSH	Transporter
TOPB45_0660	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
TOPB45_0662	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
TOPB45_0663	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
TOPB45_0665	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
TOPB45_0666	ENOG4105BZU	Histidine kinase
TOPB45_0667	ENOG4105YVM	Phosphoesterase, PA-phosphatase related
TOPB45_0669	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
TOPB45_0674	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
TOPB45_0675	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
TOPB45_0676	ENOG4105D00	flagellar biosynthetic protein flhB
TOPB45_0677	ENOG4107NFR	Fructose-1,6-bisphosphatase
TOPB45_0679	ENOG4105SG9	biopolymer transport protein, ExbD
TOPB45_0681	ENOG4105CHM	Aminotransferase
TOPB45_0684	ENOG4107Y7W	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity)
TOPB45_0685	ENOG4105CNU	cell division protein FtsK
TOPB45_0688	ENOG4105C22	threonyL-tRNA synthetase
TOPB45_0689	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
TOPB45_0690	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
TOPB45_0692	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
TOPB45_0693	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TOPB45_0694	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
TOPB45_0695	ENOG4105DJV	ribulose-phosphate 3-epimerase
TOPB45_0697	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
TOPB45_0698	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
TOPB45_0701	ENOG4105CGK	Exodeoxyribonuclease III
TOPB45_0704	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
TOPB45_0706	ENOG4105K5M	30s ribosomal protein S16
TOPB45_0707	ENOG4105VB6	UPF0109 protein
TOPB45_0708	ENOG410836E	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
TOPB45_0709	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
TOPB45_0712	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
TOPB45_0713	ENOG4106063	Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit
TOPB45_0715	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
TOPB45_0716	ENOG4108UJD	30S ribosomal protein S9
TOPB45_0717	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
TOPB45_0718	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
TOPB45_0719	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
TOPB45_0721	ENOG4105C8N	cysteinyl-tRNA synthetase
TOPB45_0722	ENOG4107U53	septum site-determining protein minD
TOPB45_0723	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
TOPB45_0724	ENOG4105CFH	Aspartokinase
TOPB45_0729	ENOG4107R7I	amino acid
TOPB45_0734	ENOG4105CJ1	ABC, transporter
TOPB45_0736	ENOG4105NBF	ammecr1 domain protein
TOPB45_0738	ENOG4108RCM	Nitroreductase
TOPB45_0740	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
TOPB45_0741	ENOG4105DVC	DnaJ domain protein
TOPB45_0742	ENOG4108UK2	deaminase
TOPB45_0743	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
TOPB45_0744	ENOG4105CKK	Glycosyl transferase, family 2
TOPB45_0748	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
TOPB45_0749	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
TOPB45_0750	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
TOPB45_0751	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
TOPB45_0752	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
TOPB45_0753	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
TOPB45_0754	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
TOPB45_0756	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TOPB45_0757	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
TOPB45_0758	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
TOPB45_0759	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
TOPB45_0760	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
TOPB45_0761	ENOG41082SA	50s ribosomal protein l29
TOPB45_0762	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
TOPB45_0763	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
TOPB45_0764	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
TOPB45_0765	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TOPB45_0766	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
TOPB45_0767	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
TOPB45_0768	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
TOPB45_0769	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
TOPB45_0770	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
TOPB45_0771	ENOG4105VPB	50S ribosomal protein L30
TOPB45_0772	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
TOPB45_0773	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
TOPB45_0774	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
TOPB45_0776	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
TOPB45_0778	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TOPB45_0779	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
TOPB45_0780	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
TOPB45_0781	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
TOPB45_0782	ENOG4108ZT0	50S ribosomal protein l17
TOPB45_0783	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
TOPB45_0784	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
TOPB45_0785	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
TOPB45_0786	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
TOPB45_0787	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
TOPB45_0788	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
TOPB45_0789	ENOG4108UMR	transcriptional regulator AsnC family
TOPB45_0790	ENOG4107SH3	glycosyl transferase, family 39
TOPB45_0792	ENOG4105ES5	Histidine kinase
TOPB45_0793	ENOG4105C2M	dna polymerase I
TOPB45_0794	ENOG41085TX	30S ribosomal protein S21
TOPB45_0796	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
TOPB45_0797	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
TOPB45_0798	ENOG4108UMR	transcriptional regulator AsnC family
TOPB45_0800	ENOG4105D0M	Protease HtpX homolog
TOPB45_0817	ENOG4105C0H	protease
TOPB45_0821	ENOG4107S90	membrAne
TOPB45_0822	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
TOPB45_0823	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
TOPB45_0824	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
TOPB45_0833	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
TOPB45_0834	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
TOPB45_0835	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
TOPB45_0837	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
TOPB45_0838	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
TOPB45_0839	ENOG4105D7Q	type ii secretion system
TOPB45_0841	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
TOPB45_0843	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
TOPB45_0844	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
TOPB45_0845	ENOG4105FA2	dna polymerase iii
TOPB45_0850	ENOG4105E3H	phosphoglycerate mutase
TOPB45_0851	ENOG4105M8K	biopolymer transport protein
TOPB45_0852	ENOG4105M15	transport protein ExbD
TOPB45_0857	ENOG4108VKV	Monofunctional biosynthetic peptidoglycan transglycosylase
TOPB45_0859	ENOG4107RYT	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity)
TOPB45_0869	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
TOPB45_0872	ENOG4105DZP	Membrane-associated zinc metalloprotease
TOPB45_0875	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
TOPB45_0879	ENOG4107WJT	it plays a direct role in the translocation of protons across the membrane (By similarity)
TOPB45_0880	ENOG4105VH4	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
TOPB45_0881	ENOG4105C0P	Mg chelatase subunit ChlI
TOPB45_0882	ENOG4108Y5D	Inherit from COG: cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
TOPB45_0885	ENOG4105DPX	Hydrogenase, large subunit
TOPB45_0886	ENOG4105E3S	small subunit
TOPB45_0888	ENOG4105KBH	arsR family transcriptional regulator
TOPB45_0893	ENOG4105EHI	Phosphonate ABC transporter, periplasmic
TOPB45_0894	ENOG4105BZU	Histidine kinase
TOPB45_0895	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
TOPB45_0896	ENOG4105QAX	Iron-sulfur
TOPB45_0897	ENOG4108J2R	molybdopterin oxidoreductase
TOPB45_0902	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
TOPB45_0903	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
TOPB45_0906	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
TOPB45_0907	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
TOPB45_0908	ENOG4105WH1	Two component transcriptional regulator luxr family
TOPB45_0914	ENOG4105P8Q	Curli production assembly transport component CsgG
TOPB45_0915	ENOG4105IQJ	Involved in biosynthesis of the thiamine precursor thiazole (By similarity)
TOPB45_0916	ENOG4107QHF	type ii secretion system protein e
TOPB45_0917	ENOG4105D7Q	type ii secretion system
TOPB45_0927	ENOG4105DFU	Cell wall formation (By similarity)
TOPB45_0930	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
TOPB45_0931	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
TOPB45_0935	ENOG4108V6E	Cell division protein mraZ
TOPB45_0936	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
TOPB45_0939	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
TOPB45_0940	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
TOPB45_0941	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
TOPB45_0942	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
TOPB45_0943	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
TOPB45_0944	ENOG4105DFU	Cell wall formation (By similarity)
TOPB45_0945	ENOG4105D4A	Cell wall formation (By similarity)
TOPB45_0947	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
TOPB45_0948	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
TOPB45_0951	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
TOPB45_0955	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
TOPB45_0956	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
TOPB45_0957	ENOG4105DF0	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity)
TOPB45_0959	ENOG4105CJR	Integral membrane protein (MviN
TOPB45_0960	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
TOPB45_0962	ENOG4105K64	Glycosyl transferase, family 2
TOPB45_0969	ENOG4105BZU	Histidine kinase
TOPB45_0970	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
TOPB45_0973	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
TOPB45_0975	ENOG4105CKX	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP
TOPB45_0978	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
TOPB45_0979	ENOG4108ZEY	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
TOPB45_0980	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
TOPB45_0981	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
TOPB45_0982	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
TOPB45_0983	ENOG4105VFF	UPF0102 protein
TOPB45_0992	ENOG4105C6E	dna polymerase iii
TOPB45_0993	ENOG410816I	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
TOPB45_0994	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
TOPB45_0996	ENOG4105C79	DNA protecting protein DprA
TOPB45_0997	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
TOPB45_0998	ENOG4107QNG	Phosphoribosylglycinamide synthetase
TOPB45_0999	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
TOPB45_1000	ENOG4105VFE	sira family
TOPB45_1002	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
TOPB45_1006	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
TOPB45_1007	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
TOPB45_1008	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
TOPB45_1010	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
TOPB45_1011	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
TOPB45_1013	ENOG4108Z4T	Peptidase M50
TOPB45_1014	ENOG4105CN1	protease
TOPB45_1015	ENOG4105CE9	30S ribosomal protein S2
TOPB45_1016	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
TOPB45_1017	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
TOPB45_1018	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
TOPB45_1020	ENOG4105KNE	Phosphatidate cytidylyltransferase
TOPB45_1022	ENOG4105CPF	Cell wall formation (By similarity)
TOPB45_1024	ENOG4105K3G	Periplasmic Protein
TOPB45_1025	ENOG4105N5T	Radical SAM Protein
TOPB45_1029	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
TOPB45_1032	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
TOPB45_1033	ENOG4105C4R	Atp-dependent dna helicase
TOPB45_1036	ENOG4105CAS	nag kinase
TOPB45_1037	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
TOPB45_1039	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
TOPB45_1045	ENOG4105C8V	SAICAR synthetase
TOPB45_1048	ENOG4105C0D	helicase
TOPB45_1062	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
TOPB45_1067	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
TOPB45_1068	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
TOPB45_1069	ENOG4108EE5	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
TOPB45_1070	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
TOPB45_1072	ENOG4105CUB	amino acid
TOPB45_1073	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
TOPB45_1075	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
TOPB45_1077	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
TOPB45_1079	ENOG4107EEM	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
TOPB45_1080	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
TOPB45_1081	ENOG41074MP	UPF0103 Mediator of ErbB2-driven cell motility-containing protein
TOPB45_1082	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
TOPB45_1083	ENOG4105BZU	Histidine kinase
TOPB45_1108	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
TOPB45_1109	ENOG410695F	Crispr-associated protein, Csm1 family
TOPB45_1111	ENOG4108W8W	CRISPR-associated RAMP protein, Csm3 family
TOPB45_1113	ENOG4105G15	CRISPR-associated RAMP protein, Csm5 family
TOPB45_1118	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
TOPB45_1122	ENOG4105VG5	Membrane
TOPB45_1123	ENOG4105FE9	pseudouridine synthase
TOPB45_1124	ENOG4105DFH	Transport of potassium into the cell (By similarity)
TOPB45_1125	ENOG4105BZU	Histidine kinase
TOPB45_1128	ENOG4108NWD	Cytochrome
TOPB45_1131	ENOG4105C31	Tryptophanyl-tRNA synthetase
TOPB45_1132	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
TOPB45_1133	ENOG4105EBH	Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity)
TOPB45_1137	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
TOPB45_1138	ENOG4105C3F	Signal peptidase i
TOPB45_1141	ENOG4107R56	PP-loop domain protein
TOPB45_1143	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
TOPB45_1145	ENOG4105FE9	pseudouridine synthase
TOPB45_1147	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
TOPB45_1148	ENOG41083W3	Multi-copper polyphenol oxidoreductase laccase
TOPB45_1149	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
TOPB45_1150	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
TOPB45_1152	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
TOPB45_1153	ENOG4105MRR	Transcriptional regulator (By similarity)
TOPB45_1154	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
TOPB45_1156	ENOG4105CIH	Imidazole acetol-phosphate transaminase
TOPB45_1157	ENOG4105DIW	FeS assembly protein SUFB
TOPB45_1161	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
TOPB45_1163	ENOG4105C03	ribonuclease
TOPB45_1164	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
TOPB45_1165	ENOG4105XA0	heptosyltransferase ii
TOPB45_1166	ENOG4105BZ1	(ABC) transporter
TOPB45_1167	ENOG4105D0M	Protease HtpX homolog
TOPB45_1169	ENOG41071I4	Phosphatidylserine decarboxylase proenzyme
TOPB45_1170	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
TOPB45_1171	ENOG4105KC4	UPF0296 protein
TOPB45_1172	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
TOPB45_1173	ENOG4105C2N	RNA methyltransferase TrmH family group 3
TOPB45_1180	ENOG4105BZU	Histidine kinase
TOPB45_1181	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
TOPB45_1182	ENOG4105XFK	Ferrous iron transport protein A
TOPB45_1183	ENOG4105CE1	Ferrous iron transport protein b
TOPB45_1185	ENOG4107YU2	histidine triad (hIT) protein
TOPB45_1186	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
TOPB45_1187	ENOG4105MA4	psp1 domain protein
TOPB45_1188	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
TOPB45_1190	ENOG4105W49	UPF0434 protein
TOPB45_1192	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
TOPB45_1193	ENOG4108JVH	Protein of unknown function DUF43
TOPB45_1195	ENOG4105BZU	Histidine kinase
TOPB45_1196	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
TOPB45_1197	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
TOPB45_1203	ENOG4105D3S	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
TOPB45_1205	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
TOPB45_1207	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
TOPB45_1212	ENOG4105E4G	Type IV pilus
TOPB45_1213	ENOG4107QXI	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity)
TOPB45_1214	ENOG4105VIE	preprotein translocase, subunit YajC
TOPB45_1215	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
TOPB45_1216	ENOG4105CHM	Aminotransferase
TOPB45_1219	ENOG410645S	MarR family Transcriptional regulator
TOPB45_1226	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
TOPB45_1227	ENOG4105ZHF	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
TOPB45_1240	ENOG4105VFE	sira family
TOPB45_1251	ENOG4108JEB	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
TOPB45_1252	ENOG4105DUN	Mediates zinc uptake. May also transport other divalent cations (By similarity)
TOPB45_1256	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
TOPB45_1257	ENOG4105C5F	glutamine synthetase
TOPB45_1258	ENOG4108JUA	Transcriptional regulator
TOPB45_1259	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
TOPB45_1260	ENOG4108YZA	Nitrogen regulatory protein pii
TOPB45_1262	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
TOPB45_1263	ENOG4105CEY	Amp-dependent synthetase and ligase
TOPB45_1264	ENOG410688J	Ferredoxin
TOPB45_1266	ENOG4105D1F	ATP-binding protein
TOPB45_1267	ENOG4105C9A	Phoh family
TOPB45_1269	ENOG4105VZ9	UPF0235 protein
TOPB45_1270	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
TOPB45_1271	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
TOPB45_1272	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
TOPB45_1273	ENOG4108DUY	carboxyl transferase
TOPB45_1275	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
TOPB45_1276	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
TOPB45_1278	ENOG4105CAK	Cell division ATP-binding protein ftsE
TOPB45_1282	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
TOPB45_1283	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
TOPB45_1284	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
TOPB45_1285	ENOG4105EM7	Selenocysteine-specific translation elongation factor
TOPB45_1286	ENOG4105DAN	ATP-dependent protease
TOPB45_1287	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
TOPB45_1288	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
TOPB45_1289	ENOG4105DXN	mazG family
TOPB45_1290	ENOG4105FDK	ABC transporter
TOPB45_1291	ENOG4105FAV	ABC, transporter
TOPB45_1292	ENOG4105F8V	Hydrolase, tatD family
TOPB45_1293	ENOG4105C9M	aspartyl-trna synthetase
TOPB45_1295	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
TOPB45_1296	ENOG4105C10	Electron transfer flavoprotein
TOPB45_1297	ENOG4105BZJ	Electron transfer flavoprotein
TOPB45_1298	ENOG4105C1G	acyl-Coa dehydrogenase
TOPB45_1299	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
TOPB45_1300	ENOG4105CEY	Amp-dependent synthetase and ligase
TOPB45_1303	ENOG4108JIU	phosphoribosylformylglycinamidine synthase ii
TOPB45_1304	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
TOPB45_1305	ENOG4105CTQ	phosphohexokinase
TOPB45_1307	ENOG4107ZTM	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
TOPB45_1309	ENOG41090A1	ferritin
TOPB45_1311	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
TOPB45_1312	ENOG4108A51	
TOPB45_1313	ENOG4107XQ1	cobalamin (vitamin B12) biosynthesis CbiM protein
TOPB45_1318	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
TOPB45_1319	ENOG4105BZU	Histidine kinase
TOPB45_1320	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
TOPB45_1321	ENOG4108VYJ	response regulator receiver protein
TOPB45_1325	ENOG4108VYJ	response regulator receiver protein
TOPB45_1326	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
TOPB45_1327	ENOG4107R21	site-determining protein
TOPB45_1328	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TOPB45_1329	ENOG4105D7B	Flagellar biosynthesis protein flha
TOPB45_1330	ENOG4105D00	flagellar biosynthetic protein flhB
TOPB45_1332	ENOG4105VS8	Flagellar biosynthetic protein fliq
TOPB45_1333	ENOG4105CN7	Flagellar biosynthetic protein FliP
TOPB45_1335	ENOG4105DD5	Flagellar motor switch protein
TOPB45_1336	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
TOPB45_1339	ENOG4108UVJ	appr-1-p processing domain protein
TOPB45_1344	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
TOPB45_1347	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
TOPB45_1348	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
TOPB45_1352	ENOG4105C37	(CBS) domain
TOPB45_1355	ENOG4105C4R	Atp-dependent dna helicase
TOPB45_1357	ENOG4108JA2	transcriptioN-repair coupling factor
TOPB45_1358	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
TOPB45_1359	ENOG4105K46	50S ribosomal protein l27
TOPB45_1360	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
TOPB45_1363	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
TOPB45_1364	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
TOPB45_1365	ENOG4105EEI	dihydropteroate synthase
TOPB45_1366	ENOG4105C8B	TIGR00159 family
TOPB45_1368	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
TOPB45_1371	ENOG4105DR4	Methyltransferase
TOPB45_1376	ENOG4108RWN	rrna methyltransferase
TOPB45_1380	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
TOPB45_1382	ENOG4107RB4	Cytidine monophosphate kinase
TOPB45_1383	ENOG4105M7K	Involved in the transcription termination process (By similarity)
TOPB45_1384	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
TOPB45_1385	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
TOPB45_1386	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
TOPB45_1387	ENOG4108U7W	acetyltransferase
TOPB45_1388	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
TOPB45_1389	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
TOPB45_1391	ENOG4108IUZ	ABC transporter
TOPB45_1393	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
TOPB45_1394	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
TOPB45_1396	ENOG4107QX8	SPFH domain, Band 7 family protein
TOPB45_1398	ENOG4105C7K	acetolactate synthase
TOPB45_1399	ENOG4108ZP8	Acetolactate synthase small subunit
TOPB45_1400	ENOG4108HHA	Transketolase
TOPB45_1401	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
TOPB45_1405	ENOG4105Z0W	Dissimilatory sulfite reductase D
TOPB45_1406	ENOG4105PJW	Sulfite reductase dissimilatory-type beta subunit
TOPB45_1407	ENOG4105CY1	sulfite reductase, dissimilatory-type alpha subunit
TOPB45_1408	ENOG4107QHF	type ii secretion system protein e
TOPB45_1409	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
TOPB45_1410	ENOG4105CY0	Metallo-Beta-Lactamase
TOPB45_1412	ENOG4105VB9	50S ribosomal protein l28
TOPB45_1413	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
TOPB45_1414	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
TOPB45_1416	ENOG41086K9	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
TOPB45_1417	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
TOPB45_1427	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
TOPB45_1428	ENOG4105C4M	(Ubiquinol oxidase) subunit I
TOPB45_1431	ENOG4108T9Q	UPF0278 protein
TOPB45_1433	ENOG4105C8T	Leucyl-tRNA synthetase
TOPB45_1434	ENOG4108HMX	isocitrate dehydrogenase (NADP)
TOPB45_1435	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
TOPB45_1436	ENOG4105F7J	membrane-bound serine protease
TOPB45_1438	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
TOPB45_1440	ENOG4105DFM	M18 family aminopeptidase
TOPB45_1442	ENOG41082E4	Binds directly to 16S ribosomal RNA (By similarity)
TOPB45_1443	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
TOPB45_1444	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
TOPB45_1446	ENOG4105DCU	2-hydroxyglutaryl-CoA dehydratase
TOPB45_1447	ENOG4105CIZ	coA-substrate-specific enzyme activase
TOPB45_1448	ENOG4105DUM	transcriptional regulator, lysR family
TOPB45_1450	ENOG4107WHI	formate dehydrogenase, beta subunit
TOPB45_1452	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
TOPB45_1455	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
TOPB45_1457	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
TOPB45_1459	ENOG4107QQM	Cysteine-rich domain
TOPB45_1461	ENOG4105EE5	Membrane protein terC
TOPB45_1462	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
TOPB45_1463	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
TOPB45_1464	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
TOPB45_1467	ENOG4108NVR	Methyl-accepting chemotaxis
TOPB45_1468	ENOG4105YVF	chew protein
TOPB45_1469	ENOG4105CBS	Chea signal transduction histidine kinase
TOPB45_1470	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
TOPB45_1471	ENOG4108194	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
TOPB45_1472	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
TOPB45_1476	ENOG4105CQC	Prephenate dehydratase
TOPB45_1478	ENOG4105CHV	Transcription elongation factor NusA
TOPB45_1479	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
TOPB45_1481	ENOG4105CSH	Transporter
TOPB45_1482	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
TOPB45_1484	ENOG4105DZ0	fad dependent oxidoreductase
TOPB45_1485	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
TOPB45_1486	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
TOPB45_1487	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
TOPB45_1489	ENOG4105CJ5	hydrogenase 2 b cytochrome subunit
TOPB45_1490	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
TOPB45_1492	ENOG4105F1C	cytochrome c
TOPB45_1496	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
TOPB45_1497	ENOG4105DCG	PHP domain protein
TOPB45_1498	ENOG4105DZ1	carboxypeptidase
TOPB45_1499	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
TOPB45_1500	ENOG4105C5X	domain protein
TOPB45_1501	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
TOPB45_1502	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
TOPB45_1503	ENOG4105E2X	shikimate dehydrogenase
TOPB45_1505	ENOG4105DC1	bifunctional purine biosynthesis protein purh
TOPB45_1506	ENOG4105EZY	Pyrroloquinoline quinone biosynthesis protein E
TOPB45_1508	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
TOPB45_1509	ENOG4105C25	Primosomal protein n'
TOPB45_1512	ENOG4105CZX	twitching motility protein
TOPB45_1513	ENOG4105CZX	twitching motility protein
TOPB45_1516	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
TOPB45_1517	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
TOPB45_1518	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
TOPB45_1519	ENOG4105FF6	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
TOPB45_1521	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
TOPB45_1524	ENOG4105KQC	Competence protein
TOPB45_1525	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
TOPB45_1528	ENOG4105C75	arginyL-tRNA synthetase
TOPB45_1530	ENOG4105C34	Pseudouridine synthase
TOPB45_1532	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
TOPB45_1533	ENOG4105CFG	Acts as a chaperone (By similarity)
TOPB45_1534	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TOPB45_1536	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
TOPB45_1538	ENOG4107RD7	Flagellar Motor Protein, MotA
TOPB45_1540	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
TOPB45_1543	ENOG4105DFA	alanine racemase domain protein
TOPB45_1545	ENOG41082MC	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
TOPB45_1546	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
TOPB45_1547	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
TOPB45_1548	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
TOPB45_1549	ENOG4105E3N	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
TOPB45_1552	ENOG4105CNI	cell division protein FtsW
TOPB45_1553	ENOG4105CJN	penicillin-binding protein
TOPB45_1555	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
TOPB45_1556	ENOG4105D98	threonine synthase
TOPB45_1558	ENOG4108RQ5	Beta-lactamase domain-containing protein
TOPB45_1561	ENOG4105CHM	Aminotransferase
TOPB45_1562	ENOG4107SDT	Homocitrate synthase
TOPB45_1568	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
TOPB45_1569	ENOG4107W7W	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
TOPB45_1571	ENOG4105CGA	flagellar basal-body rod protein FlgG
TOPB45_1572	ENOG4105CGA	flagellar basal-body rod protein FlgG
TOPB45_1573	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TOPB45_1574	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
TOPB45_1576	ENOG4105CRK	lysyL-tRNA synthetase
TOPB45_1580	ENOG4105VEQ	Cold shock protein
TOPB45_1582	ENOG4108MYP	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
TOPB45_1583	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
TOPB45_1584	ENOG4108QHG	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
TOPB45_1586	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
TOPB45_1589	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
TOPB45_1591	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
TOPB45_1594	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
TOPB45_1595	ENOG4105D48	metallophosphoesterase
TOPB45_1596	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
TOPB45_1597	ENOG4105CHR	reductase
TOPB45_1598	ENOG4105EJ5	oxidoreductase gamma subunit
TOPB45_1600	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
TOPB45_1601	ENOG4105DDK	oxidoreductase, beta subunit
TOPB45_1602	ENOG4105E8R	UPF0173 metal-dependent hydrolase
TOPB45_1604	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
TOPB45_1606	ENOG4105G5W	regulator Fur family
TOPB45_1607	ENOG4105EGD	dinuclear metal center protein, YbgI family
TOPB45_1609	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
TOPB45_1612	ENOG4108IYU	L-aspartate oxidase
TOPB45_1613	ENOG4105E3H	phosphoglycerate mutase
TOPB45_1614	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
TOPB45_1615	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
TOPB45_1616	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
TOPB45_1617	ENOG4105C3M	thioredoxin reductase
TOPB45_1620	ENOG4105CH7	arginosuccinase
TOPB45_1625	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
TOPB45_1626	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
TOPB45_1627	ENOG4105KK6	nuclease
TOPB45_1629	ENOG4105MQ3	flagellar protein FliS
TOPB45_1632	ENOG4105DBV	ornithine carbamoyltransferase
TOPB45_1634	ENOG4105C3U	ABC transporter
TOPB45_1635	ENOG4108JQ7	(ABC) transporter