locus-tag	class	description
TOPB45_0002	COG0277	FAD linked oxidase domain protein
TOPB45_0003	COG0037	tRNA processing
TOPB45_0004	COG0741	lytic transglycosylase activity
TOPB45_0005	COG0668	transmembrane transport
TOPB45_0012	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TOPB45_0012	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TOPB45_0014	COG0698	ribose 5-phosphate isomerase
TOPB45_0015	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TOPB45_0016	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TOPB45_0019	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TOPB45_0020	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
TOPB45_0022	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TOPB45_0023	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TOPB45_0024	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TOPB45_0025	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TOPB45_0026	COG0138	bifunctional purine biosynthesis protein purh
TOPB45_0027	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TOPB45_0030	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TOPB45_0031	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TOPB45_0034	COG1127	ABC transporter
TOPB45_0036	COG0129	dihydroxy-acid dehydratase activity
TOPB45_0037	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
TOPB45_0038	COG1758	RNA polymerase activity
TOPB45_0039	COG0484	heat shock protein binding
TOPB45_0040	COG0315	cyclic pyranopterin monophosphate synthase activity
TOPB45_0042	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TOPB45_0043	COG0517	IMP dehydrogenase activity
TOPB45_0043	COG0516	GMP reductase activity
TOPB45_0046	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TOPB45_0047	COG0750	zinc metalloprotease
TOPB45_0048	COG1214	PFAM Peptidase M22, glycoprotease
TOPB45_0049	COG0601	transmembrane transport
TOPB45_0050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TOPB45_0056	COG2204	response regulator
TOPB45_0057	COG1815	bacterial-type flagellum-dependent cell motility
TOPB45_0058	COG1558	bacterial-type flagellum-dependent cell motility
TOPB45_0059	COG1677	Flagellar hook-basal body complex protein FliE
TOPB45_0060	COG1766	The M ring may be actively involved in energy transduction
TOPB45_0061	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TOPB45_0063	COG1157	protein secretion by the type III secretion system
TOPB45_0066	COG0805	protein transport
TOPB45_0067	COG0047	phosphoribosylformylglycinamidine synthase activity
TOPB45_0071	COG0628	permease
TOPB45_0074	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TOPB45_0075	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TOPB45_0076	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TOPB45_0077	COG0193	aminoacyl-tRNA hydrolase activity
TOPB45_0079	COG0519	Catalyzes the synthesis of GMP from XMP
TOPB45_0083	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TOPB45_0084	COG0416	fatty acid biosynthetic process
TOPB45_0085	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TOPB45_0088	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TOPB45_0090	COG1007	ATP synthesis coupled electron transport
TOPB45_0093	COG0713	ATP synthesis coupled electron transport
TOPB45_0094	COG0839	Belongs to the complex I subunit 6 family
TOPB45_0095	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TOPB45_0096	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TOPB45_0097	COG0649	NAD binding
TOPB45_0098	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TOPB45_0099	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TOPB45_0100	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TOPB45_0101	COG0437	4 iron, 4 sulfur cluster binding
TOPB45_0103	COG1832	CoA-binding protein
TOPB45_0104	COG0149	triose-phosphate isomerase activity
TOPB45_0105	COG0126	phosphoglycerate kinase activity
TOPB45_0106	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TOPB45_0109	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TOPB45_0109	COG0574	Belongs to the PEP-utilizing enzyme family
TOPB45_0110	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TOPB45_0112	COG0746	molybdenum cofactor guanylyltransferase activity
TOPB45_0117	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TOPB45_0119	COG3118	belongs to the thioredoxin family
TOPB45_0122	COG0653	protein targeting
TOPB45_0123	COG0585	pseudouridine synthase activity
TOPB45_0124	COG0859	PFAM glycosyl transferase family 9
TOPB45_0126	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TOPB45_0127	COG0312	modulator of DNA gyrase
TOPB45_0128	COG0148	phosphopyruvate hydratase activity
TOPB45_0129	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TOPB45_0129	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TOPB45_0130	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TOPB45_0132	COG0420	3'-5' exonuclease activity
TOPB45_0133	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TOPB45_0134	COG0489	protein tyrosine kinase activity
TOPB45_0137	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TOPB45_0138	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TOPB45_0139	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TOPB45_0144	COG1515	deoxyribonuclease V activity
TOPB45_0145	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TOPB45_0148	COG0732	type I restriction modification DNA specificity domain
TOPB45_0151	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TOPB45_0152	COG1970	mechanosensitive ion channel activity
TOPB45_0154	COG0426	domain, Protein
TOPB45_0154	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TOPB45_0157	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TOPB45_0157	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TOPB45_0158	COG0237	dephospho-CoA kinase activity
TOPB45_0159	COG0564	pseudouridine synthase activity
TOPB45_0161	COG0739	heme binding
TOPB45_0162	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TOPB45_0163	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TOPB45_0164	COG0085	RNA polymerase activity
TOPB45_0165	COG0222	ribosome binding
TOPB45_0166	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TOPB45_0167	COG0081	regulation of translation
TOPB45_0168	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TOPB45_0170	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TOPB45_0171	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TOPB45_0172	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TOPB45_0174	COG1233	COG1233 Phytoene dehydrogenase and related
TOPB45_0175	COG1053	succinate dehydrogenase
TOPB45_0179	COG2046	Belongs to the sulfate adenylyltransferase family
TOPB45_0180	COG0142	geranyltranstransferase activity
TOPB45_0182	COG1074	ATP-dependent DNA helicase activity
TOPB45_0183	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TOPB45_0186	COG0589	response to stress
TOPB45_0187	COG0305	Participates in initiation and elongation during chromosome replication
TOPB45_0188	COG0359	binds to the 23S rRNA
TOPB45_0189	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TOPB45_0190	COG0360	Binds together with S18 to 16S ribosomal RNA
TOPB45_0191	COG0494	nUDIX hydrolase
TOPB45_0192	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TOPB45_0193	COG1388	LysM domain
TOPB45_0193	COG0791	NLP P60 protein
TOPB45_0194	COG3706	GGDEF domain
TOPB45_0196	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TOPB45_0196	COG0517	IMP dehydrogenase activity
TOPB45_0197	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TOPB45_0201	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TOPB45_0202	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TOPB45_0203	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TOPB45_0204	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TOPB45_0205	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TOPB45_0207	COG0432	Pfam Uncharacterised protein family UPF0047
TOPB45_0209	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TOPB45_0210	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TOPB45_0218	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TOPB45_0219	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TOPB45_0222	COG1192	Involved in chromosome partitioning
TOPB45_0225	COG1309	transcriptional regulator
TOPB45_0228	COG1538	Outer membrane efflux protein
TOPB45_0230	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TOPB45_0232	COG0742	ribosomal rna small subunit methyltransferase
TOPB45_0236	COG1104	cysteine desulfurase activity
TOPB45_0237	COG1110	DNA topoisomerase II activity
TOPB45_0238	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TOPB45_0239	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TOPB45_0240	COG5002	protein histidine kinase activity
TOPB45_0240	COG5001	Diguanylate cyclase
TOPB45_0243	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TOPB45_0245	COG0629	single-stranded DNA binding
TOPB45_0246	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TOPB45_0247	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TOPB45_0249	COG1032	radical SAM domain protein
TOPB45_0252	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TOPB45_0253	COG0254	rRNA binding
TOPB45_0254	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TOPB45_0255	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TOPB45_0259	COG1381	Involved in DNA repair and RecF pathway recombination
TOPB45_0260	COG1611	Belongs to the LOG family
TOPB45_0261	COG0540	Belongs to the ATCase OTCase family
TOPB45_0263	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
TOPB45_0264	COG1376	ErfK ybiS ycfS ynhG family protein
TOPB45_0265	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TOPB45_0269	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TOPB45_0270	COG0402	S-adenosylhomocysteine deaminase activity
TOPB45_0272	COG2226	methyltransferase
TOPB45_0273	COG0745	RESPONSE REGULATOR receiver
TOPB45_0273	COG3706	GGDEF domain
TOPB45_0275	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TOPB45_0276	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TOPB45_0279	COG0058	SHG alpha-glucan phosphorylase activity
TOPB45_0283	COG0012	GTP binding
TOPB45_0285	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TOPB45_0286	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TOPB45_0288	COG2814	Major facilitator Superfamily
TOPB45_0289	COG1566	PFAM secretion protein HlyD family protein
TOPB45_0293	COG2067	long-chain fatty acid transport protein
TOPB45_0294	COG0166	Belongs to the GPI family
TOPB45_0295	COG0113	porphobilinogen synthase activity
TOPB45_0296	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TOPB45_0297	COG0571	ribonuclease III activity
TOPB45_0299	COG2747	anti-sigma28 factor FlgM
TOPB45_0300	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TOPB45_0300	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TOPB45_0301	COG1040	competence protein
TOPB45_0302	COG2195	Cleaves the N-terminal amino acid of tripeptides
TOPB45_0303	COG1254	Belongs to the acylphosphatase family
TOPB45_0307	COG0003	Pfam Anion-transporting ATPase
TOPB45_0308	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TOPB45_0309	COG0556	nucleotide-excision repair
TOPB45_0312	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TOPB45_0313	COG0352	thiamine-phosphate diphosphorylase activity
TOPB45_0319	COG0745	RESPONSE REGULATOR receiver
TOPB45_0319	COG3706	GGDEF domain
TOPB45_0336	COG2244	polysaccharide biosynthetic process
TOPB45_0350	COG0438	transferase activity, transferring glycosyl groups
TOPB45_0352	COG1598	PFAM Uncharacterised protein family UPF0150
TOPB45_0362	COG0492	ferredoxin-NADP+ reductase activity
TOPB45_0367	COG1077	Cell shape determining protein MreB Mrl
TOPB45_0369	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TOPB45_0369	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TOPB45_0370	COG0436	Aminotransferase
TOPB45_0372	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TOPB45_0374	COG0512	Glutamine amidotransferase of anthranilate synthase
TOPB45_0374	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TOPB45_0376	COG0124	histidyl-tRNA synthetase
TOPB45_0377	COG0446	pyridine nucleotide-disulphide oxidoreductase
TOPB45_0378	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TOPB45_0379	COG0006	proline dipeptidase activity
TOPB45_0380	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
TOPB45_0383	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
TOPB45_0387	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TOPB45_0388	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TOPB45_0389	COG4206	TonB-dependent receptor
TOPB45_0392	COG0492	ferredoxin-NADP+ reductase activity
TOPB45_0396	COG0646	methionine synthase
TOPB45_0396	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TOPB45_0399	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TOPB45_0400	COG2759	Belongs to the formate--tetrahydrofolate ligase family
TOPB45_0401	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TOPB45_0402	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TOPB45_0402	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TOPB45_0403	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TOPB45_0406	COG0589	response to stress
TOPB45_0407	COG1335	isochorismatase
TOPB45_0408	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TOPB45_0409	COG0612	Peptidase, M16
TOPB45_0410	COG0802	atpase or kinase
TOPB45_0411	COG0837	glucose binding
TOPB45_0413	COG2885	chlorophyll binding
TOPB45_0416	COG0552	protein localization to endoplasmic reticulum
TOPB45_0418	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
TOPB45_0419	COG1408	metallophosphoesterase
TOPB45_0420	COG0179	Fumarylacetoacetate (FAA) hydrolase
TOPB45_0421	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TOPB45_0422	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TOPB45_0424	COG3706	GGDEF domain
TOPB45_0425	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TOPB45_0426	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TOPB45_0428	COG0860	N-Acetylmuramoyl-L-alanine amidase
TOPB45_0429	COG3876	Protein conserved in bacteria
TOPB45_0431	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TOPB45_0432	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TOPB45_0433	COG0587	DNA-directed DNA polymerase activity
TOPB45_0435	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
TOPB45_0436	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TOPB45_0437	COG0123	including yeast histone deacetylase and acetoin utilization protein
TOPB45_0438	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TOPB45_0439	COG1131	(ABC) transporter
TOPB45_0440	COG0842	Transport permease protein
TOPB45_0440	COG1129	ABC transporter
TOPB45_0441	COG0842	Transport permease protein
TOPB45_0445	COG4783	chaperone-mediated protein folding
TOPB45_0449	COG0133	tryptophan synthase activity
TOPB45_0450	COG0159	tryptophan synthase activity
TOPB45_0451	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TOPB45_0452	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TOPB45_0453	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TOPB45_0454	COG1979	alcohol dehydrogenase
TOPB45_0458	COG0745	RESPONSE REGULATOR receiver
TOPB45_0459	COG5002	protein histidine kinase activity
TOPB45_0460	COG3300	MHYT domain
TOPB45_0460	COG5001	Diguanylate cyclase
TOPB45_0463	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
TOPB45_0465	COG0375	protein maturation
TOPB45_0466	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
TOPB45_0467	COG0589	response to stress
TOPB45_0470	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
TOPB45_0470	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
TOPB45_0471	COG3706	GGDEF domain
TOPB45_0472	COG0590	tRNA wobble adenosine to inosine editing
TOPB45_0473	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TOPB45_0474	COG2003	Belongs to the UPF0758 family
TOPB45_0476	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
TOPB45_0477	COG2877	3-deoxy-8-phosphooctulonate synthase activity
TOPB45_0482	COG0438	transferase activity, transferring glycosyl groups
TOPB45_0486	COG0137	argininosuccinate synthase activity
TOPB45_0487	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TOPB45_0488	COG0671	phosphoesterase, PA-phosphatase related
TOPB45_0490	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TOPB45_0494	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TOPB45_0495	COG1324	tolerance protein
TOPB45_0496	COG0303	'Molybdopterin
TOPB45_0498	COG0437	4 iron, 4 sulfur cluster binding
TOPB45_0500	COG1910	domain protein
TOPB45_0501	COG1295	ribonuclease BN
TOPB45_0501	COG1959	2 iron, 2 sulfur cluster binding
TOPB45_0503	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TOPB45_0506	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TOPB45_0510	COG0438	transferase activity, transferring glycosyl groups
TOPB45_0512	COG0438	transferase activity, transferring glycosyl groups
TOPB45_0517	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TOPB45_0518	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TOPB45_0519	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TOPB45_0524	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TOPB45_0525	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TOPB45_0526	COG0573	inorganic phosphate transmembrane transporter activity
TOPB45_0528	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TOPB45_0529	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TOPB45_0530	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TOPB45_0532	COG0196	riboflavin kinase activity
TOPB45_0533	COG0505	Belongs to the CarA family
TOPB45_0536	COG0426	domain, Protein
TOPB45_0538	COG1773	rubredoxin
TOPB45_0539	COG1773	rubredoxin
TOPB45_0540	COG1773	rubredoxin
TOPB45_0541	COG2033	superoxide reductase activity
TOPB45_0544	COG0072	phenylalanine-tRNA ligase activity
TOPB45_0545	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TOPB45_0546	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TOPB45_0547	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TOPB45_0548	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TOPB45_0549	COG2255	four-way junction helicase activity
TOPB45_0550	COG0840	transmembrane signaling receptor activity
TOPB45_0554	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TOPB45_0556	COG0450	alkyl hydroperoxide reductase
TOPB45_0559	COG0312	modulator of DNA gyrase
TOPB45_0560	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TOPB45_0561	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TOPB45_0563	COG0442	prolyl-tRNA aminoacylation
TOPB45_0564	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TOPB45_0567	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
TOPB45_0569	COG2703	oxygen carrier activity
TOPB45_0573	COG2264	protein methyltransferase activity
TOPB45_0576	COG0632	four-way junction helicase activity
TOPB45_0578	COG0217	transcriptional regulatory protein
TOPB45_0580	COG2084	Dehydrogenase
TOPB45_0584	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TOPB45_0585	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TOPB45_0586	COG0134	indole-3-glycerol-phosphate synthase activity
TOPB45_0587	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TOPB45_0588	COG0594	ribonuclease P activity
TOPB45_0589	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TOPB45_0590	COG0706	membrane insertase activity
TOPB45_0592	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TOPB45_0595	COG0351	phosphomethylpyrimidine kinase
TOPB45_0596	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TOPB45_0597	COG0154	amidase activity
TOPB45_0598	COG1475	DNA binding
TOPB45_0599	COG0438	transferase activity, transferring glycosyl groups
TOPB45_0602	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TOPB45_0605	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TOPB45_0606	COG1058	Belongs to the CinA family
TOPB45_0606	COG1546	Belongs to the CinA family
TOPB45_0607	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
TOPB45_0609	COG1090	epimerase
TOPB45_0610	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TOPB45_0611	COG0589	response to stress
TOPB45_0613	COG0463	Glycosyl transferase, family 2
TOPB45_0613	COG1216	Glycosyl transferase, family 2
TOPB45_0614	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TOPB45_0616	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TOPB45_0617	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TOPB45_0619	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TOPB45_0620	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TOPB45_0621	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TOPB45_0622	COG0307	riboflavin synthase, alpha
TOPB45_0624	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TOPB45_0625	COG0306	phosphate transporter
TOPB45_0628	COG0483	inositol monophosphate 1-phosphatase activity
TOPB45_0629	COG3706	GGDEF domain
TOPB45_0629	COG0745	RESPONSE REGULATOR receiver
TOPB45_0630	COG0557	exoribonuclease II activity
TOPB45_0633	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TOPB45_0633	COG0045	succinate-CoA ligase (ADP-forming) activity
TOPB45_0633	COG1042	CoA-binding domain protein
TOPB45_0635	COG0402	S-adenosylhomocysteine deaminase activity
TOPB45_0636	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TOPB45_0637	COG1979	alcohol dehydrogenase
TOPB45_0638	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TOPB45_0639	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TOPB45_0642	COG1309	transcriptional regulator
TOPB45_0645	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TOPB45_0647	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TOPB45_0649	COG1620	l-lactate permease
TOPB45_0654	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TOPB45_0655	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TOPB45_0656	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TOPB45_0657	COG0477	Major facilitator Superfamily
TOPB45_0660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TOPB45_0662	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TOPB45_0663	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TOPB45_0665	COG2204	response regulator
TOPB45_0666	COG5002	protein histidine kinase activity
TOPB45_0667	COG0671	phosphoesterase, PA-phosphatase related
TOPB45_0669	COG1490	D-aminoacyl-tRNA deacylase activity
TOPB45_0674	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TOPB45_0675	COG0509	glycine decarboxylation via glycine cleavage system
TOPB45_0676	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TOPB45_0677	COG1980	fructose-bisphosphate aldolase activity
TOPB45_0684	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
TOPB45_0685	COG1674	ftsk spoiiie
TOPB45_0688	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TOPB45_0689	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TOPB45_0690	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TOPB45_0692	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TOPB45_0693	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TOPB45_0693	COG0731	radical SAM domain protein
TOPB45_0694	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TOPB45_0695	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TOPB45_0697	COG0019	diaminopimelate decarboxylase activity
TOPB45_0698	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TOPB45_0701	COG0708	Exodeoxyribonuclease III
TOPB45_0704	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TOPB45_0705	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TOPB45_0707	COG1837	Belongs to the UPF0109 family
TOPB45_0708	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TOPB45_0709	COG4752	Belongs to the RNA methyltransferase TrmD family
TOPB45_0709	COG0336	Belongs to the RNA methyltransferase TrmD family
TOPB45_0710	COG2608	mercury ion transmembrane transporter activity
TOPB45_0711	COG2217	Heavy metal translocating P-type atpase
TOPB45_0713	COG0511	ligase activity, forming carbon-carbon bonds
TOPB45_0715	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TOPB45_0716	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TOPB45_0717	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TOPB45_0718	COG0101	tRNA pseudouridine synthase activity
TOPB45_0719	COG0131	Imidazoleglycerol-phosphate dehydratase
TOPB45_0721	COG0215	cysteine-tRNA ligase activity
TOPB45_0722	COG2894	cell division
TOPB45_0723	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TOPB45_0724	COG0527	aspartate kinase activity
TOPB45_0729	COG0531	amino acid
TOPB45_0734	COG1131	(ABC) transporter
TOPB45_0736	COG2078	PFAM AMMECR1 domain protein
TOPB45_0738	COG0778	Nitroreductase
TOPB45_0740	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TOPB45_0741	COG0484	heat shock protein binding
TOPB45_0742	COG2131	deaminase
TOPB45_0743	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TOPB45_0744	COG0463	Glycosyl transferase, family 2
TOPB45_0748	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TOPB45_0749	COG0049	tRNA binding
TOPB45_0750	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TOPB45_0751	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TOPB45_0752	COG0051	transcription antitermination factor activity, RNA binding
TOPB45_0753	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TOPB45_0754	COG0088	Forms part of the polypeptide exit tunnel
TOPB45_0756	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TOPB45_0757	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TOPB45_0758	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TOPB45_0759	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TOPB45_0760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TOPB45_0761	COG0255	Belongs to the universal ribosomal protein uL29 family
TOPB45_0762	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TOPB45_0763	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TOPB45_0764	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TOPB45_0765	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TOPB45_0766	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TOPB45_0767	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TOPB45_0768	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TOPB45_0769	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TOPB45_0770	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TOPB45_0771	COG1841	ribosomal large subunit assembly
TOPB45_0772	COG0200	Binds to the 23S rRNA
TOPB45_0773	COG0201	protein transport
TOPB45_0774	COG0563	adenylate kinase activity
TOPB45_0776	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TOPB45_0778	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TOPB45_0779	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TOPB45_0780	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TOPB45_0781	COG0202	RNA polymerase activity
TOPB45_0782	COG0203	ribosomal protein L17
TOPB45_0783	COG0617	tRNA 3'-terminal CCA addition
TOPB45_0784	COG0544	peptidyl-prolyl cis-trans isomerase activity
TOPB45_0785	COG0740	serine-type endopeptidase activity
TOPB45_0786	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TOPB45_0787	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TOPB45_0788	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TOPB45_0790	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
TOPB45_0792	COG5000	phosphorelay sensor kinase activity
TOPB45_0793	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TOPB45_0793	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TOPB45_0794	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TOPB45_0796	COG0358	DNA primase activity
TOPB45_0799	COG0730	response to heat
TOPB45_0800	COG0501	Belongs to the peptidase M48B family
TOPB45_0817	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TOPB45_0821	COG1434	Gram-negative-bacterium-type cell wall biogenesis
TOPB45_0822	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
TOPB45_0824	COG2204	response regulator
TOPB45_0827	COG0010	Belongs to the arginase family
TOPB45_0833	COG4974	Belongs to the 'phage' integrase family
TOPB45_0834	COG0617	tRNA 3'-terminal CCA addition
TOPB45_0835	COG0539	negative regulation of cytoplasmic translation
TOPB45_0836	COG0616	signal peptide processing
TOPB45_0837	COG0776	regulation of translation
TOPB45_0838	COG0516	GMP reductase activity
TOPB45_0838	COG0517	IMP dehydrogenase activity
TOPB45_0839	COG1459	type II secretion system
TOPB45_0841	COG1968	undecaprenyl-diphosphatase activity
TOPB45_0843	COG2890	protein-(glutamine-N5) methyltransferase activity
TOPB45_0844	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TOPB45_0845	COG0470	DNA polymerase III
TOPB45_0850	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TOPB45_0851	COG0811	peptide transport
TOPB45_0852	COG0848	biopolymer transport protein
TOPB45_0857	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TOPB45_0859	COG1793	dna ligase
TOPB45_0869	COG0714	Associated with various cellular activities
TOPB45_0872	COG0750	zinc metalloprotease
TOPB45_0875	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TOPB45_0879	COG0356	it plays a direct role in the translocation of protons across the membrane
TOPB45_0880	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TOPB45_0882	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TOPB45_0882	COG1213	nucleotidyl transferase
TOPB45_0885	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
TOPB45_0886	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
TOPB45_0888	COG0640	Transcriptional regulator
TOPB45_0893	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
TOPB45_0894	COG3852	Histidine kinase
TOPB45_0896	COG0437	4 iron, 4 sulfur cluster binding
TOPB45_0902	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TOPB45_0903	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TOPB45_0906	COG0473	3-isopropylmalate dehydrogenase activity
TOPB45_0907	COG0322	excinuclease ABC activity
TOPB45_0908	COG2197	response regulator
TOPB45_0914	COG1462	curli production assembly transport component CsgG
TOPB45_0915	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
TOPB45_0917	COG1459	type II secretion system
TOPB45_0919	COG3267	Type II secretory pathway component ExeA
TOPB45_0919	COG3409	Peptidoglycan-binding domain 1 protein
TOPB45_0927	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TOPB45_0930	COG0497	DNA recombination
TOPB45_0931	COG3842	ATPase activity
TOPB45_0935	COG2001	Belongs to the MraZ family
TOPB45_0936	COG0275	rRNA processing
TOPB45_0939	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TOPB45_0940	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TOPB45_0944	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TOPB45_0945	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TOPB45_0951	COG0135	phosphoribosylanthranilate isomerase activity
TOPB45_0955	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TOPB45_0956	COG0167	dihydroorotate dehydrogenase activity
TOPB45_0957	COG0543	2 iron, 2 sulfur cluster binding
TOPB45_0960	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TOPB45_0960	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TOPB45_0962	COG0463	Glycosyl transferase, family 2
TOPB45_0969	COG5002	protein histidine kinase activity
TOPB45_0970	COG2204	response regulator
TOPB45_0973	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TOPB45_0978	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TOPB45_0978	COG1648	precorrin-2 dehydrogenase activity
TOPB45_0979	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
TOPB45_0980	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TOPB45_0981	COG0335	large ribosomal subunit rRNA binding
TOPB45_0982	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TOPB45_0983	COG0792	nuclease activity
TOPB45_0986	COG0460	homoserine dehydrogenase
TOPB45_0992	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TOPB45_0993	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TOPB45_0996	COG0758	DNA mediated transformation
TOPB45_0997	COG2814	Major facilitator Superfamily
TOPB45_0998	COG0151	Belongs to the GarS family
TOPB45_0999	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TOPB45_1000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TOPB45_1000	COG0425	Belongs to the sulfur carrier protein TusA family
TOPB45_1002	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TOPB45_1006	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TOPB45_1007	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TOPB45_1008	COG0542	response to heat
TOPB45_1010	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TOPB45_1011	COG0105	UTP biosynthetic process
TOPB45_1013	COG1994	Peptidase M50
TOPB45_1014	COG0793	Belongs to the peptidase S41A family
TOPB45_1015	COG0052	Belongs to the universal ribosomal protein uS2 family
TOPB45_1016	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TOPB45_1017	COG0528	UMP kinase activity
TOPB45_1018	COG0233	cytoplasmic translational termination
TOPB45_1020	COG4589	Belongs to the CDS family
TOPB45_1022	COG1181	Belongs to the D-alanine--D-alanine ligase family
TOPB45_1024	COG2823	Periplasmic or secreted lipoprotein
TOPB45_1025	COG1242	4 iron, 4 sulfur cluster binding
TOPB45_1029	COG0445	tRNA wobble uridine modification
TOPB45_1033	COG0210	DNA helicase
TOPB45_1036	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TOPB45_1037	COG0525	valine-tRNA ligase activity
TOPB45_1039	COG1196	nuclear chromosome segregation
TOPB45_1045	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TOPB45_1048	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TOPB45_1062	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TOPB45_1068	COG0577	efflux transmembrane transporter activity
TOPB45_1068	COG1136	(ABC) transporter
TOPB45_1069	COG1136	(ABC) transporter
TOPB45_1069	COG0577	efflux transmembrane transporter activity
TOPB45_1070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TOPB45_1072	COG0531	amino acid
TOPB45_1073	COG2095	MarC family integral membrane protein
TOPB45_1075	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TOPB45_1077	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TOPB45_1079	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TOPB45_1080	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TOPB45_1081	COG1355	regulation of microtubule-based process
TOPB45_1082	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TOPB45_1083	COG5001	Diguanylate cyclase
TOPB45_1083	COG5002	protein histidine kinase activity
TOPB45_1101	COG4637	Psort location Cytoplasmic, score
TOPB45_1109	COG1353	crispr-associated protein
TOPB45_1111	COG1337	RAMP superfamily
TOPB45_1118	COG1518	maintenance of DNA repeat elements
TOPB45_1122	COG2149	membrane
TOPB45_1123	COG1187	pseudouridine synthase activity
TOPB45_1124	COG3158	transport of potassium into the cell
TOPB45_1125	COG3706	GGDEF domain
TOPB45_1125	COG0745	RESPONSE REGULATOR receiver
TOPB45_1131	COG0180	Tryptophanyl-tRNA synthetase
TOPB45_1132	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TOPB45_1133	COG1333	cytochrome c biogenesis protein
TOPB45_1137	COG0481	GTPase activity
TOPB45_1141	COG0037	tRNA processing
TOPB45_1143	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TOPB45_1145	COG1187	pseudouridine synthase activity
TOPB45_1146	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TOPB45_1147	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TOPB45_1147	COG1519	Transferase
TOPB45_1149	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TOPB45_1152	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TOPB45_1154	COG0557	exoribonuclease II activity
TOPB45_1156	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TOPB45_1157	COG0719	Fe-S assembly protein
TOPB45_1161	COG1185	polyribonucleotide nucleotidyltransferase activity
TOPB45_1163	COG1530	ribonuclease E activity
TOPB45_1164	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
TOPB45_1165	COG0859	PFAM glycosyl transferase family 9
TOPB45_1166	COG1132	(ABC) transporter
TOPB45_1167	COG0501	Belongs to the peptidase M48B family
TOPB45_1169	COG0688	phosphatidylethanolamine metabolic process
TOPB45_1170	COG1183	phosphatidylcholine synthase activity
TOPB45_1171	COG2052	Domain of unknown function (DUF370)
TOPB45_1172	COG0194	GDP metabolic process
TOPB45_1173	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TOPB45_1180	COG2199	diguanylate cyclase activity
TOPB45_1180	COG2203	Gaf domain
TOPB45_1182	COG1918	ferrous iron import across plasma membrane
TOPB45_1183	COG1918	ferrous iron import across plasma membrane
TOPB45_1183	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TOPB45_1185	COG0537	adenosine 5'-monophosphoramidase activity
TOPB45_1186	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TOPB45_1186	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TOPB45_1187	COG1774	PSP1 C-terminal conserved region
TOPB45_1188	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TOPB45_1190	COG2835	tetraacyldisaccharide 4'-kinase activity
TOPB45_1192	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TOPB45_1195	COG3300	MHYT domain
TOPB45_1195	COG5001	Diguanylate cyclase
TOPB45_1196	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TOPB45_1197	COG0284	orotidine-5'-phosphate decarboxylase activity
TOPB45_1203	COG0437	4 iron, 4 sulfur cluster binding
TOPB45_1205	COG1797	cobyrinic acid a,c-diamide synthase activity
TOPB45_1213	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TOPB45_1214	COG1862	Preprotein translocase
TOPB45_1215	COG0343	queuine tRNA-ribosyltransferase activity
TOPB45_1216	COG0436	Aminotransferase
TOPB45_1219	COG1846	Transcriptional regulator
TOPB45_1219	COG0456	acetyltransferase
TOPB45_1226	COG1518	maintenance of DNA repeat elements
TOPB45_1227	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TOPB45_1240	COG0425	Belongs to the sulfur carrier protein TusA family
TOPB45_1242	COG0589	response to stress
TOPB45_1251	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
TOPB45_1252	COG0428	transporter
TOPB45_1255	COG0070	glutamate synthase
TOPB45_1255	COG0069	glutamate synthase activity
TOPB45_1255	COG0067	glutamate synthase
TOPB45_1256	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TOPB45_1257	COG0174	glutamine synthetase
TOPB45_1260	COG0347	Belongs to the P(II) protein family
TOPB45_1262	COG2067	long-chain fatty acid transport protein
TOPB45_1263	COG0318	PFAM AMP-dependent synthetase and ligase
TOPB45_1263	COG0204	Acyl-transferase
TOPB45_1264	COG1141	Ferredoxin
TOPB45_1266	COG0489	protein tyrosine kinase activity
TOPB45_1267	COG1702	phosphate starvation-inducible protein PhoH
TOPB45_1269	COG1872	DUF167
TOPB45_1270	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TOPB45_1270	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TOPB45_1271	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TOPB45_1272	COG0439	Biotin carboxylase
TOPB45_1273	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TOPB45_1275	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
TOPB45_1275	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
TOPB45_1276	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TOPB45_1278	COG2884	Cell division ATP-binding protein ftsE
TOPB45_1282	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TOPB45_1283	COG0752	glycyl-tRNA synthetase alpha subunit
TOPB45_1284	COG0751	glycine-tRNA ligase activity
TOPB45_1286	COG1067	ATP-dependent peptidase activity
TOPB45_1287	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TOPB45_1288	COG0066	3-isopropylmalate dehydratase activity
TOPB45_1289	COG3956	TIGRFAM MazG family protein
TOPB45_1290	COG1121	(ABC) transporter
TOPB45_1291	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TOPB45_1292	COG0084	hydrolase, TatD family'
TOPB45_1293	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TOPB45_1295	COG1573	uracil-dna glycosylase
TOPB45_1296	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TOPB45_1297	COG2086	electron transfer activity
TOPB45_1298	COG1960	acyl-CoA dehydrogenase activity
TOPB45_1299	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TOPB45_1300	COG0318	PFAM AMP-dependent synthetase and ligase
TOPB45_1303	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TOPB45_1307	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TOPB45_1309	COG1528	Iron-storage protein
TOPB45_1311	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TOPB45_1312	COG0310	cobalt ion transport
TOPB45_1313	COG0310	cobalt ion transport
TOPB45_1318	COG0484	heat shock protein binding
TOPB45_1320	COG2201	protein-glutamate methylesterase activity
TOPB45_1326	COG1191	sigma factor activity
TOPB45_1327	COG0455	bacterial-type flagellum organization
TOPB45_1328	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TOPB45_1329	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TOPB45_1330	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TOPB45_1332	COG1987	bacterial-type flagellum assembly
TOPB45_1333	COG1338	Plays a role in the flagellum-specific transport system
TOPB45_1339	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TOPB45_1344	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TOPB45_1347	COG0602	queuosine metabolic process
TOPB45_1348	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TOPB45_1351	COG1253	flavin adenine dinucleotide binding
TOPB45_1352	COG1253	flavin adenine dinucleotide binding
TOPB45_1355	COG0210	DNA helicase
TOPB45_1359	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TOPB45_1360	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TOPB45_1364	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TOPB45_1365	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TOPB45_1366	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TOPB45_1368	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TOPB45_1376	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TOPB45_1380	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TOPB45_1382	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TOPB45_1383	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TOPB45_1384	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TOPB45_1385	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TOPB45_1385	COG0574	Belongs to the PEP-utilizing enzyme family
TOPB45_1386	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TOPB45_1387	COG0456	acetyltransferase
TOPB45_1388	COG1660	Displays ATPase and GTPase activities
TOPB45_1391	COG1137	ATPase activity
TOPB45_1393	COG0459	protein refolding
TOPB45_1394	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TOPB45_1396	COG0330	HflC and HflK could
TOPB45_1398	COG0028	Belongs to the TPP enzyme family
TOPB45_1399	COG0440	acetolactate synthase activity
TOPB45_1400	COG3959	Transketolase, thiamine diphosphate binding domain
TOPB45_1401	COG0805	protein transport
TOPB45_1402	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TOPB45_1403	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TOPB45_1406	COG2221	Nitrite and sulphite reductase 4Fe-4S
TOPB45_1407	COG2221	Nitrite and sulphite reductase 4Fe-4S
TOPB45_1409	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TOPB45_1410	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TOPB45_1412	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TOPB45_1414	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TOPB45_1416	COG1722	exodeoxyribonuclease VII activity
TOPB45_1417	COG1570	exodeoxyribonuclease VII activity
TOPB45_1422	COG0489	protein tyrosine kinase activity
TOPB45_1426	COG1959	2 iron, 2 sulfur cluster binding
TOPB45_1427	COG1294	oxidase, subunit
TOPB45_1428	COG1271	oxidase subunit
TOPB45_1433	COG0495	leucyl-tRNA aminoacylation
TOPB45_1434	COG0538	isocitrate dehydrogenase activity
TOPB45_1435	COG1573	uracil-dna glycosylase
TOPB45_1436	COG1030	water channel activity
TOPB45_1438	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
TOPB45_1440	COG1362	aminopeptidase activity
TOPB45_1442	COG0268	Binds directly to 16S ribosomal RNA
TOPB45_1444	COG0521	Mo-molybdopterin cofactor biosynthetic process
TOPB45_1446	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
TOPB45_1450	COG0437	4 iron, 4 sulfur cluster binding
TOPB45_1452	COG1663	tetraacyldisaccharide 4'-kinase activity
TOPB45_1455	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TOPB45_1457	COG0181	hydroxymethylbilane synthase activity
TOPB45_1459	COG0247	lactate metabolic process
TOPB45_1461	COG1253	flavin adenine dinucleotide binding
TOPB45_1462	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TOPB45_1463	COG0163	prenyltransferase activity
TOPB45_1464	COG0328	RNA-DNA hybrid ribonuclease activity
TOPB45_1468	COG0835	chemotaxis
TOPB45_1469	COG0643	Histidine kinase
TOPB45_1469	COG2198	Histidine kinase
TOPB45_1470	COG1619	proteins homologs of microcin C7 resistance protein MccF
TOPB45_1471	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TOPB45_1472	COG2264	protein methyltransferase activity
TOPB45_1476	COG0077	Prephenate dehydratase
TOPB45_1476	COG1605	Chorismate mutase
TOPB45_1478	COG0195	Participates in both transcription termination and antitermination
TOPB45_1479	COG0779	Required for maturation of 30S ribosomal subunits
TOPB45_1481	COG0477	Major facilitator Superfamily
TOPB45_1482	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TOPB45_1484	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
TOPB45_1485	COG0592	DNA-directed DNA polymerase activity
TOPB45_1486	COG0187	DNA topoisomerase II activity
TOPB45_1489	COG5557	Pfam Polysulphide reductase, NrfD
TOPB45_1490	COG0437	4 iron, 4 sulfur cluster binding
TOPB45_1490	COG3064	Membrane
TOPB45_1492	COG0484	heat shock protein binding
TOPB45_1496	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TOPB45_1497	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TOPB45_1497	COG1796	DNA polymerase
TOPB45_1498	COG1686	Belongs to the peptidase S11 family
TOPB45_1499	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TOPB45_1500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TOPB45_1501	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TOPB45_1503	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TOPB45_1505	COG0138	bifunctional purine biosynthesis protein purh
TOPB45_1506	COG0535	radical SAM domain protein
TOPB45_1508	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TOPB45_1509	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TOPB45_1516	COG0482	sulfurtransferase activity
TOPB45_1517	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TOPB45_1518	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TOPB45_1519	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TOPB45_1521	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TOPB45_1524	COG1596	polysaccharide export
TOPB45_1524	COG1555	photosystem II stabilization
TOPB45_1525	COG2920	part of a sulfur-relay system
TOPB45_1528	COG0018	arginyl-trna synthetase
TOPB45_1530	COG0564	pseudouridine synthase activity
TOPB45_1532	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TOPB45_1533	COG0443	Heat shock 70 kDa protein
TOPB45_1534	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TOPB45_1535	COG0157	Belongs to the NadC ModD family
TOPB45_1536	COG1227	inorganic diphosphatase activity
TOPB45_1540	COG1160	GTP binding
TOPB45_1543	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TOPB45_1545	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TOPB45_1546	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TOPB45_1547	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TOPB45_1548	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TOPB45_1549	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TOPB45_1552	COG0772	Belongs to the SEDS family
TOPB45_1553	COG0768	penicillin binding
TOPB45_1555	COG1792	Involved in formation and maintenance of cell shape
TOPB45_1558	COG1234	tRNA 3'-trailer cleavage
TOPB45_1561	COG0436	Aminotransferase
TOPB45_1562	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TOPB45_1568	COG1706	bacterial-type flagellum-dependent cell motility
TOPB45_1569	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
TOPB45_1572	COG4786	Flagellar basal body rod
TOPB45_1573	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TOPB45_1576	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TOPB45_1580	COG1278	Cold shock
TOPB45_1582	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
TOPB45_1583	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TOPB45_1584	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TOPB45_1589	COG0504	CTP synthase activity
TOPB45_1591	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TOPB45_1594	COG1418	mRNA catabolic process
TOPB45_1595	COG1692	metallophosphoesterase
TOPB45_1596	COG0242	peptide deformylase activity
TOPB45_1597	COG1028	Short-chain dehydrogenase reductase Sdr
TOPB45_1598	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TOPB45_1600	COG0674	pyruvate-flavodoxin oxidoreductase activity
TOPB45_1601	COG1013	pyruvate-flavodoxin oxidoreductase activity
TOPB45_1602	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TOPB45_1604	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TOPB45_1606	COG0735	belongs to the Fur family
TOPB45_1607	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TOPB45_1609	COG0009	L-threonylcarbamoyladenylate synthase
TOPB45_1613	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TOPB45_1614	COG0805	protein transport
TOPB45_1615	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TOPB45_1616	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TOPB45_1617	COG0492	ferredoxin-NADP+ reductase activity
TOPB45_1620	COG0165	Argininosuccinate lyase
TOPB45_1625	COG1959	2 iron, 2 sulfur cluster binding
TOPB45_1626	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TOPB45_1627	COG1525	nuclease
TOPB45_1629	COG1516	flagellar protein fliS
TOPB45_1632	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TOPB45_1634	COG0444	Belongs to the ABC transporter superfamily
TOPB45_1635	COG4608	Belongs to the ABC transporter superfamily