TOPB45_0038 6758dee7eea997d2b71ed53ae187143a 88 Gene3D G3DSA:3.90.940.10 1 85 5.7E-21 T 13-10-2018 IPR012293 RNA polymerase subunit, RPB6/omega GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6|Reactome: R-HSA-112382|Reactome: R-HSA-113418|Reactome: R-HSA-167152|Reactome: R-HSA-167158|Reactome: R-HSA-167160|Reactome: R-HSA-167161|Reactome: R-HSA-167162|Reactome: R-HSA-167172|Reactome: R-HSA-167200|Reactome: R-HSA-167238|Reactome: R-HSA-167242|Reactome: R-HSA-167243|Reactome: R-HSA-167246|Reactome: R-HSA-167287|Reactome: R-HSA-167290|Reactome: R-HSA-168325|Reactome: R-HSA-1834949|Reactome: R-HSA-203927|Reactome: R-HSA-427413|Reactome: R-HSA-452723|Reactome: R-HSA-5250924|Reactome: R-HSA-5578749|Reactome: R-HSA-5601884|Reactome: R-HSA-5617472|Reactome: R-HSA-674695|Reactome: R-HSA-6781823|Reactome: R-HSA-6781827|Reactome: R-HSA-6782135|Reactome: R-HSA-6782210|Reactome: R-HSA-6796648|Reactome: R-HSA-6803529|Reactome: R-HSA-6807505|Reactome: R-HSA-72086|Reactome: R-HSA-72163|Reactome: R-HSA-72165|Reactome: R-HSA-72203|Reactome: R-HSA-73762|Reactome: R-HSA-73772|Reactome: R-HSA-73776|Reactome: R-HSA-73777|Reactome: R-HSA-73779|Reactome: R-HSA-73780|Reactome: R-HSA-73863|Reactome: R-HSA-73980|Reactome: R-HSA-749476|Reactome: R-HSA-75953|Reactome: R-HSA-75955|Reactome: R-HSA-76042|Reactome: R-HSA-76061|Reactome: R-HSA-76066|Reactome: R-HSA-76071|Reactome: R-HSA-77075|Reactome: R-HSA-8851708|Reactome: R-HSA-9018519 TOPB45_0038 6758dee7eea997d2b71ed53ae187143a 88 SMART SM01409 8 59 8.3E-12 T 13-10-2018 IPR006110 RNA polymerase, subunit omega/K/RPB6 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6|Reactome: R-HSA-112382|Reactome: R-HSA-113418|Reactome: R-HSA-167152|Reactome: R-HSA-167158|Reactome: R-HSA-167160|Reactome: R-HSA-167161|Reactome: R-HSA-167162|Reactome: R-HSA-167172|Reactome: R-HSA-167200|Reactome: R-HSA-167238|Reactome: R-HSA-167242|Reactome: R-HSA-167243|Reactome: R-HSA-167246|Reactome: R-HSA-167287|Reactome: R-HSA-167290|Reactome: R-HSA-168325|Reactome: R-HSA-1834949|Reactome: R-HSA-203927|Reactome: R-HSA-427413|Reactome: R-HSA-452723|Reactome: R-HSA-5250924|Reactome: R-HSA-5578749|Reactome: R-HSA-5601884|Reactome: R-HSA-5617472|Reactome: R-HSA-674695|Reactome: R-HSA-6781823|Reactome: R-HSA-6781827|Reactome: R-HSA-6782135|Reactome: R-HSA-6782210|Reactome: R-HSA-6796648|Reactome: R-HSA-6803529|Reactome: R-HSA-6807505|Reactome: R-HSA-72086|Reactome: R-HSA-72163|Reactome: R-HSA-72165|Reactome: R-HSA-72203|Reactome: R-HSA-73762|Reactome: R-HSA-73772|Reactome: R-HSA-73776|Reactome: R-HSA-73777|Reactome: R-HSA-73779|Reactome: R-HSA-73780|Reactome: R-HSA-73863|Reactome: R-HSA-73980|Reactome: R-HSA-749476|Reactome: R-HSA-75953|Reactome: R-HSA-75955|Reactome: R-HSA-76042|Reactome: R-HSA-76061|Reactome: R-HSA-76066|Reactome: R-HSA-76071|Reactome: R-HSA-77075|Reactome: R-HSA-8851708|Reactome: R-HSA-9018519 TOPB45_0038 6758dee7eea997d2b71ed53ae187143a 88 TIGRFAM TIGR00690 rpoZ: DNA-directed RNA polymerase, omega subunit 1 57 6.8E-16 T 13-10-2018 IPR003716 DNA-directed RNA polymerase, omega subunit GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TOPB45_0038 6758dee7eea997d2b71ed53ae187143a 88 SUPERFAMILY SSF63562 1 67 6.45E-18 T 13-10-2018 IPR036161 RPB6/omega subunit-like superfamily GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6|Reactome: R-HSA-112382|Reactome: R-HSA-113418|Reactome: R-HSA-167152|Reactome: R-HSA-167158|Reactome: R-HSA-167160|Reactome: R-HSA-167161|Reactome: R-HSA-167162|Reactome: R-HSA-167172|Reactome: R-HSA-167200|Reactome: R-HSA-167238|Reactome: R-HSA-167242|Reactome: R-HSA-167243|Reactome: R-HSA-167246|Reactome: R-HSA-167287|Reactome: R-HSA-167290|Reactome: R-HSA-168325|Reactome: R-HSA-1834949|Reactome: R-HSA-203927|Reactome: R-HSA-427413|Reactome: R-HSA-452723|Reactome: R-HSA-5250924|Reactome: R-HSA-5578749|Reactome: R-HSA-5601884|Reactome: R-HSA-5617472|Reactome: R-HSA-674695|Reactome: R-HSA-6781823|Reactome: R-HSA-6781827|Reactome: R-HSA-6782135|Reactome: R-HSA-6782210|Reactome: R-HSA-6796648|Reactome: R-HSA-6803529|Reactome: R-HSA-6807505|Reactome: R-HSA-72086|Reactome: R-HSA-72163|Reactome: R-HSA-72165|Reactome: R-HSA-72203|Reactome: R-HSA-73762|Reactome: R-HSA-73772|Reactome: R-HSA-73776|Reactome: R-HSA-73777|Reactome: R-HSA-73779|Reactome: R-HSA-73780|Reactome: R-HSA-73863|Reactome: R-HSA-73980|Reactome: R-HSA-749476|Reactome: R-HSA-75953|Reactome: R-HSA-75955|Reactome: R-HSA-76042|Reactome: R-HSA-76061|Reactome: R-HSA-76066|Reactome: R-HSA-76071|Reactome: R-HSA-77075|Reactome: R-HSA-8851708|Reactome: R-HSA-9018519 TOPB45_0038 6758dee7eea997d2b71ed53ae187143a 88 Hamap MF_00366 DNA-directed RNA polymerase subunit omega [rpoZ]. 1 60 15.555 T 13-10-2018 IPR003716 DNA-directed RNA polymerase, omega subunit GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TOPB45_0038 6758dee7eea997d2b71ed53ae187143a 88 Pfam PF01192 RNA polymerase Rpb6 8 58 1.6E-12 T 13-10-2018 IPR006110 RNA polymerase, subunit omega/K/RPB6 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6|Reactome: R-HSA-112382|Reactome: R-HSA-113418|Reactome: R-HSA-167152|Reactome: R-HSA-167158|Reactome: R-HSA-167160|Reactome: R-HSA-167161|Reactome: R-HSA-167162|Reactome: R-HSA-167172|Reactome: R-HSA-167200|Reactome: R-HSA-167238|Reactome: R-HSA-167242|Reactome: R-HSA-167243|Reactome: R-HSA-167246|Reactome: R-HSA-167287|Reactome: R-HSA-167290|Reactome: R-HSA-168325|Reactome: R-HSA-1834949|Reactome: R-HSA-203927|Reactome: R-HSA-427413|Reactome: R-HSA-452723|Reactome: R-HSA-5250924|Reactome: R-HSA-5578749|Reactome: R-HSA-5601884|Reactome: R-HSA-5617472|Reactome: R-HSA-674695|Reactome: R-HSA-6781823|Reactome: R-HSA-6781827|Reactome: R-HSA-6782135|Reactome: R-HSA-6782210|Reactome: R-HSA-6796648|Reactome: R-HSA-6803529|Reactome: R-HSA-6807505|Reactome: R-HSA-72086|Reactome: R-HSA-72163|Reactome: R-HSA-72165|Reactome: R-HSA-72203|Reactome: R-HSA-73762|Reactome: R-HSA-73772|Reactome: R-HSA-73776|Reactome: R-HSA-73777|Reactome: R-HSA-73779|Reactome: R-HSA-73780|Reactome: R-HSA-73863|Reactome: R-HSA-73980|Reactome: R-HSA-749476|Reactome: R-HSA-75953|Reactome: R-HSA-75955|Reactome: R-HSA-76042|Reactome: R-HSA-76061|Reactome: R-HSA-76066|Reactome: R-HSA-76071|Reactome: R-HSA-77075|Reactome: R-HSA-8851708|Reactome: R-HSA-9018519 TOPB45_0424 9688a6e39e538b92b9ded7c76a125090 530 Gene3D G3DSA:1.10.3210.10 4 270 2.3E-28 T 13-10-2018 TOPB45_0424 9688a6e39e538b92b9ded7c76a125090 530 Pfam PF08668 HDOD domain 35 205 1.1E-19 T 13-10-2018 IPR013976 Metal-dependent hydrolase HDOD TOPB45_0424 9688a6e39e538b92b9ded7c76a125090 530 Gene3D G3DSA:3.30.70.270 340 485 1.3E-25 T 13-10-2018 TOPB45_0424 9688a6e39e538b92b9ded7c76a125090 530 SUPERFAMILY SSF109604 11 273 7.85E-24 T 13-10-2018 TOPB45_0424 9688a6e39e538b92b9ded7c76a125090 530 TIGRFAM TIGR00254 GGDEF: diguanylate cyclase (GGDEF) domain 347 468 8.2E-21 T 13-10-2018 IPR000160 GGDEF domain TOPB45_0424 9688a6e39e538b92b9ded7c76a125090 530 Pfam PF00990 Diguanylate cyclase, GGDEF domain 351 474 1.6E-21 T 13-10-2018 IPR000160 GGDEF domain TOPB45_0424 9688a6e39e538b92b9ded7c76a125090 530 SUPERFAMILY SSF55073 355 464 7.77E-21 T 13-10-2018 IPR029787 Nucleotide cyclase TOPB45_0424 9688a6e39e538b92b9ded7c76a125090 530 SMART SM00267 339 514 5.9E-16 T 13-10-2018 IPR000160 GGDEF domain TOPB45_1226 7a6ddb02e9769ddd99888109a991c842 324 TIGRFAM TIGR00287 cas1: CRISPR-associated endonuclease Cas1 6 319 2.6E-93 T 13-10-2018 IPR002729 CRISPR-associated protein Cas1 GO:0003676|GO:0004519|GO:0043571|GO:0046872|GO:0051607 TOPB45_1226 7a6ddb02e9769ddd99888109a991c842 324 Pfam PF01867 CRISPR associated protein Cas1 6 278 1.3E-86 T 13-10-2018 IPR002729 CRISPR-associated protein Cas1 GO:0003676|GO:0004519|GO:0043571|GO:0046872|GO:0051607 TOPB45_1226 7a6ddb02e9769ddd99888109a991c842 324 Hamap MF_01470 CRISPR-associated endonuclease Cas1 [cas1]. 3 309 25.342 T 13-10-2018 IPR002729 CRISPR-associated protein Cas1 GO:0003676|GO:0004519|GO:0043571|GO:0046872|GO:0051607 TOPB45_1226 7a6ddb02e9769ddd99888109a991c842 324 Gene3D G3DSA:1.20.120.920 83 323 3.6E-66 T 13-10-2018 TOPB45_1226 7a6ddb02e9769ddd99888109a991c842 324 Gene3D G3DSA:3.100.10.20 1 81 4.1E-33 T 13-10-2018 TOPB45_1226 7a6ddb02e9769ddd99888109a991c842 324 TIGRFAM TIGR03641 cas1_HMARI: CRISPR-associated endonuclease Cas1, subtype I-B/HMARI/TNEAP 4 324 1.9E-135 T 13-10-2018 IPR019858 CRISPR-associated protein Cas1, HMARI/TNEAP subtype GO:0004520|GO:0043571|GO:0046872 TOPB45_0171 a19ac66c67412ec43171c238fa94da67 56 TIGRFAM TIGR01023 rpmG_bact: ribosomal protein bL33 1 55 5.3E-26 T 13-10-2018 IPR001705 Ribosomal protein L33 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0171 a19ac66c67412ec43171c238fa94da67 56 ProSitePatterns PS00582 Ribosomal protein L33 signature. 23 42 - T 13-10-2018 IPR018264 Ribosomal protein L33, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0171 a19ac66c67412ec43171c238fa94da67 56 Hamap MF_00294 50S ribosomal protein L33 [rpmG]. 7 55 19.096 T 13-10-2018 IPR001705 Ribosomal protein L33 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0171 a19ac66c67412ec43171c238fa94da67 56 Pfam PF00471 Ribosomal protein L33 9 55 1.8E-24 T 13-10-2018 IPR001705 Ribosomal protein L33 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0171 a19ac66c67412ec43171c238fa94da67 56 SUPERFAMILY SSF57829 4 55 8.55E-21 T 13-10-2018 IPR011332 Zinc-binding ribosomal protein GO:0006412 TOPB45_0171 a19ac66c67412ec43171c238fa94da67 56 Gene3D G3DSA:2.20.28.120 2 55 6.7E-25 T 13-10-2018 IPR038584 Ribosomal protein L33 superfamily Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0003 5fbec2bc051bf327a9c6d5dac68898d8 251 SUPERFAMILY SSF52402 3 220 1.46E-43 T 13-10-2018 TOPB45_0003 5fbec2bc051bf327a9c6d5dac68898d8 251 Gene3D G3DSA:3.40.50.620 2 246 1.2E-42 T 13-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TOPB45_0003 5fbec2bc051bf327a9c6d5dac68898d8 251 PIRSF PIRSF004976 2 248 5.4E-51 T 13-10-2018 IPR035107 tRNA thiolation protein, TtcA/Ctu1 type GO:0008033 Reactome: R-HSA-6782315 TOPB45_0003 5fbec2bc051bf327a9c6d5dac68898d8 251 Pfam PF01171 PP-loop family 27 208 4.1E-20 T 13-10-2018 IPR011063 tRNA(Ile)-lysidine/2-thiocytidine synthase, N-terminal Reactome: R-HSA-6782315 TOPB45_0234 921f41072a02e7ee2c46c3d737a3f629 279 TIGRFAM TIGR00722 ttdA_fumA_fumB: hydrolyase, tartrate alpha subunit/fumarate domain protein, Fe-S type 13 273 8.9E-102 T 13-10-2018 IPR004646 Fe-S hydro-lyase, tartrate dehydratase alpha-type, catalytic domain GO:0016829 TOPB45_0234 921f41072a02e7ee2c46c3d737a3f629 279 Pfam PF05681 Fumarate hydratase (Fumerase) 13 275 4.6E-110 T 13-10-2018 IPR004646 Fe-S hydro-lyase, tartrate dehydratase alpha-type, catalytic domain GO:0016829 TOPB45_0978 2ec505eb8c683d168d3a57c1899a8de7 231 Pfam PF14824 Sirohaem biosynthesis protein central 121 147 6.2E-8 T 13-10-2018 IPR028281 Siroheme synthase, central domain KEGG: 00860+4.99.1.4+1.3.1.76+2.1.1.107|MetaCyc: PWY-5194|MetaCyc: PWY-5196|MetaCyc: PWY-7377 TOPB45_0978 2ec505eb8c683d168d3a57c1899a8de7 231 Gene3D G3DSA:3.40.50.720 5 132 1.1E-45 T 13-10-2018 TOPB45_0978 2ec505eb8c683d168d3a57c1899a8de7 231 Gene3D G3DSA:1.10.8.610 133 202 6.5E-7 T 13-10-2018 TOPB45_0978 2ec505eb8c683d168d3a57c1899a8de7 231 TIGRFAM TIGR01470 cysG_Nterm: siroheme synthase, N-terminal domain 6 173 2.5E-50 T 13-10-2018 IPR006367 Sirohaem synthase, N-terminal GO:0006779|GO:0019354|GO:0055114 KEGG: 00860+4.99.1.4+1.3.1.76+2.1.1.107|MetaCyc: PWY-5194|MetaCyc: PWY-5196|MetaCyc: PWY-7377 TOPB45_0978 2ec505eb8c683d168d3a57c1899a8de7 231 SUPERFAMILY SSF51735 5 114 8.44E-26 T 13-10-2018 IPR036291 NAD(P)-binding domain superfamily TOPB45_0978 2ec505eb8c683d168d3a57c1899a8de7 231 SUPERFAMILY SSF75615 110 185 5.49E-17 T 13-10-2018 TOPB45_0978 2ec505eb8c683d168d3a57c1899a8de7 231 Pfam PF13241 Putative NAD(P)-binding 8 117 3.7E-32 T 13-10-2018 TOPB45_0036 f872cb417831bee3fe360d88e487f3fd 551 SUPERFAMILY SSF143975 1 371 1.83E-145 T 13-10-2018 IPR037237 IlvD/EDD, N-terminal domain KEGG: 00290+4.2.1.9|KEGG: 00770+4.2.1.9|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-7111 TOPB45_0036 f872cb417831bee3fe360d88e487f3fd 551 Hamap MF_00012 Dihydroxy-acid dehydratase [ilvD]. 1 551 48.917 T 13-10-2018 IPR004404 Dihydroxy-acid dehydratase GO:0004160|GO:0009082 KEGG: 00290+4.2.1.9|KEGG: 00770+4.2.1.9|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-7111 TOPB45_0036 f872cb417831bee3fe360d88e487f3fd 551 Pfam PF00920 Dehydratase family 31 548 1.7E-233 T 13-10-2018 IPR000581 Dihydroxy-acid/6-phosphogluconate dehydratase GO:0003824 KEGG: 00290+4.2.1.9|KEGG: 00770+4.2.1.9|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-7111 TOPB45_0036 f872cb417831bee3fe360d88e487f3fd 551 TIGRFAM TIGR00110 ilvD: dihydroxy-acid dehydratase 14 550 2.1E-253 T 13-10-2018 IPR004404 Dihydroxy-acid dehydratase GO:0004160|GO:0009082 KEGG: 00290+4.2.1.9|KEGG: 00770+4.2.1.9|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-7111 TOPB45_0036 f872cb417831bee3fe360d88e487f3fd 551 ProSitePatterns PS00887 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 2. 460 471 - T 13-10-2018 IPR020558 Dihydroxy-acid/6-phosphogluconate dehydratase, conserved site GO:0003824 KEGG: 00290+4.2.1.9|KEGG: 00770+4.2.1.9|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-7111 TOPB45_0036 f872cb417831bee3fe360d88e487f3fd 551 ProSitePatterns PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1. 119 129 - T 13-10-2018 IPR020558 Dihydroxy-acid/6-phosphogluconate dehydratase, conserved site GO:0003824 KEGG: 00290+4.2.1.9|KEGG: 00770+4.2.1.9|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-7111 TOPB45_0036 f872cb417831bee3fe360d88e487f3fd 551 SUPERFAMILY SSF52016 372 550 1.88E-63 T 13-10-2018 TOPB45_0036 f872cb417831bee3fe360d88e487f3fd 551 Gene3D G3DSA:3.50.30.80 372 523 9.2E-61 T 13-10-2018 TOPB45_0916 dce24d9da66b77b195b5b11a5960d951 546 SUPERFAMILY SSF160246 3 141 4.58E-35 T 13-10-2018 IPR037257 General secretory system II, protein E, N-terminal superfamily TOPB45_0916 dce24d9da66b77b195b5b11a5960d951 546 Pfam PF05157 Type II secretion system (T2SS), protein E, N-terminal domain 39 141 6.3E-22 T 13-10-2018 IPR007831 General secretory system II, protein E, N-terminal TOPB45_0916 dce24d9da66b77b195b5b11a5960d951 546 Gene3D G3DSA:3.40.50.300 278 546 3.4E-103 T 13-10-2018 TOPB45_0916 dce24d9da66b77b195b5b11a5960d951 546 SUPERFAMILY SSF52540 170 545 1.04E-85 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0916 dce24d9da66b77b195b5b11a5960d951 546 ProSitePatterns PS00662 Bacterial type II secretion system protein E signature. 369 383 - T 13-10-2018 IPR001482 Type II/IV secretion system protein TOPB45_0916 dce24d9da66b77b195b5b11a5960d951 546 Pfam PF00437 Type II/IV secretion system protein 183 441 1.2E-66 T 13-10-2018 IPR001482 Type II/IV secretion system protein TOPB45_0916 dce24d9da66b77b195b5b11a5960d951 546 Gene3D G3DSA:3.30.300.160 60 141 1.8E-12 T 13-10-2018 TOPB45_0916 dce24d9da66b77b195b5b11a5960d951 546 Gene3D G3DSA:3.30.450.90 145 273 7.0E-32 T 13-10-2018 TOPB45_1049 a1923c08f3b81e8861808db1b570eb52 1128 SUPERFAMILY SSF53335 215 847 6.38E-52 T 13-10-2018 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TOPB45_1049 a1923c08f3b81e8861808db1b570eb52 1128 PRINTS PR00507 N12 class N6 adenine-specific DNA methyltransferase signature 734 746 3.1E-17 T 13-10-2018 TOPB45_1049 a1923c08f3b81e8861808db1b570eb52 1128 PRINTS PR00507 N12 class N6 adenine-specific DNA methyltransferase signature 433 449 3.1E-17 T 13-10-2018 TOPB45_1049 a1923c08f3b81e8861808db1b570eb52 1128 PRINTS PR00507 N12 class N6 adenine-specific DNA methyltransferase signature 770 794 3.1E-17 T 13-10-2018 TOPB45_1049 a1923c08f3b81e8861808db1b570eb52 1128 PRINTS PR00507 N12 class N6 adenine-specific DNA methyltransferase signature 496 510 3.1E-17 T 13-10-2018 TOPB45_1049 a1923c08f3b81e8861808db1b570eb52 1128 ProSitePatterns PS00092 N-6 Adenine-specific DNA methylases signature. 737 743 - T 13-10-2018 IPR002052 DNA methylase, N-6 adenine-specific, conserved site GO:0003676|GO:0008168|GO:0032259 TOPB45_0966 95a511b691bde9dd31ee0a9389694c46 445 Pfam PF13176 Tetratricopeptide repeat 337 357 0.023 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_0966 95a511b691bde9dd31ee0a9389694c46 445 SUPERFAMILY SSF48452 233 431 2.09E-24 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_0966 95a511b691bde9dd31ee0a9389694c46 445 Gene3D G3DSA:1.25.40.10 363 445 1.3E-16 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_0966 95a511b691bde9dd31ee0a9389694c46 445 SMART SM00028 399 432 0.68 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_0966 95a511b691bde9dd31ee0a9389694c46 445 SMART SM00028 366 398 2.2E-4 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_0966 95a511b691bde9dd31ee0a9389694c46 445 SMART SM00028 295 328 20.0 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_0966 95a511b691bde9dd31ee0a9389694c46 445 SMART SM00028 332 365 36.0 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_0966 95a511b691bde9dd31ee0a9389694c46 445 SMART SM00028 229 262 0.43 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_0966 95a511b691bde9dd31ee0a9389694c46 445 Gene3D G3DSA:1.25.40.10 295 362 2.9E-8 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_0966 95a511b691bde9dd31ee0a9389694c46 445 Pfam PF00515 Tetratricopeptide repeat 367 396 3.1E-9 T 13-10-2018 IPR001440 Tetratricopeptide repeat 1 GO:0005515 TOPB45_0966 95a511b691bde9dd31ee0a9389694c46 445 Gene3D G3DSA:1.25.40.10 221 294 8.0E-8 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_0087 7d6b40c8c68325d170dbb28ff593e454 467 ProSitePatterns PS00588 Flagella basal body rod proteins signature. 13 33 - T 13-10-2018 IPR019776 Flagellar basal body rod protein, conserved site TOPB45_0087 7d6b40c8c68325d170dbb28ff593e454 467 SUPERFAMILY SSF117143 83 428 3.66E-43 T 13-10-2018 IPR037925 Flagellar hook-basal body protein, FlgE/F/G-like TOPB45_0087 7d6b40c8c68325d170dbb28ff593e454 467 Pfam PF07559 Flagellar basal body protein FlaE 198 347 2.6E-9 T 13-10-2018 IPR011491 Flagellar hook protein FlgE TOPB45_0087 7d6b40c8c68325d170dbb28ff593e454 467 Pfam PF00460 Flagella basal body rod protein 21 37 2.0E-5 T 13-10-2018 IPR001444 Flagellar basal body rod protein, N-terminal GO:0071973 TOPB45_0087 7d6b40c8c68325d170dbb28ff593e454 467 TIGRFAM TIGR03506 FlgEFG_subfam: flagellar hook-basal body protein 6 449 6.1E-63 T 13-10-2018 IPR020013 Flagellar hook-basal body protein, FlgE/F/G TOPB45_0087 7d6b40c8c68325d170dbb28ff593e454 467 Pfam PF06429 Flagellar basal body rod FlgEFG protein C-terminal 390 461 6.2E-18 T 13-10-2018 IPR010930 Flagellar basal-body/hook protein, C-terminal domain TOPB45_0473 4cc35395fd911c8aba3c3aa225697515 545 Gene3D G3DSA:3.40.1010.20 3 274 2.0E-90 T 13-10-2018 TOPB45_0473 4cc35395fd911c8aba3c3aa225697515 545 Gene3D G3DSA:3.40.50.11270 12 95 2.0E-90 T 13-10-2018 TOPB45_0473 4cc35395fd911c8aba3c3aa225697515 545 TIGRFAM TIGR00216 ispH_lytB: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 2 275 1.5E-83 T 13-10-2018 IPR003451 4-hydroxy-3-methylbut-2-enyl diphosphate reductase GO:0019288|GO:0046872|GO:0050992|GO:0051745 KEGG: 00900+1.17.7.4|MetaCyc: PWY-7560 TOPB45_0473 4cc35395fd911c8aba3c3aa225697515 545 Gene3D G3DSA:3.40.1010.20 96 188 2.0E-90 T 13-10-2018 TOPB45_0473 4cc35395fd911c8aba3c3aa225697515 545 Pfam PF02401 LytB protein 3 274 1.7E-85 T 13-10-2018 IPR003451 4-hydroxy-3-methylbut-2-enyl diphosphate reductase GO:0019288|GO:0046872|GO:0050992|GO:0051745 KEGG: 00900+1.17.7.4|MetaCyc: PWY-7560 TOPB45_0473 4cc35395fd911c8aba3c3aa225697515 545 Hamap MF_00191 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [ispH]. 1 278 30.547 T 13-10-2018 IPR003451 4-hydroxy-3-methylbut-2-enyl diphosphate reductase GO:0019288|GO:0046872|GO:0050992|GO:0051745 KEGG: 00900+1.17.7.4|MetaCyc: PWY-7560 TOPB45_0610 401dc93f0f1b569cab115a50b7424fd3 338 SUPERFAMILY SSF51735 109 252 2.56E-37 T 13-10-2018 IPR036291 NAD(P)-binding domain superfamily TOPB45_0610 401dc93f0f1b569cab115a50b7424fd3 338 Gene3D G3DSA:1.10.287.70 3 111 3.1E-18 T 13-10-2018 TOPB45_0610 401dc93f0f1b569cab115a50b7424fd3 338 Pfam PF07885 Ion channel 17 89 1.3E-12 T 13-10-2018 IPR013099 Potassium channel domain TOPB45_0610 401dc93f0f1b569cab115a50b7424fd3 338 SUPERFAMILY SSF116726 238 327 1.83E-17 T 13-10-2018 IPR036721 Regulator of K+ conductance, C-terminal domain superfamily GO:0006813 TOPB45_0610 401dc93f0f1b569cab115a50b7424fd3 338 Pfam PF02080 TrkA-C domain 262 327 2.1E-12 T 13-10-2018 IPR006037 Regulator of K+ conductance, C-terminal GO:0006813|GO:0008324 TOPB45_0610 401dc93f0f1b569cab115a50b7424fd3 338 Gene3D G3DSA:3.40.50.720 112 257 2.8E-36 T 13-10-2018 TOPB45_0610 401dc93f0f1b569cab115a50b7424fd3 338 Pfam PF02254 TrkA-N domain 113 226 4.8E-29 T 13-10-2018 IPR003148 Regulator of K+ conductance, N-terminal GO:0006813 TOPB45_0610 401dc93f0f1b569cab115a50b7424fd3 338 SUPERFAMILY SSF81324 8 129 1.19E-19 T 13-10-2018 TOPB45_0610 401dc93f0f1b569cab115a50b7424fd3 338 Gene3D G3DSA:3.30.70.1450 258 338 3.3E-19 T 13-10-2018 IPR036721 Regulator of K+ conductance, C-terminal domain superfamily GO:0006813 TOPB45_1427 cddd699224d6833073b45629b902945c 340 PIRSF PIRSF000267 1 340 6.0E-122 T 13-10-2018 IPR003317 Cytochrome ubiquinol oxidase subunit 2 GO:0016020|GO:0055114 TOPB45_1427 cddd699224d6833073b45629b902945c 340 Pfam PF02322 Cytochrome bd terminal oxidase subunit II 4 326 2.5E-102 T 13-10-2018 IPR003317 Cytochrome ubiquinol oxidase subunit 2 GO:0016020|GO:0055114 TOPB45_1427 cddd699224d6833073b45629b902945c 340 TIGRFAM TIGR00203 cydB: cytochrome d ubiquinol oxidase, subunit II 4 216 2.4E-61 T 13-10-2018 IPR003317 Cytochrome ubiquinol oxidase subunit 2 GO:0016020|GO:0055114 TOPB45_0944 f91b7246f6327d2e1ecd6596d2cdfe30 464 Pfam PF01225 Mur ligase family, catalytic domain 6 103 8.5E-28 T 13-10-2018 IPR000713 Mur ligase, N-terminal catalytic domain GO:0005524|GO:0009058 TOPB45_0944 f91b7246f6327d2e1ecd6596d2cdfe30 464 Gene3D G3DSA:3.40.50.720 5 91 2.8E-33 T 13-10-2018 TOPB45_0944 f91b7246f6327d2e1ecd6596d2cdfe30 464 Pfam PF08245 Mur ligase middle domain 110 287 1.0E-27 T 13-10-2018 IPR013221 Mur ligase, central GO:0005524|GO:0009058 TOPB45_0944 f91b7246f6327d2e1ecd6596d2cdfe30 464 Gene3D G3DSA:3.40.1190.10 93 305 5.8E-66 T 13-10-2018 IPR036565 Mur-like, catalytic domain superfamily GO:0005524|GO:0009058 Reactome: R-HSA-196757 TOPB45_0944 f91b7246f6327d2e1ecd6596d2cdfe30 464 Hamap MF_00046 UDP-N-acetylmuramate--L-alanine ligase [murC]. 4 457 38.581 T 13-10-2018 IPR005758 UDP-N-acetylmuramate--L-alanine ligase GO:0008763|GO:0009252 KEGG: 00471+6.3.2.8|KEGG: 00550+6.3.2.8|MetaCyc: PWY-6386|MetaCyc: PWY-6387|MetaCyc: PWY-7953 TOPB45_0944 f91b7246f6327d2e1ecd6596d2cdfe30 464 SUPERFAMILY SSF51984 5 91 4.97E-29 T 13-10-2018 TOPB45_0944 f91b7246f6327d2e1ecd6596d2cdfe30 464 SUPERFAMILY SSF53623 90 306 1.31E-59 T 13-10-2018 IPR036565 Mur-like, catalytic domain superfamily GO:0005524|GO:0009058 Reactome: R-HSA-196757 TOPB45_0944 f91b7246f6327d2e1ecd6596d2cdfe30 464 Pfam PF02875 Mur ligase family, glutamate ligase domain 308 394 2.3E-19 T 13-10-2018 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 TOPB45_0944 f91b7246f6327d2e1ecd6596d2cdfe30 464 Gene3D G3DSA:3.90.190.20 306 463 6.5E-50 T 13-10-2018 IPR036615 Mur ligase, C-terminal domain superfamily GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 TOPB45_0944 f91b7246f6327d2e1ecd6596d2cdfe30 464 SUPERFAMILY SSF53244 307 453 6.04E-41 T 13-10-2018 IPR036615 Mur ligase, C-terminal domain superfamily GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 TOPB45_0944 f91b7246f6327d2e1ecd6596d2cdfe30 464 TIGRFAM TIGR01082 murC: UDP-N-acetylmuramate--L-alanine ligase 6 451 4.8E-151 T 13-10-2018 IPR005758 UDP-N-acetylmuramate--L-alanine ligase GO:0008763|GO:0009252 KEGG: 00471+6.3.2.8|KEGG: 00550+6.3.2.8|MetaCyc: PWY-6386|MetaCyc: PWY-6387|MetaCyc: PWY-7953 TOPB45_1003 73ab8f0999e65c10d443dba7b714c300 255 Gene3D G3DSA:3.20.20.150 5 254 2.0E-52 T 13-10-2018 TOPB45_1003 73ab8f0999e65c10d443dba7b714c300 255 SUPERFAMILY SSF51658 44 253 3.14E-35 T 13-10-2018 IPR036237 Xylose isomerase-like superfamily TOPB45_1003 73ab8f0999e65c10d443dba7b714c300 255 Pfam PF01261 Xylose isomerase-like TIM barrel 45 216 7.4E-15 T 13-10-2018 IPR013022 Xylose isomerase-like, TIM barrel domain TOPB45_1541 92f462fae28f284f5663d6c09b1a9588 144 ProDom PD012969 UPF0211 RIKEN CDNA ENRICHED MALE FULL-LENGTH LIBRARY ZBTB8OS ADULT C43H8.1 8 131 7.0E-16 T 13-10-2018 IPR023572 Archease domain Reactome: R-HSA-6784531 TOPB45_1541 92f462fae28f284f5663d6c09b1a9588 144 SUPERFAMILY SSF69819 2 144 4.84E-30 T 13-10-2018 IPR036820 Archease domain superfamily Reactome: R-HSA-6784531 TOPB45_1541 92f462fae28f284f5663d6c09b1a9588 144 Gene3D G3DSA:3.55.10.10 1 144 8.3E-33 T 13-10-2018 IPR036820 Archease domain superfamily Reactome: R-HSA-6784531 TOPB45_1541 92f462fae28f284f5663d6c09b1a9588 144 Pfam PF01951 Archease protein family (MTH1598/TM1083) 4 144 1.3E-28 T 13-10-2018 IPR023572 Archease domain Reactome: R-HSA-6784531 TOPB45_0642 83a3ae29f22acb30c784ca302c2e2150 198 Gene3D G3DSA:1.10.357.10 57 196 2.7E-21 T 13-10-2018 TOPB45_0642 83a3ae29f22acb30c784ca302c2e2150 198 SUPERFAMILY SSF48498 79 193 3.04E-14 T 13-10-2018 IPR036271 Tetracyclin repressor-like, C-terminal domain superfamily TOPB45_0642 83a3ae29f22acb30c784ca302c2e2150 198 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 9 22 8.8E-11 T 13-10-2018 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TOPB45_0642 83a3ae29f22acb30c784ca302c2e2150 198 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 30 53 8.8E-11 T 13-10-2018 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TOPB45_0642 83a3ae29f22acb30c784ca302c2e2150 198 Pfam PF00440 Bacterial regulatory proteins, tetR family 9 55 9.9E-18 T 13-10-2018 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TOPB45_0642 83a3ae29f22acb30c784ca302c2e2150 198 SUPERFAMILY SSF46689 2 59 2.24E-16 T 13-10-2018 IPR009057 Homeobox-like domain superfamily GO:0003677 TOPB45_0642 83a3ae29f22acb30c784ca302c2e2150 198 Gene3D G3DSA:1.10.10.60 1 55 6.1E-18 T 13-10-2018 TOPB45_0834 adefb03eceac24d9d03b0e81b744be0d 433 SUPERFAMILY SSF81301 37 172 1.07E-23 T 13-10-2018 TOPB45_0834 adefb03eceac24d9d03b0e81b744be0d 433 Pfam PF01743 Poly A polymerase head domain 39 175 6.3E-22 T 13-10-2018 IPR002646 Poly A polymerase, head domain GO:0003723|GO:0006396|GO:0016779 Reactome: R-HSA-6784531|Reactome: R-HSA-6785470 TOPB45_0834 adefb03eceac24d9d03b0e81b744be0d 433 Gene3D G3DSA:3.30.460.10 5 171 2.9E-32 T 13-10-2018 TOPB45_0834 adefb03eceac24d9d03b0e81b744be0d 433 SUPERFAMILY SSF81891 181 429 3.4E-26 T 13-10-2018 TOPB45_0834 adefb03eceac24d9d03b0e81b744be0d 433 Gene3D G3DSA:1.10.3090.10 172 426 1.2E-39 T 13-10-2018 TOPB45_0515 3ad0fc0fe91e9138db6c12b42f7d2ffe 110 Pfam PF11146 Protein of unknown function (DUF2905) 44 107 7.9E-25 T 13-10-2018 IPR021320 Protein of unknown function DUF2905 TOPB45_0823 9020434d2a8b6f35226a88ac95160db6 336 SUPERFAMILY SSF53067 100 303 1.07E-47 T 13-10-2018 TOPB45_0823 9020434d2a8b6f35226a88ac95160db6 336 Hamap MF_01445 tRNA N6-adenosine threonylcarbamoyltransferase [tsaD]. 1 327 59.402 T 13-10-2018 IPR022450 tRNA N6-adenosine threonylcarbamoyltransferase, TsaD GO:0002949|GO:0004222 TOPB45_0823 9020434d2a8b6f35226a88ac95160db6 336 Pfam PF00814 Glycoprotease family 23 302 7.2E-95 T 13-10-2018 IPR000905 Gcp-like domain TOPB45_0823 9020434d2a8b6f35226a88ac95160db6 336 PRINTS PR00789 O-sialoglycoprotein endopeptidase (M22) metallo-protease family signature 3 16 1.1E-44 T 13-10-2018 IPR017861 Kae1/TsaD family TOPB45_0823 9020434d2a8b6f35226a88ac95160db6 336 PRINTS PR00789 O-sialoglycoprotein endopeptidase (M22) metallo-protease family signature 152 173 1.1E-44 T 13-10-2018 IPR017861 Kae1/TsaD family TOPB45_0823 9020434d2a8b6f35226a88ac95160db6 336 PRINTS PR00789 O-sialoglycoprotein endopeptidase (M22) metallo-protease family signature 75 95 1.1E-44 T 13-10-2018 IPR017861 Kae1/TsaD family TOPB45_0823 9020434d2a8b6f35226a88ac95160db6 336 PRINTS PR00789 O-sialoglycoprotein endopeptidase (M22) metallo-protease family signature 129 141 1.1E-44 T 13-10-2018 IPR017861 Kae1/TsaD family TOPB45_0823 9020434d2a8b6f35226a88ac95160db6 336 PRINTS PR00789 O-sialoglycoprotein endopeptidase (M22) metallo-protease family signature 96 115 1.1E-44 T 13-10-2018 IPR017861 Kae1/TsaD family TOPB45_0823 9020434d2a8b6f35226a88ac95160db6 336 PRINTS PR00789 O-sialoglycoprotein endopeptidase (M22) metallo-protease family signature 259 268 1.1E-44 T 13-10-2018 IPR017861 Kae1/TsaD family TOPB45_0823 9020434d2a8b6f35226a88ac95160db6 336 TIGRFAM TIGR03723 T6A_TsaD_YgjD: tRNA threonylcarbamoyl adenosine modification protein TsaD 3 309 3.8E-126 T 13-10-2018 IPR022450 tRNA N6-adenosine threonylcarbamoyltransferase, TsaD GO:0002949|GO:0004222 TOPB45_0823 9020434d2a8b6f35226a88ac95160db6 336 TIGRFAM TIGR00329 gcp_kae1: metallohydrolase, glycoprotease/Kae1 family 3 302 2.2E-105 T 13-10-2018 IPR017861 Kae1/TsaD family TOPB45_0823 9020434d2a8b6f35226a88ac95160db6 336 SUPERFAMILY SSF53067 1 121 1.12E-28 T 13-10-2018 TOPB45_0823 9020434d2a8b6f35226a88ac95160db6 336 Gene3D G3DSA:3.30.420.40 3 311 4.3E-122 T 13-10-2018 TOPB45_0823 9020434d2a8b6f35226a88ac95160db6 336 ProSitePatterns PS01016 Glycoprotease family signature. 95 115 - T 13-10-2018 IPR017860 Peptidase M22, conserved site Reactome: R-HSA-6782315 TOPB45_0823 9020434d2a8b6f35226a88ac95160db6 336 Gene3D G3DSA:3.30.420.40 127 289 4.3E-122 T 13-10-2018 TOPB45_0129 baf4a911c7aebd7129b8f32b96cdef3a 341 Gene3D G3DSA:3.40.1190.20 6 321 6.4E-99 T 13-10-2018 IPR029056 Ribokinase-like TOPB45_0129 baf4a911c7aebd7129b8f32b96cdef3a 341 Pfam PF00294 pfkB family carbohydrate kinase 17 313 5.1E-38 T 13-10-2018 IPR011611 Carbohydrate kinase PfkB TOPB45_0129 baf4a911c7aebd7129b8f32b96cdef3a 341 SUPERFAMILY SSF53613 16 324 2.53E-52 T 13-10-2018 IPR029056 Ribokinase-like TOPB45_0129 baf4a911c7aebd7129b8f32b96cdef3a 341 TIGRFAM TIGR02198 rfaE_dom_I: bifunctional protein RfaE, domain I 11 324 3.5E-107 T 13-10-2018 IPR011913 RfaE bifunctional protein, domain I GO:0005975|GO:0016773|GO:0016779 KEGG: 00540+2.7.7.70+2.7.1.167 TOPB45_1410 376f5c323229fe1f39b5e79aa8ac9ff3 465 Pfam PF00753 Metallo-beta-lactamase superfamily 14 78 6.7E-12 T 13-10-2018 IPR001279 Metallo-beta-lactamase TOPB45_1410 376f5c323229fe1f39b5e79aa8ac9ff3 465 SMART SM00849 15 233 4.0E-11 T 13-10-2018 IPR001279 Metallo-beta-lactamase TOPB45_1410 376f5c323229fe1f39b5e79aa8ac9ff3 465 Gene3D G3DSA:3.60.15.10 8 436 1.9E-145 T 13-10-2018 IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like TOPB45_1410 376f5c323229fe1f39b5e79aa8ac9ff3 465 Pfam PF07521 Zn-dependent metallo-hydrolase RNA specificity domain 391 447 2.8E-16 T 13-10-2018 IPR011108 Zn-dependent metallo-hydrolase, RNA specificity domain TOPB45_1410 376f5c323229fe1f39b5e79aa8ac9ff3 465 Gene3D G3DSA:3.40.50.10890 221 403 1.9E-145 T 13-10-2018 TOPB45_1410 376f5c323229fe1f39b5e79aa8ac9ff3 465 Pfam PF10996 Beta-Casp domain 253 377 2.4E-24 T 13-10-2018 IPR022712 Beta-Casp domain TOPB45_1410 376f5c323229fe1f39b5e79aa8ac9ff3 465 SMART SM01027 253 377 2.3E-56 T 13-10-2018 IPR022712 Beta-Casp domain TOPB45_1410 376f5c323229fe1f39b5e79aa8ac9ff3 465 SUPERFAMILY SSF56281 2 464 1.4E-130 T 13-10-2018 IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like TOPB45_1285 6efc064a035c292633be502734f0ec9f 638 Gene3D G3DSA:3.40.50.300 2 170 2.2E-54 T 13-10-2018 TOPB45_1285 6efc064a035c292633be502734f0ec9f 638 SUPERFAMILY SSF46785 582 636 2.04E-9 T 13-10-2018 IPR036390 Winged helix DNA-binding domain superfamily TOPB45_1285 6efc064a035c292633be502734f0ec9f 638 Pfam PF00009 Elongation factor Tu GTP binding domain 4 167 5.9E-37 T 13-10-2018 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TOPB45_1285 6efc064a035c292633be502734f0ec9f 638 Gene3D G3DSA:2.40.30.10 177 267 4.3E-28 T 13-10-2018 TOPB45_1285 6efc064a035c292633be502734f0ec9f 638 SUPERFAMILY SSF46785 440 508 1.14E-9 T 13-10-2018 IPR036390 Winged helix DNA-binding domain superfamily TOPB45_1285 6efc064a035c292633be502734f0ec9f 638 Pfam PF09107 Elongation factor SelB, winged helix 587 634 9.7E-18 T 13-10-2018 IPR015191 Translation elongation factor SelB, winged helix, type 3 GO:0001514|GO:0003723|GO:0003746|GO:0005525|GO:0005737 TOPB45_1285 6efc064a035c292633be502734f0ec9f 638 PRINTS PR00315 GTP-binding elongation factor signature 5 18 6.4E-7 T 13-10-2018 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TOPB45_1285 6efc064a035c292633be502734f0ec9f 638 PRINTS PR00315 GTP-binding elongation factor signature 73 84 6.4E-7 T 13-10-2018 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TOPB45_1285 6efc064a035c292633be502734f0ec9f 638 PRINTS PR00315 GTP-binding elongation factor signature 57 67 6.4E-7 T 13-10-2018 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TOPB45_1285 6efc064a035c292633be502734f0ec9f 638 PRINTS PR00315 GTP-binding elongation factor signature 110 119 6.4E-7 T 13-10-2018 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TOPB45_1285 6efc064a035c292633be502734f0ec9f 638 Pfam PF09106 Elongation factor SelB, winged helix 448 502 6.2E-11 T 13-10-2018 IPR015190 Translation elongation factor SelB, winged helix, type 2 GO:0001514|GO:0003723|GO:0003746|GO:0005525|GO:0005737 TOPB45_1285 6efc064a035c292633be502734f0ec9f 638 SUPERFAMILY SSF50465 266 363 1.19E-18 T 13-10-2018 IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal TOPB45_1285 6efc064a035c292633be502734f0ec9f 638 SUPERFAMILY SSF50447 175 264 1.48E-23 T 13-10-2018 IPR009000 Translation protein, beta-barrel domain superfamily TOPB45_1285 6efc064a035c292633be502734f0ec9f 638 SUPERFAMILY SSF52540 3 195 4.53E-50 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1285 6efc064a035c292633be502734f0ec9f 638 ProSitePatterns PS00301 Translational (tr)-type guanine nucleotide-binding (G) domain signature. 29 44 - T 13-10-2018 IPR031157 Tr-type G domain, conserved site TOPB45_1285 6efc064a035c292633be502734f0ec9f 638 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 2 164 1.3E-16 T 13-10-2018 IPR005225 Small GTP-binding protein domain GO:0005525 TOPB45_1285 6efc064a035c292633be502734f0ec9f 638 Gene3D G3DSA:1.10.10.10 574 635 2.1E-17 T 13-10-2018 IPR036388 Winged helix-like DNA-binding domain superfamily TOPB45_1285 6efc064a035c292633be502734f0ec9f 638 TIGRFAM TIGR00475 selB: selenocysteine-specific translation elongation factor 4 635 2.9E-118 T 13-10-2018 IPR004535 Translation elongation factor, selenocysteine-specific GO:0001514|GO:0003723|GO:0003746|GO:0005525|GO:0005737 TOPB45_1285 6efc064a035c292633be502734f0ec9f 638 Gene3D G3DSA:1.10.10.2770 442 573 1.6E-25 T 13-10-2018 TOPB45_1285 6efc064a035c292633be502734f0ec9f 638 Gene3D G3DSA:2.40.30.10 277 368 6.3E-8 T 13-10-2018 TOPB45_0393 5bfcdedd333c7f45dbcb3ea97be171aa 796 Gene3D G3DSA:3.40.50.11600 319 448 4.3E-49 T 13-10-2018 TOPB45_0393 5bfcdedd333c7f45dbcb3ea97be171aa 796 Gene3D G3DSA:3.20.20.20 501 762 1.5E-68 T 13-10-2018 IPR011005 Dihydropteroate synthase-like GO:0044237 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 TOPB45_0393 5bfcdedd333c7f45dbcb3ea97be171aa 796 Gene3D G3DSA:3.20.20.20 1 318 2.2E-92 T 13-10-2018 IPR011005 Dihydropteroate synthase-like GO:0044237 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 TOPB45_0393 5bfcdedd333c7f45dbcb3ea97be171aa 796 Pfam PF00809 Pterin binding enzyme 509 709 2.7E-23 T 13-10-2018 IPR000489 Pterin-binding domain GO:0042558 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 TOPB45_0393 5bfcdedd333c7f45dbcb3ea97be171aa 796 SUPERFAMILY SSF51717 135 300 6.93E-8 T 13-10-2018 IPR011005 Dihydropteroate synthase-like GO:0044237 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 TOPB45_0393 5bfcdedd333c7f45dbcb3ea97be171aa 796 SUPERFAMILY SSF51717 504 754 7.98E-61 T 13-10-2018 IPR011005 Dihydropteroate synthase-like GO:0044237 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 TOPB45_0393 5bfcdedd333c7f45dbcb3ea97be171aa 796 Pfam PF04060 Putative Fe-S cluster 12 44 5.0E-15 T 13-10-2018 IPR007202 4Fe-4S domain GO:0051536 TOPB45_0393 5bfcdedd333c7f45dbcb3ea97be171aa 796 Pfam PF03599 CO dehydrogenase/acetyl-CoA synthase delta subunit 63 442 1.6E-81 T 13-10-2018 IPR016041 CO dehydrogenase/acetyl-CoA synthase delta subunit, TIM barrel TOPB45_0374 6d88152a6691feaccbd5830569a99f7f 217 PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature 81 97 1.2E-5 T 13-10-2018 TOPB45_0374 6d88152a6691feaccbd5830569a99f7f 217 PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature 51 65 1.2E-5 T 13-10-2018 TOPB45_0374 6d88152a6691feaccbd5830569a99f7f 217 Gene3D G3DSA:3.40.50.880 1 190 9.1E-54 T 13-10-2018 IPR029062 Class I glutamine amidotransferase-like TOPB45_0374 6d88152a6691feaccbd5830569a99f7f 217 PRINTS PR00096 Glutamine amidotransferase superfamily signature 81 92 4.0E-12 T 13-10-2018 TOPB45_0374 6d88152a6691feaccbd5830569a99f7f 217 PRINTS PR00096 Glutamine amidotransferase superfamily signature 171 184 4.0E-12 T 13-10-2018 TOPB45_0374 6d88152a6691feaccbd5830569a99f7f 217 PRINTS PR00096 Glutamine amidotransferase superfamily signature 54 63 4.0E-12 T 13-10-2018 TOPB45_0374 6d88152a6691feaccbd5830569a99f7f 217 Pfam PF00117 Glutamine amidotransferase class-I 5 184 1.7E-46 T 13-10-2018 IPR017926 Glutamine amidotransferase TOPB45_0374 6d88152a6691feaccbd5830569a99f7f 217 TIGRFAM TIGR00566 trpG_papA: glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase 4 182 1.7E-67 T 13-10-2018 IPR006221 Anthranilate synthase/para-aminobenzoate synthase like domain KEGG: 00400+4.1.3.27|KEGG: 00405+4.1.3.27|MetaCyc: PWY-5958|MetaCyc: PWY-6660|MetaCyc: PWY-6661 TOPB45_0374 6d88152a6691feaccbd5830569a99f7f 217 SUPERFAMILY SSF52317 1 187 4.58E-49 T 13-10-2018 IPR029062 Class I glutamine amidotransferase-like TOPB45_0374 6d88152a6691feaccbd5830569a99f7f 217 PRINTS PR00097 Anthranilate synthase component II signature 81 92 2.8E-33 T 13-10-2018 TOPB45_0374 6d88152a6691feaccbd5830569a99f7f 217 PRINTS PR00097 Anthranilate synthase component II signature 126 138 2.8E-33 T 13-10-2018 TOPB45_0374 6d88152a6691feaccbd5830569a99f7f 217 PRINTS PR00097 Anthranilate synthase component II signature 54 63 2.8E-33 T 13-10-2018 TOPB45_0374 6d88152a6691feaccbd5830569a99f7f 217 PRINTS PR00097 Anthranilate synthase component II signature 4 18 2.8E-33 T 13-10-2018 TOPB45_0374 6d88152a6691feaccbd5830569a99f7f 217 PRINTS PR00097 Anthranilate synthase component II signature 171 184 2.8E-33 T 13-10-2018 TOPB45_0374 6d88152a6691feaccbd5830569a99f7f 217 PRINTS PR00097 Anthranilate synthase component II signature 106 114 2.8E-33 T 13-10-2018 TOPB45_0008 860a3ce24c23d3b427c550728a827d46 292 TIGRFAM TIGR02532 IV_pilin_GFxxxE: prepilin-type N-terminal cleavage/methylation domain 8 31 4.6E-6 T 13-10-2018 IPR012902 Prokaryotic N-terminal methylation site TOPB45_0008 860a3ce24c23d3b427c550728a827d46 292 Pfam PF07963 Prokaryotic N-terminal methylation motif 6 31 5.1E-8 T 13-10-2018 IPR012902 Prokaryotic N-terminal methylation site TOPB45_0175 870efe3fce64385bc86e82f6a3b32673 412 Gene3D G3DSA:3.50.50.60 4 107 2.1E-12 T 13-10-2018 IPR036188 FAD/NAD(P)-binding domain superfamily TOPB45_0175 870efe3fce64385bc86e82f6a3b32673 412 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 104 115 - T 13-10-2018 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site TOPB45_0175 870efe3fce64385bc86e82f6a3b32673 412 SUPERFAMILY SSF51905 2 411 4.53E-31 T 13-10-2018 IPR036188 FAD/NAD(P)-binding domain superfamily TOPB45_0175 870efe3fce64385bc86e82f6a3b32673 412 Pfam PF12831 FAD dependent oxidoreductase 5 41 3.8E-10 T 13-10-2018 IPR039649 Digeranylgeranylglycerophospholipid reductase, N-terminal TOPB45_0175 870efe3fce64385bc86e82f6a3b32673 412 Gene3D G3DSA:3.50.50.60 265 408 3.5E-5 T 13-10-2018 IPR036188 FAD/NAD(P)-binding domain superfamily TOPB45_0175 870efe3fce64385bc86e82f6a3b32673 412 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 5 24 1.6E-6 T 13-10-2018 TOPB45_0175 870efe3fce64385bc86e82f6a3b32673 412 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 344 360 1.6E-6 T 13-10-2018 TOPB45_0988 16d03ac0d899989fd60174e9a087e0a8 284 Gene3D G3DSA:1.10.3210.10 1 272 5.6E-64 T 13-10-2018 TOPB45_0988 16d03ac0d899989fd60174e9a087e0a8 284 Pfam PF08668 HDOD domain 16 214 1.2E-48 T 13-10-2018 IPR013976 Metal-dependent hydrolase HDOD TOPB45_0988 16d03ac0d899989fd60174e9a087e0a8 284 SUPERFAMILY SSF109604 4 269 6.6E-63 T 13-10-2018 TOPB45_0988 16d03ac0d899989fd60174e9a087e0a8 284 TIGRFAM TIGR00277 HDIG: HDIG domain 111 214 5.2E-8 T 13-10-2018 IPR006675 HDIG domain TOPB45_0988 16d03ac0d899989fd60174e9a087e0a8 284 SMART SM00471 107 245 1.0E-6 T 13-10-2018 IPR003607 HD/PDEase domain TOPB45_1544 dfccb51f7ee5e18223fda78c370d2db1 193 Gene3D G3DSA:3.40.50.10420 2 189 9.3E-54 T 13-10-2018 IPR024185 5-formyltetrahydrofolate cyclo-ligase-like domain superfamily TOPB45_1544 dfccb51f7ee5e18223fda78c370d2db1 193 PIRSF PIRSF006806 3 185 1.6E-41 T 13-10-2018 IPR002698 5-formyltetrahydrofolate cyclo-ligase TOPB45_1544 dfccb51f7ee5e18223fda78c370d2db1 193 Pfam PF01812 5-formyltetrahydrofolate cyclo-ligase family 6 182 8.4E-38 T 13-10-2018 IPR002698 5-formyltetrahydrofolate cyclo-ligase TOPB45_1544 dfccb51f7ee5e18223fda78c370d2db1 193 SUPERFAMILY SSF100950 5 186 5.72E-48 T 13-10-2018 IPR037171 NagB/RpiA transferase-like TOPB45_1544 dfccb51f7ee5e18223fda78c370d2db1 193 TIGRFAM TIGR02727 MTHFS_bact: 5-formyltetrahydrofolate cyclo-ligase 6 182 1.1E-45 T 13-10-2018 IPR002698 5-formyltetrahydrofolate cyclo-ligase TOPB45_0470 8d4fd429723b2214ca80bba342eca958 316 Pfam PF02237 Biotin protein ligase C terminal domain 265 311 5.4E-10 T 13-10-2018 IPR003142 Biotin protein ligase, C-terminal GO:0006464 KEGG: 00780+6.3.4.15|Reactome: R-HSA-196780|Reactome: R-HSA-3371599 TOPB45_0470 8d4fd429723b2214ca80bba342eca958 316 Hamap MF_00978 Bifunctional ligase/repressor BirA [birA]. 10 312 31.032 T 13-10-2018 IPR030855 Bifunctional ligase/repressor BirA GO:0004077|GO:0006355 KEGG: 00780+6.3.4.15 TOPB45_0470 8d4fd429723b2214ca80bba342eca958 316 SUPERFAMILY SSF55681 74 250 1.74E-47 T 13-10-2018 TOPB45_0470 8d4fd429723b2214ca80bba342eca958 316 SUPERFAMILY SSF46785 6 59 3.35E-11 T 13-10-2018 IPR036390 Winged helix DNA-binding domain superfamily TOPB45_0470 8d4fd429723b2214ca80bba342eca958 316 Pfam PF03099 Biotin/lipoate A/B protein ligase family 85 208 7.6E-18 T 13-10-2018 IPR004143 Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL), catalytic domain GO:0006464 KEGG: 00785+2.3.1.181|MetaCyc: PWY-6987|MetaCyc: PWY-7382 TOPB45_0470 8d4fd429723b2214ca80bba342eca958 316 Gene3D G3DSA:1.10.10.10 1 62 9.4E-19 T 13-10-2018 IPR036388 Winged helix-like DNA-binding domain superfamily TOPB45_0470 8d4fd429723b2214ca80bba342eca958 316 SUPERFAMILY SSF50037 267 311 2.75E-6 T 13-10-2018 IPR008988 Transcriptional repressor, C-terminal TOPB45_0470 8d4fd429723b2214ca80bba342eca958 316 TIGRFAM TIGR00121 birA_ligase: biotin--[acetyl-CoA-carboxylase] ligase 79 311 4.7E-59 T 13-10-2018 IPR004408 Biotin--acetyl-CoA-carboxylase ligase GO:0004077|GO:0006464 KEGG: 00780+6.3.4.15|Reactome: R-HSA-196780|Reactome: R-HSA-3371599 TOPB45_0470 8d4fd429723b2214ca80bba342eca958 316 Gene3D G3DSA:2.30.30.100 264 313 2.3E-16 T 13-10-2018 TOPB45_0470 8d4fd429723b2214ca80bba342eca958 316 Pfam PF08279 HTH domain 8 58 1.8E-15 T 13-10-2018 IPR013196 Helix-turn-helix, type 11 TOPB45_0470 8d4fd429723b2214ca80bba342eca958 316 Gene3D G3DSA:3.30.930.10 77 263 9.3E-55 T 13-10-2018 TOPB45_1634 78ee7c7a4269cde158c0f8740f913859 314 Pfam PF00005 ABC transporter 22 179 3.0E-26 T 13-10-2018 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TOPB45_1634 78ee7c7a4269cde158c0f8740f913859 314 TIGRFAM TIGR01727 oligo_HPY: oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain 229 311 3.8E-22 T 13-10-2018 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 TOPB45_1634 78ee7c7a4269cde158c0f8740f913859 314 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 231 288 4.7E-16 T 13-10-2018 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 TOPB45_1634 78ee7c7a4269cde158c0f8740f913859 314 Gene3D G3DSA:3.40.50.300 2 314 1.9E-87 T 13-10-2018 TOPB45_1634 78ee7c7a4269cde158c0f8740f913859 314 SMART SM00382 30 229 8.2E-13 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_1634 78ee7c7a4269cde158c0f8740f913859 314 SUPERFAMILY SSF52540 30 308 1.77E-63 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1565 50e1bde7e3143fbcb124f9dee1179246 967 SUPERFAMILY SSF64518 112 964 8.76E-20 T 13-10-2018 TOPB45_1565 50e1bde7e3143fbcb124f9dee1179246 967 Pfam PF06429 Flagellar basal body rod FlgEFG protein C-terminal 918 964 1.2E-10 T 13-10-2018 IPR010930 Flagellar basal-body/hook protein, C-terminal domain TOPB45_1565 50e1bde7e3143fbcb124f9dee1179246 967 PRINTS PR01005 Flagellar hook-associated protein signature 219 237 2.7E-9 T 13-10-2018 IPR002371 Flagellar hook-associated protein 1 GO:0005198|GO:0009424|GO:0044780 TOPB45_1565 50e1bde7e3143fbcb124f9dee1179246 967 PRINTS PR01005 Flagellar hook-associated protein signature 14 37 2.7E-9 T 13-10-2018 IPR002371 Flagellar hook-associated protein 1 GO:0005198|GO:0009424|GO:0044780 TOPB45_1565 50e1bde7e3143fbcb124f9dee1179246 967 PRINTS PR01005 Flagellar hook-associated protein signature 161 185 2.7E-9 T 13-10-2018 IPR002371 Flagellar hook-associated protein 1 GO:0005198|GO:0009424|GO:0044780 TOPB45_1565 50e1bde7e3143fbcb124f9dee1179246 967 PRINTS PR01005 Flagellar hook-associated protein signature 52 74 2.7E-9 T 13-10-2018 IPR002371 Flagellar hook-associated protein 1 GO:0005198|GO:0009424|GO:0044780 TOPB45_1565 50e1bde7e3143fbcb124f9dee1179246 967 TIGRFAM TIGR02492 flgK_ends: flagellar hook-associated protein FlgK 7 290 1.9E-65 T 13-10-2018 IPR002371 Flagellar hook-associated protein 1 GO:0005198|GO:0009424|GO:0044780 TOPB45_0609 66d00c3985019c99af8d6540a834f426 299 Pfam PF01370 NAD dependent epimerase/dehydratase family 4 220 2.3E-23 T 13-10-2018 IPR001509 NAD-dependent epimerase/dehydratase GO:0003824|GO:0050662 TOPB45_0609 66d00c3985019c99af8d6540a834f426 299 Pfam PF08338 Domain of unknown function (DUF1731) 248 294 3.8E-13 T 13-10-2018 IPR013549 Domain of unknown function DUF1731 TOPB45_0609 66d00c3985019c99af8d6540a834f426 299 SUPERFAMILY SSF51735 2 247 7.39E-49 T 13-10-2018 IPR036291 NAD(P)-binding domain superfamily TOPB45_0609 66d00c3985019c99af8d6540a834f426 299 Gene3D G3DSA:3.40.50.720 1 285 3.2E-76 T 13-10-2018 TOPB45_0609 66d00c3985019c99af8d6540a834f426 299 TIGRFAM TIGR01777 yfcH: TIGR01777 family protein 4 291 2.2E-94 T 13-10-2018 IPR010099 Epimerase family protein SDR39U1 TOPB45_0469 edaf3b69c490e56c03fcb68909da815c 137 ProDom PD085044 MEMBRANE AF1562 TRANSMEMBRANE 8 137 3.0E-24 T 13-10-2018 IPR020327 Uncharacterised protein family AF1562 TOPB45_1016 1b87bc9c2951fdeb98153910f5c482e3 198 Gene3D G3DSA:1.10.8.10 1 55 1.3E-25 T 13-10-2018 TOPB45_1016 1b87bc9c2951fdeb98153910f5c482e3 198 Hamap MF_00050 Elongation factor Ts [tsf]. 1 198 47.191 T 13-10-2018 IPR001816 Translation elongation factor EFTs/EF1B GO:0003746|GO:0005622|GO:0006414 Reactome: R-HSA-5389840 TOPB45_1016 1b87bc9c2951fdeb98153910f5c482e3 198 SUPERFAMILY SSF54713 58 198 5.49E-54 T 13-10-2018 IPR036402 Elongation factor Ts, dimerisation domain superfamily Reactome: R-HSA-5389840 TOPB45_1016 1b87bc9c2951fdeb98153910f5c482e3 198 ProSitePatterns PS01127 Elongation factor Ts signature 2. 77 87 - T 13-10-2018 IPR018101 Translation elongation factor Ts, conserved site GO:0003746|GO:0005622|GO:0006414 Reactome: R-HSA-5389840 TOPB45_1016 1b87bc9c2951fdeb98153910f5c482e3 198 Gene3D G3DSA:1.10.286.20 112 156 7.1E-60 T 13-10-2018 TOPB45_1016 1b87bc9c2951fdeb98153910f5c482e3 198 TIGRFAM TIGR00116 tsf: translation elongation factor Ts 1 98 2.4E-37 T 13-10-2018 IPR001816 Translation elongation factor EFTs/EF1B GO:0003746|GO:0005622|GO:0006414 Reactome: R-HSA-5389840 TOPB45_1016 1b87bc9c2951fdeb98153910f5c482e3 198 SUPERFAMILY SSF46934 3 55 3.18E-18 T 13-10-2018 IPR009060 UBA-like superfamily GO:0005515 TOPB45_1016 1b87bc9c2951fdeb98153910f5c482e3 198 Pfam PF00889 Elongation factor TS 40 198 2.4E-43 T 13-10-2018 IPR014039 Translation elongation factor EFTs/EF1B, dimerisation GO:0003746|GO:0006414 Reactome: R-HSA-5389840 TOPB45_1016 1b87bc9c2951fdeb98153910f5c482e3 198 Gene3D G3DSA:3.30.479.20 60 197 7.1E-60 T 13-10-2018 IPR036402 Elongation factor Ts, dimerisation domain superfamily Reactome: R-HSA-5389840 TOPB45_1442 ba01d96526e36d532ef086ac93f7fde6 93 Gene3D G3DSA:1.20.58.110 1 86 1.3E-26 T 13-10-2018 IPR036510 Ribosomal protein S20 superfamily GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_1442 ba01d96526e36d532ef086ac93f7fde6 93 SUPERFAMILY SSF46992 4 86 2.49E-27 T 13-10-2018 IPR036510 Ribosomal protein S20 superfamily GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_1442 ba01d96526e36d532ef086ac93f7fde6 93 ProDom PD004231 RIBOSOMAL S20 30S RRNA-BINDING RNA-BINDING RIBONUCLEOPROTEIN S20P SUBUNIT CHLOROPLAST DIRECT 14 85 9.0E-14 T 13-10-2018 IPR002583 Ribosomal protein S20 GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_1442 ba01d96526e36d532ef086ac93f7fde6 93 TIGRFAM TIGR00029 S20: ribosomal protein bS20 3 85 3.9E-20 T 13-10-2018 IPR002583 Ribosomal protein S20 GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_1442 ba01d96526e36d532ef086ac93f7fde6 93 Hamap MF_00500 30S ribosomal protein S20 [rpsT]. 1 85 14.916 T 13-10-2018 IPR002583 Ribosomal protein S20 GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_1442 ba01d96526e36d532ef086ac93f7fde6 93 Pfam PF01649 Ribosomal protein S20 2 84 2.9E-27 T 13-10-2018 IPR002583 Ribosomal protein S20 GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0477 376e28e41292b4f1f5513508104ef4d9 264 Hamap MF_00056 2-dehydro-3-deoxyphosphooctonate aldolase [kdsA]. 1 261 48.855 T 13-10-2018 IPR006269 3-deoxy-8-phosphooctulonate synthase GO:0005737|GO:0008676 KEGG: 00540+2.5.1.55|MetaCyc: PWY-1269|MetaCyc: PWY-7674 TOPB45_0477 376e28e41292b4f1f5513508104ef4d9 264 SUPERFAMILY SSF51569 3 260 7.97E-98 T 13-10-2018 TOPB45_0477 376e28e41292b4f1f5513508104ef4d9 264 Pfam PF00793 DAHP synthetase I family 3 258 5.3E-68 T 13-10-2018 IPR006218 DAHP synthetase I/KDSA GO:0009058 KEGG: 00540+2.5.1.55|MetaCyc: PWY-1269|MetaCyc: PWY-7674 TOPB45_0477 376e28e41292b4f1f5513508104ef4d9 264 TIGRFAM TIGR01362 KDO8P_synth: 3-deoxy-8-phosphooctulonate synthase 3 259 2.7E-116 T 13-10-2018 IPR006269 3-deoxy-8-phosphooctulonate synthase GO:0005737|GO:0008676 KEGG: 00540+2.5.1.55|MetaCyc: PWY-1269|MetaCyc: PWY-7674 TOPB45_0477 376e28e41292b4f1f5513508104ef4d9 264 Gene3D G3DSA:3.20.20.70 1 262 1.6E-99 T 13-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 TOPB45_0935 07a7a363148eeb516dc7534030e535e4 154 Gene3D G3DSA:2.40.330.20 1 144 1.5E-42 T 13-10-2018 IPR038619 MraZ superfamily TOPB45_0935 07a7a363148eeb516dc7534030e535e4 154 TIGRFAM TIGR00242 TIGR00242: division/cell wall cluster transcriptional repressor MraZ 1 139 1.7E-37 T 13-10-2018 IPR003444 Transcriptional regulator MraZ GO:0003700|GO:0006355 TOPB45_0935 07a7a363148eeb516dc7534030e535e4 154 ProDom PD006745 MRAZ YABB DIVISION CELL 3D-STRUCTURE UNCHARACTERIZED BCR SIMILAR PROTEIN 2 142 2.0E-31 T 13-10-2018 IPR003444 Transcriptional regulator MraZ GO:0003700|GO:0006355 TOPB45_0935 07a7a363148eeb516dc7534030e535e4 154 Pfam PF02381 MraZ protein, putative antitoxin-like 1 67 5.3E-13 T 13-10-2018 IPR020603 MraZ domain TOPB45_0935 07a7a363148eeb516dc7534030e535e4 154 Pfam PF02381 MraZ protein, putative antitoxin-like 76 137 4.8E-14 T 13-10-2018 IPR020603 MraZ domain TOPB45_0935 07a7a363148eeb516dc7534030e535e4 154 Hamap MF_01008 Transcriptional regulator MraZ [mraZ]. 1 154 43.698 T 13-10-2018 IPR003444 Transcriptional regulator MraZ GO:0003700|GO:0006355 TOPB45_0935 07a7a363148eeb516dc7534030e535e4 154 SUPERFAMILY SSF89447 1 138 7.15E-42 T 13-10-2018 IPR037914 SpoVT-AbrB domain superfamily TOPB45_0619 c577c05dbdf9e86f1289e708c84e4df2 866 Hamap MF_00036_B Alanine--tRNA ligase [alaS]. 1 866 167.827 T 13-10-2018 IPR023033 Alanine-tRNA ligase, eukaryota/bacteria GO:0004813 KEGG: 00970+6.1.1.7 TOPB45_0619 c577c05dbdf9e86f1289e708c84e4df2 866 Pfam PF02272 DHHA1 domain 727 861 7.5E-12 T 13-10-2018 IPR003156 DHHA1 domain GO:0003676 KEGG: 00970+6.1.1.7|Reactome: R-HSA-379716 TOPB45_0619 c577c05dbdf9e86f1289e708c84e4df2 866 Pfam PF01411 tRNA synthetases class II (A) 6 549 4.6E-210 T 13-10-2018 IPR018164 Alanyl-tRNA synthetase, class IIc, N-terminal GO:0000166|GO:0004813|GO:0005524|GO:0006419 KEGG: 00970+6.1.1.7 TOPB45_0619 c577c05dbdf9e86f1289e708c84e4df2 866 SUPERFAMILY SSF55186 545 705 2.88E-53 T 13-10-2018 IPR018163 Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily GO:0000166 TOPB45_0619 c577c05dbdf9e86f1289e708c84e4df2 866 Gene3D G3DSA:3.30.54.20 617 670 1.8E-54 T 13-10-2018 TOPB45_0619 c577c05dbdf9e86f1289e708c84e4df2 866 SUPERFAMILY SSF55681 4 245 2.49E-109 T 13-10-2018 TOPB45_0619 c577c05dbdf9e86f1289e708c84e4df2 866 PRINTS PR00980 Alanyl-tRNA synthetase signature 199 210 1.5E-30 T 13-10-2018 IPR002318 Alanine-tRNA ligase, class IIc GO:0000166|GO:0005737 KEGG: 00970+6.1.1.7 TOPB45_0619 c577c05dbdf9e86f1289e708c84e4df2 866 PRINTS PR00980 Alanyl-tRNA synthetase signature 300 313 1.5E-30 T 13-10-2018 IPR002318 Alanine-tRNA ligase, class IIc GO:0000166|GO:0005737 KEGG: 00970+6.1.1.7 TOPB45_0619 c577c05dbdf9e86f1289e708c84e4df2 866 PRINTS PR00980 Alanyl-tRNA synthetase signature 74 85 1.5E-30 T 13-10-2018 IPR002318 Alanine-tRNA ligase, class IIc GO:0000166|GO:0005737 KEGG: 00970+6.1.1.7 TOPB45_0619 c577c05dbdf9e86f1289e708c84e4df2 866 PRINTS PR00980 Alanyl-tRNA synthetase signature 276 292 1.5E-30 T 13-10-2018 IPR002318 Alanine-tRNA ligase, class IIc GO:0000166|GO:0005737 KEGG: 00970+6.1.1.7 TOPB45_0619 c577c05dbdf9e86f1289e708c84e4df2 866 PRINTS PR00980 Alanyl-tRNA synthetase signature 226 239 1.5E-30 T 13-10-2018 IPR002318 Alanine-tRNA ligase, class IIc GO:0000166|GO:0005737 KEGG: 00970+6.1.1.7 TOPB45_0619 c577c05dbdf9e86f1289e708c84e4df2 866 SUPERFAMILY SSF50447 457 545 1.59E-15 T 13-10-2018 IPR009000 Translation protein, beta-barrel domain superfamily TOPB45_0619 c577c05dbdf9e86f1289e708c84e4df2 866 TIGRFAM TIGR00344 alaS: alanine--tRNA ligase 6 844 4.1E-296 T 13-10-2018 IPR002318 Alanine-tRNA ligase, class IIc GO:0000166|GO:0005737 KEGG: 00970+6.1.1.7 TOPB45_0619 c577c05dbdf9e86f1289e708c84e4df2 866 Pfam PF07973 Threonyl and Alanyl tRNA synthetase second additional domain 646 688 6.3E-19 T 13-10-2018 IPR012947 Threonyl/alanyl tRNA synthetase, SAD GO:0004812|GO:0005524|GO:0043039 TOPB45_0619 c577c05dbdf9e86f1289e708c84e4df2 866 Gene3D G3DSA:3.10.310.40 756 863 6.2E-18 T 13-10-2018 TOPB45_0619 c577c05dbdf9e86f1289e708c84e4df2 866 Gene3D G3DSA:3.30.930.10 2 242 2.5E-113 T 13-10-2018 TOPB45_0619 c577c05dbdf9e86f1289e708c84e4df2 866 Gene3D G3DSA:3.30.980.10 549 688 1.8E-54 T 13-10-2018 TOPB45_0619 c577c05dbdf9e86f1289e708c84e4df2 866 Gene3D G3DSA:2.40.30.130 462 546 3.8E-12 T 13-10-2018 TOPB45_0619 c577c05dbdf9e86f1289e708c84e4df2 866 SMART SM00863 646 689 1.6E-20 T 13-10-2018 IPR012947 Threonyl/alanyl tRNA synthetase, SAD GO:0004812|GO:0005524|GO:0043039 TOPB45_0619 c577c05dbdf9e86f1289e708c84e4df2 866 SUPERFAMILY SSF101353 246 463 7.85E-66 T 13-10-2018 IPR018162 Alanine-tRNA ligase, class IIc, anti-codon-binding domain superfamily GO:0000166|GO:0004813|GO:0005524|GO:0005737|GO:0006419 KEGG: 00970+6.1.1.7 TOPB45_0379 68106cd86ff94f336bb6cd64c823a2b0 369 SUPERFAMILY SSF53092 10 129 1.19E-21 T 13-10-2018 IPR029149 Creatinase/Aminopeptidase P/Spt16, N-terminal TOPB45_0379 68106cd86ff94f336bb6cd64c823a2b0 369 Pfam PF00557 Metallopeptidase family M24 138 351 3.0E-51 T 13-10-2018 IPR000994 Peptidase M24 TOPB45_0379 68106cd86ff94f336bb6cd64c823a2b0 369 SUPERFAMILY SSF55920 131 367 3.4E-59 T 13-10-2018 IPR036005 Creatinase/aminopeptidase-like TOPB45_0379 68106cd86ff94f336bb6cd64c823a2b0 369 Gene3D G3DSA:3.40.350.10 2 129 3.7E-28 T 13-10-2018 IPR029149 Creatinase/Aminopeptidase P/Spt16, N-terminal TOPB45_0379 68106cd86ff94f336bb6cd64c823a2b0 369 Pfam PF01321 Creatinase/Prolidase N-terminal domain 7 129 1.7E-19 T 13-10-2018 IPR000587 Creatinase, N-terminal GO:0016787 TOPB45_0379 68106cd86ff94f336bb6cd64c823a2b0 369 Gene3D G3DSA:3.90.230.10 130 365 1.3E-63 T 13-10-2018 TOPB45_1528 d302cae422826667eafb9f7a709ae38f 550 Pfam PF05746 DALR anticodon binding domain 430 550 8.2E-34 T 13-10-2018 IPR008909 DALR anticodon binding GO:0004814|GO:0005524|GO:0006420 TOPB45_1528 d302cae422826667eafb9f7a709ae38f 550 Hamap MF_00123 Arginine--tRNA ligase [argS]. 4 550 27.818 T 13-10-2018 IPR001278 Arginine-tRNA ligase GO:0004814|GO:0005524|GO:0006420 KEGG: 00970+6.1.1.19 TOPB45_1528 d302cae422826667eafb9f7a709ae38f 550 ProSitePatterns PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 127 136 - T 13-10-2018 IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site GO:0000166|GO:0004812|GO:0005524|GO:0006418 TOPB45_1528 d302cae422826667eafb9f7a709ae38f 550 Pfam PF03485 Arginyl tRNA synthetase N terminal domain 5 87 9.7E-19 T 13-10-2018 IPR005148 Arginyl tRNA synthetase N-terminal domain GO:0000166|GO:0004814|GO:0005524|GO:0005737|GO:0006420 KEGG: 00970+6.1.1.19|Reactome: R-HSA-2408517|Reactome: R-HSA-379716 TOPB45_1528 d302cae422826667eafb9f7a709ae38f 550 PRINTS PR01038 Arginyl-tRNA synthetase signature 156 169 9.4E-25 T 13-10-2018 IPR001278 Arginine-tRNA ligase GO:0004814|GO:0005524|GO:0006420 KEGG: 00970+6.1.1.19 TOPB45_1528 d302cae422826667eafb9f7a709ae38f 550 PRINTS PR01038 Arginyl-tRNA synthetase signature 298 319 9.4E-25 T 13-10-2018 IPR001278 Arginine-tRNA ligase GO:0004814|GO:0005524|GO:0006420 KEGG: 00970+6.1.1.19 TOPB45_1528 d302cae422826667eafb9f7a709ae38f 550 PRINTS PR01038 Arginyl-tRNA synthetase signature 132 148 9.4E-25 T 13-10-2018 IPR001278 Arginine-tRNA ligase GO:0004814|GO:0005524|GO:0006420 KEGG: 00970+6.1.1.19 TOPB45_1528 d302cae422826667eafb9f7a709ae38f 550 PRINTS PR01038 Arginyl-tRNA synthetase signature 117 132 9.4E-25 T 13-10-2018 IPR001278 Arginine-tRNA ligase GO:0004814|GO:0005524|GO:0006420 KEGG: 00970+6.1.1.19 TOPB45_1528 d302cae422826667eafb9f7a709ae38f 550 Gene3D G3DSA:3.30.1360.70 1 113 2.0E-24 T 13-10-2018 IPR036695 Arginyl tRNA synthetase N-terminal domain superfamily GO:0000166|GO:0004814|GO:0005524|GO:0005737|GO:0006420 KEGG: 00970+6.1.1.19 TOPB45_1528 d302cae422826667eafb9f7a709ae38f 550 Pfam PF00750 tRNA synthetases class I (R) 97 397 9.9E-32 T 13-10-2018 IPR035684 Arginyl-tRNA synthetase, catalytic core domain KEGG: 00970+6.1.1.19 TOPB45_1528 d302cae422826667eafb9f7a709ae38f 550 SUPERFAMILY SSF47323 425 550 1.96E-36 T 13-10-2018 IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 TOPB45_1528 d302cae422826667eafb9f7a709ae38f 550 SUPERFAMILY SSF55190 4 108 2.62E-19 T 13-10-2018 IPR036695 Arginyl tRNA synthetase N-terminal domain superfamily GO:0000166|GO:0004814|GO:0005524|GO:0005737|GO:0006420 KEGG: 00970+6.1.1.19 TOPB45_1528 d302cae422826667eafb9f7a709ae38f 550 SUPERFAMILY SSF52374 111 440 5.63E-96 T 13-10-2018 TOPB45_1528 d302cae422826667eafb9f7a709ae38f 550 SMART SM00836 430 550 7.2E-51 T 13-10-2018 IPR008909 DALR anticodon binding GO:0004814|GO:0005524|GO:0006420 TOPB45_1528 d302cae422826667eafb9f7a709ae38f 550 SMART SM01016 4 88 8.1E-23 T 13-10-2018 IPR005148 Arginyl tRNA synthetase N-terminal domain GO:0000166|GO:0004814|GO:0005524|GO:0005737|GO:0006420 KEGG: 00970+6.1.1.19|Reactome: R-HSA-2408517|Reactome: R-HSA-379716 TOPB45_1528 d302cae422826667eafb9f7a709ae38f 550 Gene3D G3DSA:3.40.50.620 117 424 7.0E-180 T 13-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TOPB45_1528 d302cae422826667eafb9f7a709ae38f 550 TIGRFAM TIGR00456 argS: arginine--tRNA ligase 2 550 5.5E-147 T 13-10-2018 IPR001278 Arginine-tRNA ligase GO:0004814|GO:0005524|GO:0006420 KEGG: 00970+6.1.1.19 TOPB45_1528 d302cae422826667eafb9f7a709ae38f 550 Gene3D G3DSA:1.10.730.10 425 550 7.0E-180 T 13-10-2018 TOPB45_1515 f5a6fdffab5d2451b5f8428e3fbf2342 580 Gene3D G3DSA:1.10.490.140 85 383 1.2E-28 T 13-10-2018 TOPB45_1515 f5a6fdffab5d2451b5f8428e3fbf2342 580 SUPERFAMILY SSF48452 419 562 2.53E-24 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_1515 f5a6fdffab5d2451b5f8428e3fbf2342 580 SMART SM00028 529 562 20.0 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_1515 f5a6fdffab5d2451b5f8428e3fbf2342 580 SMART SM00028 425 458 1.2E-4 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_1515 f5a6fdffab5d2451b5f8428e3fbf2342 580 SMART SM00028 495 528 7.3E-7 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_1515 f5a6fdffab5d2451b5f8428e3fbf2342 580 Gene3D G3DSA:1.25.40.10 461 575 5.0E-20 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_1515 f5a6fdffab5d2451b5f8428e3fbf2342 580 Gene3D G3DSA:3.30.160.660 217 337 1.2E-28 T 13-10-2018 TOPB45_1515 f5a6fdffab5d2451b5f8428e3fbf2342 580 TIGRFAM TIGR00702 TIGR00702: YcaO-type kinase domain 23 383 6.7E-27 T 13-10-2018 IPR003776 YcaO-like domain TOPB45_1515 f5a6fdffab5d2451b5f8428e3fbf2342 580 Gene3D G3DSA:2.40.50.820 109 180 1.2E-28 T 13-10-2018 TOPB45_1515 f5a6fdffab5d2451b5f8428e3fbf2342 580 Pfam PF07719 Tetratricopeptide repeat 495 527 3.7E-8 T 13-10-2018 IPR013105 Tetratricopeptide repeat 2 TOPB45_1515 f5a6fdffab5d2451b5f8428e3fbf2342 580 Pfam PF00515 Tetratricopeptide repeat 426 456 8.4E-7 T 13-10-2018 IPR001440 Tetratricopeptide repeat 1 GO:0005515 TOPB45_1515 f5a6fdffab5d2451b5f8428e3fbf2342 580 Gene3D G3DSA:1.25.40.10 394 460 4.8E-7 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_1515 f5a6fdffab5d2451b5f8428e3fbf2342 580 Pfam PF13181 Tetratricopeptide repeat 532 561 0.042 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_1515 f5a6fdffab5d2451b5f8428e3fbf2342 580 Pfam PF02624 YcaO cyclodehydratase, ATP-ad Mg2+-binding 76 383 1.9E-57 T 13-10-2018 IPR003776 YcaO-like domain TOPB45_0533 ef86eb077ee0e8249e1a879c80d1bbac 377 Gene3D G3DSA:3.50.30.20 3 151 3.8E-61 T 13-10-2018 IPR036480 Carbamoyl-phosphate synthase small subunit, N-terminal domain superfamily KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400|MetaCyc: PWY-7790|MetaCyc: PWY-7791 TOPB45_0533 ef86eb077ee0e8249e1a879c80d1bbac 377 SUPERFAMILY SSF52317 181 370 1.46E-58 T 13-10-2018 IPR029062 Class I glutamine amidotransferase-like TOPB45_0533 ef86eb077ee0e8249e1a879c80d1bbac 377 Gene3D G3DSA:3.40.50.880 153 370 4.0E-65 T 13-10-2018 IPR029062 Class I glutamine amidotransferase-like TOPB45_0533 ef86eb077ee0e8249e1a879c80d1bbac 377 PRINTS PR00096 Glutamine amidotransferase superfamily signature 258 269 1.2E-12 T 13-10-2018 TOPB45_0533 ef86eb077ee0e8249e1a879c80d1bbac 377 PRINTS PR00096 Glutamine amidotransferase superfamily signature 231 240 1.2E-12 T 13-10-2018 TOPB45_0533 ef86eb077ee0e8249e1a879c80d1bbac 377 PRINTS PR00096 Glutamine amidotransferase superfamily signature 343 356 1.2E-12 T 13-10-2018 TOPB45_0533 ef86eb077ee0e8249e1a879c80d1bbac 377 PRINTS PR00097 Anthranilate synthase component II signature 258 269 1.7E-7 T 13-10-2018 TOPB45_0533 ef86eb077ee0e8249e1a879c80d1bbac 377 PRINTS PR00097 Anthranilate synthase component II signature 231 240 1.7E-7 T 13-10-2018 TOPB45_0533 ef86eb077ee0e8249e1a879c80d1bbac 377 PRINTS PR00097 Anthranilate synthase component II signature 343 356 1.7E-7 T 13-10-2018 TOPB45_0533 ef86eb077ee0e8249e1a879c80d1bbac 377 Hamap MF_01209 Carbamoyl-phosphate synthase small chain [carA]. 4 372 47.773 T 13-10-2018 IPR006274 Carbamoyl-phosphate synthase, small subunit GO:0004088|GO:0006207|GO:0006541 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400|MetaCyc: PWY-7790|MetaCyc: PWY-7791 TOPB45_0533 ef86eb077ee0e8249e1a879c80d1bbac 377 Pfam PF00117 Glutamine amidotransferase class-I 191 366 2.4E-42 T 13-10-2018 IPR017926 Glutamine amidotransferase TOPB45_0533 ef86eb077ee0e8249e1a879c80d1bbac 377 PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature 228 242 3.1E-38 T 13-10-2018 TOPB45_0533 ef86eb077ee0e8249e1a879c80d1bbac 377 PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature 189 203 3.1E-38 T 13-10-2018 TOPB45_0533 ef86eb077ee0e8249e1a879c80d1bbac 377 PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature 275 292 3.1E-38 T 13-10-2018 TOPB45_0533 ef86eb077ee0e8249e1a879c80d1bbac 377 PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature 258 274 3.1E-38 T 13-10-2018 TOPB45_0533 ef86eb077ee0e8249e1a879c80d1bbac 377 PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature 300 311 3.1E-38 T 13-10-2018 TOPB45_0533 ef86eb077ee0e8249e1a879c80d1bbac 377 Pfam PF00988 Carbamoyl-phosphate synthase small chain, CPSase domain 6 133 1.2E-55 T 13-10-2018 IPR002474 Carbamoyl-phosphate synthase small subunit, N-terminal domain KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400|MetaCyc: PWY-7790|MetaCyc: PWY-7791 TOPB45_0533 ef86eb077ee0e8249e1a879c80d1bbac 377 SUPERFAMILY SSF52021 4 150 6.41E-60 T 13-10-2018 IPR036480 Carbamoyl-phosphate synthase small subunit, N-terminal domain superfamily KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400|MetaCyc: PWY-7790|MetaCyc: PWY-7791 TOPB45_0533 ef86eb077ee0e8249e1a879c80d1bbac 377 SMART SM01097 4 134 2.0E-91 T 13-10-2018 IPR002474 Carbamoyl-phosphate synthase small subunit, N-terminal domain KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400|MetaCyc: PWY-7790|MetaCyc: PWY-7791 TOPB45_0533 ef86eb077ee0e8249e1a879c80d1bbac 377 TIGRFAM TIGR01368 CPSaseIIsmall: carbamoyl-phosphate synthase, small subunit 7 368 2.1E-151 T 13-10-2018 IPR006274 Carbamoyl-phosphate synthase, small subunit GO:0004088|GO:0006207|GO:0006541 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400|MetaCyc: PWY-7790|MetaCyc: PWY-7791 TOPB45_0439 76b80a54302e89f9c88230f800220a5b 571 SUPERFAMILY SSF52540 261 477 3.06E-59 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0439 76b80a54302e89f9c88230f800220a5b 571 ProSitePatterns PS00211 ABC transporters family signature. 143 157 - T 13-10-2018 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TOPB45_0439 76b80a54302e89f9c88230f800220a5b 571 SMART SM00382 34 218 3.4E-10 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_0439 76b80a54302e89f9c88230f800220a5b 571 SMART SM00382 287 474 1.2E-14 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_0439 76b80a54302e89f9c88230f800220a5b 571 Gene3D G3DSA:3.40.50.300 2 235 2.4E-61 T 13-10-2018 TOPB45_0439 76b80a54302e89f9c88230f800220a5b 571 Gene3D G3DSA:3.40.50.300 251 493 1.4E-62 T 13-10-2018 TOPB45_0439 76b80a54302e89f9c88230f800220a5b 571 Pfam PF00005 ABC transporter 279 418 9.0E-29 T 13-10-2018 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TOPB45_0439 76b80a54302e89f9c88230f800220a5b 571 Pfam PF00005 ABC transporter 26 170 6.5E-27 T 13-10-2018 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TOPB45_0439 76b80a54302e89f9c88230f800220a5b 571 SUPERFAMILY SSF52540 5 234 1.49E-58 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0453 9c6385830436466afa48cdf0257a1db9 293 PRINTS PR00146 Dihydrodipicolinate synthase signature 103 119 2.3E-29 T 13-10-2018 IPR002220 DapA-like GO:0016829 TOPB45_0453 9c6385830436466afa48cdf0257a1db9 293 PRINTS PR00146 Dihydrodipicolinate synthase signature 35 56 2.3E-29 T 13-10-2018 IPR002220 DapA-like GO:0016829 TOPB45_0453 9c6385830436466afa48cdf0257a1db9 293 PRINTS PR00146 Dihydrodipicolinate synthase signature 71 89 2.3E-29 T 13-10-2018 IPR002220 DapA-like GO:0016829 TOPB45_0453 9c6385830436466afa48cdf0257a1db9 293 PRINTS PR00146 Dihydrodipicolinate synthase signature 128 145 2.3E-29 T 13-10-2018 IPR002220 DapA-like GO:0016829 TOPB45_0453 9c6385830436466afa48cdf0257a1db9 293 Gene3D G3DSA:3.20.20.70 1 290 9.3E-113 T 13-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 TOPB45_0453 9c6385830436466afa48cdf0257a1db9 293 SMART SM01130 2 290 5.2E-135 T 13-10-2018 IPR002220 DapA-like GO:0016829 TOPB45_0453 9c6385830436466afa48cdf0257a1db9 293 TIGRFAM TIGR00674 dapA: 4-hydroxy-tetrahydrodipicolinate synthase 5 288 1.5E-107 T 13-10-2018 IPR005263 4-hydroxy-tetrahydrodipicolinate synthase, DapA GO:0008840|GO:0009089 KEGG: 00261+4.3.3.7|KEGG: 00300+4.3.3.7|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TOPB45_0453 9c6385830436466afa48cdf0257a1db9 293 Hamap MF_00418 4-hydroxy-tetrahydrodipicolinate synthase [dapA]. 2 288 63.645 T 13-10-2018 IPR005263 4-hydroxy-tetrahydrodipicolinate synthase, DapA GO:0008840|GO:0009089 KEGG: 00261+4.3.3.7|KEGG: 00300+4.3.3.7|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TOPB45_0453 9c6385830436466afa48cdf0257a1db9 293 ProSitePatterns PS00666 Dihydrodipicolinate synthase signature 2. 133 163 - T 13-10-2018 IPR020625 Schiff base-forming aldolase, active site GO:0016829 KEGG: 00261+4.3.3.7|KEGG: 00300+4.3.3.7|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|Reactome: R-HSA-389661 TOPB45_0453 9c6385830436466afa48cdf0257a1db9 293 ProSitePatterns PS00665 Dihydrodipicolinate synthase signature 1. 38 55 - T 13-10-2018 IPR020624 Schiff base-forming aldolase, conserved site GO:0016829 KEGG: 00261+4.3.3.7|KEGG: 00300+4.3.3.7|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TOPB45_0453 9c6385830436466afa48cdf0257a1db9 293 SUPERFAMILY SSF51569 2 288 3.24E-101 T 13-10-2018 TOPB45_0453 9c6385830436466afa48cdf0257a1db9 293 PIRSF PIRSF001365 1 292 4.3E-95 T 13-10-2018 IPR002220 DapA-like GO:0016829 TOPB45_0453 9c6385830436466afa48cdf0257a1db9 293 Pfam PF00701 Dihydrodipicolinate synthetase family 3 288 7.4E-97 T 13-10-2018 IPR002220 DapA-like GO:0016829 TOPB45_1605 6c90f34802aa41e81cff5468f22f5cfc 124 Pfam PF03692 Putative zinc- or iron-chelating domain 5 105 1.8E-14 T 13-10-2018 IPR005358 Putative zinc- or iron-chelating domain containing protein TOPB45_1144 c420074c8448e493390f3a1c05542c02 153 TIGRFAM TIGR00725 TIGR00725: TIGR00725 family protein 7 126 7.1E-44 T 13-10-2018 IPR005268 Conserved hypothetical protein CHP00725 TOPB45_1144 c420074c8448e493390f3a1c05542c02 153 Gene3D G3DSA:3.40.50.450 1 153 6.4E-42 T 13-10-2018 TOPB45_1144 c420074c8448e493390f3a1c05542c02 153 Pfam PF03641 Possible lysine decarboxylase 47 117 1.2E-9 T 13-10-2018 IPR031100 LOG family TOPB45_1144 c420074c8448e493390f3a1c05542c02 153 SUPERFAMILY SSF102405 6 151 9.62E-36 T 13-10-2018 TOPB45_0824 cb188e5a7aca78e5ce032357b80bbe48 460 Gene3D G3DSA:3.40.50.300 126 310 8.0E-67 T 13-10-2018 TOPB45_0824 cb188e5a7aca78e5ce032357b80bbe48 460 Gene3D G3DSA:1.10.8.60 311 389 1.1E-26 T 13-10-2018 TOPB45_0824 cb188e5a7aca78e5ce032357b80bbe48 460 ProSitePatterns PS00675 Sigma-54 interaction domain ATP-binding region A signature. 164 177 - T 13-10-2018 IPR025662 Sigma-54 interaction domain, ATP-binding site 1 TOPB45_0824 cb188e5a7aca78e5ce032357b80bbe48 460 Gene3D G3DSA:3.40.50.2300 4 121 8.0E-33 T 13-10-2018 TOPB45_0824 cb188e5a7aca78e5ce032357b80bbe48 460 Gene3D G3DSA:1.10.10.60 392 457 1.7E-12 T 13-10-2018 TOPB45_0824 cb188e5a7aca78e5ce032357b80bbe48 460 Pfam PF00072 Response regulator receiver domain 5 112 1.4E-25 T 13-10-2018 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TOPB45_0824 cb188e5a7aca78e5ce032357b80bbe48 460 ProSitePatterns PS00676 Sigma-54 interaction domain ATP-binding region B signature. 226 241 - T 13-10-2018 IPR025943 Sigma-54 interaction domain, ATP-binding site 2 TOPB45_0824 cb188e5a7aca78e5ce032357b80bbe48 460 SMART SM00448 3 114 1.5E-25 T 13-10-2018 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TOPB45_0824 cb188e5a7aca78e5ce032357b80bbe48 460 SUPERFAMILY SSF52540 140 382 9.86E-73 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0824 cb188e5a7aca78e5ce032357b80bbe48 460 Pfam PF02954 Bacterial regulatory protein, Fis family 415 452 8.2E-6 T 13-10-2018 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 TOPB45_0824 cb188e5a7aca78e5ce032357b80bbe48 460 PRINTS PR01590 FIS bacterial regulatory protein HTH signature 435 455 1.2E-5 T 13-10-2018 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 TOPB45_0824 cb188e5a7aca78e5ce032357b80bbe48 460 PRINTS PR01590 FIS bacterial regulatory protein HTH signature 418 435 1.2E-5 T 13-10-2018 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 TOPB45_0824 cb188e5a7aca78e5ce032357b80bbe48 460 ProSitePatterns PS00688 Sigma-54 interaction domain C-terminal part signature. 353 362 - T 13-10-2018 IPR025944 Sigma-54 interaction domain, conserved site TOPB45_0824 cb188e5a7aca78e5ce032357b80bbe48 460 SMART SM00382 160 303 1.3E-10 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_0824 cb188e5a7aca78e5ce032357b80bbe48 460 Pfam PF00158 Sigma-54 interaction domain 141 306 3.7E-70 T 13-10-2018 IPR002078 RNA polymerase sigma factor 54 interaction domain GO:0005524|GO:0006355|GO:0008134 TOPB45_0824 cb188e5a7aca78e5ce032357b80bbe48 460 SUPERFAMILY SSF46689 353 454 2.37E-13 T 13-10-2018 IPR009057 Homeobox-like domain superfamily GO:0003677 TOPB45_0824 cb188e5a7aca78e5ce032357b80bbe48 460 SUPERFAMILY SSF52172 5 184 6.69E-36 T 13-10-2018 IPR011006 CheY-like superfamily TOPB45_0264 45765ed24e1862b3687ea9ed1951a22b 244 SUPERFAMILY SSF141523 39 170 1.18E-31 T 13-10-2018 IPR038063 L,D-transpeptidase catalytic domain-like TOPB45_0264 45765ed24e1862b3687ea9ed1951a22b 244 Gene3D G3DSA:2.40.440.10 1 240 5.7E-66 T 13-10-2018 IPR038063 L,D-transpeptidase catalytic domain-like TOPB45_0264 45765ed24e1862b3687ea9ed1951a22b 244 Pfam PF03734 L,D-transpeptidase catalytic domain 42 170 3.5E-23 T 13-10-2018 IPR005490 L,D-transpeptidase catalytic domain GO:0016740 TOPB45_1400 c394164175b95c09f678c4431508e65b 648 SMART SM00861 330 500 1.4E-27 T 13-10-2018 IPR005475 Transketolase-like, pyrimidine-binding domain TOPB45_1400 c394164175b95c09f678c4431508e65b 648 SUPERFAMILY SSF52922 517 647 1.44E-25 T 13-10-2018 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824 TOPB45_1400 c394164175b95c09f678c4431508e65b 648 Gene3D G3DSA:3.40.50.970 9 308 2.1E-85 T 13-10-2018 TOPB45_1400 c394164175b95c09f678c4431508e65b 648 Pfam PF02780 Transketolase, C-terminal domain 519 638 6.8E-21 T 13-10-2018 IPR033248 Transketolase, C-terminal domain TOPB45_1400 c394164175b95c09f678c4431508e65b 648 Pfam PF00456 Transketolase, thiamine diphosphate binding domain 36 289 1.0E-44 T 13-10-2018 IPR005474 Transketolase, N-terminal KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 TOPB45_1400 c394164175b95c09f678c4431508e65b 648 SUPERFAMILY SSF52518 323 501 4.87E-37 T 13-10-2018 IPR029061 Thiamin diphosphate-binding fold TOPB45_1400 c394164175b95c09f678c4431508e65b 648 SUPERFAMILY SSF52518 7 296 4.29E-69 T 13-10-2018 IPR029061 Thiamin diphosphate-binding fold TOPB45_1400 c394164175b95c09f678c4431508e65b 648 Gene3D G3DSA:3.40.50.970 320 507 1.7E-49 T 13-10-2018 TOPB45_1400 c394164175b95c09f678c4431508e65b 648 Pfam PF02779 Transketolase, pyrimidine binding domain 330 491 6.6E-18 T 13-10-2018 IPR005475 Transketolase-like, pyrimidine-binding domain TOPB45_1400 c394164175b95c09f678c4431508e65b 648 Gene3D G3DSA:3.40.50.920 519 648 8.4E-29 T 13-10-2018 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824 TOPB45_0074 5ac889ad231b24a7421fe45ed5885c21 277 Pfam PF00288 GHMP kinases N terminal domain 87 130 5.6E-9 T 13-10-2018 IPR006204 GHMP kinase N-terminal domain GO:0005524 TOPB45_0074 5ac889ad231b24a7421fe45ed5885c21 277 TIGRFAM TIGR00154 ispE: 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase 4 252 8.7E-55 T 13-10-2018 IPR004424 4-diphosphocytidyl-2C-methyl-D-erythritol kinase GO:0016114|GO:0050515 KEGG: 00900+2.7.1.148|MetaCyc: PWY-7560 TOPB45_0074 5ac889ad231b24a7421fe45ed5885c21 277 SUPERFAMILY SSF54211 4 155 5.46E-33 T 13-10-2018 IPR020568 Ribosomal protein S5 domain 2-type fold TOPB45_0074 5ac889ad231b24a7421fe45ed5885c21 277 Hamap MF_00061 Putative 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase [ispE]. 4 273 27.897 T 13-10-2018 IPR004424 4-diphosphocytidyl-2C-methyl-D-erythritol kinase GO:0016114|GO:0050515 KEGG: 00900+2.7.1.148|MetaCyc: PWY-7560 TOPB45_0074 5ac889ad231b24a7421fe45ed5885c21 277 Pfam PF08544 GHMP kinases C terminal 213 261 3.1E-6 T 13-10-2018 IPR013750 GHMP kinase, C-terminal domain TOPB45_0074 5ac889ad231b24a7421fe45ed5885c21 277 Gene3D G3DSA:3.30.70.890 160 277 2.2E-20 T 13-10-2018 IPR036554 GHMP kinase, C-terminal domain superfamily TOPB45_0074 5ac889ad231b24a7421fe45ed5885c21 277 Gene3D G3DSA:3.30.230.10 2 157 3.9E-47 T 13-10-2018 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup TOPB45_0074 5ac889ad231b24a7421fe45ed5885c21 277 SUPERFAMILY SSF55060 162 271 4.65E-17 T 13-10-2018 IPR036554 GHMP kinase, C-terminal domain superfamily TOPB45_0074 5ac889ad231b24a7421fe45ed5885c21 277 PIRSF PIRSF010376 2 275 2.2E-70 T 13-10-2018 IPR004424 4-diphosphocytidyl-2C-methyl-D-erythritol kinase GO:0016114|GO:0050515 KEGG: 00900+2.7.1.148|MetaCyc: PWY-7560 TOPB45_0546 ffa86146bedc2395de74cdb877179863 118 Hamap MF_00382 50S ribosomal protein L20 [rplT]. 2 115 29.381 T 13-10-2018 IPR005813 Ribosomal protein L20 GO:0003735|GO:0005622|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0546 ffa86146bedc2395de74cdb877179863 118 SUPERFAMILY SSF74731 2 115 6.28E-49 T 13-10-2018 IPR035566 Ribosomal protein L20, C-terminal Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0546 ffa86146bedc2395de74cdb877179863 118 PRINTS PR00062 Ribosomal protein L20 signature 75 101 8.4E-40 T 13-10-2018 IPR005813 Ribosomal protein L20 GO:0003735|GO:0005622|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0546 ffa86146bedc2395de74cdb877179863 118 PRINTS PR00062 Ribosomal protein L20 signature 12 41 8.4E-40 T 13-10-2018 IPR005813 Ribosomal protein L20 GO:0003735|GO:0005622|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0546 ffa86146bedc2395de74cdb877179863 118 PRINTS PR00062 Ribosomal protein L20 signature 42 71 8.4E-40 T 13-10-2018 IPR005813 Ribosomal protein L20 GO:0003735|GO:0005622|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0546 ffa86146bedc2395de74cdb877179863 118 Gene3D G3DSA:1.10.1900.20 56 118 1.3E-29 T 13-10-2018 IPR035566 Ribosomal protein L20, C-terminal Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0546 ffa86146bedc2395de74cdb877179863 118 Pfam PF00453 Ribosomal protein L20 3 109 2.8E-48 T 13-10-2018 IPR005813 Ribosomal protein L20 GO:0003735|GO:0005622|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0546 ffa86146bedc2395de74cdb877179863 118 ProDom PD002389 RIBOSOMAL RRNA-BINDING RNA-BINDING RIBONUCLEOPROTEIN L20 50S L20 CHLOROPLAST BACTERIAL ORGANELLE 21 70 3.0E-7 T 13-10-2018 TOPB45_0546 ffa86146bedc2395de74cdb877179863 118 TIGRFAM TIGR01032 rplT_bact: ribosomal protein bL20 1 114 2.2E-48 T 13-10-2018 IPR005813 Ribosomal protein L20 GO:0003735|GO:0005622|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0546 ffa86146bedc2395de74cdb877179863 118 Gene3D G3DSA:1.10.720.90 2 55 2.2E-24 T 13-10-2018 TOPB45_0926 8f4d613930dd297b754b31cbf3df8441 190 SUPERFAMILY SSF54523 6 80 2.51E-11 T 13-10-2018 TOPB45_0926 8f4d613930dd297b754b31cbf3df8441 190 ProSitePatterns PS00409 Prokaryotic N-terminal methylation site. 4 24 - T 13-10-2018 IPR012902 Prokaryotic N-terminal methylation site TOPB45_0926 8f4d613930dd297b754b31cbf3df8441 190 Pfam PF07963 Prokaryotic N-terminal methylation motif 2 26 5.9E-7 T 13-10-2018 IPR012902 Prokaryotic N-terminal methylation site TOPB45_0926 8f4d613930dd297b754b31cbf3df8441 190 TIGRFAM TIGR02532 IV_pilin_GFxxxE: prepilin-type N-terminal cleavage/methylation domain 3 26 1.8E-6 T 13-10-2018 IPR012902 Prokaryotic N-terminal methylation site TOPB45_0926 8f4d613930dd297b754b31cbf3df8441 190 Gene3D G3DSA:3.30.700.10 6 134 1.9E-8 T 13-10-2018 TOPB45_0047 3119ba01af217b30247ca3c87f87bd7f 359 Pfam PF02163 Peptidase family M50 7 340 5.2E-82 T 13-10-2018 IPR008915 Peptidase M50 GO:0004222|GO:0006508 Reactome: R-HSA-1655829|Reactome: R-HSA-381033|Reactome: R-HSA-8874211|Reactome: R-HSA-8963889 TOPB45_0047 3119ba01af217b30247ca3c87f87bd7f 359 Pfam PF00595 PDZ domain (Also known as DHR or GLGF) 125 180 7.8E-11 T 13-10-2018 IPR001478 PDZ domain GO:0005515 TOPB45_0047 3119ba01af217b30247ca3c87f87bd7f 359 SUPERFAMILY SSF50156 88 192 4.34E-22 T 13-10-2018 IPR036034 PDZ superfamily GO:0005515 TOPB45_0047 3119ba01af217b30247ca3c87f87bd7f 359 Gene3D G3DSA:2.30.42.10 123 219 4.9E-20 T 13-10-2018 TOPB45_0047 3119ba01af217b30247ca3c87f87bd7f 359 SMART SM00228 112 183 1.4E-14 T 13-10-2018 IPR001478 PDZ domain GO:0005515 TOPB45_0047 3119ba01af217b30247ca3c87f87bd7f 359 TIGRFAM TIGR00054 TIGR00054: RIP metalloprotease RseP 126 353 1.0E-56 T 13-10-2018 IPR004387 Peptidase M50, putative membrane-associated zinc metallopeptidase GO:0004222|GO:0006508|GO:0016021 TOPB45_0712 306c8d3d325e334894d59b55c1c29956 484 Pfam PF02785 Biotin carboxylase C-terminal domain 340 447 3.9E-35 T 13-10-2018 IPR005482 Biotin carboxylase, C-terminal Reactome: R-HSA-196780|Reactome: R-HSA-3371599 TOPB45_0712 306c8d3d325e334894d59b55c1c29956 484 ProSitePatterns PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 156 170 - T 13-10-2018 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 TOPB45_0712 306c8d3d325e334894d59b55c1c29956 484 SUPERFAMILY SSF52440 2 115 2.09E-47 T 13-10-2018 IPR016185 Pre-ATP-grasp domain superfamily TOPB45_0712 306c8d3d325e334894d59b55c1c29956 484 SUPERFAMILY SSF56059 85 350 7.07E-66 T 13-10-2018 TOPB45_0712 306c8d3d325e334894d59b55c1c29956 484 Gene3D G3DSA:3.30.470.130 1 454 4.5E-181 T 13-10-2018 TOPB45_0712 306c8d3d325e334894d59b55c1c29956 484 Pfam PF00289 Biotin carboxylase, N-terminal domain 3 112 5.7E-43 T 13-10-2018 IPR005481 Biotin carboxylase-like, N-terminal domain Reactome: R-HSA-196780|Reactome: R-HSA-3371599 TOPB45_0712 306c8d3d325e334894d59b55c1c29956 484 Pfam PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 117 326 8.8E-67 T 13-10-2018 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 TOPB45_0712 306c8d3d325e334894d59b55c1c29956 484 SMART SM00878 340 446 7.1E-53 T 13-10-2018 IPR005482 Biotin carboxylase, C-terminal Reactome: R-HSA-196780|Reactome: R-HSA-3371599 TOPB45_0712 306c8d3d325e334894d59b55c1c29956 484 SUPERFAMILY SSF51246 336 452 1.15E-35 T 13-10-2018 IPR011054 Rudiment single hybrid motif Reactome: R-HSA-196780 TOPB45_0712 306c8d3d325e334894d59b55c1c29956 484 ProSitePatterns PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 290 297 - T 13-10-2018 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 TOPB45_1386 e73495fa289a26a48c069c1ed548dddc 333 SMART SM00846 2 154 6.5E-76 T 13-10-2018 IPR020828 Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_1386 e73495fa289a26a48c069c1ed548dddc 333 SUPERFAMILY SSF55347 154 312 3.87E-45 T 13-10-2018 TOPB45_1386 e73495fa289a26a48c069c1ed548dddc 333 Gene3D G3DSA:3.30.360.10 153 313 3.7E-118 T 13-10-2018 TOPB45_1386 e73495fa289a26a48c069c1ed548dddc 333 PIRSF PIRSF000149 1 333 2.6E-106 T 13-10-2018 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_1386 e73495fa289a26a48c069c1ed548dddc 333 SUPERFAMILY SSF51735 3 170 4.33E-53 T 13-10-2018 IPR036291 NAD(P)-binding domain superfamily TOPB45_1386 e73495fa289a26a48c069c1ed548dddc 333 Gene3D G3DSA:3.40.50.720 3 327 3.7E-118 T 13-10-2018 TOPB45_1386 e73495fa289a26a48c069c1ed548dddc 333 Pfam PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 160 311 8.9E-41 T 13-10-2018 IPR020829 Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_1386 e73495fa289a26a48c069c1ed548dddc 333 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 111 124 3.2E-23 T 13-10-2018 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_1386 e73495fa289a26a48c069c1ed548dddc 333 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 231 248 3.2E-23 T 13-10-2018 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_1386 e73495fa289a26a48c069c1ed548dddc 333 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 175 191 3.2E-23 T 13-10-2018 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_1386 e73495fa289a26a48c069c1ed548dddc 333 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 267 282 3.2E-23 T 13-10-2018 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_1386 e73495fa289a26a48c069c1ed548dddc 333 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 148 166 3.2E-23 T 13-10-2018 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_1386 e73495fa289a26a48c069c1ed548dddc 333 Pfam PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 3 104 9.9E-34 T 13-10-2018 IPR020828 Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_0770 b07127d547fceee539e42425485748c7 167 Gene3D G3DSA:3.30.230.10 71 164 2.2E-37 T 13-10-2018 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup TOPB45_0770 b07127d547fceee539e42425485748c7 167 Pfam PF03719 Ribosomal protein S5, C-terminal domain 85 154 4.5E-31 T 13-10-2018 IPR005324 Ribosomal protein S5, C-terminal GO:0003735|GO:0005840|GO:0006412 TOPB45_0770 b07127d547fceee539e42425485748c7 167 SUPERFAMILY SSF54211 76 156 1.72E-26 T 13-10-2018 IPR020568 Ribosomal protein S5 domain 2-type fold TOPB45_0770 b07127d547fceee539e42425485748c7 167 SUPERFAMILY SSF54768 5 73 1.26E-24 T 13-10-2018 TOPB45_0770 b07127d547fceee539e42425485748c7 167 Hamap MF_01307_B 30S ribosomal protein S5 [rpsE]. 1 160 35.03 T 13-10-2018 IPR005712 Ribosomal protein S5, bacterial-type GO:0003735|GO:0006412|GO:0015935 TOPB45_0770 b07127d547fceee539e42425485748c7 167 Pfam PF00333 Ribosomal protein S5, N-terminal domain 9 72 7.0E-31 T 13-10-2018 IPR013810 Ribosomal protein S5, N-terminal GO:0003723|GO:0003735|GO:0005840|GO:0006412 TOPB45_0770 b07127d547fceee539e42425485748c7 167 Gene3D G3DSA:3.30.160.20 1 70 6.5E-32 T 13-10-2018 TOPB45_0770 b07127d547fceee539e42425485748c7 167 TIGRFAM TIGR01021 rpsE_bact: ribosomal protein uS5 6 160 4.5E-68 T 13-10-2018 IPR005712 Ribosomal protein S5, bacterial-type GO:0003735|GO:0006412|GO:0015935 TOPB45_0770 b07127d547fceee539e42425485748c7 167 ProSitePatterns PS00585 Ribosomal protein S5 signature. 25 57 - T 13-10-2018 IPR018192 Ribosomal protein S5, N-terminal, conserved site TOPB45_0027 770c3baf6023f724db160bd23206f364 382 SUPERFAMILY SSF53756 8 375 5.5E-32 T 13-10-2018 TOPB45_0027 770c3baf6023f724db160bd23206f364 382 Pfam PF02684 Lipid-A-disaccharide synthetase 9 354 2.3E-93 T 13-10-2018 IPR003835 Glycosyl transferase, family 19 GO:0008915|GO:0009245 KEGG: 00540+2.4.1.182 TOPB45_0027 770c3baf6023f724db160bd23206f364 382 TIGRFAM TIGR00215 lpxB: lipid-A-disaccharide synthase 6 373 4.4E-76 T 13-10-2018 IPR003835 Glycosyl transferase, family 19 GO:0008915|GO:0009245 KEGG: 00540+2.4.1.182 TOPB45_1206 e92d582e643c31c1fb0c01a4f28e64e7 62 Pfam PF13237 4Fe-4S dicluster domain 5 53 6.1E-10 T 13-10-2018 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain TOPB45_1206 e92d582e643c31c1fb0c01a4f28e64e7 62 Gene3D G3DSA:3.30.70.20 4 62 7.7E-14 T 13-10-2018 TOPB45_1206 e92d582e643c31c1fb0c01a4f28e64e7 62 SUPERFAMILY SSF54862 3 59 4.37E-16 T 13-10-2018 TOPB45_1206 e92d582e643c31c1fb0c01a4f28e64e7 62 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 42 53 - T 13-10-2018 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site TOPB45_1449 963404c94092bdd7bd9b9e8b15f2cf03 1013 Pfam PF01568 Molydopterin dinucleotide binding domain 886 1004 3.3E-19 T 13-10-2018 IPR006657 Molybdopterin dinucleotide-binding domain GO:0016491|GO:0043546|GO:0055114 TOPB45_1449 963404c94092bdd7bd9b9e8b15f2cf03 1013 Gene3D G3DSA:3.30.200.210 32 150 1.6E-25 T 13-10-2018 TOPB45_1449 963404c94092bdd7bd9b9e8b15f2cf03 1013 Gene3D G3DSA:2.40.40.20 832 1013 8.4E-75 T 13-10-2018 TOPB45_1449 963404c94092bdd7bd9b9e8b15f2cf03 1013 Gene3D G3DSA:3.40.228.10 744 831 1.7E-22 T 13-10-2018 TOPB45_1449 963404c94092bdd7bd9b9e8b15f2cf03 1013 Gene3D G3DSA:3.40.50.740 482 676 1.2E-70 T 13-10-2018 TOPB45_1449 963404c94092bdd7bd9b9e8b15f2cf03 1013 SMART SM00926 42 96 4.4E-25 T 13-10-2018 IPR006963 Molybdopterin oxidoreductase, 4Fe-4S domain GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_1449 963404c94092bdd7bd9b9e8b15f2cf03 1013 SUPERFAMILY SSF53706 36 842 0.0 T 13-10-2018 TOPB45_1449 963404c94092bdd7bd9b9e8b15f2cf03 1013 Pfam PF00384 Molybdopterin oxidoreductase 99 652 1.8E-47 T 13-10-2018 IPR006656 Molybdopterin oxidoreductase GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_1449 963404c94092bdd7bd9b9e8b15f2cf03 1013 PIRSF PIRSF036643 510 664 9.9E-20 T 13-10-2018 TOPB45_1449 963404c94092bdd7bd9b9e8b15f2cf03 1013 PIRSF PIRSF036643 331 473 1.4E-24 T 13-10-2018 TOPB45_1449 963404c94092bdd7bd9b9e8b15f2cf03 1013 PIRSF PIRSF036643 849 1013 3.2E-16 T 13-10-2018 TOPB45_1449 963404c94092bdd7bd9b9e8b15f2cf03 1013 PIRSF PIRSF036643 25 312 4.3E-69 T 13-10-2018 TOPB45_1449 963404c94092bdd7bd9b9e8b15f2cf03 1013 SUPERFAMILY SSF50692 822 1013 6.01E-49 T 13-10-2018 IPR009010 Aspartate decarboxylase-like domain superfamily TOPB45_1449 963404c94092bdd7bd9b9e8b15f2cf03 1013 TIGRFAM TIGR01553 formate-DH-alph: formate dehydrogenase-N alpha subunit 5 1012 0.0 T 13-10-2018 IPR006443 Formate dehydrogenase-N, alpha subunit GO:0008863|GO:0009055|GO:0043546|GO:0045333|GO:0047111 TOPB45_1449 963404c94092bdd7bd9b9e8b15f2cf03 1013 Gene3D G3DSA:3.40.228.10 184 476 9.1E-92 T 13-10-2018 TOPB45_1449 963404c94092bdd7bd9b9e8b15f2cf03 1013 Pfam PF04879 Molybdopterin oxidoreductase Fe4S4 domain 43 96 1.0E-21 T 13-10-2018 IPR006963 Molybdopterin oxidoreductase, 4Fe-4S domain GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_0252 f792cb7274d4f0561042b47d2e48f044 368 Pfam PF03462 PCRF domain 14 208 4.4E-78 T 13-10-2018 IPR005139 Peptide chain release factor GO:0006415 TOPB45_0252 f792cb7274d4f0561042b47d2e48f044 368 Gene3D G3DSA:3.30.160.20 215 301 5.7E-106 T 13-10-2018 TOPB45_0252 f792cb7274d4f0561042b47d2e48f044 368 SUPERFAMILY SSF75620 14 356 1.44E-142 T 13-10-2018 TOPB45_0252 f792cb7274d4f0561042b47d2e48f044 368 Hamap MF_00093 Peptide chain release factor 1 [prfA]. 7 361 40.724 T 13-10-2018 IPR004373 Peptide chain release factor 1 GO:0005737|GO:0006415|GO:0016149 TOPB45_0252 f792cb7274d4f0561042b47d2e48f044 368 Pfam PF00472 RF-1 domain 216 325 5.4E-43 T 13-10-2018 IPR000352 Peptide chain release factor class I/class II GO:0003747|GO:0006415 TOPB45_0252 f792cb7274d4f0561042b47d2e48f044 368 ProSitePatterns PS00745 Prokaryotic-type class I peptide chain release factors signature. 232 248 - T 13-10-2018 IPR000352 Peptide chain release factor class I/class II GO:0003747|GO:0006415 TOPB45_0252 f792cb7274d4f0561042b47d2e48f044 368 Gene3D G3DSA:1.20.58.410 3 100 5.9E-9 T 13-10-2018 TOPB45_0252 f792cb7274d4f0561042b47d2e48f044 368 Gene3D G3DSA:3.30.70.1660 116 346 5.7E-106 T 13-10-2018 TOPB45_0252 f792cb7274d4f0561042b47d2e48f044 368 TIGRFAM TIGR00019 prfA: peptide chain release factor 1 6 360 1.8E-167 T 13-10-2018 IPR004373 Peptide chain release factor 1 GO:0005737|GO:0006415|GO:0016149 TOPB45_0252 f792cb7274d4f0561042b47d2e48f044 368 SMART SM00937 69 183 4.0E-66 T 13-10-2018 IPR005139 Peptide chain release factor GO:0006415 TOPB45_0965 9c2ab2e931f9b8d6eb88772eee84dec6 328 SUPERFAMILY SSF52833 100 192 2.31E-15 T 13-10-2018 IPR036249 Thioredoxin-like superfamily TOPB45_0965 9c2ab2e931f9b8d6eb88772eee84dec6 328 Gene3D G3DSA:1.25.10.10 192 285 2.5E-6 T 13-10-2018 IPR011989 Armadillo-like helical TOPB45_0965 9c2ab2e931f9b8d6eb88772eee84dec6 328 SUPERFAMILY SSF48371 215 321 7.1E-7 T 13-10-2018 IPR016024 Armadillo-type fold TOPB45_0965 9c2ab2e931f9b8d6eb88772eee84dec6 328 Gene3D G3DSA:3.40.30.80 17 191 1.4E-36 T 13-10-2018 TOPB45_0965 9c2ab2e931f9b8d6eb88772eee84dec6 328 Pfam PF13192 Thioredoxin domain 114 183 2.7E-10 T 13-10-2018 IPR012336 Thioredoxin-like fold TOPB45_0544 b306e898aa54a21711328e2ba6828048 800 Gene3D G3DSA:3.30.930.10 488 693 4.7E-57 T 13-10-2018 TOPB45_0544 b306e898aa54a21711328e2ba6828048 800 Hamap MF_00283 Phenylalanine--tRNA ligase beta subunit [pheT]. 1 794 40.071 T 13-10-2018 IPR004532 Phenylalanine-tRNA ligase, class IIc, beta subunit GO:0000287|GO:0004826|GO:0005524|GO:0005737|GO:0006432 KEGG: 00970+6.1.1.20 TOPB45_0544 b306e898aa54a21711328e2ba6828048 800 Pfam PF03147 Ferredoxin-fold anticodon binding domain 707 800 1.9E-22 T 13-10-2018 IPR005121 Ferrodoxin-fold anticodon-binding domain KEGG: 00970+6.1.1.20 TOPB45_0544 b306e898aa54a21711328e2ba6828048 800 SMART SM00896 707 800 9.5E-30 T 13-10-2018 IPR005121 Ferrodoxin-fold anticodon-binding domain KEGG: 00970+6.1.1.20 TOPB45_0544 b306e898aa54a21711328e2ba6828048 800 SUPERFAMILY SSF50249 40 192 4.54E-21 T 13-10-2018 IPR012340 Nucleic acid-binding, OB-fold TOPB45_0544 b306e898aa54a21711328e2ba6828048 800 SUPERFAMILY SSF56037 205 397 7.32E-66 T 13-10-2018 TOPB45_0544 b306e898aa54a21711328e2ba6828048 800 SMART SM00874 403 470 4.3E-21 T 13-10-2018 IPR005147 tRNA synthetase, B5-domain GO:0000287|GO:0003723|GO:0005524|GO:0006432 KEGG: 00970+6.1.1.20|Reactome: R-HSA-379716 TOPB45_0544 b306e898aa54a21711328e2ba6828048 800 Pfam PF03483 B3/4 domain 214 384 5.1E-62 T 13-10-2018 IPR005146 B3/B4 tRNA-binding domain GO:0003723|GO:0004826 KEGG: 00970+6.1.1.20 TOPB45_0544 b306e898aa54a21711328e2ba6828048 800 Gene3D G3DSA:3.30.70.380 708 800 8.3E-21 T 13-10-2018 IPR036690 Ferrodoxin-fold anticodon-binding domain superfamily KEGG: 00970+6.1.1.20 TOPB45_0544 b306e898aa54a21711328e2ba6828048 800 Pfam PF03484 tRNA synthetase B5 domain 406 470 4.4E-18 T 13-10-2018 IPR005147 tRNA synthetase, B5-domain GO:0000287|GO:0003723|GO:0005524|GO:0006432 KEGG: 00970+6.1.1.20|Reactome: R-HSA-379716 TOPB45_0544 b306e898aa54a21711328e2ba6828048 800 TIGRFAM TIGR00472 pheT_bact: phenylalanine--tRNA ligase, beta subunit 1 798 8.7E-224 T 13-10-2018 IPR004532 Phenylalanine-tRNA ligase, class IIc, beta subunit GO:0000287|GO:0004826|GO:0005524|GO:0005737|GO:0006432 KEGG: 00970+6.1.1.20 TOPB45_0544 b306e898aa54a21711328e2ba6828048 800 Gene3D G3DSA:3.50.40.10 199 396 2.3E-76 T 13-10-2018 IPR020825 Phenylalanyl-tRNA synthetase, B3/B4 KEGG: 00970+6.1.1.20 TOPB45_0544 b306e898aa54a21711328e2ba6828048 800 SMART SM00873 213 386 6.9E-79 T 13-10-2018 IPR005146 B3/B4 tRNA-binding domain GO:0003723|GO:0004826 KEGG: 00970+6.1.1.20 TOPB45_0544 b306e898aa54a21711328e2ba6828048 800 Gene3D G3DSA:3.30.56.10 403 474 4.1E-21 T 13-10-2018 TOPB45_0544 b306e898aa54a21711328e2ba6828048 800 SUPERFAMILY SSF55681 466 691 9.44E-47 T 13-10-2018 TOPB45_0544 b306e898aa54a21711328e2ba6828048 800 Gene3D G3DSA:2.40.50.140 38 155 1.8E-41 T 13-10-2018 TOPB45_0544 b306e898aa54a21711328e2ba6828048 800 SUPERFAMILY SSF54991 703 800 1.44E-25 T 13-10-2018 IPR036690 Ferrodoxin-fold anticodon-binding domain superfamily KEGG: 00970+6.1.1.20 TOPB45_0544 b306e898aa54a21711328e2ba6828048 800 Gene3D G3DSA:3.30.56.10 1 179 1.8E-41 T 13-10-2018 TOPB45_0544 b306e898aa54a21711328e2ba6828048 800 SUPERFAMILY SSF46955 405 474 2.47E-14 T 13-10-2018 IPR009061 Putative DNA-binding domain superfamily TOPB45_1258 36701c2985217872125f4167581583bb 517 SMART SM00382 214 365 3.7E-10 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_1258 36701c2985217872125f4167581583bb 517 ProSitePatterns PS00676 Sigma-54 interaction domain ATP-binding region B signature. 280 295 - T 13-10-2018 IPR025943 Sigma-54 interaction domain, ATP-binding site 2 TOPB45_1258 36701c2985217872125f4167581583bb 517 SUPERFAMILY SSF55781 3 165 6.98E-30 T 13-10-2018 TOPB45_1258 36701c2985217872125f4167581583bb 517 Gene3D G3DSA:3.30.450.40 4 176 8.4E-58 T 13-10-2018 IPR029016 GAF-like domain superfamily TOPB45_1258 36701c2985217872125f4167581583bb 517 Gene3D G3DSA:1.10.10.60 431 502 6.3E-17 T 13-10-2018 TOPB45_1258 36701c2985217872125f4167581583bb 517 SUPERFAMILY SSF46689 406 500 1.93E-13 T 13-10-2018 IPR009057 Homeobox-like domain superfamily GO:0003677 TOPB45_1258 36701c2985217872125f4167581583bb 517 PRINTS PR01590 FIS bacterial regulatory protein HTH signature 464 481 1.5E-10 T 13-10-2018 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 TOPB45_1258 36701c2985217872125f4167581583bb 517 PRINTS PR01590 FIS bacterial regulatory protein HTH signature 481 501 1.5E-10 T 13-10-2018 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 TOPB45_1258 36701c2985217872125f4167581583bb 517 Pfam PF13185 GAF domain 33 165 1.4E-13 T 13-10-2018 IPR003018 GAF domain GO:0005515 TOPB45_1258 36701c2985217872125f4167581583bb 517 Pfam PF00158 Sigma-54 interaction domain 194 360 2.6E-70 T 13-10-2018 IPR002078 RNA polymerase sigma factor 54 interaction domain GO:0005524|GO:0006355|GO:0008134 TOPB45_1258 36701c2985217872125f4167581583bb 517 ProSitePatterns PS00675 Sigma-54 interaction domain ATP-binding region A signature. 218 231 - T 13-10-2018 IPR025662 Sigma-54 interaction domain, ATP-binding site 1 TOPB45_1258 36701c2985217872125f4167581583bb 517 SUPERFAMILY SSF52540 194 435 4.03E-75 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1258 36701c2985217872125f4167581583bb 517 ProSitePatterns PS00688 Sigma-54 interaction domain C-terminal part signature. 406 415 - T 13-10-2018 IPR025944 Sigma-54 interaction domain, conserved site TOPB45_1258 36701c2985217872125f4167581583bb 517 Gene3D G3DSA:3.40.50.300 182 364 3.0E-68 T 13-10-2018 TOPB45_1258 36701c2985217872125f4167581583bb 517 TIGRFAM TIGR01817 nifA: Nif-specific regulatory protein 9 449 7.0E-163 T 13-10-2018 IPR010113 Nif-specific regulatory protein GO:0003700|GO:0006355|GO:0009399 TOPB45_1258 36701c2985217872125f4167581583bb 517 SMART SM00065 26 175 9.6E-21 T 13-10-2018 IPR003018 GAF domain GO:0005515 TOPB45_1258 36701c2985217872125f4167581583bb 517 Pfam PF02954 Bacterial regulatory protein, Fis family 458 498 1.5E-14 T 13-10-2018 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 TOPB45_1258 36701c2985217872125f4167581583bb 517 Gene3D G3DSA:1.10.8.60 365 430 2.6E-29 T 13-10-2018 TOPB45_0621 80b050cb49ca108cf53227db953e7aee 418 ProSitePatterns PS00738 S-adenosyl-L-homocysteine hydrolase signature 1. 74 88 - T 13-10-2018 IPR020082 S-adenosyl-L-homocysteine hydrolase, conserved site GO:0004013 KEGG: 00270+3.3.1.1|MetaCyc: PWY-5041 TOPB45_0621 80b050cb49ca108cf53227db953e7aee 418 TIGRFAM TIGR00936 ahcY: adenosylhomocysteinase 3 418 8.9E-205 T 13-10-2018 IPR000043 Adenosylhomocysteinase-like KEGG: 00270+3.3.1.1|MetaCyc: PWY-5041 TOPB45_0621 80b050cb49ca108cf53227db953e7aee 418 Gene3D G3DSA:3.40.50.1480 5 407 2.1E-176 T 13-10-2018 TOPB45_0621 80b050cb49ca108cf53227db953e7aee 418 Pfam PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 185 345 1.6E-53 T 13-10-2018 IPR015878 S-adenosyl-L-homocysteine hydrolase, NAD binding domain KEGG: 00270+3.3.1.1|MetaCyc: PWY-5041 TOPB45_0621 80b050cb49ca108cf53227db953e7aee 418 SUPERFAMILY SSF52283 1 418 1.42E-99 T 13-10-2018 TOPB45_0621 80b050cb49ca108cf53227db953e7aee 418 ProSitePatterns PS00739 S-adenosyl-L-homocysteine hydrolase signature 2. 207 223 - T 13-10-2018 IPR020082 S-adenosyl-L-homocysteine hydrolase, conserved site GO:0004013 KEGG: 00270+3.3.1.1|MetaCyc: PWY-5041 TOPB45_0621 80b050cb49ca108cf53227db953e7aee 418 Hamap MF_00563 Adenosylhomocysteinase [ahcY]. 1 418 48.483 T 13-10-2018 IPR034373 Adenosylhomocysteinase GO:0004013|GO:0019510|GO:0051287 KEGG: 00270+3.3.1.1|MetaCyc: PWY-5041|Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-2408508|Reactome: R-HSA-5578997 TOPB45_0621 80b050cb49ca108cf53227db953e7aee 418 Pfam PF05221 S-adenosyl-L-homocysteine hydrolase 2 136 3.8E-36 T 13-10-2018 IPR000043 Adenosylhomocysteinase-like KEGG: 00270+3.3.1.1|MetaCyc: PWY-5041 TOPB45_0621 80b050cb49ca108cf53227db953e7aee 418 SUPERFAMILY SSF51735 185 347 2.11E-66 T 13-10-2018 IPR036291 NAD(P)-binding domain superfamily TOPB45_0621 80b050cb49ca108cf53227db953e7aee 418 SMART SM00996 2 417 1.3E-145 T 13-10-2018 IPR000043 Adenosylhomocysteinase-like KEGG: 00270+3.3.1.1|MetaCyc: PWY-5041 TOPB45_0621 80b050cb49ca108cf53227db953e7aee 418 PIRSF PIRSF001109 1 418 1.1E-188 T 13-10-2018 IPR000043 Adenosylhomocysteinase-like KEGG: 00270+3.3.1.1|MetaCyc: PWY-5041 TOPB45_0621 80b050cb49ca108cf53227db953e7aee 418 Pfam PF05221 S-adenosyl-L-homocysteine hydrolase 139 417 1.8E-28 T 13-10-2018 IPR000043 Adenosylhomocysteinase-like KEGG: 00270+3.3.1.1|MetaCyc: PWY-5041 TOPB45_0621 80b050cb49ca108cf53227db953e7aee 418 SMART SM00997 185 346 1.7E-105 T 13-10-2018 IPR015878 S-adenosyl-L-homocysteine hydrolase, NAD binding domain KEGG: 00270+3.3.1.1|MetaCyc: PWY-5041 TOPB45_0621 80b050cb49ca108cf53227db953e7aee 418 Gene3D G3DSA:3.40.50.720 187 346 2.1E-176 T 13-10-2018 TOPB45_0159 14202adfafa03c9224207905fb1756d7 306 SUPERFAMILY SSF55174 16 102 1.96E-9 T 13-10-2018 TOPB45_0159 14202adfafa03c9224207905fb1756d7 306 ProSitePatterns PS01129 Rlu family of pseudouridine synthase signature. 135 149 - T 13-10-2018 IPR006224 Pseudouridine synthase, RluC/RluD, conserved site GO:0001522|GO:0003723|GO:0009451|GO:0009982 TOPB45_0159 14202adfafa03c9224207905fb1756d7 306 Pfam PF00849 RNA pseudouridylate synthase 90 242 2.6E-32 T 13-10-2018 IPR006145 Pseudouridine synthase, RsuA/RluB/C/D/E/F GO:0001522|GO:0003723|GO:0009451|GO:0009982 TOPB45_0159 14202adfafa03c9224207905fb1756d7 306 SMART SM00363 16 73 1.5E-7 T 13-10-2018 IPR002942 RNA-binding S4 domain GO:0003723 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0159 14202adfafa03c9224207905fb1756d7 306 SUPERFAMILY SSF55120 74 303 5.35E-76 T 13-10-2018 IPR020103 Pseudouridine synthase, catalytic domain superfamily GO:0001522|GO:0003723|GO:0009451|GO:0009982 TOPB45_0159 14202adfafa03c9224207905fb1756d7 306 Gene3D G3DSA:3.30.2350.10 82 306 3.9E-76 T 13-10-2018 TOPB45_0159 14202adfafa03c9224207905fb1756d7 306 Pfam PF01479 S4 domain 17 62 6.8E-9 T 13-10-2018 IPR002942 RNA-binding S4 domain GO:0003723 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0159 14202adfafa03c9224207905fb1756d7 306 Gene3D G3DSA:3.10.290.10 4 71 1.1E-18 T 13-10-2018 IPR036986 RNA-binding S4 domain superfamily GO:0003723 TOPB45_0159 14202adfafa03c9224207905fb1756d7 306 TIGRFAM TIGR00005 rluA_subfam: pseudouridine synthase, RluA family 13 303 1.7E-90 T 13-10-2018 IPR006225 Pseudouridine synthase, RluC/RluD GO:0001522|GO:0003723|GO:0009451|GO:0009982 TOPB45_0690 79e19a367be3c807b44eeb8bfb3a5185 208 Pfam PF00117 Glutamine amidotransferase class-I 4 203 2.6E-20 T 13-10-2018 IPR017926 Glutamine amidotransferase TOPB45_0690 79e19a367be3c807b44eeb8bfb3a5185 208 TIGRFAM TIGR01855 IMP_synth_hisH: imidazole glycerol phosphate synthase, glutamine amidotransferase subunit 2 206 1.0E-66 T 13-10-2018 IPR010139 Imidazole glycerol phosphate synthase, subunit H GO:0000105|GO:0005737|GO:0016763 TOPB45_0690 79e19a367be3c807b44eeb8bfb3a5185 208 Gene3D G3DSA:3.40.50.880 1 207 3.6E-70 T 13-10-2018 IPR029062 Class I glutamine amidotransferase-like TOPB45_0690 79e19a367be3c807b44eeb8bfb3a5185 208 Hamap MF_00278 Imidazole glycerol phosphate synthase subunit HisH [hisH]. 1 206 34.396 T 13-10-2018 IPR010139 Imidazole glycerol phosphate synthase, subunit H GO:0000105|GO:0005737|GO:0016763 TOPB45_0690 79e19a367be3c807b44eeb8bfb3a5185 208 SUPERFAMILY SSF52317 2 206 1.16E-52 T 13-10-2018 IPR029062 Class I glutamine amidotransferase-like TOPB45_0690 79e19a367be3c807b44eeb8bfb3a5185 208 PIRSF PIRSF000495 1 208 8.6E-68 T 13-10-2018 IPR010139 Imidazole glycerol phosphate synthase, subunit H GO:0000105|GO:0005737|GO:0016763 TOPB45_1364 0bf9970235ca202cb06772f612938df9 599 Pfam PF01434 Peptidase family M41 388 593 9.2E-83 T 13-10-2018 IPR000642 Peptidase M41 GO:0004222|GO:0005524|GO:0006508 Reactome: R-HSA-8949664 TOPB45_1364 0bf9970235ca202cb06772f612938df9 599 Gene3D G3DSA:1.20.58.760 407 599 1.2E-79 T 13-10-2018 TOPB45_1364 0bf9970235ca202cb06772f612938df9 599 ProSitePatterns PS00674 AAA-protein family signature. 296 314 - T 13-10-2018 IPR003960 ATPase, AAA-type, conserved site GO:0005524 TOPB45_1364 0bf9970235ca202cb06772f612938df9 599 SMART SM00382 189 328 6.5E-26 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_1364 0bf9970235ca202cb06772f612938df9 599 Gene3D G3DSA:2.40.50.920 32 106 5.1E-13 T 13-10-2018 TOPB45_1364 0bf9970235ca202cb06772f612938df9 599 SUPERFAMILY SSF140990 407 598 4.32E-75 T 13-10-2018 IPR037219 Peptidase M41-like GO:0004222|GO:0005524|GO:0006508 Reactome: R-HSA-8949664 TOPB45_1364 0bf9970235ca202cb06772f612938df9 599 SUPERFAMILY SSF52540 153 420 7.08E-78 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1364 0bf9970235ca202cb06772f612938df9 599 Gene3D G3DSA:3.40.50.300 144 326 2.7E-73 T 13-10-2018 TOPB45_1364 0bf9970235ca202cb06772f612938df9 599 Pfam PF06480 FtsH Extracellular 10 99 4.4E-12 T 13-10-2018 IPR011546 Peptidase M41, FtsH extracellular GO:0004222|GO:0005524|GO:0008270|GO:0016021 Reactome: R-HSA-8949664 TOPB45_1364 0bf9970235ca202cb06772f612938df9 599 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 193 325 2.3E-45 T 13-10-2018 IPR003959 ATPase, AAA-type, core GO:0005524 TOPB45_1364 0bf9970235ca202cb06772f612938df9 599 Gene3D G3DSA:1.10.8.60 327 404 8.6E-26 T 13-10-2018 TOPB45_1364 0bf9970235ca202cb06772f612938df9 599 Hamap MF_01458 ATP-dependent zinc metalloprotease FtsH [ftsH]. 6 599 37.37 T 13-10-2018 IPR005936 Peptidase, FtsH GO:0004222|GO:0016020 Reactome: R-HSA-8949664 TOPB45_1364 0bf9970235ca202cb06772f612938df9 599 TIGRFAM TIGR01241 FtsH_fam: ATP-dependent metallopeptidase HflB 106 596 9.1E-234 T 13-10-2018 IPR005936 Peptidase, FtsH GO:0004222|GO:0016020 Reactome: R-HSA-8949664 TOPB45_0998 08bd7de0a5f40c05be2fd0389c91fb66 427 ProSitePatterns PS00184 Phosphoribosylglycinamide synthetase signature. 288 295 - T 13-10-2018 IPR020559 Phosphoribosylglycinamide synthetase, conserved site GO:0004637|GO:0009113 KEGG: 00230+6.3.4.13|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|Reactome: R-HSA-73817 TOPB45_0998 08bd7de0a5f40c05be2fd0389c91fb66 427 SUPERFAMILY SSF56059 103 313 3.03E-60 T 13-10-2018 TOPB45_0998 08bd7de0a5f40c05be2fd0389c91fb66 427 Gene3D G3DSA:3.30.1490.20 120 189 1.2E-29 T 13-10-2018 IPR013815 ATP-grasp fold, subdomain 1 GO:0005524 TOPB45_0998 08bd7de0a5f40c05be2fd0389c91fb66 427 Gene3D G3DSA:3.30.470.20 190 327 3.3E-55 T 13-10-2018 TOPB45_0998 08bd7de0a5f40c05be2fd0389c91fb66 427 SUPERFAMILY SSF51246 327 422 2.35E-30 T 13-10-2018 IPR011054 Rudiment single hybrid motif Reactome: R-HSA-196780 TOPB45_0998 08bd7de0a5f40c05be2fd0389c91fb66 427 Hamap MF_00138 Phosphoribosylamine--glycine ligase [purD]. 1 422 41.169 T 13-10-2018 IPR000115 Phosphoribosylglycinamide synthetase GO:0004637|GO:0009113 KEGG: 00230+6.3.4.13|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|Reactome: R-HSA-73817 TOPB45_0998 08bd7de0a5f40c05be2fd0389c91fb66 427 Pfam PF02844 Phosphoribosylglycinamide synthetase, N domain 1 101 6.0E-32 T 13-10-2018 IPR020562 Phosphoribosylglycinamide synthetase, N-terminal GO:0004637|GO:0009113 KEGG: 00230+6.3.4.13|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|Reactome: R-HSA-73817 TOPB45_0998 08bd7de0a5f40c05be2fd0389c91fb66 427 SMART SM01209 102 294 4.9E-130 T 13-10-2018 TOPB45_0998 08bd7de0a5f40c05be2fd0389c91fb66 427 Pfam PF02843 Phosphoribosylglycinamide synthetase, C domain 329 420 1.0E-30 T 13-10-2018 IPR020560 Phosphoribosylglycinamide synthetase, C-domain GO:0004637|GO:0009113 KEGG: 00230+6.3.4.13|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|Reactome: R-HSA-73817 TOPB45_0998 08bd7de0a5f40c05be2fd0389c91fb66 427 TIGRFAM TIGR00877 purD: phosphoribosylamine--glycine ligase 1 422 8.9E-170 T 13-10-2018 IPR000115 Phosphoribosylglycinamide synthetase GO:0004637|GO:0009113 KEGG: 00230+6.3.4.13|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|Reactome: R-HSA-73817 TOPB45_0998 08bd7de0a5f40c05be2fd0389c91fb66 427 SUPERFAMILY SSF52440 1 102 5.9E-32 T 13-10-2018 IPR016185 Pre-ATP-grasp domain superfamily TOPB45_0998 08bd7de0a5f40c05be2fd0389c91fb66 427 Gene3D G3DSA:3.90.600.10 328 427 8.8E-39 T 13-10-2018 IPR037123 Phosphoribosylglycinamide synthetase, C-domain superfamily GO:0004637|GO:0009113 KEGG: 00230+6.3.4.13|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|Reactome: R-HSA-73817 TOPB45_0998 08bd7de0a5f40c05be2fd0389c91fb66 427 Gene3D G3DSA:3.40.50.20 2 94 2.7E-34 T 13-10-2018 TOPB45_0998 08bd7de0a5f40c05be2fd0389c91fb66 427 Pfam PF01071 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain 102 294 7.9E-81 T 13-10-2018 IPR020561 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain KEGG: 00230+6.3.4.13|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|Reactome: R-HSA-73817 TOPB45_0998 08bd7de0a5f40c05be2fd0389c91fb66 427 SMART SM01210 328 422 5.8E-52 T 13-10-2018 IPR020560 Phosphoribosylglycinamide synthetase, C-domain GO:0004637|GO:0009113 KEGG: 00230+6.3.4.13|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|Reactome: R-HSA-73817 TOPB45_0307 656dbe135706569767d6265a4e510b64 380 Gene3D G3DSA:2.60.40.790 310 380 2.0E-15 T 13-10-2018 IPR008978 HSP20-like chaperone TOPB45_0307 656dbe135706569767d6265a4e510b64 380 TIGRFAM TIGR00345 GET3_arsA_TRC40: transport-energizing ATPase, TRC40/GET3/ArsA family 5 294 4.4E-73 T 13-10-2018 IPR016300 Arsenical pump ATPase, ArsA/GET3 GO:0005524|GO:0016887 Reactome: R-HSA-381038 TOPB45_0307 656dbe135706569767d6265a4e510b64 380 SUPERFAMILY SSF52540 1 289 1.53E-45 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0307 656dbe135706569767d6265a4e510b64 380 Gene3D G3DSA:3.40.50.300 1 309 5.8E-82 T 13-10-2018 TOPB45_0307 656dbe135706569767d6265a4e510b64 380 Pfam PF02374 Anion-transporting ATPase 1 296 1.9E-87 T 13-10-2018 IPR025723 Anion-transporting ATPase-like domain Reactome: R-HSA-381038 TOPB45_0584 5cb6c82d28f1e0ba61a855c875d3ff3c 290 SUPERFAMILY SSF53850 4 216 5.24E-58 T 13-10-2018 TOPB45_0584 5cb6c82d28f1e0ba61a855c875d3ff3c 290 Gene3D G3DSA:3.40.190.10 6 202 3.6E-58 T 13-10-2018 TOPB45_0584 5cb6c82d28f1e0ba61a855c875d3ff3c 290 Pfam PF08029 HisG, C-terminal domain 216 288 5.9E-25 T 13-10-2018 IPR013115 Histidine biosynthesis HisG, C-terminal GO:0000105|GO:0000287|GO:0003879|GO:0005737 KEGG: 00340+2.4.2.17 TOPB45_0584 5cb6c82d28f1e0ba61a855c875d3ff3c 290 Gene3D G3DSA:3.40.190.10 89 183 3.6E-58 T 13-10-2018 TOPB45_0584 5cb6c82d28f1e0ba61a855c875d3ff3c 290 Hamap MF_00079 ATP phosphoribosyltransferase [hisG]. 3 290 27.788 T 13-10-2018 IPR020621 ATP phosphoribosyltransferase HisG, long form GO:0000105|GO:0003879 KEGG: 00340+2.4.2.17 TOPB45_0584 5cb6c82d28f1e0ba61a855c875d3ff3c 290 ProSitePatterns PS01316 ATP phosphoribosyltransferase signature. 148 169 - T 13-10-2018 IPR018198 ATP phosphoribosyltransferase, conserved site GO:0003879 KEGG: 00340+2.4.2.17 TOPB45_0584 5cb6c82d28f1e0ba61a855c875d3ff3c 290 TIGRFAM TIGR03455 HisG_C-term: ATP phosphoribosyltransferase, C-terminal domain 190 290 1.5E-32 T 13-10-2018 IPR013115 Histidine biosynthesis HisG, C-terminal GO:0000105|GO:0000287|GO:0003879|GO:0005737 KEGG: 00340+2.4.2.17 TOPB45_0584 5cb6c82d28f1e0ba61a855c875d3ff3c 290 TIGRFAM TIGR00070 hisG: ATP phosphoribosyltransferase 4 189 1.1E-52 T 13-10-2018 IPR013820 ATP phosphoribosyltransferase, catalytic domain GO:0000105|GO:0003879|GO:0005737 KEGG: 00340+2.4.2.17 TOPB45_0584 5cb6c82d28f1e0ba61a855c875d3ff3c 290 Pfam PF01634 ATP phosphoribosyltransferase 50 212 6.7E-43 T 13-10-2018 IPR013820 ATP phosphoribosyltransferase, catalytic domain GO:0000105|GO:0003879|GO:0005737 KEGG: 00340+2.4.2.17 TOPB45_0584 5cb6c82d28f1e0ba61a855c875d3ff3c 290 SUPERFAMILY SSF54913 219 290 1.89E-20 T 13-10-2018 IPR011322 Nitrogen regulatory PII-like, alpha/beta TOPB45_0584 5cb6c82d28f1e0ba61a855c875d3ff3c 290 Gene3D G3DSA:3.30.70.120 219 290 2.9E-20 T 13-10-2018 IPR015867 Nitrogen regulatory protein PII/ATP phosphoribosyltransferase, C-terminal TOPB45_0267 7f98b0c19f2358d973d7ec8063292624 294 SUPERFAMILY SSF103481 200 292 4.05E-7 T 13-10-2018 TOPB45_0267 7f98b0c19f2358d973d7ec8063292624 294 SUPERFAMILY SSF103481 38 142 1.26E-11 T 13-10-2018 TOPB45_0267 7f98b0c19f2358d973d7ec8063292624 294 Pfam PF00892 EamA-like transporter family 157 291 1.1E-7 T 13-10-2018 IPR000620 EamA domain GO:0016020|GO:0016021 TOPB45_0267 7f98b0c19f2358d973d7ec8063292624 294 Pfam PF00892 EamA-like transporter family 2 138 9.5E-13 T 13-10-2018 IPR000620 EamA domain GO:0016020|GO:0016021 TOPB45_0861 500c4664a285fa95814f1ae820cd7530 297 TIGRFAM TIGR00277 HDIG: HDIG domain 118 223 2.6E-7 T 13-10-2018 IPR006675 HDIG domain TOPB45_0861 500c4664a285fa95814f1ae820cd7530 297 SMART SM00471 114 255 9.3E-5 T 13-10-2018 IPR003607 HD/PDEase domain TOPB45_0861 500c4664a285fa95814f1ae820cd7530 297 Gene3D G3DSA:1.10.3210.10 7 295 6.9E-51 T 13-10-2018 TOPB45_0861 500c4664a285fa95814f1ae820cd7530 297 Pfam PF08668 HDOD domain 37 224 2.1E-37 T 13-10-2018 IPR013976 Metal-dependent hydrolase HDOD TOPB45_0861 500c4664a285fa95814f1ae820cd7530 297 SUPERFAMILY SSF109604 32 288 1.37E-45 T 13-10-2018 TOPB45_1492 2b72610153bdfcd1235f7f035abb9bca 577 Pfam PF02085 Class III cytochrome C family 482 560 7.4E-6 T 13-10-2018 IPR020942 Class III cytochrome C GO:0009055|GO:0020037 TOPB45_1492 2b72610153bdfcd1235f7f035abb9bca 577 Pfam PF02085 Class III cytochrome C family 187 293 4.8E-5 T 13-10-2018 IPR020942 Class III cytochrome C GO:0009055|GO:0020037 TOPB45_1492 2b72610153bdfcd1235f7f035abb9bca 577 Pfam PF02085 Class III cytochrome C family 324 412 2.7E-11 T 13-10-2018 IPR020942 Class III cytochrome C GO:0009055|GO:0020037 TOPB45_1492 2b72610153bdfcd1235f7f035abb9bca 577 Pfam PF02085 Class III cytochrome C family 59 165 1.8E-7 T 13-10-2018 IPR020942 Class III cytochrome C GO:0009055|GO:0020037 TOPB45_1492 2b72610153bdfcd1235f7f035abb9bca 577 Gene3D G3DSA:3.90.10.10 385 563 1.2E-58 T 13-10-2018 TOPB45_1492 2b72610153bdfcd1235f7f035abb9bca 577 Gene3D G3DSA:3.90.10.10 36 173 7.1E-23 T 13-10-2018 TOPB45_1492 2b72610153bdfcd1235f7f035abb9bca 577 Gene3D G3DSA:3.90.10.10 320 439 1.2E-58 T 13-10-2018 TOPB45_1492 2b72610153bdfcd1235f7f035abb9bca 577 Gene3D G3DSA:3.90.10.10 176 300 6.2E-26 T 13-10-2018 TOPB45_1492 2b72610153bdfcd1235f7f035abb9bca 577 SUPERFAMILY SSF48695 46 562 5.89E-71 T 13-10-2018 IPR036280 Multiheme cytochrome superfamily TOPB45_0119 f26415703447aacfa927df4449bb2b55 108 TIGRFAM TIGR01068 thioredoxin: thioredoxin 7 105 1.8E-38 T 13-10-2018 IPR005746 Thioredoxin GO:0006662|GO:0015035|GO:0045454 TOPB45_0119 f26415703447aacfa927df4449bb2b55 108 ProSitePatterns PS00194 Thioredoxin family active site. 23 41 - T 13-10-2018 IPR017937 Thioredoxin, conserved site GO:0045454 TOPB45_0119 f26415703447aacfa927df4449bb2b55 108 PRINTS PR00421 Thioredoxin family signature 22 30 1.1E-9 T 13-10-2018 TOPB45_0119 f26415703447aacfa927df4449bb2b55 108 PRINTS PR00421 Thioredoxin family signature 30 39 1.1E-9 T 13-10-2018 TOPB45_0119 f26415703447aacfa927df4449bb2b55 108 PRINTS PR00421 Thioredoxin family signature 70 81 1.1E-9 T 13-10-2018 TOPB45_0119 f26415703447aacfa927df4449bb2b55 108 PIRSF PIRSF000077 1 106 1.2E-42 T 13-10-2018 IPR005746 Thioredoxin GO:0006662|GO:0015035|GO:0045454 TOPB45_0119 f26415703447aacfa927df4449bb2b55 108 Pfam PF00085 Thioredoxin 5 104 2.0E-33 T 13-10-2018 IPR013766 Thioredoxin domain GO:0045454 TOPB45_0119 f26415703447aacfa927df4449bb2b55 108 SUPERFAMILY SSF52833 5 107 2.81E-39 T 13-10-2018 IPR036249 Thioredoxin-like superfamily TOPB45_0119 f26415703447aacfa927df4449bb2b55 108 Gene3D G3DSA:3.40.30.10 4 108 1.8E-35 T 13-10-2018 TOPB45_0939 98e594ceb36f3e3879f507a8ee3e0d31 497 Hamap MF_00208 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase [murE]. 2 491 31.894 T 13-10-2018 IPR005761 UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase GO:0005524|GO:0005737|GO:0008360|GO:0016881|GO:0051301 TOPB45_0939 98e594ceb36f3e3879f507a8ee3e0d31 497 ProSitePatterns PS01011 Folylpolyglutamate synthase signature 1. 120 143 - T 13-10-2018 IPR018109 Folylpolyglutamate synthetase, conserved site GO:0004326|GO:0005524|GO:0009396 Reactome: R-HSA-196757 TOPB45_0939 98e594ceb36f3e3879f507a8ee3e0d31 497 Pfam PF01225 Mur ligase family, catalytic domain 34 108 2.7E-7 T 13-10-2018 IPR000713 Mur ligase, N-terminal catalytic domain GO:0005524|GO:0009058 TOPB45_0939 98e594ceb36f3e3879f507a8ee3e0d31 497 Pfam PF08245 Mur ligase middle domain 122 317 1.5E-41 T 13-10-2018 IPR013221 Mur ligase, central GO:0005524|GO:0009058 TOPB45_0939 98e594ceb36f3e3879f507a8ee3e0d31 497 Gene3D G3DSA:3.40.1190.10 113 342 5.9E-68 T 13-10-2018 IPR036565 Mur-like, catalytic domain superfamily GO:0005524|GO:0009058 Reactome: R-HSA-196757 TOPB45_0939 98e594ceb36f3e3879f507a8ee3e0d31 497 Pfam PF02875 Mur ligase family, glutamate ligase domain 341 423 3.2E-20 T 13-10-2018 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 TOPB45_0939 98e594ceb36f3e3879f507a8ee3e0d31 497 SUPERFAMILY SSF53623 113 336 5.23E-63 T 13-10-2018 IPR036565 Mur-like, catalytic domain superfamily GO:0005524|GO:0009058 Reactome: R-HSA-196757 TOPB45_0939 98e594ceb36f3e3879f507a8ee3e0d31 497 TIGRFAM TIGR01085 murE: UDP-N-acetylmuramyl-tripeptide synthetase 33 491 1.5E-152 T 13-10-2018 IPR005761 UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase GO:0005524|GO:0005737|GO:0008360|GO:0016881|GO:0051301 TOPB45_0939 98e594ceb36f3e3879f507a8ee3e0d31 497 Gene3D G3DSA:3.90.190.20 345 495 9.8E-60 T 13-10-2018 IPR036615 Mur ligase, C-terminal domain superfamily GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 TOPB45_0939 98e594ceb36f3e3879f507a8ee3e0d31 497 SUPERFAMILY SSF63418 31 111 6.28E-17 T 13-10-2018 IPR035911 MurE/MurF, N-terminal TOPB45_0939 98e594ceb36f3e3879f507a8ee3e0d31 497 SUPERFAMILY SSF53244 341 492 8.37E-46 T 13-10-2018 IPR036615 Mur ligase, C-terminal domain superfamily GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 TOPB45_0939 98e594ceb36f3e3879f507a8ee3e0d31 497 Gene3D G3DSA:3.40.1390.10 13 112 3.3E-19 T 13-10-2018 TOPB45_0144 87f2f5f2409b887bec19753f7c2755e5 219 Pfam PF04493 Endonuclease V 13 206 6.3E-67 T 13-10-2018 IPR007581 Endonuclease V GO:0004519|GO:0006281 TOPB45_0144 87f2f5f2409b887bec19753f7c2755e5 219 Hamap MF_00801 Endonuclease V [nfi]. 2 216 32.449 T 13-10-2018 IPR007581 Endonuclease V GO:0004519|GO:0006281 TOPB45_0144 87f2f5f2409b887bec19753f7c2755e5 219 Gene3D G3DSA:3.30.2170.10 1 217 7.5E-73 T 13-10-2018 TOPB45_0674 2b1f38d993fb0b26a513c384f72a217f 311 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 5 296 3.0E-31 T 13-10-2018 IPR020801 Polyketide synthase, acyl transferase domain TOPB45_0674 2b1f38d993fb0b26a513c384f72a217f 311 Gene3D G3DSA:3.40.366.10 5 280 4.6E-87 T 13-10-2018 IPR001227 Acyl transferase domain superfamily GO:0016740 TOPB45_0674 2b1f38d993fb0b26a513c384f72a217f 311 SUPERFAMILY SSF55048 130 196 3.79E-14 T 13-10-2018 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding TOPB45_0674 2b1f38d993fb0b26a513c384f72a217f 311 TIGRFAM TIGR00128 fabD: malonyl CoA-acyl carrier protein transacylase 1 288 6.0E-88 T 13-10-2018 IPR004410 Malonyl CoA-acyl carrier protein transacylase, FabD-type GO:0004314 KEGG: 00061+2.3.1.39|MetaCyc: PWY-4381|MetaCyc: PWY-6799|MetaCyc: PWY-7388 TOPB45_0674 2b1f38d993fb0b26a513c384f72a217f 311 Pfam PF00698 Acyl transferase domain 5 289 4.0E-32 T 13-10-2018 IPR014043 Acyl transferase TOPB45_0674 2b1f38d993fb0b26a513c384f72a217f 311 PIRSF PIRSF000446 1 310 5.3E-90 T 13-10-2018 IPR024925 Malonyl CoA-acyl carrier protein transacylase KEGG: 00061+2.3.1.39|MetaCyc: PWY-4381|MetaCyc: PWY-6799|MetaCyc: PWY-7388 TOPB45_0674 2b1f38d993fb0b26a513c384f72a217f 311 Gene3D G3DSA:3.30.70.250 129 195 4.6E-87 T 13-10-2018 TOPB45_0674 2b1f38d993fb0b26a513c384f72a217f 311 SUPERFAMILY SSF52151 1 308 6.02E-68 T 13-10-2018 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase TOPB45_1338 d7b908b3da23a4791eb81a0c932b4f85 171 Pfam PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 81 157 1.0E-18 T 13-10-2018 IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding GO:0003824|GO:0006281 Reactome: R-HSA-5657655 TOPB45_1338 d7b908b3da23a4791eb81a0c932b4f85 171 TIGRFAM TIGR00589 ogt: methylated-DNA--[protein]-cysteine S-methyltransferase 79 157 7.6E-25 T 13-10-2018 IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding GO:0003824|GO:0006281 Reactome: R-HSA-5657655 TOPB45_1338 d7b908b3da23a4791eb81a0c932b4f85 171 SUPERFAMILY SSF46767 79 159 6.93E-21 T 13-10-2018 IPR036217 Methylated DNA-protein cysteine methyltransferase, DNA binding domain Reactome: R-HSA-5657655 TOPB45_1338 d7b908b3da23a4791eb81a0c932b4f85 171 Gene3D G3DSA:1.10.10.10 77 164 2.6E-23 T 13-10-2018 IPR036388 Winged helix-like DNA-binding domain superfamily TOPB45_0997 44d0b125f823646eceebc1da6eae72d7 530 PRINTS PR01036 Tetracycline resistance protein TetB signature 407 426 6.7E-8 T 13-10-2018 TOPB45_0997 44d0b125f823646eceebc1da6eae72d7 530 PRINTS PR01036 Tetracycline resistance protein TetB signature 21 45 6.7E-8 T 13-10-2018 TOPB45_0997 44d0b125f823646eceebc1da6eae72d7 530 PRINTS PR01036 Tetracycline resistance protein TetB signature 112 132 6.7E-8 T 13-10-2018 TOPB45_0997 44d0b125f823646eceebc1da6eae72d7 530 PRINTS PR01036 Tetracycline resistance protein TetB signature 142 166 6.7E-8 T 13-10-2018 TOPB45_0997 44d0b125f823646eceebc1da6eae72d7 530 Gene3D G3DSA:1.20.1720.10 18 260 1.4E-40 T 13-10-2018 TOPB45_0997 44d0b125f823646eceebc1da6eae72d7 530 TIGRFAM TIGR00711 efflux_EmrB: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family 17 509 4.6E-124 T 13-10-2018 IPR004638 Drug resistance transporter EmrB/QacA subfamily GO:0016021|GO:0022857|GO:0055085 TOPB45_0997 44d0b125f823646eceebc1da6eae72d7 530 Pfam PF07690 Major Facilitator Superfamily 22 416 4.5E-44 T 13-10-2018 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TOPB45_0997 44d0b125f823646eceebc1da6eae72d7 530 SUPERFAMILY SSF103473 14 426 9.59E-50 T 13-10-2018 IPR036259 MFS transporter superfamily TOPB45_0997 44d0b125f823646eceebc1da6eae72d7 530 Gene3D G3DSA:1.20.1250.20 273 512 4.5E-12 T 13-10-2018 TOPB45_0592 782ece6d4ce97f78b03305874313e233 466 Pfam PF12631 MnmE helical domain 132 463 3.6E-52 T 13-10-2018 IPR025867 MnmE, helical domain Reactome: R-HSA-6787450 TOPB45_0592 782ece6d4ce97f78b03305874313e233 466 Gene3D G3DSA:3.30.1360.120 3 129 1.4E-45 T 13-10-2018 IPR027266 GTP-binding protein TrmE/Glycine cleavage system T protein, domain 1 GO:0005515 TOPB45_0592 782ece6d4ce97f78b03305874313e233 466 PRINTS PR00449 Transforming protein P21 ras signature 364 386 2.1E-6 T 13-10-2018 TOPB45_0592 782ece6d4ce97f78b03305874313e233 466 PRINTS PR00449 Transforming protein P21 ras signature 227 248 2.1E-6 T 13-10-2018 TOPB45_0592 782ece6d4ce97f78b03305874313e233 466 PRINTS PR00449 Transforming protein P21 ras signature 331 344 2.1E-6 T 13-10-2018 TOPB45_0592 782ece6d4ce97f78b03305874313e233 466 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 227 382 9.7E-28 T 13-10-2018 IPR005225 Small GTP-binding protein domain GO:0005525 TOPB45_0592 782ece6d4ce97f78b03305874313e233 466 Gene3D G3DSA:3.40.50.300 227 393 5.9E-106 T 13-10-2018 TOPB45_0592 782ece6d4ce97f78b03305874313e233 466 Pfam PF01926 50S ribosome-binding GTPase 230 341 1.8E-24 T 13-10-2018 IPR006073 GTP binding domain GO:0005525 TOPB45_0592 782ece6d4ce97f78b03305874313e233 466 Hamap MF_00379 tRNA modification GTPase MnmE [mnmE]. 9 466 33.676 T 13-10-2018 IPR004520 tRNA modification GTPase MnmE GO:0003924|GO:0005525|GO:0005622|GO:0006400 Reactome: R-HSA-6787450 TOPB45_0592 782ece6d4ce97f78b03305874313e233 466 TIGRFAM TIGR00450 mnmE_trmE_thdF: tRNA modification GTPase TrmE 15 466 1.9E-127 T 13-10-2018 IPR004520 tRNA modification GTPase MnmE GO:0003924|GO:0005525|GO:0005622|GO:0006400 Reactome: R-HSA-6787450 TOPB45_0592 782ece6d4ce97f78b03305874313e233 466 Gene3D G3DSA:1.20.120.430 130 466 5.9E-106 T 13-10-2018 IPR027368 tRNA modification GTPase MnmE domain 2 Reactome: R-HSA-6787450 TOPB45_0592 782ece6d4ce97f78b03305874313e233 466 SUPERFAMILY SSF52540 83 383 2.07E-41 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0592 782ece6d4ce97f78b03305874313e233 466 Pfam PF10396 GTP-binding protein TrmE N-terminus 10 129 1.5E-38 T 13-10-2018 IPR018948 GTP-binding protein TrmE, N-terminal Reactome: R-HSA-6787450 TOPB45_1576 456835b005d73199c6e12a84fd63d1bb 497 Hamap MF_00252 Lysine--tRNA ligase [lysS]. 10 494 43.683 T 13-10-2018 IPR002313 Lysine-tRNA ligase, class II GO:0004824|GO:0005524|GO:0006430 KEGG: 00970+6.1.1.6|Reactome: R-HSA-2408517|Reactome: R-HSA-379716|Reactome: R-HSA-379726 TOPB45_1576 456835b005d73199c6e12a84fd63d1bb 497 Pfam PF01336 OB-fold nucleic acid binding domain 59 136 1.3E-15 T 13-10-2018 IPR004365 OB-fold nucleic acid binding domain, AA-tRNA synthetase-type GO:0003676 TOPB45_1576 456835b005d73199c6e12a84fd63d1bb 497 SUPERFAMILY SSF50249 3 145 2.36E-40 T 13-10-2018 IPR012340 Nucleic acid-binding, OB-fold TOPB45_1576 456835b005d73199c6e12a84fd63d1bb 497 TIGRFAM TIGR00499 lysS_bact: lysine--tRNA ligase 5 494 9.2E-197 T 13-10-2018 IPR002313 Lysine-tRNA ligase, class II GO:0004824|GO:0005524|GO:0006430 KEGG: 00970+6.1.1.6|Reactome: R-HSA-2408517|Reactome: R-HSA-379716|Reactome: R-HSA-379726 TOPB45_1576 456835b005d73199c6e12a84fd63d1bb 497 Pfam PF00152 tRNA synthetases class II (D, K and N) 153 491 7.9E-79 T 13-10-2018 IPR004364 Aminoacyl-tRNA synthetase, class II (D/K/N) GO:0000166|GO:0004812|GO:0005524|GO:0006418 TOPB45_1576 456835b005d73199c6e12a84fd63d1bb 497 Gene3D G3DSA:3.30.930.10 148 497 3.0E-129 T 13-10-2018 TOPB45_1576 456835b005d73199c6e12a84fd63d1bb 497 SUPERFAMILY SSF55681 152 492 2.99E-115 T 13-10-2018 TOPB45_1576 456835b005d73199c6e12a84fd63d1bb 497 Gene3D G3DSA:2.40.50.140 1 147 1.2E-43 T 13-10-2018 TOPB45_1576 456835b005d73199c6e12a84fd63d1bb 497 PRINTS PR00982 Lysyl-tRNA synthetase signature 234 247 4.9E-38 T 13-10-2018 IPR018149 Lysyl-tRNA synthetase, class II, C-terminal GO:0000166|GO:0004824|GO:0005524|GO:0005737|GO:0006430 KEGG: 00970+6.1.1.6|Reactome: R-HSA-2408517|Reactome: R-HSA-379716|Reactome: R-HSA-379726 TOPB45_1576 456835b005d73199c6e12a84fd63d1bb 497 PRINTS PR00982 Lysyl-tRNA synthetase signature 205 221 4.9E-38 T 13-10-2018 IPR018149 Lysyl-tRNA synthetase, class II, C-terminal GO:0000166|GO:0004824|GO:0005524|GO:0005737|GO:0006430 KEGG: 00970+6.1.1.6|Reactome: R-HSA-2408517|Reactome: R-HSA-379716|Reactome: R-HSA-379726 TOPB45_1576 456835b005d73199c6e12a84fd63d1bb 497 PRINTS PR00982 Lysyl-tRNA synthetase signature 252 269 4.9E-38 T 13-10-2018 IPR018149 Lysyl-tRNA synthetase, class II, C-terminal GO:0000166|GO:0004824|GO:0005524|GO:0005737|GO:0006430 KEGG: 00970+6.1.1.6|Reactome: R-HSA-2408517|Reactome: R-HSA-379716|Reactome: R-HSA-379726 TOPB45_1576 456835b005d73199c6e12a84fd63d1bb 497 PRINTS PR00982 Lysyl-tRNA synthetase signature 189 199 4.9E-38 T 13-10-2018 IPR018149 Lysyl-tRNA synthetase, class II, C-terminal GO:0000166|GO:0004824|GO:0005524|GO:0005737|GO:0006430 KEGG: 00970+6.1.1.6|Reactome: R-HSA-2408517|Reactome: R-HSA-379716|Reactome: R-HSA-379726 TOPB45_1576 456835b005d73199c6e12a84fd63d1bb 497 PRINTS PR00982 Lysyl-tRNA synthetase signature 376 392 4.9E-38 T 13-10-2018 IPR018149 Lysyl-tRNA synthetase, class II, C-terminal GO:0000166|GO:0004824|GO:0005524|GO:0005737|GO:0006430 KEGG: 00970+6.1.1.6|Reactome: R-HSA-2408517|Reactome: R-HSA-379716|Reactome: R-HSA-379726 TOPB45_1469 bd9828a3234d877400e110ecd399733d 858 SMART SM01231 190 250 4.8E-16 T 13-10-2018 IPR004105 Histidine kinase CheA-like, homodimeric domain GO:0000155|GO:0000160|GO:0004673|GO:0005737|GO:0006935 TOPB45_1469 bd9828a3234d877400e110ecd399733d 858 SUPERFAMILY SSF52172 742 858 3.56E-33 T 13-10-2018 IPR011006 CheY-like superfamily TOPB45_1469 bd9828a3234d877400e110ecd399733d 858 SUPERFAMILY SSF50341 599 722 4.45E-16 T 13-10-2018 IPR036061 CheW-like domain superfamily GO:0006935|GO:0007165 TOPB45_1469 bd9828a3234d877400e110ecd399733d 858 Gene3D G3DSA:1.20.120.160 4 141 6.5E-34 T 13-10-2018 IPR036641 HPT domain superfamily GO:0000160 TOPB45_1469 bd9828a3234d877400e110ecd399733d 858 Pfam PF01627 Hpt domain 6 96 2.3E-13 T 13-10-2018 IPR008207 Signal transduction histidine kinase, phosphotransfer (Hpt) domain GO:0000160 TOPB45_1469 bd9828a3234d877400e110ecd399733d 858 SUPERFAMILY SSF47384 192 251 7.85E-14 T 13-10-2018 IPR036097 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily GO:0000155|GO:0007165 TOPB45_1469 bd9828a3234d877400e110ecd399733d 858 SMART SM00073 4 101 5.3E-22 T 13-10-2018 IPR008207 Signal transduction histidine kinase, phosphotransfer (Hpt) domain GO:0000160 TOPB45_1469 bd9828a3234d877400e110ecd399733d 858 PRINTS PR00344 Bacterial sensor protein C-terminal signature 398 416 3.8E-12 T 13-10-2018 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TOPB45_1469 bd9828a3234d877400e110ecd399733d 858 PRINTS PR00344 Bacterial sensor protein C-terminal signature 422 435 3.8E-12 T 13-10-2018 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TOPB45_1469 bd9828a3234d877400e110ecd399733d 858 PRINTS PR00344 Bacterial sensor protein C-terminal signature 340 354 3.8E-12 T 13-10-2018 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TOPB45_1469 bd9828a3234d877400e110ecd399733d 858 PRINTS PR00344 Bacterial sensor protein C-terminal signature 382 392 3.8E-12 T 13-10-2018 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TOPB45_1469 bd9828a3234d877400e110ecd399733d 858 Pfam PF00072 Response regulator receiver domain 743 853 1.5E-23 T 13-10-2018 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TOPB45_1469 bd9828a3234d877400e110ecd399733d 858 SUPERFAMILY SSF47226 3 113 5.1E-26 T 13-10-2018 IPR036641 HPT domain superfamily GO:0000160 TOPB45_1469 bd9828a3234d877400e110ecd399733d 858 Gene3D G3DSA:3.40.50.12740 740 858 2.1E-34 T 13-10-2018 TOPB45_1469 bd9828a3234d877400e110ecd399733d 858 Pfam PF01584 CheW-like domain 599 723 5.9E-11 T 13-10-2018 IPR002545 CheW-like domain GO:0006935|GO:0007165 TOPB45_1469 bd9828a3234d877400e110ecd399733d 858 Pfam PF01584 CheW-like domain 443 567 1.1E-22 T 13-10-2018 IPR002545 CheW-like domain GO:0006935|GO:0007165 TOPB45_1469 bd9828a3234d877400e110ecd399733d 858 Gene3D G3DSA:1.10.287.560 191 250 1.1E-18 T 13-10-2018 IPR037006 Histidine kinase CheA-like, homodimeric domain superfamily GO:0000155|GO:0006935 TOPB45_1469 bd9828a3234d877400e110ecd399733d 858 SMART SM00260 594 722 4.5E-5 T 13-10-2018 IPR002545 CheW-like domain GO:0006935|GO:0007165 TOPB45_1469 bd9828a3234d877400e110ecd399733d 858 SMART SM00260 430 568 1.2E-31 T 13-10-2018 IPR002545 CheW-like domain GO:0006935|GO:0007165 TOPB45_1469 bd9828a3234d877400e110ecd399733d 858 Gene3D G3DSA:2.30.30.40 438 564 9.5E-39 T 13-10-2018 TOPB45_1469 bd9828a3234d877400e110ecd399733d 858 SMART SM00387 295 438 1.4E-28 T 13-10-2018 IPR003594 Histidine kinase/HSP90-like ATPase TOPB45_1469 bd9828a3234d877400e110ecd399733d 858 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 298 437 1.2E-17 T 13-10-2018 IPR003594 Histidine kinase/HSP90-like ATPase TOPB45_1469 bd9828a3234d877400e110ecd399733d 858 SMART SM00448 741 853 1.9E-31 T 13-10-2018 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TOPB45_1469 bd9828a3234d877400e110ecd399733d 858 SUPERFAMILY SSF55874 253 436 1.7E-41 T 13-10-2018 IPR036890 Histidine kinase/HSP90-like ATPase superfamily TOPB45_1469 bd9828a3234d877400e110ecd399733d 858 Gene3D G3DSA:3.30.565.10 251 437 8.2E-60 T 13-10-2018 IPR036890 Histidine kinase/HSP90-like ATPase superfamily TOPB45_1469 bd9828a3234d877400e110ecd399733d 858 SUPERFAMILY SSF50341 437 567 1.31E-28 T 13-10-2018 IPR036061 CheW-like domain superfamily GO:0006935|GO:0007165 TOPB45_1469 bd9828a3234d877400e110ecd399733d 858 Pfam PF02895 Signal transducing histidine kinase, homodimeric domain 193 250 3.0E-13 T 13-10-2018 IPR004105 Histidine kinase CheA-like, homodimeric domain GO:0000155|GO:0000160|GO:0004673|GO:0005737|GO:0006935 TOPB45_1469 bd9828a3234d877400e110ecd399733d 858 Gene3D G3DSA:2.40.50.180 461 523 9.5E-39 T 13-10-2018 TOPB45_1469 bd9828a3234d877400e110ecd399733d 858 Gene3D G3DSA:2.40.50.180 619 679 2.4E-8 T 13-10-2018 TOPB45_0007 8cd9c19b5b18c58481272047fe2dc31a 112 TIGRFAM TIGR02532 IV_pilin_GFxxxE: prepilin-type N-terminal cleavage/methylation domain 5 26 7.9E-4 T 13-10-2018 IPR012902 Prokaryotic N-terminal methylation site TOPB45_0007 8cd9c19b5b18c58481272047fe2dc31a 112 Pfam PF07963 Prokaryotic N-terminal methylation motif 1 26 2.6E-6 T 13-10-2018 IPR012902 Prokaryotic N-terminal methylation site TOPB45_0007 8cd9c19b5b18c58481272047fe2dc31a 112 ProSitePatterns PS00409 Prokaryotic N-terminal methylation site. 5 25 - T 13-10-2018 IPR012902 Prokaryotic N-terminal methylation site TOPB45_1269 1482947bbd965c060d74ca5dcc09b7f4 91 Gene3D G3DSA:3.30.1200.10 1 90 1.8E-22 T 13-10-2018 IPR036591 YggU-like superfamily TOPB45_1269 1482947bbd965c060d74ca5dcc09b7f4 91 Hamap MF_00634 UPF0235 protein YggU [yggU]. 1 86 17.155 T 13-10-2018 IPR003746 Protein of unknown function DUF167 TOPB45_1269 1482947bbd965c060d74ca5dcc09b7f4 91 SUPERFAMILY SSF69786 2 83 2.35E-21 T 13-10-2018 IPR036591 YggU-like superfamily TOPB45_1269 1482947bbd965c060d74ca5dcc09b7f4 91 Pfam PF02594 Uncharacterised ACR, YggU family COG1872 2 73 1.7E-23 T 13-10-2018 IPR003746 Protein of unknown function DUF167 TOPB45_1269 1482947bbd965c060d74ca5dcc09b7f4 91 SMART SM01152 1 74 7.4E-20 T 13-10-2018 IPR003746 Protein of unknown function DUF167 TOPB45_0783 ef4bac550405dcd5b44b14ac69e10ff5 484 Gene3D G3DSA:1.10.3090.10 152 474 4.3E-39 T 13-10-2018 TOPB45_0783 ef4bac550405dcd5b44b14ac69e10ff5 484 Pfam PF01743 Poly A polymerase head domain 40 155 1.8E-11 T 13-10-2018 IPR002646 Poly A polymerase, head domain GO:0003723|GO:0006396|GO:0016779 Reactome: R-HSA-6784531|Reactome: R-HSA-6785470 TOPB45_0783 ef4bac550405dcd5b44b14ac69e10ff5 484 Pfam PF13735 tRNA nucleotidyltransferase domain 2 putative 411 472 1.6E-6 T 13-10-2018 IPR032810 CCA-adding enzyme, C-terminal TOPB45_0783 ef4bac550405dcd5b44b14ac69e10ff5 484 TIGRFAM TIGR00277 HDIG: HDIG domain 293 339 1.3E-7 T 13-10-2018 IPR006675 HDIG domain TOPB45_0783 ef4bac550405dcd5b44b14ac69e10ff5 484 Pfam PF12627 Probable RNA and SrmB- binding site of polymerase A 182 241 4.8E-13 T 13-10-2018 IPR032828 tRNA nucleotidyltransferase/poly(A) polymerase, RNA and SrmB- binding domain Reactome: R-HSA-6784531|Reactome: R-HSA-6785470 TOPB45_0783 ef4bac550405dcd5b44b14ac69e10ff5 484 SUPERFAMILY SSF81891 153 479 6.8E-44 T 13-10-2018 TOPB45_0783 ef4bac550405dcd5b44b14ac69e10ff5 484 Pfam PF01966 HD domain 257 395 4.8E-13 T 13-10-2018 IPR006674 HD domain TOPB45_0783 ef4bac550405dcd5b44b14ac69e10ff5 484 Gene3D G3DSA:3.30.460.10 10 150 1.1E-21 T 13-10-2018 TOPB45_0783 ef4bac550405dcd5b44b14ac69e10ff5 484 SUPERFAMILY SSF81301 35 151 1.63E-19 T 13-10-2018 TOPB45_0783 ef4bac550405dcd5b44b14ac69e10ff5 484 SMART SM00471 251 406 2.3E-4 T 13-10-2018 IPR003607 HD/PDEase domain TOPB45_1368 f8ba86639884f9a2b03226c0fd29c429 452 Gene3D G3DSA:3.40.120.10 2 152 2.4E-47 T 13-10-2018 TOPB45_1368 f8ba86639884f9a2b03226c0fd29c429 452 Pfam PF00408 Phosphoglucomutase/phosphomannomutase, C-terminal domain 378 446 5.9E-16 T 13-10-2018 IPR005843 Alpha-D-phosphohexomutase, C-terminal GO:0016868|GO:0071704 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TOPB45_1368 f8ba86639884f9a2b03226c0fd29c429 452 SUPERFAMILY SSF55957 362 451 5.49E-22 T 13-10-2018 IPR036900 Alpha-D-phosphohexomutase, C-terminal domain superfamily GO:0016868|GO:0071704 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TOPB45_1368 f8ba86639884f9a2b03226c0fd29c429 452 Hamap MF_01554_B Phosphoglucosamine mutase [glmM]. 2 449 45.603 T 13-10-2018 IPR006352 Phosphoglucosamine mutase, bacterial type GO:0000287|GO:0005975|GO:0008966 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TOPB45_1368 f8ba86639884f9a2b03226c0fd29c429 452 SUPERFAMILY SSF53738 262 368 1.96E-30 T 13-10-2018 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TOPB45_1368 f8ba86639884f9a2b03226c0fd29c429 452 Gene3D G3DSA:3.30.310.50 375 451 2.0E-24 T 13-10-2018 TOPB45_1368 f8ba86639884f9a2b03226c0fd29c429 452 TIGRFAM TIGR01455 glmM: phosphoglucosamine mutase 6 447 2.2E-178 T 13-10-2018 IPR006352 Phosphoglucosamine mutase, bacterial type GO:0000287|GO:0005975|GO:0008966 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TOPB45_1368 f8ba86639884f9a2b03226c0fd29c429 452 Pfam PF02879 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II 162 258 1.0E-17 T 13-10-2018 IPR005845 Alpha-D-phosphohexomutase, alpha/beta/alpha domain II GO:0005975 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TOPB45_1368 f8ba86639884f9a2b03226c0fd29c429 452 Gene3D G3DSA:3.40.120.10 261 344 3.4E-71 T 13-10-2018 TOPB45_1368 f8ba86639884f9a2b03226c0fd29c429 452 Pfam PF02880 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III 262 373 1.1E-30 T 13-10-2018 IPR005846 Alpha-D-phosphohexomutase, alpha/beta/alpha domain III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TOPB45_1368 f8ba86639884f9a2b03226c0fd29c429 452 SUPERFAMILY SSF53738 2 185 3.69E-46 T 13-10-2018 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TOPB45_1368 f8ba86639884f9a2b03226c0fd29c429 452 Gene3D G3DSA:3.40.120.10 178 367 3.4E-71 T 13-10-2018 TOPB45_1368 f8ba86639884f9a2b03226c0fd29c429 452 PRINTS PR00509 Phosphoglucomutase/phosphomannomutase family signature 96 110 1.5E-12 T 13-10-2018 IPR005841 Alpha-D-phosphohexomutase superfamily GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TOPB45_1368 f8ba86639884f9a2b03226c0fd29c429 452 PRINTS PR00509 Phosphoglucomutase/phosphomannomutase family signature 238 253 1.5E-12 T 13-10-2018 IPR005841 Alpha-D-phosphohexomutase superfamily GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TOPB45_1368 f8ba86639884f9a2b03226c0fd29c429 452 PRINTS PR00509 Phosphoglucomutase/phosphomannomutase family signature 178 197 1.5E-12 T 13-10-2018 IPR005841 Alpha-D-phosphohexomutase superfamily GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TOPB45_1368 f8ba86639884f9a2b03226c0fd29c429 452 SUPERFAMILY SSF53738 160 261 2.0E-28 T 13-10-2018 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TOPB45_1368 f8ba86639884f9a2b03226c0fd29c429 452 Pfam PF02878 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I 4 139 8.5E-44 T 13-10-2018 IPR005844 Alpha-D-phosphohexomutase, alpha/beta/alpha domain I GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TOPB45_1368 f8ba86639884f9a2b03226c0fd29c429 452 ProSitePatterns PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 97 106 - T 13-10-2018 IPR016066 Alpha-D-phosphohexomutase, conserved site GO:0000287 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TOPB45_1497 331a629acf360bf0bf47a72ffdf78adc 606 SMART SM00481 367 446 5.0E-16 T 13-10-2018 IPR003141 Polymerase/histidinol phosphatase, N-terminal TOPB45_1497 331a629acf360bf0bf47a72ffdf78adc 606 PIRSF PIRSF005047 31 601 1.2E-233 T 13-10-2018 IPR022311 Uncharacterised conserved protein UCP005047, YshC KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TOPB45_1497 331a629acf360bf0bf47a72ffdf78adc 606 Gene3D G3DSA:1.10.150.20 116 183 6.5E-23 T 13-10-2018 TOPB45_1497 331a629acf360bf0bf47a72ffdf78adc 606 Pfam PF14791 DNA polymerase beta thumb 283 343 2.9E-19 T 13-10-2018 IPR029398 DNA polymerase beta, thumb domain TOPB45_1497 331a629acf360bf0bf47a72ffdf78adc 606 Gene3D G3DSA:3.30.460.10 185 289 1.1E-32 T 13-10-2018 TOPB45_1497 331a629acf360bf0bf47a72ffdf78adc 606 Pfam PF02811 PHP domain 368 529 1.0E-10 T 13-10-2018 IPR004013 PHP domain GO:0003824 TOPB45_1497 331a629acf360bf0bf47a72ffdf78adc 606 Pfam PF14520 Helix-hairpin-helix domain 122 174 1.8E-8 T 13-10-2018 TOPB45_1497 331a629acf360bf0bf47a72ffdf78adc 606 Pfam PF14716 Helix-hairpin-helix domain 33 101 2.8E-23 T 13-10-2018 IPR010996 DNA polymerase beta-like, N-terminal domain TOPB45_1497 331a629acf360bf0bf47a72ffdf78adc 606 Gene3D G3DSA:3.30.210.10 290 354 6.8E-27 T 13-10-2018 IPR037160 DNA polymerase, thumb domain superfamily TOPB45_1497 331a629acf360bf0bf47a72ffdf78adc 606 SUPERFAMILY SSF47802 31 114 2.49E-21 T 13-10-2018 IPR027421 DNA polymerase lambda lyase domain superfamily TOPB45_1497 331a629acf360bf0bf47a72ffdf78adc 606 PRINTS PR00870 DNA-polymerase family X pol beta-like signature 325 342 1.1E-6 T 13-10-2018 IPR002008 DNA polymerase family X, beta-like GO:0003677|GO:0006281 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TOPB45_1497 331a629acf360bf0bf47a72ffdf78adc 606 PRINTS PR00870 DNA-polymerase family X pol beta-like signature 283 290 1.1E-6 T 13-10-2018 IPR002008 DNA polymerase family X, beta-like GO:0003677|GO:0006281 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TOPB45_1497 331a629acf360bf0bf47a72ffdf78adc 606 PRINTS PR00870 DNA-polymerase family X pol beta-like signature 88 105 1.1E-6 T 13-10-2018 IPR002008 DNA polymerase family X, beta-like GO:0003677|GO:0006281 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TOPB45_1497 331a629acf360bf0bf47a72ffdf78adc 606 SUPERFAMILY SSF89550 366 597 4.45E-51 T 13-10-2018 IPR016195 Polymerase/histidinol phosphatase-like GO:0003824 Reactome: R-HSA-6784531|Reactome: R-HSA-6791226 TOPB45_1497 331a629acf360bf0bf47a72ffdf78adc 606 SUPERFAMILY SSF81301 185 343 6.91E-44 T 13-10-2018 TOPB45_1497 331a629acf360bf0bf47a72ffdf78adc 606 SMART SM00483 31 343 1.4E-38 T 13-10-2018 IPR002054 DNA-directed DNA polymerase X GO:0003677|GO:0003887 TOPB45_1497 331a629acf360bf0bf47a72ffdf78adc 606 Gene3D G3DSA:1.10.150.110 31 115 1.1E-29 T 13-10-2018 IPR027421 DNA polymerase lambda lyase domain superfamily TOPB45_1497 331a629acf360bf0bf47a72ffdf78adc 606 Gene3D G3DSA:3.20.20.140 355 603 6.7E-74 T 13-10-2018 TOPB45_1497 331a629acf360bf0bf47a72ffdf78adc 606 SMART SM00278 156 175 280.0 T 13-10-2018 IPR003583 Helix-hairpin-helix DNA-binding motif, class 1 GO:0003677|GO:0006281 TOPB45_1497 331a629acf360bf0bf47a72ffdf78adc 606 SMART SM00278 121 140 400.0 T 13-10-2018 IPR003583 Helix-hairpin-helix DNA-binding motif, class 1 GO:0003677|GO:0006281 TOPB45_1497 331a629acf360bf0bf47a72ffdf78adc 606 SMART SM00278 81 100 19.0 T 13-10-2018 IPR003583 Helix-hairpin-helix DNA-binding motif, class 1 GO:0003677|GO:0006281 TOPB45_1616 da905799177d1b45419f3e18ccf2be4a 370 TIGRFAM TIGR00492 alr: alanine racemase 7 368 6.8E-108 T 13-10-2018 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 TOPB45_1616 da905799177d1b45419f3e18ccf2be4a 370 Gene3D G3DSA:3.20.20.10 11 223 2.0E-112 T 13-10-2018 IPR029066 PLP-binding barrel TOPB45_1616 da905799177d1b45419f3e18ccf2be4a 370 SUPERFAMILY SSF51419 9 242 1.06E-57 T 13-10-2018 IPR029066 PLP-binding barrel TOPB45_1616 da905799177d1b45419f3e18ccf2be4a 370 Gene3D G3DSA:2.40.37.10 7 367 2.0E-112 T 13-10-2018 IPR009006 Alanine racemase/group IV decarboxylase, C-terminal GO:0003824 TOPB45_1616 da905799177d1b45419f3e18ccf2be4a 370 SUPERFAMILY SSF50621 236 369 1.81E-41 T 13-10-2018 IPR009006 Alanine racemase/group IV decarboxylase, C-terminal GO:0003824 TOPB45_1616 da905799177d1b45419f3e18ccf2be4a 370 Pfam PF01168 Alanine racemase, N-terminal domain 9 228 2.6E-60 T 13-10-2018 IPR001608 Alanine racemase, N-terminal KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 TOPB45_1616 da905799177d1b45419f3e18ccf2be4a 370 Pfam PF00842 Alanine racemase, C-terminal domain 241 367 1.6E-39 T 13-10-2018 IPR011079 Alanine racemase, C-terminal KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 TOPB45_1616 da905799177d1b45419f3e18ccf2be4a 370 SMART SM01005 241 368 6.8E-53 T 13-10-2018 IPR011079 Alanine racemase, C-terminal KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 TOPB45_1616 da905799177d1b45419f3e18ccf2be4a 370 Hamap MF_01201 Alanine racemase. 2 368 30.694 T 13-10-2018 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 TOPB45_1616 da905799177d1b45419f3e18ccf2be4a 370 PRINTS PR00992 Alanine racemase signature 295 312 6.1E-46 T 13-10-2018 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 TOPB45_1616 da905799177d1b45419f3e18ccf2be4a 370 PRINTS PR00992 Alanine racemase signature 64 82 6.1E-46 T 13-10-2018 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 TOPB45_1616 da905799177d1b45419f3e18ccf2be4a 370 PRINTS PR00992 Alanine racemase signature 125 137 6.1E-46 T 13-10-2018 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 TOPB45_1616 da905799177d1b45419f3e18ccf2be4a 370 PRINTS PR00992 Alanine racemase signature 159 170 6.1E-46 T 13-10-2018 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 TOPB45_1616 da905799177d1b45419f3e18ccf2be4a 370 PRINTS PR00992 Alanine racemase signature 28 44 6.1E-46 T 13-10-2018 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 TOPB45_1616 da905799177d1b45419f3e18ccf2be4a 370 PRINTS PR00992 Alanine racemase signature 201 228 6.1E-46 T 13-10-2018 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 TOPB45_1616 da905799177d1b45419f3e18ccf2be4a 370 PRINTS PR00992 Alanine racemase signature 274 289 6.1E-46 T 13-10-2018 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 TOPB45_1616 da905799177d1b45419f3e18ccf2be4a 370 PRINTS PR00992 Alanine racemase signature 257 272 6.1E-46 T 13-10-2018 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 TOPB45_1616 da905799177d1b45419f3e18ccf2be4a 370 PRINTS PR00992 Alanine racemase signature 350 363 6.1E-46 T 13-10-2018 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 TOPB45_0155 2d534ba8fc8ecdc31cd67f3d684997b3 203 SUPERFAMILY SSF48452 92 184 1.8E-10 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_0155 2d534ba8fc8ecdc31cd67f3d684997b3 203 Pfam PF09976 Tetratricopeptide repeat-like domain 16 201 1.6E-10 T 13-10-2018 IPR018704 Tetratricopeptide repeat-like domain Reactome: R-HSA-192823|Reactome: R-HSA-381038|Reactome: R-HSA-381426|Reactome: R-HSA-6798695|Reactome: R-HSA-8957275 TOPB45_0155 2d534ba8fc8ecdc31cd67f3d684997b3 203 SMART SM00028 155 188 25.0 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_0155 2d534ba8fc8ecdc31cd67f3d684997b3 203 SMART SM00028 120 153 0.22 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_0155 2d534ba8fc8ecdc31cd67f3d684997b3 203 Gene3D G3DSA:1.25.40.10 12 198 8.8E-13 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_0298 4a1a95e06c0fd4ff4cf5b16e2109cd55 306 TIGRFAM TIGR00436 era: GTP-binding protein Era 12 282 4.6E-94 T 13-10-2018 IPR005662 GTP-binding protein Era GO:0003723|GO:0005525|GO:0005622 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0298 4a1a95e06c0fd4ff4cf5b16e2109cd55 306 Pfam PF01926 50S ribosome-binding GTPase 14 127 1.5E-26 T 13-10-2018 IPR006073 GTP binding domain GO:0005525 TOPB45_0298 4a1a95e06c0fd4ff4cf5b16e2109cd55 306 SUPERFAMILY SSF52540 14 210 4.18E-52 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0298 4a1a95e06c0fd4ff4cf5b16e2109cd55 306 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 14 34 2.5E-9 T 13-10-2018 IPR006073 GTP binding domain GO:0005525 TOPB45_0298 4a1a95e06c0fd4ff4cf5b16e2109cd55 306 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 81 99 2.5E-9 T 13-10-2018 IPR006073 GTP binding domain GO:0005525 TOPB45_0298 4a1a95e06c0fd4ff4cf5b16e2109cd55 306 Pfam PF07650 KH domain 210 288 1.6E-19 T 13-10-2018 IPR004044 K Homology domain, type 2 GO:0003723 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0298 4a1a95e06c0fd4ff4cf5b16e2109cd55 306 Gene3D G3DSA:3.30.300.20 187 299 4.4E-40 T 13-10-2018 IPR015946 K homology domain-like, alpha/beta TOPB45_0298 4a1a95e06c0fd4ff4cf5b16e2109cd55 306 Hamap MF_00367 GTPase Era [era]. 9 299 36.535 T 13-10-2018 IPR005662 GTP-binding protein Era GO:0003723|GO:0005525|GO:0005622 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0298 4a1a95e06c0fd4ff4cf5b16e2109cd55 306 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 10 170 3.9E-34 T 13-10-2018 IPR005225 Small GTP-binding protein domain GO:0005525 TOPB45_0298 4a1a95e06c0fd4ff4cf5b16e2109cd55 306 SUPERFAMILY SSF54814 185 296 2.03E-37 T 13-10-2018 IPR009019 K homology domain superfamily, prokaryotic type GO:0003723 TOPB45_0298 4a1a95e06c0fd4ff4cf5b16e2109cd55 306 Gene3D G3DSA:3.40.50.300 5 184 3.0E-52 T 13-10-2018 TOPB45_0054 86e16d9d2af67dbc958d82ac58e25984 328 PRINTS PR01590 FIS bacterial regulatory protein HTH signature 291 308 2.0E-8 T 13-10-2018 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 TOPB45_0054 86e16d9d2af67dbc958d82ac58e25984 328 PRINTS PR01590 FIS bacterial regulatory protein HTH signature 308 328 2.0E-8 T 13-10-2018 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 TOPB45_0054 86e16d9d2af67dbc958d82ac58e25984 328 ProSitePatterns PS00688 Sigma-54 interaction domain C-terminal part signature. 216 225 - T 13-10-2018 IPR025944 Sigma-54 interaction domain, conserved site TOPB45_0054 86e16d9d2af67dbc958d82ac58e25984 328 Gene3D G3DSA:3.40.50.300 4 173 3.9E-66 T 13-10-2018 TOPB45_0054 86e16d9d2af67dbc958d82ac58e25984 328 SUPERFAMILY SSF46689 216 327 1.79E-11 T 13-10-2018 IPR009057 Homeobox-like domain superfamily GO:0003677 TOPB45_0054 86e16d9d2af67dbc958d82ac58e25984 328 Pfam PF00158 Sigma-54 interaction domain 6 169 6.6E-69 T 13-10-2018 IPR002078 RNA polymerase sigma factor 54 interaction domain GO:0005524|GO:0006355|GO:0008134 TOPB45_0054 86e16d9d2af67dbc958d82ac58e25984 328 Gene3D G3DSA:1.10.8.60 174 252 9.4E-30 T 13-10-2018 TOPB45_0054 86e16d9d2af67dbc958d82ac58e25984 328 Pfam PF02954 Bacterial regulatory protein, Fis family 285 325 1.2E-9 T 13-10-2018 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 TOPB45_0054 86e16d9d2af67dbc958d82ac58e25984 328 Gene3D G3DSA:1.10.10.60 260 328 4.1E-11 T 13-10-2018 TOPB45_0054 86e16d9d2af67dbc958d82ac58e25984 328 SUPERFAMILY SSF52540 7 244 1.08E-74 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0054 86e16d9d2af67dbc958d82ac58e25984 328 SMART SM00382 24 173 9.8E-9 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_0054 86e16d9d2af67dbc958d82ac58e25984 328 ProSitePatterns PS00675 Sigma-54 interaction domain ATP-binding region A signature. 28 41 - T 13-10-2018 IPR025662 Sigma-54 interaction domain, ATP-binding site 1 TOPB45_1263 3a994f4be047cd28abae0a2cc3ce3787 508 Gene3D G3DSA:3.40.50.12780 1 404 1.0E-91 T 13-10-2018 TOPB45_1263 3a994f4be047cd28abae0a2cc3ce3787 508 Pfam PF00501 AMP-binding enzyme 10 409 1.3E-82 T 13-10-2018 IPR000873 AMP-dependent synthetase/ligase GO:0003824 TOPB45_1263 3a994f4be047cd28abae0a2cc3ce3787 508 SUPERFAMILY SSF56801 3 502 2.09E-115 T 13-10-2018 TOPB45_1263 3a994f4be047cd28abae0a2cc3ce3787 508 Pfam PF13193 AMP-binding enzyme C-terminal domain 427 490 7.5E-11 T 13-10-2018 IPR025110 AMP-binding enzyme, C-terminal domain TOPB45_1263 3a994f4be047cd28abae0a2cc3ce3787 508 Gene3D G3DSA:3.30.300.30 405 504 2.6E-18 T 13-10-2018 TOPB45_0741 ce98e9004d4978f4b985775e109dc780 304 Pfam PF01556 DnaJ C terminal domain 144 285 4.4E-21 T 13-10-2018 IPR002939 Chaperone DnaJ, C-terminal TOPB45_0741 ce98e9004d4978f4b985775e109dc780 304 Gene3D G3DSA:2.60.260.20 142 199 2.6E-9 T 13-10-2018 TOPB45_0741 ce98e9004d4978f4b985775e109dc780 304 Pfam PF00226 DnaJ domain 4 66 5.9E-32 T 13-10-2018 IPR001623 DnaJ domain TOPB45_0741 ce98e9004d4978f4b985775e109dc780 304 SUPERFAMILY SSF46565 3 103 4.58E-34 T 13-10-2018 IPR036869 Chaperone J-domain superfamily TOPB45_0741 ce98e9004d4978f4b985775e109dc780 304 Gene3D G3DSA:1.10.287.110 1 140 1.4E-36 T 13-10-2018 IPR036869 Chaperone J-domain superfamily TOPB45_0741 ce98e9004d4978f4b985775e109dc780 304 SMART SM00271 3 61 2.4E-37 T 13-10-2018 IPR001623 DnaJ domain TOPB45_0741 ce98e9004d4978f4b985775e109dc780 304 PRINTS PR00625 DnaJ domain signature 6 24 5.8E-30 T 13-10-2018 IPR001623 DnaJ domain TOPB45_0741 ce98e9004d4978f4b985775e109dc780 304 PRINTS PR00625 DnaJ domain signature 24 39 5.8E-30 T 13-10-2018 IPR001623 DnaJ domain TOPB45_0741 ce98e9004d4978f4b985775e109dc780 304 PRINTS PR00625 DnaJ domain signature 61 80 5.8E-30 T 13-10-2018 IPR001623 DnaJ domain TOPB45_0741 ce98e9004d4978f4b985775e109dc780 304 PRINTS PR00625 DnaJ domain signature 41 61 5.8E-30 T 13-10-2018 IPR001623 DnaJ domain TOPB45_0741 ce98e9004d4978f4b985775e109dc780 304 ProSitePatterns PS00636 Nt-dnaJ domain signature. 46 65 - T 13-10-2018 IPR018253 DnaJ domain, conserved site TOPB45_0741 ce98e9004d4978f4b985775e109dc780 304 Gene3D G3DSA:2.60.260.20 206 303 4.0E-22 T 13-10-2018 TOPB45_0741 ce98e9004d4978f4b985775e109dc780 304 SUPERFAMILY SSF49493 211 296 4.19E-20 T 13-10-2018 IPR008971 HSP40/DnaJ peptide-binding GO:0006457|GO:0051082 TOPB45_0042 4ac3accba238f67efb53bc47d01615c3 1756 ProSitePatterns PS00211 ABC transporters family signature. 798 812 - T 13-10-2018 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TOPB45_0042 4ac3accba238f67efb53bc47d01615c3 1756 Gene3D G3DSA:3.40.50.300 917 1024 7.7E-22 T 13-10-2018 TOPB45_0042 4ac3accba238f67efb53bc47d01615c3 1756 Gene3D G3DSA:3.30.190.20 1065 1177 2.4E-18 T 13-10-2018 TOPB45_0042 4ac3accba238f67efb53bc47d01615c3 1756 Gene3D G3DSA:3.40.50.300 1426 1748 2.2E-125 T 13-10-2018 TOPB45_0042 4ac3accba238f67efb53bc47d01615c3 1756 Gene3D G3DSA:1.10.8.280 279 376 1.2E-167 T 13-10-2018 TOPB45_0042 4ac3accba238f67efb53bc47d01615c3 1756 ProSitePatterns PS00211 ABC transporters family signature. 1299 1313 - T 13-10-2018 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TOPB45_0042 4ac3accba238f67efb53bc47d01615c3 1756 SUPERFAMILY SSF52540 586 877 2.11E-43 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0042 4ac3accba238f67efb53bc47d01615c3 1756 Gene3D G3DSA:3.40.50.300 1187 1413 1.2E-54 T 13-10-2018 TOPB45_0042 4ac3accba238f67efb53bc47d01615c3 1756 Gene3D G3DSA:1.20.1580.10 661 798 2.6E-113 T 13-10-2018 TOPB45_0042 4ac3accba238f67efb53bc47d01615c3 1756 TIGRFAM TIGR00630 uvra: excinuclease ABC subunit A 8 887 3.4E-250 T 13-10-2018 IPR004602 UvrABC system subunit A GO:0003677|GO:0006289|GO:0009380|GO:0016887 TOPB45_0042 4ac3accba238f67efb53bc47d01615c3 1756 Pfam PF00005 ABC transporter 1433 1674 2.2E-9 T 13-10-2018 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TOPB45_0042 4ac3accba238f67efb53bc47d01615c3 1756 SMART SM00382 603 874 0.26 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_0042 4ac3accba238f67efb53bc47d01615c3 1756 SMART SM00382 1442 1736 0.65 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_0042 4ac3accba238f67efb53bc47d01615c3 1756 Gene3D G3DSA:1.20.1580.10 90 464 1.2E-167 T 13-10-2018 TOPB45_0042 4ac3accba238f67efb53bc47d01615c3 1756 Pfam PF00005 ABC transporter 594 828 2.6E-9 T 13-10-2018 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TOPB45_0042 4ac3accba238f67efb53bc47d01615c3 1756 Gene3D G3DSA:3.30.190.20 130 236 1.2E-167 T 13-10-2018 TOPB45_0042 4ac3accba238f67efb53bc47d01615c3 1756 Gene3D G3DSA:1.20.1580.10 1506 1644 2.2E-125 T 13-10-2018 TOPB45_0042 4ac3accba238f67efb53bc47d01615c3 1756 SUPERFAMILY SSF52540 8 541 7.27E-32 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0042 4ac3accba238f67efb53bc47d01615c3 1756 SUPERFAMILY SSF52540 933 1381 5.63E-38 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0042 4ac3accba238f67efb53bc47d01615c3 1756 ProSitePatterns PS00211 ABC transporters family signature. 1644 1658 - T 13-10-2018 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TOPB45_0042 4ac3accba238f67efb53bc47d01615c3 1756 Gene3D G3DSA:3.40.50.300 8 566 1.2E-167 T 13-10-2018 TOPB45_0042 4ac3accba238f67efb53bc47d01615c3 1756 SUPERFAMILY SSF52540 1425 1723 1.25E-46 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0042 4ac3accba238f67efb53bc47d01615c3 1756 Gene3D G3DSA:3.40.50.300 584 906 2.6E-113 T 13-10-2018 TOPB45_0934 b77a46fa962a874cf8765bd95713ba5b 134 Gene3D G3DSA:1.10.10.10 20 133 7.8E-37 T 13-10-2018 IPR036388 Winged helix-like DNA-binding domain superfamily TOPB45_0934 b77a46fa962a874cf8765bd95713ba5b 134 SUPERFAMILY SSF46785 27 127 7.71E-24 T 13-10-2018 IPR036390 Winged helix DNA-binding domain superfamily TOPB45_0934 b77a46fa962a874cf8765bd95713ba5b 134 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 46 108 2.8E-13 T 13-10-2018 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TOPB45_0698 4229778b522f363ec465203ea8080371 349 Gene3D G3DSA:3.40.1780.10 21 348 2.0E-112 T 13-10-2018 TOPB45_0698 4229778b522f363ec465203ea8080371 349 SUPERFAMILY SSF111337 9 349 3.92E-116 T 13-10-2018 IPR036100 S-adenosylmethionine:tRNA ribosyltransferase-isomerase, QueA superfamily GO:0008616|GO:0016740|GO:0016853 MetaCyc: PWY-6700 TOPB45_0698 4229778b522f363ec465203ea8080371 349 Gene3D G3DSA:2.40.10.240 72 172 2.0E-112 T 13-10-2018 TOPB45_0698 4229778b522f363ec465203ea8080371 349 Hamap MF_00113 S-adenosylmethionine:tRNA ribosyltransferase-isomerase [queA]. 8 349 42.217 T 13-10-2018 IPR003699 S-adenosylmethionine:tRNA ribosyltransferase-isomerase, QueA GO:0008616|GO:0016740|GO:0016853 MetaCyc: PWY-6700 TOPB45_0698 4229778b522f363ec465203ea8080371 349 Pfam PF02547 Queuosine biosynthesis protein 11 348 1.7E-122 T 13-10-2018 IPR003699 S-adenosylmethionine:tRNA ribosyltransferase-isomerase, QueA GO:0008616|GO:0016740|GO:0016853 MetaCyc: PWY-6700 TOPB45_0698 4229778b522f363ec465203ea8080371 349 TIGRFAM TIGR00113 queA: S-adenosylmethionine:tRNA ribosyltransferase-isomerase 8 349 3.9E-118 T 13-10-2018 IPR003699 S-adenosylmethionine:tRNA ribosyltransferase-isomerase, QueA GO:0008616|GO:0016740|GO:0016853 MetaCyc: PWY-6700 TOPB45_0241 0a739e14c57c92e94e81bbc55d430b27 673 Gene3D G3DSA:3.30.70.1450 589 662 2.4E-19 T 13-10-2018 IPR036721 Regulator of K+ conductance, C-terminal domain superfamily GO:0006813 TOPB45_0241 0a739e14c57c92e94e81bbc55d430b27 673 Gene3D G3DSA:1.20.1530.20 3 382 9.5E-81 T 13-10-2018 IPR038770 Sodium/solute symporter superfamily TOPB45_0241 0a739e14c57c92e94e81bbc55d430b27 673 SUPERFAMILY SSF116726 586 656 3.01E-17 T 13-10-2018 IPR036721 Regulator of K+ conductance, C-terminal domain superfamily GO:0006813 TOPB45_0241 0a739e14c57c92e94e81bbc55d430b27 673 Gene3D G3DSA:3.40.50.720 410 573 4.4E-34 T 13-10-2018 TOPB45_0241 0a739e14c57c92e94e81bbc55d430b27 673 Pfam PF00999 Sodium/hydrogen exchanger family 11 374 1.6E-67 T 13-10-2018 IPR006153 Cation/H+ exchanger GO:0006812|GO:0015299|GO:0016021|GO:0055085 TOPB45_0241 0a739e14c57c92e94e81bbc55d430b27 673 Pfam PF02254 TrkA-N domain 416 528 3.6E-21 T 13-10-2018 IPR003148 Regulator of K+ conductance, N-terminal GO:0006813 TOPB45_0241 0a739e14c57c92e94e81bbc55d430b27 673 SUPERFAMILY SSF51735 413 544 6.4E-31 T 13-10-2018 IPR036291 NAD(P)-binding domain superfamily TOPB45_0241 0a739e14c57c92e94e81bbc55d430b27 673 Pfam PF02080 TrkA-C domain 593 656 3.3E-14 T 13-10-2018 IPR006037 Regulator of K+ conductance, C-terminal GO:0006813|GO:0008324 TOPB45_0378 6080fd991d7acc14343acf18f2648700 636 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 5 159 9.3E-15 T 13-10-2018 IPR005225 Small GTP-binding protein domain GO:0005525 TOPB45_0378 6080fd991d7acc14343acf18f2648700 636 Pfam PF02421 Ferrous iron transport protein B 7 162 1.3E-55 T 13-10-2018 IPR030389 FeoB-type guanine nucleotide-binding (G) domain GO:0005525 TOPB45_0378 6080fd991d7acc14343acf18f2648700 636 Gene3D G3DSA:3.40.50.300 7 204 6.6E-44 T 13-10-2018 TOPB45_0378 6080fd991d7acc14343acf18f2648700 636 Pfam PF07664 Ferrous iron transport protein B C terminus 421 467 6.8E-15 T 13-10-2018 IPR011640 Ferrous iron transport protein B, C-terminal GO:0015093|GO:0015684|GO:0016021 TOPB45_0378 6080fd991d7acc14343acf18f2648700 636 TIGRFAM TIGR00437 feoB: ferrous iron transport protein B 13 608 7.6E-166 T 13-10-2018 IPR003373 Ferrous iron transport protein B GO:0005525|GO:0015093|GO:0015684|GO:0016021 TOPB45_0378 6080fd991d7acc14343acf18f2648700 636 SUPERFAMILY SSF52540 7 186 6.65E-39 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0378 6080fd991d7acc14343acf18f2648700 636 Pfam PF07670 Nucleoside recognition 478 611 4.8E-25 T 13-10-2018 IPR011642 Nucleoside transporter/FeoB GTPase, Gate domain Reactome: R-HSA-83936 TOPB45_0378 6080fd991d7acc14343acf18f2648700 636 Pfam PF07670 Nucleoside recognition 318 409 4.9E-10 T 13-10-2018 IPR011642 Nucleoside transporter/FeoB GTPase, Gate domain Reactome: R-HSA-83936 TOPB45_0067 647fcb67b98f8532f2e8bb08b31504f4 270 PIRSF PIRSF001586 2 268 2.2E-79 T 13-10-2018 IPR010075 Phosphoribosylformylglycinamidine synthase subunit PurQ GO:0004642|GO:0005737|GO:0006189 KEGG: 00220+3.5.1.2|KEGG: 00230+6.3.5.3|KEGG: 00250+3.5.1.2|KEGG: 00471+3.5.1.2|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277 TOPB45_0067 647fcb67b98f8532f2e8bb08b31504f4 270 Gene3D G3DSA:3.40.50.880 1 266 6.5E-87 T 13-10-2018 IPR029062 Class I glutamine amidotransferase-like TOPB45_0067 647fcb67b98f8532f2e8bb08b31504f4 270 SMART SM01211 3 265 8.3E-117 T 13-10-2018 TOPB45_0067 647fcb67b98f8532f2e8bb08b31504f4 270 SUPERFAMILY SSF52317 1 265 1.29E-78 T 13-10-2018 IPR029062 Class I glutamine amidotransferase-like TOPB45_0067 647fcb67b98f8532f2e8bb08b31504f4 270 Pfam PF13507 CobB/CobQ-like glutamine amidotransferase domain 3 265 4.1E-90 T 13-10-2018 TOPB45_0663 d90902e803c24289555eade2ebe12284 333 Gene3D G3DSA:1.10.3730.40 182 332 4.3E-75 T 13-10-2018 TOPB45_0663 d90902e803c24289555eade2ebe12284 333 Pfam PF07991 Acetohydroxy acid isomeroreductase, NADPH-binding domain 13 177 4.2E-79 T 13-10-2018 IPR013116 Ketol-acid reductoisomerase, N-terminal KEGG: 00290+1.1.1.86|KEGG: 00770+1.1.1.86|MetaCyc: PWY-5103|MetaCyc: PWY-7111 TOPB45_0663 d90902e803c24289555eade2ebe12284 333 PIRSF PIRSF000116 2 205 1.2E-45 T 13-10-2018 IPR014359 Ketol-acid reductoisomerase, prokaryotic GO:0004455|GO:0009082|GO:0050661|GO:0055114 KEGG: 00290+1.1.1.86|KEGG: 00770+1.1.1.86|MetaCyc: PWY-5103|MetaCyc: PWY-7111 TOPB45_0663 d90902e803c24289555eade2ebe12284 333 PIRSF PIRSF000116 201 331 1.2E-16 T 13-10-2018 IPR014359 Ketol-acid reductoisomerase, prokaryotic GO:0004455|GO:0009082|GO:0050661|GO:0055114 KEGG: 00290+1.1.1.86|KEGG: 00770+1.1.1.86|MetaCyc: PWY-5103|MetaCyc: PWY-7111 TOPB45_0663 d90902e803c24289555eade2ebe12284 333 TIGRFAM TIGR00465 ilvC: ketol-acid reductoisomerase 14 327 2.3E-149 T 13-10-2018 IPR013023 Ketol-acid reductoisomerase GO:0009082|GO:0016491|GO:0055114 KEGG: 00290+1.1.1.86|KEGG: 00770+1.1.1.86|MetaCyc: PWY-5103|MetaCyc: PWY-7111 TOPB45_0663 d90902e803c24289555eade2ebe12284 333 Gene3D G3DSA:3.40.50.720 1 181 9.4E-82 T 13-10-2018 TOPB45_0663 d90902e803c24289555eade2ebe12284 333 SUPERFAMILY SSF51735 1 182 2.96E-77 T 13-10-2018 IPR036291 NAD(P)-binding domain superfamily TOPB45_0663 d90902e803c24289555eade2ebe12284 333 Pfam PF01450 Acetohydroxy acid isomeroreductase, catalytic domain 183 326 1.5E-70 T 13-10-2018 IPR000506 Ketol-acid reductoisomerase, C-terminal GO:0004455|GO:0009082|GO:0055114 KEGG: 00290+1.1.1.86|KEGG: 00770+1.1.1.86|MetaCyc: PWY-5103|MetaCyc: PWY-7111 TOPB45_0663 d90902e803c24289555eade2ebe12284 333 Hamap MF_00435 Ketol-acid reductoisomerase (NADP(+)) [ilvC]. 1 328 46.485 T 13-10-2018 IPR013023 Ketol-acid reductoisomerase GO:0009082|GO:0016491|GO:0055114 KEGG: 00290+1.1.1.86|KEGG: 00770+1.1.1.86|MetaCyc: PWY-5103|MetaCyc: PWY-7111 TOPB45_0663 d90902e803c24289555eade2ebe12284 333 SUPERFAMILY SSF48179 183 328 2.55E-74 T 13-10-2018 IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily GO:0055114 TOPB45_1102 c57c32df9fd0049698339ea280ecce47 89 Pfam PF04014 Antidote-toxin recognition MazE, bacterial antitoxin 12 52 2.4E-7 T 13-10-2018 IPR007159 SpoVT-AbrB domain GO:0003677 TOPB45_1102 c57c32df9fd0049698339ea280ecce47 89 Gene3D G3DSA:2.10.260.10 7 47 1.5E-9 T 13-10-2018 TOPB45_1102 c57c32df9fd0049698339ea280ecce47 89 SUPERFAMILY SSF89447 12 77 7.32E-10 T 13-10-2018 IPR037914 SpoVT-AbrB domain superfamily TOPB45_1102 c57c32df9fd0049698339ea280ecce47 89 TIGRFAM TIGR01439 lp_hng_hel_AbrB: transcriptional regulator, AbrB family 12 49 3.9E-10 T 13-10-2018 IPR007159 SpoVT-AbrB domain GO:0003677 TOPB45_1102 c57c32df9fd0049698339ea280ecce47 89 SMART SM00966 9 54 5.2E-9 T 13-10-2018 IPR007159 SpoVT-AbrB domain GO:0003677 TOPB45_0237 9d81db4ece368c238a1d4025dc4b7bcd 1175 Gene3D G3DSA:3.40.50.140 604 779 4.3E-29 T 13-10-2018 TOPB45_0237 9d81db4ece368c238a1d4025dc4b7bcd 1175 Pfam PF01751 Toprim domain 607 759 2.8E-20 T 13-10-2018 IPR006171 TOPRIM domain TOPB45_0237 9d81db4ece368c238a1d4025dc4b7bcd 1175 SMART SM00487 79 297 9.0E-24 T 13-10-2018 IPR014001 Helicase superfamily 1/2, ATP-binding domain TOPB45_0237 9d81db4ece368c238a1d4025dc4b7bcd 1175 SUPERFAMILY SSF52540 310 583 4.25E-17 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0237 9d81db4ece368c238a1d4025dc4b7bcd 1175 SMART SM00437 872 1122 6.4E-71 T 13-10-2018 IPR003602 DNA topoisomerase, type IA, DNA-binding domain GO:0003677|GO:0003916|GO:0006265 TOPB45_0237 9d81db4ece368c238a1d4025dc4b7bcd 1175 Gene3D G3DSA:2.60.510.20 831 1068 1.9E-132 T 13-10-2018 TOPB45_0237 9d81db4ece368c238a1d4025dc4b7bcd 1175 SMART SM00436 750 839 1.5E-38 T 13-10-2018 IPR003601 DNA topoisomerase, type IA, domain 2 GO:0003677|GO:0003916|GO:0006265 TOPB45_0237 9d81db4ece368c238a1d4025dc4b7bcd 1175 SUPERFAMILY SSF52540 5 277 2.61E-25 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0237 9d81db4ece368c238a1d4025dc4b7bcd 1175 Gene3D G3DSA:1.10.290.10 882 1005 1.9E-132 T 13-10-2018 IPR013826 DNA topoisomerase, type IA, central region, subdomain 3 TOPB45_0237 9d81db4ece368c238a1d4025dc4b7bcd 1175 TIGRFAM TIGR01054 rgy: reverse gyrase 7 1158 0.0 T 13-10-2018 IPR005736 Reverse gyrase GO:0003677|GO:0003916|GO:0006265 TOPB45_0237 9d81db4ece368c238a1d4025dc4b7bcd 1175 Gene3D G3DSA:1.10.460.10 780 1158 1.9E-132 T 13-10-2018 IPR013824 DNA topoisomerase, type IA, central region, subdomain 1 TOPB45_0237 9d81db4ece368c238a1d4025dc4b7bcd 1175 Pfam PF01131 DNA topoisomerase 774 1158 1.4E-79 T 13-10-2018 IPR013497 DNA topoisomerase, type IA, central GO:0003677|GO:0003916|GO:0006265 TOPB45_0237 9d81db4ece368c238a1d4025dc4b7bcd 1175 Hamap MF_01125 Reverse gyrase [rgy]. 1 1170 62.478 T 13-10-2018 IPR005736 Reverse gyrase GO:0003677|GO:0003916|GO:0006265 TOPB45_0237 9d81db4ece368c238a1d4025dc4b7bcd 1175 SUPERFAMILY SSF56712 603 1159 2.35E-123 T 13-10-2018 IPR023405 DNA topoisomerase, type IA, core domain TOPB45_0237 9d81db4ece368c238a1d4025dc4b7bcd 1175 SMART SM00493 605 749 1.1E-21 T 13-10-2018 IPR006171 TOPRIM domain TOPB45_0237 9d81db4ece368c238a1d4025dc4b7bcd 1175 Gene3D G3DSA:3.40.50.300 507 603 4.2E-11 T 13-10-2018 TOPB45_0237 9d81db4ece368c238a1d4025dc4b7bcd 1175 Gene3D G3DSA:3.40.50.300 290 496 1.9E-25 T 13-10-2018 TOPB45_0237 9d81db4ece368c238a1d4025dc4b7bcd 1175 PRINTS PR00417 Prokaryotic DNA topoisomerase I signature 1084 1098 7.7E-28 T 13-10-2018 IPR013497 DNA topoisomerase, type IA, central GO:0003677|GO:0003916|GO:0006265 TOPB45_0237 9d81db4ece368c238a1d4025dc4b7bcd 1175 PRINTS PR00417 Prokaryotic DNA topoisomerase I signature 914 923 7.7E-28 T 13-10-2018 IPR013497 DNA topoisomerase, type IA, central GO:0003677|GO:0003916|GO:0006265 TOPB45_0237 9d81db4ece368c238a1d4025dc4b7bcd 1175 PRINTS PR00417 Prokaryotic DNA topoisomerase I signature 809 827 7.7E-28 T 13-10-2018 IPR013497 DNA topoisomerase, type IA, central GO:0003677|GO:0003916|GO:0006265 TOPB45_0237 9d81db4ece368c238a1d4025dc4b7bcd 1175 PRINTS PR00417 Prokaryotic DNA topoisomerase I signature 723 736 7.7E-28 T 13-10-2018 IPR013497 DNA topoisomerase, type IA, central GO:0003677|GO:0003916|GO:0006265 TOPB45_0237 9d81db4ece368c238a1d4025dc4b7bcd 1175 PRINTS PR00417 Prokaryotic DNA topoisomerase I signature 994 1010 7.7E-28 T 13-10-2018 IPR013497 DNA topoisomerase, type IA, central GO:0003677|GO:0003916|GO:0006265 TOPB45_0237 9d81db4ece368c238a1d4025dc4b7bcd 1175 Gene3D G3DSA:3.40.50.300 62 287 2.1E-71 T 13-10-2018 TOPB45_0237 9d81db4ece368c238a1d4025dc4b7bcd 1175 Pfam PF00270 DEAD/DEAH box helicase 97 271 3.5E-13 T 13-10-2018 IPR011545 DEAD/DEAH box helicase domain GO:0003676|GO:0005524 TOPB45_0549 1cb57592c3c4373a757dd62b9e44ec21 333 SMART SM00382 35 166 7.1E-12 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_0549 1cb57592c3c4373a757dd62b9e44ec21 333 Gene3D G3DSA:1.10.10.10 247 318 6.0E-22 T 13-10-2018 IPR036388 Winged helix-like DNA-binding domain superfamily TOPB45_0549 1cb57592c3c4373a757dd62b9e44ec21 333 Pfam PF05491 Holliday junction DNA helicase ruvB C-terminus 243 316 3.8E-23 T 13-10-2018 IPR008823 DNA helicase, Holliday junction RuvB type, C-terminal GO:0003677|GO:0006281|GO:0006310|GO:0009378 TOPB45_0549 1cb57592c3c4373a757dd62b9e44ec21 333 SUPERFAMILY SSF52540 5 239 9.06E-49 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0549 1cb57592c3c4373a757dd62b9e44ec21 333 TIGRFAM TIGR00635 ruvB: Holliday junction DNA helicase RuvB 8 316 4.6E-105 T 13-10-2018 IPR004605 DNA helicase, Holliday junction RuvB type GO:0003677|GO:0005524|GO:0006281|GO:0006310|GO:0009378 TOPB45_0549 1cb57592c3c4373a757dd62b9e44ec21 333 Gene3D G3DSA:3.40.50.300 2 165 6.0E-41 T 13-10-2018 TOPB45_0549 1cb57592c3c4373a757dd62b9e44ec21 333 ProDom PD005323 DNA HELICASE HOLLIDAY JUNCTION RUVB NUCLEOTIDE-BINDING ATP-BINDING SOS RECOMBINATION RESPONSE 240 315 1.0E-13 T 13-10-2018 IPR008823 DNA helicase, Holliday junction RuvB type, C-terminal GO:0003677|GO:0006281|GO:0006310|GO:0009378 TOPB45_0549 1cb57592c3c4373a757dd62b9e44ec21 333 SUPERFAMILY SSF46785 247 317 2.94E-16 T 13-10-2018 IPR036390 Winged helix DNA-binding domain superfamily TOPB45_0549 1cb57592c3c4373a757dd62b9e44ec21 333 Gene3D G3DSA:1.10.8.60 166 246 2.7E-11 T 13-10-2018 TOPB45_0549 1cb57592c3c4373a757dd62b9e44ec21 333 Pfam PF05496 Holliday junction DNA helicase ruvB N-terminus 4 217 4.0E-82 T 13-10-2018 IPR008824 Holliday junction DNA helicase ruvB, N-terminal GO:0006281|GO:0006310|GO:0009378 TOPB45_0549 1cb57592c3c4373a757dd62b9e44ec21 333 Hamap MF_00016 Holliday junction ATP-dependent DNA helicase RuvB [ruvB]. 1 333 103.066 T 13-10-2018 IPR004605 DNA helicase, Holliday junction RuvB type GO:0003677|GO:0005524|GO:0006281|GO:0006310|GO:0009378 TOPB45_0897 deedb1bc62c3ad28aeef8847f00474ac 695 Gene3D G3DSA:3.30.2070.10 437 521 7.2E-120 T 13-10-2018 TOPB45_0897 deedb1bc62c3ad28aeef8847f00474ac 695 Pfam PF01568 Molydopterin dinucleotide binding domain 570 650 7.3E-16 T 13-10-2018 IPR006657 Molybdopterin dinucleotide-binding domain GO:0016491|GO:0043546|GO:0055114 TOPB45_0897 deedb1bc62c3ad28aeef8847f00474ac 695 Pfam PF04879 Molybdopterin oxidoreductase Fe4S4 domain 4 55 2.1E-11 T 13-10-2018 IPR006963 Molybdopterin oxidoreductase, 4Fe-4S domain GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_0897 deedb1bc62c3ad28aeef8847f00474ac 695 Gene3D G3DSA:3.40.228.10 135 547 7.2E-120 T 13-10-2018 TOPB45_0897 deedb1bc62c3ad28aeef8847f00474ac 695 Gene3D G3DSA:3.40.50.740 70 484 7.2E-120 T 13-10-2018 TOPB45_0897 deedb1bc62c3ad28aeef8847f00474ac 695 Gene3D G3DSA:2.40.40.20 555 695 8.1E-41 T 13-10-2018 TOPB45_0897 deedb1bc62c3ad28aeef8847f00474ac 695 SMART SM00926 2 56 1.9E-14 T 13-10-2018 IPR006963 Molybdopterin oxidoreductase, 4Fe-4S domain GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_0897 deedb1bc62c3ad28aeef8847f00474ac 695 Gene3D G3DSA:2.20.25.90 1 61 7.0E-16 T 13-10-2018 TOPB45_0897 deedb1bc62c3ad28aeef8847f00474ac 695 SUPERFAMILY SSF53706 3 577 8.64E-134 T 13-10-2018 TOPB45_0897 deedb1bc62c3ad28aeef8847f00474ac 695 Pfam PF00384 Molybdopterin oxidoreductase 62 480 9.1E-50 T 13-10-2018 IPR006656 Molybdopterin oxidoreductase GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_0897 deedb1bc62c3ad28aeef8847f00474ac 695 SUPERFAMILY SSF50692 531 680 1.56E-26 T 13-10-2018 IPR009010 Aspartate decarboxylase-like domain superfamily TOPB45_1303 39b35af8b937a6612417ca3a81ced14c 1022 Hamap MF_00420 Phosphoribosylformylglycinamidine synthase subunit PurL [purL]. 174 1022 198.661 T 13-10-2018 IPR010074 Phosphoribosylformylglycinamidine subunit PurL GO:0004642|GO:0005737|GO:0006189 KEGG: 00230+6.3.5.3|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277 TOPB45_1303 39b35af8b937a6612417ca3a81ced14c 1022 Gene3D G3DSA:3.30.1330.10 248 433 2.0E-50 T 13-10-2018 IPR036921 PurM-like, N-terminal domain superfamily TOPB45_1303 39b35af8b937a6612417ca3a81ced14c 1022 Gene3D G3DSA:3.90.650.10 846 1022 1.2E-41 T 13-10-2018 IPR036676 PurM-like, C-terminal domain superfamily TOPB45_1303 39b35af8b937a6612417ca3a81ced14c 1022 Gene3D G3DSA:3.90.650.10 436 618 2.3E-53 T 13-10-2018 IPR036676 PurM-like, C-terminal domain superfamily TOPB45_1303 39b35af8b937a6612417ca3a81ced14c 1022 SUPERFAMILY SSF55326 639 840 6.54E-42 T 13-10-2018 IPR036921 PurM-like, N-terminal domain superfamily TOPB45_1303 39b35af8b937a6612417ca3a81ced14c 1022 Pfam PF02769 AIR synthase related protein, C-terminal domain 851 991 8.1E-17 T 13-10-2018 IPR010918 PurM-like, C-terminal domain TOPB45_1303 39b35af8b937a6612417ca3a81ced14c 1022 Pfam PF02769 AIR synthase related protein, C-terminal domain 446 592 1.2E-24 T 13-10-2018 IPR010918 PurM-like, C-terminal domain TOPB45_1303 39b35af8b937a6612417ca3a81ced14c 1022 SUPERFAMILY SSF56042 848 1020 6.58E-39 T 13-10-2018 IPR036676 PurM-like, C-terminal domain superfamily TOPB45_1303 39b35af8b937a6612417ca3a81ced14c 1022 Pfam PF00586 AIR synthase related protein, N-terminal domain 319 429 1.0E-9 T 13-10-2018 IPR016188 PurM-like, N-terminal domain TOPB45_1303 39b35af8b937a6612417ca3a81ced14c 1022 SUPERFAMILY SSF56042 444 664 4.19E-50 T 13-10-2018 IPR036676 PurM-like, C-terminal domain superfamily TOPB45_1303 39b35af8b937a6612417ca3a81ced14c 1022 SUPERFAMILY SSF55326 237 431 9.77E-39 T 13-10-2018 IPR036921 PurM-like, N-terminal domain superfamily TOPB45_1303 39b35af8b937a6612417ca3a81ced14c 1022 Gene3D G3DSA:3.30.1330.10 625 840 5.1E-43 T 13-10-2018 IPR036921 PurM-like, N-terminal domain superfamily TOPB45_1303 39b35af8b937a6612417ca3a81ced14c 1022 SUPERFAMILY SSF82697 84 157 1.06E-6 T 13-10-2018 IPR036604 Phosphoribosylformylglycinamidine synthase subunit PurS-like superfamily KEGG: 00230+6.3.5.3|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|Reactome: R-HSA-73817 TOPB45_1303 39b35af8b937a6612417ca3a81ced14c 1022 SUPERFAMILY SSF82697 3 72 7.67E-6 T 13-10-2018 IPR036604 Phosphoribosylformylglycinamidine synthase subunit PurS-like superfamily KEGG: 00230+6.3.5.3|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|Reactome: R-HSA-73817 TOPB45_0392 b52b596da8b11ced51199d44f68be125 320 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 158 182 8.3E-14 T 13-10-2018 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TOPB45_0392 b52b596da8b11ced51199d44f68be125 320 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 122 130 8.3E-14 T 13-10-2018 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TOPB45_0392 b52b596da8b11ced51199d44f68be125 320 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 5 27 8.3E-14 T 13-10-2018 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TOPB45_0392 b52b596da8b11ced51199d44f68be125 320 SUPERFAMILY SSF51905 1 315 5.29E-35 T 13-10-2018 IPR036188 FAD/NAD(P)-binding domain superfamily TOPB45_0392 b52b596da8b11ced51199d44f68be125 320 Pfam PF13738 Pyridine nucleotide-disulphide oxidoreductase 8 290 1.3E-49 T 13-10-2018 TOPB45_0392 b52b596da8b11ced51199d44f68be125 320 Gene3D G3DSA:3.50.50.60 6 297 6.5E-57 T 13-10-2018 IPR036188 FAD/NAD(P)-binding domain superfamily TOPB45_0392 b52b596da8b11ced51199d44f68be125 320 Gene3D G3DSA:3.50.50.60 134 251 6.5E-57 T 13-10-2018 IPR036188 FAD/NAD(P)-binding domain superfamily TOPB45_0392 b52b596da8b11ced51199d44f68be125 320 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 162 180 1.1E-17 T 13-10-2018 TOPB45_0392 b52b596da8b11ced51199d44f68be125 320 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 6 25 1.1E-17 T 13-10-2018 TOPB45_0392 b52b596da8b11ced51199d44f68be125 320 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 271 293 1.1E-17 T 13-10-2018 TOPB45_1517 69f620bb636c4ba2783e6bd14093155a 476 ProSitePatterns PS01234 Glutamyl-tRNA(Gln) amidotransferase subunit B signature. 143 157 - T 13-10-2018 IPR017958 Glutamyl-tRNA(Gln) amidotransferase, subunit B, conserved site GO:0016884 TOPB45_1517 69f620bb636c4ba2783e6bd14093155a 476 Hamap MF_00121 Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B [gatB]. 2 475 38.348 T 13-10-2018 IPR004413 Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, B subunit GO:0016884 TOPB45_1517 69f620bb636c4ba2783e6bd14093155a 476 TIGRFAM TIGR00133 gatB: aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, B subunit 1 474 5.9E-185 T 13-10-2018 IPR004413 Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, B subunit GO:0016884 TOPB45_1517 69f620bb636c4ba2783e6bd14093155a 476 SUPERFAMILY SSF55931 4 295 2.42E-123 T 13-10-2018 IPR014746 Glutamine synthetase/guanido kinase, catalytic domain GO:0003824 TOPB45_1517 69f620bb636c4ba2783e6bd14093155a 476 Pfam PF02637 GatB domain 327 474 1.4E-49 T 13-10-2018 IPR018027 Asn/Gln amidotransferase GO:0016884 TOPB45_1517 69f620bb636c4ba2783e6bd14093155a 476 SMART SM00845 327 474 5.5E-71 T 13-10-2018 IPR018027 Asn/Gln amidotransferase GO:0016884 TOPB45_1517 69f620bb636c4ba2783e6bd14093155a 476 Gene3D G3DSA:1.10.10.410 415 476 1.1E-24 T 13-10-2018 IPR023168 Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, C-terminal TOPB45_1517 69f620bb636c4ba2783e6bd14093155a 476 SUPERFAMILY SSF89095 296 402 2.51E-29 T 13-10-2018 IPR003789 Aspartyl/glutamyl-tRNA amidotransferase subunit B-like GO:0016884 TOPB45_1517 69f620bb636c4ba2783e6bd14093155a 476 Pfam PF02934 GatB/GatE catalytic domain 5 288 3.2E-116 T 13-10-2018 IPR006075 Aspartyl/Glutamyl-tRNA(Gln) amidotransferase, subunit B/E, catalytic GO:0016874 TOPB45_1517 69f620bb636c4ba2783e6bd14093155a 476 Gene3D G3DSA:1.10.150.380 299 412 3.4E-35 T 13-10-2018 TOPB45_0484 e9445c47de8e0a42e2f466706f61e151 729 Pfam PF00982 Glycosyltransferase family 20 7 463 5.1E-153 T 13-10-2018 IPR001830 Glycosyl transferase, family 20 GO:0003824|GO:0005992 KEGG: 00500+2.4.1.15 TOPB45_0484 e9445c47de8e0a42e2f466706f61e151 729 SUPERFAMILY SSF56784 495 726 5.0E-41 T 13-10-2018 IPR036412 HAD-like superfamily TOPB45_0484 e9445c47de8e0a42e2f466706f61e151 729 Gene3D G3DSA:3.40.50.2000 27 459 5.5E-171 T 13-10-2018 TOPB45_0484 e9445c47de8e0a42e2f466706f61e151 729 Pfam PF02358 Trehalose-phosphatase 498 712 8.6E-49 T 13-10-2018 IPR003337 Trehalose-phosphatase GO:0003824|GO:0005992 TOPB45_0484 e9445c47de8e0a42e2f466706f61e151 729 TIGRFAM TIGR01484 HAD-SF-IIB: HAD hydrolase, family IIB 496 689 4.9E-27 T 13-10-2018 IPR006379 HAD-superfamily hydrolase, subfamily IIB Reactome: R-HSA-446205 TOPB45_0484 e9445c47de8e0a42e2f466706f61e151 729 Gene3D G3DSA:3.40.50.1000 497 711 1.5E-52 T 13-10-2018 IPR023214 HAD superfamily TOPB45_0484 e9445c47de8e0a42e2f466706f61e151 729 Gene3D G3DSA:3.30.70.1020 577 656 1.5E-52 T 13-10-2018 TOPB45_0484 e9445c47de8e0a42e2f466706f61e151 729 SUPERFAMILY SSF53756 7 465 2.39E-146 T 13-10-2018 TOPB45_0484 e9445c47de8e0a42e2f466706f61e151 729 Gene3D G3DSA:3.40.50.2000 241 448 5.5E-171 T 13-10-2018 TOPB45_0484 e9445c47de8e0a42e2f466706f61e151 729 TIGRFAM TIGR00685 T6PP: trehalose-phosphatase 494 718 6.0E-38 T 13-10-2018 IPR003337 Trehalose-phosphatase GO:0003824|GO:0005992 TOPB45_0907 0bf3a9122a44e9440b2e94d0a6d90902 602 Pfam PF14520 Helix-hairpin-helix domain 546 598 2.9E-9 T 13-10-2018 TOPB45_0907 0bf3a9122a44e9440b2e94d0a6d90902 602 SMART SM00465 12 93 1.2E-20 T 13-10-2018 IPR000305 GIY-YIG endonuclease TOPB45_0907 0bf3a9122a44e9440b2e94d0a6d90902 602 SUPERFAMILY SSF46600 186 239 1.31E-14 T 13-10-2018 IPR036876 UVR domain superfamily TOPB45_0907 0bf3a9122a44e9440b2e94d0a6d90902 602 Gene3D G3DSA:4.10.860.10 198 238 1.7E-8 T 13-10-2018 TOPB45_0907 0bf3a9122a44e9440b2e94d0a6d90902 602 Gene3D G3DSA:1.10.150.20 538 596 3.5E-15 T 13-10-2018 TOPB45_0907 0bf3a9122a44e9440b2e94d0a6d90902 602 Gene3D G3DSA:3.40.1440.10 1 97 2.9E-31 T 13-10-2018 IPR035901 GIY-YIG endonuclease superfamily Reactome: R-HSA-5693568|Reactome: R-HSA-6783310 TOPB45_0907 0bf3a9122a44e9440b2e94d0a6d90902 602 Hamap MF_00203 UvrABC system protein C [uvrC]. 1 595 25.594 T 13-10-2018 IPR004791 UvrABC system, subunit C GO:0006289|GO:0009380|GO:0009381 TOPB45_0907 0bf3a9122a44e9440b2e94d0a6d90902 602 Pfam PF02151 UvrB/uvrC motif 200 234 9.1E-11 T 13-10-2018 IPR001943 UVR domain GO:0005515 TOPB45_0907 0bf3a9122a44e9440b2e94d0a6d90902 602 TIGRFAM TIGR00194 uvrC: excinuclease ABC subunit C 5 576 9.9E-157 T 13-10-2018 IPR004791 UvrABC system, subunit C GO:0006289|GO:0009380|GO:0009381 TOPB45_0907 0bf3a9122a44e9440b2e94d0a6d90902 602 Gene3D G3DSA:3.30.420.340 373 537 4.0E-44 T 13-10-2018 IPR038476 UvrC homology region 2 superfamily TOPB45_0907 0bf3a9122a44e9440b2e94d0a6d90902 602 Pfam PF01541 GIY-YIG catalytic domain 14 88 2.2E-10 T 13-10-2018 IPR000305 GIY-YIG endonuclease TOPB45_0907 0bf3a9122a44e9440b2e94d0a6d90902 602 Pfam PF08459 UvrC Helix-hairpin-helix N-terminal 379 529 1.2E-40 T 13-10-2018 IPR001162 UvrC family homology region TOPB45_0907 0bf3a9122a44e9440b2e94d0a6d90902 602 SUPERFAMILY SSF47781 495 598 2.07E-16 T 13-10-2018 IPR010994 RuvA domain 2-like TOPB45_0907 0bf3a9122a44e9440b2e94d0a6d90902 602 SUPERFAMILY SSF82771 12 95 2.62E-21 T 13-10-2018 IPR035901 GIY-YIG endonuclease superfamily Reactome: R-HSA-5693568|Reactome: R-HSA-6783310 TOPB45_1091 ddff094ea0fbd434d1a129469b85163f 422 Gene3D G3DSA:3.40.50.300 169 329 5.5E-25 T 13-10-2018 TOPB45_1091 ddff094ea0fbd434d1a129469b85163f 422 SMART SM00382 203 331 2.2E-9 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_1091 ddff094ea0fbd434d1a129469b85163f 422 SUPERFAMILY SSF52540 195 346 1.26E-24 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1091 ddff094ea0fbd434d1a129469b85163f 422 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 208 328 2.1E-16 T 13-10-2018 IPR003959 ATPase, AAA-type, core GO:0005524 TOPB45_1154 ada0b84a8bebc98014ad26c87d3031a6 705 SMART SM00316 621 704 3.7E-12 T 13-10-2018 IPR022967 RNA-binding domain, S1 TOPB45_1154 ada0b84a8bebc98014ad26c87d3031a6 705 SMART SM00316 72 132 24.0 T 13-10-2018 IPR022967 RNA-binding domain, S1 TOPB45_1154 ada0b84a8bebc98014ad26c87d3031a6 705 Gene3D G3DSA:2.40.50.140 59 138 3.4E-19 T 13-10-2018 TOPB45_1154 ada0b84a8bebc98014ad26c87d3031a6 705 SUPERFAMILY SSF50249 621 698 4.4E-18 T 13-10-2018 IPR012340 Nucleic acid-binding, OB-fold TOPB45_1154 ada0b84a8bebc98014ad26c87d3031a6 705 Gene3D G3DSA:2.40.50.140 624 705 4.3E-18 T 13-10-2018 TOPB45_1154 ada0b84a8bebc98014ad26c87d3031a6 705 TIGRFAM TIGR02063 RNase_R: ribonuclease R 12 704 1.1E-243 T 13-10-2018 IPR011805 Ribonuclease R GO:0003723|GO:0004518 TOPB45_1154 ada0b84a8bebc98014ad26c87d3031a6 705 SMART SM00955 250 578 3.8E-167 T 13-10-2018 IPR001900 Ribonuclease II/R GO:0003723|GO:0004540 TOPB45_1154 ada0b84a8bebc98014ad26c87d3031a6 705 Pfam PF00773 RNB domain 250 578 3.4E-110 T 13-10-2018 IPR001900 Ribonuclease II/R GO:0003723|GO:0004540 TOPB45_1154 ada0b84a8bebc98014ad26c87d3031a6 705 Hamap MF_01895 Ribonuclease R [rnr]. 31 704 55.741 T 13-10-2018 IPR011805 Ribonuclease R GO:0003723|GO:0004518 TOPB45_1154 ada0b84a8bebc98014ad26c87d3031a6 705 SUPERFAMILY SSF50249 211 620 1.14E-141 T 13-10-2018 IPR012340 Nucleic acid-binding, OB-fold TOPB45_1154 ada0b84a8bebc98014ad26c87d3031a6 705 SUPERFAMILY SSF50249 60 137 5.05E-19 T 13-10-2018 IPR012340 Nucleic acid-binding, OB-fold TOPB45_1154 ada0b84a8bebc98014ad26c87d3031a6 705 Pfam PF00575 S1 RNA binding domain 619 702 1.3E-12 T 13-10-2018 IPR003029 S1 domain GO:0003676 TOPB45_1154 ada0b84a8bebc98014ad26c87d3031a6 705 SUPERFAMILY SSF50249 128 227 5.14E-16 T 13-10-2018 IPR012340 Nucleic acid-binding, OB-fold TOPB45_1154 ada0b84a8bebc98014ad26c87d3031a6 705 TIGRFAM TIGR00358 3_prime_RNase: VacB and RNase II family 3'-5' exoribonucleases 65 704 4.3E-192 T 13-10-2018 IPR004476 Ribonuclease II/ribonuclease R GO:0003723|GO:0004540|GO:0016070 TOPB45_1154 ada0b84a8bebc98014ad26c87d3031a6 705 Pfam PF08206 Ribonuclease B OB domain 79 134 1.5E-16 T 13-10-2018 IPR013223 Ribonuclease B, N-terminal OB domain TOPB45_1154 ada0b84a8bebc98014ad26c87d3031a6 705 SMART SM00357 78 135 1.3E-12 T 13-10-2018 IPR011129 Cold shock domain GO:0003676 TOPB45_0739 754ba563be08017a8b067a359efdaf0e 239 Pfam PF03358 NADPH-dependent FMN reductase 1 161 6.2E-30 T 13-10-2018 IPR005025 NADPH-dependent FMN reductase-like GO:0016491 TOPB45_0739 754ba563be08017a8b067a359efdaf0e 239 SUPERFAMILY SSF52218 1 190 4.19E-36 T 13-10-2018 IPR029039 Flavoprotein-like superfamily TOPB45_0739 754ba563be08017a8b067a359efdaf0e 239 Gene3D G3DSA:3.40.50.360 1 239 1.5E-39 T 13-10-2018 IPR029039 Flavoprotein-like superfamily TOPB45_0845 841f190801d35ef432c655fe04894b83 314 Pfam PF13177 DNA polymerase III, delta subunit 12 169 2.2E-53 T 13-10-2018 TOPB45_0845 841f190801d35ef432c655fe04894b83 314 Gene3D G3DSA:3.40.50.300 1 168 4.0E-57 T 13-10-2018 TOPB45_0845 841f190801d35ef432c655fe04894b83 314 SUPERFAMILY SSF52540 24 206 1.36E-46 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0845 841f190801d35ef432c655fe04894b83 314 TIGRFAM TIGR00678 holB: DNA polymerase III, delta' subunit 18 203 4.9E-61 T 13-10-2018 IPR004622 DNA polymerase III, delta prime subunit GO:0003887|GO:0006260|GO:0008408 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TOPB45_0031 3d0a3349f4b484b75f498d65ff0f8f95 152 TIGRFAM TIGR01750 fabZ: beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ 6 143 5.3E-54 T 13-10-2018 IPR010084 Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ GO:0005737|GO:0006633|GO:0016836 KEGG: 00061+4.2.1.59|KEGG: 00780+4.2.1.59|MetaCyc: PWY-5971|MetaCyc: PWY-5973|MetaCyc: PWY-5989|MetaCyc: PWY-5994|MetaCyc: PWY-6113|MetaCyc: PWY-6282|MetaCyc: PWY-6519|MetaCyc: PWY-7388|MetaCyc: PWY-7663|MetaCyc: PWY-7664|MetaCyc: PWY-7858|MetaCyc: PWYG-321 TOPB45_0031 3d0a3349f4b484b75f498d65ff0f8f95 152 Gene3D G3DSA:3.10.129.10 3 152 2.5E-56 T 13-10-2018 TOPB45_0031 3d0a3349f4b484b75f498d65ff0f8f95 152 SUPERFAMILY SSF54637 6 144 1.53E-44 T 13-10-2018 IPR029069 HotDog domain superfamily TOPB45_0031 3d0a3349f4b484b75f498d65ff0f8f95 152 Hamap MF_00406 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ [fabZ]. 6 147 33.344 T 13-10-2018 IPR010084 Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ GO:0005737|GO:0006633|GO:0016836 KEGG: 00061+4.2.1.59|KEGG: 00780+4.2.1.59|MetaCyc: PWY-5971|MetaCyc: PWY-5973|MetaCyc: PWY-5989|MetaCyc: PWY-5994|MetaCyc: PWY-6113|MetaCyc: PWY-6282|MetaCyc: PWY-6519|MetaCyc: PWY-7388|MetaCyc: PWY-7663|MetaCyc: PWY-7664|MetaCyc: PWY-7858|MetaCyc: PWYG-321 TOPB45_0031 3d0a3349f4b484b75f498d65ff0f8f95 152 Pfam PF07977 FabA-like domain 15 140 1.6E-34 T 13-10-2018 IPR013114 Beta-hydroxydecanoyl thiol ester dehydrase, FabA/FabZ KEGG: 00061+4.2.1.59|KEGG: 00780+4.2.1.59|MetaCyc: PWY-5971|MetaCyc: PWY-5973|MetaCyc: PWY-5989|MetaCyc: PWY-5994|MetaCyc: PWY-6113|MetaCyc: PWY-6282|MetaCyc: PWY-6519|MetaCyc: PWY-7388|MetaCyc: PWY-7663|MetaCyc: PWY-7664|MetaCyc: PWY-7858|MetaCyc: PWYG-321 TOPB45_0025 6c473393f1255a416828e151fe17786f 156 SUPERFAMILY SSF54534 83 155 6.54E-23 T 13-10-2018 TOPB45_0025 6c473393f1255a416828e151fe17786f 156 ProSitePatterns PS00830 Prokaryotic transcription elongation factors signature 2. 120 136 - T 13-10-2018 IPR018151 Transcription elongation factor, GreA/GreB, conserved site GO:0003677|GO:0032784 TOPB45_0025 6c473393f1255a416828e151fe17786f 156 Pfam PF03449 Transcription elongation factor, N-terminal 4 74 9.3E-30 T 13-10-2018 IPR022691 Transcription elongation factor, GreA/GreB, N-terminal GO:0003677|GO:0032784 TOPB45_0025 6c473393f1255a416828e151fe17786f 156 Gene3D G3DSA:3.10.50.30 78 156 1.3E-28 T 13-10-2018 IPR036953 Transcription elongation factor GreA/GreB, C-terminal domain superfamily GO:0003677|GO:0032784 TOPB45_0025 6c473393f1255a416828e151fe17786f 156 PIRSF PIRSF006092 1 156 1.7E-51 T 13-10-2018 IPR023459 Transcription elongation factor GreA/GreB family GO:0070063 TOPB45_0025 6c473393f1255a416828e151fe17786f 156 SUPERFAMILY SSF46557 3 76 1.31E-26 T 13-10-2018 IPR036805 Transcription elongation factor, GreA/GreB, N-terminal domain superfamily GO:0003677|GO:0032784 TOPB45_0025 6c473393f1255a416828e151fe17786f 156 TIGRFAM TIGR01462 greA: transcription elongation factor GreA 6 155 1.4E-55 T 13-10-2018 IPR006359 Transcription elongation factor GreA GO:0003677|GO:0032784 TOPB45_0025 6c473393f1255a416828e151fe17786f 156 Gene3D G3DSA:1.10.287.180 1 75 1.9E-30 T 13-10-2018 IPR036805 Transcription elongation factor, GreA/GreB, N-terminal domain superfamily GO:0003677|GO:0032784 TOPB45_0025 6c473393f1255a416828e151fe17786f 156 Hamap MF_00105 Transcription elongation factor GreA [greA]. 2 155 30.909 T 13-10-2018 IPR028624 Transcription elongation factor GreA/GreB GO:0003677|GO:0032784|GO:0070063 TOPB45_0025 6c473393f1255a416828e151fe17786f 156 ProSitePatterns PS00829 Prokaryotic transcription elongation factors signature 1. 17 48 - T 13-10-2018 IPR018151 Transcription elongation factor, GreA/GreB, conserved site GO:0003677|GO:0032784 TOPB45_0025 6c473393f1255a416828e151fe17786f 156 Pfam PF01272 Transcription elongation factor, GreA/GreB, C-term 83 155 1.2E-27 T 13-10-2018 IPR001437 Transcription elongation factor, GreA/GreB, C-terminal GO:0003677|GO:0032784 TOPB45_0536 9554c7c7cfbbbac78e59e862459fb619 397 SMART SM00849 33 225 1.6E-25 T 13-10-2018 IPR001279 Metallo-beta-lactamase TOPB45_0536 9554c7c7cfbbbac78e59e862459fb619 397 Pfam PF00258 Flavodoxin 254 384 4.4E-12 T 13-10-2018 IPR008254 Flavodoxin/nitric oxide synthase GO:0010181 TOPB45_0536 9554c7c7cfbbbac78e59e862459fb619 397 SUPERFAMILY SSF52218 249 394 5.48E-40 T 13-10-2018 IPR029039 Flavoprotein-like superfamily TOPB45_0536 9554c7c7cfbbbac78e59e862459fb619 397 Gene3D G3DSA:3.40.50.360 247 397 1.8E-43 T 13-10-2018 IPR029039 Flavoprotein-like superfamily TOPB45_0536 9554c7c7cfbbbac78e59e862459fb619 397 SUPERFAMILY SSF56281 11 280 1.49E-46 T 13-10-2018 IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like TOPB45_0536 9554c7c7cfbbbac78e59e862459fb619 397 Gene3D G3DSA:3.60.15.10 1 245 4.8E-96 T 13-10-2018 IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like TOPB45_0536 9554c7c7cfbbbac78e59e862459fb619 397 PIRSF PIRSF005243 1 397 4.2E-152 T 13-10-2018 IPR016440 Rubredoxin-oxygen oxidoreductase GO:0009055|GO:0010181|GO:0016491|GO:0046872 TOPB45_0530 be96389da9b365d46b4e47054fff53c0 256 TIGRFAM TIGR00087 surE: 5'/3'-nucleotidase SurE 1 235 7.3E-65 T 13-10-2018 IPR002828 Survival protein SurE-like phosphatase/nucleotidase GO:0016787 KEGG: 00230+3.1.3.5|KEGG: 00240+3.1.3.5|KEGG: 00760+3.1.3.5|MetaCyc: PWY-5381|MetaCyc: PWY-5695|MetaCyc: PWY-6596|MetaCyc: PWY-6606|MetaCyc: PWY-6607|MetaCyc: PWY-6608|MetaCyc: PWY-7185|MetaCyc: PWY-7821 TOPB45_0530 be96389da9b365d46b4e47054fff53c0 256 Hamap MF_00060 5'/3'-nucleotidase SurE [surE]. 1 252 33.894 T 13-10-2018 IPR030048 Survival protein SurE GO:0008252 KEGG: 00230+3.1.3.5|KEGG: 00240+3.1.3.5|KEGG: 00760+3.1.3.5|MetaCyc: PWY-5381|MetaCyc: PWY-5695|MetaCyc: PWY-6596|MetaCyc: PWY-6606|MetaCyc: PWY-6607|MetaCyc: PWY-6608|MetaCyc: PWY-7185|MetaCyc: PWY-7821 TOPB45_0530 be96389da9b365d46b4e47054fff53c0 256 Gene3D G3DSA:3.40.1210.10 1 252 1.4E-80 T 13-10-2018 IPR036523 SurE-like phosphatase/nucleotidase superfamily GO:0016787 KEGG: 00230+3.1.3.5|KEGG: 00240+3.1.3.5|KEGG: 00760+3.1.3.5|MetaCyc: PWY-5381|MetaCyc: PWY-5695|MetaCyc: PWY-6596|MetaCyc: PWY-6606|MetaCyc: PWY-6607|MetaCyc: PWY-6608|MetaCyc: PWY-7185|MetaCyc: PWY-7821 TOPB45_0530 be96389da9b365d46b4e47054fff53c0 256 SUPERFAMILY SSF64167 1 250 2.35E-78 T 13-10-2018 TOPB45_0530 be96389da9b365d46b4e47054fff53c0 256 Pfam PF01975 Survival protein SurE 3 183 1.0E-54 T 13-10-2018 IPR002828 Survival protein SurE-like phosphatase/nucleotidase GO:0016787 KEGG: 00230+3.1.3.5|KEGG: 00240+3.1.3.5|KEGG: 00760+3.1.3.5|MetaCyc: PWY-5381|MetaCyc: PWY-5695|MetaCyc: PWY-6596|MetaCyc: PWY-6606|MetaCyc: PWY-6607|MetaCyc: PWY-6608|MetaCyc: PWY-7185|MetaCyc: PWY-7821 TOPB45_0693 8df26bd089267a29fe9de2ae0a9cdb6b 316 Gene3D G3DSA:3.20.20.70 18 311 2.4E-27 T 13-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 TOPB45_0693 8df26bd089267a29fe9de2ae0a9cdb6b 316 SMART SM00729 19 234 0.0035 T 13-10-2018 IPR006638 Elp3/MiaB/NifB GO:0003824|GO:0051536 TOPB45_0693 8df26bd089267a29fe9de2ae0a9cdb6b 316 Pfam PF04055 Radical SAM superfamily 29 188 5.1E-20 T 13-10-2018 IPR007197 Radical SAM GO:0003824|GO:0051536 TOPB45_0693 8df26bd089267a29fe9de2ae0a9cdb6b 316 SUPERFAMILY SSF102114 27 232 2.88E-26 T 13-10-2018 TOPB45_0018 a4d49b6bc0f1c326fb8177f8c4a9e111 366 Pfam PF03739 Predicted permease YjgP/YjgQ family 6 350 1.4E-48 T 13-10-2018 IPR005495 Permease LptG/LptF-related GO:0016021 TOPB45_0793 2b005d319dfe62166c2baea10c625564 866 SUPERFAMILY SSF56672 452 866 4.0E-147 T 13-10-2018 TOPB45_0793 2b005d319dfe62166c2baea10c625564 866 Gene3D G3DSA:1.10.150.20 181 254 6.6E-89 T 13-10-2018 TOPB45_0793 2b005d319dfe62166c2baea10c625564 866 SUPERFAMILY SSF47807 179 294 1.0E-27 T 13-10-2018 IPR036279 5'-3' exonuclease, C-terminal domain superfamily TOPB45_0793 2b005d319dfe62166c2baea10c625564 866 SUPERFAMILY SSF88723 12 168 1.82E-46 T 13-10-2018 IPR029060 PIN-like domain superfamily TOPB45_0793 2b005d319dfe62166c2baea10c625564 866 Gene3D G3DSA:1.10.150.20 640 783 1.0E-108 T 13-10-2018 TOPB45_0793 2b005d319dfe62166c2baea10c625564 866 SUPERFAMILY SSF53098 327 470 1.4E-11 T 13-10-2018 IPR012337 Ribonuclease H-like superfamily TOPB45_0793 2b005d319dfe62166c2baea10c625564 866 SMART SM00482 617 823 1.7E-110 T 13-10-2018 IPR001098 DNA-directed DNA polymerase, family A, palm domain GO:0003677|GO:0003887|GO:0006260 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TOPB45_0793 2b005d319dfe62166c2baea10c625564 866 Pfam PF00476 DNA polymerase family A 480 864 6.3E-151 T 13-10-2018 IPR001098 DNA-directed DNA polymerase, family A, palm domain GO:0003677|GO:0003887|GO:0006260 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TOPB45_0793 2b005d319dfe62166c2baea10c625564 866 PRINTS PR00868 DNA-polymerase family A (pol I) signature 661 674 1.0E-77 T 13-10-2018 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TOPB45_0793 2b005d319dfe62166c2baea10c625564 866 PRINTS PR00868 DNA-polymerase family A (pol I) signature 722 733 1.0E-77 T 13-10-2018 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TOPB45_0793 2b005d319dfe62166c2baea10c625564 866 PRINTS PR00868 DNA-polymerase family A (pol I) signature 744 755 1.0E-77 T 13-10-2018 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TOPB45_0793 2b005d319dfe62166c2baea10c625564 866 PRINTS PR00868 DNA-polymerase family A (pol I) signature 586 608 1.0E-77 T 13-10-2018 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TOPB45_0793 2b005d319dfe62166c2baea10c625564 866 PRINTS PR00868 DNA-polymerase family A (pol I) signature 776 792 1.0E-77 T 13-10-2018 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TOPB45_0793 2b005d319dfe62166c2baea10c625564 866 PRINTS PR00868 DNA-polymerase family A (pol I) signature 609 624 1.0E-77 T 13-10-2018 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TOPB45_0793 2b005d319dfe62166c2baea10c625564 866 PRINTS PR00868 DNA-polymerase family A (pol I) signature 631 654 1.0E-77 T 13-10-2018 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TOPB45_0793 2b005d319dfe62166c2baea10c625564 866 PRINTS PR00868 DNA-polymerase family A (pol I) signature 685 710 1.0E-77 T 13-10-2018 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TOPB45_0793 2b005d319dfe62166c2baea10c625564 866 PRINTS PR00868 DNA-polymerase family A (pol I) signature 806 819 1.0E-77 T 13-10-2018 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TOPB45_0793 2b005d319dfe62166c2baea10c625564 866 TIGRFAM TIGR00593 pola: DNA polymerase I 15 866 5.6E-271 T 13-10-2018 IPR018320 DNA polymerase 1 GO:0003887|GO:0006260 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TOPB45_0793 2b005d319dfe62166c2baea10c625564 866 SMART SM00475 9 268 3.8E-94 T 13-10-2018 IPR002421 5'-3' exonuclease, N-terminal GO:0003677 TOPB45_0793 2b005d319dfe62166c2baea10c625564 866 Gene3D G3DSA:3.30.70.370 593 862 1.0E-108 T 13-10-2018 TOPB45_0793 2b005d319dfe62166c2baea10c625564 866 ProSitePatterns PS00447 DNA polymerase family A signature. 685 704 - T 13-10-2018 IPR019760 DNA-directed DNA polymerase, family A, conserved site GO:0003887|GO:0006260 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TOPB45_0793 2b005d319dfe62166c2baea10c625564 866 Gene3D G3DSA:1.20.1060.10 473 589 3.8E-34 T 13-10-2018 TOPB45_0793 2b005d319dfe62166c2baea10c625564 866 Pfam PF01367 5'-3' exonuclease, C-terminal SAM fold 179 263 8.6E-24 T 13-10-2018 IPR020045 DNA polymerase I-like, H3TH domain GO:0003677|GO:0003824 TOPB45_0793 2b005d319dfe62166c2baea10c625564 866 SMART SM00279 180 215 4.3E-12 T 13-10-2018 IPR008918 Helix-hairpin-helix motif, class 2 GO:0003677|GO:0003824 TOPB45_0793 2b005d319dfe62166c2baea10c625564 866 Gene3D G3DSA:3.30.420.10 316 472 2.2E-17 T 13-10-2018 IPR036397 Ribonuclease H superfamily GO:0003676 TOPB45_0793 2b005d319dfe62166c2baea10c625564 866 Pfam PF02739 5'-3' exonuclease, N-terminal resolvase-like domain 14 176 4.9E-47 T 13-10-2018 IPR020046 5'-3' exonuclease, alpha-helical arch, N-terminal GO:0003677 TOPB45_0793 2b005d319dfe62166c2baea10c625564 866 Gene3D G3DSA:3.40.50.1010 15 286 6.6E-89 T 13-10-2018 TOPB45_0701 0c563567b86db72e5d1911aae2d19d9a 267 TIGRFAM TIGR00195 exoDNase_III: exodeoxyribonuclease III 4 265 3.8E-77 T 13-10-2018 TOPB45_0701 0c563567b86db72e5d1911aae2d19d9a 267 Pfam PF03372 Endonuclease/Exonuclease/phosphatase family 4 243 2.6E-22 T 13-10-2018 IPR005135 Endonuclease/exonuclease/phosphatase TOPB45_0701 0c563567b86db72e5d1911aae2d19d9a 267 SUPERFAMILY SSF56219 1 266 4.32E-74 T 13-10-2018 IPR036691 Endonuclease/exonuclease/phosphatase superfamily TOPB45_0701 0c563567b86db72e5d1911aae2d19d9a 267 Gene3D G3DSA:3.60.10.10 1 267 1.8E-71 T 13-10-2018 IPR036691 Endonuclease/exonuclease/phosphatase superfamily TOPB45_0701 0c563567b86db72e5d1911aae2d19d9a 267 TIGRFAM TIGR00633 xth: exodeoxyribonuclease III (xth) 3 266 4.0E-68 T 13-10-2018 IPR004808 AP endonuclease 1 GO:0004518|GO:0006281 TOPB45_0005 02d4049e416e289fa82481c39eb939ec 342 Gene3D G3DSA:2.30.30.60 183 234 5.5E-13 T 13-10-2018 IPR023408 Mechanosensitive ion channel MscS domain superfamily TOPB45_0005 02d4049e416e289fa82481c39eb939ec 342 Gene3D G3DSA:3.30.70.100 239 333 1.2E-20 T 13-10-2018 TOPB45_0005 02d4049e416e289fa82481c39eb939ec 342 Pfam PF00924 Mechanosensitive ion channel 126 329 3.4E-50 T 13-10-2018 IPR006685 Mechanosensitive ion channel MscS GO:0016020|GO:0055085 TOPB45_0005 02d4049e416e289fa82481c39eb939ec 342 SUPERFAMILY SSF82689 242 339 6.28E-23 T 13-10-2018 IPR011066 Mechanosensitive ion channel MscS, C-terminal GO:0016020 TOPB45_0005 02d4049e416e289fa82481c39eb939ec 342 SUPERFAMILY SSF50182 167 233 1.31E-17 T 13-10-2018 IPR010920 LSM domain superfamily TOPB45_0005 02d4049e416e289fa82481c39eb939ec 342 SUPERFAMILY SSF82861 83 166 2.75E-14 T 13-10-2018 IPR011014 Mechanosensitive ion channel MscS, transmembrane-2 GO:0016020 TOPB45_0216 ce3d757da83e8aefa0858505064c2f3c 183 Gene3D G3DSA:1.10.3210.10 8 178 5.9E-14 T 13-10-2018 TOPB45_0216 ce3d757da83e8aefa0858505064c2f3c 183 Pfam PF01966 HD domain 22 138 5.1E-10 T 13-10-2018 IPR006674 HD domain TOPB45_0216 ce3d757da83e8aefa0858505064c2f3c 183 TIGRFAM TIGR00277 HDIG: HDIG domain 18 93 4.3E-9 T 13-10-2018 IPR006675 HDIG domain TOPB45_0216 ce3d757da83e8aefa0858505064c2f3c 183 SMART SM00471 17 150 0.0016 T 13-10-2018 IPR003607 HD/PDEase domain TOPB45_0216 ce3d757da83e8aefa0858505064c2f3c 183 SUPERFAMILY SSF109604 21 145 2.04E-14 T 13-10-2018 TOPB45_0400 ad1657f144b4dc53c5000a8676d4afec 593 Pfam PF01268 Formate--tetrahydrofolate ligase 14 593 4.2E-229 T 13-10-2018 IPR000559 Formate-tetrahydrofolate ligase, FTHFS GO:0004329|GO:0005524 KEGG: 00670+6.3.4.3|KEGG: 00720+6.3.4.3|MetaCyc: PWY-1722|MetaCyc: PWY-2161|MetaCyc: PWY-2201|MetaCyc: PWY-3841|Reactome: R-HSA-196757 TOPB45_0400 ad1657f144b4dc53c5000a8676d4afec 593 Gene3D G3DSA:3.40.50.300 24 473 4.7E-181 T 13-10-2018 TOPB45_0400 ad1657f144b4dc53c5000a8676d4afec 593 Gene3D G3DSA:3.30.1510.10 144 275 4.7E-181 T 13-10-2018 TOPB45_0400 ad1657f144b4dc53c5000a8676d4afec 593 Hamap MF_01543 Formate--tetrahydrofolate ligase [fhs]. 13 593 39.616 T 13-10-2018 IPR000559 Formate-tetrahydrofolate ligase, FTHFS GO:0004329|GO:0005524 KEGG: 00670+6.3.4.3|KEGG: 00720+6.3.4.3|MetaCyc: PWY-1722|MetaCyc: PWY-2161|MetaCyc: PWY-2201|MetaCyc: PWY-3841|Reactome: R-HSA-196757 TOPB45_0400 ad1657f144b4dc53c5000a8676d4afec 593 Gene3D G3DSA:3.10.410.10 478 567 8.1E-32 T 13-10-2018 TOPB45_0400 ad1657f144b4dc53c5000a8676d4afec 593 SUPERFAMILY SSF52540 17 590 1.19E-204 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1508 801435aca08d0a84745abf82e517f659 540 Pfam PF07724 AAA domain (Cdc48 subfamily) 79 281 1.0E-33 T 13-10-2018 IPR003959 ATPase, AAA-type, core GO:0005524 TOPB45_1508 801435aca08d0a84745abf82e517f659 540 Gene3D G3DSA:1.10.8.60 286 386 1.5E-20 T 13-10-2018 TOPB45_1508 801435aca08d0a84745abf82e517f659 540 SMART SM01086 287 378 1.0E-4 T 13-10-2018 IPR019489 Clp ATPase, C-terminal TOPB45_1508 801435aca08d0a84745abf82e517f659 540 SMART SM00382 76 267 6.9E-7 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_1508 801435aca08d0a84745abf82e517f659 540 Gene3D G3DSA:3.40.50.300 20 284 7.2E-79 T 13-10-2018 TOPB45_1508 801435aca08d0a84745abf82e517f659 540 SUPERFAMILY SSF52540 80 488 5.04E-5 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1508 801435aca08d0a84745abf82e517f659 540 Pfam PF10431 C-terminal, D2-small domain, of ClpB protein 287 350 4.2E-8 T 13-10-2018 IPR019489 Clp ATPase, C-terminal TOPB45_1508 801435aca08d0a84745abf82e517f659 540 SUPERFAMILY SSF52540 22 371 9.0E-50 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1393 ea14606f0ce520c4923cc4df18b87483 539 Gene3D G3DSA:3.30.260.10 138 410 6.4E-246 T 13-10-2018 IPR027410 TCP-1-like chaperonin intermediate domain superfamily TOPB45_1393 ea14606f0ce520c4923cc4df18b87483 539 Gene3D G3DSA:1.10.560.10 8 520 6.4E-246 T 13-10-2018 IPR027413 GroEL-like equatorial domain superfamily TOPB45_1393 ea14606f0ce520c4923cc4df18b87483 539 Gene3D G3DSA:3.50.7.10 173 379 6.4E-246 T 13-10-2018 IPR027409 GroEL-like apical domain superfamily TOPB45_1393 ea14606f0ce520c4923cc4df18b87483 539 Hamap MF_00600 60 kDa chaperonin [groL]. 2 539 42.12 T 13-10-2018 IPR001844 Chaperonin Cpn60 GO:0005737|GO:0042026 Reactome: R-HSA-1268020|Reactome: R-HSA-8869496 TOPB45_1393 ea14606f0ce520c4923cc4df18b87483 539 SUPERFAMILY SSF48592 7 520 2.06E-81 T 13-10-2018 IPR027413 GroEL-like equatorial domain superfamily TOPB45_1393 ea14606f0ce520c4923cc4df18b87483 539 SUPERFAMILY SSF52029 184 376 1.08E-88 T 13-10-2018 IPR027409 GroEL-like apical domain superfamily TOPB45_1393 ea14606f0ce520c4923cc4df18b87483 539 ProSitePatterns PS00296 Chaperonins cpn60 signature. 405 416 - T 13-10-2018 IPR018370 Chaperonin Cpn60, conserved site GO:0005524|GO:0005737|GO:0006457 Reactome: R-HSA-1268020|Reactome: R-HSA-8869496 TOPB45_1393 ea14606f0ce520c4923cc4df18b87483 539 PRINTS PR00298 60kDa chaperonin signature 83 110 1.0E-72 T 13-10-2018 IPR001844 Chaperonin Cpn60 GO:0005737|GO:0042026 Reactome: R-HSA-1268020|Reactome: R-HSA-8869496 TOPB45_1393 ea14606f0ce520c4923cc4df18b87483 539 PRINTS PR00298 60kDa chaperonin signature 398 419 1.0E-72 T 13-10-2018 IPR001844 Chaperonin Cpn60 GO:0005737|GO:0042026 Reactome: R-HSA-1268020|Reactome: R-HSA-8869496 TOPB45_1393 ea14606f0ce520c4923cc4df18b87483 539 PRINTS PR00298 60kDa chaperonin signature 27 53 1.0E-72 T 13-10-2018 IPR001844 Chaperonin Cpn60 GO:0005737|GO:0042026 Reactome: R-HSA-1268020|Reactome: R-HSA-8869496 TOPB45_1393 ea14606f0ce520c4923cc4df18b87483 539 PRINTS PR00298 60kDa chaperonin signature 268 291 1.0E-72 T 13-10-2018 IPR001844 Chaperonin Cpn60 GO:0005737|GO:0042026 Reactome: R-HSA-1268020|Reactome: R-HSA-8869496 TOPB45_1393 ea14606f0ce520c4923cc4df18b87483 539 PRINTS PR00298 60kDa chaperonin signature 350 375 1.0E-72 T 13-10-2018 IPR001844 Chaperonin Cpn60 GO:0005737|GO:0042026 Reactome: R-HSA-1268020|Reactome: R-HSA-8869496 TOPB45_1393 ea14606f0ce520c4923cc4df18b87483 539 TIGRFAM TIGR02348 GroEL: chaperonin GroL 3 526 7.1E-266 T 13-10-2018 IPR001844 Chaperonin Cpn60 GO:0005737|GO:0042026 Reactome: R-HSA-1268020|Reactome: R-HSA-8869496 TOPB45_1393 ea14606f0ce520c4923cc4df18b87483 539 Pfam PF00118 TCP-1/cpn60 chaperonin family 23 523 2.4E-107 T 13-10-2018 IPR002423 Chaperonin Cpn60/TCP-1 family GO:0005524 TOPB45_1393 ea14606f0ce520c4923cc4df18b87483 539 SUPERFAMILY SSF54849 137 204 3.66E-25 T 13-10-2018 IPR027410 TCP-1-like chaperonin intermediate domain superfamily TOPB45_0297 c783e28ec007d2bf5a98bcb592f999b3 237 SMART SM00358 161 228 7.7E-22 T 13-10-2018 IPR014720 Double-stranded RNA-binding domain TOPB45_0297 c783e28ec007d2bf5a98bcb592f999b3 237 ProSitePatterns PS00517 Ribonuclease III family signature. 44 52 - T 13-10-2018 IPR000999 Ribonuclease III domain GO:0004525|GO:0006396 Reactome: R-HSA-203927 TOPB45_0297 c783e28ec007d2bf5a98bcb592f999b3 237 TIGRFAM TIGR02191 RNaseIII: ribonuclease III 8 226 9.8E-69 T 13-10-2018 IPR011907 Ribonuclease III GO:0003723|GO:0004525|GO:0016075 Reactome: R-HSA-203927 TOPB45_0297 c783e28ec007d2bf5a98bcb592f999b3 237 Hamap MF_00104 Ribonuclease 3 [rnc]. 8 224 27.881 T 13-10-2018 IPR011907 Ribonuclease III GO:0003723|GO:0004525|GO:0016075 Reactome: R-HSA-203927 TOPB45_0297 c783e28ec007d2bf5a98bcb592f999b3 237 SUPERFAMILY SSF54768 156 228 7.77E-22 T 13-10-2018 TOPB45_0297 c783e28ec007d2bf5a98bcb592f999b3 237 Gene3D G3DSA:3.30.160.20 160 226 6.6E-21 T 13-10-2018 TOPB45_0297 c783e28ec007d2bf5a98bcb592f999b3 237 Pfam PF00035 Double-stranded RNA binding motif 161 227 1.4E-19 T 13-10-2018 IPR014720 Double-stranded RNA-binding domain TOPB45_0297 c783e28ec007d2bf5a98bcb592f999b3 237 Gene3D G3DSA:1.10.1520.10 3 148 7.7E-43 T 13-10-2018 IPR036389 Ribonuclease III, endonuclease domain superfamily GO:0004525|GO:0006396 TOPB45_0297 c783e28ec007d2bf5a98bcb592f999b3 237 Pfam PF14622 Ribonuclease-III-like 18 143 6.1E-34 T 13-10-2018 IPR000999 Ribonuclease III domain GO:0004525|GO:0006396 Reactome: R-HSA-203927 TOPB45_0297 c783e28ec007d2bf5a98bcb592f999b3 237 SMART SM00535 20 155 1.7E-39 T 13-10-2018 IPR000999 Ribonuclease III domain GO:0004525|GO:0006396 Reactome: R-HSA-203927 TOPB45_0297 c783e28ec007d2bf5a98bcb592f999b3 237 SUPERFAMILY SSF69065 3 163 1.55E-43 T 13-10-2018 IPR036389 Ribonuclease III, endonuclease domain superfamily GO:0004525|GO:0006396 TOPB45_1597 ed42e8d31bd2fe268f997015a245634e 249 SUPERFAMILY SSF51735 6 247 1.66E-95 T 13-10-2018 IPR036291 NAD(P)-binding domain superfamily TOPB45_1597 ed42e8d31bd2fe268f997015a245634e 249 TIGRFAM TIGR01829 AcAcCoA_reduct: acetoacetyl-CoA reductase 7 247 2.3E-92 T 13-10-2018 IPR011283 Acetoacetyl-CoA reductase GO:0005737|GO:0018454|GO:0042619|GO:0055114 KEGG: 00630+1.1.1.36|KEGG: 00650+1.1.1.36|MetaCyc: PWY-5676|MetaCyc: PWY-5741|MetaCyc: PWY-7216|MetaCyc: PWY-7948 TOPB45_1597 ed42e8d31bd2fe268f997015a245634e 249 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 7 192 3.6E-6 T 13-10-2018 TOPB45_1597 ed42e8d31bd2fe268f997015a245634e 249 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 13 246 1.9E-72 T 13-10-2018 TOPB45_1597 ed42e8d31bd2fe268f997015a245634e 249 TIGRFAM TIGR01830 3oxo_ACP_reduc: 3-oxoacyl-[acyl-carrier-protein] reductase 9 247 7.9E-107 T 13-10-2018 IPR011284 3-oxoacyl-(acyl-carrier-protein) reductase GO:0004316|GO:0006633|GO:0051287|GO:0055114 KEGG: 00061+1.1.1.100|KEGG: 00780+1.1.1.100|MetaCyc: PWY-5367|MetaCyc: PWY-5971|MetaCyc: PWY-5973|MetaCyc: PWY-5989|MetaCyc: PWY-5994|MetaCyc: PWY-6113|MetaCyc: PWY-6282|MetaCyc: PWY-6519|MetaCyc: PWY-7388|MetaCyc: PWY-7663|MetaCyc: PWY-7664|MetaCyc: PWY-7858|MetaCyc: PWYG-321 TOPB45_1597 ed42e8d31bd2fe268f997015a245634e 249 Gene3D G3DSA:3.40.50.720 2 248 2.9E-92 T 13-10-2018 TOPB45_1597 ed42e8d31bd2fe268f997015a245634e 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 177 194 6.8E-47 T 13-10-2018 IPR002347 Short-chain dehydrogenase/reductase SDR TOPB45_1597 ed42e8d31bd2fe268f997015a245634e 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 8 25 6.8E-47 T 13-10-2018 IPR002347 Short-chain dehydrogenase/reductase SDR TOPB45_1597 ed42e8d31bd2fe268f997015a245634e 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 83 94 6.8E-47 T 13-10-2018 IPR002347 Short-chain dehydrogenase/reductase SDR TOPB45_1597 ed42e8d31bd2fe268f997015a245634e 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 156 175 6.8E-47 T 13-10-2018 IPR002347 Short-chain dehydrogenase/reductase SDR TOPB45_1597 ed42e8d31bd2fe268f997015a245634e 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 210 230 6.8E-47 T 13-10-2018 IPR002347 Short-chain dehydrogenase/reductase SDR TOPB45_1597 ed42e8d31bd2fe268f997015a245634e 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 130 146 6.8E-47 T 13-10-2018 IPR002347 Short-chain dehydrogenase/reductase SDR TOPB45_1597 ed42e8d31bd2fe268f997015a245634e 249 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 156 175 3.5E-15 T 13-10-2018 IPR002347 Short-chain dehydrogenase/reductase SDR TOPB45_1597 ed42e8d31bd2fe268f997015a245634e 249 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 136 144 3.5E-15 T 13-10-2018 IPR002347 Short-chain dehydrogenase/reductase SDR TOPB45_1597 ed42e8d31bd2fe268f997015a245634e 249 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 83 94 3.5E-15 T 13-10-2018 IPR002347 Short-chain dehydrogenase/reductase SDR TOPB45_1597 ed42e8d31bd2fe268f997015a245634e 249 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 143 171 - T 13-10-2018 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 TOPB45_1378 6fa91d130e1ded178cd817978869a962 123 TIGRFAM TIGR00090 rsfS_iojap_ybeB: ribosome silencing factor 7 104 2.1E-30 T 13-10-2018 IPR004394 Protein Iojap/ribosomal silencing factor RsfS TOPB45_1378 6fa91d130e1ded178cd817978869a962 123 SUPERFAMILY SSF81301 1 111 2.13E-33 T 13-10-2018 TOPB45_1378 6fa91d130e1ded178cd817978869a962 123 Gene3D G3DSA:3.30.460.10 1 118 2.7E-33 T 13-10-2018 TOPB45_1378 6fa91d130e1ded178cd817978869a962 123 Pfam PF02410 Ribosomal silencing factor during starvation 10 104 2.1E-22 T 13-10-2018 TOPB45_1378 6fa91d130e1ded178cd817978869a962 123 Hamap MF_01477 Ribosomal silencing factor RsfS [rsfS]. 3 105 21.46 T 13-10-2018 IPR004394 Protein Iojap/ribosomal silencing factor RsfS TOPB45_0881 aa0f6f7310173b752dcc0cc5465c8e7d 510 PRINTS PR01657 Mini-chromosome maintenance (MCM) protein family signature 210 225 5.6E-5 T 13-10-2018 IPR001208 MCM domain GO:0003677|GO:0005524|GO:0006270 TOPB45_0881 aa0f6f7310173b752dcc0cc5465c8e7d 510 PRINTS PR01657 Mini-chromosome maintenance (MCM) protein family signature 291 305 5.6E-5 T 13-10-2018 IPR001208 MCM domain GO:0003677|GO:0005524|GO:0006270 TOPB45_0881 aa0f6f7310173b752dcc0cc5465c8e7d 510 PRINTS PR01657 Mini-chromosome maintenance (MCM) protein family signature 319 332 5.6E-5 T 13-10-2018 IPR001208 MCM domain GO:0003677|GO:0005524|GO:0006270 TOPB45_0881 aa0f6f7310173b752dcc0cc5465c8e7d 510 SMART SM00382 211 394 6.8E-6 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_0881 aa0f6f7310173b752dcc0cc5465c8e7d 510 Gene3D G3DSA:3.30.230.10 16 170 3.7E-18 T 13-10-2018 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup TOPB45_0881 aa0f6f7310173b752dcc0cc5465c8e7d 510 Gene3D G3DSA:3.40.50.300 188 504 2.8E-65 T 13-10-2018 TOPB45_0881 aa0f6f7310173b752dcc0cc5465c8e7d 510 TIGRFAM TIGR00368 TIGR00368: Mg chelatase-like protein 8 501 1.6E-190 T 13-10-2018 IPR004482 Mg chelatase-related protein TOPB45_0881 aa0f6f7310173b752dcc0cc5465c8e7d 510 SUPERFAMILY SSF54211 6 169 1.4E-38 T 13-10-2018 IPR020568 Ribosomal protein S5 domain 2-type fold TOPB45_0881 aa0f6f7310173b752dcc0cc5465c8e7d 510 Pfam PF13335 Magnesium chelatase, subunit ChlI C-terminal 408 501 3.8E-30 T 13-10-2018 IPR025158 Mg chelatase-related protein, C-terminal domain TOPB45_0881 aa0f6f7310173b752dcc0cc5465c8e7d 510 SUPERFAMILY SSF52540 189 503 1.12E-47 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0881 aa0f6f7310173b752dcc0cc5465c8e7d 510 Pfam PF13541 Subunit ChlI of Mg-chelatase 20 142 2.5E-46 T 13-10-2018 TOPB45_0881 aa0f6f7310173b752dcc0cc5465c8e7d 510 Pfam PF01078 Magnesium chelatase, subunit ChlI 191 397 1.4E-94 T 13-10-2018 IPR000523 Magnesium chelatase ChlI domain TOPB45_1240 5438bb51c415b3f0b28101ba7d1c2c1a 72 SUPERFAMILY SSF64307 2 71 8.24E-20 T 13-10-2018 IPR036868 TusA-like domain superfamily TOPB45_1240 5438bb51c415b3f0b28101ba7d1c2c1a 72 ProSitePatterns PS01148 Uncharacterized protein family UPF0033 signature. 5 29 - T 13-10-2018 IPR001455 TusA-like domain TOPB45_1240 5438bb51c415b3f0b28101ba7d1c2c1a 72 Pfam PF01206 Sulfurtransferase TusA 4 71 2.8E-19 T 13-10-2018 IPR001455 TusA-like domain TOPB45_1240 5438bb51c415b3f0b28101ba7d1c2c1a 72 Gene3D G3DSA:3.30.110.40 3 72 1.8E-18 T 13-10-2018 IPR036868 TusA-like domain superfamily TOPB45_1524 76cc50c439202b6b37c12b07e4803599 138 SUPERFAMILY SSF47781 25 84 2.11E-30 T 13-10-2018 IPR010994 RuvA domain 2-like TOPB45_1524 76cc50c439202b6b37c12b07e4803599 138 SMART SM00278 65 84 0.0073 T 13-10-2018 IPR003583 Helix-hairpin-helix DNA-binding motif, class 1 GO:0003677|GO:0006281 TOPB45_1524 76cc50c439202b6b37c12b07e4803599 138 SMART SM00278 35 54 1.4E-4 T 13-10-2018 IPR003583 Helix-hairpin-helix DNA-binding motif, class 1 GO:0003677|GO:0006281 TOPB45_1524 76cc50c439202b6b37c12b07e4803599 138 TIGRFAM TIGR00426 TIGR00426: competence protein ComEA helix-hairpin-helix repeat region 25 85 4.7E-22 T 13-10-2018 IPR004509 Competence protein ComEA, helix-hairpin-helix domain TOPB45_1524 76cc50c439202b6b37c12b07e4803599 138 Pfam PF12836 Helix-hairpin-helix motif 24 85 1.1E-30 T 13-10-2018 TOPB45_1524 76cc50c439202b6b37c12b07e4803599 138 Gene3D G3DSA:1.10.150.320 18 86 2.6E-27 T 13-10-2018 TOPB45_1380 ad6036b76f54ee4f590d43e9acf45858 614 SUPERFAMILY SSF53697 248 614 2.74E-105 T 13-10-2018 TOPB45_1380 ad6036b76f54ee4f590d43e9acf45858 614 Gene3D G3DSA:3.40.50.10490 250 613 1.7E-142 T 13-10-2018 TOPB45_1380 ad6036b76f54ee4f590d43e9acf45858 614 Gene3D G3DSA:3.40.50.10490 449 599 1.7E-142 T 13-10-2018 TOPB45_1380 ad6036b76f54ee4f590d43e9acf45858 614 Pfam PF13522 Glutamine amidotransferase domain 70 178 4.5E-21 T 13-10-2018 TOPB45_1380 ad6036b76f54ee4f590d43e9acf45858 614 Pfam PF01380 SIS domain 468 596 1.1E-18 T 13-10-2018 IPR001347 Sugar isomerase (SIS) GO:0097367|GO:1901135 TOPB45_1380 ad6036b76f54ee4f590d43e9acf45858 614 Pfam PF01380 SIS domain 296 418 4.0E-33 T 13-10-2018 IPR001347 Sugar isomerase (SIS) GO:0097367|GO:1901135 TOPB45_1380 ad6036b76f54ee4f590d43e9acf45858 614 SUPERFAMILY SSF56235 2 239 4.72E-73 T 13-10-2018 IPR029055 Nucleophile aminohydrolases, N-terminal TOPB45_1380 ad6036b76f54ee4f590d43e9acf45858 614 TIGRFAM TIGR01135 glmS: glutamine-fructose-6-phosphate transaminase (isomerizing) 2 614 2.0E-248 T 13-10-2018 IPR005855 Glucosamine-fructose-6-phosphate aminotransferase, isomerising GO:0004360|GO:1901137 KEGG: 00250+2.6.1.16|KEGG: 00520+2.6.1.16|MetaCyc: PWY-6749|Reactome: R-HSA-446210 TOPB45_1380 ad6036b76f54ee4f590d43e9acf45858 614 Hamap MF_00164 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] [glmS]. 1 614 40.763 T 13-10-2018 IPR005855 Glucosamine-fructose-6-phosphate aminotransferase, isomerising GO:0004360|GO:1901137 KEGG: 00250+2.6.1.16|KEGG: 00520+2.6.1.16|MetaCyc: PWY-6749|Reactome: R-HSA-446210 TOPB45_1380 ad6036b76f54ee4f590d43e9acf45858 614 Gene3D G3DSA:3.60.20.10 2 242 7.2E-75 T 13-10-2018 IPR029055 Nucleophile aminohydrolases, N-terminal TOPB45_1132 43a6fa2004db04a9d0c262fc6787f271 686 SUPERFAMILY SSF47781 420 599 8.53E-63 T 13-10-2018 IPR010994 RuvA domain 2-like TOPB45_1132 43a6fa2004db04a9d0c262fc6787f271 686 ProSitePatterns PS01056 NAD-dependent DNA ligase signature 2. 348 363 - T 13-10-2018 IPR033136 NAD-dependent DNA ligase, conserved site TOPB45_1132 43a6fa2004db04a9d0c262fc6787f271 686 Gene3D G3DSA:1.10.150.20 522 601 1.2E-29 T 13-10-2018 TOPB45_1132 43a6fa2004db04a9d0c262fc6787f271 686 Pfam PF03120 NAD-dependent DNA ligase OB-fold domain 338 415 1.0E-34 T 13-10-2018 IPR004150 NAD-dependent DNA ligase, OB-fold GO:0003911|GO:0006260|GO:0006281 TOPB45_1132 43a6fa2004db04a9d0c262fc6787f271 686 Pfam PF01653 NAD-dependent DNA ligase adenylation domain 15 334 4.2E-129 T 13-10-2018 IPR013839 NAD-dependent DNA ligase, adenylation GO:0003911 TOPB45_1132 43a6fa2004db04a9d0c262fc6787f271 686 Pfam PF00533 BRCA1 C Terminus (BRCT) domain 607 682 2.9E-20 T 13-10-2018 IPR001357 BRCT domain TOPB45_1132 43a6fa2004db04a9d0c262fc6787f271 686 Gene3D G3DSA:3.30.470.90 80 335 1.6E-99 T 13-10-2018 TOPB45_1132 43a6fa2004db04a9d0c262fc6787f271 686 Pfam PF12826 Helix-hairpin-helix motif 526 589 5.3E-26 T 13-10-2018 TOPB45_1132 43a6fa2004db04a9d0c262fc6787f271 686 Pfam PF14520 Helix-hairpin-helix domain 464 518 3.5E-7 T 13-10-2018 TOPB45_1132 43a6fa2004db04a9d0c262fc6787f271 686 SMART SM00532 14 464 6.7E-267 T 13-10-2018 IPR013840 NAD-dependent DNA ligase, N-terminal GO:0003911 TOPB45_1132 43a6fa2004db04a9d0c262fc6787f271 686 Gene3D G3DSA:1.10.150.20 448 521 9.2E-26 T 13-10-2018 TOPB45_1132 43a6fa2004db04a9d0c262fc6787f271 686 SUPERFAMILY SSF50249 335 417 1.08E-27 T 13-10-2018 IPR012340 Nucleic acid-binding, OB-fold TOPB45_1132 43a6fa2004db04a9d0c262fc6787f271 686 Hamap MF_01588 DNA ligase [ligA]. 13 682 52.845 T 13-10-2018 IPR001679 NAD-dependent DNA ligase GO:0003911|GO:0006260|GO:0006281 TOPB45_1132 43a6fa2004db04a9d0c262fc6787f271 686 ProSitePatterns PS01055 NAD-dependent DNA ligase signature 1. 128 157 - T 13-10-2018 IPR018239 NAD-dependent DNA ligase, active site TOPB45_1132 43a6fa2004db04a9d0c262fc6787f271 686 Gene3D G3DSA:3.40.50.10190 605 686 4.2E-29 T 13-10-2018 IPR036420 BRCT domain superfamily TOPB45_1132 43a6fa2004db04a9d0c262fc6787f271 686 Gene3D G3DSA:1.10.287.610 13 79 6.9E-31 T 13-10-2018 TOPB45_1132 43a6fa2004db04a9d0c262fc6787f271 686 SMART SM00278 496 515 10.0 T 13-10-2018 IPR003583 Helix-hairpin-helix DNA-binding motif, class 1 GO:0003677|GO:0006281 TOPB45_1132 43a6fa2004db04a9d0c262fc6787f271 686 SMART SM00278 560 579 0.6 T 13-10-2018 IPR003583 Helix-hairpin-helix DNA-binding motif, class 1 GO:0003677|GO:0006281 TOPB45_1132 43a6fa2004db04a9d0c262fc6787f271 686 SMART SM00278 462 481 12.0 T 13-10-2018 IPR003583 Helix-hairpin-helix DNA-binding motif, class 1 GO:0003677|GO:0006281 TOPB45_1132 43a6fa2004db04a9d0c262fc6787f271 686 SMART SM00278 528 547 140.0 T 13-10-2018 IPR003583 Helix-hairpin-helix DNA-binding motif, class 1 GO:0003677|GO:0006281 TOPB45_1132 43a6fa2004db04a9d0c262fc6787f271 686 Pfam PF03119 NAD-dependent DNA ligase C4 zinc finger domain 424 450 1.5E-10 T 13-10-2018 IPR004149 Zinc-finger, NAD-dependent DNA ligase C4-type GO:0003911|GO:0006260|GO:0006281 TOPB45_1132 43a6fa2004db04a9d0c262fc6787f271 686 Gene3D G3DSA:2.20.70.80 408 446 3.0E-11 T 13-10-2018 TOPB45_1132 43a6fa2004db04a9d0c262fc6787f271 686 SUPERFAMILY SSF52113 605 684 1.89E-22 T 13-10-2018 IPR036420 BRCT domain superfamily TOPB45_1132 43a6fa2004db04a9d0c262fc6787f271 686 SUPERFAMILY SSF56091 13 332 2.24E-120 T 13-10-2018 TOPB45_1132 43a6fa2004db04a9d0c262fc6787f271 686 TIGRFAM TIGR00575 dnlj: DNA ligase, NAD-dependent 22 678 2.8E-267 T 13-10-2018 IPR001679 NAD-dependent DNA ligase GO:0003911|GO:0006260|GO:0006281 TOPB45_1132 43a6fa2004db04a9d0c262fc6787f271 686 SMART SM00292 608 685 2.8E-19 T 13-10-2018 IPR001357 BRCT domain TOPB45_1132 43a6fa2004db04a9d0c262fc6787f271 686 Gene3D G3DSA:2.40.50.140 336 407 4.0E-32 T 13-10-2018 TOPB45_1132 43a6fa2004db04a9d0c262fc6787f271 686 PIRSF PIRSF001604 6 686 7.8E-265 T 13-10-2018 IPR001679 NAD-dependent DNA ligase GO:0003911|GO:0006260|GO:0006281 TOPB45_0548 75f62b24375b2be4ab987496e0906d64 295 Pfam PF02548 Ketopantoate hydroxymethyltransferase 14 262 1.5E-100 T 13-10-2018 IPR003700 Ketopantoate hydroxymethyltransferase GO:0003864|GO:0015940 KEGG: 00770+2.1.2.11|MetaCyc: PWY-6654 TOPB45_0548 75f62b24375b2be4ab987496e0906d64 295 Gene3D G3DSA:3.20.20.60 10 277 5.8E-105 T 13-10-2018 TOPB45_0548 75f62b24375b2be4ab987496e0906d64 295 SUPERFAMILY SSF51621 8 266 6.67E-94 T 13-10-2018 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily GO:0003824 TOPB45_0548 75f62b24375b2be4ab987496e0906d64 295 Hamap MF_00156 3-methyl-2-oxobutanoate hydroxymethyltransferase [panB]. 6 266 38.978 T 13-10-2018 IPR003700 Ketopantoate hydroxymethyltransferase GO:0003864|GO:0015940 KEGG: 00770+2.1.2.11|MetaCyc: PWY-6654 TOPB45_0548 75f62b24375b2be4ab987496e0906d64 295 PIRSF PIRSF000388 7 269 9.5E-102 T 13-10-2018 IPR003700 Ketopantoate hydroxymethyltransferase GO:0003864|GO:0015940 KEGG: 00770+2.1.2.11|MetaCyc: PWY-6654 TOPB45_0548 75f62b24375b2be4ab987496e0906d64 295 TIGRFAM TIGR00222 panB: 3-methyl-2-oxobutanoate hydroxymethyltransferase 11 267 9.8E-91 T 13-10-2018 IPR003700 Ketopantoate hydroxymethyltransferase GO:0003864|GO:0015940 KEGG: 00770+2.1.2.11|MetaCyc: PWY-6654 TOPB45_0596 4d9b069053f9a8a608c77a436fecaf08 97 SUPERFAMILY SSF141000 3 93 1.7E-27 T 13-10-2018 IPR036113 Glu-tRNAGln amidotransferase superfamily, subunit C GO:0006450 TOPB45_0596 4d9b069053f9a8a608c77a436fecaf08 97 TIGRFAM TIGR00135 gatC: aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit 3 94 7.6E-26 T 13-10-2018 IPR003837 Glu-tRNAGln amidotransferase C subunit GO:0006450 TOPB45_0596 4d9b069053f9a8a608c77a436fecaf08 97 Hamap MF_00122 Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C [gatC]. 2 95 22.603 T 13-10-2018 IPR003837 Glu-tRNAGln amidotransferase C subunit GO:0006450 TOPB45_0596 4d9b069053f9a8a608c77a436fecaf08 97 Gene3D G3DSA:1.10.20.60 1 93 2.5E-26 T 13-10-2018 TOPB45_0596 4d9b069053f9a8a608c77a436fecaf08 97 Pfam PF02686 Glu-tRNAGln amidotransferase C subunit 19 90 4.9E-19 T 13-10-2018 IPR003837 Glu-tRNAGln amidotransferase C subunit GO:0006450 TOPB45_0104 eaa00b4c46b0e05b6054090f09b58f5f 256 Gene3D G3DSA:3.20.20.70 1 255 3.4E-103 T 13-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 TOPB45_0104 eaa00b4c46b0e05b6054090f09b58f5f 256 TIGRFAM TIGR00419 tim: triose-phosphate isomerase 7 243 2.1E-60 T 13-10-2018 IPR000652 Triosephosphate isomerase GO:0004807 KEGG: 00010+5.3.1.1|KEGG: 00051+5.3.1.1|KEGG: 00562+5.3.1.1|KEGG: 00710+5.3.1.1|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6142|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_0104 eaa00b4c46b0e05b6054090f09b58f5f 256 Pfam PF00121 Triosephosphate isomerase 5 249 2.9E-95 T 13-10-2018 IPR000652 Triosephosphate isomerase GO:0004807 KEGG: 00010+5.3.1.1|KEGG: 00051+5.3.1.1|KEGG: 00562+5.3.1.1|KEGG: 00710+5.3.1.1|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6142|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_0104 eaa00b4c46b0e05b6054090f09b58f5f 256 SUPERFAMILY SSF51351 1 252 4.97E-94 T 13-10-2018 IPR035990 Triosephosphate isomerase superfamily GO:0004807 KEGG: 00010+5.3.1.1|KEGG: 00051+5.3.1.1|KEGG: 00562+5.3.1.1|KEGG: 00710+5.3.1.1|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6142|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_0104 eaa00b4c46b0e05b6054090f09b58f5f 256 Hamap MF_00147_B Triosephosphate isomerase [tpiA]. 2 251 58.32 T 13-10-2018 IPR022896 Triosephosphate isomerase, bacterial/eukaryotic GO:0004807|GO:0006096 KEGG: 00010+5.3.1.1|KEGG: 00051+5.3.1.1|KEGG: 00562+5.3.1.1|KEGG: 00710+5.3.1.1|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6142|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_0104 eaa00b4c46b0e05b6054090f09b58f5f 256 ProSitePatterns PS00171 Triosephosphate isomerase active site. 167 177 - T 13-10-2018 IPR020861 Triosephosphate isomerase, active site GO:0004807 KEGG: 00010+5.3.1.1|KEGG: 00051+5.3.1.1|KEGG: 00562+5.3.1.1|KEGG: 00710+5.3.1.1|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6142|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_0736 664995475542c9dbfac0c5d86ec85341 184 Pfam PF01871 AMMECR1 11 177 3.6E-52 T 13-10-2018 IPR002733 AMMECR1 domain TOPB45_0736 664995475542c9dbfac0c5d86ec85341 184 Hamap MF_00645 Protein . 3 175 30.299 T 13-10-2018 IPR023472 Uncharacterised protein family MJ0810 TOPB45_0736 664995475542c9dbfac0c5d86ec85341 184 SUPERFAMILY SSF143447 2 180 1.96E-60 T 13-10-2018 IPR036071 AMMECR1 domain superfamily TOPB45_0736 664995475542c9dbfac0c5d86ec85341 184 Gene3D G3DSA:3.30.1490.150 110 177 1.1E-63 T 13-10-2018 TOPB45_0736 664995475542c9dbfac0c5d86ec85341 184 Gene3D G3DSA:3.30.700.20 8 179 1.1E-63 T 13-10-2018 IPR027485 AMMECR1, N-terminal TOPB45_0736 664995475542c9dbfac0c5d86ec85341 184 TIGRFAM TIGR04335 AmmeMemoSam_A: AmmeMemoRadiSam system protein A 9 177 1.3E-59 T 13-10-2018 IPR027623 AmmeMemoRadiSam system protein A TOPB45_0736 664995475542c9dbfac0c5d86ec85341 184 TIGRFAM TIGR00296 TIGR00296: uncharacterized protein, PH0010 family 2 181 1.0E-50 T 13-10-2018 IPR023473 AMMECR1 TOPB45_0817 83e90a6a18eefb1cd18a97cfbd600da8 1073 Gene3D G3DSA:2.30.42.10 33 125 2.0E-14 T 13-10-2018 TOPB45_0817 83e90a6a18eefb1cd18a97cfbd600da8 1073 SUPERFAMILY SSF50156 35 103 2.1E-14 T 13-10-2018 IPR036034 PDZ superfamily GO:0005515 TOPB45_0817 83e90a6a18eefb1cd18a97cfbd600da8 1073 SMART SM00228 12 97 8.0E-10 T 13-10-2018 IPR001478 PDZ domain GO:0005515 TOPB45_0817 83e90a6a18eefb1cd18a97cfbd600da8 1073 Pfam PF13180 PDZ domain 36 103 2.0E-9 T 13-10-2018 IPR001478 PDZ domain GO:0005515 TOPB45_0777 dc9d580c4709f97433e2b6da5938d98a 37 Pfam PF00444 Ribosomal protein L36 1 37 6.4E-17 T 13-10-2018 IPR000473 Ribosomal protein L36 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0777 dc9d580c4709f97433e2b6da5938d98a 37 SUPERFAMILY SSF57840 1 37 2.88E-15 T 13-10-2018 IPR035977 Ribosomal protein L36 superfamily GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0777 dc9d580c4709f97433e2b6da5938d98a 37 TIGRFAM TIGR01022 rpmJ_bact: ribosomal protein bL36 1 37 8.0E-22 T 13-10-2018 IPR000473 Ribosomal protein L36 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0777 dc9d580c4709f97433e2b6da5938d98a 37 Hamap MF_00251 50S ribosomal protein L36 [rpmJ]. 1 37 16.688 T 13-10-2018 IPR000473 Ribosomal protein L36 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0777 dc9d580c4709f97433e2b6da5938d98a 37 ProSitePatterns PS00828 Ribosomal protein L36 signature. 11 36 - T 13-10-2018 IPR000473 Ribosomal protein L36 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0405 ce21769b4775779400fc255dffc0f0ca 301 SUPERFAMILY SSF48452 176 295 1.08E-15 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_0405 ce21769b4775779400fc255dffc0f0ca 301 Pfam PF13525 Outer membrane lipoprotein 182 297 1.3E-8 T 13-10-2018 IPR039565 Outer membrane lipoprotein BamD-like TOPB45_0405 ce21769b4775779400fc255dffc0f0ca 301 Hamap MF_02066 Cell division coordinator CpoB [cpoB]. 23 301 15.116 T 13-10-2018 IPR034706 Cell division coordinator CpoB GO:0051301 TOPB45_0405 ce21769b4775779400fc255dffc0f0ca 301 SMART SM00028 183 216 29.0 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_0405 ce21769b4775779400fc255dffc0f0ca 301 SMART SM00028 220 253 0.13 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_0405 ce21769b4775779400fc255dffc0f0ca 301 Gene3D G3DSA:1.25.40.10 174 301 7.9E-27 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_0941 9183e5b7d46c752a899c087b5a48a886 359 ProSitePatterns PS01348 MraY family signature 2. 187 198 - T 13-10-2018 IPR018480 Phospho-N-acetylmuramoyl-pentapeptide transferase, conserved site KEGG: 00550+2.7.8.13|MetaCyc: PWY-5265|MetaCyc: PWY-6470|MetaCyc: PWY-6471 TOPB45_0941 9183e5b7d46c752a899c087b5a48a886 359 Pfam PF00953 Glycosyl transferase family 4 99 282 1.8E-36 T 13-10-2018 IPR000715 Glycosyl transferase, family 4 GO:0008963|GO:0016021 KEGG: 00550+2.7.8.13|MetaCyc: PWY-5265|MetaCyc: PWY-6470|MetaCyc: PWY-6471|Reactome: R-HSA-446193|Reactome: R-HSA-4549356 TOPB45_0941 9183e5b7d46c752a899c087b5a48a886 359 Pfam PF10555 Phospho-N-acetylmuramoyl-pentapeptide-transferase signature 1 68 80 8.9E-4 T 13-10-2018 IPR018480 Phospho-N-acetylmuramoyl-pentapeptide transferase, conserved site KEGG: 00550+2.7.8.13|MetaCyc: PWY-5265|MetaCyc: PWY-6470|MetaCyc: PWY-6471 TOPB45_0941 9183e5b7d46c752a899c087b5a48a886 359 ProSitePatterns PS01347 MraY family signature 1. 68 80 - T 13-10-2018 IPR018480 Phospho-N-acetylmuramoyl-pentapeptide transferase, conserved site KEGG: 00550+2.7.8.13|MetaCyc: PWY-5265|MetaCyc: PWY-6470|MetaCyc: PWY-6471 TOPB45_0941 9183e5b7d46c752a899c087b5a48a886 359 TIGRFAM TIGR00445 mraY: phospho-N-acetylmuramoyl-pentapeptide-transferase 39 359 2.4E-130 T 13-10-2018 IPR003524 Phospho-N-acetylmuramoyl-pentapeptide transferase GO:0008963|GO:0016020 KEGG: 00550+2.7.8.13|MetaCyc: PWY-5265|MetaCyc: PWY-6470|MetaCyc: PWY-6471 TOPB45_0941 9183e5b7d46c752a899c087b5a48a886 359 Hamap MF_00038 Phospho-N-acetylmuramoyl-pentapeptide-transferase [mraY]. 25 357 25.469 T 13-10-2018 IPR003524 Phospho-N-acetylmuramoyl-pentapeptide transferase GO:0008963|GO:0016020 KEGG: 00550+2.7.8.13|MetaCyc: PWY-5265|MetaCyc: PWY-6470|MetaCyc: PWY-6471 TOPB45_0708 5899b06fa3489072fa9fd863dcc101c1 171 Gene3D G3DSA:2.40.30.60 2 88 1.5E-15 T 13-10-2018 IPR036976 RimM, N-terminal domain superfamily GO:0006364 TOPB45_0708 5899b06fa3489072fa9fd863dcc101c1 171 Hamap MF_00014 Ribosome maturation factor RimM [rimM]. 2 165 18.24 T 13-10-2018 IPR011961 16S rRNA processing protein RimM GO:0005840|GO:0006364|GO:0043022 TOPB45_0708 5899b06fa3489072fa9fd863dcc101c1 171 TIGRFAM TIGR02273 16S_RimM: 16S rRNA processing protein RimM 3 164 8.5E-38 T 13-10-2018 IPR011961 16S rRNA processing protein RimM GO:0005840|GO:0006364|GO:0043022 TOPB45_0708 5899b06fa3489072fa9fd863dcc101c1 171 Gene3D G3DSA:2.30.30.240 90 170 8.2E-14 T 13-10-2018 TOPB45_0708 5899b06fa3489072fa9fd863dcc101c1 171 SUPERFAMILY SSF50447 3 88 6.71E-11 T 13-10-2018 IPR009000 Translation protein, beta-barrel domain superfamily TOPB45_0708 5899b06fa3489072fa9fd863dcc101c1 171 Pfam PF05239 PRC-barrel domain 93 165 3.8E-5 T 13-10-2018 IPR027275 PRC-barrel domain TOPB45_0708 5899b06fa3489072fa9fd863dcc101c1 171 SUPERFAMILY SSF50346 95 164 1.1E-13 T 13-10-2018 IPR011033 PRC-barrel-like superfamily TOPB45_0708 5899b06fa3489072fa9fd863dcc101c1 171 Pfam PF01782 RimM N-terminal domain 5 85 2.1E-11 T 13-10-2018 IPR002676 RimM, N-terminal GO:0006364 TOPB45_1414 83d5ca755d483271decd1227c486fb0a 621 Pfam PF02779 Transketolase, pyrimidine binding domain 314 474 7.9E-43 T 13-10-2018 IPR005475 Transketolase-like, pyrimidine-binding domain TOPB45_1414 83d5ca755d483271decd1227c486fb0a 621 Pfam PF02780 Transketolase, C-terminal domain 490 609 5.0E-38 T 13-10-2018 IPR033248 Transketolase, C-terminal domain TOPB45_1414 83d5ca755d483271decd1227c486fb0a 621 ProSitePatterns PS00802 Transketolase signature 2. 420 436 - T 13-10-2018 IPR020826 Transketolase binding site KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 TOPB45_1414 83d5ca755d483271decd1227c486fb0a 621 Hamap MF_00315 1-deoxy-D-xylulose-5-phosphate synthase [dxs]. 3 620 45.553 T 13-10-2018 IPR005477 Deoxyxylulose-5-phosphate synthase GO:0008661|GO:0016114 KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 TOPB45_1414 83d5ca755d483271decd1227c486fb0a 621 SUPERFAMILY SSF52518 2 376 3.28E-77 T 13-10-2018 IPR029061 Thiamin diphosphate-binding fold TOPB45_1414 83d5ca755d483271decd1227c486fb0a 621 Gene3D G3DSA:3.40.50.970 312 484 1.4E-70 T 13-10-2018 TOPB45_1414 83d5ca755d483271decd1227c486fb0a 621 SUPERFAMILY SSF52922 486 620 6.02E-39 T 13-10-2018 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824 TOPB45_1414 83d5ca755d483271decd1227c486fb0a 621 SMART SM00861 314 478 3.1E-74 T 13-10-2018 IPR005475 Transketolase-like, pyrimidine-binding domain TOPB45_1414 83d5ca755d483271decd1227c486fb0a 621 Gene3D G3DSA:3.40.50.920 490 620 5.5E-46 T 13-10-2018 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824 TOPB45_1414 83d5ca755d483271decd1227c486fb0a 621 TIGRFAM TIGR00204 dxs: 1-deoxy-D-xylulose-5-phosphate synthase 5 614 2.5E-256 T 13-10-2018 IPR005477 Deoxyxylulose-5-phosphate synthase GO:0008661|GO:0016114 KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 TOPB45_1414 83d5ca755d483271decd1227c486fb0a 621 ProSitePatterns PS00801 Transketolase signature 1. 29 48 - T 13-10-2018 IPR005474 Transketolase, N-terminal KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 TOPB45_1414 83d5ca755d483271decd1227c486fb0a 621 Pfam PF13292 1-deoxy-D-xylulose-5-phosphate synthase 4 278 4.9E-118 T 13-10-2018 IPR005477 Deoxyxylulose-5-phosphate synthase GO:0008661|GO:0016114 KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 TOPB45_1414 83d5ca755d483271decd1227c486fb0a 621 SUPERFAMILY SSF52518 312 500 1.14E-60 T 13-10-2018 IPR029061 Thiamin diphosphate-binding fold TOPB45_1097 e4d55ae940e51b5a2306ec4e84ce5c6a 798 Gene3D G3DSA:3.40.50.300 275 497 8.3E-15 T 13-10-2018 TOPB45_1097 e4d55ae940e51b5a2306ec4e84ce5c6a 798 SUPERFAMILY SSF52540 270 498 6.84E-15 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0563 98a7fba13ee9244e41dba2d38e672dfa 565 TIGRFAM TIGR00409 proS_fam_II: proline--tRNA ligase 1 557 6.8E-219 T 13-10-2018 IPR004500 Prolyl-tRNA synthetase, class IIa, bacterial-type GO:0004827|GO:0005524|GO:0005737|GO:0006433 KEGG: 00970+6.1.1.15 TOPB45_0563 98a7fba13ee9244e41dba2d38e672dfa 565 SUPERFAMILY SSF55826 218 384 2.22E-34 T 13-10-2018 IPR036754 YbaK/aminoacyl-tRNA synthetase-associated domain superfamily GO:0002161 KEGG: 00970+6.1.1.15 TOPB45_0563 98a7fba13ee9244e41dba2d38e672dfa 565 SUPERFAMILY SSF55681 9 474 6.01E-102 T 13-10-2018 TOPB45_0563 98a7fba13ee9244e41dba2d38e672dfa 565 Pfam PF03129 Anticodon binding domain 471 559 2.3E-18 T 13-10-2018 IPR004154 Anticodon-binding TOPB45_0563 98a7fba13ee9244e41dba2d38e672dfa 565 Gene3D G3DSA:3.90.960.10 240 385 5.1E-246 T 13-10-2018 IPR036754 YbaK/aminoacyl-tRNA synthetase-associated domain superfamily GO:0002161 KEGG: 00970+6.1.1.15 TOPB45_0563 98a7fba13ee9244e41dba2d38e672dfa 565 SUPERFAMILY SSF52954 460 563 2.87E-28 T 13-10-2018 TOPB45_0563 98a7fba13ee9244e41dba2d38e672dfa 565 Pfam PF00587 tRNA synthetase class II core domain (G, H, P, S and T) 95 455 2.7E-46 T 13-10-2018 IPR002314 Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) GO:0000166|GO:0004812|GO:0005524|GO:0006418 TOPB45_0563 98a7fba13ee9244e41dba2d38e672dfa 565 Gene3D G3DSA:3.30.930.10 11 461 5.1E-246 T 13-10-2018 TOPB45_0563 98a7fba13ee9244e41dba2d38e672dfa 565 PRINTS PR01046 Prolyl-tRNA synthetase signature 68 86 6.3E-19 T 13-10-2018 IPR002316 Proline-tRNA ligase, class IIa GO:0004827|GO:0005524|GO:0005737|GO:0006433 KEGG: 00970+6.1.1.15|Reactome: R-HSA-379726 TOPB45_0563 98a7fba13ee9244e41dba2d38e672dfa 565 PRINTS PR01046 Prolyl-tRNA synthetase signature 144 155 6.3E-19 T 13-10-2018 IPR002316 Proline-tRNA ligase, class IIa GO:0004827|GO:0005524|GO:0005737|GO:0006433 KEGG: 00970+6.1.1.15|Reactome: R-HSA-379726 TOPB45_0563 98a7fba13ee9244e41dba2d38e672dfa 565 PRINTS PR01046 Prolyl-tRNA synthetase signature 134 142 6.3E-19 T 13-10-2018 IPR002316 Proline-tRNA ligase, class IIa GO:0004827|GO:0005524|GO:0005737|GO:0006433 KEGG: 00970+6.1.1.15|Reactome: R-HSA-379726 TOPB45_0563 98a7fba13ee9244e41dba2d38e672dfa 565 PRINTS PR01046 Prolyl-tRNA synthetase signature 104 115 6.3E-19 T 13-10-2018 IPR002316 Proline-tRNA ligase, class IIa GO:0004827|GO:0005524|GO:0005737|GO:0006433 KEGG: 00970+6.1.1.15|Reactome: R-HSA-379726 TOPB45_0563 98a7fba13ee9244e41dba2d38e672dfa 565 Gene3D G3DSA:3.40.50.800 4 545 5.1E-246 T 13-10-2018 IPR036621 Anticodon-binding domain superfamily TOPB45_0563 98a7fba13ee9244e41dba2d38e672dfa 565 PIRSF PIRSF001535 1 565 2.0E-254 T 13-10-2018 IPR023717 Prolyl-tRNA synthetase, class IIa, type 1 GO:0004827|GO:0005524|GO:0005737|GO:0006433 KEGG: 00970+6.1.1.15 TOPB45_0563 98a7fba13ee9244e41dba2d38e672dfa 565 Pfam PF04073 Aminoacyl-tRNA editing domain 257 370 8.0E-33 T 13-10-2018 IPR007214 YbaK/aminoacyl-tRNA synthetase-associated domain GO:0002161 KEGG: 00970+6.1.1.15 TOPB45_0563 98a7fba13ee9244e41dba2d38e672dfa 565 Hamap MF_01569 Proline--tRNA ligase [proS]. 1 562 40.578 T 13-10-2018 IPR023717 Prolyl-tRNA synthetase, class IIa, type 1 GO:0004827|GO:0005524|GO:0005737|GO:0006433 KEGG: 00970+6.1.1.15 TOPB45_0288 c07322dc698e8057ee1544723e97e7fc 537 Gene3D G3DSA:1.20.1720.10 26 233 1.6E-43 T 13-10-2018 TOPB45_0288 c07322dc698e8057ee1544723e97e7fc 537 TIGRFAM TIGR00711 efflux_EmrB: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family 23 512 1.2E-128 T 13-10-2018 IPR004638 Drug resistance transporter EmrB/QacA subfamily GO:0016021|GO:0022857|GO:0055085 TOPB45_0288 c07322dc698e8057ee1544723e97e7fc 537 SUPERFAMILY SSF103473 17 517 2.09E-55 T 13-10-2018 IPR036259 MFS transporter superfamily TOPB45_0288 c07322dc698e8057ee1544723e97e7fc 537 PRINTS PR01036 Tetracycline resistance protein TetB signature 28 52 3.1E-6 T 13-10-2018 TOPB45_0288 c07322dc698e8057ee1544723e97e7fc 537 PRINTS PR01036 Tetracycline resistance protein TetB signature 119 139 3.1E-6 T 13-10-2018 TOPB45_0288 c07322dc698e8057ee1544723e97e7fc 537 PRINTS PR01036 Tetracycline resistance protein TetB signature 149 173 3.1E-6 T 13-10-2018 TOPB45_0288 c07322dc698e8057ee1544723e97e7fc 537 Pfam PF07690 Major Facilitator Superfamily 29 427 1.6E-43 T 13-10-2018 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TOPB45_0786 8366a1b3bbdec788ac1ee84a848e6967 420 SMART SM01086 315 409 3.4E-33 T 13-10-2018 IPR019489 Clp ATPase, C-terminal TOPB45_0786 8366a1b3bbdec788ac1ee84a848e6967 420 Gene3D G3DSA:3.40.50.300 53 313 7.1E-111 T 13-10-2018 TOPB45_0786 8366a1b3bbdec788ac1ee84a848e6967 420 Pfam PF06689 ClpX C4-type zinc finger 9 45 6.1E-20 T 13-10-2018 IPR010603 Zinc finger, ClpX C4-type GO:0008270|GO:0046983 TOPB45_0786 8366a1b3bbdec788ac1ee84a848e6967 420 TIGRFAM TIGR00382 clpX: ATP-dependent Clp protease, ATP-binding subunit ClpX 8 410 1.9E-198 T 13-10-2018 IPR004487 Clp protease, ATP-binding subunit ClpX GO:0005524|GO:0006457|GO:0051082 TOPB45_0786 8366a1b3bbdec788ac1ee84a848e6967 420 SMART SM00382 111 268 1.3E-8 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_0786 8366a1b3bbdec788ac1ee84a848e6967 420 Gene3D G3DSA:1.10.8.60 314 420 6.3E-40 T 13-10-2018 TOPB45_0786 8366a1b3bbdec788ac1ee84a848e6967 420 Hamap MF_00175 ATP-dependent Clp protease ATP-binding subunit ClpX [clpX]. 1 413 52.817 T 13-10-2018 IPR004487 Clp protease, ATP-binding subunit ClpX GO:0005524|GO:0006457|GO:0051082 TOPB45_0786 8366a1b3bbdec788ac1ee84a848e6967 420 SUPERFAMILY SSF57716 8 43 2.0E-11 T 13-10-2018 TOPB45_0786 8366a1b3bbdec788ac1ee84a848e6967 420 SMART SM00994 7 46 2.6E-23 T 13-10-2018 IPR010603 Zinc finger, ClpX C4-type GO:0008270|GO:0046983 TOPB45_0786 8366a1b3bbdec788ac1ee84a848e6967 420 Pfam PF07724 AAA domain (Cdc48 subfamily) 111 309 8.5E-48 T 13-10-2018 IPR003959 ATPase, AAA-type, core GO:0005524 TOPB45_0786 8366a1b3bbdec788ac1ee84a848e6967 420 SUPERFAMILY SSF52540 60 399 1.04E-72 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0786 8366a1b3bbdec788ac1ee84a848e6967 420 Gene3D G3DSA:3.30.50.30 2 47 4.9E-20 T 13-10-2018 IPR038366 Zinc finger, ClpX C4-type superfamily TOPB45_0786 8366a1b3bbdec788ac1ee84a848e6967 420 Pfam PF10431 C-terminal, D2-small domain, of ClpB protein 315 393 1.3E-15 T 13-10-2018 IPR019489 Clp ATPase, C-terminal TOPB45_1295 c85b35ea0b9070848026c90d98e5da0b 183 Gene3D G3DSA:3.40.470.10 1 183 9.5E-63 T 13-10-2018 IPR036895 Uracil-DNA glycosylase-like domain superfamily Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 TOPB45_1295 c85b35ea0b9070848026c90d98e5da0b 183 SMART SM00987 29 176 1.7E-31 T 13-10-2018 TOPB45_1295 c85b35ea0b9070848026c90d98e5da0b 183 SMART SM00986 29 176 1.7E-31 T 13-10-2018 IPR005122 Uracil-DNA glycosylase-like Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 TOPB45_1295 c85b35ea0b9070848026c90d98e5da0b 183 Pfam PF03167 Uracil DNA glycosylase superfamily 29 164 1.2E-38 T 13-10-2018 IPR005122 Uracil-DNA glycosylase-like Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 TOPB45_1295 c85b35ea0b9070848026c90d98e5da0b 183 SUPERFAMILY SSF52141 3 182 8.83E-54 T 13-10-2018 IPR036895 Uracil-DNA glycosylase-like domain superfamily Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 TOPB45_1295 c85b35ea0b9070848026c90d98e5da0b 183 TIGRFAM TIGR00758 UDG_fam4: uracil-DNA glycosylase, family 4 15 182 1.9E-52 T 13-10-2018 IPR005273 Uracil-DNA glycosylase family 4 TOPB45_1328 e017ce0e851a743e1524af6e02a6e4de 340 SUPERFAMILY SSF52540 138 324 1.54E-15 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1328 e017ce0e851a743e1524af6e02a6e4de 340 Pfam PF00448 SRP54-type protein, GTPase domain 143 326 1.3E-15 T 13-10-2018 IPR000897 Signal recognition particle, SRP54 subunit, GTPase domain GO:0005525|GO:0006614 Reactome: R-HSA-1799339 TOPB45_1328 e017ce0e851a743e1524af6e02a6e4de 340 Gene3D G3DSA:1.20.120.1380 124 319 4.8E-28 T 13-10-2018 TOPB45_1328 e017ce0e851a743e1524af6e02a6e4de 340 Gene3D G3DSA:3.40.50.300 136 317 4.8E-28 T 13-10-2018 TOPB45_1328 e017ce0e851a743e1524af6e02a6e4de 340 SMART SM00962 141 329 4.0E-8 T 13-10-2018 IPR000897 Signal recognition particle, SRP54 subunit, GTPase domain GO:0005525|GO:0006614 Reactome: R-HSA-1799339 TOPB45_0079 184525adc6430c86c6a9b3cd7154688b 515 Gene3D G3DSA:3.40.50.620 200 395 2.1E-77 T 13-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TOPB45_0079 184525adc6430c86c6a9b3cd7154688b 515 PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature 48 62 5.2E-5 T 13-10-2018 TOPB45_0079 184525adc6430c86c6a9b3cd7154688b 515 PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature 7 21 5.2E-5 T 13-10-2018 TOPB45_0079 184525adc6430c86c6a9b3cd7154688b 515 PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature 78 94 5.2E-5 T 13-10-2018 TOPB45_0079 184525adc6430c86c6a9b3cd7154688b 515 PRINTS PR00096 Glutamine amidotransferase superfamily signature 51 60 1.3E-7 T 13-10-2018 TOPB45_0079 184525adc6430c86c6a9b3cd7154688b 515 PRINTS PR00096 Glutamine amidotransferase superfamily signature 78 89 1.3E-7 T 13-10-2018 TOPB45_0079 184525adc6430c86c6a9b3cd7154688b 515 PRINTS PR00096 Glutamine amidotransferase superfamily signature 168 181 1.3E-7 T 13-10-2018 TOPB45_0079 184525adc6430c86c6a9b3cd7154688b 515 TIGRFAM TIGR00884 guaA_Cterm: GMP synthase (glutamine-hydrolyzing), C-terminal domain 204 515 1.6E-149 T 13-10-2018 IPR001674 GMP synthase, C-terminal GO:0003922|GO:0005524|GO:0006164|GO:0006177 KEGG: 00230+6.3.5.2|KEGG: 00983+6.3.5.2|MetaCyc: PWY-7221|Reactome: R-HSA-73817 TOPB45_0079 184525adc6430c86c6a9b3cd7154688b 515 Pfam PF00958 GMP synthase C terminal domain 423 514 4.6E-45 T 13-10-2018 IPR001674 GMP synthase, C-terminal GO:0003922|GO:0005524|GO:0006164|GO:0006177 KEGG: 00230+6.3.5.2|KEGG: 00983+6.3.5.2|MetaCyc: PWY-7221|Reactome: R-HSA-73817 TOPB45_0079 184525adc6430c86c6a9b3cd7154688b 515 Pfam PF00117 Glutamine amidotransferase class-I 9 191 3.2E-40 T 13-10-2018 IPR017926 Glutamine amidotransferase TOPB45_0079 184525adc6430c86c6a9b3cd7154688b 515 TIGRFAM TIGR00888 guaA_Nterm: GMP synthase (glutamine-hydrolyzing), N-terminal domain 7 196 1.6E-78 T 13-10-2018 IPR004739 GMP synthase, glutamine amidotransferase GO:0003922|GO:0005524|GO:0006177 KEGG: 00230+6.3.5.2|KEGG: 00983+6.3.5.2|MetaCyc: PWY-7221|Reactome: R-HSA-73817 TOPB45_0079 184525adc6430c86c6a9b3cd7154688b 515 PRINTS PR00097 Anthranilate synthase component II signature 78 89 4.5E-7 T 13-10-2018 TOPB45_0079 184525adc6430c86c6a9b3cd7154688b 515 PRINTS PR00097 Anthranilate synthase component II signature 168 181 4.5E-7 T 13-10-2018 TOPB45_0079 184525adc6430c86c6a9b3cd7154688b 515 PRINTS PR00097 Anthranilate synthase component II signature 51 60 4.5E-7 T 13-10-2018 TOPB45_0079 184525adc6430c86c6a9b3cd7154688b 515 Gene3D G3DSA:3.40.50.880 2 196 3.8E-60 T 13-10-2018 IPR029062 Class I glutamine amidotransferase-like TOPB45_0079 184525adc6430c86c6a9b3cd7154688b 515 SUPERFAMILY SSF52402 184 436 1.76E-58 T 13-10-2018 TOPB45_0079 184525adc6430c86c6a9b3cd7154688b 515 SUPERFAMILY SSF54810 395 515 3.01E-53 T 13-10-2018 TOPB45_0079 184525adc6430c86c6a9b3cd7154688b 515 SUPERFAMILY SSF52317 3 229 1.62E-57 T 13-10-2018 IPR029062 Class I glutamine amidotransferase-like TOPB45_0079 184525adc6430c86c6a9b3cd7154688b 515 Hamap MF_00344 GMP synthase [glutamine-hydrolyzing] [guaA]. 4 515 55.112 T 13-10-2018 IPR022955 GMP synthase GO:0003922|GO:0006177 KEGG: 00230+6.3.5.2|KEGG: 00983+6.3.5.2|MetaCyc: PWY-7221 TOPB45_0079 184525adc6430c86c6a9b3cd7154688b 515 Pfam PF02540 NAD synthase 205 293 9.6E-8 T 13-10-2018 IPR022310 NAD/GMP synthase TOPB45_0079 184525adc6430c86c6a9b3cd7154688b 515 Gene3D G3DSA:3.30.300.10 396 515 5.5E-54 T 13-10-2018 TOPB45_0349 c86c6779dd8bf24f61ceef5f9947ba39 420 Gene3D G3DSA:3.40.50.2000 55 397 4.9E-10 T 13-10-2018 TOPB45_0349 c86c6779dd8bf24f61ceef5f9947ba39 420 Pfam PF13692 Glycosyl transferases group 1 240 367 7.2E-8 T 13-10-2018 TOPB45_0349 c86c6779dd8bf24f61ceef5f9947ba39 420 Gene3D G3DSA:3.40.50.2000 215 391 4.9E-10 T 13-10-2018 TOPB45_0349 c86c6779dd8bf24f61ceef5f9947ba39 420 SUPERFAMILY SSF53756 12 401 1.88E-16 T 13-10-2018 TOPB45_1417 0671eaf5d4c19cc95f1d975a9be702fd 456 Hamap MF_00378 Exodeoxyribonuclease 7 large subunit [xseA]. 16 452 22.118 T 13-10-2018 IPR003753 Exonuclease VII, large subunit GO:0006308|GO:0008855|GO:0009318 TOPB45_1417 0671eaf5d4c19cc95f1d975a9be702fd 456 Pfam PF02601 Exonuclease VII, large subunit 134 448 3.5E-86 T 13-10-2018 IPR020579 Exonuclease VII, large subunit, C-terminal GO:0008855 TOPB45_1417 0671eaf5d4c19cc95f1d975a9be702fd 456 TIGRFAM TIGR00237 xseA: exodeoxyribonuclease VII, large subunit 20 452 2.3E-116 T 13-10-2018 IPR003753 Exonuclease VII, large subunit GO:0006308|GO:0008855|GO:0009318 TOPB45_1417 0671eaf5d4c19cc95f1d975a9be702fd 456 Pfam PF13742 OB-fold nucleic acid binding domain 19 112 7.2E-22 T 13-10-2018 IPR025824 OB-fold nucleic acid binding domain GO:0003676 TOPB45_1516 c5bdcaf0dc8bfbb9a7f6c2b100ea4225 340 Gene3D G3DSA:3.40.50.620 1 198 5.6E-64 T 13-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TOPB45_1516 c5bdcaf0dc8bfbb9a7f6c2b100ea4225 340 SUPERFAMILY SSF52402 1 229 4.61E-40 T 13-10-2018 TOPB45_1516 c5bdcaf0dc8bfbb9a7f6c2b100ea4225 340 Pfam PF03054 tRNA methyl transferase 1 335 3.6E-103 T 13-10-2018 TOPB45_1516 c5bdcaf0dc8bfbb9a7f6c2b100ea4225 340 Hamap MF_00144 tRNA-specific 2-thiouridylase MnmA [mnmA]. 1 336 34.719 T 13-10-2018 IPR004506 tRNA-specific 2-thiouridylase GO:0008033|GO:0016740 MetaCyc: PWY-7887|MetaCyc: PWY-7892|Reactome: R-HSA-6787450 TOPB45_1516 c5bdcaf0dc8bfbb9a7f6c2b100ea4225 340 TIGRFAM TIGR00420 trmU: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase 1 335 1.2E-100 T 13-10-2018 IPR004506 tRNA-specific 2-thiouridylase GO:0008033|GO:0016740 MetaCyc: PWY-7887|MetaCyc: PWY-7892|Reactome: R-HSA-6787450 TOPB45_1516 c5bdcaf0dc8bfbb9a7f6c2b100ea4225 340 Gene3D G3DSA:2.30.30.280 199 259 5.7E-15 T 13-10-2018 IPR023382 Adenine nucleotide alpha hydrolase-like domains GO:0016783 MetaCyc: PWY-7887|MetaCyc: PWY-7892|Reactome: R-HSA-6787450 TOPB45_1516 c5bdcaf0dc8bfbb9a7f6c2b100ea4225 340 Gene3D G3DSA:2.40.30.10 260 340 1.4E-15 T 13-10-2018 TOPB45_0602 95d555fc895b2faf49744ababc6f89b8 333 SUPERFAMILY SSF51735 1 178 1.06E-41 T 13-10-2018 IPR036291 NAD(P)-binding domain superfamily TOPB45_0602 95d555fc895b2faf49744ababc6f89b8 333 PIRSF PIRSF000114 1 330 4.7E-106 T 13-10-2018 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|MetaCyc: PWY-7902|Reactome: R-HSA-1483166 TOPB45_0602 95d555fc895b2faf49744ababc6f89b8 333 Pfam PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 178 317 4.6E-51 T 13-10-2018 IPR006109 Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal GO:0004367|GO:0005975|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|MetaCyc: PWY-7902|Reactome: R-HSA-1483166 TOPB45_0602 95d555fc895b2faf49744ababc6f89b8 333 Hamap MF_00394 Glycerol-3-phosphate dehydrogenase [NAD(P)+] [gpsA]. 1 320 35.026 T 13-10-2018 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|MetaCyc: PWY-7902|Reactome: R-HSA-1483166 TOPB45_0602 95d555fc895b2faf49744ababc6f89b8 333 ProSitePatterns PS00957 NAD-dependent glycerol-3-phosphate dehydrogenase signature. 186 207 - T 13-10-2018 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|MetaCyc: PWY-7902|Reactome: R-HSA-1483166 TOPB45_0602 95d555fc895b2faf49744ababc6f89b8 333 SUPERFAMILY SSF48179 177 329 1.53E-54 T 13-10-2018 IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily GO:0055114 TOPB45_0602 95d555fc895b2faf49744ababc6f89b8 333 Gene3D G3DSA:3.40.50.720 1 185 6.8E-56 T 13-10-2018 TOPB45_0602 95d555fc895b2faf49744ababc6f89b8 333 PRINTS PR00077 NAD-dependent glycerol-3-phosphate dehydrogenase signature 171 195 4.4E-42 T 13-10-2018 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|MetaCyc: PWY-7902|Reactome: R-HSA-1483166 TOPB45_0602 95d555fc895b2faf49744ababc6f89b8 333 PRINTS PR00077 NAD-dependent glycerol-3-phosphate dehydrogenase signature 131 151 4.4E-42 T 13-10-2018 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|MetaCyc: PWY-7902|Reactome: R-HSA-1483166 TOPB45_0602 95d555fc895b2faf49744ababc6f89b8 333 PRINTS PR00077 NAD-dependent glycerol-3-phosphate dehydrogenase signature 55 82 4.4E-42 T 13-10-2018 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|MetaCyc: PWY-7902|Reactome: R-HSA-1483166 TOPB45_0602 95d555fc895b2faf49744ababc6f89b8 333 PRINTS PR00077 NAD-dependent glycerol-3-phosphate dehydrogenase signature 5 22 4.4E-42 T 13-10-2018 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|MetaCyc: PWY-7902|Reactome: R-HSA-1483166 TOPB45_0602 95d555fc895b2faf49744ababc6f89b8 333 PRINTS PR00077 NAD-dependent glycerol-3-phosphate dehydrogenase signature 196 220 4.4E-42 T 13-10-2018 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|MetaCyc: PWY-7902|Reactome: R-HSA-1483166 TOPB45_0602 95d555fc895b2faf49744ababc6f89b8 333 PRINTS PR00077 NAD-dependent glycerol-3-phosphate dehydrogenase signature 236 253 4.4E-42 T 13-10-2018 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|MetaCyc: PWY-7902|Reactome: R-HSA-1483166 TOPB45_0602 95d555fc895b2faf49744ababc6f89b8 333 Pfam PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 2 157 1.5E-43 T 13-10-2018 IPR011128 Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal GO:0016616|GO:0046168|GO:0051287|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|MetaCyc: PWY-7902|Reactome: R-HSA-1483166 TOPB45_0602 95d555fc895b2faf49744ababc6f89b8 333 Gene3D G3DSA:1.10.1040.10 187 332 9.1E-53 T 13-10-2018 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 TOPB45_0122 cfe510aa688b22581e54f4ef46d0a1e4 923 SUPERFAMILY SSF81767 227 350 8.11E-50 T 13-10-2018 IPR036670 SecA, preprotein cross-linking domain superfamily GO:0016020|GO:0017038 TOPB45_0122 cfe510aa688b22581e54f4ef46d0a1e4 923 Pfam PF07516 SecA Wing and Scaffold domain 632 839 9.7E-64 T 13-10-2018 IPR011116 SecA Wing/Scaffold GO:0016020|GO:0017038 TOPB45_0122 cfe510aa688b22581e54f4ef46d0a1e4 923 Gene3D G3DSA:1.10.3060.10 636 842 1.8E-66 T 13-10-2018 TOPB45_0122 cfe510aa688b22581e54f4ef46d0a1e4 923 ProSitePatterns PS01312 SecA family signature. 482 497 - T 13-10-2018 IPR020937 SecA conserved site GO:0006605|GO:0006886|GO:0016020 TOPB45_0122 cfe510aa688b22581e54f4ef46d0a1e4 923 SUPERFAMILY SSF81886 635 899 1.7E-73 T 13-10-2018 IPR036266 SecA, Wing/Scaffold superfamily TOPB45_0122 cfe510aa688b22581e54f4ef46d0a1e4 923 Pfam PF07517 SecA DEAD-like domain 7 384 1.6E-141 T 13-10-2018 IPR011115 SecA DEAD-like, N-terminal GO:0005524|GO:0016020|GO:0017038 TOPB45_0122 cfe510aa688b22581e54f4ef46d0a1e4 923 Gene3D G3DSA:3.40.50.300 22 397 2.0E-195 T 13-10-2018 TOPB45_0122 cfe510aa688b22581e54f4ef46d0a1e4 923 PRINTS PR00906 SecA protein signature 101 115 5.7E-73 T 13-10-2018 IPR000185 Protein translocase subunit SecA GO:0005524|GO:0006605|GO:0006886 TOPB45_0122 cfe510aa688b22581e54f4ef46d0a1e4 923 PRINTS PR00906 SecA protein signature 395 408 5.7E-73 T 13-10-2018 IPR000185 Protein translocase subunit SecA GO:0005524|GO:0006605|GO:0006886 TOPB45_0122 cfe510aa688b22581e54f4ef46d0a1e4 923 PRINTS PR00906 SecA protein signature 63 87 5.7E-73 T 13-10-2018 IPR000185 Protein translocase subunit SecA GO:0005524|GO:0006605|GO:0006886 TOPB45_0122 cfe510aa688b22581e54f4ef46d0a1e4 923 PRINTS PR00906 SecA protein signature 321 343 5.7E-73 T 13-10-2018 IPR000185 Protein translocase subunit SecA GO:0005524|GO:0006605|GO:0006886 TOPB45_0122 cfe510aa688b22581e54f4ef46d0a1e4 923 PRINTS PR00906 SecA protein signature 170 190 5.7E-73 T 13-10-2018 IPR000185 Protein translocase subunit SecA GO:0005524|GO:0006605|GO:0006886 TOPB45_0122 cfe510aa688b22581e54f4ef46d0a1e4 923 PRINTS PR00906 SecA protein signature 358 375 5.7E-73 T 13-10-2018 IPR000185 Protein translocase subunit SecA GO:0005524|GO:0006605|GO:0006886 TOPB45_0122 cfe510aa688b22581e54f4ef46d0a1e4 923 PRINTS PR00906 SecA protein signature 117 127 5.7E-73 T 13-10-2018 IPR000185 Protein translocase subunit SecA GO:0005524|GO:0006605|GO:0006886 TOPB45_0122 cfe510aa688b22581e54f4ef46d0a1e4 923 Pfam PF02810 SEC-C motif 891 909 6.8E-10 T 13-10-2018 IPR004027 SEC-C motif TOPB45_0122 cfe510aa688b22581e54f4ef46d0a1e4 923 SUPERFAMILY SSF52540 398 633 1.52E-55 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0122 cfe510aa688b22581e54f4ef46d0a1e4 923 SMART SM00958 228 340 5.5E-76 T 13-10-2018 IPR011130 SecA, preprotein cross-linking domain GO:0016020|GO:0017038 TOPB45_0122 cfe510aa688b22581e54f4ef46d0a1e4 923 Pfam PF01043 SecA preprotein cross-linking domain 232 340 1.1E-44 T 13-10-2018 IPR011130 SecA, preprotein cross-linking domain GO:0016020|GO:0017038 TOPB45_0122 cfe510aa688b22581e54f4ef46d0a1e4 923 Gene3D G3DSA:3.90.1440.10 229 350 2.0E-195 T 13-10-2018 TOPB45_0122 cfe510aa688b22581e54f4ef46d0a1e4 923 TIGRFAM TIGR00963 secA: preprotein translocase, SecA subunit 28 828 0.0 T 13-10-2018 IPR000185 Protein translocase subunit SecA GO:0005524|GO:0006605|GO:0006886 TOPB45_0122 cfe510aa688b22581e54f4ef46d0a1e4 923 SMART SM00957 6 384 0.0 T 13-10-2018 IPR011115 SecA DEAD-like, N-terminal GO:0005524|GO:0016020|GO:0017038 TOPB45_0122 cfe510aa688b22581e54f4ef46d0a1e4 923 Hamap MF_01382 Protein translocase subunit SecA [secA]. 5 842 20.894 T 13-10-2018 IPR000185 Protein translocase subunit SecA GO:0005524|GO:0006605|GO:0006886 TOPB45_0122 cfe510aa688b22581e54f4ef46d0a1e4 923 SUPERFAMILY SSF52540 5 397 8.26E-90 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0122 cfe510aa688b22581e54f4ef46d0a1e4 923 Gene3D G3DSA:3.40.50.300 399 634 1.3E-93 T 13-10-2018 TOPB45_0122 cfe510aa688b22581e54f4ef46d0a1e4 923 Gene3D G3DSA:3.10.450.50 843 911 2.6E-10 T 13-10-2018 TOPB45_0846 6a4f3c11e76e84e37323b484e01200a4 124 TIGRFAM TIGR02532 IV_pilin_GFxxxE: prepilin-type N-terminal cleavage/methylation domain 4 26 1.7E-7 T 13-10-2018 IPR012902 Prokaryotic N-terminal methylation site TOPB45_0846 6a4f3c11e76e84e37323b484e01200a4 124 Pfam PF07963 Prokaryotic N-terminal methylation motif 2 25 2.6E-7 T 13-10-2018 IPR012902 Prokaryotic N-terminal methylation site TOPB45_0846 6a4f3c11e76e84e37323b484e01200a4 124 SUPERFAMILY SSF54523 6 100 1.18E-11 T 13-10-2018 TOPB45_0846 6a4f3c11e76e84e37323b484e01200a4 124 Gene3D G3DSA:3.30.700.10 6 124 4.1E-13 T 13-10-2018 TOPB45_0781 d0a43777759056b93b8aff570d962235 321 SUPERFAMILY SSF47789 246 318 3.01E-25 T 13-10-2018 TOPB45_0781 d0a43777759056b93b8aff570d962235 321 Hamap MF_00059 DNA-directed RNA polymerase subunit alpha [rpoA]. 1 312 36.542 T 13-10-2018 IPR011773 DNA-directed RNA polymerase, alpha subunit GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TOPB45_0781 d0a43777759056b93b8aff570d962235 321 Gene3D G3DSA:3.30.1360.10 22 223 1.7E-86 T 13-10-2018 IPR036603 RNA polymerase, RBP11-like subunit GO:0006351|GO:0046983 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TOPB45_0781 d0a43777759056b93b8aff570d962235 321 Pfam PF03118 Bacterial RNA polymerase, alpha chain C terminal domain 243 303 8.9E-26 T 13-10-2018 IPR011260 RNA polymerase, alpha subunit, C-terminal GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TOPB45_0781 d0a43777759056b93b8aff570d962235 321 SUPERFAMILY SSF55257 11 227 7.85E-31 T 13-10-2018 IPR036603 RNA polymerase, RBP11-like subunit GO:0006351|GO:0046983 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TOPB45_0781 d0a43777759056b93b8aff570d962235 321 Gene3D G3DSA:1.10.150.20 241 321 9.2E-31 T 13-10-2018 TOPB45_0781 d0a43777759056b93b8aff570d962235 321 SMART SM00662 24 229 1.8E-80 T 13-10-2018 IPR011263 DNA-directed RNA polymerase, RpoA/D/Rpb3-type GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TOPB45_0781 d0a43777759056b93b8aff570d962235 321 TIGRFAM TIGR02027 rpoA: DNA-directed RNA polymerase, alpha subunit 24 311 2.6E-112 T 13-10-2018 IPR011773 DNA-directed RNA polymerase, alpha subunit GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TOPB45_0781 d0a43777759056b93b8aff570d962235 321 ProDom PD001179 RNA POLYMERASE ALPHA DNA-DIRECTED SUBUNIT CHAIN NUCLEOTIDYLTRANSFERASE TRANSFERASE TRANSCRIPTION TRANSCRIPTASE 252 318 2.0E-15 T 13-10-2018 IPR011260 RNA polymerase, alpha subunit, C-terminal GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TOPB45_0781 d0a43777759056b93b8aff570d962235 321 SUPERFAMILY SSF56553 54 173 9.42E-41 T 13-10-2018 IPR036643 DNA-directed RNA polymerase, insert domain superfamily KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TOPB45_0781 d0a43777759056b93b8aff570d962235 321 Pfam PF01193 RNA polymerase Rpb3/Rpb11 dimerisation domain 30 223 6.0E-26 T 13-10-2018 IPR011263 DNA-directed RNA polymerase, RpoA/D/Rpb3-type GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TOPB45_0781 d0a43777759056b93b8aff570d962235 321 Pfam PF01000 RNA polymerase Rpb3/RpoA insert domain 65 157 4.4E-21 T 13-10-2018 IPR011262 DNA-directed RNA polymerase, insert domain GO:0003899|GO:0006351|GO:0046983 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TOPB45_0781 d0a43777759056b93b8aff570d962235 321 Gene3D G3DSA:2.170.120.12 54 172 1.7E-86 T 13-10-2018 IPR036643 DNA-directed RNA polymerase, insert domain superfamily KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TOPB45_0547 7a60e093b67a3a186e8a45eac1d0b648 68 Pfam PF01632 Ribosomal protein L35 5 63 4.3E-20 T 13-10-2018 IPR021137 Ribosomal protein L35 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0547 7a60e093b67a3a186e8a45eac1d0b648 68 PRINTS PR00064 Ribosomal protein L35 signature 38 56 1.3E-17 T 13-10-2018 IPR001706 Ribosomal protein L35, non-mitochondrial GO:0003735|GO:0005840|GO:0006412 TOPB45_0547 7a60e093b67a3a186e8a45eac1d0b648 68 PRINTS PR00064 Ribosomal protein L35 signature 5 22 1.3E-17 T 13-10-2018 IPR001706 Ribosomal protein L35, non-mitochondrial GO:0003735|GO:0005840|GO:0006412 TOPB45_0547 7a60e093b67a3a186e8a45eac1d0b648 68 PRINTS PR00064 Ribosomal protein L35 signature 23 37 1.3E-17 T 13-10-2018 IPR001706 Ribosomal protein L35, non-mitochondrial GO:0003735|GO:0005840|GO:0006412 TOPB45_0547 7a60e093b67a3a186e8a45eac1d0b648 68 TIGRFAM TIGR00001 rpmI_bact: ribosomal protein bL35 5 66 6.2E-24 T 13-10-2018 IPR001706 Ribosomal protein L35, non-mitochondrial GO:0003735|GO:0005840|GO:0006412 TOPB45_0547 7a60e093b67a3a186e8a45eac1d0b648 68 ProSitePatterns PS00936 Ribosomal protein L35 signature. 7 33 - T 13-10-2018 IPR018265 Ribosomal protein L35, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0547 7a60e093b67a3a186e8a45eac1d0b648 68 SUPERFAMILY SSF143034 5 66 4.97E-20 T 13-10-2018 IPR037229 Ribosomal protein L35 superfamily Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0547 7a60e093b67a3a186e8a45eac1d0b648 68 Hamap MF_00514 50S ribosomal protein L35 [rpmI]. 3 66 16.492 T 13-10-2018 IPR001706 Ribosomal protein L35, non-mitochondrial GO:0003735|GO:0005840|GO:0006412 TOPB45_0547 7a60e093b67a3a186e8a45eac1d0b648 68 Gene3D G3DSA:2.40.50.530 5 67 1.3E-20 T 13-10-2018 TOPB45_1062 ae46cd2b8831cd7739dcc00eb7d5009d 541 Gene3D G3DSA:1.10.290.10 249 369 1.8E-118 T 13-10-2018 IPR013826 DNA topoisomerase, type IA, central region, subdomain 3 TOPB45_1062 ae46cd2b8831cd7739dcc00eb7d5009d 541 Gene3D G3DSA:1.10.460.10 137 531 1.8E-118 T 13-10-2018 IPR013824 DNA topoisomerase, type IA, central region, subdomain 1 TOPB45_1062 ae46cd2b8831cd7739dcc00eb7d5009d 541 Pfam PF01131 DNA topoisomerase 127 530 3.2E-106 T 13-10-2018 IPR013497 DNA topoisomerase, type IA, central GO:0003677|GO:0003916|GO:0006265 TOPB45_1062 ae46cd2b8831cd7739dcc00eb7d5009d 541 SMART SM00436 103 191 8.0E-35 T 13-10-2018 IPR003601 DNA topoisomerase, type IA, domain 2 GO:0003677|GO:0003916|GO:0006265 TOPB45_1062 ae46cd2b8831cd7739dcc00eb7d5009d 541 ProSitePatterns PS00396 Prokaryotic DNA topoisomerase I active site. 278 292 - T 13-10-2018 IPR023406 DNA topoisomerase, type IA, active site GO:0003917 TOPB45_1062 ae46cd2b8831cd7739dcc00eb7d5009d 541 PRINTS PR00417 Prokaryotic DNA topoisomerase I signature 456 470 9.2E-35 T 13-10-2018 IPR013497 DNA topoisomerase, type IA, central GO:0003677|GO:0003916|GO:0006265 TOPB45_1062 ae46cd2b8831cd7739dcc00eb7d5009d 541 PRINTS PR00417 Prokaryotic DNA topoisomerase I signature 74 87 9.2E-35 T 13-10-2018 IPR013497 DNA topoisomerase, type IA, central GO:0003677|GO:0003916|GO:0006265 TOPB45_1062 ae46cd2b8831cd7739dcc00eb7d5009d 541 PRINTS PR00417 Prokaryotic DNA topoisomerase I signature 355 371 9.2E-35 T 13-10-2018 IPR013497 DNA topoisomerase, type IA, central GO:0003677|GO:0003916|GO:0006265 TOPB45_1062 ae46cd2b8831cd7739dcc00eb7d5009d 541 PRINTS PR00417 Prokaryotic DNA topoisomerase I signature 161 179 9.2E-35 T 13-10-2018 IPR013497 DNA topoisomerase, type IA, central GO:0003677|GO:0003916|GO:0006265 TOPB45_1062 ae46cd2b8831cd7739dcc00eb7d5009d 541 PRINTS PR00417 Prokaryotic DNA topoisomerase I signature 283 292 9.2E-35 T 13-10-2018 IPR013497 DNA topoisomerase, type IA, central GO:0003677|GO:0003916|GO:0006265 TOPB45_1062 ae46cd2b8831cd7739dcc00eb7d5009d 541 SMART SM00437 241 493 5.8E-85 T 13-10-2018 IPR003602 DNA topoisomerase, type IA, DNA-binding domain GO:0003677|GO:0003916|GO:0006265 TOPB45_1062 ae46cd2b8831cd7739dcc00eb7d5009d 541 Pfam PF01751 Toprim domain 3 111 3.2E-24 T 13-10-2018 IPR006171 TOPRIM domain TOPB45_1062 ae46cd2b8831cd7739dcc00eb7d5009d 541 SMART SM00493 1 100 3.2E-30 T 13-10-2018 IPR006171 TOPRIM domain TOPB45_1062 ae46cd2b8831cd7739dcc00eb7d5009d 541 TIGRFAM TIGR01051 topA_bact: DNA topoisomerase I 3 534 8.5E-153 T 13-10-2018 IPR005733 DNA topoisomerase I, bacterial-type GO:0003677|GO:0003917|GO:0006265 TOPB45_1062 ae46cd2b8831cd7739dcc00eb7d5009d 541 Gene3D G3DSA:2.70.20.10 183 439 1.8E-118 T 13-10-2018 IPR013825 DNA topoisomerase, type IA, central region, subdomain 2 TOPB45_1062 ae46cd2b8831cd7739dcc00eb7d5009d 541 SUPERFAMILY SSF56712 1 540 2.35E-151 T 13-10-2018 IPR023405 DNA topoisomerase, type IA, core domain TOPB45_1062 ae46cd2b8831cd7739dcc00eb7d5009d 541 Gene3D G3DSA:3.40.50.140 1 131 4.8E-38 T 13-10-2018 TOPB45_0559 642a6942eb722ffcafaf88ceebe505e8 459 PIRSF PIRSF004919 4 457 1.1E-130 T 13-10-2018 IPR025502 TldD TOPB45_0559 642a6942eb722ffcafaf88ceebe505e8 459 Pfam PF01523 Putative modulator of DNA gyrase 25 311 5.7E-55 T 13-10-2018 IPR002510 Metalloprotease TldD/PmbA GO:0006508|GO:0008237 TOPB45_0559 642a6942eb722ffcafaf88ceebe505e8 459 Gene3D G3DSA:3.30.2290.10 3 211 2.9E-8 T 13-10-2018 IPR035068 Metalloprotease TldD/PmbA, N-terminal TOPB45_0559 642a6942eb722ffcafaf88ceebe505e8 459 SUPERFAMILY SSF111283 10 455 6.67E-101 T 13-10-2018 IPR036059 Metalloprotease TldD/PmbA superfamily GO:0006508|GO:0008237 TOPB45_0035 b2cc8d671ecda44763593edef2606200 255 Pfam PF02405 Permease MlaE 43 252 1.5E-77 T 13-10-2018 IPR030802 ABC transporter permease MalE GO:0043190 TOPB45_0035 b2cc8d671ecda44763593edef2606200 255 TIGRFAM TIGR00056 TIGR00056: ABC transport permease subunit 21 255 4.9E-76 T 13-10-2018 IPR003453 ABC transport permease subunit MlaE, Proteobacteria TOPB45_1625 cda2f3d9590c948f636fd674a55dc422 151 Pfam PF02082 Transcriptional regulator 3 81 2.8E-25 T 13-10-2018 IPR000944 Transcription regulator Rrf2-type TOPB45_1625 cda2f3d9590c948f636fd674a55dc422 151 SUPERFAMILY SSF46785 3 132 1.76E-31 T 13-10-2018 IPR036390 Winged helix DNA-binding domain superfamily TOPB45_1625 cda2f3d9590c948f636fd674a55dc422 151 Gene3D G3DSA:1.10.10.10 1 144 1.5E-42 T 13-10-2018 IPR036388 Winged helix-like DNA-binding domain superfamily TOPB45_1625 cda2f3d9590c948f636fd674a55dc422 151 TIGRFAM TIGR00738 rrf2_super: Rrf2 family protein 3 132 9.1E-36 T 13-10-2018 IPR000944 Transcription regulator Rrf2-type TOPB45_1625 cda2f3d9590c948f636fd674a55dc422 151 ProSitePatterns PS01332 Rrf2-type HTH domain signature. 49 67 - T 13-10-2018 IPR030489 Transcription regulator Rrf2-type, conserved site TOPB45_0431 f5326637f5c16a4090d5244061056571 333 PIRSF PIRSF002401 1 333 1.0E-143 T 13-10-2018 IPR035101 GTP-binding protein, Obg-type TOPB45_0431 f5326637f5c16a4090d5244061056571 333 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 212 227 2.5E-36 T 13-10-2018 IPR006073 GTP binding domain GO:0005525 TOPB45_0431 f5326637f5c16a4090d5244061056571 333 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 229 247 2.5E-36 T 13-10-2018 IPR006073 GTP binding domain GO:0005525 TOPB45_0431 f5326637f5c16a4090d5244061056571 333 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 184 202 2.5E-36 T 13-10-2018 IPR006073 GTP binding domain GO:0005525 TOPB45_0431 f5326637f5c16a4090d5244061056571 333 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 163 183 2.5E-36 T 13-10-2018 IPR006073 GTP binding domain GO:0005525 TOPB45_0431 f5326637f5c16a4090d5244061056571 333 Gene3D G3DSA:2.70.210.12 1 159 8.7E-66 T 13-10-2018 IPR036726 GTP1/OBG domain superfamily TOPB45_0431 f5326637f5c16a4090d5244061056571 333 Pfam PF01018 GTP1/OBG 5 159 2.7E-65 T 13-10-2018 IPR006169 GTP1/OBG domain TOPB45_0431 f5326637f5c16a4090d5244061056571 333 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 162 324 1.9E-15 T 13-10-2018 IPR005225 Small GTP-binding protein domain GO:0005525 TOPB45_0431 f5326637f5c16a4090d5244061056571 333 Gene3D G3DSA:3.40.50.300 160 333 6.0E-56 T 13-10-2018 TOPB45_0431 f5326637f5c16a4090d5244061056571 333 SUPERFAMILY SSF52540 151 331 1.57E-51 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0431 f5326637f5c16a4090d5244061056571 333 Pfam PF01926 50S ribosome-binding GTPase 162 283 5.1E-26 T 13-10-2018 IPR006073 GTP binding domain GO:0005525 TOPB45_0431 f5326637f5c16a4090d5244061056571 333 Hamap MF_01454 GTPase Obg [obg]. 3 331 49.681 T 13-10-2018 IPR014100 GTP-binding protein Obg/CgtA GO:0000287|GO:0003924|GO:0005525 TOPB45_0431 f5326637f5c16a4090d5244061056571 333 SUPERFAMILY SSF82051 3 159 1.05E-59 T 13-10-2018 IPR036726 GTP1/OBG domain superfamily TOPB45_0431 f5326637f5c16a4090d5244061056571 333 ProSitePatterns PS00905 GTP1/OBG family signature. 214 227 - T 13-10-2018 IPR006074 GTP1/OBG, conserved site GO:0005525 TOPB45_0431 f5326637f5c16a4090d5244061056571 333 TIGRFAM TIGR02729 Obg_CgtA: Obg family GTPase CgtA 4 330 4.1E-146 T 13-10-2018 IPR014100 GTP-binding protein Obg/CgtA GO:0000287|GO:0003924|GO:0005525 TOPB45_0413 f03d1009d3ff701ca319d18f6db93094 196 Pfam PF00691 OmpA family 93 187 7.3E-18 T 13-10-2018 IPR006665 OmpA-like domain TOPB45_0413 f03d1009d3ff701ca319d18f6db93094 196 PRINTS PR01021 OMPA domain signature 124 139 2.7E-11 T 13-10-2018 IPR006664 Outer membrane protein, bacterial GO:0009279|GO:0016021 TOPB45_0413 f03d1009d3ff701ca319d18f6db93094 196 PRINTS PR01021 OMPA domain signature 139 155 2.7E-11 T 13-10-2018 IPR006664 Outer membrane protein, bacterial GO:0009279|GO:0016021 TOPB45_0413 f03d1009d3ff701ca319d18f6db93094 196 PRINTS PR01021 OMPA domain signature 94 116 2.7E-11 T 13-10-2018 IPR006664 Outer membrane protein, bacterial GO:0009279|GO:0016021 TOPB45_0413 f03d1009d3ff701ca319d18f6db93094 196 Hamap MF_02204 Peptidoglycan-associated lipoprotein [pal]. 1 194 26.52 T 13-10-2018 IPR039001 Peptidoglycan-associated lipoprotein GO:0009279|GO:0051301 TOPB45_0413 f03d1009d3ff701ca319d18f6db93094 196 SUPERFAMILY SSF103088 91 194 4.05E-32 T 13-10-2018 IPR036737 OmpA-like domain superfamily TOPB45_0413 f03d1009d3ff701ca319d18f6db93094 196 Gene3D G3DSA:3.30.1330.60 67 194 9.5E-35 T 13-10-2018 IPR036737 OmpA-like domain superfamily TOPB45_0413 f03d1009d3ff701ca319d18f6db93094 196 TIGRFAM TIGR02802 Pal_lipo: peptidoglycan-associated lipoprotein 92 193 2.4E-39 T 13-10-2018 IPR014169 Peptidoglycan-associated lipoprotein, C-terminal GO:0009279 TOPB45_0975 85e622917d349ed73f9193962b2ba3ce 353 Pfam PF05189 RNA 3'-terminal phosphate cyclase (RTC), insert domain 188 278 3.2E-4 T 13-10-2018 IPR013791 RNA 3'-terminal phosphate cyclase, insert domain TOPB45_0975 85e622917d349ed73f9193962b2ba3ce 353 SUPERFAMILY SSF55205 1 217 5.75E-54 T 13-10-2018 IPR013792 RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta GO:0003824 TOPB45_0975 85e622917d349ed73f9193962b2ba3ce 353 Gene3D G3DSA:3.65.10.20 4 331 6.4E-102 T 13-10-2018 IPR037136 RNA 3'-terminal phosphate cyclase domain superfamily TOPB45_0975 85e622917d349ed73f9193962b2ba3ce 353 Hamap MF_00200 RNA 3'-terminal phosphate cyclase [rtcA]. 1 349 36.324 T 13-10-2018 IPR017770 RNA 3'-terminal phosphate cyclase type 1 GO:0003963|GO:0006396 TOPB45_0975 85e622917d349ed73f9193962b2ba3ce 353 SUPERFAMILY SSF52913 196 282 4.84E-10 T 13-10-2018 IPR036553 RNA 3'-terminal phosphate cyclase, insert domain superfamily TOPB45_0975 85e622917d349ed73f9193962b2ba3ce 353 PIRSF PIRSF005378 1 352 3.9E-91 T 13-10-2018 IPR000228 RNA 3'-terminal phosphate cyclase GO:0006396 TOPB45_0975 85e622917d349ed73f9193962b2ba3ce 353 Gene3D G3DSA:3.30.360.20 182 279 6.4E-102 T 13-10-2018 IPR036553 RNA 3'-terminal phosphate cyclase, insert domain superfamily TOPB45_0975 85e622917d349ed73f9193962b2ba3ce 353 Pfam PF01137 RNA 3'-terminal phosphate cyclase 8 331 1.0E-67 T 13-10-2018 IPR023797 RNA 3'-terminal phosphate cyclase domain TOPB45_0975 85e622917d349ed73f9193962b2ba3ce 353 TIGRFAM TIGR03399 RNA_3prim_cycl: RNA 3'-phosphate cyclase 2 331 2.4E-95 T 13-10-2018 IPR017770 RNA 3'-terminal phosphate cyclase type 1 GO:0003963|GO:0006396 TOPB45_0029 3330671c29dccef6724843e9fbc59eac 274 Pfam PF06230 Protein of unknown function (DUF1009) 61 267 1.5E-74 T 13-10-2018 IPR010415 Protein of unknown function DUF1009 KEGG: 00540+3.6.1.54 TOPB45_0029 3330671c29dccef6724843e9fbc59eac 274 Gene3D G3DSA:3.40.140.80 134 274 9.6E-51 T 13-10-2018 TOPB45_0029 3330671c29dccef6724843e9fbc59eac 274 Gene3D G3DSA:3.40.50.20 4 133 1.7E-31 T 13-10-2018 TOPB45_0105 ccae70f97759b1457cd574a178903935 386 Pfam PF00162 Phosphoglycerate kinase 5 376 4.1E-150 T 13-10-2018 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_0105 ccae70f97759b1457cd574a178903935 386 ProSitePatterns PS00111 Phosphoglycerate kinase signature. 13 23 - T 13-10-2018 IPR015911 Phosphoglycerate kinase, conserved site GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_0105 ccae70f97759b1457cd574a178903935 386 PIRSF PIRSF000724 1 386 2.2E-143 T 13-10-2018 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_0105 ccae70f97759b1457cd574a178903935 386 PRINTS PR00477 Phosphoglycerate kinase family signature 29 51 1.1E-82 T 13-10-2018 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_0105 ccae70f97759b1457cd574a178903935 386 PRINTS PR00477 Phosphoglycerate kinase family signature 362 379 1.1E-82 T 13-10-2018 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_0105 ccae70f97759b1457cd574a178903935 386 PRINTS PR00477 Phosphoglycerate kinase family signature 188 207 1.1E-82 T 13-10-2018 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_0105 ccae70f97759b1457cd574a178903935 386 PRINTS PR00477 Phosphoglycerate kinase family signature 8 24 1.1E-82 T 13-10-2018 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_0105 ccae70f97759b1457cd574a178903935 386 PRINTS PR00477 Phosphoglycerate kinase family signature 165 187 1.1E-82 T 13-10-2018 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_0105 ccae70f97759b1457cd574a178903935 386 PRINTS PR00477 Phosphoglycerate kinase family signature 106 121 1.1E-82 T 13-10-2018 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_0105 ccae70f97759b1457cd574a178903935 386 PRINTS PR00477 Phosphoglycerate kinase family signature 134 156 1.1E-82 T 13-10-2018 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_0105 ccae70f97759b1457cd574a178903935 386 PRINTS PR00477 Phosphoglycerate kinase family signature 306 331 1.1E-82 T 13-10-2018 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_0105 ccae70f97759b1457cd574a178903935 386 PRINTS PR00477 Phosphoglycerate kinase family signature 339 350 1.1E-82 T 13-10-2018 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_0105 ccae70f97759b1457cd574a178903935 386 Gene3D G3DSA:3.40.50.1260 167 376 6.2E-155 T 13-10-2018 IPR015824 Phosphoglycerate kinase, N-terminal GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_0105 ccae70f97759b1457cd574a178903935 386 Gene3D G3DSA:3.40.50.1260 6 384 6.2E-155 T 13-10-2018 IPR015824 Phosphoglycerate kinase, N-terminal GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_0105 ccae70f97759b1457cd574a178903935 386 SUPERFAMILY SSF53748 1 385 3.18E-146 T 13-10-2018 IPR036043 Phosphoglycerate kinase superfamily GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_0105 ccae70f97759b1457cd574a178903935 386 Hamap MF_00145 Phosphoglycerate kinase [pgk]. 3 386 38.573 T 13-10-2018 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_0452 3a8025c657c21c3e6c3f9a31b7ff91c6 286 Gene3D G3DSA:3.10.310.10 17 277 1.9E-77 T 13-10-2018 TOPB45_0452 3a8025c657c21c3e6c3f9a31b7ff91c6 286 SUPERFAMILY SSF54506 17 137 1.51E-31 T 13-10-2018 TOPB45_0452 3a8025c657c21c3e6c3f9a31b7ff91c6 286 SUPERFAMILY SSF54506 138 280 1.35E-36 T 13-10-2018 TOPB45_0452 3a8025c657c21c3e6c3f9a31b7ff91c6 286 Pfam PF01678 Diaminopimelate epimerase 17 132 3.4E-21 T 13-10-2018 IPR001653 Diaminopimelate epimerase, DapF GO:0008837|GO:0009089 KEGG: 00300+5.1.1.7|MetaCyc: PWY-2941|MetaCyc: PWY-5097 TOPB45_0452 3a8025c657c21c3e6c3f9a31b7ff91c6 286 Pfam PF01678 Diaminopimelate epimerase 155 274 3.4E-16 T 13-10-2018 IPR001653 Diaminopimelate epimerase, DapF GO:0008837|GO:0009089 KEGG: 00300+5.1.1.7|MetaCyc: PWY-2941|MetaCyc: PWY-5097 TOPB45_0452 3a8025c657c21c3e6c3f9a31b7ff91c6 286 Hamap MF_00197 Diaminopimelate epimerase [dapF]. 15 282 31.099 T 13-10-2018 IPR001653 Diaminopimelate epimerase, DapF GO:0008837|GO:0009089 KEGG: 00300+5.1.1.7|MetaCyc: PWY-2941|MetaCyc: PWY-5097 TOPB45_0452 3a8025c657c21c3e6c3f9a31b7ff91c6 286 ProSitePatterns PS01326 Diaminopimelate epimerase signature. 80 94 - T 13-10-2018 IPR018510 Diaminopimelate epimerase, active site GO:0005737|GO:0008837|GO:0009089 KEGG: 00300+5.1.1.7|MetaCyc: PWY-2941|MetaCyc: PWY-5097 TOPB45_0452 3a8025c657c21c3e6c3f9a31b7ff91c6 286 Gene3D G3DSA:3.10.310.10 129 269 1.9E-77 T 13-10-2018 TOPB45_0452 3a8025c657c21c3e6c3f9a31b7ff91c6 286 TIGRFAM TIGR00652 DapF: diaminopimelate epimerase 16 281 9.6E-74 T 13-10-2018 IPR001653 Diaminopimelate epimerase, DapF GO:0008837|GO:0009089 KEGG: 00300+5.1.1.7|MetaCyc: PWY-2941|MetaCyc: PWY-5097 TOPB45_0830 d621e9f8ddec436a079c1db82f4d63f5 308 Pfam PF04055 Radical SAM superfamily 80 246 3.4E-9 T 13-10-2018 IPR007197 Radical SAM GO:0003824|GO:0051536 TOPB45_0830 d621e9f8ddec436a079c1db82f4d63f5 308 PIRSF PIRSF004869 4 305 9.8E-87 T 13-10-2018 IPR016431 Pyruvate-formate lyase-activating enzyme, predicted TOPB45_0830 d621e9f8ddec436a079c1db82f4d63f5 308 Gene3D G3DSA:3.20.20.70 72 299 1.3E-13 T 13-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 TOPB45_0830 d621e9f8ddec436a079c1db82f4d63f5 308 SUPERFAMILY SSF102114 82 294 8.63E-12 T 13-10-2018 TOPB45_0589 03aba6b002cfc1cb906d6afeeb3b5322 84 Hamap MF_00386 Putative membrane protein insertion efficiency factor [yidD]. 2 74 22.765 T 13-10-2018 IPR002696 Putative membrane protein insertion efficiency factor TOPB45_0589 03aba6b002cfc1cb906d6afeeb3b5322 84 SMART SM01234 2 73 2.9E-35 T 13-10-2018 IPR002696 Putative membrane protein insertion efficiency factor TOPB45_0589 03aba6b002cfc1cb906d6afeeb3b5322 84 ProDom PD004225 UPF0161 ALPHA-HEMOLYSIN YIDD UNCHARACTERIZED CYTOSOLIC PRECURSOR SIGNAL YTJA RNPA SIMILAR 17 73 5.0E-17 T 13-10-2018 IPR002696 Putative membrane protein insertion efficiency factor TOPB45_0589 03aba6b002cfc1cb906d6afeeb3b5322 84 TIGRFAM TIGR00278 TIGR00278: putative membrane protein insertion efficiency factor 7 82 1.0E-22 T 13-10-2018 IPR002696 Putative membrane protein insertion efficiency factor TOPB45_0589 03aba6b002cfc1cb906d6afeeb3b5322 84 Pfam PF01809 Haemolytic domain 3 72 4.1E-28 T 13-10-2018 IPR002696 Putative membrane protein insertion efficiency factor TOPB45_1482 eaaab10db242a738c693d702bd434fcd 810 Pfam PF00122 E1-E2 ATPase 99 278 2.5E-49 T 13-10-2018 TOPB45_1482 eaaab10db242a738c693d702bd434fcd 810 SUPERFAMILY SSF56784 296 656 4.06E-40 T 13-10-2018 IPR036412 HAD-like superfamily TOPB45_1482 eaaab10db242a738c693d702bd434fcd 810 Gene3D G3DSA:1.20.1110.10 26 294 3.5E-61 T 13-10-2018 TOPB45_1482 eaaab10db242a738c693d702bd434fcd 810 Pfam PF00689 Cation transporting ATPase, C-terminus 640 802 4.8E-12 T 13-10-2018 IPR006068 Cation-transporting P-type ATPase, C-terminal Reactome: R-HSA-936837 TOPB45_1482 eaaab10db242a738c693d702bd434fcd 810 Gene3D G3DSA:1.20.1110.10 602 801 8.0E-66 T 13-10-2018 TOPB45_1482 eaaab10db242a738c693d702bd434fcd 810 ProSitePatterns PS00154 E1-E2 ATPases phosphorylation site. 300 306 - T 13-10-2018 IPR018303 P-type ATPase, phosphorylation site Reactome: R-HSA-936837 TOPB45_1482 eaaab10db242a738c693d702bd434fcd 810 TIGRFAM TIGR01494 ATPase_P-type: HAD ATPase, P-type, family IC 503 645 5.9E-27 T 13-10-2018 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 TOPB45_1482 eaaab10db242a738c693d702bd434fcd 810 TIGRFAM TIGR01494 ATPase_P-type: HAD ATPase, P-type, family IC 71 508 1.1E-53 T 13-10-2018 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 TOPB45_1482 eaaab10db242a738c693d702bd434fcd 810 SMART SM00831 1 64 2.8E-5 T 13-10-2018 IPR004014 Cation-transporting P-type ATPase, N-terminal Reactome: R-HSA-936837 TOPB45_1482 eaaab10db242a738c693d702bd434fcd 810 Gene3D G3DSA:2.70.150.10 7 200 3.5E-61 T 13-10-2018 TOPB45_1482 eaaab10db242a738c693d702bd434fcd 810 Gene3D G3DSA:3.40.50.1000 466 601 8.0E-66 T 13-10-2018 IPR023214 HAD superfamily TOPB45_1482 eaaab10db242a738c693d702bd434fcd 810 Pfam PF00690 Cation transporter/ATPase, N-terminus 7 59 6.0E-11 T 13-10-2018 IPR004014 Cation-transporting P-type ATPase, N-terminal Reactome: R-HSA-936837 TOPB45_1482 eaaab10db242a738c693d702bd434fcd 810 Pfam PF00702 haloacid dehalogenase-like hydrolase 294 571 3.9E-18 T 13-10-2018 TOPB45_1482 eaaab10db242a738c693d702bd434fcd 810 PRINTS PR01836 Magnesium-transporting ATPase signature 665 678 1.6E-40 T 13-10-2018 IPR006415 P-type ATPase, subfamily IIIB GO:0015444|GO:0015693|GO:0016021 TOPB45_1482 eaaab10db242a738c693d702bd434fcd 810 PRINTS PR01836 Magnesium-transporting ATPase signature 615 630 1.6E-40 T 13-10-2018 IPR006415 P-type ATPase, subfamily IIIB GO:0015444|GO:0015693|GO:0016021 TOPB45_1482 eaaab10db242a738c693d702bd434fcd 810 PRINTS PR01836 Magnesium-transporting ATPase signature 633 644 1.6E-40 T 13-10-2018 IPR006415 P-type ATPase, subfamily IIIB GO:0015444|GO:0015693|GO:0016021 TOPB45_1482 eaaab10db242a738c693d702bd434fcd 810 PRINTS PR01836 Magnesium-transporting ATPase signature 716 737 1.6E-40 T 13-10-2018 IPR006415 P-type ATPase, subfamily IIIB GO:0015444|GO:0015693|GO:0016021 TOPB45_1482 eaaab10db242a738c693d702bd434fcd 810 PRINTS PR01836 Magnesium-transporting ATPase signature 765 786 1.6E-40 T 13-10-2018 IPR006415 P-type ATPase, subfamily IIIB GO:0015444|GO:0015693|GO:0016021 TOPB45_1482 eaaab10db242a738c693d702bd434fcd 810 PRINTS PR01836 Magnesium-transporting ATPase signature 228 247 1.6E-40 T 13-10-2018 IPR006415 P-type ATPase, subfamily IIIB GO:0015444|GO:0015693|GO:0016021 TOPB45_1482 eaaab10db242a738c693d702bd434fcd 810 PRINTS PR01836 Magnesium-transporting ATPase signature 332 345 1.6E-40 T 13-10-2018 IPR006415 P-type ATPase, subfamily IIIB GO:0015444|GO:0015693|GO:0016021 TOPB45_1482 eaaab10db242a738c693d702bd434fcd 810 PRINTS PR01836 Magnesium-transporting ATPase signature 685 701 1.6E-40 T 13-10-2018 IPR006415 P-type ATPase, subfamily IIIB GO:0015444|GO:0015693|GO:0016021 TOPB45_1482 eaaab10db242a738c693d702bd434fcd 810 PRINTS PR01836 Magnesium-transporting ATPase signature 211 227 1.6E-40 T 13-10-2018 IPR006415 P-type ATPase, subfamily IIIB GO:0015444|GO:0015693|GO:0016021 TOPB45_1482 eaaab10db242a738c693d702bd434fcd 810 Gene3D G3DSA:3.40.1110.10 347 465 8.0E-66 T 13-10-2018 IPR023299 P-type ATPase, cytoplasmic domain N GO:0000166 Reactome: R-HSA-936837 TOPB45_1482 eaaab10db242a738c693d702bd434fcd 810 SUPERFAMILY SSF81653 102 197 3.4E-31 T 13-10-2018 IPR008250 P-type ATPase, A domain superfamily Reactome: R-HSA-936837 TOPB45_1482 eaaab10db242a738c693d702bd434fcd 810 Gene3D G3DSA:3.40.50.1000 295 307 3.5E-61 T 13-10-2018 IPR023214 HAD superfamily TOPB45_1482 eaaab10db242a738c693d702bd434fcd 810 TIGRFAM TIGR01524 ATPase-IIIB_Mg: magnesium-translocating P-type ATPase 7 808 4.9E-211 T 13-10-2018 IPR006415 P-type ATPase, subfamily IIIB GO:0015444|GO:0015693|GO:0016021 TOPB45_1482 eaaab10db242a738c693d702bd434fcd 810 SUPERFAMILY SSF81665 5 807 5.23E-87 T 13-10-2018 IPR023298 P-type ATPase, transmembrane domain superfamily Reactome: R-HSA-936837 TOPB45_0193 16fedde665c6ed31ed1142a1015843da 402 SUPERFAMILY SSF54106 39 83 1.7E-12 T 13-10-2018 TOPB45_0193 16fedde665c6ed31ed1142a1015843da 402 Pfam PF00877 NlpC/P60 family 276 379 5.1E-24 T 13-10-2018 IPR000064 Endopeptidase, NLPC/P60 domain TOPB45_0193 16fedde665c6ed31ed1142a1015843da 402 Gene3D G3DSA:3.90.1720.10 260 383 1.4E-36 T 13-10-2018 TOPB45_0193 16fedde665c6ed31ed1142a1015843da 402 SUPERFAMILY SSF54001 260 383 2.06E-33 T 13-10-2018 IPR038765 Papain-like cysteine peptidase superfamily TOPB45_0193 16fedde665c6ed31ed1142a1015843da 402 Gene3D G3DSA:3.10.350.10 39 84 6.4E-18 T 13-10-2018 IPR036779 LysM domain superfamily TOPB45_0193 16fedde665c6ed31ed1142a1015843da 402 SMART SM00257 170 213 1.4E-15 T 13-10-2018 IPR018392 LysM domain TOPB45_0193 16fedde665c6ed31ed1142a1015843da 402 SMART SM00257 40 83 1.6E-14 T 13-10-2018 IPR018392 LysM domain TOPB45_0193 16fedde665c6ed31ed1142a1015843da 402 SMART SM00257 110 153 8.2E-15 T 13-10-2018 IPR018392 LysM domain TOPB45_0193 16fedde665c6ed31ed1142a1015843da 402 SUPERFAMILY SSF54106 169 214 4.32E-12 T 13-10-2018 TOPB45_0193 16fedde665c6ed31ed1142a1015843da 402 Gene3D G3DSA:3.10.350.10 159 218 2.0E-17 T 13-10-2018 IPR036779 LysM domain superfamily TOPB45_0193 16fedde665c6ed31ed1142a1015843da 402 Gene3D G3DSA:3.10.350.10 95 158 6.2E-16 T 13-10-2018 IPR036779 LysM domain superfamily TOPB45_0193 16fedde665c6ed31ed1142a1015843da 402 SUPERFAMILY SSF54106 110 153 5.89E-11 T 13-10-2018 TOPB45_0193 16fedde665c6ed31ed1142a1015843da 402 Pfam PF01476 LysM domain 111 152 7.9E-14 T 13-10-2018 IPR018392 LysM domain TOPB45_0193 16fedde665c6ed31ed1142a1015843da 402 Pfam PF01476 LysM domain 41 83 1.0E-14 T 13-10-2018 IPR018392 LysM domain TOPB45_0193 16fedde665c6ed31ed1142a1015843da 402 Pfam PF01476 LysM domain 171 213 3.2E-15 T 13-10-2018 IPR018392 LysM domain TOPB45_0794 e10b4ab3add7d25f1065ea204bf81991 69 Hamap MF_00358 30S ribosomal protein S21 [rpsU]. 1 57 21.908 T 13-10-2018 IPR001911 Ribosomal protein S21 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0794 e10b4ab3add7d25f1065ea204bf81991 69 ProDom PD005521 RIBOSOMAL S21 RIBONUCLEOPROTEIN 30S S21P A SSU SUBUNIT SEQUENCING DIRECT 16 53 3.0E-7 T 13-10-2018 IPR001911 Ribosomal protein S21 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0794 e10b4ab3add7d25f1065ea204bf81991 69 TIGRFAM TIGR00030 S21p: ribosomal protein bS21 4 59 3.0E-21 T 13-10-2018 IPR001911 Ribosomal protein S21 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0794 e10b4ab3add7d25f1065ea204bf81991 69 ProSitePatterns PS01181 Ribosomal protein S21 signature. 13 25 - T 13-10-2018 IPR018278 Ribosomal protein S21, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0794 e10b4ab3add7d25f1065ea204bf81991 69 PRINTS PR00976 Ribosomal protein S21 family signature 5 13 1.2E-11 T 13-10-2018 IPR001911 Ribosomal protein S21 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0794 e10b4ab3add7d25f1065ea204bf81991 69 PRINTS PR00976 Ribosomal protein S21 family signature 13 22 1.2E-11 T 13-10-2018 IPR001911 Ribosomal protein S21 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0794 e10b4ab3add7d25f1065ea204bf81991 69 PRINTS PR00976 Ribosomal protein S21 family signature 25 35 1.2E-11 T 13-10-2018 IPR001911 Ribosomal protein S21 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0794 e10b4ab3add7d25f1065ea204bf81991 69 PRINTS PR00976 Ribosomal protein S21 family signature 37 47 1.2E-11 T 13-10-2018 IPR001911 Ribosomal protein S21 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0794 e10b4ab3add7d25f1065ea204bf81991 69 Pfam PF01165 Ribosomal protein S21 4 56 2.5E-20 T 13-10-2018 IPR001911 Ribosomal protein S21 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0794 e10b4ab3add7d25f1065ea204bf81991 69 Gene3D G3DSA:1.20.5.1150 16 54 1.2E-13 T 13-10-2018 IPR038380 Ribosomal protein S21 superfamily Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0203 c58cd20d942b290a265a7b6a43e68270 419 Gene3D G3DSA:3.80.30.20 125 355 8.5E-79 T 13-10-2018 IPR023404 Radical SAM, alpha/beta horseshoe TOPB45_0203 c58cd20d942b290a265a7b6a43e68270 419 Hamap MF_01865 Ribosomal protein S12 methylthiotransferase RimO [rimO]. 2 418 56.013 T 13-10-2018 IPR005840 Ribosomal protein S12 methylthiotransferase RimO GO:0005737|GO:0016740|GO:0018339|GO:0051539 TOPB45_0203 c58cd20d942b290a265a7b6a43e68270 419 Gene3D G3DSA:3.40.50.12160 2 124 1.4E-32 T 13-10-2018 IPR038135 Methylthiotransferase, N-terminal domain superfamily TOPB45_0203 c58cd20d942b290a265a7b6a43e68270 419 Pfam PF01938 TRAM domain 354 418 2.2E-5 T 13-10-2018 IPR002792 TRAM domain TOPB45_0203 c58cd20d942b290a265a7b6a43e68270 419 TIGRFAM TIGR01125 TIGR01125: ribosomal protein S12 methylthiotransferase RimO 5 416 1.5E-128 T 13-10-2018 IPR005840 Ribosomal protein S12 methylthiotransferase RimO GO:0005737|GO:0016740|GO:0018339|GO:0051539 TOPB45_0203 c58cd20d942b290a265a7b6a43e68270 419 Pfam PF04055 Radical SAM superfamily 129 299 5.8E-24 T 13-10-2018 IPR007197 Radical SAM GO:0003824|GO:0051536 TOPB45_0203 c58cd20d942b290a265a7b6a43e68270 419 SMART SM00729 123 341 5.1E-49 T 13-10-2018 IPR006638 Elp3/MiaB/NifB GO:0003824|GO:0051536 TOPB45_0203 c58cd20d942b290a265a7b6a43e68270 419 Pfam PF00919 Uncharacterized protein family UPF0004 3 101 1.1E-22 T 13-10-2018 IPR013848 Methylthiotransferase, N-terminal GO:0051539 TOPB45_0203 c58cd20d942b290a265a7b6a43e68270 419 Gene3D G3DSA:2.40.50.140 356 419 2.0E-11 T 13-10-2018 TOPB45_0203 c58cd20d942b290a265a7b6a43e68270 419 SUPERFAMILY SSF102114 103 351 4.32E-56 T 13-10-2018 TOPB45_0203 c58cd20d942b290a265a7b6a43e68270 419 ProSitePatterns PS01278 Methylthiotransferase radical SAM domain signature. 127 147 - T 13-10-2018 IPR020612 Methylthiotransferase, conserved site GO:0051539 TOPB45_0203 c58cd20d942b290a265a7b6a43e68270 419 TIGRFAM TIGR00089 TIGR00089: radical SAM methylthiotransferase, MiaB/RimO family 3 416 1.9E-108 T 13-10-2018 IPR005839 Methylthiotransferase GO:0006400|GO:0016740|GO:0051539 TOPB45_1137 50e27f61bbb0382bac5a578196008214 599 Gene3D G3DSA:3.30.70.870 290 371 2.6E-36 T 13-10-2018 TOPB45_1137 50e27f61bbb0382bac5a578196008214 599 Hamap MF_00071 Elongation factor 4 [lepA]. 1 599 293.041 T 13-10-2018 IPR006297 Elongation factor 4 GO:0005525 TOPB45_1137 50e27f61bbb0382bac5a578196008214 599 SUPERFAMILY SSF54980 403 498 2.21E-23 T 13-10-2018 IPR035647 EF-G domain III/V-like TOPB45_1137 50e27f61bbb0382bac5a578196008214 599 SUPERFAMILY SSF52540 5 210 4.03E-58 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1137 50e27f61bbb0382bac5a578196008214 599 TIGRFAM TIGR01393 lepA: elongation factor 4 8 599 2.0E-300 T 13-10-2018 IPR006297 Elongation factor 4 GO:0005525 TOPB45_1137 50e27f61bbb0382bac5a578196008214 599 Gene3D G3DSA:3.40.50.300 6 190 1.5E-75 T 13-10-2018 TOPB45_1137 50e27f61bbb0382bac5a578196008214 599 PRINTS PR00315 GTP-binding elongation factor signature 95 106 2.2E-14 T 13-10-2018 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TOPB45_1137 50e27f61bbb0382bac5a578196008214 599 PRINTS PR00315 GTP-binding elongation factor signature 131 140 2.2E-14 T 13-10-2018 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TOPB45_1137 50e27f61bbb0382bac5a578196008214 599 PRINTS PR00315 GTP-binding elongation factor signature 11 24 2.2E-14 T 13-10-2018 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TOPB45_1137 50e27f61bbb0382bac5a578196008214 599 PRINTS PR00315 GTP-binding elongation factor signature 79 89 2.2E-14 T 13-10-2018 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TOPB45_1137 50e27f61bbb0382bac5a578196008214 599 PRINTS PR00315 GTP-binding elongation factor signature 54 62 2.2E-14 T 13-10-2018 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TOPB45_1137 50e27f61bbb0382bac5a578196008214 599 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 10 179 4.6E-20 T 13-10-2018 IPR005225 Small GTP-binding protein domain GO:0005525 TOPB45_1137 50e27f61bbb0382bac5a578196008214 599 SUPERFAMILY SSF50447 188 285 1.15E-21 T 13-10-2018 IPR009000 Translation protein, beta-barrel domain superfamily TOPB45_1137 50e27f61bbb0382bac5a578196008214 599 Pfam PF00679 Elongation factor G C-terminus 403 490 5.8E-21 T 13-10-2018 IPR000640 Elongation factor EFG, domain V-like TOPB45_1137 50e27f61bbb0382bac5a578196008214 599 Gene3D G3DSA:3.30.70.2570 484 558 8.1E-36 T 13-10-2018 IPR038363 LepA, C-terminal domain superfamily TOPB45_1137 50e27f61bbb0382bac5a578196008214 599 SUPERFAMILY SSF54980 296 374 7.19E-19 T 13-10-2018 IPR035647 EF-G domain III/V-like TOPB45_1137 50e27f61bbb0382bac5a578196008214 599 Pfam PF03144 Elongation factor Tu domain 2 210 280 2.1E-9 T 13-10-2018 IPR004161 Translation elongation factor EFTu-like, domain 2 GO:0005525 TOPB45_1137 50e27f61bbb0382bac5a578196008214 599 Gene3D G3DSA:3.30.70.3380 372 483 2.3E-42 T 13-10-2018 TOPB45_1137 50e27f61bbb0382bac5a578196008214 599 Pfam PF06421 GTP-binding protein LepA C-terminus 492 598 2.5E-51 T 13-10-2018 IPR013842 GTP-binding protein LepA, C-terminal TOPB45_1137 50e27f61bbb0382bac5a578196008214 599 ProSitePatterns PS00301 Translational (tr)-type guanine nucleotide-binding (G) domain signature. 47 62 - T 13-10-2018 IPR031157 Tr-type G domain, conserved site TOPB45_1137 50e27f61bbb0382bac5a578196008214 599 Gene3D G3DSA:2.40.30.10 191 289 5.4E-36 T 13-10-2018 TOPB45_1137 50e27f61bbb0382bac5a578196008214 599 Pfam PF00009 Elongation factor Tu GTP binding domain 8 187 1.0E-55 T 13-10-2018 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TOPB45_1630 db636b649f2beacaae7c12825b5dbc88 434 Pfam PF02465 Flagellar hook-associated protein 2 N-terminus 13 106 1.0E-11 T 13-10-2018 IPR003481 Flagellar hook-associated protein 2, N-terminal GO:0009424 TOPB45_1630 db636b649f2beacaae7c12825b5dbc88 434 Pfam PF07195 Flagellar hook-associated protein 2 C-terminus 219 412 1.5E-14 T 13-10-2018 IPR010809 Flagellar hook-associated protein 2, C-terminal GO:0007155|GO:0009288 TOPB45_1021 24904b46846e8141b0423f6f827331dc 202 Pfam PF01966 HD domain 22 100 5.2E-6 T 13-10-2018 IPR006674 HD domain TOPB45_1021 24904b46846e8141b0423f6f827331dc 202 SMART SM00471 17 131 2.1E-5 T 13-10-2018 IPR003607 HD/PDEase domain TOPB45_1021 24904b46846e8141b0423f6f827331dc 202 SUPERFAMILY SSF109604 15 120 8.85E-15 T 13-10-2018 TOPB45_1021 24904b46846e8141b0423f6f827331dc 202 TIGRFAM TIGR00277 HDIG: HDIG domain 19 96 3.8E-7 T 13-10-2018 IPR006675 HDIG domain TOPB45_1021 24904b46846e8141b0423f6f827331dc 202 Gene3D G3DSA:1.10.3210.10 6 156 1.1E-13 T 13-10-2018 TOPB45_1215 e8aa2e6cbff41c84fef9443f44b126f4 377 Pfam PF01702 Queuine tRNA-ribosyltransferase 131 364 1.3E-81 T 13-10-2018 IPR002616 tRNA-guanine(15) transglycosylase-like GO:0006400|GO:0016763 MetaCyc: PWY-6700|Reactome: R-HSA-6782315 TOPB45_1215 e8aa2e6cbff41c84fef9443f44b126f4 377 Gene3D G3DSA:3.20.20.105 1 373 1.0E-157 T 13-10-2018 IPR036511 Queuine tRNA-ribosyltransferase-like GO:0006400|GO:0016763 MetaCyc: PWY-6700|Reactome: R-HSA-6782315 TOPB45_1215 e8aa2e6cbff41c84fef9443f44b126f4 377 SUPERFAMILY SSF51713 1 369 7.32E-146 T 13-10-2018 IPR036511 Queuine tRNA-ribosyltransferase-like GO:0006400|GO:0016763 MetaCyc: PWY-6700|Reactome: R-HSA-6782315 TOPB45_1215 e8aa2e6cbff41c84fef9443f44b126f4 377 Hamap MF_00168 Queuine tRNA-ribosyltransferase [tgt]. 2 368 51.857 T 13-10-2018 IPR004803 tRNA-guanine transglycosylase GO:0008479|GO:0101030 MetaCyc: PWY-6700|Reactome: R-HSA-6782315 TOPB45_1215 e8aa2e6cbff41c84fef9443f44b126f4 377 TIGRFAM TIGR00430 Q_tRNA_tgt: tRNA-guanine transglycosylase 9 369 1.4E-155 T 13-10-2018 IPR004803 tRNA-guanine transglycosylase GO:0008479|GO:0101030 MetaCyc: PWY-6700|Reactome: R-HSA-6782315 TOPB45_1215 e8aa2e6cbff41c84fef9443f44b126f4 377 TIGRFAM TIGR00449 tgt_general: tRNA-guanine family transglycosylase 9 369 1.2E-147 T 13-10-2018 IPR002616 tRNA-guanine(15) transglycosylase-like GO:0006400|GO:0016763 MetaCyc: PWY-6700|Reactome: R-HSA-6782315 TOPB45_0123 e15fab6a48e7fe3f7f26aec412b92836 389 Gene3D G3DSA:1.10.1510.30 147 237 1.9E-51 T 13-10-2018 TOPB45_0123 e15fab6a48e7fe3f7f26aec412b92836 389 Pfam PF01142 tRNA pseudouridine synthase D (TruD) 2 381 5.3E-58 T 13-10-2018 IPR001656 Pseudouridine synthase, TruD GO:0001522|GO:0003723|GO:0009451|GO:0009982 TOPB45_0123 e15fab6a48e7fe3f7f26aec412b92836 389 Gene3D G3DSA:3.30.2350.20 104 380 1.9E-51 T 13-10-2018 TOPB45_0123 e15fab6a48e7fe3f7f26aec412b92836 389 Gene3D G3DSA:3.30.70.3160 21 103 1.9E-51 T 13-10-2018 TOPB45_0123 e15fab6a48e7fe3f7f26aec412b92836 389 PIRSF PIRSF037016 7 261 4.4E-31 T 13-10-2018 IPR001656 Pseudouridine synthase, TruD GO:0001522|GO:0003723|GO:0009451|GO:0009982 TOPB45_0123 e15fab6a48e7fe3f7f26aec412b92836 389 PIRSF PIRSF037016 284 384 0.2 T 13-10-2018 IPR001656 Pseudouridine synthase, TruD GO:0001522|GO:0003723|GO:0009451|GO:0009982 TOPB45_0123 e15fab6a48e7fe3f7f26aec412b92836 389 SUPERFAMILY SSF55120 2 383 3.31E-57 T 13-10-2018 IPR020103 Pseudouridine synthase, catalytic domain superfamily GO:0001522|GO:0003723|GO:0009451|GO:0009982 TOPB45_0380 88d312a38df930839d9111d50fb21be2 262 Gene3D G3DSA:3.30.70.20 139 198 5.7E-15 T 13-10-2018 TOPB45_0380 88d312a38df930839d9111d50fb21be2 262 SUPERFAMILY SSF54862 117 193 1.37E-17 T 13-10-2018 TOPB45_0380 88d312a38df930839d9111d50fb21be2 262 SUPERFAMILY SSF56014 63 261 4.45E-31 T 13-10-2018 TOPB45_0380 88d312a38df930839d9111d50fb21be2 262 Pfam PF13187 4Fe-4S dicluster domain 146 190 7.1E-7 T 13-10-2018 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain TOPB45_0380 88d312a38df930839d9111d50fb21be2 262 Gene3D G3DSA:1.10.8.550 1 51 8.8E-20 T 13-10-2018 TOPB45_0380 88d312a38df930839d9111d50fb21be2 262 Pfam PF08369 Proto-chlorophyllide reductase 57 kD subunit 3 47 1.6E-18 T 13-10-2018 IPR013580 Proto-chlorophyllide/chlorophyllide reductase, C-terminal GO:0015979|GO:0015995|GO:0016491|GO:0055114 KEGG: 00860+1.3.7.7|MetaCyc: PWY-5531|MetaCyc: PWY-7159 TOPB45_0380 88d312a38df930839d9111d50fb21be2 262 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 176 187 - T 13-10-2018 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site TOPB45_0380 88d312a38df930839d9111d50fb21be2 262 Pfam PF01077 Nitrite and sulphite reductase 4Fe-4S domain 62 261 5.3E-23 T 13-10-2018 IPR006067 Nitrite/sulphite reductase 4Fe-4S domain GO:0016491|GO:0020037|GO:0051536|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 TOPB45_1412 d7cfa9a11f0b4e5f43c1c43f7a706ba3 65 Gene3D G3DSA:2.30.170.40 24 65 1.5E-22 T 13-10-2018 IPR037147 Ribosomal protein L28/L24 superfamily GO:0003735 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_1412 d7cfa9a11f0b4e5f43c1c43f7a706ba3 65 SUPERFAMILY SSF143800 1 63 3.14E-25 T 13-10-2018 IPR034704 L28p-like Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_1412 d7cfa9a11f0b4e5f43c1c43f7a706ba3 65 TIGRFAM TIGR00009 L28: ribosomal protein bL28 1 57 5.1E-24 T 13-10-2018 IPR001383 Ribosomal protein L28 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_1412 d7cfa9a11f0b4e5f43c1c43f7a706ba3 65 Gene3D G3DSA:2.20.150.30 1 23 6.1E-5 T 13-10-2018 TOPB45_1412 d7cfa9a11f0b4e5f43c1c43f7a706ba3 65 Hamap MF_00373 50S ribosomal protein L28 [rpmB]. 1 63 19.968 T 13-10-2018 IPR001383 Ribosomal protein L28 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_1412 d7cfa9a11f0b4e5f43c1c43f7a706ba3 65 Pfam PF00830 Ribosomal L28 family 3 59 2.1E-24 T 13-10-2018 IPR026569 Ribosomal protein L28/L24 GO:0003735 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0165 37493b27bafbe92c101322be785484ae 129 Hamap MF_00368 50S ribosomal protein L7/L12 [rplL]. 2 129 26.13 T 13-10-2018 IPR000206 Ribosomal protein L7/L12 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0165 37493b27bafbe92c101322be785484ae 129 Pfam PF00542 Ribosomal protein L7/L12 C-terminal domain 63 129 1.5E-32 T 13-10-2018 IPR013823 Ribosomal protein L7/L12, C-terminal GO:0003735|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0165 37493b27bafbe92c101322be785484ae 129 SUPERFAMILY SSF54736 58 129 8.55E-27 T 13-10-2018 IPR014719 Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like TOPB45_0165 37493b27bafbe92c101322be785484ae 129 ProDom PD001326 RIBOSOMAL L7/L12 50S RIBONUCLEOPROTEIN CHLOROPLAST L12 PLASTID DIRECT SEQUENCING PEPTIDE 64 129 2.0E-21 T 13-10-2018 IPR013823 Ribosomal protein L7/L12, C-terminal GO:0003735|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0165 37493b27bafbe92c101322be785484ae 129 Gene3D G3DSA:1.20.5.710 3 58 5.6E-21 T 13-10-2018 TOPB45_0165 37493b27bafbe92c101322be785484ae 129 SUPERFAMILY SSF48300 4 65 4.05E-15 T 13-10-2018 IPR036235 Ribosomal protein L7/L12, oligomerisation domain superfamily GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0165 37493b27bafbe92c101322be785484ae 129 Pfam PF16320 Ribosomal protein L7/L12 dimerisation domain 4 51 4.8E-19 T 13-10-2018 IPR008932 Ribosomal protein L7/L12, oligomerisation GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0165 37493b27bafbe92c101322be785484ae 129 TIGRFAM TIGR00855 L12: ribosomal protein bL12 3 129 3.1E-50 T 13-10-2018 IPR000206 Ribosomal protein L7/L12 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0165 37493b27bafbe92c101322be785484ae 129 Gene3D G3DSA:3.30.1390.10 59 129 7.2E-34 T 13-10-2018 IPR014719 Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like TOPB45_0292 69d3fd6f4af16ff1db7494822cbc9c4a 148 SUPERFAMILY SSF75169 6 144 1.33E-17 T 13-10-2018 IPR027396 DsrEFH-like TOPB45_0292 69d3fd6f4af16ff1db7494822cbc9c4a 148 Gene3D G3DSA:3.40.1260.10 1 148 3.5E-30 T 13-10-2018 IPR027396 DsrEFH-like TOPB45_0292 69d3fd6f4af16ff1db7494822cbc9c4a 148 Pfam PF13686 DsrE/DsrF/DrsH-like family 5 147 3.9E-29 T 13-10-2018 IPR032836 DsrE2-like family TOPB45_1276 3993e6b70ace5dca791321e82b6ee0cf 1087 SMART SM01096 427 550 5.5E-70 T 13-10-2018 IPR005480 Carbamoyl-phosphate synthetase, large subunit oligomerisation domain KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400|MetaCyc: PWY-7790|MetaCyc: PWY-7791 TOPB45_1276 3993e6b70ace5dca791321e82b6ee0cf 1087 ProSitePatterns PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 297 304 - T 13-10-2018 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 TOPB45_1276 3993e6b70ace5dca791321e82b6ee0cf 1087 SMART SM00851 958 1045 2.9E-27 T 13-10-2018 IPR011607 Methylglyoxal synthase-like domain TOPB45_1276 3993e6b70ace5dca791321e82b6ee0cf 1087 Pfam PF02142 MGS-like domain 959 1045 5.5E-19 T 13-10-2018 IPR011607 Methylglyoxal synthase-like domain TOPB45_1276 3993e6b70ace5dca791321e82b6ee0cf 1087 Hamap MF_01210_B Carbamoyl-phosphate synthase large chain [carB]. 1 1066 13.097 T 13-10-2018 IPR006275 Carbamoyl-phosphate synthase, large subunit GO:0006807 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400|MetaCyc: PWY-7790|MetaCyc: PWY-7791 TOPB45_1276 3993e6b70ace5dca791321e82b6ee0cf 1087 Gene3D G3DSA:3.40.50.20 1 116 4.6E-49 T 13-10-2018 TOPB45_1276 3993e6b70ace5dca791321e82b6ee0cf 1087 Pfam PF02787 Carbamoyl-phosphate synthetase large chain, oligomerisation domain 430 550 2.7E-43 T 13-10-2018 IPR005480 Carbamoyl-phosphate synthetase, large subunit oligomerisation domain KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400|MetaCyc: PWY-7790|MetaCyc: PWY-7791 TOPB45_1276 3993e6b70ace5dca791321e82b6ee0cf 1087 SUPERFAMILY SSF56059 129 400 2.65E-108 T 13-10-2018 TOPB45_1276 3993e6b70ace5dca791321e82b6ee0cf 1087 SUPERFAMILY SSF52440 561 678 4.46E-50 T 13-10-2018 IPR016185 Pre-ATP-grasp domain superfamily TOPB45_1276 3993e6b70ace5dca791321e82b6ee0cf 1087 PRINTS PR00098 Carbamoyl-phosphate synthase protein CPSase domain signature 204 223 3.2E-65 T 13-10-2018 IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain GO:0006807 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400|MetaCyc: PWY-7790|MetaCyc: PWY-7791 TOPB45_1276 3993e6b70ace5dca791321e82b6ee0cf 1087 PRINTS PR00098 Carbamoyl-phosphate synthase protein CPSase domain signature 239 256 3.2E-65 T 13-10-2018 IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain GO:0006807 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400|MetaCyc: PWY-7790|MetaCyc: PWY-7791 TOPB45_1276 3993e6b70ace5dca791321e82b6ee0cf 1087 PRINTS PR00098 Carbamoyl-phosphate synthase protein CPSase domain signature 297 326 3.2E-65 T 13-10-2018 IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain GO:0006807 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400|MetaCyc: PWY-7790|MetaCyc: PWY-7791 TOPB45_1276 3993e6b70ace5dca791321e82b6ee0cf 1087 PRINTS PR00098 Carbamoyl-phosphate synthase protein CPSase domain signature 168 180 3.2E-65 T 13-10-2018 IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain GO:0006807 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400|MetaCyc: PWY-7790|MetaCyc: PWY-7791 TOPB45_1276 3993e6b70ace5dca791321e82b6ee0cf 1087 PRINTS PR00098 Carbamoyl-phosphate synthase protein CPSase domain signature 48 58 3.2E-65 T 13-10-2018 IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain GO:0006807 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400|MetaCyc: PWY-7790|MetaCyc: PWY-7791 TOPB45_1276 3993e6b70ace5dca791321e82b6ee0cf 1087 PRINTS PR00098 Carbamoyl-phosphate synthase protein CPSase domain signature 19 33 3.2E-65 T 13-10-2018 IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain GO:0006807 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400|MetaCyc: PWY-7790|MetaCyc: PWY-7791 TOPB45_1276 3993e6b70ace5dca791321e82b6ee0cf 1087 PRINTS PR00098 Carbamoyl-phosphate synthase protein CPSase domain signature 379 397 3.2E-65 T 13-10-2018 IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain GO:0006807 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400|MetaCyc: PWY-7790|MetaCyc: PWY-7791 TOPB45_1276 3993e6b70ace5dca791321e82b6ee0cf 1087 Hamap MF_01210_A Carbamoyl-phosphate synthase large chain [carB]. 5 1073 13.888 T 13-10-2018 IPR006275 Carbamoyl-phosphate synthase, large subunit GO:0006807 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400|MetaCyc: PWY-7790|MetaCyc: PWY-7791 TOPB45_1276 3993e6b70ace5dca791321e82b6ee0cf 1087 Gene3D G3DSA:3.40.50.20 557 665 6.5E-48 T 13-10-2018 TOPB45_1276 3993e6b70ace5dca791321e82b6ee0cf 1087 SUPERFAMILY SSF48108 395 556 5.75E-53 T 13-10-2018 IPR036897 Carbamoyl-phosphate synthetase, large subunit oligomerisation domain superfamily KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400|MetaCyc: PWY-7790|MetaCyc: PWY-7791 TOPB45_1276 3993e6b70ace5dca791321e82b6ee0cf 1087 ProSitePatterns PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 164 178 - T 13-10-2018 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 TOPB45_1276 3993e6b70ace5dca791321e82b6ee0cf 1087 SUPERFAMILY SSF52440 1 127 1.29E-48 T 13-10-2018 IPR016185 Pre-ATP-grasp domain superfamily TOPB45_1276 3993e6b70ace5dca791321e82b6ee0cf 1087 SUPERFAMILY SSF52335 938 1076 6.15E-37 T 13-10-2018 IPR036914 Methylglyoxal synthase-like domain superfamily TOPB45_1276 3993e6b70ace5dca791321e82b6ee0cf 1087 Pfam PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 129 334 3.8E-72 T 13-10-2018 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 TOPB45_1276 3993e6b70ace5dca791321e82b6ee0cf 1087 Pfam PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 676 877 1.9E-35 T 13-10-2018 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 TOPB45_1276 3993e6b70ace5dca791321e82b6ee0cf 1087 SUPERFAMILY SSF56059 676 936 1.77E-102 T 13-10-2018 TOPB45_1276 3993e6b70ace5dca791321e82b6ee0cf 1087 TIGRFAM TIGR01369 CPSaseII_lrg: carbamoyl-phosphate synthase, large subunit 2 1056 0.0 T 13-10-2018 IPR006275 Carbamoyl-phosphate synthase, large subunit GO:0006807 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400|MetaCyc: PWY-7790|MetaCyc: PWY-7791 TOPB45_1276 3993e6b70ace5dca791321e82b6ee0cf 1087 ProSitePatterns PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 841 848 - T 13-10-2018 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 TOPB45_1276 3993e6b70ace5dca791321e82b6ee0cf 1087 Gene3D G3DSA:3.30.470.20 119 402 1.3E-124 T 13-10-2018 TOPB45_1276 3993e6b70ace5dca791321e82b6ee0cf 1087 Gene3D G3DSA:3.40.50.1380 939 1077 7.9E-42 T 13-10-2018 IPR036914 Methylglyoxal synthase-like domain superfamily TOPB45_1276 3993e6b70ace5dca791321e82b6ee0cf 1087 Gene3D G3DSA:1.10.1030.10 410 556 8.0E-49 T 13-10-2018 IPR036897 Carbamoyl-phosphate synthetase, large subunit oligomerisation domain superfamily KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400|MetaCyc: PWY-7790|MetaCyc: PWY-7791 TOPB45_1276 3993e6b70ace5dca791321e82b6ee0cf 1087 ProSitePatterns PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 712 726 - T 13-10-2018 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 TOPB45_1276 3993e6b70ace5dca791321e82b6ee0cf 1087 Gene3D G3DSA:3.30.470.20 668 938 6.9E-117 T 13-10-2018 TOPB45_1326 0dc0a180ef0512e34db27be5c2b49bc6 245 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 16 242 6.8E-34 T 13-10-2018 IPR014284 RNA polymerase sigma-70 like domain GO:0003700|GO:0006352|GO:0006355 TOPB45_1326 0dc0a180ef0512e34db27be5c2b49bc6 245 Gene3D G3DSA:1.20.140.160 90 245 2.3E-43 T 13-10-2018 TOPB45_1326 0dc0a180ef0512e34db27be5c2b49bc6 245 SUPERFAMILY SSF88659 163 244 2.62E-22 T 13-10-2018 IPR013324 RNA polymerase sigma factor, region 3/4-like TOPB45_1326 0dc0a180ef0512e34db27be5c2b49bc6 245 PRINTS PR00046 Major sigma-70 factor signature 213 228 6.4E-13 T 13-10-2018 IPR000943 RNA polymerase sigma-70 GO:0003700|GO:0006352|GO:0006355 TOPB45_1326 0dc0a180ef0512e34db27be5c2b49bc6 245 PRINTS PR00046 Major sigma-70 factor signature 70 78 6.4E-13 T 13-10-2018 IPR000943 RNA polymerase sigma-70 GO:0003700|GO:0006352|GO:0006355 TOPB45_1326 0dc0a180ef0512e34db27be5c2b49bc6 245 PRINTS PR00046 Major sigma-70 factor signature 196 208 6.4E-13 T 13-10-2018 IPR000943 RNA polymerase sigma-70 GO:0003700|GO:0006352|GO:0006355 TOPB45_1326 0dc0a180ef0512e34db27be5c2b49bc6 245 PRINTS PR00046 Major sigma-70 factor signature 46 59 6.4E-13 T 13-10-2018 IPR000943 RNA polymerase sigma-70 GO:0003700|GO:0006352|GO:0006355 TOPB45_1326 0dc0a180ef0512e34db27be5c2b49bc6 245 PRINTS PR00046 Major sigma-70 factor signature 228 239 6.4E-13 T 13-10-2018 IPR000943 RNA polymerase sigma-70 GO:0003700|GO:0006352|GO:0006355 TOPB45_1326 0dc0a180ef0512e34db27be5c2b49bc6 245 Pfam PF04542 Sigma-70 region 2 19 89 4.7E-14 T 13-10-2018 IPR007627 RNA polymerase sigma-70 region 2 GO:0003700|GO:0006352|GO:0006355 TOPB45_1326 0dc0a180ef0512e34db27be5c2b49bc6 245 Pfam PF04545 Sigma-70, region 4 192 240 4.2E-18 T 13-10-2018 IPR007630 RNA polymerase sigma-70 region 4 GO:0003700|GO:0006352|GO:0006355 TOPB45_1326 0dc0a180ef0512e34db27be5c2b49bc6 245 PIRSF PIRSF000770 6 245 6.7E-40 T 13-10-2018 IPR000943 RNA polymerase sigma-70 GO:0003700|GO:0006352|GO:0006355 TOPB45_1326 0dc0a180ef0512e34db27be5c2b49bc6 245 SUPERFAMILY SSF88659 92 151 2.27E-12 T 13-10-2018 IPR013324 RNA polymerase sigma factor, region 3/4-like TOPB45_1326 0dc0a180ef0512e34db27be5c2b49bc6 245 SUPERFAMILY SSF88946 16 90 1.18E-21 T 13-10-2018 IPR013325 RNA polymerase sigma factor, region 2 GO:0003700|GO:0006352|GO:0006355 TOPB45_1326 0dc0a180ef0512e34db27be5c2b49bc6 245 Gene3D G3DSA:1.10.1740.10 4 89 5.2E-25 T 13-10-2018 TOPB45_1326 0dc0a180ef0512e34db27be5c2b49bc6 245 Pfam PF04539 Sigma-70 region 3 108 150 3.1E-9 T 13-10-2018 IPR007624 RNA polymerase sigma-70 region 3 GO:0003700|GO:0006352|GO:0006355 TOPB45_1326 0dc0a180ef0512e34db27be5c2b49bc6 245 TIGRFAM TIGR02479 FliA_WhiG: RNA polymerase sigma factor, FliA/WhiG family 19 243 3.5E-72 T 13-10-2018 IPR012845 RNA polymerase sigma factor, FliA/WhiG GO:0003677|GO:0003899|GO:0006352|GO:0006355|GO:0016987 TOPB45_1037 8409e48ed7e2b20eed91d8e142a71479 881 Gene3D G3DSA:1.10.730.10 6 744 0.0 T 13-10-2018 TOPB45_1037 8409e48ed7e2b20eed91d8e142a71479 881 PRINTS PR00986 Valyl-tRNA synthetase signature 40 51 1.2E-37 T 13-10-2018 IPR002303 Valine-tRNA ligase GO:0000166|GO:0004832|GO:0005524|GO:0006438 KEGG: 00970+6.1.1.9 TOPB45_1037 8409e48ed7e2b20eed91d8e142a71479 881 PRINTS PR00986 Valyl-tRNA synthetase signature 448 469 1.2E-37 T 13-10-2018 IPR002303 Valine-tRNA ligase GO:0000166|GO:0004832|GO:0005524|GO:0006438 KEGG: 00970+6.1.1.9 TOPB45_1037 8409e48ed7e2b20eed91d8e142a71479 881 PRINTS PR00986 Valyl-tRNA synthetase signature 479 497 1.2E-37 T 13-10-2018 IPR002303 Valine-tRNA ligase GO:0000166|GO:0004832|GO:0005524|GO:0006438 KEGG: 00970+6.1.1.9 TOPB45_1037 8409e48ed7e2b20eed91d8e142a71479 881 PRINTS PR00986 Valyl-tRNA synthetase signature 349 362 1.2E-37 T 13-10-2018 IPR002303 Valine-tRNA ligase GO:0000166|GO:0004832|GO:0005524|GO:0006438 KEGG: 00970+6.1.1.9 TOPB45_1037 8409e48ed7e2b20eed91d8e142a71479 881 PRINTS PR00986 Valyl-tRNA synthetase signature 234 251 1.2E-37 T 13-10-2018 IPR002303 Valine-tRNA ligase GO:0000166|GO:0004832|GO:0005524|GO:0006438 KEGG: 00970+6.1.1.9 TOPB45_1037 8409e48ed7e2b20eed91d8e142a71479 881 SUPERFAMILY SSF46589 816 880 2.3E-13 T 13-10-2018 IPR010978 Class I and II aminoacyl-tRNA synthetase, tRNA-binding arm GO:0000166 TOPB45_1037 8409e48ed7e2b20eed91d8e142a71479 881 Gene3D G3DSA:3.90.740.10 179 346 0.0 T 13-10-2018 IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain GO:0002161|GO:0006418 TOPB45_1037 8409e48ed7e2b20eed91d8e142a71479 881 SUPERFAMILY SSF50677 196 344 1.83E-62 T 13-10-2018 IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain GO:0002161|GO:0006418 TOPB45_1037 8409e48ed7e2b20eed91d8e142a71479 881 Hamap MF_02004 Valine--tRNA ligase [valS]. 6 881 16.039 T 13-10-2018 IPR002303 Valine-tRNA ligase GO:0000166|GO:0004832|GO:0005524|GO:0006438 KEGG: 00970+6.1.1.9 TOPB45_1037 8409e48ed7e2b20eed91d8e142a71479 881 Gene3D G3DSA:1.10.287.380 809 881 9.1E-18 T 13-10-2018 IPR037118 Valyl-tRNA synthetase, tRNA-binding arm superfamily GO:0000166|GO:0004832|GO:0005524|GO:0005737|GO:0006438 KEGG: 00970+6.1.1.9|Reactome: R-HSA-379716 TOPB45_1037 8409e48ed7e2b20eed91d8e142a71479 881 SUPERFAMILY SSF52374 7 576 9.19E-149 T 13-10-2018 TOPB45_1037 8409e48ed7e2b20eed91d8e142a71479 881 SUPERFAMILY SSF47323 578 831 1.68E-66 T 13-10-2018 IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 TOPB45_1037 8409e48ed7e2b20eed91d8e142a71479 881 Pfam PF00133 tRNA synthetases class I (I, L, M and V) 18 567 1.2E-214 T 13-10-2018 IPR002300 Aminoacyl-tRNA synthetase, class Ia GO:0000166|GO:0004812|GO:0005524|GO:0006418 TOPB45_1037 8409e48ed7e2b20eed91d8e142a71479 881 Pfam PF10458 Valyl tRNA synthetase tRNA binding arm 816 881 2.9E-13 T 13-10-2018 IPR019499 Valyl-tRNA synthetase, tRNA-binding arm GO:0000166|GO:0004832|GO:0005524|GO:0005737|GO:0006438 KEGG: 00970+6.1.1.9 TOPB45_1037 8409e48ed7e2b20eed91d8e142a71479 881 Gene3D G3DSA:3.40.50.620 26 528 0.0 T 13-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TOPB45_1037 8409e48ed7e2b20eed91d8e142a71479 881 ProSitePatterns PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 47 58 - T 13-10-2018 IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site GO:0000166|GO:0004812|GO:0005524|GO:0006418 TOPB45_1037 8409e48ed7e2b20eed91d8e142a71479 881 Pfam PF08264 Anticodon-binding domain of tRNA 612 755 1.2E-38 T 13-10-2018 IPR013155 Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding GO:0004812|GO:0006418 TOPB45_1037 8409e48ed7e2b20eed91d8e142a71479 881 TIGRFAM TIGR00422 valS: valine--tRNA ligase 7 862 0.0 T 13-10-2018 IPR002303 Valine-tRNA ligase GO:0000166|GO:0004832|GO:0005524|GO:0006438 KEGG: 00970+6.1.1.9 TOPB45_1027 c0becd76f02d13a206705be97389e100 864 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 508 518 5.4E-39 T 13-10-2018 TOPB45_1027 c0becd76f02d13a206705be97389e100 864 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 167 181 5.4E-39 T 13-10-2018 TOPB45_1027 c0becd76f02d13a206705be97389e100 864 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 486 497 5.4E-39 T 13-10-2018 TOPB45_1027 c0becd76f02d13a206705be97389e100 864 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 589 608 5.4E-39 T 13-10-2018 TOPB45_1027 c0becd76f02d13a206705be97389e100 864 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 612 624 5.4E-39 T 13-10-2018 TOPB45_1027 c0becd76f02d13a206705be97389e100 864 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 327 341 5.4E-39 T 13-10-2018 TOPB45_1027 c0becd76f02d13a206705be97389e100 864 PRINTS PR00120 H+-transporting ATPase (proton pump) signature 620 645 7.0E-14 T 13-10-2018 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 TOPB45_1027 c0becd76f02d13a206705be97389e100 864 PRINTS PR00120 H+-transporting ATPase (proton pump) signature 454 472 7.0E-14 T 13-10-2018 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 TOPB45_1027 c0becd76f02d13a206705be97389e100 864 PRINTS PR00120 H+-transporting ATPase (proton pump) signature 589 605 7.0E-14 T 13-10-2018 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 TOPB45_1027 c0becd76f02d13a206705be97389e100 864 ProSitePatterns PS00154 E1-E2 ATPases phosphorylation site. 329 335 - T 13-10-2018 IPR018303 P-type ATPase, phosphorylation site Reactome: R-HSA-936837 TOPB45_1027 c0becd76f02d13a206705be97389e100 864 Pfam PF00690 Cation transporter/ATPase, N-terminus 5 69 6.6E-17 T 13-10-2018 IPR004014 Cation-transporting P-type ATPase, N-terminal Reactome: R-HSA-936837 TOPB45_1027 c0becd76f02d13a206705be97389e100 864 SMART SM00831 2 75 8.9E-21 T 13-10-2018 IPR004014 Cation-transporting P-type ATPase, N-terminal Reactome: R-HSA-936837 TOPB45_1027 c0becd76f02d13a206705be97389e100 864 Pfam PF00702 haloacid dehalogenase-like hydrolase 323 603 7.1E-24 T 13-10-2018 TOPB45_1027 c0becd76f02d13a206705be97389e100 864 SUPERFAMILY SSF81660 335 490 1.63E-39 T 13-10-2018 IPR023299 P-type ATPase, cytoplasmic domain N GO:0000166 Reactome: R-HSA-936837 TOPB45_1027 c0becd76f02d13a206705be97389e100 864 Gene3D G3DSA:3.40.1110.10 337 493 1.1E-279 T 13-10-2018 IPR023299 P-type ATPase, cytoplasmic domain N GO:0000166 Reactome: R-HSA-936837 TOPB45_1027 c0becd76f02d13a206705be97389e100 864 SUPERFAMILY SSF81665 6 861 1.2E-123 T 13-10-2018 IPR023298 P-type ATPase, transmembrane domain superfamily Reactome: R-HSA-936837 TOPB45_1027 c0becd76f02d13a206705be97389e100 864 Gene3D G3DSA:3.40.50.1000 324 633 1.1E-279 T 13-10-2018 IPR023214 HAD superfamily TOPB45_1027 c0becd76f02d13a206705be97389e100 864 SUPERFAMILY SSF81653 119 226 1.03E-27 T 13-10-2018 IPR008250 P-type ATPase, A domain superfamily Reactome: R-HSA-936837 TOPB45_1027 c0becd76f02d13a206705be97389e100 864 SUPERFAMILY SSF56784 325 693 8.93E-60 T 13-10-2018 IPR036412 HAD-like superfamily TOPB45_1027 c0becd76f02d13a206705be97389e100 864 Pfam PF00689 Cation transporting ATPase, C-terminus 672 857 1.4E-50 T 13-10-2018 IPR006068 Cation-transporting P-type ATPase, C-terminal Reactome: R-HSA-936837 TOPB45_1027 c0becd76f02d13a206705be97389e100 864 Pfam PF00122 E1-E2 ATPase 117 307 4.3E-51 T 13-10-2018 TOPB45_1027 c0becd76f02d13a206705be97389e100 864 Gene3D G3DSA:1.20.1110.10 53 856 1.1E-279 T 13-10-2018 TOPB45_1027 c0becd76f02d13a206705be97389e100 864 Gene3D G3DSA:2.70.150.10 18 230 1.1E-279 T 13-10-2018 TOPB45_1027 c0becd76f02d13a206705be97389e100 864 TIGRFAM TIGR01494 ATPase_P-type: HAD ATPase, P-type, family IC 89 361 3.1E-43 T 13-10-2018 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 TOPB45_1027 c0becd76f02d13a206705be97389e100 864 TIGRFAM TIGR01494 ATPase_P-type: HAD ATPase, P-type, family IC 563 676 3.3E-35 T 13-10-2018 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 TOPB45_1027 c0becd76f02d13a206705be97389e100 864 TIGRFAM TIGR01494 ATPase_P-type: HAD ATPase, P-type, family IC 369 533 1.8E-21 T 13-10-2018 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 TOPB45_0788 9e564e8d4717eb67a7d42d394fd064ff 446 TIGRFAM TIGR00767 rho: transcription termination factor Rho 32 446 1.4E-201 T 13-10-2018 IPR004665 Transcription termination factor Rho GO:0003723|GO:0005524|GO:0006353|GO:0008186 TOPB45_0788 9e564e8d4717eb67a7d42d394fd064ff 446 Pfam PF07498 Rho termination factor, N-terminal domain 34 70 4.1E-7 T 13-10-2018 IPR011112 Rho termination factor, N-terminal GO:0006353 TOPB45_0788 9e564e8d4717eb67a7d42d394fd064ff 446 SMART SM00382 197 383 1.2E-8 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_0788 9e564e8d4717eb67a7d42d394fd064ff 446 Gene3D G3DSA:3.40.50.300 160 445 3.3E-126 T 13-10-2018 TOPB45_0788 9e564e8d4717eb67a7d42d394fd064ff 446 Gene3D G3DSA:2.40.50.140 28 159 1.2E-43 T 13-10-2018 TOPB45_0788 9e564e8d4717eb67a7d42d394fd064ff 446 SUPERFAMILY SSF50249 79 155 1.16E-26 T 13-10-2018 IPR012340 Nucleic acid-binding, OB-fold TOPB45_0788 9e564e8d4717eb67a7d42d394fd064ff 446 SMART SM00959 34 77 2.6E-4 T 13-10-2018 IPR011112 Rho termination factor, N-terminal GO:0006353 TOPB45_0788 9e564e8d4717eb67a7d42d394fd064ff 446 SMART SM00357 82 148 9.3E-17 T 13-10-2018 IPR011129 Cold shock domain GO:0003676 TOPB45_0788 9e564e8d4717eb67a7d42d394fd064ff 446 Hamap MF_01884 Transcription termination factor Rho [rho]. 32 446 214.87 T 13-10-2018 IPR004665 Transcription termination factor Rho GO:0003723|GO:0005524|GO:0006353|GO:0008186 TOPB45_0788 9e564e8d4717eb67a7d42d394fd064ff 446 Pfam PF07497 Rho termination factor, RNA-binding domain 81 155 7.5E-30 T 13-10-2018 IPR011113 Rho termination factor, RNA-binding domain GO:0003723|GO:0006353 TOPB45_0788 9e564e8d4717eb67a7d42d394fd064ff 446 Pfam PF00006 ATP synthase alpha/beta family, nucleotide-binding domain 186 391 1.5E-23 T 13-10-2018 IPR000194 ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain GO:0005524 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7980 TOPB45_0788 9e564e8d4717eb67a7d42d394fd064ff 446 SUPERFAMILY SSF52540 120 399 1.9E-68 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0788 9e564e8d4717eb67a7d42d394fd064ff 446 SUPERFAMILY SSF68912 32 71 3.61E-5 T 13-10-2018 IPR036269 Rho termination factor, N-terminal domain superfamily TOPB45_0208 2456e2721fdc828fa605ca27004d90a2 252 SMART SM00671 202 233 60.0 T 13-10-2018 IPR006597 Sel1-like repeat TOPB45_0208 2456e2721fdc828fa605ca27004d90a2 252 SMART SM00671 168 199 26.0 T 13-10-2018 IPR006597 Sel1-like repeat TOPB45_0208 2456e2721fdc828fa605ca27004d90a2 252 SMART SM00671 98 129 10.0 T 13-10-2018 IPR006597 Sel1-like repeat TOPB45_0208 2456e2721fdc828fa605ca27004d90a2 252 SUPERFAMILY SSF48452 38 238 7.59E-34 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_0208 2456e2721fdc828fa605ca27004d90a2 252 Gene3D G3DSA:1.25.40.10 192 249 1.3E-8 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_0208 2456e2721fdc828fa605ca27004d90a2 252 Pfam PF14559 Tetratricopeptide repeat 180 240 2.2E-9 T 13-10-2018 TOPB45_0208 2456e2721fdc828fa605ca27004d90a2 252 Gene3D G3DSA:1.25.40.10 24 191 7.0E-44 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_0208 2456e2721fdc828fa605ca27004d90a2 252 SMART SM00028 98 131 5.7E-5 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_0208 2456e2721fdc828fa605ca27004d90a2 252 SMART SM00028 134 167 0.024 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_0208 2456e2721fdc828fa605ca27004d90a2 252 SMART SM00028 30 63 170.0 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_0208 2456e2721fdc828fa605ca27004d90a2 252 SMART SM00028 64 97 4.3E-6 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_0208 2456e2721fdc828fa605ca27004d90a2 252 SMART SM00028 168 201 1.2E-4 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_0208 2456e2721fdc828fa605ca27004d90a2 252 SMART SM00028 202 235 0.0036 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_0208 2456e2721fdc828fa605ca27004d90a2 252 Pfam PF00515 Tetratricopeptide repeat 99 126 9.8E-10 T 13-10-2018 IPR001440 Tetratricopeptide repeat 1 GO:0005515 TOPB45_0208 2456e2721fdc828fa605ca27004d90a2 252 Pfam PF00515 Tetratricopeptide repeat 64 97 6.0E-7 T 13-10-2018 IPR001440 Tetratricopeptide repeat 1 GO:0005515 TOPB45_0208 2456e2721fdc828fa605ca27004d90a2 252 Pfam PF13181 Tetratricopeptide repeat 138 165 0.0025 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_0774 ae2309a665c35a0c1f15d46a6aa6c278 215 ProSitePatterns PS00113 Adenylate kinase signature. 81 92 - T 13-10-2018 IPR033690 Adenylate kinase, conserved site KEGG: 00230+2.7.4.3|KEGG: 00730+2.7.4.3|MetaCyc: PWY-7219|Reactome: R-HSA-499943 TOPB45_0774 ae2309a665c35a0c1f15d46a6aa6c278 215 Pfam PF00406 Adenylate kinase 6 190 5.8E-63 T 13-10-2018 TOPB45_0774 ae2309a665c35a0c1f15d46a6aa6c278 215 TIGRFAM TIGR01351 adk: adenylate kinase 2 212 1.2E-87 T 13-10-2018 IPR006259 Adenylate kinase subfamily GO:0004017|GO:0005524|GO:0016776 KEGG: 00230+2.7.4.3|KEGG: 00730+2.7.4.3|MetaCyc: PWY-7219 TOPB45_0774 ae2309a665c35a0c1f15d46a6aa6c278 215 PRINTS PR00094 Adenylate kinase signature 177 191 1.0E-38 T 13-10-2018 IPR000850 Adenylate kinase/UMP-CMP kinase GO:0005524|GO:0006139|GO:0019205 KEGG: 00230+2.7.4.3|KEGG: 00730+2.7.4.3|MetaCyc: PWY-7219|Reactome: R-HSA-499943 TOPB45_0774 ae2309a665c35a0c1f15d46a6aa6c278 215 PRINTS PR00094 Adenylate kinase signature 4 17 1.0E-38 T 13-10-2018 IPR000850 Adenylate kinase/UMP-CMP kinase GO:0005524|GO:0006139|GO:0019205 KEGG: 00230+2.7.4.3|KEGG: 00730+2.7.4.3|MetaCyc: PWY-7219|Reactome: R-HSA-499943 TOPB45_0774 ae2309a665c35a0c1f15d46a6aa6c278 215 PRINTS PR00094 Adenylate kinase signature 32 46 1.0E-38 T 13-10-2018 IPR000850 Adenylate kinase/UMP-CMP kinase GO:0005524|GO:0006139|GO:0019205 KEGG: 00230+2.7.4.3|KEGG: 00730+2.7.4.3|MetaCyc: PWY-7219|Reactome: R-HSA-499943 TOPB45_0774 ae2309a665c35a0c1f15d46a6aa6c278 215 PRINTS PR00094 Adenylate kinase signature 160 175 1.0E-38 T 13-10-2018 IPR000850 Adenylate kinase/UMP-CMP kinase GO:0005524|GO:0006139|GO:0019205 KEGG: 00230+2.7.4.3|KEGG: 00730+2.7.4.3|MetaCyc: PWY-7219|Reactome: R-HSA-499943 TOPB45_0774 ae2309a665c35a0c1f15d46a6aa6c278 215 PRINTS PR00094 Adenylate kinase signature 81 97 1.0E-38 T 13-10-2018 IPR000850 Adenylate kinase/UMP-CMP kinase GO:0005524|GO:0006139|GO:0019205 KEGG: 00230+2.7.4.3|KEGG: 00730+2.7.4.3|MetaCyc: PWY-7219|Reactome: R-HSA-499943 TOPB45_0774 ae2309a665c35a0c1f15d46a6aa6c278 215 Gene3D G3DSA:3.40.50.300 1 215 7.3E-92 T 13-10-2018 TOPB45_0774 ae2309a665c35a0c1f15d46a6aa6c278 215 Hamap MF_00235 Adenylate kinase [adk]. 1 213 56.304 T 13-10-2018 IPR000850 Adenylate kinase/UMP-CMP kinase GO:0005524|GO:0006139|GO:0019205 KEGG: 00230+2.7.4.3|KEGG: 00730+2.7.4.3|MetaCyc: PWY-7219|Reactome: R-HSA-499943 TOPB45_0774 ae2309a665c35a0c1f15d46a6aa6c278 215 Pfam PF05191 Adenylate kinase, active site lid 127 162 3.3E-19 T 13-10-2018 IPR007862 Adenylate kinase, active site lid domain GO:0004017 KEGG: 00230+2.7.4.3|KEGG: 00730+2.7.4.3|MetaCyc: PWY-7219 TOPB45_0774 ae2309a665c35a0c1f15d46a6aa6c278 215 SUPERFAMILY SSF52540 1 215 3.13E-52 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0192 3a537a7bcf995a96ef83524bcd12bd0d 441 PRINTS PR00149 Fumarate lyase superfamily signature 97 115 1.5E-27 T 13-10-2018 IPR000362 Fumarate lyase family TOPB45_0192 3a537a7bcf995a96ef83524bcd12bd0d 441 PRINTS PR00149 Fumarate lyase superfamily signature 225 252 1.5E-27 T 13-10-2018 IPR000362 Fumarate lyase family TOPB45_0192 3a537a7bcf995a96ef83524bcd12bd0d 441 PRINTS PR00149 Fumarate lyase superfamily signature 270 286 1.5E-27 T 13-10-2018 IPR000362 Fumarate lyase family TOPB45_0192 3a537a7bcf995a96ef83524bcd12bd0d 441 PRINTS PR00149 Fumarate lyase superfamily signature 142 160 1.5E-27 T 13-10-2018 IPR000362 Fumarate lyase family TOPB45_0192 3a537a7bcf995a96ef83524bcd12bd0d 441 Pfam PF10397 Adenylosuccinate lyase C-terminus 359 438 7.2E-27 T 13-10-2018 IPR019468 Adenylosuccinate lyase C-terminal KEGG: 00230+4.3.2.2|KEGG: 00250+4.3.2.2|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7219|MetaCyc: PWY-7234|Reactome: R-HSA-73817 TOPB45_0192 3a537a7bcf995a96ef83524bcd12bd0d 441 SMART SM00998 358 439 3.3E-37 T 13-10-2018 IPR019468 Adenylosuccinate lyase C-terminal KEGG: 00230+4.3.2.2|KEGG: 00250+4.3.2.2|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7219|MetaCyc: PWY-7234|Reactome: R-HSA-73817 TOPB45_0192 3a537a7bcf995a96ef83524bcd12bd0d 441 Gene3D G3DSA:1.20.200.10 102 356 6.5E-97 T 13-10-2018 TOPB45_0192 3a537a7bcf995a96ef83524bcd12bd0d 441 PRINTS PR00145 Argininosuccinate lyase family signature 137 157 1.1E-10 T 13-10-2018 TOPB45_0192 3a537a7bcf995a96ef83524bcd12bd0d 441 PRINTS PR00145 Argininosuccinate lyase family signature 225 249 1.1E-10 T 13-10-2018 TOPB45_0192 3a537a7bcf995a96ef83524bcd12bd0d 441 PRINTS PR00145 Argininosuccinate lyase family signature 270 286 1.1E-10 T 13-10-2018 TOPB45_0192 3a537a7bcf995a96ef83524bcd12bd0d 441 PRINTS PR00145 Argininosuccinate lyase family signature 96 118 1.1E-10 T 13-10-2018 TOPB45_0192 3a537a7bcf995a96ef83524bcd12bd0d 441 TIGRFAM TIGR00928 purB: adenylosuccinate lyase 1 439 3.7E-169 T 13-10-2018 IPR004769 Adenylosuccinate lyase GO:0004018|GO:0009152 KEGG: 00230+4.3.2.2|KEGG: 00250+4.3.2.2|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7219|MetaCyc: PWY-7234|Reactome: R-HSA-73817 TOPB45_0192 3a537a7bcf995a96ef83524bcd12bd0d 441 Gene3D G3DSA:1.10.275.10 1 101 2.1E-28 T 13-10-2018 IPR024083 Fumarase/histidase, N-terminal TOPB45_0192 3a537a7bcf995a96ef83524bcd12bd0d 441 ProSitePatterns PS00163 Fumarate lyases signature. 270 279 - T 13-10-2018 IPR020557 Fumarate lyase, conserved site GO:0003824 TOPB45_0192 3a537a7bcf995a96ef83524bcd12bd0d 441 Gene3D G3DSA:1.10.40.30 358 438 1.9E-32 T 13-10-2018 TOPB45_0192 3a537a7bcf995a96ef83524bcd12bd0d 441 Pfam PF00206 Lyase 26 291 3.3E-57 T 13-10-2018 IPR022761 Fumarate lyase, N-terminal TOPB45_0192 3a537a7bcf995a96ef83524bcd12bd0d 441 SUPERFAMILY SSF48557 3 439 2.2E-132 T 13-10-2018 IPR008948 L-Aspartase-like GO:0003824 TOPB45_1299 cdfa12f74641837c603b58821e486d1f 420 Gene3D G3DSA:3.40.47.10 1 258 1.7E-64 T 13-10-2018 IPR016039 Thiolase-like GO:0003824 TOPB45_1299 cdfa12f74641837c603b58821e486d1f 420 SUPERFAMILY SSF53901 4 254 2.54E-54 T 13-10-2018 IPR016039 Thiolase-like GO:0003824 TOPB45_1299 cdfa12f74641837c603b58821e486d1f 420 SMART SM00825 Beta-ketoacyl synthase 6 417 5.7E-13 T 13-10-2018 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain TOPB45_1299 cdfa12f74641837c603b58821e486d1f 420 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 4 250 2.2E-33 T 13-10-2018 IPR014030 Beta-ketoacyl synthase, N-terminal TOPB45_1299 cdfa12f74641837c603b58821e486d1f 420 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 258 372 7.4E-36 T 13-10-2018 IPR014031 Beta-ketoacyl synthase, C-terminal TOPB45_1299 cdfa12f74641837c603b58821e486d1f 420 SUPERFAMILY SSF53901 219 415 4.4E-65 T 13-10-2018 IPR016039 Thiolase-like GO:0003824 TOPB45_1299 cdfa12f74641837c603b58821e486d1f 420 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 156 172 - T 13-10-2018 IPR018201 Beta-ketoacyl synthase, active site TOPB45_1299 cdfa12f74641837c603b58821e486d1f 420 Gene3D G3DSA:3.40.47.10 260 404 7.5E-52 T 13-10-2018 IPR016039 Thiolase-like GO:0003824 TOPB45_0246 27f2c1cae295d5fecc3fac42d4be8633 465 SUPERFAMILY SSF51735 167 321 8.55E-40 T 13-10-2018 IPR036291 NAD(P)-binding domain superfamily TOPB45_0246 27f2c1cae295d5fecc3fac42d4be8633 465 Gene3D G3DSA:3.30.460.30 6 164 5.8E-52 T 13-10-2018 IPR036343 Glutamyl-tRNA reductase, N-terminal domain superfamily GO:0008883|GO:0033014|GO:0050661|GO:0055114 KEGG: 00860+1.2.1.70|MetaCyc: PWY-5188 TOPB45_0246 27f2c1cae295d5fecc3fac42d4be8633 465 Pfam PF01488 Shikimate / quinate 5-dehydrogenase 178 312 5.7E-50 T 13-10-2018 IPR006151 Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase TOPB45_0246 27f2c1cae295d5fecc3fac42d4be8633 465 Gene3D G3DSA:3.40.50.720 167 319 1.7E-50 T 13-10-2018 TOPB45_0246 27f2c1cae295d5fecc3fac42d4be8633 465 ProSitePatterns PS00747 Glutamyl-tRNA reductase signature. 105 128 - T 13-10-2018 IPR018214 Glutamyl-tRNA reductase, conserved site GO:0008883|GO:0055114 KEGG: 00860+1.2.1.70|MetaCyc: PWY-5188 TOPB45_0246 27f2c1cae295d5fecc3fac42d4be8633 465 SUPERFAMILY SSF69742 6 164 4.45E-45 T 13-10-2018 IPR036343 Glutamyl-tRNA reductase, N-terminal domain superfamily GO:0008883|GO:0033014|GO:0050661|GO:0055114 KEGG: 00860+1.2.1.70|MetaCyc: PWY-5188 TOPB45_0246 27f2c1cae295d5fecc3fac42d4be8633 465 Pfam PF00745 Glutamyl-tRNAGlu reductase, dimerisation domain 326 424 2.1E-22 T 13-10-2018 IPR015896 Tetrapyrrole biosynthesis, glutamyl-tRNA reductase, dimerisation domain GO:0008883|GO:0033014|GO:0050661|GO:0055114 KEGG: 00860+1.2.1.70|MetaCyc: PWY-5188 TOPB45_0246 27f2c1cae295d5fecc3fac42d4be8633 465 SUPERFAMILY SSF69075 323 425 1.44E-21 T 13-10-2018 IPR036453 Glutamyl tRNA-reductase dimerization domain superfamily GO:0008883|GO:0033014|GO:0050661|GO:0055114 KEGG: 00860+1.2.1.70|MetaCyc: PWY-5188 TOPB45_0246 27f2c1cae295d5fecc3fac42d4be8633 465 TIGRFAM TIGR01035 hemA: glutamyl-tRNA reductase 7 425 6.8E-145 T 13-10-2018 IPR000343 Tetrapyrrole biosynthesis, glutamyl-tRNA reductase GO:0008883|GO:0033014|GO:0050661|GO:0055114 KEGG: 00860+1.2.1.70|MetaCyc: PWY-5188 TOPB45_0246 27f2c1cae295d5fecc3fac42d4be8633 465 Hamap MF_00087 Glutamyl-tRNA reductase [hemA]. 6 425 30.221 T 13-10-2018 IPR000343 Tetrapyrrole biosynthesis, glutamyl-tRNA reductase GO:0008883|GO:0033014|GO:0050661|GO:0055114 KEGG: 00860+1.2.1.70|MetaCyc: PWY-5188 TOPB45_0246 27f2c1cae295d5fecc3fac42d4be8633 465 PIRSF PIRSF000445 5 438 1.5E-154 T 13-10-2018 IPR000343 Tetrapyrrole biosynthesis, glutamyl-tRNA reductase GO:0008883|GO:0033014|GO:0050661|GO:0055114 KEGG: 00860+1.2.1.70|MetaCyc: PWY-5188 TOPB45_0246 27f2c1cae295d5fecc3fac42d4be8633 465 Pfam PF05201 Glutamyl-tRNAGlu reductase, N-terminal domain 10 162 1.1E-45 T 13-10-2018 IPR015895 Tetrapyrrole biosynthesis, glutamyl-tRNA reductase, N-terminal GO:0008883|GO:0033014|GO:0050661|GO:0055114 KEGG: 00860+1.2.1.70|MetaCyc: PWY-5188 TOPB45_1522 9b45195b76b65c9aa3d16981af3bd6ac 133 SUPERFAMILY SSF47240 1 133 7.03E-18 T 13-10-2018 IPR009078 Ferritin-like superfamily TOPB45_1522 9b45195b76b65c9aa3d16981af3bd6ac 133 Gene3D G3DSA:1.20.1260.10 4 133 2.1E-19 T 13-10-2018 IPR012347 Ferritin-like TOPB45_1522 9b45195b76b65c9aa3d16981af3bd6ac 133 Pfam PF02915 Rubrerythrin 19 84 6.2E-7 T 13-10-2018 IPR003251 Rubrerythrin GO:0016491|GO:0046872|GO:0055114 TOPB45_0724 40a5fa66efe3a70418ce0c6056c38c08 413 TIGRFAM TIGR00656 asp_kin_monofn: aspartate kinase, monofunctional class 1 400 3.6E-139 T 13-10-2018 IPR005260 Aspartate kinase, monofunctional class GO:0004072|GO:0009089 KEGG: 00260+2.7.2.4|KEGG: 00261+2.7.2.4|KEGG: 00270+2.7.2.4|KEGG: 00300+2.7.2.4|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|MetaCyc: PWY-6160|MetaCyc: PWY-6559|MetaCyc: PWY-6562|MetaCyc: PWY-7153|MetaCyc: PWY-7977 TOPB45_0724 40a5fa66efe3a70418ce0c6056c38c08 413 PIRSF PIRSF000726 1 63 9.1E-22 T 13-10-2018 IPR005260 Aspartate kinase, monofunctional class GO:0004072|GO:0009089 KEGG: 00260+2.7.2.4|KEGG: 00261+2.7.2.4|KEGG: 00270+2.7.2.4|KEGG: 00300+2.7.2.4|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|MetaCyc: PWY-6160|MetaCyc: PWY-6559|MetaCyc: PWY-6562|MetaCyc: PWY-7153|MetaCyc: PWY-7977 TOPB45_0724 40a5fa66efe3a70418ce0c6056c38c08 413 PIRSF PIRSF000726 57 406 2.2E-137 T 13-10-2018 IPR005260 Aspartate kinase, monofunctional class GO:0004072|GO:0009089 KEGG: 00260+2.7.2.4|KEGG: 00261+2.7.2.4|KEGG: 00270+2.7.2.4|KEGG: 00300+2.7.2.4|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|MetaCyc: PWY-6160|MetaCyc: PWY-6559|MetaCyc: PWY-6562|MetaCyc: PWY-7153|MetaCyc: PWY-7977 TOPB45_0724 40a5fa66efe3a70418ce0c6056c38c08 413 SUPERFAMILY SSF55021 246 325 6.47E-20 T 13-10-2018 TOPB45_0724 40a5fa66efe3a70418ce0c6056c38c08 413 ProSitePatterns PS00324 Aspartokinase signature. 4 12 - T 13-10-2018 IPR018042 Aspartate kinase, conserved site GO:0004072|GO:0008652 KEGG: 00260+2.7.2.4|KEGG: 00261+2.7.2.4|KEGG: 00270+2.7.2.4|KEGG: 00300+2.7.2.4|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|MetaCyc: PWY-6160|MetaCyc: PWY-6559|MetaCyc: PWY-6562|MetaCyc: PWY-7153|MetaCyc: PWY-7977 TOPB45_0724 40a5fa66efe3a70418ce0c6056c38c08 413 Pfam PF01842 ACT domain 263 324 6.9E-15 T 13-10-2018 IPR002912 ACT domain TOPB45_0724 40a5fa66efe3a70418ce0c6056c38c08 413 Pfam PF00696 Amino acid kinase family 1 229 1.2E-54 T 13-10-2018 IPR001048 Aspartate/glutamate/uridylate kinase Reactome: R-HSA-70614 TOPB45_0724 40a5fa66efe3a70418ce0c6056c38c08 413 Gene3D G3DSA:3.40.1160.10 1 252 5.9E-90 T 13-10-2018 IPR036393 Acetylglutamate kinase-like superfamily TOPB45_0724 40a5fa66efe3a70418ce0c6056c38c08 413 Pfam PF13840 ACT domain 335 397 4.8E-17 T 13-10-2018 IPR027795 CASTOR, ACT domain TOPB45_0724 40a5fa66efe3a70418ce0c6056c38c08 413 Gene3D G3DSA:3.30.70.260 259 336 3.5E-63 T 13-10-2018 TOPB45_0724 40a5fa66efe3a70418ce0c6056c38c08 413 TIGRFAM TIGR00657 asp_kinases: aspartate kinase 63 400 8.6E-127 T 13-10-2018 IPR001341 Aspartate kinase GO:0004072|GO:0008652 KEGG: 00260+2.7.2.4|KEGG: 00261+2.7.2.4|KEGG: 00270+2.7.2.4|KEGG: 00300+2.7.2.4|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|MetaCyc: PWY-6160|MetaCyc: PWY-6559|MetaCyc: PWY-6562|MetaCyc: PWY-7153|MetaCyc: PWY-7977 TOPB45_0724 40a5fa66efe3a70418ce0c6056c38c08 413 SUPERFAMILY SSF55021 327 402 3.6E-26 T 13-10-2018 TOPB45_0724 40a5fa66efe3a70418ce0c6056c38c08 413 SUPERFAMILY SSF53633 3 242 2.23E-76 T 13-10-2018 IPR036393 Acetylglutamate kinase-like superfamily TOPB45_0724 40a5fa66efe3a70418ce0c6056c38c08 413 Gene3D G3DSA:3.30.70.260 253 401 3.5E-63 T 13-10-2018 TOPB45_0466 b63ca6147cec1048d452765fd2a654a3 183 Gene3D G3DSA:3.40.50.1450 25 183 7.8E-47 T 13-10-2018 IPR023430 Peptidase HybD-like domain superfamily TOPB45_0466 b63ca6147cec1048d452765fd2a654a3 183 Pfam PF01750 Hydrogenase maturation protease 44 170 6.6E-37 T 13-10-2018 IPR000671 Peptidase A31 family GO:0008047|GO:0008233 TOPB45_0466 b63ca6147cec1048d452765fd2a654a3 183 PRINTS PR00446 Hydrogen uptake protein signature 80 90 1.1E-23 T 13-10-2018 IPR000671 Peptidase A31 family GO:0008047|GO:0008233 TOPB45_0466 b63ca6147cec1048d452765fd2a654a3 183 PRINTS PR00446 Hydrogen uptake protein signature 27 39 1.1E-23 T 13-10-2018 IPR000671 Peptidase A31 family GO:0008047|GO:0008233 TOPB45_0466 b63ca6147cec1048d452765fd2a654a3 183 PRINTS PR00446 Hydrogen uptake protein signature 59 76 1.1E-23 T 13-10-2018 IPR000671 Peptidase A31 family GO:0008047|GO:0008233 TOPB45_0466 b63ca6147cec1048d452765fd2a654a3 183 PRINTS PR00446 Hydrogen uptake protein signature 91 107 1.1E-23 T 13-10-2018 IPR000671 Peptidase A31 family GO:0008047|GO:0008233 TOPB45_0466 b63ca6147cec1048d452765fd2a654a3 183 PRINTS PR00446 Hydrogen uptake protein signature 39 50 1.1E-23 T 13-10-2018 IPR000671 Peptidase A31 family GO:0008047|GO:0008233 TOPB45_0466 b63ca6147cec1048d452765fd2a654a3 183 TIGRFAM TIGR00140 hupD: hydrogenase expression/formation protein 27 176 5.0E-49 T 13-10-2018 IPR004419 Peptidase A31, hydrogenase expression/formation protein GO:0016485|GO:0046872 TOPB45_0466 b63ca6147cec1048d452765fd2a654a3 183 TIGRFAM TIGR00072 hydrog_prot: hydrogenase maturation protease 28 172 2.7E-45 T 13-10-2018 IPR000671 Peptidase A31 family GO:0008047|GO:0008233 TOPB45_0466 b63ca6147cec1048d452765fd2a654a3 183 SUPERFAMILY SSF53163 26 180 1.99E-45 T 13-10-2018 IPR023430 Peptidase HybD-like domain superfamily TOPB45_0341 b7fb1d6426fecf0c02addcfea9f2a0c4 294 SUPERFAMILY SSF53448 7 274 2.19E-41 T 13-10-2018 IPR029044 Nucleotide-diphospho-sugar transferases TOPB45_0341 b7fb1d6426fecf0c02addcfea9f2a0c4 294 TIGRFAM TIGR01556 rhamnosyltran: rhamnosyltransferase 9 282 2.1E-60 T 13-10-2018 IPR006446 Rhamnosyltransferase TOPB45_0341 b7fb1d6426fecf0c02addcfea9f2a0c4 294 Pfam PF00535 Glycosyl transferase family 2 7 163 1.5E-17 T 13-10-2018 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 TOPB45_0341 b7fb1d6426fecf0c02addcfea9f2a0c4 294 Gene3D G3DSA:3.90.550.10 2 212 2.2E-33 T 13-10-2018 IPR029044 Nucleotide-diphospho-sugar transferases TOPB45_0174 1db81b19860e91a94e935b85d51dbea3 735 Pfam PF13187 4Fe-4S dicluster domain 529 574 5.4E-8 T 13-10-2018 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain TOPB45_0174 1db81b19860e91a94e935b85d51dbea3 735 Gene3D G3DSA:3.50.50.60 150 289 1.0E-18 T 13-10-2018 IPR036188 FAD/NAD(P)-binding domain superfamily TOPB45_0174 1db81b19860e91a94e935b85d51dbea3 735 Gene3D G3DSA:3.30.70.20 518 582 1.1E-10 T 13-10-2018 TOPB45_0174 1db81b19860e91a94e935b85d51dbea3 735 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 155 177 4.7E-9 T 13-10-2018 TOPB45_0174 1db81b19860e91a94e935b85d51dbea3 735 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 417 431 4.7E-9 T 13-10-2018 TOPB45_0174 1db81b19860e91a94e935b85d51dbea3 735 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 473 480 4.7E-9 T 13-10-2018 TOPB45_0174 1db81b19860e91a94e935b85d51dbea3 735 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 559 570 - T 13-10-2018 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site TOPB45_0174 1db81b19860e91a94e935b85d51dbea3 735 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 156 175 1.4E-6 T 13-10-2018 TOPB45_0174 1db81b19860e91a94e935b85d51dbea3 735 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 416 432 1.4E-6 T 13-10-2018 TOPB45_0174 1db81b19860e91a94e935b85d51dbea3 735 Gene3D G3DSA:3.50.50.60 356 424 1.2E-7 T 13-10-2018 IPR036188 FAD/NAD(P)-binding domain superfamily TOPB45_0174 1db81b19860e91a94e935b85d51dbea3 735 SUPERFAMILY SSF51971 154 503 2.12E-30 T 13-10-2018 TOPB45_0174 1db81b19860e91a94e935b85d51dbea3 735 Gene3D G3DSA:3.50.50.60 425 499 1.2E-7 T 13-10-2018 IPR036188 FAD/NAD(P)-binding domain superfamily TOPB45_0174 1db81b19860e91a94e935b85d51dbea3 735 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 155 491 2.0E-19 T 13-10-2018 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TOPB45_0174 1db81b19860e91a94e935b85d51dbea3 735 SUPERFAMILY SSF54862 521 595 1.0E-14 T 13-10-2018 TOPB45_0174 1db81b19860e91a94e935b85d51dbea3 735 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 529 540 - T 13-10-2018 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site TOPB45_0174 1db81b19860e91a94e935b85d51dbea3 735 Pfam PF02662 Methyl-viologen-reducing hydrogenase, delta subunit 604 725 1.4E-38 T 13-10-2018 IPR003813 F420-non-reducing hydrogenase iron-sulfur subunit D GO:0055114 TOPB45_1255 d3f1a07dd46be99fd5fe5aca30475656 1466 Pfam PF04898 Glutamate synthase central domain 448 725 7.6E-104 T 13-10-2018 IPR006982 Glutamate synthase, central-N GO:0006807|GO:0015930|GO:0055114 TOPB45_1255 d3f1a07dd46be99fd5fe5aca30475656 1466 SUPERFAMILY SSF56235 9 423 2.47E-135 T 13-10-2018 IPR029055 Nucleophile aminohydrolases, N-terminal TOPB45_1255 d3f1a07dd46be99fd5fe5aca30475656 1466 SUPERFAMILY SSF51395 441 1163 6.41E-239 T 13-10-2018 TOPB45_1255 d3f1a07dd46be99fd5fe5aca30475656 1466 Gene3D G3DSA:3.60.20.10 9 536 0.0 T 13-10-2018 IPR029055 Nucleophile aminohydrolases, N-terminal TOPB45_1255 d3f1a07dd46be99fd5fe5aca30475656 1466 Pfam PF01645 Conserved region in glutamate synthase 784 1144 6.1E-150 T 13-10-2018 IPR002932 Glutamate synthase domain GO:0006537|GO:0015930|GO:0016638|GO:0055114 TOPB45_1255 d3f1a07dd46be99fd5fe5aca30475656 1466 Pfam PF00310 Glutamine amidotransferases class-II 9 419 3.3E-164 T 13-10-2018 IPR017932 Glutamine amidotransferase type 2 domain TOPB45_1255 d3f1a07dd46be99fd5fe5aca30475656 1466 SUPERFAMILY SSF69336 1201 1450 3.79E-89 T 13-10-2018 IPR036485 Glutamate synthase, alpha subunit, C-terminal domain superfamily GO:0016491|GO:0055114 TOPB45_1255 d3f1a07dd46be99fd5fe5aca30475656 1466 Gene3D G3DSA:2.160.20.60 1198 1463 4.0E-98 T 13-10-2018 IPR036485 Glutamate synthase, alpha subunit, C-terminal domain superfamily GO:0016491|GO:0055114 TOPB45_1255 d3f1a07dd46be99fd5fe5aca30475656 1466 Gene3D G3DSA:3.20.20.70 474 1160 0.0 T 13-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 TOPB45_1255 d3f1a07dd46be99fd5fe5aca30475656 1466 Pfam PF01493 GXGXG motif 1224 1406 6.6E-74 T 13-10-2018 IPR002489 Glutamate synthase, alpha subunit, C-terminal GO:0016491|GO:0055114 TOPB45_1255 d3f1a07dd46be99fd5fe5aca30475656 1466 Gene3D G3DSA:3.20.20.70 424 781 0.0 T 13-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 TOPB45_0560 62507be5cc6b1e7f646de1165a3da4a6 458 Gene3D G3DSA:3.60.20.10 2 445 8.0E-159 T 13-10-2018 IPR029055 Nucleophile aminohydrolases, N-terminal TOPB45_0560 62507be5cc6b1e7f646de1165a3da4a6 458 SUPERFAMILY SSF53271 237 447 5.64E-62 T 13-10-2018 IPR029057 Phosphoribosyltransferase-like TOPB45_0560 62507be5cc6b1e7f646de1165a3da4a6 458 PIRSF PIRSF000485 1 457 7.1E-176 T 13-10-2018 IPR005854 Amidophosphoribosyltransferase GO:0004044|GO:0009113 KEGG: 00230+2.4.2.14|KEGG: 00250+2.4.2.14|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|MetaCyc: PWY-7282|Reactome: R-HSA-73817 TOPB45_0560 62507be5cc6b1e7f646de1165a3da4a6 458 Hamap MF_01931 Amidophosphoribosyltransferase [purF]. 1 443 45.64 T 13-10-2018 IPR005854 Amidophosphoribosyltransferase GO:0004044|GO:0009113 KEGG: 00230+2.4.2.14|KEGG: 00250+2.4.2.14|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|MetaCyc: PWY-7282|Reactome: R-HSA-73817 TOPB45_0560 62507be5cc6b1e7f646de1165a3da4a6 458 TIGRFAM TIGR01134 purF: amidophosphoribosyltransferase 2 444 6.6E-160 T 13-10-2018 IPR005854 Amidophosphoribosyltransferase GO:0004044|GO:0009113 KEGG: 00230+2.4.2.14|KEGG: 00250+2.4.2.14|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|MetaCyc: PWY-7282|Reactome: R-HSA-73817 TOPB45_0560 62507be5cc6b1e7f646de1165a3da4a6 458 Gene3D G3DSA:3.40.50.2020 262 426 8.0E-159 T 13-10-2018 TOPB45_0560 62507be5cc6b1e7f646de1165a3da4a6 458 Pfam PF13537 Glutamine amidotransferase domain 83 198 1.2E-19 T 13-10-2018 IPR017932 Glutamine amidotransferase type 2 domain TOPB45_0560 62507be5cc6b1e7f646de1165a3da4a6 458 SUPERFAMILY SSF56235 2 244 4.63E-72 T 13-10-2018 IPR029055 Nucleophile aminohydrolases, N-terminal TOPB45_1236 790f16c7cee7b03aefdfb6c9ac5592bb 357 Pfam PF02894 Oxidoreductase family, C-terminal alpha/beta domain 138 239 3.6E-11 T 13-10-2018 IPR004104 Oxidoreductase, C-terminal GO:0016491|GO:0055114 TOPB45_1236 790f16c7cee7b03aefdfb6c9ac5592bb 357 SUPERFAMILY SSF51735 3 193 1.12E-37 T 13-10-2018 IPR036291 NAD(P)-binding domain superfamily TOPB45_1236 790f16c7cee7b03aefdfb6c9ac5592bb 357 Gene3D G3DSA:3.30.360.10 134 341 1.4E-87 T 13-10-2018 TOPB45_1236 790f16c7cee7b03aefdfb6c9ac5592bb 357 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 6 122 4.6E-26 T 13-10-2018 IPR000683 Oxidoreductase, N-terminal GO:0016491 TOPB45_1236 790f16c7cee7b03aefdfb6c9ac5592bb 357 Gene3D G3DSA:3.40.50.720 7 319 1.4E-87 T 13-10-2018 TOPB45_1248 9b0204ab8bf1d9ed965890e3743f3370 454 Pfam PF00158 Sigma-54 interaction domain 146 311 2.6E-71 T 13-10-2018 IPR002078 RNA polymerase sigma factor 54 interaction domain GO:0005524|GO:0006355|GO:0008134 TOPB45_1248 9b0204ab8bf1d9ed965890e3743f3370 454 SUPERFAMILY SSF46689 360 451 1.64E-16 T 13-10-2018 IPR009057 Homeobox-like domain superfamily GO:0003677 TOPB45_1248 9b0204ab8bf1d9ed965890e3743f3370 454 Pfam PF02954 Bacterial regulatory protein, Fis family 408 449 7.5E-16 T 13-10-2018 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 TOPB45_1248 9b0204ab8bf1d9ed965890e3743f3370 454 Gene3D G3DSA:1.10.8.60 319 396 3.1E-27 T 13-10-2018 TOPB45_1248 9b0204ab8bf1d9ed965890e3743f3370 454 ProSitePatterns PS00688 Sigma-54 interaction domain C-terminal part signature. 359 368 - T 13-10-2018 IPR025944 Sigma-54 interaction domain, conserved site TOPB45_1248 9b0204ab8bf1d9ed965890e3743f3370 454 Pfam PF00072 Response regulator receiver domain 7 114 4.5E-30 T 13-10-2018 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TOPB45_1248 9b0204ab8bf1d9ed965890e3743f3370 454 SUPERFAMILY SSF52540 145 389 9.02E-75 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1248 9b0204ab8bf1d9ed965890e3743f3370 454 SUPERFAMILY SSF52172 4 191 8.11E-47 T 13-10-2018 IPR011006 CheY-like superfamily TOPB45_1248 9b0204ab8bf1d9ed965890e3743f3370 454 Gene3D G3DSA:3.40.50.300 137 317 4.9E-69 T 13-10-2018 TOPB45_1248 9b0204ab8bf1d9ed965890e3743f3370 454 PRINTS PR01590 FIS bacterial regulatory protein HTH signature 432 452 1.2E-10 T 13-10-2018 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 TOPB45_1248 9b0204ab8bf1d9ed965890e3743f3370 454 PRINTS PR01590 FIS bacterial regulatory protein HTH signature 415 432 1.2E-10 T 13-10-2018 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 TOPB45_1248 9b0204ab8bf1d9ed965890e3743f3370 454 SMART SM00448 5 116 4.6E-33 T 13-10-2018 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TOPB45_1248 9b0204ab8bf1d9ed965890e3743f3370 454 ProSitePatterns PS00676 Sigma-54 interaction domain ATP-binding region B signature. 232 247 - T 13-10-2018 IPR025943 Sigma-54 interaction domain, ATP-binding site 2 TOPB45_1248 9b0204ab8bf1d9ed965890e3743f3370 454 ProSitePatterns PS00675 Sigma-54 interaction domain ATP-binding region A signature. 170 183 - T 13-10-2018 IPR025662 Sigma-54 interaction domain, ATP-binding site 1 TOPB45_1248 9b0204ab8bf1d9ed965890e3743f3370 454 Gene3D G3DSA:1.10.10.60 406 452 3.5E-18 T 13-10-2018 TOPB45_1248 9b0204ab8bf1d9ed965890e3743f3370 454 Gene3D G3DSA:3.40.50.2300 1 136 8.4E-39 T 13-10-2018 TOPB45_1248 9b0204ab8bf1d9ed965890e3743f3370 454 SMART SM00382 166 309 1.4E-10 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_1193 0d176d3e38bac3f962cba1b3f8469893 346 Pfam PF01861 Protein of unknown function DUF43 87 333 2.6E-83 T 13-10-2018 IPR002723 N(4)-bis(aminopropyl)spermidine synthase, C-terminal TOPB45_1193 0d176d3e38bac3f962cba1b3f8469893 346 Gene3D G3DSA:3.40.50.150 82 309 3.9E-75 T 13-10-2018 TOPB45_1193 0d176d3e38bac3f962cba1b3f8469893 346 SUPERFAMILY SSF53335 144 262 9.93E-11 T 13-10-2018 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TOPB45_1193 0d176d3e38bac3f962cba1b3f8469893 346 Hamap MF_01947 N(4)-bis(aminopropyl)spermidine synthase [bpsA]. 3 335 42.989 T 13-10-2018 IPR014435 N(4)-bis(aminopropyl)spermidine synthase GO:0006596|GO:0016765 TOPB45_0422 7cdcf6769981bbf6af0492c0b4243779 404 SUPERFAMILY SSF102645 187 402 7.72E-51 T 13-10-2018 IPR035929 CoaB-like superfamily KEGG: 00770+6.3.2.5|Reactome: R-HSA-196783 TOPB45_0422 7cdcf6769981bbf6af0492c0b4243779 404 Gene3D G3DSA:3.40.50.10300 189 404 4.7E-55 T 13-10-2018 IPR035929 CoaB-like superfamily KEGG: 00770+6.3.2.5|Reactome: R-HSA-196783 TOPB45_0422 7cdcf6769981bbf6af0492c0b4243779 404 Gene3D G3DSA:3.40.50.1950 4 188 1.5E-55 T 13-10-2018 IPR036551 Flavin prenyltransferase-like GO:0003824 Reactome: R-HSA-196783 TOPB45_0422 7cdcf6769981bbf6af0492c0b4243779 404 Pfam PF04127 DNA / pantothenate metabolism flavoprotein 190 370 7.1E-47 T 13-10-2018 IPR007085 DNA/pantothenate metabolism flavoprotein, C-terminal KEGG: 00770+6.3.2.5|Reactome: R-HSA-196783 TOPB45_0422 7cdcf6769981bbf6af0492c0b4243779 404 SUPERFAMILY SSF52507 6 184 2.75E-55 T 13-10-2018 IPR036551 Flavin prenyltransferase-like GO:0003824 Reactome: R-HSA-196783 TOPB45_0422 7cdcf6769981bbf6af0492c0b4243779 404 TIGRFAM TIGR00521 coaBC_dfp: phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase 7 402 1.4E-105 T 13-10-2018 IPR005252 Coenzyme A biosynthesis bifunctional protein CoaBC GO:0004632|GO:0004633|GO:0010181|GO:0015937|GO:0015941 KEGG: 00770+4.1.1.36+6.3.2.5|MetaCyc: PWY-7851 TOPB45_0422 7cdcf6769981bbf6af0492c0b4243779 404 Pfam PF02441 Flavoprotein 10 181 5.0E-42 T 13-10-2018 IPR003382 Flavoprotein GO:0003824 Reactome: R-HSA-196783 TOPB45_0748 3d329fdf098b9d5567fe0216f3afc4ce 123 Gene3D G3DSA:2.40.50.140 1 123 2.8E-64 T 13-10-2018 TOPB45_0748 3d329fdf098b9d5567fe0216f3afc4ce 123 TIGRFAM TIGR00981 rpsL_bact: ribosomal protein uS12 1 123 1.4E-67 T 13-10-2018 IPR005679 Ribosomal protein S12, bacterial-type GO:0003735|GO:0006412|GO:0015935 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0748 3d329fdf098b9d5567fe0216f3afc4ce 123 PIRSF PIRSF002133 1 123 4.1E-56 T 13-10-2018 IPR006032 Ribosomal protein S12/S23 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0748 3d329fdf098b9d5567fe0216f3afc4ce 123 PRINTS PR01034 Ribosomal protein S12 signature 42 57 4.0E-59 T 13-10-2018 IPR006032 Ribosomal protein S12/S23 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0748 3d329fdf098b9d5567fe0216f3afc4ce 123 PRINTS PR01034 Ribosomal protein S12 signature 58 77 4.0E-59 T 13-10-2018 IPR006032 Ribosomal protein S12/S23 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0748 3d329fdf098b9d5567fe0216f3afc4ce 123 PRINTS PR01034 Ribosomal protein S12 signature 27 42 4.0E-59 T 13-10-2018 IPR006032 Ribosomal protein S12/S23 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0748 3d329fdf098b9d5567fe0216f3afc4ce 123 PRINTS PR01034 Ribosomal protein S12 signature 77 94 4.0E-59 T 13-10-2018 IPR006032 Ribosomal protein S12/S23 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0748 3d329fdf098b9d5567fe0216f3afc4ce 123 PRINTS PR01034 Ribosomal protein S12 signature 94 110 4.0E-59 T 13-10-2018 IPR006032 Ribosomal protein S12/S23 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0748 3d329fdf098b9d5567fe0216f3afc4ce 123 PRINTS PR01034 Ribosomal protein S12 signature 110 122 4.0E-59 T 13-10-2018 IPR006032 Ribosomal protein S12/S23 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0748 3d329fdf098b9d5567fe0216f3afc4ce 123 ProSitePatterns PS00055 Ribosomal protein S12 signature. 43 50 - T 13-10-2018 IPR006032 Ribosomal protein S12/S23 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0748 3d329fdf098b9d5567fe0216f3afc4ce 123 Hamap MF_00403_B 30S ribosomal protein S12 [rpsL]. 1 123 40.507 T 13-10-2018 IPR005679 Ribosomal protein S12, bacterial-type GO:0003735|GO:0006412|GO:0015935 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0748 3d329fdf098b9d5567fe0216f3afc4ce 123 SUPERFAMILY SSF50249 2 123 2.4E-53 T 13-10-2018 IPR012340 Nucleic acid-binding, OB-fold TOPB45_0748 3d329fdf098b9d5567fe0216f3afc4ce 123 Pfam PF00164 Ribosomal protein S12/S23 14 123 2.0E-42 T 13-10-2018 IPR006032 Ribosomal protein S12/S23 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_1484 015af2a79a88de689e846949dd6da9ca 462 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 7 26 3.8E-5 T 13-10-2018 TOPB45_1484 015af2a79a88de689e846949dd6da9ca 462 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 412 434 3.8E-5 T 13-10-2018 TOPB45_1484 015af2a79a88de689e846949dd6da9ca 462 SUPERFAMILY SSF51905 2 456 7.35E-30 T 13-10-2018 IPR036188 FAD/NAD(P)-binding domain superfamily TOPB45_1484 015af2a79a88de689e846949dd6da9ca 462 Pfam PF03486 HI0933-like protein 5 42 8.2E-7 T 13-10-2018 TOPB45_1484 015af2a79a88de689e846949dd6da9ca 462 Gene3D G3DSA:3.50.50.60 2 123 2.5E-24 T 13-10-2018 IPR036188 FAD/NAD(P)-binding domain superfamily TOPB45_1484 015af2a79a88de689e846949dd6da9ca 462 Gene3D G3DSA:3.50.50.60 127 234 2.5E-11 T 13-10-2018 IPR036188 FAD/NAD(P)-binding domain superfamily TOPB45_1484 015af2a79a88de689e846949dd6da9ca 462 PIRSF PIRSF038984 1 460 3.8E-43 T 13-10-2018 IPR028348 FAD dependent protein TOPB45_0599 430169a3b5c06fd2e252f80346dddabc 348 SUPERFAMILY SSF53756 10 339 1.28E-58 T 13-10-2018 TOPB45_0599 430169a3b5c06fd2e252f80346dddabc 348 Pfam PF00534 Glycosyl transferases group 1 168 304 2.4E-24 T 13-10-2018 IPR001296 Glycosyl transferase, family 1 TOPB45_0599 430169a3b5c06fd2e252f80346dddabc 348 Gene3D G3DSA:3.40.50.2000 12 338 3.7E-84 T 13-10-2018 TOPB45_0599 430169a3b5c06fd2e252f80346dddabc 348 Pfam PF13439 Glycosyltransferase Family 4 18 128 2.3E-12 T 13-10-2018 IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain Reactome: R-HSA-446193|Reactome: R-HSA-4549349 TOPB45_0599 430169a3b5c06fd2e252f80346dddabc 348 Gene3D G3DSA:3.40.50.2000 157 332 3.7E-84 T 13-10-2018 TOPB45_1583 1dacce6530713b1806912f0755378bb1 365 TIGRFAM TIGR00033 aroC: chorismate synthase 10 349 2.2E-137 T 13-10-2018 IPR000453 Chorismate synthase GO:0004107|GO:0009073 KEGG: 00400+4.2.3.5|MetaCyc: PWY-6163 TOPB45_1583 1dacce6530713b1806912f0755378bb1 365 PIRSF PIRSF001456 3 359 4.8E-149 T 13-10-2018 IPR000453 Chorismate synthase GO:0004107|GO:0009073 KEGG: 00400+4.2.3.5|MetaCyc: PWY-6163 TOPB45_1583 1dacce6530713b1806912f0755378bb1 365 SUPERFAMILY SSF103263 4 350 1.31E-141 T 13-10-2018 IPR035904 Chorismate synthase AroC superfamily KEGG: 00400+4.2.3.5|MetaCyc: PWY-6163 TOPB45_1583 1dacce6530713b1806912f0755378bb1 365 Hamap MF_00300 Chorismate synthase [aroC]. 10 352 38.88 T 13-10-2018 IPR000453 Chorismate synthase GO:0004107|GO:0009073 KEGG: 00400+4.2.3.5|MetaCyc: PWY-6163 TOPB45_1583 1dacce6530713b1806912f0755378bb1 365 ProSitePatterns PS00788 Chorismate synthase signature 2. 125 141 - T 13-10-2018 IPR020541 Chorismate synthase, conserved site GO:0004107|GO:0009073 KEGG: 00400+4.2.3.5|MetaCyc: PWY-6163 TOPB45_1583 1dacce6530713b1806912f0755378bb1 365 Pfam PF01264 Chorismate synthase 10 345 2.5E-142 T 13-10-2018 IPR000453 Chorismate synthase GO:0004107|GO:0009073 KEGG: 00400+4.2.3.5|MetaCyc: PWY-6163 TOPB45_1583 1dacce6530713b1806912f0755378bb1 365 Gene3D G3DSA:3.60.150.10 1 359 4.4E-155 T 13-10-2018 IPR035904 Chorismate synthase AroC superfamily KEGG: 00400+4.2.3.5|MetaCyc: PWY-6163 TOPB45_1583 1dacce6530713b1806912f0755378bb1 365 ProSitePatterns PS00787 Chorismate synthase signature 1. 16 31 - T 13-10-2018 IPR020541 Chorismate synthase, conserved site GO:0004107|GO:0009073 KEGG: 00400+4.2.3.5|MetaCyc: PWY-6163 TOPB45_1574 93f6b0016981c6ab2d1e8c7d19d541ea 231 SMART SM00382 36 230 6.5E-10 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_1574 93f6b0016981c6ab2d1e8c7d19d541ea 231 ProSitePatterns PS00211 ABC transporters family signature. 148 162 - T 13-10-2018 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TOPB45_1574 93f6b0016981c6ab2d1e8c7d19d541ea 231 Pfam PF00005 ABC transporter 27 175 4.5E-32 T 13-10-2018 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TOPB45_1574 93f6b0016981c6ab2d1e8c7d19d541ea 231 SUPERFAMILY SSF52540 7 229 3.55E-65 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1574 93f6b0016981c6ab2d1e8c7d19d541ea 231 Gene3D G3DSA:3.40.50.300 5 231 2.6E-62 T 13-10-2018 TOPB45_0443 6f9f2283a6783434bd761e5bb9981448 146 SUPERFAMILY SSF54637 10 133 5.98E-22 T 13-10-2018 IPR029069 HotDog domain superfamily TOPB45_0443 6f9f2283a6783434bd761e5bb9981448 146 TIGRFAM TIGR00369 unchar_dom_1: uncharacterized domain 1 22 135 1.2E-18 T 13-10-2018 IPR003736 Phenylacetic acid degradation-related domain Reactome: R-HSA-77289 TOPB45_0443 6f9f2283a6783434bd761e5bb9981448 146 Pfam PF03061 Thioesterase superfamily 57 124 7.5E-8 T 13-10-2018 IPR006683 Thioesterase domain Reactome: R-HSA-77289 TOPB45_0443 6f9f2283a6783434bd761e5bb9981448 146 Gene3D G3DSA:3.10.129.10 5 145 3.7E-40 T 13-10-2018 TOPB45_1486 f768a9dae9d04b9c5a1efbf4b5b522b8 817 Pfam PF01751 Toprim domain 433 534 2.9E-19 T 13-10-2018 IPR006171 TOPRIM domain TOPB45_1486 f768a9dae9d04b9c5a1efbf4b5b522b8 817 Hamap MF_01898 DNA gyrase subunit B [gyrB]. 18 817 90.4 T 13-10-2018 IPR011557 DNA gyrase, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0005694|GO:0006265 TOPB45_1486 f768a9dae9d04b9c5a1efbf4b5b522b8 817 SUPERFAMILY SSF54211 235 405 4.55E-57 T 13-10-2018 IPR020568 Ribosomal protein S5 domain 2-type fold TOPB45_1486 f768a9dae9d04b9c5a1efbf4b5b522b8 817 Gene3D G3DSA:3.30.230.10 235 406 1.4E-70 T 13-10-2018 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup TOPB45_1486 f768a9dae9d04b9c5a1efbf4b5b522b8 817 PRINTS PR00418 DNA topoisomerase II family signature 50 65 3.8E-70 T 13-10-2018 TOPB45_1486 f768a9dae9d04b9c5a1efbf4b5b522b8 817 PRINTS PR00418 DNA topoisomerase II family signature 519 536 3.8E-70 T 13-10-2018 TOPB45_1486 f768a9dae9d04b9c5a1efbf4b5b522b8 817 PRINTS PR00418 DNA topoisomerase II family signature 539 551 3.8E-70 T 13-10-2018 TOPB45_1486 f768a9dae9d04b9c5a1efbf4b5b522b8 817 PRINTS PR00418 DNA topoisomerase II family signature 749 765 3.8E-70 T 13-10-2018 TOPB45_1486 f768a9dae9d04b9c5a1efbf4b5b522b8 817 PRINTS PR00418 DNA topoisomerase II family signature 128 142 3.8E-70 T 13-10-2018 TOPB45_1486 f768a9dae9d04b9c5a1efbf4b5b522b8 817 PRINTS PR00418 DNA topoisomerase II family signature 282 295 3.8E-70 T 13-10-2018 TOPB45_1486 f768a9dae9d04b9c5a1efbf4b5b522b8 817 PRINTS PR00418 DNA topoisomerase II family signature 434 448 3.8E-70 T 13-10-2018 TOPB45_1486 f768a9dae9d04b9c5a1efbf4b5b522b8 817 PRINTS PR00418 DNA topoisomerase II family signature 85 98 3.8E-70 T 13-10-2018 TOPB45_1486 f768a9dae9d04b9c5a1efbf4b5b522b8 817 PRINTS PR00418 DNA topoisomerase II family signature 501 517 3.8E-70 T 13-10-2018 TOPB45_1486 f768a9dae9d04b9c5a1efbf4b5b522b8 817 Gene3D G3DSA:3.30.565.10 17 234 8.7E-90 T 13-10-2018 IPR036890 Histidine kinase/HSP90-like ATPase superfamily TOPB45_1486 f768a9dae9d04b9c5a1efbf4b5b522b8 817 Pfam PF00986 DNA gyrase B subunit, carboxyl terminus 745 805 8.6E-28 T 13-10-2018 IPR002288 DNA gyrase B subunit, C-terminal GO:0003677|GO:0003918|GO:0005524|GO:0006265 TOPB45_1486 f768a9dae9d04b9c5a1efbf4b5b522b8 817 ProSitePatterns PS00177 DNA topoisomerase II signature. 436 444 - T 13-10-2018 IPR018522 DNA topoisomerase, type IIA, conserved site GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TOPB45_1486 f768a9dae9d04b9c5a1efbf4b5b522b8 817 TIGRFAM TIGR01059 gyrB: DNA gyrase, B subunit 21 817 1.0E-290 T 13-10-2018 IPR011557 DNA gyrase, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0005694|GO:0006265 TOPB45_1486 f768a9dae9d04b9c5a1efbf4b5b522b8 817 SUPERFAMILY SSF56719 408 810 1.65E-85 T 13-10-2018 IPR013760 DNA topoisomerase, type IIA-like domain superfamily GO:0003918|GO:0005524 Reactome: R-HSA-4615885 TOPB45_1486 f768a9dae9d04b9c5a1efbf4b5b522b8 817 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 47 189 5.6E-19 T 13-10-2018 IPR003594 Histidine kinase/HSP90-like ATPase TOPB45_1486 f768a9dae9d04b9c5a1efbf4b5b522b8 817 SUPERFAMILY SSF55874 21 232 1.7E-71 T 13-10-2018 IPR036890 Histidine kinase/HSP90-like ATPase superfamily TOPB45_1486 f768a9dae9d04b9c5a1efbf4b5b522b8 817 SMART SM00433 50 810 3.7E-269 T 13-10-2018 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TOPB45_1486 f768a9dae9d04b9c5a1efbf4b5b522b8 817 SMART SM00387 46 190 6.9E-23 T 13-10-2018 IPR003594 Histidine kinase/HSP90-like ATPase TOPB45_1486 f768a9dae9d04b9c5a1efbf4b5b522b8 817 Gene3D G3DSA:3.40.50.670 412 600 1.0E-72 T 13-10-2018 IPR013759 DNA topoisomerase, type IIA, subunit B, C-terminal GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TOPB45_1486 f768a9dae9d04b9c5a1efbf4b5b522b8 817 Gene3D G3DSA:3.40.50.670 690 815 7.2E-25 T 13-10-2018 IPR013759 DNA topoisomerase, type IIA, subunit B, C-terminal GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TOPB45_1486 f768a9dae9d04b9c5a1efbf4b5b522b8 817 Pfam PF00204 DNA gyrase B 235 404 8.3E-62 T 13-10-2018 IPR013506 DNA topoisomerase, type IIA, subunit B, domain 2 GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TOPB45_1486 f768a9dae9d04b9c5a1efbf4b5b522b8 817 PRINTS PR01159 DNA gyrase subunit B signature 195 210 5.1E-63 T 13-10-2018 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 TOPB45_1486 f768a9dae9d04b9c5a1efbf4b5b522b8 817 PRINTS PR01159 DNA gyrase subunit B signature 210 223 5.1E-63 T 13-10-2018 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 TOPB45_1486 f768a9dae9d04b9c5a1efbf4b5b522b8 817 PRINTS PR01159 DNA gyrase subunit B signature 786 802 5.1E-63 T 13-10-2018 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 TOPB45_1486 f768a9dae9d04b9c5a1efbf4b5b522b8 817 PRINTS PR01159 DNA gyrase subunit B signature 234 256 5.1E-63 T 13-10-2018 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 TOPB45_1486 f768a9dae9d04b9c5a1efbf4b5b522b8 817 PRINTS PR01159 DNA gyrase subunit B signature 484 493 5.1E-63 T 13-10-2018 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 TOPB45_1486 f768a9dae9d04b9c5a1efbf4b5b522b8 817 PRINTS PR01159 DNA gyrase subunit B signature 388 408 5.1E-63 T 13-10-2018 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 TOPB45_1486 f768a9dae9d04b9c5a1efbf4b5b522b8 817 PRINTS PR01159 DNA gyrase subunit B signature 770 782 5.1E-63 T 13-10-2018 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 TOPB45_1486 f768a9dae9d04b9c5a1efbf4b5b522b8 817 PRINTS PR01159 DNA gyrase subunit B signature 326 342 5.1E-63 T 13-10-2018 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 TOPB45_1486 f768a9dae9d04b9c5a1efbf4b5b522b8 817 PRINTS PR01159 DNA gyrase subunit B signature 374 388 5.1E-63 T 13-10-2018 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 TOPB45_1486 f768a9dae9d04b9c5a1efbf4b5b522b8 817 PRINTS PR01159 DNA gyrase subunit B signature 21 31 5.1E-63 T 13-10-2018 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 TOPB45_1560 13c4d158cdc2ddea06a5c42d574a7fcf 459 Pfam PF03841 L-seryl-tRNA selenium transferase 72 436 8.8E-165 T 13-10-2018 IPR018319 L-seryl-tRNA selenium transferase-like KEGG: 00450+2.9.1.1|KEGG: 00970+2.9.1.1 TOPB45_1560 13c4d158cdc2ddea06a5c42d574a7fcf 459 Hamap MF_00423 L-seryl-tRNA(Sec) selenium transferase [selA]. 1 454 205.147 T 13-10-2018 IPR004534 L-seryl-tRNA(Sec) selenium transferase GO:0001514|GO:0004125|GO:0005737 KEGG: 00450+2.9.1.1|KEGG: 00970+2.9.1.1 TOPB45_1560 13c4d158cdc2ddea06a5c42d574a7fcf 459 TIGRFAM TIGR00474 selA: L-seryl-tRNA(Sec) selenium transferase 2 449 1.2E-187 T 13-10-2018 IPR004534 L-seryl-tRNA(Sec) selenium transferase GO:0001514|GO:0004125|GO:0005737 KEGG: 00450+2.9.1.1|KEGG: 00970+2.9.1.1 TOPB45_1560 13c4d158cdc2ddea06a5c42d574a7fcf 459 SUPERFAMILY SSF53383 62 453 2.76E-53 T 13-10-2018 IPR015424 Pyridoxal phosphate-dependent transferase TOPB45_1560 13c4d158cdc2ddea06a5c42d574a7fcf 459 Gene3D G3DSA:3.90.1150.110 3 441 4.4E-177 T 13-10-2018 TOPB45_1560 13c4d158cdc2ddea06a5c42d574a7fcf 459 Gene3D G3DSA:3.40.640.10 84 348 4.4E-177 T 13-10-2018 IPR015421 Pyridoxal phosphate-dependent transferase, major domain GO:0003824 TOPB45_0855 0b2fb9cf6eb90fbbbba8adf39d7a2059 151 Pfam PF04343 Protein of unknown function, DUF488 14 119 4.6E-23 T 13-10-2018 IPR007438 Protein of unknown function DUF488 TOPB45_0855 0b2fb9cf6eb90fbbbba8adf39d7a2059 151 PIRSF PIRSF024492 1 147 1.4E-41 T 13-10-2018 IPR014519 Uncharacterised conserved protein UCP024492 TOPB45_0980 c5fdef80ec6557631050fa6cc0066de9 789 PIRSF PIRSF001174 11 789 0.0 T 13-10-2018 IPR004815 Lon protease, bacterial/eukaryotic-type GO:0004176|GO:0005524|GO:0006508 TOPB45_0980 c5fdef80ec6557631050fa6cc0066de9 789 ProSitePatterns PS01046 ATP-dependent serine proteases, lon family, serine active site. 691 699 - T 13-10-2018 IPR008268 Peptidase S16, active site GO:0004176|GO:0004252|GO:0006508 TOPB45_0980 c5fdef80ec6557631050fa6cc0066de9 789 TIGRFAM TIGR00763 lon: endopeptidase La 25 785 1.3E-303 T 13-10-2018 IPR004815 Lon protease, bacterial/eukaryotic-type GO:0004176|GO:0005524|GO:0006508 TOPB45_0980 c5fdef80ec6557631050fa6cc0066de9 789 Hamap MF_01973 Lon protease [lon]. 24 787 70.921 T 13-10-2018 IPR027543 Lon protease, bacterial GO:0004176|GO:0004252|GO:0005524|GO:0006508|GO:0043565 TOPB45_0980 c5fdef80ec6557631050fa6cc0066de9 789 Pfam PF05362 Lon protease (S16) C-terminal proteolytic domain 585 786 3.0E-92 T 13-10-2018 IPR008269 Peptidase S16, Lon proteolytic domain GO:0004176|GO:0004252|GO:0006508 TOPB45_0980 c5fdef80ec6557631050fa6cc0066de9 789 SMART SM00464 23 217 1.2E-57 T 13-10-2018 IPR003111 Lon, substrate-binding domain TOPB45_0980 c5fdef80ec6557631050fa6cc0066de9 789 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 367 505 7.8E-22 T 13-10-2018 IPR003959 ATPase, AAA-type, core GO:0005524 TOPB45_0980 c5fdef80ec6557631050fa6cc0066de9 789 SMART SM00382 363 508 6.5E-12 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_0980 c5fdef80ec6557631050fa6cc0066de9 789 Gene3D G3DSA:2.30.130.40 17 128 2.4E-32 T 13-10-2018 TOPB45_0980 c5fdef80ec6557631050fa6cc0066de9 789 Gene3D G3DSA:3.40.50.300 328 506 1.6E-66 T 13-10-2018 TOPB45_0980 c5fdef80ec6557631050fa6cc0066de9 789 PRINTS PR00830 Endopeptidase La (Lon) serine protease (S16) signature 718 737 7.6E-52 T 13-10-2018 TOPB45_0980 c5fdef80ec6557631050fa6cc0066de9 789 PRINTS PR00830 Endopeptidase La (Lon) serine protease (S16) signature 688 707 7.6E-52 T 13-10-2018 TOPB45_0980 c5fdef80ec6557631050fa6cc0066de9 789 PRINTS PR00830 Endopeptidase La (Lon) serine protease (S16) signature 741 759 7.6E-52 T 13-10-2018 TOPB45_0980 c5fdef80ec6557631050fa6cc0066de9 789 PRINTS PR00830 Endopeptidase La (Lon) serine protease (S16) signature 371 390 7.6E-52 T 13-10-2018 TOPB45_0980 c5fdef80ec6557631050fa6cc0066de9 789 PRINTS PR00830 Endopeptidase La (Lon) serine protease (S16) signature 610 626 7.6E-52 T 13-10-2018 TOPB45_0980 c5fdef80ec6557631050fa6cc0066de9 789 SUPERFAMILY SSF88697 24 215 2.98E-41 T 13-10-2018 IPR015947 PUA-like superfamily TOPB45_0980 c5fdef80ec6557631050fa6cc0066de9 789 Pfam PF02190 ATP-dependent protease La (LON) substrate-binding domain 24 215 2.2E-37 T 13-10-2018 IPR003111 Lon, substrate-binding domain TOPB45_0980 c5fdef80ec6557631050fa6cc0066de9 789 Gene3D G3DSA:3.30.230.10 608 789 1.0E-81 T 13-10-2018 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup TOPB45_0980 c5fdef80ec6557631050fa6cc0066de9 789 SUPERFAMILY SSF54211 610 785 3.45E-58 T 13-10-2018 IPR020568 Ribosomal protein S5 domain 2-type fold TOPB45_0980 c5fdef80ec6557631050fa6cc0066de9 789 Gene3D G3DSA:1.20.58.1480 137 261 2.0E-35 T 13-10-2018 TOPB45_0980 c5fdef80ec6557631050fa6cc0066de9 789 SUPERFAMILY SSF52540 325 601 8.77E-52 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0980 c5fdef80ec6557631050fa6cc0066de9 789 Gene3D G3DSA:1.10.8.60 507 599 2.3E-32 T 13-10-2018 TOPB45_1599 a295effa1273cfb9ca5b981fe2a5cdbf 97 SUPERFAMILY SSF54862 28 93 1.16E-19 T 13-10-2018 TOPB45_1599 a295effa1273cfb9ca5b981fe2a5cdbf 97 Pfam PF14697 4Fe-4S dicluster domain 39 92 8.9E-9 T 13-10-2018 TOPB45_1599 a295effa1273cfb9ca5b981fe2a5cdbf 97 TIGRFAM TIGR02179 PorD_KorD: 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family 20 96 1.1E-28 T 13-10-2018 IPR011898 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate GO:0016625|GO:0051539 TOPB45_1599 a295effa1273cfb9ca5b981fe2a5cdbf 97 Gene3D G3DSA:3.30.70.20 56 97 2.7E-6 T 13-10-2018 TOPB45_1599 a295effa1273cfb9ca5b981fe2a5cdbf 97 Gene3D G3DSA:3.30.70.20 21 55 2.8E-5 T 13-10-2018 TOPB45_1599 a295effa1273cfb9ca5b981fe2a5cdbf 97 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 75 86 - T 13-10-2018 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site TOPB45_1165 ea09e4815fbb5f59d20b39a66ff70af0 343 TIGRFAM TIGR02195 heptsyl_trn_II: lipopolysaccharide heptosyltransferase II 2 336 2.4E-43 T 13-10-2018 IPR011910 ADP-heptose--LPS heptosyltransferase 2 GO:0009103|GO:0016757 TOPB45_1165 ea09e4815fbb5f59d20b39a66ff70af0 343 Gene3D G3DSA:3.40.50.2000 1 152 1.2E-41 T 13-10-2018 TOPB45_1165 ea09e4815fbb5f59d20b39a66ff70af0 343 Pfam PF01075 Glycosyltransferase family 9 (heptosyltransferase) 70 319 1.0E-55 T 13-10-2018 IPR002201 Glycosyl transferase, family 9 GO:0016757 TOPB45_1165 ea09e4815fbb5f59d20b39a66ff70af0 343 TIGRFAM TIGR02193 heptsyl_trn_I: lipopolysaccharide heptosyltransferase I 2 336 2.4E-59 T 13-10-2018 IPR011908 Lipopolysaccharide heptosyltransferase I GO:0008920|GO:0009244 TOPB45_1165 ea09e4815fbb5f59d20b39a66ff70af0 343 SUPERFAMILY SSF53756 2 336 2.83E-87 T 13-10-2018 TOPB45_1165 ea09e4815fbb5f59d20b39a66ff70af0 343 Gene3D G3DSA:3.40.50.2000 166 340 3.7E-47 T 13-10-2018 TOPB45_1063 1a9a74d4cc48a3b8cd176e4a0077af37 429 SUPERFAMILY SSF53623 5 282 6.18E-91 T 13-10-2018 IPR036565 Mur-like, catalytic domain superfamily GO:0005524|GO:0009058 Reactome: R-HSA-196757 TOPB45_1063 1a9a74d4cc48a3b8cd176e4a0077af37 429 ProSitePatterns PS01012 Folylpolyglutamate synthase signature 2. 133 148 - T 13-10-2018 IPR018109 Folylpolyglutamate synthetase, conserved site GO:0004326|GO:0005524|GO:0009396 Reactome: R-HSA-196757 TOPB45_1063 1a9a74d4cc48a3b8cd176e4a0077af37 429 Pfam PF08245 Mur ligase middle domain 43 257 3.8E-13 T 13-10-2018 IPR013221 Mur ligase, central GO:0005524|GO:0009058 TOPB45_1063 1a9a74d4cc48a3b8cd176e4a0077af37 429 Gene3D G3DSA:3.40.1190.10 3 285 1.1E-97 T 13-10-2018 IPR036565 Mur-like, catalytic domain superfamily GO:0005524|GO:0009058 Reactome: R-HSA-196757 TOPB45_1063 1a9a74d4cc48a3b8cd176e4a0077af37 429 TIGRFAM TIGR01499 folC: bifunctional protein FolC 21 420 3.9E-115 T 13-10-2018 IPR001645 Folylpolyglutamate synthetase GO:0004326|GO:0005524|GO:0009396 KEGG: 00790+6.3.2.17|MetaCyc: PWY-2161|Reactome: R-HSA-196757 TOPB45_1063 1a9a74d4cc48a3b8cd176e4a0077af37 429 Gene3D G3DSA:3.90.190.20 286 427 4.4E-21 T 13-10-2018 IPR036615 Mur ligase, C-terminal domain superfamily GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 TOPB45_1063 1a9a74d4cc48a3b8cd176e4a0077af37 429 PIRSF PIRSF001563 1 426 2.8E-129 T 13-10-2018 IPR001645 Folylpolyglutamate synthetase GO:0004326|GO:0005524|GO:0009396 KEGG: 00790+6.3.2.17|MetaCyc: PWY-2161|Reactome: R-HSA-196757 TOPB45_1063 1a9a74d4cc48a3b8cd176e4a0077af37 429 SUPERFAMILY SSF53244 286 423 3.43E-18 T 13-10-2018 IPR036615 Mur ligase, C-terminal domain superfamily GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 TOPB45_0182 e27139606a22e1bfd03e537ca1d0934c 772 Gene3D G3DSA:3.40.50.300 556 764 1.5E-15 T 13-10-2018 TOPB45_0182 e27139606a22e1bfd03e537ca1d0934c 772 Gene3D G3DSA:3.40.50.300 257 372 1.9E-18 T 13-10-2018 TOPB45_0182 e27139606a22e1bfd03e537ca1d0934c 772 Pfam PF00580 UvrD/REP helicase N-terminal domain 6 342 2.3E-31 T 13-10-2018 IPR034739 UvrD/AddA helicase, N-terminal GO:0005524 TOPB45_0182 e27139606a22e1bfd03e537ca1d0934c 772 Gene3D G3DSA:3.40.50.300 444 538 5.3E-6 T 13-10-2018 TOPB45_0182 e27139606a22e1bfd03e537ca1d0934c 772 Pfam PF13361 UvrD-like helicase C-terminal domain 351 736 5.3E-23 T 13-10-2018 IPR014017 UvrD-like DNA helicase, C-terminal GO:0005524|GO:0016787 TOPB45_0182 e27139606a22e1bfd03e537ca1d0934c 772 SUPERFAMILY SSF52540 4 740 1.69E-64 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1006 ad7356ac38bf54ac0dfb6355fe47b790 865 Gene3D G3DSA:3.30.70.3220 134 250 9.0E-22 T 13-10-2018 TOPB45_1006 ad7356ac38bf54ac0dfb6355fe47b790 865 Hamap MF_01464_B Protein-export membrane protein SecF [secF]. 566 854 25.505 T 13-10-2018 IPR005665 Protein-export membrane protein SecF, bacterial GO:0006886|GO:0015450 TOPB45_1006 ad7356ac38bf54ac0dfb6355fe47b790 865 TIGRFAM TIGR00966 3a0501s07: protein-export membrane protein SecF 599 843 4.8E-70 T 13-10-2018 IPR005665 Protein-export membrane protein SecF, bacterial GO:0006886|GO:0015450 TOPB45_1006 ad7356ac38bf54ac0dfb6355fe47b790 865 SUPERFAMILY SSF82866 299 549 1.14E-41 T 13-10-2018 TOPB45_1006 ad7356ac38bf54ac0dfb6355fe47b790 865 SUPERFAMILY SSF82866 655 854 4.45E-36 T 13-10-2018 TOPB45_1006 ad7356ac38bf54ac0dfb6355fe47b790 865 Gene3D G3DSA:3.30.1360.200 256 368 6.0E-42 T 13-10-2018 TOPB45_1006 ad7356ac38bf54ac0dfb6355fe47b790 865 TIGRFAM TIGR00916 2A0604s01: protein-export membrane protein, SecD/SecF family 306 536 4.5E-79 T 13-10-2018 IPR022645 Protein-export membrane protein SecD/SecF, bacterial TOPB45_1006 ad7356ac38bf54ac0dfb6355fe47b790 865 TIGRFAM TIGR00916 2A0604s01: protein-export membrane protein, SecD/SecF family 661 840 5.2E-46 T 13-10-2018 IPR022645 Protein-export membrane protein SecD/SecF, bacterial TOPB45_1006 ad7356ac38bf54ac0dfb6355fe47b790 865 Gene3D G3DSA:1.20.1640.10 369 557 1.3E-10 T 13-10-2018 TOPB45_1006 ad7356ac38bf54ac0dfb6355fe47b790 865 Gene3D G3DSA:1.20.1640.10 655 857 7.2E-12 T 13-10-2018 TOPB45_1006 ad7356ac38bf54ac0dfb6355fe47b790 865 Pfam PF07549 SecD/SecF GG Motif 44 60 0.0026 T 13-10-2018 IPR022646 Protein-export membrane protein SecD/SecF/SecDF, conserved site TOPB45_1006 ad7356ac38bf54ac0dfb6355fe47b790 865 Pfam PF07549 SecD/SecF GG Motif 599 613 2.8E-4 T 13-10-2018 IPR022646 Protein-export membrane protein SecD/SecF/SecDF, conserved site TOPB45_1006 ad7356ac38bf54ac0dfb6355fe47b790 865 Hamap MF_01463_B Protein translocase subunit SecD [secD]. 2 558 43.146 T 13-10-2018 IPR005791 Protein translocase subunit SecD GO:0006886|GO:0015450 TOPB45_1006 ad7356ac38bf54ac0dfb6355fe47b790 865 PRINTS PR01755 Bacterial translocase SecF protein signature 791 806 1.2E-22 T 13-10-2018 IPR022645 Protein-export membrane protein SecD/SecF, bacterial TOPB45_1006 ad7356ac38bf54ac0dfb6355fe47b790 865 PRINTS PR01755 Bacterial translocase SecF protein signature 711 725 1.2E-22 T 13-10-2018 IPR022645 Protein-export membrane protein SecD/SecF, bacterial TOPB45_1006 ad7356ac38bf54ac0dfb6355fe47b790 865 PRINTS PR01755 Bacterial translocase SecF protein signature 759 777 1.2E-22 T 13-10-2018 IPR022645 Protein-export membrane protein SecD/SecF, bacterial TOPB45_1006 ad7356ac38bf54ac0dfb6355fe47b790 865 PRINTS PR01755 Bacterial translocase SecF protein signature 596 611 1.2E-22 T 13-10-2018 IPR022645 Protein-export membrane protein SecD/SecF, bacterial TOPB45_1006 ad7356ac38bf54ac0dfb6355fe47b790 865 Pfam PF02355 Protein export membrane protein 676 852 2.0E-56 T 13-10-2018 IPR022813 Protein-export membrane protein SecD/SecF, archaeal and bacterial TOPB45_1006 ad7356ac38bf54ac0dfb6355fe47b790 865 Pfam PF02355 Protein export membrane protein 377 544 3.4E-18 T 13-10-2018 IPR022813 Protein-export membrane protein SecD/SecF, archaeal and bacterial TOPB45_1006 ad7356ac38bf54ac0dfb6355fe47b790 865 TIGRFAM TIGR01129 secD: protein-export membrane protein SecD 46 542 1.0E-144 T 13-10-2018 IPR005791 Protein translocase subunit SecD GO:0006886|GO:0015450 TOPB45_0624 f0e756b9c067b23d79796cad1c1eecbb 272 PIRSF PIRSF000193 4 272 4.2E-81 T 13-10-2018 IPR000304 Pyrroline-5-carboxylate reductase GO:0004735|GO:0006561|GO:0055114 KEGG: 00330+1.5.1.2|MetaCyc: PWY-3341|MetaCyc: PWY-4981|MetaCyc: PWY-6344|Reactome: R-HSA-70614 TOPB45_0624 f0e756b9c067b23d79796cad1c1eecbb 272 Hamap MF_01925 Pyrroline-5-carboxylate reductase [proC]. 5 269 26.121 T 13-10-2018 IPR000304 Pyrroline-5-carboxylate reductase GO:0004735|GO:0006561|GO:0055114 KEGG: 00330+1.5.1.2|MetaCyc: PWY-3341|MetaCyc: PWY-4981|MetaCyc: PWY-6344|Reactome: R-HSA-70614 TOPB45_0624 f0e756b9c067b23d79796cad1c1eecbb 272 SUPERFAMILY SSF51735 5 163 1.21E-32 T 13-10-2018 IPR036291 NAD(P)-binding domain superfamily TOPB45_0624 f0e756b9c067b23d79796cad1c1eecbb 272 Gene3D G3DSA:1.10.3730.10 167 272 2.3E-35 T 13-10-2018 TOPB45_0624 f0e756b9c067b23d79796cad1c1eecbb 272 Pfam PF14748 Pyrroline-5-carboxylate reductase dimerisation 165 269 6.5E-34 T 13-10-2018 IPR029036 Pyrroline-5-carboxylate reductase, dimerisation domain KEGG: 00330+1.5.1.2|MetaCyc: PWY-3341|MetaCyc: PWY-4981|MetaCyc: PWY-6344|Reactome: R-HSA-70614 TOPB45_0624 f0e756b9c067b23d79796cad1c1eecbb 272 Gene3D G3DSA:3.40.50.720 3 166 5.3E-51 T 13-10-2018 TOPB45_0624 f0e756b9c067b23d79796cad1c1eecbb 272 Pfam PF03807 NADP oxidoreductase coenzyme F420-dependent 6 98 6.1E-21 T 13-10-2018 IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal TOPB45_0624 f0e756b9c067b23d79796cad1c1eecbb 272 TIGRFAM TIGR00112 proC: pyrroline-5-carboxylate reductase 7 269 1.0E-83 T 13-10-2018 IPR000304 Pyrroline-5-carboxylate reductase GO:0004735|GO:0006561|GO:0055114 KEGG: 00330+1.5.1.2|MetaCyc: PWY-3341|MetaCyc: PWY-4981|MetaCyc: PWY-6344|Reactome: R-HSA-70614 TOPB45_0624 f0e756b9c067b23d79796cad1c1eecbb 272 SUPERFAMILY SSF48179 164 271 1.7E-33 T 13-10-2018 IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily GO:0055114 TOPB45_1581 a92c6bb8505b2b5aca0c4030ee80966c 72 Pfam PF16256 Domain of unknown function (DUF4911) 8 62 1.5E-19 T 13-10-2018 IPR032587 Protein of unknown function DUF4911 TOPB45_1572 eab96f96e8487f9d5ba264ce7f6a3c32 256 SUPERFAMILY SSF117143 86 215 2.22E-22 T 13-10-2018 IPR037925 Flagellar hook-basal body protein, FlgE/F/G-like TOPB45_1572 eab96f96e8487f9d5ba264ce7f6a3c32 256 TIGRFAM TIGR03506 FlgEFG_subfam: flagellar hook-basal body protein 16 129 1.6E-37 T 13-10-2018 IPR020013 Flagellar hook-basal body protein, FlgE/F/G TOPB45_1572 eab96f96e8487f9d5ba264ce7f6a3c32 256 ProSitePatterns PS00588 Flagella basal body rod proteins signature. 20 40 - T 13-10-2018 IPR019776 Flagellar basal body rod protein, conserved site TOPB45_1572 eab96f96e8487f9d5ba264ce7f6a3c32 256 TIGRFAM TIGR02490 flgF: flagellar basal-body rod protein FlgF 17 234 6.2E-57 T 13-10-2018 IPR012836 Flagellar basal-body rod FlgF GO:0030694|GO:0071973 TOPB45_1572 eab96f96e8487f9d5ba264ce7f6a3c32 256 Pfam PF00460 Flagella basal body rod protein 17 44 2.8E-8 T 13-10-2018 IPR001444 Flagellar basal body rod protein, N-terminal GO:0071973 TOPB45_1572 eab96f96e8487f9d5ba264ce7f6a3c32 256 Pfam PF06429 Flagellar basal body rod FlgEFG protein C-terminal 184 251 3.9E-17 T 13-10-2018 IPR010930 Flagellar basal-body/hook protein, C-terminal domain TOPB45_1351 4f0ff1799ac9a540e8dda00b35a1e038 405 Pfam PF03471 Transporter associated domain 329 403 6.4E-16 T 13-10-2018 IPR005170 Transporter-associated domain TOPB45_1351 4f0ff1799ac9a540e8dda00b35a1e038 405 Gene3D G3DSA:3.10.580.10 173 323 2.3E-37 T 13-10-2018 TOPB45_1351 4f0ff1799ac9a540e8dda00b35a1e038 405 Pfam PF01595 Domain of unknown function DUF21 8 156 2.6E-29 T 13-10-2018 IPR002550 CNNM, transmembrane domain TOPB45_1351 4f0ff1799ac9a540e8dda00b35a1e038 405 SUPERFAMILY SSF56176 326 404 1.23E-16 T 13-10-2018 IPR036318 FAD-binding, type PCMH-like superfamily GO:0050660 TOPB45_1351 4f0ff1799ac9a540e8dda00b35a1e038 405 Pfam PF00571 CBS domain 265 313 0.0011 T 13-10-2018 IPR000644 CBS domain TOPB45_1351 4f0ff1799ac9a540e8dda00b35a1e038 405 SUPERFAMILY SSF54631 189 331 6.06E-23 T 13-10-2018 TOPB45_1351 4f0ff1799ac9a540e8dda00b35a1e038 405 SMART SM01091 328 405 6.0E-18 T 13-10-2018 IPR005170 Transporter-associated domain TOPB45_1351 4f0ff1799ac9a540e8dda00b35a1e038 405 Gene3D G3DSA:3.30.465.10 324 405 3.0E-17 T 13-10-2018 IPR016169 FAD-binding, type PCMH, subdomain 2 TOPB45_0890 7a99893feb2f370aaf235cde660cfb41 80 PIRSF PIRSF037031 1 77 4.9E-26 T 13-10-2018 IPR005243 Redox-active disulphide protein 2 TOPB45_0890 7a99893feb2f370aaf235cde660cfb41 80 Gene3D G3DSA:3.40.30.10 1 76 4.0E-26 T 13-10-2018 TOPB45_0890 7a99893feb2f370aaf235cde660cfb41 80 SUPERFAMILY SSF52833 2 75 1.92E-15 T 13-10-2018 IPR036249 Thioredoxin-like superfamily TOPB45_0890 7a99893feb2f370aaf235cde660cfb41 80 TIGRFAM TIGR00412 redox_disulf_2: redox-active disulfide protein 2 1 77 1.4E-23 T 13-10-2018 IPR005243 Redox-active disulphide protein 2 TOPB45_0890 7a99893feb2f370aaf235cde660cfb41 80 Pfam PF13192 Thioredoxin domain 1 75 6.7E-23 T 13-10-2018 IPR012336 Thioredoxin-like fold TOPB45_1577 2d9fb0131b7e4e7de0d651edc6264613 300 Gene3D G3DSA:1.10.443.10 106 298 1.2E-56 T 13-10-2018 IPR013762 Integrase-like, catalytic domain superfamily GO:0003677|GO:0006310|GO:0015074 TOPB45_1577 2d9fb0131b7e4e7de0d651edc6264613 300 Hamap MF_01808 Tyrosine recombinase XerC [xerC]. 4 297 51.973 T 13-10-2018 IPR023009 Tyrosine recombinase XerC/XerD TOPB45_1577 2d9fb0131b7e4e7de0d651edc6264613 300 SUPERFAMILY SSF56349 3 291 2.03E-58 T 13-10-2018 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 TOPB45_1577 2d9fb0131b7e4e7de0d651edc6264613 300 Gene3D G3DSA:1.10.150.130 1 105 5.4E-25 T 13-10-2018 IPR010998 Integrase/recombinase, N-terminal TOPB45_1577 2d9fb0131b7e4e7de0d651edc6264613 300 Pfam PF02899 Phage integrase, N-terminal SAM-like domain 6 89 2.0E-21 T 13-10-2018 IPR004107 Integrase, SAM-like, N-terminal GO:0003677|GO:0015074 TOPB45_1577 2d9fb0131b7e4e7de0d651edc6264613 300 Pfam PF00589 Phage integrase family 114 283 7.7E-46 T 13-10-2018 IPR002104 Integrase, catalytic domain GO:0003677|GO:0006310|GO:0015074 TOPB45_1079 fd5765ad026db0c9d92af88bd7493921 859 SUPERFAMILY SSF50447 762 855 2.55E-33 T 13-10-2018 IPR009000 Translation protein, beta-barrel domain superfamily TOPB45_1079 fd5765ad026db0c9d92af88bd7493921 859 Pfam PF00009 Elongation factor Tu GTP binding domain 363 519 2.0E-35 T 13-10-2018 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TOPB45_1079 fd5765ad026db0c9d92af88bd7493921 859 SUPERFAMILY SSF52156 638 766 6.02E-40 T 13-10-2018 IPR036925 Translation initiation factor IF-2, domain 3 superfamily TOPB45_1079 fd5765ad026db0c9d92af88bd7493921 859 Gene3D G3DSA:1.10.10.2480 1 68 1.7E-13 T 13-10-2018 TOPB45_1079 fd5765ad026db0c9d92af88bd7493921 859 Hamap MF_00100_B Translation initiation factor IF-2 [infB]. 3 857 17.806 T 13-10-2018 IPR000178 Translation initiation factor aIF-2, bacterial-like GO:0003743|GO:0005525|GO:0005622|GO:0006413 Reactome: R-HSA-5368286 TOPB45_1079 fd5765ad026db0c9d92af88bd7493921 859 Gene3D G3DSA:3.40.50.300 355 530 3.8E-72 T 13-10-2018 TOPB45_1079 fd5765ad026db0c9d92af88bd7493921 859 Gene3D G3DSA:2.40.30.10 531 648 2.3E-43 T 13-10-2018 TOPB45_1079 fd5765ad026db0c9d92af88bd7493921 859 TIGRFAM TIGR00487 IF-2: translation initiation factor IF-2 276 855 2.9E-263 T 13-10-2018 IPR000178 Translation initiation factor aIF-2, bacterial-like GO:0003743|GO:0005525|GO:0005622|GO:0006413 Reactome: R-HSA-5368286 TOPB45_1079 fd5765ad026db0c9d92af88bd7493921 859 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 361 518 4.2E-35 T 13-10-2018 IPR005225 Small GTP-binding protein domain GO:0005525 TOPB45_1079 fd5765ad026db0c9d92af88bd7493921 859 SUPERFAMILY SSF52540 353 528 4.57E-53 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1079 fd5765ad026db0c9d92af88bd7493921 859 SUPERFAMILY SSF50447 532 615 2.08E-27 T 13-10-2018 IPR009000 Translation protein, beta-barrel domain superfamily TOPB45_1079 fd5765ad026db0c9d92af88bd7493921 859 ProSitePatterns PS01176 Initiation factor 2 signature. 810 832 - T 13-10-2018 IPR000178 Translation initiation factor aIF-2, bacterial-like GO:0003743|GO:0005525|GO:0005622|GO:0006413 Reactome: R-HSA-5368286 TOPB45_1079 fd5765ad026db0c9d92af88bd7493921 859 Pfam PF11987 Translation-initiation factor 2 644 749 7.4E-40 T 13-10-2018 IPR023115 Translation initiation factor IF- 2, domain 3 TOPB45_1079 fd5765ad026db0c9d92af88bd7493921 859 Pfam PF04760 Translation initiation factor IF-2, N-terminal region 284 333 1.0E-14 T 13-10-2018 IPR006847 Translation initiation factor IF-2, N-terminal TOPB45_1079 fd5765ad026db0c9d92af88bd7493921 859 Pfam PF04760 Translation initiation factor IF-2, N-terminal region 1 53 1.8E-16 T 13-10-2018 IPR006847 Translation initiation factor IF-2, N-terminal TOPB45_1079 fd5765ad026db0c9d92af88bd7493921 859 Gene3D G3DSA:3.40.50.10050 653 760 7.5E-41 T 13-10-2018 IPR036925 Translation initiation factor IF-2, domain 3 superfamily TOPB45_1079 fd5765ad026db0c9d92af88bd7493921 859 Gene3D G3DSA:2.40.30.10 761 857 3.7E-35 T 13-10-2018 TOPB45_0034 2e105cbeb26a44c627320bcf9ef6dc58 242 Pfam PF00005 ABC transporter 17 165 5.1E-36 T 13-10-2018 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TOPB45_0034 2e105cbeb26a44c627320bcf9ef6dc58 242 ProSitePatterns PS00211 ABC transporters family signature. 138 152 - T 13-10-2018 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TOPB45_0034 2e105cbeb26a44c627320bcf9ef6dc58 242 Gene3D G3DSA:3.40.50.300 1 241 4.5E-76 T 13-10-2018 TOPB45_0034 2e105cbeb26a44c627320bcf9ef6dc58 242 SUPERFAMILY SSF52540 1 231 7.7E-72 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0034 2e105cbeb26a44c627320bcf9ef6dc58 242 SMART SM00382 26 215 2.6E-9 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_1523 e095fcc12413f7d9aa361bcf227a0984 485 SMART SM00028 427 460 0.17 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_1523 e095fcc12413f7d9aa361bcf227a0984 485 SMART SM00028 390 423 140.0 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_1523 e095fcc12413f7d9aa361bcf227a0984 485 Gene3D G3DSA:1.25.40.10 385 484 1.5E-7 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_1523 e095fcc12413f7d9aa361bcf227a0984 485 Pfam PF02624 YcaO cyclodehydratase, ATP-ad Mg2+-binding 73 381 3.7E-68 T 13-10-2018 IPR003776 YcaO-like domain TOPB45_1523 e095fcc12413f7d9aa361bcf227a0984 485 Gene3D G3DSA:3.30.160.660 209 335 4.4E-32 T 13-10-2018 TOPB45_1523 e095fcc12413f7d9aa361bcf227a0984 485 Gene3D G3DSA:1.10.490.140 81 382 4.4E-32 T 13-10-2018 TOPB45_1523 e095fcc12413f7d9aa361bcf227a0984 485 SUPERFAMILY SSF48452 391 459 5.06E-8 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_1523 e095fcc12413f7d9aa361bcf227a0984 485 Gene3D G3DSA:2.40.50.820 104 172 4.4E-32 T 13-10-2018 TOPB45_1523 e095fcc12413f7d9aa361bcf227a0984 485 TIGRFAM TIGR00702 TIGR00702: YcaO-type kinase domain 17 294 5.0E-42 T 13-10-2018 IPR003776 YcaO-like domain TOPB45_1264 896a9d6fa0f6e83b7e9a7d6f7bb080f5 65 SUPERFAMILY SSF54862 4 64 1.4E-15 T 13-10-2018 TOPB45_1264 896a9d6fa0f6e83b7e9a7d6f7bb080f5 65 Gene3D G3DSA:3.30.70.20 2 65 8.6E-22 T 13-10-2018 TOPB45_1264 896a9d6fa0f6e83b7e9a7d6f7bb080f5 65 PRINTS PR00352 3Fe-4S ferredoxin signature 18 28 3.9E-10 T 13-10-2018 IPR001080 3Fe-4S ferredoxin GO:0005506|GO:0009055 TOPB45_1264 896a9d6fa0f6e83b7e9a7d6f7bb080f5 65 PRINTS PR00352 3Fe-4S ferredoxin signature 48 60 3.9E-10 T 13-10-2018 IPR001080 3Fe-4S ferredoxin GO:0005506|GO:0009055 TOPB45_1264 896a9d6fa0f6e83b7e9a7d6f7bb080f5 65 PRINTS PR00352 3Fe-4S ferredoxin signature 7 18 3.9E-10 T 13-10-2018 IPR001080 3Fe-4S ferredoxin GO:0005506|GO:0009055 TOPB45_1264 896a9d6fa0f6e83b7e9a7d6f7bb080f5 65 Pfam PF13370 4Fe-4S single cluster domain of Ferredoxin I 7 62 4.4E-15 T 13-10-2018 TOPB45_1264 896a9d6fa0f6e83b7e9a7d6f7bb080f5 65 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 12 23 - T 13-10-2018 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site TOPB45_0947 689ec61df02418db8ebcbb2332d299cd 413 TIGRFAM TIGR01174 ftsA: cell division protein FtsA 7 381 9.1E-123 T 13-10-2018 IPR020823 Cell division protein FtsA TOPB45_0947 689ec61df02418db8ebcbb2332d299cd 413 Hamap MF_02033 Cell division protein FtsA [ftsA]. 3 410 27.656 T 13-10-2018 IPR020823 Cell division protein FtsA TOPB45_0947 689ec61df02418db8ebcbb2332d299cd 413 Gene3D G3DSA:3.30.420.40 193 356 1.5E-114 T 13-10-2018 TOPB45_0947 689ec61df02418db8ebcbb2332d299cd 413 PIRSF PIRSF003101 1 412 1.5E-129 T 13-10-2018 IPR020823 Cell division protein FtsA TOPB45_0947 689ec61df02418db8ebcbb2332d299cd 413 Gene3D G3DSA:3.30.420.40 10 375 1.5E-114 T 13-10-2018 TOPB45_0947 689ec61df02418db8ebcbb2332d299cd 413 SUPERFAMILY SSF53067 194 381 1.18E-39 T 13-10-2018 TOPB45_0947 689ec61df02418db8ebcbb2332d299cd 413 Pfam PF14450 Cell division protein FtsA 203 378 1.6E-19 T 13-10-2018 TOPB45_0947 689ec61df02418db8ebcbb2332d299cd 413 SMART SM00842 7 192 2.1E-82 T 13-10-2018 IPR003494 SHS2 domain inserted in FtsA GO:0005515|GO:0051301 TOPB45_0947 689ec61df02418db8ebcbb2332d299cd 413 Pfam PF02491 SHS2 domain inserted in FTSA 81 158 1.1E-26 T 13-10-2018 IPR003494 SHS2 domain inserted in FtsA GO:0005515|GO:0051301 TOPB45_0947 689ec61df02418db8ebcbb2332d299cd 413 Gene3D G3DSA:3.90.640.10 231 296 1.5E-114 T 13-10-2018 TOPB45_0947 689ec61df02418db8ebcbb2332d299cd 413 Gene3D G3DSA:3.30.1490.110 83 165 1.5E-114 T 13-10-2018 TOPB45_0947 689ec61df02418db8ebcbb2332d299cd 413 SUPERFAMILY SSF53067 7 193 1.94E-50 T 13-10-2018 TOPB45_0647 64079e2ff1e856b2527c91a0434ff3ae 433 Pfam PF00501 AMP-binding enzyme 85 288 4.0E-20 T 13-10-2018 IPR000873 AMP-dependent synthetase/ligase GO:0003824 TOPB45_0647 64079e2ff1e856b2527c91a0434ff3ae 433 Gene3D G3DSA:3.30.300.30 330 432 3.5E-31 T 13-10-2018 TOPB45_0647 64079e2ff1e856b2527c91a0434ff3ae 433 PIRSF PIRSF006444 1 433 2.8E-172 T 13-10-2018 IPR011880 Phenylacetate-CoA ligase GO:0010124|GO:0047475 KEGG: 00360+6.2.1.30|MetaCyc: PWY-1341|MetaCyc: PWY-6318|MetaCyc: PWY-7716 TOPB45_0647 64079e2ff1e856b2527c91a0434ff3ae 433 SUPERFAMILY SSF56801 33 375 3.27E-56 T 13-10-2018 TOPB45_0647 64079e2ff1e856b2527c91a0434ff3ae 433 Pfam PF14535 AMP-binding enzyme C-terminal domain 338 431 2.4E-28 T 13-10-2018 IPR028154 AMP-dependent ligase, C-terminal TOPB45_0647 64079e2ff1e856b2527c91a0434ff3ae 433 Gene3D G3DSA:3.40.50.12780 1 329 1.1E-125 T 13-10-2018 TOPB45_1346 affcd000a83360001aabe64b98a24fcd 123 Pfam PF01242 6-pyruvoyl tetrahydropterin synthase 4 122 8.9E-38 T 13-10-2018 IPR007115 6-pyruvoyl tetrahydropterin synthase/QueD family Reactome: R-HSA-1474151 TOPB45_1346 affcd000a83360001aabe64b98a24fcd 123 Gene3D G3DSA:3.30.479.10 1 123 1.2E-36 T 13-10-2018 IPR038418 6-pyruvoyl tetrahydropterin synthase/QueD superfamily Reactome: R-HSA-1474151 TOPB45_1346 affcd000a83360001aabe64b98a24fcd 123 TIGRFAM TIGR03367 queuosine_QueD: queuosine biosynthesis protein QueD 4 95 6.5E-29 T 13-10-2018 IPR007115 6-pyruvoyl tetrahydropterin synthase/QueD family Reactome: R-HSA-1474151 TOPB45_1346 affcd000a83360001aabe64b98a24fcd 123 SUPERFAMILY SSF55620 1 122 4.67E-38 T 13-10-2018 TOPB45_1346 affcd000a83360001aabe64b98a24fcd 123 PIRSF PIRSF006113 2 123 1.9E-28 T 13-10-2018 IPR007115 6-pyruvoyl tetrahydropterin synthase/QueD family Reactome: R-HSA-1474151 TOPB45_0445 eff2f39ac77ac7f050acf6920e4dd533 474 SMART SM00028 328 361 7.3 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_0445 eff2f39ac77ac7f050acf6920e4dd533 474 SMART SM00028 423 456 1.7 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_0445 eff2f39ac77ac7f050acf6920e4dd533 474 SUPERFAMILY SSF48452 292 468 1.1E-12 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_0445 eff2f39ac77ac7f050acf6920e4dd533 474 Gene3D G3DSA:1.25.40.10 240 471 1.2E-12 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_0445 eff2f39ac77ac7f050acf6920e4dd533 474 Pfam PF01435 Peptidase family M48 72 239 6.8E-25 T 13-10-2018 IPR001915 Peptidase M48 GO:0004222|GO:0006508 TOPB45_0768 703cdbbd7cdbbd237efaed263e380ff8 194 SUPERFAMILY SSF56053 91 189 3.17E-32 T 13-10-2018 IPR036789 Ribosomal protein L6, alpha-beta domain superfamily GO:0003735|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0768 703cdbbd7cdbbd237efaed263e380ff8 194 Hamap MF_01365_B 50S ribosomal protein L6 [rplF]. 4 189 36.893 T 13-10-2018 IPR019906 Ribosomal protein L6, bacterial-type GO:0003735|GO:0005840|GO:0006412|GO:0019843 TOPB45_0768 703cdbbd7cdbbd237efaed263e380ff8 194 Gene3D G3DSA:3.90.930.12 91 193 7.2E-38 T 13-10-2018 IPR036789 Ribosomal protein L6, alpha-beta domain superfamily GO:0003735|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0768 703cdbbd7cdbbd237efaed263e380ff8 194 ProSitePatterns PS00525 Ribosomal protein L6 signature 1. 167 175 - T 13-10-2018 IPR002358 Ribosomal protein L6, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0768 703cdbbd7cdbbd237efaed263e380ff8 194 SUPERFAMILY SSF56053 5 90 1.8E-20 T 13-10-2018 IPR036789 Ribosomal protein L6, alpha-beta domain superfamily GO:0003735|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0768 703cdbbd7cdbbd237efaed263e380ff8 194 PRINTS PR00059 Ribosomal protein L6 signature 79 104 1.7E-25 T 13-10-2018 IPR019906 Ribosomal protein L6, bacterial-type GO:0003735|GO:0005840|GO:0006412|GO:0019843 TOPB45_0768 703cdbbd7cdbbd237efaed263e380ff8 194 PRINTS PR00059 Ribosomal protein L6 signature 154 175 1.7E-25 T 13-10-2018 IPR019906 Ribosomal protein L6, bacterial-type GO:0003735|GO:0005840|GO:0006412|GO:0019843 TOPB45_0768 703cdbbd7cdbbd237efaed263e380ff8 194 Pfam PF00347 Ribosomal protein L6 14 90 5.2E-16 T 13-10-2018 IPR020040 Ribosomal protein L6, alpha-beta domain GO:0003735|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0768 703cdbbd7cdbbd237efaed263e380ff8 194 Pfam PF00347 Ribosomal protein L6 98 177 1.4E-17 T 13-10-2018 IPR020040 Ribosomal protein L6, alpha-beta domain GO:0003735|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0768 703cdbbd7cdbbd237efaed263e380ff8 194 TIGRFAM TIGR03654 L6_bact: ribosomal protein uL6 5 189 1.2E-67 T 13-10-2018 IPR019906 Ribosomal protein L6, bacterial-type GO:0003735|GO:0005840|GO:0006412|GO:0019843 TOPB45_0768 703cdbbd7cdbbd237efaed263e380ff8 194 PIRSF PIRSF002162 3 190 3.8E-52 T 13-10-2018 IPR000702 Ribosomal protein L6 GO:0003735|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0768 703cdbbd7cdbbd237efaed263e380ff8 194 Gene3D G3DSA:3.90.930.12 4 90 6.6E-27 T 13-10-2018 IPR036789 Ribosomal protein L6, alpha-beta domain superfamily GO:0003735|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0573 4f819904c4e222ec2cae349f50061bb6 283 Gene3D G3DSA:3.40.50.150 85 280 2.5E-47 T 13-10-2018 TOPB45_0573 4f819904c4e222ec2cae349f50061bb6 283 Pfam PF06325 Ribosomal protein L11 methyltransferase (PrmA) 30 276 4.3E-61 T 13-10-2018 TOPB45_0573 4f819904c4e222ec2cae349f50061bb6 283 PIRSF PIRSF000401 9 282 1.7E-58 T 13-10-2018 IPR004498 Ribosomal protein L11 methyltransferase GO:0006479|GO:0008276 TOPB45_0573 4f819904c4e222ec2cae349f50061bb6 283 SUPERFAMILY SSF53335 29 278 2.54E-34 T 13-10-2018 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TOPB45_0573 4f819904c4e222ec2cae349f50061bb6 283 Hamap MF_00735 Ribosomal protein L11 methyltransferase [prmA]. 5 280 27.293 T 13-10-2018 IPR004498 Ribosomal protein L11 methyltransferase GO:0006479|GO:0008276 TOPB45_1111 8afa069ee9820b478b2c093142336a37 286 TIGRFAM TIGR02582 cas7_TM1809: CRISPR type III-A/MTUBE-associated RAMP protein Csm3 6 243 2.1E-60 T 13-10-2018 IPR013412 CRISPR-associated RAMP Csm3 TOPB45_1111 8afa069ee9820b478b2c093142336a37 286 Pfam PF03787 RAMP superfamily 13 242 9.8E-16 T 13-10-2018 IPR005537 CRISPR type III-associated RAMP protein TOPB45_1534 e54c4a7973bce0641994728f6965c46b 194 Pfam PF01025 GrpE 11 172 4.5E-48 T 13-10-2018 IPR000740 GrpE nucleotide exchange factor GO:0000774|GO:0006457|GO:0042803|GO:0051087 Reactome: R-HSA-1268020 TOPB45_1534 e54c4a7973bce0641994728f6965c46b 194 Gene3D G3DSA:3.90.20.20 8 115 5.1E-24 T 13-10-2018 IPR013805 GrpE nucleotide exchange factor, coiled-coil Reactome: R-HSA-1268020 TOPB45_1534 e54c4a7973bce0641994728f6965c46b 194 SUPERFAMILY SSF58014 23 116 6.15E-23 T 13-10-2018 IPR013805 GrpE nucleotide exchange factor, coiled-coil Reactome: R-HSA-1268020 TOPB45_1534 e54c4a7973bce0641994728f6965c46b 194 SUPERFAMILY SSF51064 121 174 6.41E-15 T 13-10-2018 IPR009012 GrpE nucleotide exchange factor, head GO:0006457 Reactome: R-HSA-1268020 TOPB45_1534 e54c4a7973bce0641994728f6965c46b 194 Hamap MF_01151 Protein GrpE [grpE]. 2 173 19.448 T 13-10-2018 IPR000740 GrpE nucleotide exchange factor GO:0000774|GO:0006457|GO:0042803|GO:0051087 Reactome: R-HSA-1268020 TOPB45_1534 e54c4a7973bce0641994728f6965c46b 194 Gene3D G3DSA:2.30.22.10 116 182 3.2E-16 T 13-10-2018 IPR009012 GrpE nucleotide exchange factor, head GO:0006457 Reactome: R-HSA-1268020 TOPB45_1534 e54c4a7973bce0641994728f6965c46b 194 PRINTS PR00773 GrpE protein signature 42 58 1.1E-25 T 13-10-2018 IPR000740 GrpE nucleotide exchange factor GO:0000774|GO:0006457|GO:0042803|GO:0051087 Reactome: R-HSA-1268020 TOPB45_1534 e54c4a7973bce0641994728f6965c46b 194 PRINTS PR00773 GrpE protein signature 152 171 1.1E-25 T 13-10-2018 IPR000740 GrpE nucleotide exchange factor GO:0000774|GO:0006457|GO:0042803|GO:0051087 Reactome: R-HSA-1268020 TOPB45_1534 e54c4a7973bce0641994728f6965c46b 194 PRINTS PR00773 GrpE protein signature 125 140 1.1E-25 T 13-10-2018 IPR000740 GrpE nucleotide exchange factor GO:0000774|GO:0006457|GO:0042803|GO:0051087 Reactome: R-HSA-1268020 TOPB45_1534 e54c4a7973bce0641994728f6965c46b 194 PRINTS PR00773 GrpE protein signature 70 85 1.1E-25 T 13-10-2018 IPR000740 GrpE nucleotide exchange factor GO:0000774|GO:0006457|GO:0042803|GO:0051087 Reactome: R-HSA-1268020 TOPB45_0498 ed6cc99dc9a0909e8649abf4c058cf1f 238 SUPERFAMILY SSF54862 2 172 2.2E-61 T 13-10-2018 TOPB45_0498 ed6cc99dc9a0909e8649abf4c058cf1f 238 Pfam PF12800 4Fe-4S binding domain 10 25 0.026 T 13-10-2018 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain TOPB45_0498 ed6cc99dc9a0909e8649abf4c058cf1f 238 Gene3D G3DSA:3.30.70.20 6 171 4.5E-65 T 13-10-2018 TOPB45_0498 ed6cc99dc9a0909e8649abf4c058cf1f 238 Pfam PF13247 4Fe-4S dicluster domain 65 162 3.7E-32 T 13-10-2018 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain TOPB45_0498 ed6cc99dc9a0909e8649abf4c058cf1f 238 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 107 118 - T 13-10-2018 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site TOPB45_0498 ed6cc99dc9a0909e8649abf4c058cf1f 238 Gene3D G3DSA:3.30.70.20 76 134 4.5E-65 T 13-10-2018 TOPB45_1000 f0b5833957e58b3aa7a2bc90377c9886 201 Pfam PF02635 DsrE/DsrF-like family 129 175 6.6E-5 T 13-10-2018 IPR003787 Sulphur relay, DsrE/F-like protein TOPB45_1000 f0b5833957e58b3aa7a2bc90377c9886 201 Pfam PF01206 Sulfurtransferase TusA 2 71 3.1E-22 T 13-10-2018 IPR001455 TusA-like domain TOPB45_1000 f0b5833957e58b3aa7a2bc90377c9886 201 Gene3D G3DSA:3.30.110.40 2 86 5.6E-23 T 13-10-2018 IPR036868 TusA-like domain superfamily TOPB45_1000 f0b5833957e58b3aa7a2bc90377c9886 201 ProSitePatterns PS01148 Uncharacterized protein family UPF0033 signature. 4 28 - T 13-10-2018 IPR001455 TusA-like domain TOPB45_1000 f0b5833957e58b3aa7a2bc90377c9886 201 SUPERFAMILY SSF64307 1 71 1.44E-20 T 13-10-2018 IPR036868 TusA-like domain superfamily TOPB45_1000 f0b5833957e58b3aa7a2bc90377c9886 201 TIGRFAM TIGR03527 selenium_YedF: selenium metabolism protein YedF 4 200 8.6E-63 T 13-10-2018 IPR019870 Selenium metabolism protein YedF TOPB45_1000 f0b5833957e58b3aa7a2bc90377c9886 201 SUPERFAMILY SSF75169 120 176 4.71E-9 T 13-10-2018 IPR027396 DsrEFH-like TOPB45_1366 25b79d91d69f69483a2fc3bdb37dbdda 273 PIRSF PIRSF004793 9 264 2.2E-85 T 13-10-2018 IPR014046 Diadenylate cyclase GO:0004016|GO:0006171 TOPB45_1366 25b79d91d69f69483a2fc3bdb37dbdda 273 Gene3D G3DSA:3.40.1700.10 103 254 4.0E-60 T 13-10-2018 IPR036888 DNA integrity scanning protein, DisA, N-terminal domain superfamily TOPB45_1366 25b79d91d69f69483a2fc3bdb37dbdda 273 SUPERFAMILY SSF143597 46 240 1.96E-65 T 13-10-2018 IPR036888 DNA integrity scanning protein, DisA, N-terminal domain superfamily TOPB45_1366 25b79d91d69f69483a2fc3bdb37dbdda 273 Hamap MF_01499 Diadenylate cyclase [dacA]. 14 254 33.857 T 13-10-2018 IPR034701 Diadenylate cyclase CdaA GO:0004016|GO:0006171 TOPB45_1366 25b79d91d69f69483a2fc3bdb37dbdda 273 TIGRFAM TIGR00159 TIGR00159: TIGR00159 family protein 16 249 1.1E-73 T 13-10-2018 IPR034701 Diadenylate cyclase CdaA GO:0004016|GO:0006171 TOPB45_1366 25b79d91d69f69483a2fc3bdb37dbdda 273 Pfam PF02457 DisA bacterial checkpoint controller nucleotide-binding 118 236 7.6E-44 T 13-10-2018 IPR003390 DNA integrity scanning protein, DisA, N-terminal TOPB45_0013 22b30c96a554eeb24a5485e504b84c35 128 Gene3D G3DSA:3.90.470.20 1 124 2.9E-33 T 13-10-2018 IPR037143 4'-phosphopantetheinyl transferase domain superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1|MetaCyc: PWY-6289|Reactome: R-HSA-199220 TOPB45_0013 22b30c96a554eeb24a5485e504b84c35 128 SUPERFAMILY SSF56214 4 122 1.28E-21 T 13-10-2018 IPR037143 4'-phosphopantetheinyl transferase domain superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1|MetaCyc: PWY-6289|Reactome: R-HSA-199220 TOPB45_0013 22b30c96a554eeb24a5485e504b84c35 128 ProDom PD004282 TRANSFERASE SYNTHASE HOLO-ACYL-CARRIER-PROTEIN HOLO-ACP 4'-PHOSPHOPANTETHEINYL FATTY ACID METAL-BINDING MAGNESIUM LIPID 9 123 6.0E-16 T 13-10-2018 IPR004568 Phosphopantetheine-protein transferase domain GO:0000287|GO:0006633|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1|MetaCyc: PWY-6289 TOPB45_0013 22b30c96a554eeb24a5485e504b84c35 128 Hamap MF_00101 Holo-[acyl-carrier-protein] synthase [acpS]. 4 125 20.845 T 13-10-2018 IPR002582 Holo-[acyl carrier protein] synthase GO:0000287|GO:0006633|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1|MetaCyc: PWY-6289 TOPB45_0013 22b30c96a554eeb24a5485e504b84c35 128 TIGRFAM TIGR00556 pantethn_trn: phosphopantetheine--protein transferase domain 4 123 1.7E-20 T 13-10-2018 IPR004568 Phosphopantetheine-protein transferase domain GO:0000287|GO:0006633|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1|MetaCyc: PWY-6289 TOPB45_0013 22b30c96a554eeb24a5485e504b84c35 128 TIGRFAM TIGR00516 acpS: holo-[acyl-carrier-protein] synthase 4 123 7.0E-19 T 13-10-2018 IPR002582 Holo-[acyl carrier protein] synthase GO:0000287|GO:0006633|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1|MetaCyc: PWY-6289 TOPB45_0013 22b30c96a554eeb24a5485e504b84c35 128 Pfam PF01648 4'-phosphopantetheinyl transferase superfamily 5 121 3.1E-17 T 13-10-2018 IPR008278 4'-phosphopantetheinyl transferase domain GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1|MetaCyc: PWY-6289|Reactome: R-HSA-199220 TOPB45_1216 f9aa9386525a6e0b5a7039a9eb8e9fe3 395 Gene3D G3DSA:3.40.640.10 69 299 2.0E-132 T 13-10-2018 IPR015421 Pyridoxal phosphate-dependent transferase, major domain GO:0003824 TOPB45_1216 f9aa9386525a6e0b5a7039a9eb8e9fe3 395 SUPERFAMILY SSF53383 26 380 4.08E-87 T 13-10-2018 IPR015424 Pyridoxal phosphate-dependent transferase TOPB45_1216 f9aa9386525a6e0b5a7039a9eb8e9fe3 395 Pfam PF00155 Aminotransferase class I and II 35 377 6.7E-55 T 13-10-2018 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 TOPB45_1216 f9aa9386525a6e0b5a7039a9eb8e9fe3 395 ProSitePatterns PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 241 254 - T 13-10-2018 IPR004838 Aminotransferases, class-I, pyridoxal-phosphate-binding site GO:0003824|GO:0009058|GO:0030170 TOPB45_1216 f9aa9386525a6e0b5a7039a9eb8e9fe3 395 Gene3D G3DSA:3.90.1150.10 16 375 2.0E-132 T 13-10-2018 IPR015422 Pyridoxal phosphate-dependent transferase domain 1 GO:0003824 TOPB45_0075 f967037c4b6a347c56127d0ce0ee3cb8 315 Pfam PF14572 Phosphoribosyl synthetase-associated domain 200 314 4.2E-30 T 13-10-2018 IPR005946 Ribose-phosphate pyrophosphokinase GO:0000287|GO:0004749|GO:0009165 KEGG: 00030+2.7.6.1|KEGG: 00230+2.7.6.1 TOPB45_0075 f967037c4b6a347c56127d0ce0ee3cb8 315 SMART SM01400 6 122 2.2E-86 T 13-10-2018 TOPB45_0075 f967037c4b6a347c56127d0ce0ee3cb8 315 Pfam PF13793 N-terminal domain of ribose phosphate pyrophosphokinase 7 122 3.7E-52 T 13-10-2018 IPR029099 Ribose-phosphate pyrophosphokinase, N-terminal domain KEGG: 00030+2.7.6.1|KEGG: 00230+2.7.6.1 TOPB45_0075 f967037c4b6a347c56127d0ce0ee3cb8 315 SUPERFAMILY SSF53271 71 306 4.77E-64 T 13-10-2018 IPR029057 Phosphoribosyltransferase-like TOPB45_0075 f967037c4b6a347c56127d0ce0ee3cb8 315 TIGRFAM TIGR01251 ribP_PPkin: ribose-phosphate diphosphokinase 7 314 3.2E-124 T 13-10-2018 IPR005946 Ribose-phosphate pyrophosphokinase GO:0000287|GO:0004749|GO:0009165 KEGG: 00030+2.7.6.1|KEGG: 00230+2.7.6.1 TOPB45_0075 f967037c4b6a347c56127d0ce0ee3cb8 315 Gene3D G3DSA:3.40.50.2020 9 303 7.9E-132 T 13-10-2018 TOPB45_0075 f967037c4b6a347c56127d0ce0ee3cb8 315 ProSitePatterns PS00114 Phosphoribosyl pyrophosphate synthase signature. 130 145 - T 13-10-2018 IPR000842 Phosphoribosyl pyrophosphate synthetase, conserved site GO:0000287|GO:0004749|GO:0009156|GO:0044249 KEGG: 00030+2.7.6.1|KEGG: 00230+2.7.6.1|Reactome: R-HSA-73843 TOPB45_0075 f967037c4b6a347c56127d0ce0ee3cb8 315 Gene3D G3DSA:3.40.50.2020 149 291 7.9E-132 T 13-10-2018 TOPB45_0075 f967037c4b6a347c56127d0ce0ee3cb8 315 Hamap MF_00583_B Putative ribose-phosphate pyrophosphokinase [prs]. 6 315 49.835 T 13-10-2018 IPR037515 Ribose-phosphate pyrophosphokinase, bacterial-type GO:0004749 KEGG: 00030+2.7.6.1|KEGG: 00230+2.7.6.1|Reactome: R-HSA-73843 TOPB45_1172 4a38b60afa0d5f88259acb92bda32e11 205 Pfam PF00625 Guanylate kinase 9 184 1.1E-51 T 13-10-2018 IPR008145 Guanylate kinase/L-type calcium channel beta subunit TOPB45_1172 4a38b60afa0d5f88259acb92bda32e11 205 ProSitePatterns PS00856 Guanylate kinase-like signature. 38 55 - T 13-10-2018 IPR020590 Guanylate kinase, conserved site KEGG: 00230+2.7.4.8|MetaCyc: PWY-7221 TOPB45_1172 4a38b60afa0d5f88259acb92bda32e11 205 SUPERFAMILY SSF52540 3 189 5.17E-66 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1172 4a38b60afa0d5f88259acb92bda32e11 205 Hamap MF_00328 Guanylate kinase [gmk]. 4 186 35.138 T 13-10-2018 IPR017665 Guanylate kinase GO:0004385|GO:0006163 KEGG: 00230+2.7.4.8|MetaCyc: PWY-7221|Reactome: R-HSA-2161541|Reactome: R-HSA-499943 TOPB45_1172 4a38b60afa0d5f88259acb92bda32e11 205 Gene3D G3DSA:3.40.50.300 10 182 4.1E-65 T 13-10-2018 TOPB45_1172 4a38b60afa0d5f88259acb92bda32e11 205 SMART SM00072 5 186 3.5E-63 T 13-10-2018 IPR008145 Guanylate kinase/L-type calcium channel beta subunit TOPB45_1172 4a38b60afa0d5f88259acb92bda32e11 205 TIGRFAM TIGR03263 guanyl_kin: guanylate kinase 8 183 1.5E-67 T 13-10-2018 IPR017665 Guanylate kinase GO:0004385|GO:0006163 KEGG: 00230+2.7.4.8|MetaCyc: PWY-7221|Reactome: R-HSA-2161541|Reactome: R-HSA-499943 TOPB45_1172 4a38b60afa0d5f88259acb92bda32e11 205 Gene3D G3DSA:3.30.63.10 35 94 4.1E-65 T 13-10-2018 TOPB45_1360 8527dfb5519744754da5eb86512c6774 202 Hamap MF_01043 Glycerol-3-phosphate acyltransferase [plsY]. 6 198 19.892 T 13-10-2018 IPR003811 Glycerol-3-phosphate acyltransferase, PlsY GO:0005886|GO:0008654|GO:0043772 TOPB45_1360 8527dfb5519744754da5eb86512c6774 202 TIGRFAM TIGR00023 TIGR00023: acyl-phosphate glycerol 3-phosphate acyltransferase 5 195 1.1E-54 T 13-10-2018 IPR003811 Glycerol-3-phosphate acyltransferase, PlsY GO:0005886|GO:0008654|GO:0043772 TOPB45_1360 8527dfb5519744754da5eb86512c6774 202 SMART SM01207 9 190 3.5E-80 T 13-10-2018 IPR003811 Glycerol-3-phosphate acyltransferase, PlsY GO:0005886|GO:0008654|GO:0043772 TOPB45_1360 8527dfb5519744754da5eb86512c6774 202 Pfam PF02660 Glycerol-3-phosphate acyltransferase 10 189 1.7E-54 T 13-10-2018 IPR003811 Glycerol-3-phosphate acyltransferase, PlsY GO:0005886|GO:0008654|GO:0043772 TOPB45_1485 dee17442bf5b981a023b2f15c14549ff 373 Pfam PF02767 DNA polymerase III beta subunit, central domain 132 250 4.7E-15 T 13-10-2018 IPR022637 DNA polymerase III, beta sliding clamp, central GO:0003887|GO:0006260|GO:0008408|GO:0009360 TOPB45_1485 dee17442bf5b981a023b2f15c14549ff 373 PIRSF PIRSF000804 1 373 2.0E-91 T 13-10-2018 IPR001001 DNA polymerase III, beta sliding clamp GO:0003677|GO:0006260|GO:0009360 TOPB45_1485 dee17442bf5b981a023b2f15c14549ff 373 Gene3D G3DSA:3.10.150.10 1 249 1.5E-95 T 13-10-2018 TOPB45_1485 dee17442bf5b981a023b2f15c14549ff 373 SUPERFAMILY SSF55979 252 371 2.42E-31 T 13-10-2018 TOPB45_1485 dee17442bf5b981a023b2f15c14549ff 373 TIGRFAM TIGR00663 dnan: DNA polymerase III, beta subunit 2 371 2.6E-77 T 13-10-2018 IPR001001 DNA polymerase III, beta sliding clamp GO:0003677|GO:0006260|GO:0009360 TOPB45_1485 dee17442bf5b981a023b2f15c14549ff 373 Pfam PF00712 DNA polymerase III beta subunit, N-terminal domain 1 123 2.0E-17 T 13-10-2018 IPR022634 DNA polymerase III, beta sliding clamp, N-terminal GO:0003677|GO:0003887|GO:0006260|GO:0008408|GO:0009360 TOPB45_1485 dee17442bf5b981a023b2f15c14549ff 373 Pfam PF02768 DNA polymerase III beta subunit, C-terminal domain 252 371 1.8E-25 T 13-10-2018 IPR022635 DNA polymerase III, beta sliding clamp, C-terminal GO:0003677|GO:0003887|GO:0006260|GO:0008408|GO:0009360 TOPB45_1485 dee17442bf5b981a023b2f15c14549ff 373 SMART SM00480 17 369 1.2E-70 T 13-10-2018 IPR001001 DNA polymerase III, beta sliding clamp GO:0003677|GO:0006260|GO:0009360 TOPB45_1485 dee17442bf5b981a023b2f15c14549ff 373 Gene3D G3DSA:3.70.10.10 141 371 1.5E-95 T 13-10-2018 TOPB45_1485 dee17442bf5b981a023b2f15c14549ff 373 SUPERFAMILY SSF55979 1 123 6.28E-18 T 13-10-2018 TOPB45_1485 dee17442bf5b981a023b2f15c14549ff 373 SUPERFAMILY SSF55979 130 251 1.95E-15 T 13-10-2018 TOPB45_1304 1d562bac319542af6d89ef1d386219fd 432 Gene3D G3DSA:3.40.50.1980 32 236 1.3E-119 T 13-10-2018 TOPB45_1304 1d562bac319542af6d89ef1d386219fd 432 Hamap MF_01024 Histidinol dehydrogenase [hisD]. 6 432 40.982 T 13-10-2018 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23 TOPB45_1304 1d562bac319542af6d89ef1d386219fd 432 PRINTS PR00083 Histidinol dehydrogenase signature 325 350 2.0E-86 T 13-10-2018 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23 TOPB45_1304 1d562bac319542af6d89ef1d386219fd 432 PRINTS PR00083 Histidinol dehydrogenase signature 366 384 2.0E-86 T 13-10-2018 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23 TOPB45_1304 1d562bac319542af6d89ef1d386219fd 432 PRINTS PR00083 Histidinol dehydrogenase signature 256 275 2.0E-86 T 13-10-2018 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23 TOPB45_1304 1d562bac319542af6d89ef1d386219fd 432 PRINTS PR00083 Histidinol dehydrogenase signature 205 230 2.0E-86 T 13-10-2018 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23 TOPB45_1304 1d562bac319542af6d89ef1d386219fd 432 PRINTS PR00083 Histidinol dehydrogenase signature 175 201 2.0E-86 T 13-10-2018 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23 TOPB45_1304 1d562bac319542af6d89ef1d386219fd 432 PRINTS PR00083 Histidinol dehydrogenase signature 140 166 2.0E-86 T 13-10-2018 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23 TOPB45_1304 1d562bac319542af6d89ef1d386219fd 432 PRINTS PR00083 Histidinol dehydrogenase signature 35 59 2.0E-86 T 13-10-2018 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23 TOPB45_1304 1d562bac319542af6d89ef1d386219fd 432 PRINTS PR00083 Histidinol dehydrogenase signature 234 255 2.0E-86 T 13-10-2018 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23 TOPB45_1304 1d562bac319542af6d89ef1d386219fd 432 Pfam PF00815 Histidinol dehydrogenase 25 432 7.6E-160 T 13-10-2018 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23 TOPB45_1304 1d562bac319542af6d89ef1d386219fd 432 PIRSF PIRSF000099 1 432 9.1E-162 T 13-10-2018 IPR022695 Histidinol dehydrogenase, monofunctional GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23 TOPB45_1304 1d562bac319542af6d89ef1d386219fd 432 TIGRFAM TIGR00069 hisD: histidinol dehydrogenase 35 431 6.7E-157 T 13-10-2018 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23 TOPB45_1304 1d562bac319542af6d89ef1d386219fd 432 SUPERFAMILY SSF53720 29 431 2.55E-70 T 13-10-2018 IPR016161 Aldehyde/histidinol dehydrogenase GO:0016491|GO:0055114 TOPB45_1304 1d562bac319542af6d89ef1d386219fd 432 ProSitePatterns PS00611 Histidinol dehydrogenase signature. 234 266 - T 13-10-2018 IPR001692 Histidinol dehydrogenase, conserved site GO:0000105|GO:0004399|GO:0055114 KEGG: 00340+1.1.1.23 TOPB45_1304 1d562bac319542af6d89ef1d386219fd 432 Gene3D G3DSA:3.40.50.1980 238 354 1.3E-119 T 13-10-2018 TOPB45_0295 c605ad402730bde683f39184a8dc049f 325 SUPERFAMILY SSF51569 2 324 2.05E-151 T 13-10-2018 TOPB45_0295 c605ad402730bde683f39184a8dc049f 325 ProSitePatterns PS00169 Delta-aminolevulinic acid dehydratase active site. 241 253 - T 13-10-2018 IPR030656 Delta-aminolevulinic acid dehydratase, active site KEGG: 00860+4.2.1.24|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451|Reactome: R-HSA-6798695 TOPB45_0295 c605ad402730bde683f39184a8dc049f 325 PRINTS PR00144 Delta-aminolevulinic acid dehydratase signature 296 315 8.0E-62 T 13-10-2018 IPR001731 Delta-aminolevulinic acid dehydratase GO:0004655|GO:0033014|GO:0046872 KEGG: 00860+4.2.1.24|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451|Reactome: R-HSA-6798695 TOPB45_0295 c605ad402730bde683f39184a8dc049f 325 PRINTS PR00144 Delta-aminolevulinic acid dehydratase signature 241 257 8.0E-62 T 13-10-2018 IPR001731 Delta-aminolevulinic acid dehydratase GO:0004655|GO:0033014|GO:0046872 KEGG: 00860+4.2.1.24|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451|Reactome: R-HSA-6798695 TOPB45_0295 c605ad402730bde683f39184a8dc049f 325 PRINTS PR00144 Delta-aminolevulinic acid dehydratase signature 121 135 8.0E-62 T 13-10-2018 IPR001731 Delta-aminolevulinic acid dehydratase GO:0004655|GO:0033014|GO:0046872 KEGG: 00860+4.2.1.24|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451|Reactome: R-HSA-6798695 TOPB45_0295 c605ad402730bde683f39184a8dc049f 325 PRINTS PR00144 Delta-aminolevulinic acid dehydratase signature 151 170 8.0E-62 T 13-10-2018 IPR001731 Delta-aminolevulinic acid dehydratase GO:0004655|GO:0033014|GO:0046872 KEGG: 00860+4.2.1.24|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451|Reactome: R-HSA-6798695 TOPB45_0295 c605ad402730bde683f39184a8dc049f 325 PRINTS PR00144 Delta-aminolevulinic acid dehydratase signature 266 281 8.0E-62 T 13-10-2018 IPR001731 Delta-aminolevulinic acid dehydratase GO:0004655|GO:0033014|GO:0046872 KEGG: 00860+4.2.1.24|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451|Reactome: R-HSA-6798695 TOPB45_0295 c605ad402730bde683f39184a8dc049f 325 PRINTS PR00144 Delta-aminolevulinic acid dehydratase signature 189 208 8.0E-62 T 13-10-2018 IPR001731 Delta-aminolevulinic acid dehydratase GO:0004655|GO:0033014|GO:0046872 KEGG: 00860+4.2.1.24|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451|Reactome: R-HSA-6798695 TOPB45_0295 c605ad402730bde683f39184a8dc049f 325 Gene3D G3DSA:3.20.20.70 1 323 5.4E-161 T 13-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 TOPB45_0295 c605ad402730bde683f39184a8dc049f 325 SMART SM01004 3 322 3.8E-256 T 13-10-2018 IPR001731 Delta-aminolevulinic acid dehydratase GO:0004655|GO:0033014|GO:0046872 KEGG: 00860+4.2.1.24|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451|Reactome: R-HSA-6798695 TOPB45_0295 c605ad402730bde683f39184a8dc049f 325 Pfam PF00490 Delta-aminolevulinic acid dehydratase 6 320 1.0E-160 T 13-10-2018 IPR001731 Delta-aminolevulinic acid dehydratase GO:0004655|GO:0033014|GO:0046872 KEGG: 00860+4.2.1.24|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451|Reactome: R-HSA-6798695 TOPB45_0295 c605ad402730bde683f39184a8dc049f 325 PIRSF PIRSF001415 1 325 1.4E-161 T 13-10-2018 IPR001731 Delta-aminolevulinic acid dehydratase GO:0004655|GO:0033014|GO:0046872 KEGG: 00860+4.2.1.24|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451|Reactome: R-HSA-6798695 TOPB45_0969 10ca8551d3bd6295562f36f963b8b4f5 428 Gene3D G3DSA:3.30.565.10 281 427 1.1E-33 T 13-10-2018 IPR036890 Histidine kinase/HSP90-like ATPase superfamily TOPB45_0969 10ca8551d3bd6295562f36f963b8b4f5 428 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 319 426 1.7E-18 T 13-10-2018 IPR003594 Histidine kinase/HSP90-like ATPase TOPB45_0969 10ca8551d3bd6295562f36f963b8b4f5 428 Pfam PF00512 His Kinase A (phospho-acceptor) domain 219 273 1.1E-9 T 13-10-2018 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TOPB45_0969 10ca8551d3bd6295562f36f963b8b4f5 428 SMART SM00387 318 428 7.9E-24 T 13-10-2018 IPR003594 Histidine kinase/HSP90-like ATPase TOPB45_0969 10ca8551d3bd6295562f36f963b8b4f5 428 SUPERFAMILY SSF47384 212 274 9.42E-11 T 13-10-2018 IPR036097 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily GO:0000155|GO:0007165 TOPB45_0969 10ca8551d3bd6295562f36f963b8b4f5 428 PRINTS PR00344 Bacterial sensor protein C-terminal signature 412 425 8.8E-10 T 13-10-2018 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TOPB45_0969 10ca8551d3bd6295562f36f963b8b4f5 428 PRINTS PR00344 Bacterial sensor protein C-terminal signature 377 387 8.8E-10 T 13-10-2018 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TOPB45_0969 10ca8551d3bd6295562f36f963b8b4f5 428 PRINTS PR00344 Bacterial sensor protein C-terminal signature 388 406 8.8E-10 T 13-10-2018 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TOPB45_0969 10ca8551d3bd6295562f36f963b8b4f5 428 PRINTS PR00344 Bacterial sensor protein C-terminal signature 359 373 8.8E-10 T 13-10-2018 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TOPB45_0969 10ca8551d3bd6295562f36f963b8b4f5 428 SUPERFAMILY SSF55874 277 425 5.24E-30 T 13-10-2018 IPR036890 Histidine kinase/HSP90-like ATPase superfamily TOPB45_0969 10ca8551d3bd6295562f36f963b8b4f5 428 SMART SM00388 215 279 1.6E-9 T 13-10-2018 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TOPB45_0969 10ca8551d3bd6295562f36f963b8b4f5 428 Gene3D G3DSA:1.10.287.130 200 276 2.7E-12 T 13-10-2018 TOPB45_1247 19a7a035c652a370f4876f08e89f1441 468 SUPERFAMILY SSF55874 311 464 4.45E-43 T 13-10-2018 IPR036890 Histidine kinase/HSP90-like ATPase superfamily TOPB45_1247 19a7a035c652a370f4876f08e89f1441 468 Pfam PF00512 His Kinase A (phospho-acceptor) domain 251 318 8.6E-11 T 13-10-2018 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TOPB45_1247 19a7a035c652a370f4876f08e89f1441 468 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 359 465 1.5E-24 T 13-10-2018 IPR003594 Histidine kinase/HSP90-like ATPase TOPB45_1247 19a7a035c652a370f4876f08e89f1441 468 Gene3D G3DSA:1.20.1480.50 149 244 2.6E-8 T 13-10-2018 TOPB45_1247 19a7a035c652a370f4876f08e89f1441 468 SMART SM00304 188 240 0.0057 T 13-10-2018 IPR003660 HAMP domain GO:0007165|GO:0016021 TOPB45_1247 19a7a035c652a370f4876f08e89f1441 468 SUPERFAMILY SSF47384 245 318 2.16E-11 T 13-10-2018 IPR036097 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily GO:0000155|GO:0007165 TOPB45_1247 19a7a035c652a370f4876f08e89f1441 468 SMART SM00388 250 320 8.1E-8 T 13-10-2018 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TOPB45_1247 19a7a035c652a370f4876f08e89f1441 468 Gene3D G3DSA:1.10.287.130 245 317 1.6E-14 T 13-10-2018 TOPB45_1247 19a7a035c652a370f4876f08e89f1441 468 SMART SM00387 358 466 2.0E-33 T 13-10-2018 IPR003594 Histidine kinase/HSP90-like ATPase TOPB45_1247 19a7a035c652a370f4876f08e89f1441 468 Gene3D G3DSA:3.30.565.10 319 467 3.1E-46 T 13-10-2018 IPR036890 Histidine kinase/HSP90-like ATPase superfamily TOPB45_1247 19a7a035c652a370f4876f08e89f1441 468 PRINTS PR00344 Bacterial sensor protein C-terminal signature 395 409 1.1E-17 T 13-10-2018 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TOPB45_1247 19a7a035c652a370f4876f08e89f1441 468 PRINTS PR00344 Bacterial sensor protein C-terminal signature 413 423 1.1E-17 T 13-10-2018 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TOPB45_1247 19a7a035c652a370f4876f08e89f1441 468 PRINTS PR00344 Bacterial sensor protein C-terminal signature 426 444 1.1E-17 T 13-10-2018 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TOPB45_1247 19a7a035c652a370f4876f08e89f1441 468 PRINTS PR00344 Bacterial sensor protein C-terminal signature 450 463 1.1E-17 T 13-10-2018 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TOPB45_0354 dd09d5a4b9c5f50ef02de8a5da843861 185 SUPERFAMILY SSF51182 3 183 1.34E-78 T 13-10-2018 IPR011051 RmlC-like cupin domain superfamily TOPB45_0354 dd09d5a4b9c5f50ef02de8a5da843861 185 Gene3D G3DSA:2.60.120.10 3 182 9.8E-77 T 13-10-2018 IPR014710 RmlC-like jelly roll fold TOPB45_0354 dd09d5a4b9c5f50ef02de8a5da843861 185 Pfam PF00908 dTDP-4-dehydrorhamnose 3,5-epimerase 8 176 2.8E-75 T 13-10-2018 IPR000888 dTDP-4-dehydrorhamnose 3,5-epimerase-related GO:0008830 TOPB45_0354 dd09d5a4b9c5f50ef02de8a5da843861 185 TIGRFAM TIGR01221 rmlC: dTDP-4-dehydrorhamnose 3,5-epimerase 5 177 7.4E-81 T 13-10-2018 IPR000888 dTDP-4-dehydrorhamnose 3,5-epimerase-related GO:0008830 TOPB45_0354 dd09d5a4b9c5f50ef02de8a5da843861 185 ProDom PD001462 35-EPIMERASE DTDP-4-DEHYDRORHAMNOSE ISOMERASE RMLC EPIMERASE RELATED DTDP-6-DEOXY-D-GLUCOSE-35-EPIMERASE DTDP-4-KETO-6-DEOXY-D-GLUCOSE DTDP-4-KETO-6-DEOXYGLUCOSE-35-EPIMERASE DTDP-L-RHAMNOSE 3 176 1.0E-63 T 13-10-2018 IPR000888 dTDP-4-dehydrorhamnose 3,5-epimerase-related GO:0008830 TOPB45_0110 02c3437e2a9dc7b3359533d86979b57a 151 ProDom PD004488 SSRA-BINDING RNA-BINDING SMPB SMALL B TMRNA-BINDING SSRA 3D-STRUCTURE HOMOLOG BINDING 6 129 6.0E-40 T 13-10-2018 IPR000037 SsrA-binding protein GO:0003723 TOPB45_0110 02c3437e2a9dc7b3359533d86979b57a 151 SUPERFAMILY SSF74982 3 131 1.31E-48 T 13-10-2018 IPR023620 Small protein B TOPB45_0110 02c3437e2a9dc7b3359533d86979b57a 151 TIGRFAM TIGR00086 smpB: SsrA-binding protein 6 149 1.8E-56 T 13-10-2018 IPR000037 SsrA-binding protein GO:0003723 TOPB45_0110 02c3437e2a9dc7b3359533d86979b57a 151 ProSitePatterns PS01317 SsrA-binding protein. 24 36 - T 13-10-2018 IPR020081 SsrA-binding protein, conserved site TOPB45_0110 02c3437e2a9dc7b3359533d86979b57a 151 Hamap MF_00023 SsrA-binding protein [smpB]. 1 151 68.725 T 13-10-2018 IPR000037 SsrA-binding protein GO:0003723 TOPB45_0110 02c3437e2a9dc7b3359533d86979b57a 151 Pfam PF01668 SmpB protein 7 149 1.3E-60 T 13-10-2018 IPR000037 SsrA-binding protein GO:0003723 TOPB45_0110 02c3437e2a9dc7b3359533d86979b57a 151 Gene3D G3DSA:2.40.280.10 2 128 2.5E-50 T 13-10-2018 IPR023620 Small protein B TOPB45_1321 d089241e31e0daacea7862eed1fbd0a1 123 Gene3D G3DSA:3.40.50.12740 2 123 6.0E-41 T 13-10-2018 TOPB45_1321 d089241e31e0daacea7862eed1fbd0a1 123 SUPERFAMILY SSF52172 1 121 1.57E-39 T 13-10-2018 IPR011006 CheY-like superfamily TOPB45_1321 d089241e31e0daacea7862eed1fbd0a1 123 Pfam PF00072 Response regulator receiver domain 4 116 2.2E-29 T 13-10-2018 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TOPB45_1321 d089241e31e0daacea7862eed1fbd0a1 123 SMART SM00448 2 116 3.6E-36 T 13-10-2018 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TOPB45_1014 37f17df97e50fbb75afc11ce00a7572b 413 Gene3D G3DSA:2.30.42.10 100 186 2.2E-95 T 13-10-2018 TOPB45_1014 37f17df97e50fbb75afc11ce00a7572b 413 Pfam PF03572 Peptidase family S41 198 363 3.7E-54 T 13-10-2018 IPR005151 Tail specific protease GO:0006508|GO:0008236 Reactome: R-HSA-2187335|Reactome: R-HSA-2453902 TOPB45_1014 37f17df97e50fbb75afc11ce00a7572b 413 TIGRFAM TIGR00225 prc: C-terminal processing peptidase 54 380 1.0E-104 T 13-10-2018 IPR004447 C-terminal-processing peptidase S41A GO:0006508|GO:0008236 TOPB45_1014 37f17df97e50fbb75afc11ce00a7572b 413 Gene3D G3DSA:3.90.226.10 187 361 2.2E-95 T 13-10-2018 TOPB45_1014 37f17df97e50fbb75afc11ce00a7572b 413 SMART SM00245 171 364 1.5E-65 T 13-10-2018 IPR005151 Tail specific protease GO:0006508|GO:0008236 Reactome: R-HSA-2187335|Reactome: R-HSA-2453902 TOPB45_1014 37f17df97e50fbb75afc11ce00a7572b 413 Gene3D G3DSA:3.30.750.44 42 339 2.2E-95 T 13-10-2018 TOPB45_1014 37f17df97e50fbb75afc11ce00a7572b 413 Pfam PF13180 PDZ domain 101 173 3.1E-13 T 13-10-2018 IPR001478 PDZ domain GO:0005515 TOPB45_1014 37f17df97e50fbb75afc11ce00a7572b 413 SMART SM00228 100 171 1.8E-19 T 13-10-2018 IPR001478 PDZ domain GO:0005515 TOPB45_1014 37f17df97e50fbb75afc11ce00a7572b 413 SUPERFAMILY SSF52096 35 368 6.96E-77 T 13-10-2018 IPR029045 ClpP/crotonase-like domain superfamily TOPB45_1014 37f17df97e50fbb75afc11ce00a7572b 413 SUPERFAMILY SSF50156 88 174 8.07E-21 T 13-10-2018 IPR036034 PDZ superfamily GO:0005515 TOPB45_0795 56873321da036eb65865826067a0ef7c 763 SUPERFAMILY SSF48334 34 277 4.45E-17 T 13-10-2018 IPR036187 DNA mismatch repair protein MutS, core domain superfamily TOPB45_0795 56873321da036eb65865826067a0ef7c 763 Pfam PF00488 MutS domain V 325 503 3.6E-31 T 13-10-2018 IPR000432 DNA mismatch repair protein MutS, C-terminal GO:0005524|GO:0006298|GO:0030983 TOPB45_0795 56873321da036eb65865826067a0ef7c 763 SMART SM00533 8 307 2.8E-4 T 13-10-2018 IPR007696 DNA mismatch repair protein MutS, core GO:0005524|GO:0006298|GO:0030983 TOPB45_0795 56873321da036eb65865826067a0ef7c 763 Gene3D G3DSA:3.40.50.300 287 596 2.4E-68 T 13-10-2018 TOPB45_0795 56873321da036eb65865826067a0ef7c 763 SMART SM00534 321 505 3.3E-45 T 13-10-2018 IPR000432 DNA mismatch repair protein MutS, C-terminal GO:0005524|GO:0006298|GO:0030983 TOPB45_0795 56873321da036eb65865826067a0ef7c 763 PIRSF PIRSF005814 2 760 8.7E-178 T 13-10-2018 IPR005747 Endonuclease MutS2 GO:0004519|GO:0016887|GO:0030983|GO:0045910 TOPB45_0795 56873321da036eb65865826067a0ef7c 763 Pfam PF01713 Smr domain 687 759 1.6E-17 T 13-10-2018 IPR002625 Smr domain TOPB45_0795 56873321da036eb65865826067a0ef7c 763 SUPERFAMILY SSF52540 285 508 4.96E-31 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0795 56873321da036eb65865826067a0ef7c 763 SMART SM00463 682 760 9.5E-17 T 13-10-2018 IPR002625 Smr domain TOPB45_0795 56873321da036eb65865826067a0ef7c 763 SUPERFAMILY SSF160443 685 759 3.53E-9 T 13-10-2018 IPR036063 Smr domain superfamily TOPB45_0795 56873321da036eb65865826067a0ef7c 763 Gene3D G3DSA:3.30.1370.110 673 760 1.9E-21 T 13-10-2018 TOPB45_0795 56873321da036eb65865826067a0ef7c 763 Hamap MF_00092 Endonuclease MutS2 [mutS2]. 1 759 17.366 T 13-10-2018 IPR005747 Endonuclease MutS2 GO:0004519|GO:0016887|GO:0030983|GO:0045910 TOPB45_1499 38eb4279f62340ebc6c50b3d44d1b272 435 Pfam PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 316 419 6.7E-33 T 13-10-2018 IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-173599 TOPB45_1499 38eb4279f62340ebc6c50b3d44d1b272 435 SUPERFAMILY SSF48179 201 297 7.65E-34 T 13-10-2018 IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily GO:0055114 TOPB45_1499 38eb4279f62340ebc6c50b3d44d1b272 435 Gene3D G3DSA:3.40.50.720 1 199 1.0E-76 T 13-10-2018 TOPB45_1499 38eb4279f62340ebc6c50b3d44d1b272 435 Pfam PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 1 182 8.8E-67 T 13-10-2018 IPR001732 UDP-glucose/GDP-mannose dehydrogenase, N-terminal GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-173599 TOPB45_1499 38eb4279f62340ebc6c50b3d44d1b272 435 SMART SM00984 316 419 1.5E-47 T 13-10-2018 IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-173599 TOPB45_1499 38eb4279f62340ebc6c50b3d44d1b272 435 PIRSF PIRSF500134 1 435 8.0E-184 T 13-10-2018 IPR028357 UDP-glucose 6-dehydrogenase, bacterial type GO:0000271|GO:0003979 KEGG: 00040+1.1.1.22|KEGG: 00053+1.1.1.22|KEGG: 00520+1.1.1.22|MetaCyc: PWY-7346|MetaCyc: PWY-7820 TOPB45_1499 38eb4279f62340ebc6c50b3d44d1b272 435 SUPERFAMILY SSF51735 1 188 2.27E-52 T 13-10-2018 IPR036291 NAD(P)-binding domain superfamily TOPB45_1499 38eb4279f62340ebc6c50b3d44d1b272 435 Pfam PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 201 293 1.2E-39 T 13-10-2018 IPR014026 UDP-glucose/GDP-mannose dehydrogenase, dimerisation GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-173599 TOPB45_1499 38eb4279f62340ebc6c50b3d44d1b272 435 Gene3D G3DSA:1.20.5.100 200 231 4.1E-18 T 13-10-2018 TOPB45_1499 38eb4279f62340ebc6c50b3d44d1b272 435 SUPERFAMILY SSF52413 303 429 8.89E-38 T 13-10-2018 IPR036220 UDP-glucose/GDP-mannose dehydrogenase, C-terminal domain superfamily Reactome: R-HSA-173599 TOPB45_1499 38eb4279f62340ebc6c50b3d44d1b272 435 TIGRFAM TIGR03026 NDP-sugDHase: nucleotide sugar dehydrogenase 1 415 8.9E-149 T 13-10-2018 IPR017476 UDP-glucose/GDP-mannose dehydrogenase GO:0016616|GO:0055114 Reactome: R-HSA-173599 TOPB45_1499 38eb4279f62340ebc6c50b3d44d1b272 435 Gene3D G3DSA:3.40.50.720 232 435 6.3E-79 T 13-10-2018 TOPB45_1499 38eb4279f62340ebc6c50b3d44d1b272 435 PIRSF PIRSF000124 1 434 3.3E-153 T 13-10-2018 IPR017476 UDP-glucose/GDP-mannose dehydrogenase GO:0016616|GO:0055114 Reactome: R-HSA-173599 TOPB45_0130 65764c2ff0ebd46ea02c8e3620c0d86e 357 PRINTS PR00142 RecA protein signature 171 200 5.7E-81 T 13-10-2018 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 TOPB45_0130 65764c2ff0ebd46ea02c8e3620c0d86e 357 PRINTS PR00142 RecA protein signature 309 326 5.7E-81 T 13-10-2018 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 TOPB45_0130 65764c2ff0ebd46ea02c8e3620c0d86e 357 PRINTS PR00142 RecA protein signature 133 162 5.7E-81 T 13-10-2018 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 TOPB45_0130 65764c2ff0ebd46ea02c8e3620c0d86e 357 PRINTS PR00142 RecA protein signature 251 280 5.7E-81 T 13-10-2018 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 TOPB45_0130 65764c2ff0ebd46ea02c8e3620c0d86e 357 PRINTS PR00142 RecA protein signature 99 128 5.7E-81 T 13-10-2018 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 TOPB45_0130 65764c2ff0ebd46ea02c8e3620c0d86e 357 PRINTS PR00142 RecA protein signature 218 246 5.7E-81 T 13-10-2018 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 TOPB45_0130 65764c2ff0ebd46ea02c8e3620c0d86e 357 TIGRFAM TIGR02012 tigrfam_recA: protein RecA 9 336 8.4E-158 T 13-10-2018 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 TOPB45_0130 65764c2ff0ebd46ea02c8e3620c0d86e 357 ProSitePatterns PS00321 recA signature. 221 229 - T 13-10-2018 IPR020584 DNA recombination/repair protein RecA, conserved site GO:0003677|GO:0005524|GO:0006259|GO:0008094 TOPB45_0130 65764c2ff0ebd46ea02c8e3620c0d86e 357 SMART SM00382 63 236 2.3E-7 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_0130 65764c2ff0ebd46ea02c8e3620c0d86e 357 SUPERFAMILY SSF54752 276 338 5.36E-16 T 13-10-2018 IPR023400 DNA recombination and repair protein RecA, C-terminal TOPB45_0130 65764c2ff0ebd46ea02c8e3620c0d86e 357 Gene3D G3DSA:3.40.50.300 31 275 4.5E-80 T 13-10-2018 TOPB45_0130 65764c2ff0ebd46ea02c8e3620c0d86e 357 SUPERFAMILY SSF52540 10 275 9.24E-59 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0130 65764c2ff0ebd46ea02c8e3620c0d86e 357 Gene3D G3DSA:3.30.250.10 276 340 2.6E-22 T 13-10-2018 IPR023400 DNA recombination and repair protein RecA, C-terminal TOPB45_0130 65764c2ff0ebd46ea02c8e3620c0d86e 357 Pfam PF00154 recA bacterial DNA recombination protein 12 276 1.1E-130 T 13-10-2018 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 TOPB45_0130 65764c2ff0ebd46ea02c8e3620c0d86e 357 Hamap MF_00268 Protein RecA [recA]. 10 341 49.25 T 13-10-2018 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 TOPB45_0558 1e026358a46864ea6f191aaf4c7a78b3 321 Pfam PF00294 pfkB family carbohydrate kinase 64 307 1.6E-33 T 13-10-2018 IPR011611 Carbohydrate kinase PfkB TOPB45_0558 1e026358a46864ea6f191aaf4c7a78b3 321 SUPERFAMILY SSF53613 1 304 2.65E-44 T 13-10-2018 IPR029056 Ribokinase-like TOPB45_0558 1e026358a46864ea6f191aaf4c7a78b3 321 Gene3D G3DSA:3.40.1190.20 45 318 2.6E-54 T 13-10-2018 IPR029056 Ribokinase-like TOPB45_1186 562cdac37bb064d2d57d563c89068c6c 512 Gene3D G3DSA:3.40.50.620 5 328 2.4E-136 T 13-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TOPB45_1186 562cdac37bb064d2d57d563c89068c6c 512 SUPERFAMILY SSF47323 347 505 2.24E-37 T 13-10-2018 IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 TOPB45_1186 562cdac37bb064d2d57d563c89068c6c 512 PRINTS PR01041 Methionyl-tRNA synthetase signature 254 269 2.5E-31 T 13-10-2018 IPR033911 Methioninyl-tRNA synthetase core domain GO:0004825|GO:0006431 KEGG: 00450+6.1.1.10|KEGG: 00970+6.1.1.10 TOPB45_1186 562cdac37bb064d2d57d563c89068c6c 512 PRINTS PR01041 Methionyl-tRNA synthetase signature 38 52 2.5E-31 T 13-10-2018 IPR033911 Methioninyl-tRNA synthetase core domain GO:0004825|GO:0006431 KEGG: 00450+6.1.1.10|KEGG: 00970+6.1.1.10 TOPB45_1186 562cdac37bb064d2d57d563c89068c6c 512 PRINTS PR01041 Methionyl-tRNA synthetase signature 346 357 2.5E-31 T 13-10-2018 IPR033911 Methioninyl-tRNA synthetase core domain GO:0004825|GO:0006431 KEGG: 00450+6.1.1.10|KEGG: 00970+6.1.1.10 TOPB45_1186 562cdac37bb064d2d57d563c89068c6c 512 PRINTS PR01041 Methionyl-tRNA synthetase signature 6 19 2.5E-31 T 13-10-2018 IPR033911 Methioninyl-tRNA synthetase core domain GO:0004825|GO:0006431 KEGG: 00450+6.1.1.10|KEGG: 00970+6.1.1.10 TOPB45_1186 562cdac37bb064d2d57d563c89068c6c 512 PRINTS PR01041 Methionyl-tRNA synthetase signature 86 97 2.5E-31 T 13-10-2018 IPR033911 Methioninyl-tRNA synthetase core domain GO:0004825|GO:0006431 KEGG: 00450+6.1.1.10|KEGG: 00970+6.1.1.10 TOPB45_1186 562cdac37bb064d2d57d563c89068c6c 512 PRINTS PR01041 Methionyl-tRNA synthetase signature 223 234 2.5E-31 T 13-10-2018 IPR033911 Methioninyl-tRNA synthetase core domain GO:0004825|GO:0006431 KEGG: 00450+6.1.1.10|KEGG: 00970+6.1.1.10 TOPB45_1186 562cdac37bb064d2d57d563c89068c6c 512 Pfam PF08264 Anticodon-binding domain of tRNA 380 477 2.9E-9 T 13-10-2018 IPR013155 Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding GO:0004812|GO:0006418 TOPB45_1186 562cdac37bb064d2d57d563c89068c6c 512 Pfam PF00133 tRNA synthetases class I (I, L, M and V) 9 139 4.0E-8 T 13-10-2018 IPR002300 Aminoacyl-tRNA synthetase, class Ia GO:0000166|GO:0004812|GO:0005524|GO:0006418 TOPB45_1186 562cdac37bb064d2d57d563c89068c6c 512 Hamap MF_01228 Methionine--tRNA ligase [metG]. 2 504 41.379 T 13-10-2018 IPR023457 Methionine-tRNA synthetase, type 2 GO:0004825 KEGG: 00450+6.1.1.10|KEGG: 00970+6.1.1.10 TOPB45_1186 562cdac37bb064d2d57d563c89068c6c 512 Gene3D G3DSA:1.10.730.10 337 509 1.3E-48 T 13-10-2018 TOPB45_1186 562cdac37bb064d2d57d563c89068c6c 512 SUPERFAMILY SSF52374 4 345 8.85E-100 T 13-10-2018 TOPB45_1186 562cdac37bb064d2d57d563c89068c6c 512 Gene3D G3DSA:2.170.220.10 115 225 2.4E-136 T 13-10-2018 TOPB45_1186 562cdac37bb064d2d57d563c89068c6c 512 Pfam PF09334 tRNA synthetases class I (M) 141 359 6.8E-61 T 13-10-2018 IPR015413 Methionyl/Leucyl tRNA synthetase GO:0000166|GO:0004812|GO:0005524|GO:0006418 TOPB45_1186 562cdac37bb064d2d57d563c89068c6c 512 TIGRFAM TIGR00398 metG: methionine--tRNA ligase 4 506 2.5E-144 T 13-10-2018 IPR014758 Methionyl-tRNA synthetase GO:0000166|GO:0004825|GO:0005524|GO:0005737|GO:0006431 KEGG: 00450+6.1.1.10|KEGG: 00970+6.1.1.10 TOPB45_0636 00ac3a99bfb8f647d2045f7c1afcc8d5 691 Gene3D G3DSA:3.40.50.12780 78 555 1.6E-91 T 13-10-2018 TOPB45_0636 00ac3a99bfb8f647d2045f7c1afcc8d5 691 ProSitePatterns PS00455 Putative AMP-binding domain signature. 291 302 - T 13-10-2018 IPR020845 AMP-binding, conserved site TOPB45_0636 00ac3a99bfb8f647d2045f7c1afcc8d5 691 Pfam PF16177 Acetyl-coenzyme A synthetase N-terminus 68 103 5.1E-13 T 13-10-2018 IPR032387 Acetyl-coenzyme A synthetase, N-terminal domain KEGG: 00010+6.2.1.1|KEGG: 00620+6.2.1.1|KEGG: 00630+6.2.1.1|KEGG: 00640+6.2.1.1|KEGG: 00680+6.2.1.1|KEGG: 00720+6.2.1.1|MetaCyc: PWY-5108|MetaCyc: PWY-5132|MetaCyc: PWY-5133|MetaCyc: PWY-6672|MetaCyc: PWY-7118|MetaCyc: PWY-7857 TOPB45_0636 00ac3a99bfb8f647d2045f7c1afcc8d5 691 Pfam PF13193 AMP-binding enzyme C-terminal domain 571 649 3.0E-19 T 13-10-2018 IPR025110 AMP-binding enzyme, C-terminal domain TOPB45_0636 00ac3a99bfb8f647d2045f7c1afcc8d5 691 Gene3D G3DSA:3.30.300.30 558 687 1.8E-22 T 13-10-2018 TOPB45_0636 00ac3a99bfb8f647d2045f7c1afcc8d5 691 TIGRFAM TIGR02188 Ac_CoA_lig_AcsA: acetate--CoA ligase 67 681 1.5E-231 T 13-10-2018 IPR011904 Acetate-CoA ligase GO:0003987|GO:0016208|GO:0019427 KEGG: 00010+6.2.1.1|KEGG: 00620+6.2.1.1|KEGG: 00630+6.2.1.1|KEGG: 00640+6.2.1.1|KEGG: 00680+6.2.1.1|KEGG: 00720+6.2.1.1|MetaCyc: PWY-5108|MetaCyc: PWY-5132|MetaCyc: PWY-5133|MetaCyc: PWY-6672|MetaCyc: PWY-7118|MetaCyc: PWY-7857|Reactome: R-HSA-71384 TOPB45_0636 00ac3a99bfb8f647d2045f7c1afcc8d5 691 Pfam PF00501 AMP-binding enzyme 105 562 9.5E-82 T 13-10-2018 IPR000873 AMP-dependent synthetase/ligase GO:0003824 TOPB45_0636 00ac3a99bfb8f647d2045f7c1afcc8d5 691 SUPERFAMILY SSF56801 55 680 2.35E-146 T 13-10-2018 TOPB45_0091 e3c2cd12aefd9405572ec68dd65b5438 488 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 238 262 2.8E-46 T 13-10-2018 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_0091 e3c2cd12aefd9405572ec68dd65b5438 488 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 378 404 2.8E-46 T 13-10-2018 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_0091 e3c2cd12aefd9405572ec68dd65b5438 488 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 169 193 2.8E-46 T 13-10-2018 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_0091 e3c2cd12aefd9405572ec68dd65b5438 488 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 326 345 2.8E-46 T 13-10-2018 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_0091 e3c2cd12aefd9405572ec68dd65b5438 488 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 139 158 2.8E-46 T 13-10-2018 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_0091 e3c2cd12aefd9405572ec68dd65b5438 488 Pfam PF00361 Proton-conducting membrane transporter 133 413 5.3E-81 T 13-10-2018 IPR001750 NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_0091 e3c2cd12aefd9405572ec68dd65b5438 488 TIGRFAM TIGR01972 NDH_I_M: proton-translocating NADH-quinone oxidoreductase, chain M 9 485 5.1E-185 T 13-10-2018 IPR010227 NADH-quinone oxidoreductase, chain M/4 GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_1385 bac3a941c93a2e989aa1c85c2763733d 1386 Gene3D G3DSA:3.30.470.20 1124 1237 1.2E-22 T 13-10-2018 TOPB45_1385 bac3a941c93a2e989aa1c85c2763733d 1386 SUPERFAMILY SSF56059 893 1243 6.47E-80 T 13-10-2018 TOPB45_1385 bac3a941c93a2e989aa1c85c2763733d 1386 Pfam PF01326 Pyruvate phosphate dikinase, PEP/pyruvate binding domain 896 1178 3.6E-24 T 13-10-2018 IPR002192 Pyruvate phosphate dikinase, PEP/pyruvate-binding GO:0005524|GO:0016301|GO:0016310 TOPB45_1385 bac3a941c93a2e989aa1c85c2763733d 1386 SUPERFAMILY SSF52009 1258 1378 2.22E-29 T 13-10-2018 IPR036637 Phosphohistidine domain superfamily GO:0016310|GO:0016772 TOPB45_1385 bac3a941c93a2e989aa1c85c2763733d 1386 Gene3D G3DSA:3.30.1490.20 896 1123 4.4E-81 T 13-10-2018 IPR013815 ATP-grasp fold, subdomain 1 GO:0005524 TOPB45_1385 bac3a941c93a2e989aa1c85c2763733d 1386 Gene3D G3DSA:1.20.80.30 991 1082 4.4E-81 T 13-10-2018 TOPB45_1385 bac3a941c93a2e989aa1c85c2763733d 1386 Pfam PF00391 PEP-utilising enzyme, mobile domain 1289 1370 1.5E-19 T 13-10-2018 IPR008279 PEP-utilising enzyme, mobile domain GO:0016310|GO:0016772 TOPB45_1385 bac3a941c93a2e989aa1c85c2763733d 1386 Gene3D G3DSA:3.50.30.10 1251 1374 8.6E-38 T 13-10-2018 TOPB45_0588 fa4bfe9eb67ce4e2f6bb99da376cc2db 127 ProDom PD003629 P RIBONUCLEASE COMPONENT HYDROLASE RNASE C5 RNASEP RNA-BINDING PROCESSING ENDONUCLEASE 11 115 5.0E-15 T 13-10-2018 IPR000100 Ribonuclease P GO:0000049|GO:0004526|GO:0008033 TOPB45_0588 fa4bfe9eb67ce4e2f6bb99da376cc2db 127 SUPERFAMILY SSF54211 7 104 6.57E-28 T 13-10-2018 IPR020568 Ribosomal protein S5 domain 2-type fold TOPB45_0588 fa4bfe9eb67ce4e2f6bb99da376cc2db 127 ProSitePatterns PS00648 Bacterial ribonuclease P protein component signature. 56 70 - T 13-10-2018 IPR020539 Ribonuclease P, conserved site GO:0004526 TOPB45_0588 fa4bfe9eb67ce4e2f6bb99da376cc2db 127 Gene3D G3DSA:3.30.230.10 2 118 3.5E-33 T 13-10-2018 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup TOPB45_0588 fa4bfe9eb67ce4e2f6bb99da376cc2db 127 Pfam PF00825 Ribonuclease P 7 103 5.4E-27 T 13-10-2018 IPR000100 Ribonuclease P GO:0000049|GO:0004526|GO:0008033 TOPB45_0588 fa4bfe9eb67ce4e2f6bb99da376cc2db 127 TIGRFAM TIGR00188 rnpA: ribonuclease P protein component 8 113 9.6E-24 T 13-10-2018 IPR000100 Ribonuclease P GO:0000049|GO:0004526|GO:0008033 TOPB45_0588 fa4bfe9eb67ce4e2f6bb99da376cc2db 127 Hamap MF_00227 Ribonuclease P protein component [rnpA]. 6 119 17.036 T 13-10-2018 IPR000100 Ribonuclease P GO:0000049|GO:0004526|GO:0008033 TOPB45_0617 edecf4836781586ab4aa5a16db60f4af 225 SUPERFAMILY SSF48150 17 223 4.4E-72 T 13-10-2018 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: R-HSA-110357 TOPB45_0617 edecf4836781586ab4aa5a16db60f4af 225 TIGRFAM TIGR01083 nth: endonuclease III 17 209 1.3E-79 T 13-10-2018 IPR005759 Endonuclease III GO:0003906|GO:0006284 TOPB45_0617 edecf4836781586ab4aa5a16db60f4af 225 Pfam PF00633 Helix-hairpin-helix motif 113 140 1.6E-6 T 13-10-2018 IPR000445 Helix-hairpin-helix motif GO:0003677 Reactome: R-HSA-110357 TOPB45_0617 edecf4836781586ab4aa5a16db60f4af 225 Pfam PF00730 HhH-GPD superfamily base excision DNA repair protein 48 183 3.8E-30 T 13-10-2018 IPR003265 HhH-GPD domain GO:0006284 Reactome: R-HSA-110357 TOPB45_0617 edecf4836781586ab4aa5a16db60f4af 225 SMART SM00478 52 200 3.8E-66 T 13-10-2018 IPR003265 HhH-GPD domain GO:0006284 Reactome: R-HSA-110357 TOPB45_0617 edecf4836781586ab4aa5a16db60f4af 225 Gene3D G3DSA:1.10.340.30 35 146 4.4E-81 T 13-10-2018 TOPB45_0617 edecf4836781586ab4aa5a16db60f4af 225 Hamap MF_00942 Endonuclease III [nth]. 1 224 38.793 T 13-10-2018 IPR005759 Endonuclease III GO:0003906|GO:0006284 TOPB45_0617 edecf4836781586ab4aa5a16db60f4af 225 Gene3D G3DSA:1.10.1670.10 25 218 4.4E-81 T 13-10-2018 IPR023170 Helix-turn-helix, base-excision DNA repair, C-terminal Reactome: R-HSA-110357 TOPB45_0617 edecf4836781586ab4aa5a16db60f4af 225 Pfam PF10576 Iron-sulfur binding domain of endonuclease III 202 218 7.4E-5 T 13-10-2018 IPR003651 Endonuclease III-like, iron-sulphur cluster loop motif GO:0051539 Reactome: R-HSA-110357 TOPB45_0617 edecf4836781586ab4aa5a16db60f4af 225 PIRSF PIRSF001435 12 225 1.1E-56 T 13-10-2018 TOPB45_0617 edecf4836781586ab4aa5a16db60f4af 225 ProSitePatterns PS01155 Endonuclease III family signature. 116 145 - T 13-10-2018 IPR004036 Endonuclease III-like, conserved site-2 Reactome: R-HSA-110357 TOPB45_0617 edecf4836781586ab4aa5a16db60f4af 225 SMART SM00525 201 221 1.5E-6 T 13-10-2018 IPR003651 Endonuclease III-like, iron-sulphur cluster loop motif GO:0051539 Reactome: R-HSA-110357 TOPB45_0617 edecf4836781586ab4aa5a16db60f4af 225 ProSitePatterns PS00764 Endonuclease III iron-sulfur binding region signature. 202 218 - T 13-10-2018 IPR004035 Endonuclease III, iron-sulphur binding site Reactome: R-HSA-110330|Reactome: R-HSA-110331|Reactome: R-HSA-110357 TOPB45_0859 e1c6b13aa891a48fb81deb87f1fdc80b 191 SUPERFAMILY SSF56091 21 190 7.2E-31 T 13-10-2018 TOPB45_0859 e1c6b13aa891a48fb81deb87f1fdc80b 191 Gene3D G3DSA:3.30.470.30 7 190 5.9E-24 T 13-10-2018 TOPB45_0859 e1c6b13aa891a48fb81deb87f1fdc80b 191 Pfam PF01068 ATP dependent DNA ligase domain 19 190 2.4E-20 T 13-10-2018 IPR012310 DNA ligase, ATP-dependent, central GO:0003910|GO:0005524|GO:0006281|GO:0006310 TOPB45_0767 c547db78870b1bb75f35f828c5ee93f2 131 Hamap MF_01302_B 30S ribosomal protein S8 [rpsH]. 1 131 32.991 T 13-10-2018 IPR000630 Ribosomal protein S8 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0767 c547db78870b1bb75f35f828c5ee93f2 131 Gene3D G3DSA:3.30.1370.30 1 72 9.5E-30 T 13-10-2018 TOPB45_0767 c547db78870b1bb75f35f828c5ee93f2 131 Gene3D G3DSA:3.30.1490.10 74 131 1.5E-28 T 13-10-2018 TOPB45_0767 c547db78870b1bb75f35f828c5ee93f2 131 SUPERFAMILY SSF56047 1 131 6.28E-51 T 13-10-2018 IPR035987 Ribosomal protein S8 superfamily GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0767 c547db78870b1bb75f35f828c5ee93f2 131 Pfam PF00410 Ribosomal protein S8 4 131 6.2E-54 T 13-10-2018 IPR000630 Ribosomal protein S8 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0767 c547db78870b1bb75f35f828c5ee93f2 131 ProSitePatterns PS00053 Ribosomal protein S8 signature. 101 118 - T 13-10-2018 IPR000630 Ribosomal protein S8 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0574 208e802f0097610ee75204acf52d1d8d 390 Pfam PF07690 Major Facilitator Superfamily 10 350 5.1E-19 T 13-10-2018 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TOPB45_0574 208e802f0097610ee75204acf52d1d8d 390 SUPERFAMILY SSF103473 4 388 3.27E-32 T 13-10-2018 IPR036259 MFS transporter superfamily TOPB45_0574 208e802f0097610ee75204acf52d1d8d 390 Gene3D G3DSA:1.20.1250.20 1 182 3.6E-13 T 13-10-2018 TOPB45_0574 208e802f0097610ee75204acf52d1d8d 390 Gene3D G3DSA:1.20.1250.20 205 390 1.2E-11 T 13-10-2018 TOPB45_0403 3efdb7fc4267e195ba2ae3c4fdb3ce5f 359 TIGRFAM TIGR01353 dGTP_triPase: putative dGTPase 41 167 2.9E-50 T 13-10-2018 IPR006261 dNTP triphosphohydrolase GO:0016793 TOPB45_0403 3efdb7fc4267e195ba2ae3c4fdb3ce5f 359 SUPERFAMILY SSF109604 30 345 1.24E-80 T 13-10-2018 TOPB45_0403 3efdb7fc4267e195ba2ae3c4fdb3ce5f 359 SMART SM00471 74 206 3.2E-12 T 13-10-2018 IPR003607 HD/PDEase domain TOPB45_0403 3efdb7fc4267e195ba2ae3c4fdb3ce5f 359 Pfam PF13286 Phosphohydrolase-associated domain 252 337 5.2E-19 T 13-10-2018 IPR026875 Phosphohydrolase-associated domain TOPB45_0403 3efdb7fc4267e195ba2ae3c4fdb3ce5f 359 Gene3D G3DSA:1.10.3210.10 4 340 5.2E-114 T 13-10-2018 TOPB45_0403 3efdb7fc4267e195ba2ae3c4fdb3ce5f 359 Pfam PF01966 HD domain 78 195 3.8E-17 T 13-10-2018 IPR006674 HD domain TOPB45_0403 3efdb7fc4267e195ba2ae3c4fdb3ce5f 359 Hamap MF_01212 Deoxyguanosinetriphosphate triphosphohydrolase-like protein. 18 341 32.082 T 13-10-2018 IPR023023 dNTP triphosphohydrolase, type 2 GO:0016793 TOPB45_0409 e2216045cd47f21d8886d76aea407fb5 856 SUPERFAMILY SSF63411 445 647 5.33E-44 T 13-10-2018 IPR011249 Metalloenzyme, LuxS/M16 peptidase-like GO:0003824|GO:0046872 TOPB45_0409 e2216045cd47f21d8886d76aea407fb5 856 Gene3D G3DSA:3.30.830.10 661 855 2.3E-45 T 13-10-2018 TOPB45_0409 e2216045cd47f21d8886d76aea407fb5 856 Gene3D G3DSA:3.30.830.10 233 429 1.3E-43 T 13-10-2018 TOPB45_0409 e2216045cd47f21d8886d76aea407fb5 856 SUPERFAMILY SSF63411 14 227 2.87E-64 T 13-10-2018 IPR011249 Metalloenzyme, LuxS/M16 peptidase-like GO:0003824|GO:0046872 TOPB45_0409 e2216045cd47f21d8886d76aea407fb5 856 Pfam PF00675 Insulinase (Peptidase family M16) 460 563 8.2E-11 T 13-10-2018 IPR011765 Peptidase M16, N-terminal TOPB45_0409 e2216045cd47f21d8886d76aea407fb5 856 Pfam PF00675 Insulinase (Peptidase family M16) 33 171 1.7E-35 T 13-10-2018 IPR011765 Peptidase M16, N-terminal TOPB45_0409 e2216045cd47f21d8886d76aea407fb5 856 SUPERFAMILY SSF63411 243 423 1.48E-33 T 13-10-2018 IPR011249 Metalloenzyme, LuxS/M16 peptidase-like GO:0003824|GO:0046872 TOPB45_0409 e2216045cd47f21d8886d76aea407fb5 856 ProSitePatterns PS00143 Insulinase family, zinc-binding region signature. 46 69 - T 13-10-2018 IPR001431 Peptidase M16, zinc-binding site GO:0004222|GO:0006508 TOPB45_0409 e2216045cd47f21d8886d76aea407fb5 856 Gene3D G3DSA:3.30.830.10 446 654 1.5E-42 T 13-10-2018 TOPB45_0409 e2216045cd47f21d8886d76aea407fb5 856 Pfam PF05193 Peptidase M16 inactive domain 179 354 2.0E-34 T 13-10-2018 IPR007863 Peptidase M16, C-terminal TOPB45_0409 e2216045cd47f21d8886d76aea407fb5 856 Pfam PF05193 Peptidase M16 inactive domain 607 783 2.9E-29 T 13-10-2018 IPR007863 Peptidase M16, C-terminal TOPB45_0409 e2216045cd47f21d8886d76aea407fb5 856 SUPERFAMILY SSF63411 674 852 1.75E-34 T 13-10-2018 IPR011249 Metalloenzyme, LuxS/M16 peptidase-like GO:0003824|GO:0046872 TOPB45_0409 e2216045cd47f21d8886d76aea407fb5 856 Gene3D G3DSA:3.30.830.10 10 232 5.1E-73 T 13-10-2018 TOPB45_1392 f692e7853fb7403a45205dc8fcf30917 155 TIGRFAM TIGR03002 outer_YhbN_LptA: lipopolysaccharide transport periplasmic protein LptA 25 150 4.5E-21 T 13-10-2018 IPR014340 Lipopolysaccharide export system protein LptA GO:0001530|GO:0015920|GO:0042597 TOPB45_1392 f692e7853fb7403a45205dc8fcf30917 155 Pfam PF03968 OstA-like protein 29 136 1.9E-14 T 13-10-2018 IPR005653 Organic solvent tolerance-like, N-terminal TOPB45_1392 f692e7853fb7403a45205dc8fcf30917 155 Gene3D G3DSA:2.60.450.10 23 152 9.0E-21 T 13-10-2018 TOPB45_1456 448c6b6d9eba09a5fc083f4fa9910a3e 510 Gene3D G3DSA:3.40.1010.10 2 119 6.1E-47 T 13-10-2018 IPR014777 Tetrapyrrole methylase, subdomain 1 GO:0008168 Reactome: R-HSA-5358493 TOPB45_1456 448c6b6d9eba09a5fc083f4fa9910a3e 510 PIRSF PIRSF036426 1 255 2.3E-109 T 13-10-2018 IPR012409 Sirohaem synthase GO:0004851|GO:0009236|GO:0019354|GO:0043115|GO:0051266|GO:0051287 KEGG: 00860+4.99.1.4+1.3.1.76+2.1.1.107|MetaCyc: PWY-5194|MetaCyc: PWY-5196|MetaCyc: PWY-7377 TOPB45_1456 448c6b6d9eba09a5fc083f4fa9910a3e 510 SUPERFAMILY SSF53790 2 255 1.96E-83 T 13-10-2018 IPR035996 Tetrapyrrole methylase superfamily GO:0008168 Reactome: R-HSA-5358493 TOPB45_1456 448c6b6d9eba09a5fc083f4fa9910a3e 510 TIGRFAM TIGR01469 cobA_cysG_Cterm: uroporphyrinogen-III C-methyltransferase 4 240 2.3E-101 T 13-10-2018 IPR006366 Uroporphyrin-III C-methyltransferase GO:0008168|GO:0019354 KEGG: 00860+4.99.1.4+1.3.1.76+2.1.1.107|MetaCyc: PWY-5194|MetaCyc: PWY-5196|MetaCyc: PWY-7377 TOPB45_1456 448c6b6d9eba09a5fc083f4fa9910a3e 510 SUPERFAMILY SSF69618 253 503 4.45E-69 T 13-10-2018 IPR036108 Tetrapyrrole biosynthesis, uroporphyrinogen III synthase superfamily GO:0004852|GO:0033014 KEGG: 00860+4.2.1.75|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 TOPB45_1456 448c6b6d9eba09a5fc083f4fa9910a3e 510 Pfam PF00590 Tetrapyrrole (Corrin/Porphyrin) Methylases 5 216 5.3E-51 T 13-10-2018 IPR000878 Tetrapyrrole methylase GO:0008168 Reactome: R-HSA-5358493 TOPB45_1456 448c6b6d9eba09a5fc083f4fa9910a3e 510 Gene3D G3DSA:3.40.50.10090 406 501 3.4E-21 T 13-10-2018 TOPB45_1456 448c6b6d9eba09a5fc083f4fa9910a3e 510 ProSitePatterns PS00840 Uroporphyrin-III C-methyltransferase signature 2. 84 117 - T 13-10-2018 IPR003043 Uroporphiryn-III C-methyltransferase, conserved site GO:0008168|GO:0055114 KEGG: 00860+4.99.1.4+1.3.1.76+2.1.1.107|MetaCyc: PWY-5194|MetaCyc: PWY-5196|MetaCyc: PWY-7377 TOPB45_1456 448c6b6d9eba09a5fc083f4fa9910a3e 510 Gene3D G3DSA:3.40.50.10090 297 405 1.6E-28 T 13-10-2018 TOPB45_1456 448c6b6d9eba09a5fc083f4fa9910a3e 510 Gene3D G3DSA:3.30.950.10 120 270 4.0E-54 T 13-10-2018 IPR014776 Tetrapyrrole methylase, subdomain 2 GO:0008168 Reactome: R-HSA-5358493 TOPB45_1456 448c6b6d9eba09a5fc083f4fa9910a3e 510 Pfam PF02602 Uroporphyrinogen-III synthase HemD 267 494 5.6E-63 T 13-10-2018 IPR003754 Tetrapyrrole biosynthesis, uroporphyrinogen III synthase GO:0004852|GO:0033014 KEGG: 00860+4.2.1.75|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 TOPB45_0202 0c89e5043bbbc159df026d9ca4791166 441 Hamap MF_00249 ATP-dependent protease ATPase subunit HslU [hslU]. 3 441 42.671 T 13-10-2018 IPR004491 Heat shock protein HslU GO:0005524|GO:0005737|GO:0009376|GO:0016887|GO:0070011 TOPB45_0202 0c89e5043bbbc159df026d9ca4791166 441 Gene3D G3DSA:3.40.50.300 8 330 3.0E-105 T 13-10-2018 TOPB45_0202 0c89e5043bbbc159df026d9ca4791166 441 SUPERFAMILY SSF52540 6 437 5.34E-87 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0202 0c89e5043bbbc159df026d9ca4791166 441 SMART SM01086 333 427 3.8E-25 T 13-10-2018 IPR019489 Clp ATPase, C-terminal TOPB45_0202 0c89e5043bbbc159df026d9ca4791166 441 Pfam PF10431 C-terminal, D2-small domain, of ClpB protein 333 403 1.0E-8 T 13-10-2018 IPR019489 Clp ATPase, C-terminal TOPB45_0202 0c89e5043bbbc159df026d9ca4791166 441 Gene3D G3DSA:1.10.8.60 333 438 3.6E-41 T 13-10-2018 TOPB45_0202 0c89e5043bbbc159df026d9ca4791166 441 SMART SM00382 51 330 6.8E-9 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_0202 0c89e5043bbbc159df026d9ca4791166 441 TIGRFAM TIGR00390 hslU: ATP-dependent protease HslVU, ATPase subunit 6 441 1.0E-193 T 13-10-2018 IPR004491 Heat shock protein HslU GO:0005524|GO:0005737|GO:0009376|GO:0016887|GO:0070011 TOPB45_0202 0c89e5043bbbc159df026d9ca4791166 441 Pfam PF07724 AAA domain (Cdc48 subfamily) 189 327 5.5E-40 T 13-10-2018 IPR003959 ATPase, AAA-type, core GO:0005524 TOPB45_0202 0c89e5043bbbc159df026d9ca4791166 441 Pfam PF07724 AAA domain (Cdc48 subfamily) 54 118 1.3E-6 T 13-10-2018 IPR003959 ATPase, AAA-type, core GO:0005524 TOPB45_0202 0c89e5043bbbc159df026d9ca4791166 441 Gene3D G3DSA:1.10.8.10 112 241 3.0E-105 T 13-10-2018 TOPB45_0151 603f5203366d614090099fb0b2eb67e4 1018 TIGRFAM TIGR00348 hsdR: type I site-specific deoxyribonuclease, HsdR family 9 693 6.4E-211 T 13-10-2018 IPR004473 Restriction endonuclease, type I, HsdR GO:0003677|GO:0005524|GO:0009035|GO:0009307 TOPB45_0151 603f5203366d614090099fb0b2eb67e4 1018 Gene3D G3DSA:3.40.50.300 468 695 4.8E-48 T 13-10-2018 TOPB45_0151 603f5203366d614090099fb0b2eb67e4 1018 SUPERFAMILY SSF52540 243 510 6.65E-27 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0151 603f5203366d614090099fb0b2eb67e4 1018 SMART SM00487 286 479 3.8E-16 T 13-10-2018 IPR014001 Helicase superfamily 1/2, ATP-binding domain TOPB45_0151 603f5203366d614090099fb0b2eb67e4 1018 Pfam PF11867 Domain of unknown function (DUF3387) 695 1016 3.7E-85 T 13-10-2018 IPR021810 Protein of unknown function DUF3387 TOPB45_0151 603f5203366d614090099fb0b2eb67e4 1018 Gene3D G3DSA:3.90.1570.50 97 275 1.1E-22 T 13-10-2018 TOPB45_0151 603f5203366d614090099fb0b2eb67e4 1018 Gene3D G3DSA:3.40.50.300 281 467 3.2E-51 T 13-10-2018 TOPB45_0151 603f5203366d614090099fb0b2eb67e4 1018 SUPERFAMILY SSF52540 406 708 2.13E-14 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0151 603f5203366d614090099fb0b2eb67e4 1018 Pfam PF04851 Type III restriction enzyme, res subunit 292 449 2.5E-22 T 13-10-2018 IPR006935 Helicase/UvrB, N-terminal GO:0003677|GO:0005524|GO:0016787 TOPB45_0151 603f5203366d614090099fb0b2eb67e4 1018 Pfam PF04313 Type I restriction enzyme R protein N terminus (HSDR_N) 3 210 1.5E-38 T 13-10-2018 IPR007409 Restriction endonuclease, type I, HsdR, N-terminal GO:0003677|GO:0004519|GO:0006304 TOPB45_1357 48885a49fb6b358726882b7417a07a49 1133 Gene3D G3DSA:3.90.1150.50 993 1131 4.3E-25 T 13-10-2018 IPR037235 TRCF-like, C-terminal domain TOPB45_1357 48885a49fb6b358726882b7417a07a49 1133 TIGRFAM TIGR00580 mfd: transcription-repair coupling factor 147 1068 1.3E-294 T 13-10-2018 IPR004576 Transcription-repair coupling factor GO:0003684|GO:0005524|GO:0006281 TOPB45_1357 48885a49fb6b358726882b7417a07a49 1133 SMART SM01058 474 571 1.2E-35 T 13-10-2018 IPR003711 CarD-like/TRCF domain TOPB45_1357 48885a49fb6b358726882b7417a07a49 1133 Gene3D G3DSA:3.30.2060.10 130 215 1.2E-61 T 13-10-2018 TOPB45_1357 48885a49fb6b358726882b7417a07a49 1133 Pfam PF03461 TRCF domain 998 1086 1.6E-21 T 13-10-2018 IPR005118 Transcription-repair-coupling factor, C-terminal domain GO:0006281 TOPB45_1357 48885a49fb6b358726882b7417a07a49 1133 Gene3D G3DSA:3.40.50.11180 38 334 1.2E-61 T 13-10-2018 TOPB45_1357 48885a49fb6b358726882b7417a07a49 1133 Gene3D G3DSA:2.30.30.840 478 536 2.2E-219 T 13-10-2018 TOPB45_1357 48885a49fb6b358726882b7417a07a49 1133 SUPERFAMILY SSF52540 15 348 3.07E-56 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1357 48885a49fb6b358726882b7417a07a49 1133 Pfam PF02559 CarD-like/TRCF domain 475 570 5.6E-23 T 13-10-2018 IPR003711 CarD-like/TRCF domain TOPB45_1357 48885a49fb6b358726882b7417a07a49 1133 Hamap MF_00969 Transcription-repair-coupling factor [mfd]. 38 1092 25.273 T 13-10-2018 IPR004576 Transcription-repair coupling factor GO:0003684|GO:0005524|GO:0006281 TOPB45_1357 48885a49fb6b358726882b7417a07a49 1133 SUPERFAMILY SSF52540 777 985 8.1E-43 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1357 48885a49fb6b358726882b7417a07a49 1133 Gene3D G3DSA:3.40.50.300 537 776 2.2E-219 T 13-10-2018 TOPB45_1357 48885a49fb6b358726882b7417a07a49 1133 SUPERFAMILY SSF143517 988 1104 4.32E-27 T 13-10-2018 IPR037235 TRCF-like, C-terminal domain TOPB45_1357 48885a49fb6b358726882b7417a07a49 1133 SMART SM00490 821 905 5.4E-19 T 13-10-2018 IPR001650 Helicase, C-terminal TOPB45_1357 48885a49fb6b358726882b7417a07a49 1133 SUPERFAMILY SSF141259 466 543 9.15E-22 T 13-10-2018 IPR036101 CarD-like/TRCF domain superfamily TOPB45_1357 48885a49fb6b358726882b7417a07a49 1133 SMART SM00487 595 785 4.3E-38 T 13-10-2018 IPR014001 Helicase superfamily 1/2, ATP-binding domain TOPB45_1357 48885a49fb6b358726882b7417a07a49 1133 Gene3D G3DSA:3.40.50.300 473 985 2.2E-219 T 13-10-2018 TOPB45_1357 48885a49fb6b358726882b7417a07a49 1133 SMART SM00982 997 1092 1.3E-21 T 13-10-2018 IPR005118 Transcription-repair-coupling factor, C-terminal domain GO:0006281 TOPB45_1357 48885a49fb6b358726882b7417a07a49 1133 SUPERFAMILY SSF52540 536 779 2.13E-59 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1357 48885a49fb6b358726882b7417a07a49 1133 Pfam PF00270 DEAD/DEAH box helicase 600 759 1.4E-18 T 13-10-2018 IPR011545 DEAD/DEAH box helicase domain GO:0003676|GO:0005524 TOPB45_1357 48885a49fb6b358726882b7417a07a49 1133 Pfam PF00271 Helicase conserved C-terminal domain 799 904 1.2E-14 T 13-10-2018 IPR001650 Helicase, C-terminal TOPB45_0707 aae45654a2f07ba805f70ba841cc4a83 79 Hamap MF_00088 UPF0109 protein . 4 78 23.478 T 13-10-2018 IPR020627 Uncharacterised protein family UPF0109 TOPB45_0707 aae45654a2f07ba805f70ba841cc4a83 79 Gene3D G3DSA:3.30.300.20 4 66 7.2E-6 T 13-10-2018 IPR015946 K homology domain-like, alpha/beta TOPB45_0707 aae45654a2f07ba805f70ba841cc4a83 79 SUPERFAMILY SSF54814 8 64 7.19E-8 T 13-10-2018 IPR009019 K homology domain superfamily, prokaryotic type GO:0003723 TOPB45_0707 aae45654a2f07ba805f70ba841cc4a83 79 Pfam PF13083 KH domain 5 77 5.2E-24 T 13-10-2018 TOPB45_1452 a938fd6c408aeddeffaa9a44e70789db 316 Pfam PF02606 Tetraacyldisaccharide-1-P 4'-kinase 11 304 9.0E-70 T 13-10-2018 IPR003758 Tetraacyldisaccharide 4'-kinase GO:0005524|GO:0009029|GO:0009245 KEGG: 00540+2.7.1.130 TOPB45_1452 a938fd6c408aeddeffaa9a44e70789db 316 SUPERFAMILY SSF52540 34 158 3.77E-8 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1452 a938fd6c408aeddeffaa9a44e70789db 316 TIGRFAM TIGR00682 lpxK: tetraacyldisaccharide 4'-kinase 12 301 4.0E-66 T 13-10-2018 IPR003758 Tetraacyldisaccharide 4'-kinase GO:0005524|GO:0009029|GO:0009245 KEGG: 00540+2.7.1.130 TOPB45_1452 a938fd6c408aeddeffaa9a44e70789db 316 Hamap MF_00409 Tetraacyldisaccharide 4'-kinase [lpxK]. 7 314 25.143 T 13-10-2018 IPR003758 Tetraacyldisaccharide 4'-kinase GO:0005524|GO:0009029|GO:0009245 KEGG: 00540+2.7.1.130 TOPB45_0606 9765ad11b42cc9bd18bf412fa57591c5 422 Gene3D G3DSA:3.40.980.10 3 164 1.4E-39 T 13-10-2018 IPR036425 MoaB/Mog-like domain superfamily TOPB45_0606 9765ad11b42cc9bd18bf412fa57591c5 422 SUPERFAMILY SSF142433 244 402 9.02E-55 T 13-10-2018 IPR036653 CinA-like, C-terminal TOPB45_0606 9765ad11b42cc9bd18bf412fa57591c5 422 SMART SM00852 4 168 5.0E-19 T 13-10-2018 IPR001453 MoaB/Mog domain TOPB45_0606 9765ad11b42cc9bd18bf412fa57591c5 422 Pfam PF00994 Probable molybdopterin binding domain 5 165 1.9E-23 T 13-10-2018 IPR001453 MoaB/Mog domain TOPB45_0606 9765ad11b42cc9bd18bf412fa57591c5 422 TIGRFAM TIGR00199 PncC_domain: amidohydrolase, PncC family 255 401 1.7E-47 T 13-10-2018 IPR008136 CinA, C-terminal TOPB45_0606 9765ad11b42cc9bd18bf412fa57591c5 422 Gene3D G3DSA:3.90.950.20 233 403 2.4E-56 T 13-10-2018 IPR036653 CinA-like, C-terminal TOPB45_0606 9765ad11b42cc9bd18bf412fa57591c5 422 Hamap MF_00226_B Putative competence-damage inducible protein [cinA]. 1 422 110.558 T 13-10-2018 IPR008135 Competence-induced protein CinA TOPB45_0606 9765ad11b42cc9bd18bf412fa57591c5 422 SUPERFAMILY SSF53218 4 195 4.97E-29 T 13-10-2018 IPR036425 MoaB/Mog-like domain superfamily TOPB45_0606 9765ad11b42cc9bd18bf412fa57591c5 422 PIRSF PIRSF006728 1 408 6.5E-100 T 13-10-2018 IPR008135 Competence-induced protein CinA TOPB45_0606 9765ad11b42cc9bd18bf412fa57591c5 422 Pfam PF02464 Competence-damaged protein 249 402 7.5E-55 T 13-10-2018 IPR008136 CinA, C-terminal TOPB45_0750 0a0a10909a01ce80c1ed829ee5790e94 694 TIGRFAM TIGR00484 EF-G: translation elongation factor G 9 692 0.0 T 13-10-2018 IPR004540 Translation elongation factor EFG/EF2 GO:0003746|GO:0005525|GO:0005622|GO:0006414 Reactome: R-HSA-5389840 TOPB45_0750 0a0a10909a01ce80c1ed829ee5790e94 694 Pfam PF00679 Elongation factor G C-terminus 600 685 4.3E-31 T 13-10-2018 IPR000640 Elongation factor EFG, domain V-like TOPB45_0750 0a0a10909a01ce80c1ed829ee5790e94 694 SUPERFAMILY SSF50447 266 403 4.29E-35 T 13-10-2018 IPR009000 Translation protein, beta-barrel domain superfamily TOPB45_0750 0a0a10909a01ce80c1ed829ee5790e94 694 Hamap MF_00054_B Elongation factor G [fusA]. 8 691 111.821 T 13-10-2018 IPR004540 Translation elongation factor EFG/EF2 GO:0003746|GO:0005525|GO:0005622|GO:0006414 Reactome: R-HSA-5389840 TOPB45_0750 0a0a10909a01ce80c1ed829ee5790e94 694 SUPERFAMILY SSF52540 10 283 4.18E-109 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0750 0a0a10909a01ce80c1ed829ee5790e94 694 SMART SM00838 600 687 1.3E-56 T 13-10-2018 IPR000640 Elongation factor EFG, domain V-like TOPB45_0750 0a0a10909a01ce80c1ed829ee5790e94 694 ProSitePatterns PS00301 Translational (tr)-type guanine nucleotide-binding (G) domain signature. 53 68 - T 13-10-2018 IPR031157 Tr-type G domain, conserved site TOPB45_0750 0a0a10909a01ce80c1ed829ee5790e94 694 Pfam PF14492 Elongation Factor G, domain II 405 479 2.4E-31 T 13-10-2018 TOPB45_0750 0a0a10909a01ce80c1ed829ee5790e94 694 Gene3D G3DSA:3.40.50.300 7 294 8.0E-117 T 13-10-2018 TOPB45_0750 0a0a10909a01ce80c1ed829ee5790e94 694 Gene3D G3DSA:2.40.30.10 295 406 3.4E-42 T 13-10-2018 TOPB45_0750 0a0a10909a01ce80c1ed829ee5790e94 694 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 11 182 3.4E-30 T 13-10-2018 IPR005225 Small GTP-binding protein domain GO:0005525 TOPB45_0750 0a0a10909a01ce80c1ed829ee5790e94 694 Pfam PF03764 Elongation factor G, domain IV 480 598 6.5E-47 T 13-10-2018 IPR005517 Translation elongation factor EFG/EF2, domain IV GO:0005525 TOPB45_0750 0a0a10909a01ce80c1ed829ee5790e94 694 SUPERFAMILY SSF54211 483 599 1.67E-45 T 13-10-2018 IPR020568 Ribosomal protein S5 domain 2-type fold TOPB45_0750 0a0a10909a01ce80c1ed829ee5790e94 694 Gene3D G3DSA:3.30.70.870 407 484 5.6E-31 T 13-10-2018 TOPB45_0750 0a0a10909a01ce80c1ed829ee5790e94 694 SMART SM00889 481 598 6.9E-72 T 13-10-2018 IPR005517 Translation elongation factor EFG/EF2, domain IV GO:0005525 TOPB45_0750 0a0a10909a01ce80c1ed829ee5790e94 694 Pfam PF03144 Elongation factor Tu domain 2 325 392 3.3E-17 T 13-10-2018 IPR004161 Translation elongation factor EFTu-like, domain 2 GO:0005525 TOPB45_0750 0a0a10909a01ce80c1ed829ee5790e94 694 PRINTS PR00315 GTP-binding elongation factor signature 14 27 2.7E-16 T 13-10-2018 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TOPB45_0750 0a0a10909a01ce80c1ed829ee5790e94 694 PRINTS PR00315 GTP-binding elongation factor signature 132 141 2.7E-16 T 13-10-2018 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TOPB45_0750 0a0a10909a01ce80c1ed829ee5790e94 694 PRINTS PR00315 GTP-binding elongation factor signature 60 68 2.7E-16 T 13-10-2018 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TOPB45_0750 0a0a10909a01ce80c1ed829ee5790e94 694 PRINTS PR00315 GTP-binding elongation factor signature 96 107 2.7E-16 T 13-10-2018 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TOPB45_0750 0a0a10909a01ce80c1ed829ee5790e94 694 PRINTS PR00315 GTP-binding elongation factor signature 80 90 2.7E-16 T 13-10-2018 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TOPB45_0750 0a0a10909a01ce80c1ed829ee5790e94 694 Gene3D G3DSA:3.30.70.240 604 674 4.0E-95 T 13-10-2018 TOPB45_0750 0a0a10909a01ce80c1ed829ee5790e94 694 Gene3D G3DSA:3.30.230.10 485 687 4.0E-95 T 13-10-2018 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup TOPB45_0750 0a0a10909a01ce80c1ed829ee5790e94 694 SUPERFAMILY SSF54980 405 482 5.04E-24 T 13-10-2018 IPR035647 EF-G domain III/V-like TOPB45_0750 0a0a10909a01ce80c1ed829ee5790e94 694 Pfam PF00009 Elongation factor Tu GTP binding domain 11 283 1.8E-67 T 13-10-2018 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TOPB45_0750 0a0a10909a01ce80c1ed829ee5790e94 694 SUPERFAMILY SSF54980 600 690 1.2E-30 T 13-10-2018 IPR035647 EF-G domain III/V-like TOPB45_1032 15cd2ff19f31f57baa54afedf4e804d4 442 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 207 431 3.8E-37 T 13-10-2018 IPR014284 RNA polymerase sigma-70 like domain GO:0003700|GO:0006352|GO:0006355 TOPB45_1032 15cd2ff19f31f57baa54afedf4e804d4 442 ProSitePatterns PS00715 Sigma-70 factors family signature 1. 235 248 - T 13-10-2018 IPR000943 RNA polymerase sigma-70 GO:0003700|GO:0006352|GO:0006355 TOPB45_1032 15cd2ff19f31f57baa54afedf4e804d4 442 Pfam PF04542 Sigma-70 region 2 211 280 5.8E-19 T 13-10-2018 IPR007627 RNA polymerase sigma-70 region 2 GO:0003700|GO:0006352|GO:0006355 TOPB45_1032 15cd2ff19f31f57baa54afedf4e804d4 442 Pfam PF00140 Sigma-70 factor, region 1.2 98 126 3.2E-9 T 13-10-2018 IPR009042 RNA polymerase sigma-70 region 1.2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TOPB45_1032 15cd2ff19f31f57baa54afedf4e804d4 442 SUPERFAMILY SSF88946 96 281 8.95E-49 T 13-10-2018 IPR013325 RNA polymerase sigma factor, region 2 GO:0003700|GO:0006352|GO:0006355 TOPB45_1032 15cd2ff19f31f57baa54afedf4e804d4 442 Pfam PF04539 Sigma-70 region 3 290 364 1.1E-19 T 13-10-2018 IPR007624 RNA polymerase sigma-70 region 3 GO:0003700|GO:0006352|GO:0006355 TOPB45_1032 15cd2ff19f31f57baa54afedf4e804d4 442 SUPERFAMILY SSF88659 284 354 4.36E-15 T 13-10-2018 IPR013324 RNA polymerase sigma factor, region 3/4-like TOPB45_1032 15cd2ff19f31f57baa54afedf4e804d4 442 Gene3D G3DSA:1.10.601.10 158 280 5.4E-47 T 13-10-2018 TOPB45_1032 15cd2ff19f31f57baa54afedf4e804d4 442 PRINTS PR00046 Major sigma-70 factor signature 235 248 1.9E-28 T 13-10-2018 IPR000943 RNA polymerase sigma-70 GO:0003700|GO:0006352|GO:0006355 TOPB45_1032 15cd2ff19f31f57baa54afedf4e804d4 442 PRINTS PR00046 Major sigma-70 factor signature 382 394 1.9E-28 T 13-10-2018 IPR000943 RNA polymerase sigma-70 GO:0003700|GO:0006352|GO:0006355 TOPB45_1032 15cd2ff19f31f57baa54afedf4e804d4 442 PRINTS PR00046 Major sigma-70 factor signature 418 429 1.9E-28 T 13-10-2018 IPR000943 RNA polymerase sigma-70 GO:0003700|GO:0006352|GO:0006355 TOPB45_1032 15cd2ff19f31f57baa54afedf4e804d4 442 PRINTS PR00046 Major sigma-70 factor signature 259 267 1.9E-28 T 13-10-2018 IPR000943 RNA polymerase sigma-70 GO:0003700|GO:0006352|GO:0006355 TOPB45_1032 15cd2ff19f31f57baa54afedf4e804d4 442 PRINTS PR00046 Major sigma-70 factor signature 403 418 1.9E-28 T 13-10-2018 IPR000943 RNA polymerase sigma-70 GO:0003700|GO:0006352|GO:0006355 TOPB45_1032 15cd2ff19f31f57baa54afedf4e804d4 442 Gene3D G3DSA:1.10.220.120 3 59 2.3E-8 T 13-10-2018 TOPB45_1032 15cd2ff19f31f57baa54afedf4e804d4 442 ProSitePatterns PS00716 Sigma-70 factors family signature 2. 403 429 - T 13-10-2018 IPR000943 RNA polymerase sigma-70 GO:0003700|GO:0006352|GO:0006355 TOPB45_1032 15cd2ff19f31f57baa54afedf4e804d4 442 SUPERFAMILY SSF88659 345 436 8.22E-25 T 13-10-2018 IPR013324 RNA polymerase sigma factor, region 3/4-like TOPB45_1032 15cd2ff19f31f57baa54afedf4e804d4 442 Gene3D G3DSA:1.10.10.10 360 441 4.4E-27 T 13-10-2018 IPR036388 Winged helix-like DNA-binding domain superfamily TOPB45_1032 15cd2ff19f31f57baa54afedf4e804d4 442 Pfam PF04545 Sigma-70, region 4 379 431 2.1E-19 T 13-10-2018 IPR007630 RNA polymerase sigma-70 region 4 GO:0003700|GO:0006352|GO:0006355 TOPB45_1032 15cd2ff19f31f57baa54afedf4e804d4 442 Pfam PF03979 Sigma-70 factor, region 1.1 10 71 1.6E-8 T 13-10-2018 IPR007127 RNA polymerase sigma factor 70, region 1.1 GO:0003677|GO:0006355 TOPB45_1032 15cd2ff19f31f57baa54afedf4e804d4 442 Gene3D G3DSA:1.10.10.10 284 358 5.6E-21 T 13-10-2018 IPR036388 Winged helix-like DNA-binding domain superfamily TOPB45_1032 15cd2ff19f31f57baa54afedf4e804d4 442 Gene3D G3DSA:1.10.601.10 94 157 1.8E-7 T 13-10-2018 TOPB45_0628 5440dbdf60b7bdd05fc40f5d8bc09853 402 Gene3D G3DSA:3.30.540.10 1 142 7.2E-45 T 13-10-2018 TOPB45_0628 5440dbdf60b7bdd05fc40f5d8bc09853 402 Gene3D G3DSA:3.90.79.10 269 399 2.7E-40 T 13-10-2018 TOPB45_0628 5440dbdf60b7bdd05fc40f5d8bc09853 402 PRINTS PR00377 Inositol monophosphatase superfamily signature 179 200 4.0E-48 T 13-10-2018 IPR000760 Inositol monophosphatase-like GO:0046854 TOPB45_0628 5440dbdf60b7bdd05fc40f5d8bc09853 402 PRINTS PR00377 Inositol monophosphatase superfamily signature 60 76 4.0E-48 T 13-10-2018 IPR000760 Inositol monophosphatase-like GO:0046854 TOPB45_0628 5440dbdf60b7bdd05fc40f5d8bc09853 402 PRINTS PR00377 Inositol monophosphatase superfamily signature 38 58 4.0E-48 T 13-10-2018 IPR000760 Inositol monophosphatase-like GO:0046854 TOPB45_0628 5440dbdf60b7bdd05fc40f5d8bc09853 402 PRINTS PR00377 Inositol monophosphatase superfamily signature 131 154 4.0E-48 T 13-10-2018 IPR000760 Inositol monophosphatase-like GO:0046854 TOPB45_0628 5440dbdf60b7bdd05fc40f5d8bc09853 402 PRINTS PR00377 Inositol monophosphatase superfamily signature 82 98 4.0E-48 T 13-10-2018 IPR000760 Inositol monophosphatase-like GO:0046854 TOPB45_0628 5440dbdf60b7bdd05fc40f5d8bc09853 402 PRINTS PR00377 Inositol monophosphatase superfamily signature 210 234 4.0E-48 T 13-10-2018 IPR000760 Inositol monophosphatase-like GO:0046854 TOPB45_0628 5440dbdf60b7bdd05fc40f5d8bc09853 402 Pfam PF00293 NUDIX domain 275 392 4.0E-19 T 13-10-2018 IPR000086 NUDIX hydrolase domain GO:0016787 TOPB45_0628 5440dbdf60b7bdd05fc40f5d8bc09853 402 Gene3D G3DSA:3.40.190.80 143 268 1.9E-37 T 13-10-2018 TOPB45_0628 5440dbdf60b7bdd05fc40f5d8bc09853 402 SUPERFAMILY SSF55811 266 398 6.23E-32 T 13-10-2018 IPR015797 NUDIX hydrolase-like domain superfamily GO:0016787 TOPB45_0628 5440dbdf60b7bdd05fc40f5d8bc09853 402 PRINTS PR00502 NUDIX hydrolase family signature 299 313 2.0E-6 T 13-10-2018 IPR020476 NUDIX hydrolase Reactome: R-HSA-2393930 TOPB45_0628 5440dbdf60b7bdd05fc40f5d8bc09853 402 PRINTS PR00502 NUDIX hydrolase family signature 313 328 2.0E-6 T 13-10-2018 IPR020476 NUDIX hydrolase Reactome: R-HSA-2393930 TOPB45_0628 5440dbdf60b7bdd05fc40f5d8bc09853 402 Pfam PF00459 Inositol monophosphatase family 12 260 5.2E-62 T 13-10-2018 IPR000760 Inositol monophosphatase-like GO:0046854 TOPB45_0628 5440dbdf60b7bdd05fc40f5d8bc09853 402 SUPERFAMILY SSF56655 4 263 6.54E-80 T 13-10-2018 TOPB45_0628 5440dbdf60b7bdd05fc40f5d8bc09853 402 ProSitePatterns PS00893 Nudix box signature. 304 325 - T 13-10-2018 IPR020084 NUDIX hydrolase, conserved site GO:0016787 TOPB45_0628 5440dbdf60b7bdd05fc40f5d8bc09853 402 ProSitePatterns PS00629 Inositol monophosphatase family signature 1. 82 95 - T 13-10-2018 IPR020583 Inositol monophosphatase, metal-binding site TOPB45_0835 d4ce8e7c97397d3f2e60e11b5f0be431 476 SUPERFAMILY SSF50249 100 177 1.25E-7 T 13-10-2018 IPR012340 Nucleic acid-binding, OB-fold TOPB45_0835 d4ce8e7c97397d3f2e60e11b5f0be431 476 PRINTS PR00681 Ribosomal protein S1 signature 85 104 1.6E-34 T 13-10-2018 TOPB45_0835 d4ce8e7c97397d3f2e60e11b5f0be431 476 PRINTS PR00681 Ribosomal protein S1 signature 214 235 1.6E-34 T 13-10-2018 TOPB45_0835 d4ce8e7c97397d3f2e60e11b5f0be431 476 PRINTS PR00681 Ribosomal protein S1 signature 292 311 1.6E-34 T 13-10-2018 TOPB45_0835 d4ce8e7c97397d3f2e60e11b5f0be431 476 PRINTS PR00681 Ribosomal protein S1 signature 109 125 1.6E-34 T 13-10-2018 TOPB45_0835 d4ce8e7c97397d3f2e60e11b5f0be431 476 PRINTS PR00681 Ribosomal protein S1 signature 40 54 1.6E-34 T 13-10-2018 TOPB45_0835 d4ce8e7c97397d3f2e60e11b5f0be431 476 PRINTS PR00681 Ribosomal protein S1 signature 22 40 1.6E-34 T 13-10-2018 TOPB45_0835 d4ce8e7c97397d3f2e60e11b5f0be431 476 PRINTS PR00681 Ribosomal protein S1 signature 331 349 1.6E-34 T 13-10-2018 TOPB45_0835 d4ce8e7c97397d3f2e60e11b5f0be431 476 PRINTS PR00681 Ribosomal protein S1 signature 156 176 1.6E-34 T 13-10-2018 TOPB45_0835 d4ce8e7c97397d3f2e60e11b5f0be431 476 SMART SM00316 277 348 3.3E-24 T 13-10-2018 IPR022967 RNA-binding domain, S1 TOPB45_0835 d4ce8e7c97397d3f2e60e11b5f0be431 476 SMART SM00316 363 441 3.8E-10 T 13-10-2018 IPR022967 RNA-binding domain, S1 TOPB45_0835 d4ce8e7c97397d3f2e60e11b5f0be431 476 SMART SM00316 191 262 8.2E-17 T 13-10-2018 IPR022967 RNA-binding domain, S1 TOPB45_0835 d4ce8e7c97397d3f2e60e11b5f0be431 476 SMART SM00316 104 172 0.0095 T 13-10-2018 IPR022967 RNA-binding domain, S1 TOPB45_0835 d4ce8e7c97397d3f2e60e11b5f0be431 476 SMART SM00316 20 88 7.8E-15 T 13-10-2018 IPR022967 RNA-binding domain, S1 TOPB45_0835 d4ce8e7c97397d3f2e60e11b5f0be431 476 Pfam PF00575 S1 RNA binding domain 190 262 2.6E-11 T 13-10-2018 IPR003029 S1 domain GO:0003676 TOPB45_0835 d4ce8e7c97397d3f2e60e11b5f0be431 476 Pfam PF00575 S1 RNA binding domain 275 348 9.7E-19 T 13-10-2018 IPR003029 S1 domain GO:0003676 TOPB45_0835 d4ce8e7c97397d3f2e60e11b5f0be431 476 Pfam PF00575 S1 RNA binding domain 363 440 5.4E-6 T 13-10-2018 IPR003029 S1 domain GO:0003676 TOPB45_0835 d4ce8e7c97397d3f2e60e11b5f0be431 476 Pfam PF00575 S1 RNA binding domain 19 86 2.6E-9 T 13-10-2018 IPR003029 S1 domain GO:0003676 TOPB45_0835 d4ce8e7c97397d3f2e60e11b5f0be431 476 SUPERFAMILY SSF50249 351 443 2.31E-12 T 13-10-2018 IPR012340 Nucleic acid-binding, OB-fold TOPB45_0835 d4ce8e7c97397d3f2e60e11b5f0be431 476 SUPERFAMILY SSF50249 176 267 2.76E-18 T 13-10-2018 IPR012340 Nucleic acid-binding, OB-fold TOPB45_0835 d4ce8e7c97397d3f2e60e11b5f0be431 476 Gene3D G3DSA:2.40.50.140 185 271 3.2E-17 T 13-10-2018 TOPB45_0835 d4ce8e7c97397d3f2e60e11b5f0be431 476 Gene3D G3DSA:2.40.50.140 99 184 3.8E-5 T 13-10-2018 TOPB45_0835 d4ce8e7c97397d3f2e60e11b5f0be431 476 Gene3D G3DSA:2.40.50.140 358 454 2.0E-12 T 13-10-2018 TOPB45_0835 d4ce8e7c97397d3f2e60e11b5f0be431 476 Gene3D G3DSA:2.40.50.140 272 357 7.4E-25 T 13-10-2018 TOPB45_0835 d4ce8e7c97397d3f2e60e11b5f0be431 476 Gene3D G3DSA:2.40.50.140 8 98 4.5E-21 T 13-10-2018 TOPB45_0835 d4ce8e7c97397d3f2e60e11b5f0be431 476 SUPERFAMILY SSF50249 263 353 2.93E-22 T 13-10-2018 IPR012340 Nucleic acid-binding, OB-fold TOPB45_0835 d4ce8e7c97397d3f2e60e11b5f0be431 476 SUPERFAMILY SSF50249 6 113 3.23E-20 T 13-10-2018 IPR012340 Nucleic acid-binding, OB-fold TOPB45_0973 5db00e41b5bc28c0ac212f296b8ea108 448 TIGRFAM TIGR00089 TIGR00089: radical SAM methylthiotransferase, MiaB/RimO family 4 440 1.3E-157 T 13-10-2018 IPR005839 Methylthiotransferase GO:0006400|GO:0016740|GO:0051539 TOPB45_0973 5db00e41b5bc28c0ac212f296b8ea108 448 Pfam PF04055 Radical SAM superfamily 155 326 3.3E-38 T 13-10-2018 IPR007197 Radical SAM GO:0003824|GO:0051536 TOPB45_0973 5db00e41b5bc28c0ac212f296b8ea108 448 Gene3D G3DSA:3.80.30.20 148 383 2.4E-97 T 13-10-2018 IPR023404 Radical SAM, alpha/beta horseshoe TOPB45_0973 5db00e41b5bc28c0ac212f296b8ea108 448 SMART SM00729 151 369 4.2E-64 T 13-10-2018 IPR006638 Elp3/MiaB/NifB GO:0003824|GO:0051536 TOPB45_0973 5db00e41b5bc28c0ac212f296b8ea108 448 TIGRFAM TIGR01574 miaB-methiolase: tRNA-i(6)A37 thiotransferase enzyme MiaB 5 441 5.9E-164 T 13-10-2018 TOPB45_0973 5db00e41b5bc28c0ac212f296b8ea108 448 Hamap MF_01864 tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase [miaB]. 3 444 71.172 T 13-10-2018 IPR006463 tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase MiaB GO:0005737|GO:0006400|GO:0016740|GO:0051539 TOPB45_0973 5db00e41b5bc28c0ac212f296b8ea108 448 Pfam PF00919 Uncharacterized protein family UPF0004 4 102 6.0E-29 T 13-10-2018 IPR013848 Methylthiotransferase, N-terminal GO:0051539 TOPB45_0973 5db00e41b5bc28c0ac212f296b8ea108 448 Pfam PF01938 TRAM domain 381 442 6.6E-12 T 13-10-2018 IPR002792 TRAM domain TOPB45_0973 5db00e41b5bc28c0ac212f296b8ea108 448 SUPERFAMILY SSF102114 141 380 2.09E-65 T 13-10-2018 TOPB45_0973 5db00e41b5bc28c0ac212f296b8ea108 448 ProSitePatterns PS01278 Methylthiotransferase radical SAM domain signature. 155 175 - T 13-10-2018 IPR020612 Methylthiotransferase, conserved site GO:0051539 TOPB45_0973 5db00e41b5bc28c0ac212f296b8ea108 448 Gene3D G3DSA:3.40.50.12160 3 131 2.7E-33 T 13-10-2018 IPR038135 Methylthiotransferase, N-terminal domain superfamily TOPB45_0006 73b64e8a093e8a801f731e2f1c2aaff5 164 TIGRFAM TIGR02532 IV_pilin_GFxxxE: prepilin-type N-terminal cleavage/methylation domain 11 33 1.4E-6 T 13-10-2018 IPR012902 Prokaryotic N-terminal methylation site TOPB45_0006 73b64e8a093e8a801f731e2f1c2aaff5 164 Gene3D G3DSA:3.30.700.10 14 131 1.8E-7 T 13-10-2018 TOPB45_0006 73b64e8a093e8a801f731e2f1c2aaff5 164 Pfam PF07963 Prokaryotic N-terminal methylation motif 10 33 4.3E-5 T 13-10-2018 IPR012902 Prokaryotic N-terminal methylation site TOPB45_0006 73b64e8a093e8a801f731e2f1c2aaff5 164 ProSitePatterns PS00409 Prokaryotic N-terminal methylation site. 12 32 - T 13-10-2018 IPR012902 Prokaryotic N-terminal methylation site TOPB45_0006 73b64e8a093e8a801f731e2f1c2aaff5 164 SUPERFAMILY SSF54523 14 130 1.65E-11 T 13-10-2018 TOPB45_0644 605c6c269e35bdd1988a8320f7b29c63 143 SUPERFAMILY SSF55021 71 140 2.08E-14 T 13-10-2018 TOPB45_0644 605c6c269e35bdd1988a8320f7b29c63 143 SUPERFAMILY SSF55021 1 68 1.46E-16 T 13-10-2018 TOPB45_0644 605c6c269e35bdd1988a8320f7b29c63 143 Gene3D G3DSA:3.30.2130.10 1 143 5.0E-54 T 13-10-2018 TOPB45_0644 605c6c269e35bdd1988a8320f7b29c63 143 Pfam PF01842 ACT domain 71 118 2.0E-6 T 13-10-2018 IPR002912 ACT domain TOPB45_0040 5d9eefafc6e67f2854b3167038141725 161 Pfam PF01967 MoaC family 15 150 1.4E-51 T 13-10-2018 IPR002820 Molybdopterin cofactor biosynthesis C (MoaC) domain GO:0006777 KEGG: 00790+4.6.1.17|MetaCyc: PWY-6823|Reactome: R-HSA-947581 TOPB45_0040 5d9eefafc6e67f2854b3167038141725 161 TIGRFAM TIGR00581 moaC: molybdenum cofactor biosynthesis protein C 4 152 2.5E-57 T 13-10-2018 IPR023045 Molybdenum cofactor biosynthesis C GO:0006777 KEGG: 00790+4.6.1.17|MetaCyc: PWY-6823|Reactome: R-HSA-947581 TOPB45_0040 5d9eefafc6e67f2854b3167038141725 161 Hamap MF_01224_B Cyclic pyranopterin monophosphate synthase [moaC]. 2 158 33.066 T 13-10-2018 IPR023045 Molybdenum cofactor biosynthesis C GO:0006777 KEGG: 00790+4.6.1.17|MetaCyc: PWY-6823|Reactome: R-HSA-947581 TOPB45_0040 5d9eefafc6e67f2854b3167038141725 161 Gene3D G3DSA:3.30.70.640 1 160 1.3E-61 T 13-10-2018 IPR036522 Molybdopterin cofactor biosynthesis C (MoaC) domain superfamily GO:0006777 KEGG: 00790+4.6.1.17|MetaCyc: PWY-6823|Reactome: R-HSA-947581 TOPB45_0040 5d9eefafc6e67f2854b3167038141725 161 SUPERFAMILY SSF55040 11 154 4.18E-55 T 13-10-2018 IPR036522 Molybdopterin cofactor biosynthesis C (MoaC) domain superfamily GO:0006777 KEGG: 00790+4.6.1.17|MetaCyc: PWY-6823|Reactome: R-HSA-947581 TOPB45_1545 e7fd420da9a16555dabe1d3a1e560528 142 TIGRFAM TIGR01216 ATP_synt_epsi: ATP synthase F1, epsilon subunit 5 133 4.2E-33 T 13-10-2018 IPR001469 ATP synthase, F1 complex, delta/epsilon subunit GO:0015986|GO:0045261|GO:0046933 Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_1545 e7fd420da9a16555dabe1d3a1e560528 142 Hamap MF_00530 ATP synthase epsilon chain [atpC]. 2 132 22.485 T 13-10-2018 IPR001469 ATP synthase, F1 complex, delta/epsilon subunit GO:0015986|GO:0045261|GO:0046933 Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_1545 e7fd420da9a16555dabe1d3a1e560528 142 Gene3D G3DSA:2.60.15.10 1 88 6.0E-31 T 13-10-2018 IPR036771 F0F1 ATP synthase delta/epsilon subunit, N-terminal Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_1545 e7fd420da9a16555dabe1d3a1e560528 142 Pfam PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 6 82 1.1E-28 T 13-10-2018 IPR020546 ATP synthase, F1 complex, delta/epsilon subunit, N-terminal GO:0015986 Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_1545 e7fd420da9a16555dabe1d3a1e560528 142 Pfam PF00401 ATP synthase, Delta/Epsilon chain, long alpha-helix domain 87 134 2.5E-14 T 13-10-2018 IPR020547 ATP synthase delta/epsilon subunit, C-terminal domain TOPB45_1545 e7fd420da9a16555dabe1d3a1e560528 142 ProDom PD000944 ATP SYNTHASE ION EPSILON SUBUNIT HYDROLASE CF1 SYNTHESIS CHAIN HYDROGEN 9 82 2.0E-21 T 13-10-2018 IPR020546 ATP synthase, F1 complex, delta/epsilon subunit, N-terminal GO:0015986 Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_1545 e7fd420da9a16555dabe1d3a1e560528 142 SUPERFAMILY SSF51344 4 84 7.85E-24 T 13-10-2018 IPR036771 F0F1 ATP synthase delta/epsilon subunit, N-terminal Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_1545 e7fd420da9a16555dabe1d3a1e560528 142 SUPERFAMILY SSF46604 87 137 5.49E-7 T 13-10-2018 IPR036794 ATP synthase delta/epsilon subunit, C-terminal domain superfamily Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_1545 e7fd420da9a16555dabe1d3a1e560528 142 Gene3D G3DSA:1.20.5.440 89 136 8.8E-13 T 13-10-2018 TOPB45_1506 6be936cdf41773de7cf4548c1a815abb 389 Pfam PF13186 Iron-sulfur cluster-binding domain 291 347 7.3E-5 T 13-10-2018 IPR023885 4Fe4S-binding SPASM domain TOPB45_1506 6be936cdf41773de7cf4548c1a815abb 389 PIRSF PIRSF037420 15 389 5.7E-142 T 13-10-2018 IPR017200 Coenzyme PQQ synthesis protein E TOPB45_1506 6be936cdf41773de7cf4548c1a815abb 389 Gene3D G3DSA:3.20.20.70 24 343 7.3E-54 T 13-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 TOPB45_1506 6be936cdf41773de7cf4548c1a815abb 389 Pfam PF13353 4Fe-4S single cluster domain 32 139 2.2E-9 T 13-10-2018 TOPB45_1506 6be936cdf41773de7cf4548c1a815abb 389 TIGRFAM TIGR04085 rSAM_more_4Fe4S: radical SAM additional 4Fe4S-binding SPASM domain 291 374 2.0E-9 T 13-10-2018 IPR023885 4Fe4S-binding SPASM domain TOPB45_1506 6be936cdf41773de7cf4548c1a815abb 389 SMART SM00729 30 236 3.4E-4 T 13-10-2018 IPR006638 Elp3/MiaB/NifB GO:0003824|GO:0051536 TOPB45_1506 6be936cdf41773de7cf4548c1a815abb 389 Pfam PF04055 Radical SAM superfamily 35 190 9.7E-26 T 13-10-2018 IPR007197 Radical SAM GO:0003824|GO:0051536 TOPB45_1506 6be936cdf41773de7cf4548c1a815abb 389 SUPERFAMILY SSF102114 30 354 1.44E-72 T 13-10-2018 TOPB45_0758 0192360fcf2597c76fa57e5c7192ed14 119 Gene3D G3DSA:3.90.470.10 1 119 1.8E-50 T 13-10-2018 IPR036394 Ribosomal protein L22/L17 superfamily GO:0003735|GO:0005840|GO:0006412 TOPB45_0758 0192360fcf2597c76fa57e5c7192ed14 119 Pfam PF00237 Ribosomal protein L22p/L17e 5 107 4.7E-40 T 13-10-2018 IPR001063 Ribosomal protein L22/L17 GO:0003735|GO:0005840|GO:0006412 TOPB45_0758 0192360fcf2597c76fa57e5c7192ed14 119 ProSitePatterns PS00464 Ribosomal protein L22 signature. 83 107 - T 13-10-2018 IPR018260 Ribosomal protein L22/L17, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0758 0192360fcf2597c76fa57e5c7192ed14 119 TIGRFAM TIGR01044 rplV_bact: ribosomal protein uL22 5 107 7.5E-47 T 13-10-2018 IPR005727 Ribosomal protein L22, bacterial/chloroplast-type GO:0003735|GO:0006412|GO:0015934 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0758 0192360fcf2597c76fa57e5c7192ed14 119 Hamap MF_01331_B 50S ribosomal protein L22 [rplV]. 1 110 30.731 T 13-10-2018 IPR005727 Ribosomal protein L22, bacterial/chloroplast-type GO:0003735|GO:0006412|GO:0015934 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0758 0192360fcf2597c76fa57e5c7192ed14 119 SUPERFAMILY SSF54843 2 111 4.06E-47 T 13-10-2018 IPR036394 Ribosomal protein L22/L17 superfamily GO:0003735|GO:0005840|GO:0006412 TOPB45_0045 f069c594e6d7227a140ee0d7bb227f78 117 PRINTS PR01651 Protein-export SecG membrane protein signature 36 52 4.4E-10 T 13-10-2018 IPR004692 Preprotein translocase SecG subunit GO:0009306|GO:0015450|GO:0016021 TOPB45_0045 f069c594e6d7227a140ee0d7bb227f78 117 PRINTS PR01651 Protein-export SecG membrane protein signature 52 74 4.4E-10 T 13-10-2018 IPR004692 Preprotein translocase SecG subunit GO:0009306|GO:0015450|GO:0016021 TOPB45_0045 f069c594e6d7227a140ee0d7bb227f78 117 PRINTS PR01651 Protein-export SecG membrane protein signature 2 22 4.4E-10 T 13-10-2018 IPR004692 Preprotein translocase SecG subunit GO:0009306|GO:0015450|GO:0016021 TOPB45_0045 f069c594e6d7227a140ee0d7bb227f78 117 Pfam PF03840 Preprotein translocase SecG subunit 4 69 6.5E-15 T 13-10-2018 IPR004692 Preprotein translocase SecG subunit GO:0009306|GO:0015450|GO:0016021 TOPB45_0045 f069c594e6d7227a140ee0d7bb227f78 117 TIGRFAM TIGR00810 secG: preprotein translocase, SecG subunit 3 69 3.0E-16 T 13-10-2018 IPR004692 Preprotein translocase SecG subunit GO:0009306|GO:0015450|GO:0016021 TOPB45_0930 4bc8ae7c636a8e417d5993817bdda42f 546 SUPERFAMILY SSF52540 2 502 1.75E-53 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0930 4bc8ae7c636a8e417d5993817bdda42f 546 TIGRFAM TIGR00634 recN: DNA repair protein RecN 2 541 6.6E-147 T 13-10-2018 IPR004604 DNA recombination/repair protein RecN GO:0005524|GO:0006281|GO:0006310 TOPB45_0930 4bc8ae7c636a8e417d5993817bdda42f 546 ProSitePatterns PS00675 Sigma-54 interaction domain ATP-binding region A signature. 25 38 - T 13-10-2018 IPR025662 Sigma-54 interaction domain, ATP-binding site 1 TOPB45_0930 4bc8ae7c636a8e417d5993817bdda42f 546 Pfam PF02463 RecF/RecN/SMC N terminal domain 13 502 5.6E-15 T 13-10-2018 IPR003395 RecF/RecN/SMC, N-terminal TOPB45_0930 4bc8ae7c636a8e417d5993817bdda42f 546 PIRSF PIRSF003128 1 545 1.5E-156 T 13-10-2018 IPR004604 DNA recombination/repair protein RecN GO:0005524|GO:0006281|GO:0006310 TOPB45_0930 4bc8ae7c636a8e417d5993817bdda42f 546 Gene3D G3DSA:3.40.50.300 1 263 1.5E-39 T 13-10-2018 TOPB45_0930 4bc8ae7c636a8e417d5993817bdda42f 546 Gene3D G3DSA:3.40.50.300 264 544 1.9E-53 T 13-10-2018 TOPB45_0120 035936e1a7b61d90909df25ef77857a9 260 Pfam PF13525 Outer membrane lipoprotein 59 242 1.1E-42 T 13-10-2018 IPR039565 Outer membrane lipoprotein BamD-like TOPB45_0120 035936e1a7b61d90909df25ef77857a9 260 Gene3D G3DSA:1.25.40.10 48 254 2.7E-49 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_0120 035936e1a7b61d90909df25ef77857a9 260 TIGRFAM TIGR03302 OM_YfiO: outer membrane assembly lipoprotein YfiO 12 247 1.5E-64 T 13-10-2018 IPR017689 Outer membrane protein assembly factor BamD TOPB45_0120 035936e1a7b61d90909df25ef77857a9 260 Hamap MF_00922 Outer membrane protein assembly factor BamD [bamD]. 12 254 26.7 T 13-10-2018 IPR017689 Outer membrane protein assembly factor BamD TOPB45_0120 035936e1a7b61d90909df25ef77857a9 260 SUPERFAMILY SSF48452 63 172 4.09E-13 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_0398 c9cc038c0a6acbee62c97c054dc10738 735 Pfam PF03063 Prismane/CO dehydrogenase family 125 681 4.7E-112 T 13-10-2018 IPR004137 Hydroxylamine reductase/Ni-containing CO dehydrogenase GO:0016491|GO:0055114 KEGG: 00910+1.7.99.1 TOPB45_0398 c9cc038c0a6acbee62c97c054dc10738 735 Gene3D G3DSA:1.20.1270.30 141 310 1.4E-43 T 13-10-2018 IPR016101 CO dehydrogenase, alpha-bundle GO:0006091|GO:0016151|GO:0018492|GO:0051539|GO:0055114 KEGG: 00633+1.2.7.4|KEGG: 00680+1.2.7.4|KEGG: 00720+1.2.7.4|MetaCyc: PWY-5372|MetaCyc: PWY-6780|MetaCyc: PWY-7784 TOPB45_0398 c9cc038c0a6acbee62c97c054dc10738 735 SUPERFAMILY SSF56821 122 705 4.81E-126 T 13-10-2018 IPR011254 Prismane-like superfamily GO:0003824|GO:0016491|GO:0055114 TOPB45_0398 c9cc038c0a6acbee62c97c054dc10738 735 Gene3D G3DSA:3.40.50.2030 311 479 1.6E-49 T 13-10-2018 IPR016099 Prismane-like, alpha/beta-sandwich GO:0003824|GO:0055114 KEGG: 00910+1.7.99.1 TOPB45_0398 c9cc038c0a6acbee62c97c054dc10738 735 Gene3D G3DSA:3.40.50.2030 483 701 9.7E-64 T 13-10-2018 IPR016099 Prismane-like, alpha/beta-sandwich GO:0003824|GO:0055114 KEGG: 00910+1.7.99.1 TOPB45_1347 74b404ba58b18e852618426323634479 213 SUPERFAMILY SSF102114 28 110 6.15E-16 T 13-10-2018 TOPB45_1347 74b404ba58b18e852618426323634479 213 PIRSF PIRSF000370 2 213 6.3E-60 T 13-10-2018 IPR024924 7-carboxy-7-deazaguanine synthase-like KEGG: 00790+4.3.99.3|MetaCyc: PWY-6703 TOPB45_1347 74b404ba58b18e852618426323634479 213 Hamap MF_00917 7-carboxy-7-deazaguanine synthase [queE]. 4 213 36.498 T 13-10-2018 IPR024924 7-carboxy-7-deazaguanine synthase-like KEGG: 00790+4.3.99.3|MetaCyc: PWY-6703 TOPB45_1347 74b404ba58b18e852618426323634479 213 Pfam PF04055 Radical SAM superfamily 28 115 2.3E-11 T 13-10-2018 IPR007197 Radical SAM GO:0003824|GO:0051536 TOPB45_1347 74b404ba58b18e852618426323634479 213 Gene3D G3DSA:3.20.20.70 3 213 2.0E-42 T 13-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 TOPB45_1347 74b404ba58b18e852618426323634479 213 Pfam PF13394 4Fe-4S single cluster domain 25 121 3.5E-15 T 13-10-2018 TOPB45_1267 5180045b5e3948b753beed3aceb7d389 329 SUPERFAMILY SSF54791 22 72 6.94E-6 T 13-10-2018 IPR036612 K Homology domain, type 1 superfamily GO:0003723 TOPB45_1267 5180045b5e3948b753beed3aceb7d389 329 Gene3D G3DSA:3.40.50.300 115 321 3.8E-76 T 13-10-2018 TOPB45_1267 5180045b5e3948b753beed3aceb7d389 329 SUPERFAMILY SSF52540 60 297 1.66E-39 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1267 5180045b5e3948b753beed3aceb7d389 329 Pfam PF02562 PhoH-like protein 118 321 1.6E-95 T 13-10-2018 IPR003714 PhoH-like protein GO:0005524 TOPB45_0240 05f17afac8b474e7dfaf2b8577209c0d 548 SUPERFAMILY SSF141868 305 547 1.19E-54 T 13-10-2018 IPR035919 EAL domain superfamily TOPB45_0240 05f17afac8b474e7dfaf2b8577209c0d 548 SUPERFAMILY SSF47188 12 119 5.1E-13 T 13-10-2018 IPR035938 Hemerythrin-like superfamily TOPB45_0240 05f17afac8b474e7dfaf2b8577209c0d 548 Gene3D G3DSA:3.20.20.450 298 548 2.7E-55 T 13-10-2018 IPR035919 EAL domain superfamily TOPB45_0240 05f17afac8b474e7dfaf2b8577209c0d 548 SUPERFAMILY SSF55073 130 290 7.77E-23 T 13-10-2018 IPR029787 Nucleotide cyclase TOPB45_0240 05f17afac8b474e7dfaf2b8577209c0d 548 SMART SM00267 114 288 1.5E-7 T 13-10-2018 IPR000160 GGDEF domain TOPB45_0240 05f17afac8b474e7dfaf2b8577209c0d 548 Gene3D G3DSA:3.30.70.270 124 294 6.7E-24 T 13-10-2018 TOPB45_0240 05f17afac8b474e7dfaf2b8577209c0d 548 TIGRFAM TIGR02481 hemeryth_dom: hemerythrin-like metal-binding domain 7 120 4.2E-16 T 13-10-2018 IPR012827 Haemerythrin, metal-binding domain GO:0046872 TOPB45_0240 05f17afac8b474e7dfaf2b8577209c0d 548 SMART SM00052 298 542 9.5E-34 T 13-10-2018 IPR001633 EAL domain TOPB45_0240 05f17afac8b474e7dfaf2b8577209c0d 548 TIGRFAM TIGR00254 GGDEF: diguanylate cyclase (GGDEF) domain 127 287 1.1E-13 T 13-10-2018 IPR000160 GGDEF domain TOPB45_0240 05f17afac8b474e7dfaf2b8577209c0d 548 Pfam PF00990 Diguanylate cyclase, GGDEF domain 127 284 4.1E-17 T 13-10-2018 IPR000160 GGDEF domain TOPB45_0240 05f17afac8b474e7dfaf2b8577209c0d 548 Pfam PF00563 EAL domain 306 537 3.2E-48 T 13-10-2018 IPR001633 EAL domain TOPB45_0240 05f17afac8b474e7dfaf2b8577209c0d 548 Gene3D G3DSA:1.20.120.50 2 123 6.3E-16 T 13-10-2018 IPR035938 Hemerythrin-like superfamily TOPB45_0260 0df02d5e4a0008c5de58f75df347e02b 227 TIGRFAM TIGR00730 TIGR00730: TIGR00730 family protein 49 224 5.3E-50 T 13-10-2018 IPR005269 Cytokinin riboside 5'-monophosphate phosphoribohydrolase LOG TOPB45_0260 0df02d5e4a0008c5de58f75df347e02b 227 Pfam PF03641 Possible lysine decarboxylase 91 221 2.6E-35 T 13-10-2018 IPR031100 LOG family TOPB45_0260 0df02d5e4a0008c5de58f75df347e02b 227 Gene3D G3DSA:3.40.50.450 26 225 9.1E-73 T 13-10-2018 TOPB45_0260 0df02d5e4a0008c5de58f75df347e02b 227 SUPERFAMILY SSF102405 20 222 4.43E-65 T 13-10-2018 TOPB45_0441 9647ab3b053ecfad74029887112fac48 371 Pfam PF12698 ABC-2 family transporter protein 20 362 3.5E-32 T 13-10-2018 TOPB45_0039 cfec1210de6648cdbfffcf3c565d4175 381 Gene3D G3DSA:1.10.287.110 2 112 5.3E-38 T 13-10-2018 IPR036869 Chaperone J-domain superfamily TOPB45_0039 cfec1210de6648cdbfffcf3c565d4175 381 Gene3D G3DSA:2.60.260.20 115 246 2.0E-31 T 13-10-2018 TOPB45_0039 cfec1210de6648cdbfffcf3c565d4175 381 TIGRFAM TIGR02349 DnaJ_bact: chaperone protein DnaJ 5 347 1.4E-120 T 13-10-2018 IPR012724 Chaperone DnaJ GO:0005524|GO:0006457|GO:0009408|GO:0051082 TOPB45_0039 cfec1210de6648cdbfffcf3c565d4175 381 Pfam PF00226 DnaJ domain 5 67 4.6E-32 T 13-10-2018 IPR001623 DnaJ domain TOPB45_0039 cfec1210de6648cdbfffcf3c565d4175 381 Gene3D G3DSA:2.10.230.10 145 205 2.0E-31 T 13-10-2018 TOPB45_0039 cfec1210de6648cdbfffcf3c565d4175 381 SUPERFAMILY SSF49493 111 264 6.93E-16 T 13-10-2018 IPR008971 HSP40/DnaJ peptide-binding GO:0006457|GO:0051082 TOPB45_0039 cfec1210de6648cdbfffcf3c565d4175 381 Hamap MF_01152 Chaperone protein DnaJ [dnaJ]. 2 368 35.416 T 13-10-2018 IPR012724 Chaperone DnaJ GO:0005524|GO:0006457|GO:0009408|GO:0051082 TOPB45_0039 cfec1210de6648cdbfffcf3c565d4175 381 SUPERFAMILY SSF46565 3 98 6.02E-36 T 13-10-2018 IPR036869 Chaperone J-domain superfamily TOPB45_0039 cfec1210de6648cdbfffcf3c565d4175 381 Pfam PF00684 DnaJ central domain 145 205 9.3E-11 T 13-10-2018 IPR001305 Heat shock protein DnaJ, cysteine-rich domain GO:0031072|GO:0051082 TOPB45_0039 cfec1210de6648cdbfffcf3c565d4175 381 PRINTS PR00625 DnaJ domain signature 7 25 1.2E-31 T 13-10-2018 IPR001623 DnaJ domain TOPB45_0039 cfec1210de6648cdbfffcf3c565d4175 381 PRINTS PR00625 DnaJ domain signature 62 81 1.2E-31 T 13-10-2018 IPR001623 DnaJ domain TOPB45_0039 cfec1210de6648cdbfffcf3c565d4175 381 PRINTS PR00625 DnaJ domain signature 25 40 1.2E-31 T 13-10-2018 IPR001623 DnaJ domain TOPB45_0039 cfec1210de6648cdbfffcf3c565d4175 381 PRINTS PR00625 DnaJ domain signature 42 62 1.2E-31 T 13-10-2018 IPR001623 DnaJ domain TOPB45_0039 cfec1210de6648cdbfffcf3c565d4175 381 Pfam PF01556 DnaJ C terminal domain 119 331 3.6E-36 T 13-10-2018 IPR002939 Chaperone DnaJ, C-terminal TOPB45_0039 cfec1210de6648cdbfffcf3c565d4175 381 Gene3D G3DSA:2.60.260.20 252 361 6.9E-26 T 13-10-2018 TOPB45_0039 cfec1210de6648cdbfffcf3c565d4175 381 SMART SM00271 4 62 2.0E-37 T 13-10-2018 IPR001623 DnaJ domain TOPB45_0039 cfec1210de6648cdbfffcf3c565d4175 381 ProSitePatterns PS00636 Nt-dnaJ domain signature. 47 66 - T 13-10-2018 IPR018253 DnaJ domain, conserved site TOPB45_0039 cfec1210de6648cdbfffcf3c565d4175 381 SUPERFAMILY SSF57938 134 209 1.57E-18 T 13-10-2018 IPR036410 Heat shock protein DnaJ, cysteine-rich domain superfamily TOPB45_0039 cfec1210de6648cdbfffcf3c565d4175 381 SUPERFAMILY SSF49493 257 342 2.22E-18 T 13-10-2018 IPR008971 HSP40/DnaJ peptide-binding GO:0006457|GO:0051082 TOPB45_1085 abe52ac462160263ee36b25f90c160ea 117 Pfam PF01909 Nucleotidyltransferase domain 18 94 5.3E-9 T 13-10-2018 IPR002934 Polymerase, nucleotidyl transferase domain GO:0016779 TOPB45_1085 abe52ac462160263ee36b25f90c160ea 117 Gene3D G3DSA:3.30.460.10 4 111 2.8E-21 T 13-10-2018 TOPB45_1085 abe52ac462160263ee36b25f90c160ea 117 SUPERFAMILY SSF81301 13 114 6.31E-16 T 13-10-2018 TOPB45_1413 bf15d9d28e415acc2f29674c2bf86ae5 725 Gene3D G3DSA:3.30.70.260 646 724 8.4E-19 T 13-10-2018 TOPB45_1413 bf15d9d28e415acc2f29674c2bf86ae5 725 SUPERFAMILY SSF81301 182 396 1.49E-62 T 13-10-2018 TOPB45_1413 bf15d9d28e415acc2f29674c2bf86ae5 725 SMART SM00471 41 154 1.1E-10 T 13-10-2018 IPR003607 HD/PDEase domain TOPB45_1413 bf15d9d28e415acc2f29674c2bf86ae5 725 Pfam PF04607 Region found in RelA / SpoT proteins 236 348 5.7E-36 T 13-10-2018 IPR007685 RelA/SpoT GO:0015969 TOPB45_1413 bf15d9d28e415acc2f29674c2bf86ae5 725 SUPERFAMILY SSF81271 379 451 1.96E-24 T 13-10-2018 IPR012676 TGS-like KEGG: 00970+6.1.1.3 TOPB45_1413 bf15d9d28e415acc2f29674c2bf86ae5 725 Gene3D G3DSA:1.10.3210.10 1 191 7.8E-80 T 13-10-2018 TOPB45_1413 bf15d9d28e415acc2f29674c2bf86ae5 725 Gene3D G3DSA:3.30.460.10 193 329 1.2E-49 T 13-10-2018 TOPB45_1413 bf15d9d28e415acc2f29674c2bf86ae5 725 Gene3D G3DSA:3.10.20.30 385 460 1.1E-32 T 13-10-2018 IPR012675 Beta-grasp domain superfamily TOPB45_1413 bf15d9d28e415acc2f29674c2bf86ae5 725 Pfam PF13291 ACT domain 645 722 1.6E-17 T 13-10-2018 IPR002912 ACT domain TOPB45_1413 bf15d9d28e415acc2f29674c2bf86ae5 725 TIGRFAM TIGR00691 spoT_relA: RelA/SpoT family protein 26 721 5.8E-239 T 13-10-2018 IPR004811 RelA/SpoT family GO:0015969 TOPB45_1413 bf15d9d28e415acc2f29674c2bf86ae5 725 Pfam PF13328 HD domain 26 176 3.3E-52 T 13-10-2018 IPR003607 HD/PDEase domain TOPB45_1413 bf15d9d28e415acc2f29674c2bf86ae5 725 SMART SM00954 236 349 1.7E-59 T 13-10-2018 IPR007685 RelA/SpoT GO:0015969 TOPB45_1413 bf15d9d28e415acc2f29674c2bf86ae5 725 SUPERFAMILY SSF109604 3 192 3.51E-72 T 13-10-2018 TOPB45_1413 bf15d9d28e415acc2f29674c2bf86ae5 725 Pfam PF02824 TGS domain 392 449 6.8E-21 T 13-10-2018 IPR004095 TGS KEGG: 00970+6.1.1.3 TOPB45_1413 bf15d9d28e415acc2f29674c2bf86ae5 725 SUPERFAMILY SSF55021 645 724 1.26E-12 T 13-10-2018 TOPB45_1290 320bd0f50746d3b4427fcd13d7dc53a8 243 Pfam PF00005 ABC transporter 21 164 2.5E-26 T 13-10-2018 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TOPB45_1290 320bd0f50746d3b4427fcd13d7dc53a8 243 Gene3D G3DSA:3.40.50.300 1 238 3.3E-54 T 13-10-2018 TOPB45_1290 320bd0f50746d3b4427fcd13d7dc53a8 243 SMART SM00382 30 213 1.9E-8 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_1290 320bd0f50746d3b4427fcd13d7dc53a8 243 SUPERFAMILY SSF52540 4 220 1.95E-54 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0248 0d75b3508f83b21aa59bc1da52da8ded 135 Pfam PF00582 Universal stress protein family 2 132 5.2E-23 T 13-10-2018 IPR006016 UspA TOPB45_0248 0d75b3508f83b21aa59bc1da52da8ded 135 Gene3D G3DSA:3.40.50.620 1 134 5.1E-25 T 13-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TOPB45_0248 0d75b3508f83b21aa59bc1da52da8ded 135 SUPERFAMILY SSF52402 1 133 1.67E-22 T 13-10-2018 TOPB45_0389 b2c63c94477737e7cb59be74ef67e226 619 Gene3D G3DSA:2.40.170.20 164 619 1.2E-105 T 13-10-2018 IPR036942 TonB-dependent receptor-like, beta-barrel domain superfamily TOPB45_0389 b2c63c94477737e7cb59be74ef67e226 619 Pfam PF00593 TonB dependent receptor 200 618 4.5E-54 T 13-10-2018 IPR000531 TonB-dependent receptor-like, beta-barrel TOPB45_0389 b2c63c94477737e7cb59be74ef67e226 619 SUPERFAMILY SSF56935 36 619 2.29E-127 T 13-10-2018 TOPB45_0389 b2c63c94477737e7cb59be74ef67e226 619 Pfam PF07715 TonB-dependent Receptor Plug Domain 48 155 1.9E-25 T 13-10-2018 IPR012910 TonB-dependent receptor, plug domain TOPB45_0389 b2c63c94477737e7cb59be74ef67e226 619 Gene3D G3DSA:2.170.130.10 31 160 5.7E-35 T 13-10-2018 IPR037066 TonB-dependent receptor, plug domain superfamily TOPB45_0133 3062b457bae0c6c00b4e16bb776edf12 270 Pfam PF01113 Dihydrodipicolinate reductase, N-terminus 3 127 3.7E-37 T 13-10-2018 IPR000846 Dihydrodipicolinate reductase, N-terminal GO:0008839|GO:0009089|GO:0055114 KEGG: 00261+1.17.1.8|KEGG: 00300+1.17.1.8|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TOPB45_0133 3062b457bae0c6c00b4e16bb776edf12 270 SUPERFAMILY SSF51735 3 269 6.81E-47 T 13-10-2018 IPR036291 NAD(P)-binding domain superfamily TOPB45_0133 3062b457bae0c6c00b4e16bb776edf12 270 ProSitePatterns PS01298 Dihydrodipicolinate reductase signature. 152 169 - T 13-10-2018 IPR022664 Dihydrodipicolinate reductase, conserved site GO:0008839|GO:0009089|GO:0055114 KEGG: 00261+1.17.1.8|KEGG: 00300+1.17.1.8|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TOPB45_0133 3062b457bae0c6c00b4e16bb776edf12 270 Gene3D G3DSA:3.30.360.10 129 235 3.5E-100 T 13-10-2018 TOPB45_0133 3062b457bae0c6c00b4e16bb776edf12 270 Gene3D G3DSA:3.40.50.720 6 265 3.5E-100 T 13-10-2018 TOPB45_0133 3062b457bae0c6c00b4e16bb776edf12 270 TIGRFAM TIGR00036 dapB: 4-hydroxy-tetrahydrodipicolinate reductase 3 266 6.1E-94 T 13-10-2018 IPR023940 Dihydrodipicolinate reductase GO:0008839|GO:0009089|GO:0055114 KEGG: 00261+1.17.1.8|KEGG: 00300+1.17.1.8|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TOPB45_0133 3062b457bae0c6c00b4e16bb776edf12 270 Hamap MF_00102 4-hydroxy-tetrahydrodipicolinate reductase [dapB]. 3 266 34.143 T 13-10-2018 IPR023940 Dihydrodipicolinate reductase GO:0008839|GO:0009089|GO:0055114 KEGG: 00261+1.17.1.8|KEGG: 00300+1.17.1.8|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TOPB45_0133 3062b457bae0c6c00b4e16bb776edf12 270 Pfam PF05173 Dihydrodipicolinate reductase, C-terminus 130 265 3.4E-46 T 13-10-2018 IPR022663 Dihydrodipicolinate reductase, C-terminal GO:0008839|GO:0009089|GO:0055114 KEGG: 00261+1.17.1.8|KEGG: 00300+1.17.1.8|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TOPB45_0133 3062b457bae0c6c00b4e16bb776edf12 270 SUPERFAMILY SSF55347 129 237 3.92E-34 T 13-10-2018 TOPB45_0133 3062b457bae0c6c00b4e16bb776edf12 270 PIRSF PIRSF000161 1 269 3.5E-86 T 13-10-2018 IPR023940 Dihydrodipicolinate reductase GO:0008839|GO:0009089|GO:0055114 KEGG: 00261+1.17.1.8|KEGG: 00300+1.17.1.8|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TOPB45_0218 48b278ca312958dd5e293f064cc14942 557 Gene3D G3DSA:3.30.1370.100 421 512 2.0E-40 T 13-10-2018 TOPB45_0218 48b278ca312958dd5e293f064cc14942 557 Pfam PF08676 MutL C terminal dimerisation domain 381 513 5.8E-24 T 13-10-2018 IPR014790 MutL, C-terminal, dimerisation GO:0005524|GO:0006298 TOPB45_0218 48b278ca312958dd5e293f064cc14942 557 Hamap MF_00149 DNA mismatch repair protein MutL [mutL]. 2 554 21.202 T 13-10-2018 IPR020667 DNA mismatch repair protein, MutL GO:0006298 TOPB45_0218 48b278ca312958dd5e293f064cc14942 557 TIGRFAM TIGR00585 mutl: DNA mismatch repair protein MutL 3 309 7.7E-80 T 13-10-2018 IPR002099 DNA mismatch repair protein family, N-terminal GO:0005524|GO:0006298|GO:0030983 TOPB45_0218 48b278ca312958dd5e293f064cc14942 557 Gene3D G3DSA:3.30.565.10 2 203 1.8E-57 T 13-10-2018 IPR036890 Histidine kinase/HSP90-like ATPase superfamily TOPB45_0218 48b278ca312958dd5e293f064cc14942 557 SMART SM00853 381 515 7.9E-20 T 13-10-2018 IPR014790 MutL, C-terminal, dimerisation GO:0005524|GO:0006298 TOPB45_0218 48b278ca312958dd5e293f064cc14942 557 SUPERFAMILY SSF55874 2 216 2.36E-45 T 13-10-2018 IPR036890 Histidine kinase/HSP90-like ATPase superfamily TOPB45_0218 48b278ca312958dd5e293f064cc14942 557 Pfam PF01119 DNA mismatch repair protein, C-terminal domain 239 327 2.2E-18 T 13-10-2018 IPR013507 DNA mismatch repair protein, S5 domain 2-like GO:0005524|GO:0006298|GO:0030983 TOPB45_0218 48b278ca312958dd5e293f064cc14942 557 SMART SM01340 212 329 1.7E-20 T 13-10-2018 IPR013507 DNA mismatch repair protein, S5 domain 2-like GO:0005524|GO:0006298|GO:0030983 TOPB45_0218 48b278ca312958dd5e293f064cc14942 557 Pfam PF13589 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 25 129 2.1E-14 T 13-10-2018 TOPB45_0218 48b278ca312958dd5e293f064cc14942 557 ProSitePatterns PS00058 DNA mismatch repair proteins mutL / hexB / PMS1 signature. 94 100 - T 13-10-2018 IPR014762 DNA mismatch repair, conserved site TOPB45_0218 48b278ca312958dd5e293f064cc14942 557 SUPERFAMILY SSF118116 377 556 2.75E-33 T 13-10-2018 IPR037198 MutL, C-terminal domain superfamily TOPB45_0218 48b278ca312958dd5e293f064cc14942 557 Gene3D G3DSA:3.30.230.10 223 327 2.6E-19 T 13-10-2018 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup TOPB45_0218 48b278ca312958dd5e293f064cc14942 557 SUPERFAMILY SSF54211 202 329 3.07E-19 T 13-10-2018 IPR020568 Ribosomal protein S5 domain 2-type fold TOPB45_0218 48b278ca312958dd5e293f064cc14942 557 Gene3D G3DSA:2.30.42.20 382 556 2.0E-40 T 13-10-2018 TOPB45_1463 cee5a3dacf9054f3b3ca7312970e471a 190 Gene3D G3DSA:3.40.50.1950 3 189 9.0E-69 T 13-10-2018 IPR036551 Flavin prenyltransferase-like GO:0003824 Reactome: R-HSA-196783 TOPB45_1463 cee5a3dacf9054f3b3ca7312970e471a 190 Pfam PF02441 Flavoprotein 3 165 9.0E-27 T 13-10-2018 IPR003382 Flavoprotein GO:0003824 Reactome: R-HSA-196783 TOPB45_1463 cee5a3dacf9054f3b3ca7312970e471a 190 TIGRFAM TIGR00421 ubiX_pad: polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases 4 184 6.9E-63 T 13-10-2018 IPR004507 Flavin prenyltransferase UbiX-like TOPB45_1463 cee5a3dacf9054f3b3ca7312970e471a 190 SUPERFAMILY SSF52507 3 186 4.32E-53 T 13-10-2018 IPR036551 Flavin prenyltransferase-like GO:0003824 Reactome: R-HSA-196783 TOPB45_1463 cee5a3dacf9054f3b3ca7312970e471a 190 Hamap MF_01984 Flavin prenyltransferase UbiX [ubiX]. 3 186 31.363 T 13-10-2018 IPR004507 Flavin prenyltransferase UbiX-like TOPB45_1371 6afed77d129e282558d9d0a158c53b5e 390 SUPERFAMILY SSF88697 4 73 8.95E-8 T 13-10-2018 IPR015947 PUA-like superfamily TOPB45_1371 6afed77d129e282558d9d0a158c53b5e 390 SUPERFAMILY SSF53335 83 384 9.6E-51 T 13-10-2018 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TOPB45_1371 6afed77d129e282558d9d0a158c53b5e 390 Gene3D G3DSA:3.30.750.80 76 181 4.1E-33 T 13-10-2018 TOPB45_1371 6afed77d129e282558d9d0a158c53b5e 390 Pfam PF10672 S-adenosylmethionine-dependent methyltransferase 111 302 1.7E-13 T 13-10-2018 IPR019614 S-adenosylmethionine-dependent methyltransferase GO:0008168 TOPB45_1371 6afed77d129e282558d9d0a158c53b5e 390 Gene3D G3DSA:2.30.130.10 5 74 2.0E-13 T 13-10-2018 IPR036974 PUA domain superfamily GO:0003723 TOPB45_1371 6afed77d129e282558d9d0a158c53b5e 390 Gene3D G3DSA:3.40.50.150 183 390 1.0E-43 T 13-10-2018 TOPB45_1296 9b14e1ed065f4f7a0677ee956c60f137 335 PIRSF PIRSF000089 12 335 7.4E-83 T 13-10-2018 IPR001308 Electron transfer flavoprotein alpha subunit/FixB GO:0009055|GO:0050660 Reactome: R-HSA-611105 TOPB45_1296 9b14e1ed065f4f7a0677ee956c60f137 335 Gene3D G3DSA:3.40.50.620 12 195 8.0E-36 T 13-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TOPB45_1296 9b14e1ed065f4f7a0677ee956c60f137 335 Pfam PF01012 Electron transfer flavoprotein domain 23 176 3.5E-23 T 13-10-2018 IPR014730 Electron transfer flavoprotein, alpha/beta-subunit, N-terminal Reactome: R-HSA-611105 TOPB45_1296 9b14e1ed065f4f7a0677ee956c60f137 335 SMART SM00893 15 198 2.1E-10 T 13-10-2018 IPR014730 Electron transfer flavoprotein, alpha/beta-subunit, N-terminal Reactome: R-HSA-611105 TOPB45_1296 9b14e1ed065f4f7a0677ee956c60f137 335 Pfam PF00766 Electron transfer flavoprotein FAD-binding domain 214 296 2.6E-33 T 13-10-2018 IPR014731 Electron transfer flavoprotein, alpha subunit, C-terminal Reactome: R-HSA-611105 TOPB45_1296 9b14e1ed065f4f7a0677ee956c60f137 335 SUPERFAMILY SSF52402 14 193 3.35E-28 T 13-10-2018 TOPB45_1296 9b14e1ed065f4f7a0677ee956c60f137 335 Gene3D G3DSA:3.40.50.1220 208 335 2.0E-48 T 13-10-2018 TOPB45_1296 9b14e1ed065f4f7a0677ee956c60f137 335 SUPERFAMILY SSF52467 214 333 1.25E-41 T 13-10-2018 IPR029035 DHS-like NAD/FAD-binding domain superfamily TOPB45_1383 b2be04b0dad9b61c048b2e763d8acbce 148 Hamap MF_00073 Transcription antitermination protein NusB [nusB]. 1 135 22.593 T 13-10-2018 IPR011605 NusB antitermination factor GO:0006353 TOPB45_1383 b2be04b0dad9b61c048b2e763d8acbce 148 Pfam PF01029 NusB family 5 132 1.1E-34 T 13-10-2018 IPR006027 NusB/RsmB/TIM44 GO:0003723|GO:0006355 TOPB45_1383 b2be04b0dad9b61c048b2e763d8acbce 148 SUPERFAMILY SSF48013 2 133 6.54E-40 T 13-10-2018 IPR035926 NusB-like superfamily TOPB45_1383 b2be04b0dad9b61c048b2e763d8acbce 148 TIGRFAM TIGR01951 nusB: transcription antitermination factor NusB 2 133 1.2E-42 T 13-10-2018 IPR011605 NusB antitermination factor GO:0006353 TOPB45_1383 b2be04b0dad9b61c048b2e763d8acbce 148 Gene3D G3DSA:1.10.940.10 1 147 6.7E-44 T 13-10-2018 IPR035926 NusB-like superfamily TOPB45_0460 e56adf7c5edfa3c8a700532063b37a4b 1015 SUPERFAMILY SSF141868 777 1012 8.37E-72 T 13-10-2018 IPR035919 EAL domain superfamily TOPB45_0460 e56adf7c5edfa3c8a700532063b37a4b 1015 Pfam PF00563 EAL domain 778 1003 1.5E-59 T 13-10-2018 IPR001633 EAL domain TOPB45_0460 e56adf7c5edfa3c8a700532063b37a4b 1015 Gene3D G3DSA:3.20.20.450 774 1014 1.2E-74 T 13-10-2018 IPR035919 EAL domain superfamily TOPB45_0460 e56adf7c5edfa3c8a700532063b37a4b 1015 TIGRFAM TIGR00254 GGDEF: diguanylate cyclase (GGDEF) domain 601 757 2.5E-23 T 13-10-2018 IPR000160 GGDEF domain TOPB45_0460 e56adf7c5edfa3c8a700532063b37a4b 1015 Pfam PF00990 Diguanylate cyclase, GGDEF domain 603 752 1.2E-30 T 13-10-2018 IPR000160 GGDEF domain TOPB45_0460 e56adf7c5edfa3c8a700532063b37a4b 1015 Gene3D G3DSA:3.30.70.270 598 773 4.9E-36 T 13-10-2018 TOPB45_0460 e56adf7c5edfa3c8a700532063b37a4b 1015 SUPERFAMILY SSF55785 500 597 5.41E-7 T 13-10-2018 IPR035965 PAS domain superfamily TOPB45_0460 e56adf7c5edfa3c8a700532063b37a4b 1015 SUPERFAMILY SSF55785 249 348 4.89E-12 T 13-10-2018 IPR035965 PAS domain superfamily TOPB45_0460 e56adf7c5edfa3c8a700532063b37a4b 1015 SUPERFAMILY SSF55073 607 760 3.69E-34 T 13-10-2018 IPR029787 Nucleotide cyclase TOPB45_0460 e56adf7c5edfa3c8a700532063b37a4b 1015 Gene3D G3DSA:3.30.450.20 230 365 4.8E-11 T 13-10-2018 TOPB45_0460 e56adf7c5edfa3c8a700532063b37a4b 1015 Pfam PF13426 PAS domain 249 348 3.9E-7 T 13-10-2018 IPR000014 PAS domain TOPB45_0460 e56adf7c5edfa3c8a700532063b37a4b 1015 Pfam PF13426 PAS domain 501 589 1.3E-4 T 13-10-2018 IPR000014 PAS domain TOPB45_0460 e56adf7c5edfa3c8a700532063b37a4b 1015 SMART SM00091 488 555 1.8 T 13-10-2018 IPR000014 PAS domain TOPB45_0460 e56adf7c5edfa3c8a700532063b37a4b 1015 SMART SM00091 232 301 0.5 T 13-10-2018 IPR000014 PAS domain TOPB45_0460 e56adf7c5edfa3c8a700532063b37a4b 1015 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 252 354 4.9E-14 T 13-10-2018 IPR000014 PAS domain TOPB45_0460 e56adf7c5edfa3c8a700532063b37a4b 1015 Gene3D G3DSA:3.30.450.20 480 597 3.6E-8 T 13-10-2018 TOPB45_0460 e56adf7c5edfa3c8a700532063b37a4b 1015 SMART SM00267 591 759 5.5E-26 T 13-10-2018 IPR000160 GGDEF domain TOPB45_0460 e56adf7c5edfa3c8a700532063b37a4b 1015 SMART SM00052 769 1008 1.2E-69 T 13-10-2018 IPR001633 EAL domain TOPB45_0460 e56adf7c5edfa3c8a700532063b37a4b 1015 SUPERFAMILY SSF55781 346 478 6.54E-6 T 13-10-2018 TOPB45_0010 406e5ee202d0a701ee98c2d6d3fba7ce 253 Pfam PF01478 Type IV leader peptidase family 105 214 2.2E-17 T 13-10-2018 IPR000045 Prepilin type IV endopeptidase, peptidase domain GO:0004190|GO:0016020 TOPB45_0010 406e5ee202d0a701ee98c2d6d3fba7ce 253 Gene3D G3DSA:1.20.120.1220 95 227 2.5E-7 T 13-10-2018 TOPB45_0010 406e5ee202d0a701ee98c2d6d3fba7ce 253 Pfam PF06750 Bacterial Peptidase A24 N-terminal domain 7 91 1.3E-31 T 13-10-2018 IPR010627 Peptidase A24A, N-terminal TOPB45_0010 406e5ee202d0a701ee98c2d6d3fba7ce 253 PRINTS PR00864 Type IV prepilin cysteine protease (C20) family signature 113 130 1.4E-8 T 13-10-2018 IPR014032 Peptidase A24A, prepilin type IV, bacterial TOPB45_0010 406e5ee202d0a701ee98c2d6d3fba7ce 253 PRINTS PR00864 Type IV prepilin cysteine protease (C20) family signature 172 182 1.4E-8 T 13-10-2018 IPR014032 Peptidase A24A, prepilin type IV, bacterial TOPB45_0010 406e5ee202d0a701ee98c2d6d3fba7ce 253 PRINTS PR00864 Type IV prepilin cysteine protease (C20) family signature 183 194 1.4E-8 T 13-10-2018 IPR014032 Peptidase A24A, prepilin type IV, bacterial TOPB45_0010 406e5ee202d0a701ee98c2d6d3fba7ce 253 PRINTS PR00864 Type IV prepilin cysteine protease (C20) family signature 195 210 1.4E-8 T 13-10-2018 IPR014032 Peptidase A24A, prepilin type IV, bacterial TOPB45_0132 dc7553f77a08d1542e21093b273523dd 403 Pfam PF00149 Calcineurin-like phosphoesterase 1 231 8.8E-14 T 13-10-2018 IPR004843 Calcineurin-like phosphoesterase domain, ApaH type GO:0016787 TOPB45_0132 dc7553f77a08d1542e21093b273523dd 403 Pfam PF12320 Type 5 capsule protein repressor C-terminal domain 282 370 3.0E-7 T 13-10-2018 IPR026843 Nuclease SbcCD subunit D, C-terminal domain TOPB45_0132 dc7553f77a08d1542e21093b273523dd 403 Gene3D G3DSA:3.60.21.10 1 277 1.4E-51 T 13-10-2018 IPR029052 Metallo-dependent phosphatase-like TOPB45_0132 dc7553f77a08d1542e21093b273523dd 403 TIGRFAM TIGR00619 sbcd: exonuclease SbcCD, D subunit 1 257 6.1E-32 T 13-10-2018 IPR004593 Nuclease SbcCD subunit D GO:0004519|GO:0006259|GO:0008408 TOPB45_0132 dc7553f77a08d1542e21093b273523dd 403 SUPERFAMILY SSF56300 1 314 3.04E-38 T 13-10-2018 TOPB45_0949 4dec381c268472cbc6437f715f142f33 261 Pfam PF02195 ParB-like nuclease domain 33 92 5.4E-12 T 13-10-2018 IPR003115 ParB/Sulfiredoxin TOPB45_0949 4dec381c268472cbc6437f715f142f33 261 Gene3D G3DSA:3.90.1530.10 4 99 7.9E-8 T 13-10-2018 TOPB45_0949 4dec381c268472cbc6437f715f142f33 261 SMART SM00470 19 107 6.3E-8 T 13-10-2018 IPR003115 ParB/Sulfiredoxin TOPB45_0949 4dec381c268472cbc6437f715f142f33 261 SUPERFAMILY SSF110849 18 94 2.22E-14 T 13-10-2018 IPR036086 ParB/Sulfiredoxin superfamily TOPB45_1161 cdf59af51702bd9c110309db5f06413d 702 Gene3D G3DSA:3.30.230.70 233 546 4.2E-117 T 13-10-2018 IPR027408 PNPase/RNase PH domain superfamily Reactome: R-HSA-380994|Reactome: R-HSA-429958|Reactome: R-HSA-450385|Reactome: R-HSA-450513|Reactome: R-HSA-450604|Reactome: R-HSA-6791226 TOPB45_1161 cdf59af51702bd9c110309db5f06413d 702 SMART SM00316 617 686 1.3E-19 T 13-10-2018 IPR022967 RNA-binding domain, S1 TOPB45_1161 cdf59af51702bd9c110309db5f06413d 702 Pfam PF00013 KH domain 554 610 1.3E-11 T 13-10-2018 IPR004088 K Homology domain, type 1 GO:0003723 TOPB45_1161 cdf59af51702bd9c110309db5f06413d 702 SUPERFAMILY SSF55666 136 229 1.83E-24 T 13-10-2018 IPR036345 Exoribonuclease, PH domain 2 superfamily Reactome: R-HSA-380994|Reactome: R-HSA-429958|Reactome: R-HSA-450385|Reactome: R-HSA-450513|Reactome: R-HSA-450604|Reactome: R-HSA-6791226 TOPB45_1161 cdf59af51702bd9c110309db5f06413d 702 Pfam PF03726 Polyribonucleotide nucleotidyltransferase, RNA binding domain 240 316 6.0E-13 T 13-10-2018 IPR015848 Polyribonucleotide nucleotidyltransferase, RNA-binding domain GO:0003723|GO:0006396 KEGG: 00230+2.7.7.8|KEGG: 00240+2.7.7.8 TOPB45_1161 cdf59af51702bd9c110309db5f06413d 702 SUPERFAMILY SSF46915 237 316 2.25E-13 T 13-10-2018 IPR036456 Polyribonucleotide nucleotidyltransferase, RNA-binding domain superfamily GO:0003723|GO:0006396 KEGG: 00230+2.7.7.8|KEGG: 00240+2.7.7.8 TOPB45_1161 cdf59af51702bd9c110309db5f06413d 702 PIRSF PIRSF005499 1 697 8.3E-282 T 13-10-2018 IPR012162 Polyribonucleotide nucleotidyltransferase GO:0003723|GO:0004654|GO:0006402 KEGG: 00230+2.7.7.8|KEGG: 00240+2.7.7.8 TOPB45_1161 cdf59af51702bd9c110309db5f06413d 702 Gene3D G3DSA:3.30.230.70 1 226 5.3E-75 T 13-10-2018 IPR027408 PNPase/RNase PH domain superfamily Reactome: R-HSA-380994|Reactome: R-HSA-429958|Reactome: R-HSA-450385|Reactome: R-HSA-450513|Reactome: R-HSA-450604|Reactome: R-HSA-6791226 TOPB45_1161 cdf59af51702bd9c110309db5f06413d 702 Pfam PF01138 3' exoribonuclease family, domain 1 13 142 5.9E-16 T 13-10-2018 IPR001247 Exoribonuclease, phosphorolytic domain 1 Reactome: R-HSA-380994|Reactome: R-HSA-429958|Reactome: R-HSA-450385|Reactome: R-HSA-450513|Reactome: R-HSA-450604|Reactome: R-HSA-6791226 TOPB45_1161 cdf59af51702bd9c110309db5f06413d 702 Pfam PF01138 3' exoribonuclease family, domain 1 319 453 4.4E-25 T 13-10-2018 IPR001247 Exoribonuclease, phosphorolytic domain 1 Reactome: R-HSA-380994|Reactome: R-HSA-429958|Reactome: R-HSA-450385|Reactome: R-HSA-450513|Reactome: R-HSA-450604|Reactome: R-HSA-6791226 TOPB45_1161 cdf59af51702bd9c110309db5f06413d 702 SMART SM00322 549 614 2.6E-12 T 13-10-2018 IPR004087 K Homology domain GO:0003676 TOPB45_1161 cdf59af51702bd9c110309db5f06413d 702 SUPERFAMILY SSF55666 447 546 8.12E-28 T 13-10-2018 IPR036345 Exoribonuclease, PH domain 2 superfamily Reactome: R-HSA-380994|Reactome: R-HSA-429958|Reactome: R-HSA-450385|Reactome: R-HSA-450513|Reactome: R-HSA-450604|Reactome: R-HSA-6791226 TOPB45_1161 cdf59af51702bd9c110309db5f06413d 702 Pfam PF03725 3' exoribonuclease family, domain 2 458 526 2.4E-6 T 13-10-2018 IPR015847 Exoribonuclease, phosphorolytic domain 2 Reactome: R-HSA-380994|Reactome: R-HSA-429958|Reactome: R-HSA-450385|Reactome: R-HSA-450513|Reactome: R-HSA-450604|Reactome: R-HSA-6791226 TOPB45_1161 cdf59af51702bd9c110309db5f06413d 702 Pfam PF03725 3' exoribonuclease family, domain 2 146 207 4.3E-14 T 13-10-2018 IPR015847 Exoribonuclease, phosphorolytic domain 2 Reactome: R-HSA-380994|Reactome: R-HSA-429958|Reactome: R-HSA-450385|Reactome: R-HSA-450513|Reactome: R-HSA-450604|Reactome: R-HSA-6791226 TOPB45_1161 cdf59af51702bd9c110309db5f06413d 702 SUPERFAMILY SSF54211 292 485 2.13E-49 T 13-10-2018 IPR020568 Ribosomal protein S5 domain 2-type fold TOPB45_1161 cdf59af51702bd9c110309db5f06413d 702 SUPERFAMILY SSF54791 552 637 1.64E-19 T 13-10-2018 IPR036612 K Homology domain, type 1 superfamily GO:0003723 TOPB45_1161 cdf59af51702bd9c110309db5f06413d 702 TIGRFAM TIGR03591 polynuc_phos: polyribonucleotide nucleotidyltransferase 13 686 2.6E-269 T 13-10-2018 IPR012162 Polyribonucleotide nucleotidyltransferase GO:0003723|GO:0004654|GO:0006402 KEGG: 00230+2.7.7.8|KEGG: 00240+2.7.7.8 TOPB45_1161 cdf59af51702bd9c110309db5f06413d 702 SUPERFAMILY SSF54211 14 142 1.92E-43 T 13-10-2018 IPR020568 Ribosomal protein S5 domain 2-type fold TOPB45_1161 cdf59af51702bd9c110309db5f06413d 702 SUPERFAMILY SSF50249 616 686 7.49E-13 T 13-10-2018 IPR012340 Nucleic acid-binding, OB-fold TOPB45_1161 cdf59af51702bd9c110309db5f06413d 702 Pfam PF00575 S1 RNA binding domain 616 684 6.4E-13 T 13-10-2018 IPR003029 S1 domain GO:0003676 TOPB45_1161 cdf59af51702bd9c110309db5f06413d 702 Gene3D G3DSA:3.30.1370.10 547 618 3.2E-20 T 13-10-2018 IPR036612 K Homology domain, type 1 superfamily GO:0003723 TOPB45_1161 cdf59af51702bd9c110309db5f06413d 702 Gene3D G3DSA:2.40.50.140 619 688 3.1E-16 T 13-10-2018 TOPB45_1161 cdf59af51702bd9c110309db5f06413d 702 Hamap MF_01595 Polyribonucleotide nucleotidyltransferase [pnp]. 2 689 27.847 T 13-10-2018 IPR012162 Polyribonucleotide nucleotidyltransferase GO:0003723|GO:0004654|GO:0006402 KEGG: 00230+2.7.7.8|KEGG: 00240+2.7.7.8 TOPB45_0407 12061776cea2c7abc472710362212f88 172 SUPERFAMILY SSF52499 2 166 5.23E-56 T 13-10-2018 IPR036380 Isochorismatase-like superfamily GO:0003824 TOPB45_0407 12061776cea2c7abc472710362212f88 172 Gene3D G3DSA:3.40.50.850 1 171 9.3E-58 T 13-10-2018 IPR036380 Isochorismatase-like superfamily GO:0003824 TOPB45_0407 12061776cea2c7abc472710362212f88 172 Pfam PF00857 Isochorismatase family 3 164 1.3E-44 T 13-10-2018 IPR000868 Isochorismatase-like GO:0003824 TOPB45_0407 12061776cea2c7abc472710362212f88 172 PRINTS PR01398 Isochorismatase signature 36 53 4.1E-7 T 13-10-2018 IPR016291 Isochorismatase GO:0008908 TOPB45_0407 12061776cea2c7abc472710362212f88 172 PRINTS PR01398 Isochorismatase signature 137 155 4.1E-7 T 13-10-2018 IPR016291 Isochorismatase GO:0008908 TOPB45_0407 12061776cea2c7abc472710362212f88 172 PRINTS PR01398 Isochorismatase signature 81 103 4.1E-7 T 13-10-2018 IPR016291 Isochorismatase GO:0008908 TOPB45_1435 5779d9803327c9467b1581932d50c1bc 226 SMART SM00986 67 213 7.6E-21 T 13-10-2018 IPR005122 Uracil-DNA glycosylase-like Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 TOPB45_1435 5779d9803327c9467b1581932d50c1bc 226 SMART SM00987 67 213 7.6E-21 T 13-10-2018 TOPB45_1435 5779d9803327c9467b1581932d50c1bc 226 SUPERFAMILY SSF52141 42 222 5.56E-49 T 13-10-2018 IPR036895 Uracil-DNA glycosylase-like domain superfamily Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 TOPB45_1435 5779d9803327c9467b1581932d50c1bc 226 TIGRFAM TIGR00758 UDG_fam4: uracil-DNA glycosylase, family 4 53 218 4.5E-43 T 13-10-2018 IPR005273 Uracil-DNA glycosylase family 4 TOPB45_1435 5779d9803327c9467b1581932d50c1bc 226 Pfam PF03167 Uracil DNA glycosylase superfamily 67 213 4.0E-31 T 13-10-2018 IPR005122 Uracil-DNA glycosylase-like Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 TOPB45_1435 5779d9803327c9467b1581932d50c1bc 226 Gene3D G3DSA:3.40.470.10 41 225 3.1E-54 T 13-10-2018 IPR036895 Uracil-DNA glycosylase-like domain superfamily Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 TOPB45_0214 adceafcc97811a125d43366f7cf4fbd7 454 Gene3D G3DSA:3.40.120.10 2 149 5.2E-52 T 13-10-2018 TOPB45_0214 adceafcc97811a125d43366f7cf4fbd7 454 SUPERFAMILY SSF53738 151 252 1.26E-30 T 13-10-2018 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TOPB45_0214 adceafcc97811a125d43366f7cf4fbd7 454 Pfam PF02880 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III 255 366 1.1E-27 T 13-10-2018 IPR005846 Alpha-D-phosphohexomutase, alpha/beta/alpha domain III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TOPB45_0214 adceafcc97811a125d43366f7cf4fbd7 454 Pfam PF00408 Phosphoglucomutase/phosphomannomutase, C-terminal domain 370 447 8.3E-13 T 13-10-2018 IPR005843 Alpha-D-phosphohexomutase, C-terminal GO:0016868|GO:0071704 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TOPB45_0214 adceafcc97811a125d43366f7cf4fbd7 454 SUPERFAMILY SSF53738 254 361 6.67E-36 T 13-10-2018 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TOPB45_0214 adceafcc97811a125d43366f7cf4fbd7 454 Pfam PF02879 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II 153 250 8.0E-24 T 13-10-2018 IPR005845 Alpha-D-phosphohexomutase, alpha/beta/alpha domain II GO:0005975 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TOPB45_0214 adceafcc97811a125d43366f7cf4fbd7 454 Gene3D G3DSA:3.40.120.10 169 246 2.0E-28 T 13-10-2018 TOPB45_0214 adceafcc97811a125d43366f7cf4fbd7 454 SUPERFAMILY SSF53738 4 136 1.5E-37 T 13-10-2018 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TOPB45_0214 adceafcc97811a125d43366f7cf4fbd7 454 Pfam PF02878 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I 7 138 4.0E-35 T 13-10-2018 IPR005844 Alpha-D-phosphohexomutase, alpha/beta/alpha domain I GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TOPB45_0214 adceafcc97811a125d43366f7cf4fbd7 454 Gene3D G3DSA:3.40.120.10 247 365 1.8E-42 T 13-10-2018 TOPB45_0214 adceafcc97811a125d43366f7cf4fbd7 454 Gene3D G3DSA:3.30.310.50 366 454 5.1E-28 T 13-10-2018 TOPB45_0214 adceafcc97811a125d43366f7cf4fbd7 454 SUPERFAMILY SSF55957 363 452 3.14E-26 T 13-10-2018 IPR036900 Alpha-D-phosphohexomutase, C-terminal domain superfamily GO:0016868|GO:0071704 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TOPB45_0214 adceafcc97811a125d43366f7cf4fbd7 454 PRINTS PR00509 Phosphoglucomutase/phosphomannomutase family signature 230 245 2.3E-19 T 13-10-2018 IPR005841 Alpha-D-phosphohexomutase superfamily GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TOPB45_0214 adceafcc97811a125d43366f7cf4fbd7 454 PRINTS PR00509 Phosphoglucomutase/phosphomannomutase family signature 96 110 2.3E-19 T 13-10-2018 IPR005841 Alpha-D-phosphohexomutase superfamily GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TOPB45_0214 adceafcc97811a125d43366f7cf4fbd7 454 PRINTS PR00509 Phosphoglucomutase/phosphomannomutase family signature 201 214 2.3E-19 T 13-10-2018 IPR005841 Alpha-D-phosphohexomutase superfamily GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TOPB45_0214 adceafcc97811a125d43366f7cf4fbd7 454 PRINTS PR00509 Phosphoglucomutase/phosphomannomutase family signature 167 186 2.3E-19 T 13-10-2018 IPR005841 Alpha-D-phosphohexomutase superfamily GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TOPB45_0214 adceafcc97811a125d43366f7cf4fbd7 454 ProSitePatterns PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 97 106 - T 13-10-2018 IPR016066 Alpha-D-phosphohexomutase, conserved site GO:0000287 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 TOPB45_1345 acbe480203d248027ceaf8970298f22b 509 Gene3D G3DSA:2.30.220.10 192 295 4.2E-91 T 13-10-2018 TOPB45_1345 acbe480203d248027ceaf8970298f22b 509 Gene3D G3DSA:1.20.1330.10 45 468 4.2E-91 T 13-10-2018 TOPB45_1345 acbe480203d248027ceaf8970298f22b 509 Gene3D G3DSA:2.170.280.10 178 416 4.2E-91 T 13-10-2018 TOPB45_1345 acbe480203d248027ceaf8970298f22b 509 Pfam PF00669 Bacterial flagellin N-terminal helical region 5 143 1.5E-27 T 13-10-2018 IPR001029 Flagellin, D0/D1 domain GO:0005198|GO:0071973 TOPB45_1345 acbe480203d248027ceaf8970298f22b 509 Gene3D G3DSA:1.20.58.1830 5 508 4.2E-91 T 13-10-2018 TOPB45_1345 acbe480203d248027ceaf8970298f22b 509 PRINTS PR00207 Flagellin signature 37 54 2.7E-9 T 13-10-2018 IPR001492 Flagellin GO:0005198|GO:0009420|GO:0071973 TOPB45_1345 acbe480203d248027ceaf8970298f22b 509 PRINTS PR00207 Flagellin signature 111 134 2.7E-9 T 13-10-2018 IPR001492 Flagellin GO:0005198|GO:0009420|GO:0071973 TOPB45_1345 acbe480203d248027ceaf8970298f22b 509 PRINTS PR00207 Flagellin signature 76 95 2.7E-9 T 13-10-2018 IPR001492 Flagellin GO:0005198|GO:0009420|GO:0071973 TOPB45_1345 acbe480203d248027ceaf8970298f22b 509 SUPERFAMILY SSF64518 1 509 4.05E-67 T 13-10-2018 TOPB45_1345 acbe480203d248027ceaf8970298f22b 509 Pfam PF00700 Bacterial flagellin C-terminal helical region 423 508 1.9E-19 T 13-10-2018 IPR001029 Flagellin, D0/D1 domain GO:0005198|GO:0071973 TOPB45_0368 94e05db48b9fcdd2a62b22bc8d0fd37a 81 Pfam PF04945 YHS domain 41 74 7.9E-9 T 13-10-2018 IPR007029 YHS domain TOPB45_0368 94e05db48b9fcdd2a62b22bc8d0fd37a 81 SMART SM00746 39 76 3.7E-6 T 13-10-2018 IPR011017 TRASH domain TOPB45_0842 147695cea4a9b770780c1aff3bad9d24 213 Pfam PF10294 Lysine methyltransferase 49 171 4.3E-17 T 13-10-2018 IPR019410 Lysine methyltransferase TOPB45_0842 147695cea4a9b770780c1aff3bad9d24 213 Gene3D G3DSA:3.40.50.150 39 204 6.5E-34 T 13-10-2018 TOPB45_0842 147695cea4a9b770780c1aff3bad9d24 213 SUPERFAMILY SSF53335 30 182 1.92E-22 T 13-10-2018 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TOPB45_1370 60e38c312adf478faa5962f62999ad0b 290 SUPERFAMILY SSF54862 83 277 5.42E-17 T 13-10-2018 TOPB45_1370 60e38c312adf478faa5962f62999ad0b 290 Gene3D G3DSA:3.30.70.20 206 254 3.4E-7 T 13-10-2018 TOPB45_1370 60e38c312adf478faa5962f62999ad0b 290 Pfam PF00037 4Fe-4S binding domain 255 276 1.7E-4 T 13-10-2018 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain TOPB45_1370 60e38c312adf478faa5962f62999ad0b 290 Pfam PF12801 4Fe-4S binding domain 130 169 2.2 T 13-10-2018 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain TOPB45_1370 60e38c312adf478faa5962f62999ad0b 290 Pfam PF12801 4Fe-4S binding domain 50 60 18.0 T 13-10-2018 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain TOPB45_1370 60e38c312adf478faa5962f62999ad0b 290 Pfam PF12801 4Fe-4S binding domain 75 119 1.6E-10 T 13-10-2018 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain TOPB45_1370 60e38c312adf478faa5962f62999ad0b 290 Pfam PF12801 4Fe-4S binding domain 190 224 0.03 T 13-10-2018 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain TOPB45_1370 60e38c312adf478faa5962f62999ad0b 290 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 260 271 - T 13-10-2018 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site TOPB45_0339 1466fd565f9e2baf4d5df4ef636301e9 344 Pfam PF00535 Glycosyl transferase family 2 6 51 7.0E-9 T 13-10-2018 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 TOPB45_0339 1466fd565f9e2baf4d5df4ef636301e9 344 Pfam PF00535 Glycosyl transferase family 2 73 206 3.7E-9 T 13-10-2018 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 TOPB45_0339 1466fd565f9e2baf4d5df4ef636301e9 344 Gene3D G3DSA:3.90.550.10 1 252 1.3E-31 T 13-10-2018 IPR029044 Nucleotide-diphospho-sugar transferases TOPB45_0339 1466fd565f9e2baf4d5df4ef636301e9 344 SUPERFAMILY SSF53448 3 318 3.75E-37 T 13-10-2018 IPR029044 Nucleotide-diphospho-sugar transferases TOPB45_1170 343351c5d7fd8725732a4db9cc3745d6 241 ProSitePatterns PS00379 CDP-alcohol phosphatidyltransferases signature. 46 68 - T 13-10-2018 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 TOPB45_1170 343351c5d7fd8725732a4db9cc3745d6 241 Pfam PF01066 CDP-alcohol phosphatidyltransferase 5 68 1.6E-11 T 13-10-2018 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 TOPB45_1170 343351c5d7fd8725732a4db9cc3745d6 241 TIGRFAM TIGR00473 pssA: CDP-diacylglycerol-serine O-phosphatidyltransferase 10 172 3.9E-37 T 13-10-2018 IPR004533 CDP-diacylglycerol--serine O-phosphatidyltransferase KEGG: 00260+2.7.8.8|KEGG: 00564+2.7.8.8|MetaCyc: PWY-5669 TOPB45_1170 343351c5d7fd8725732a4db9cc3745d6 241 Gene3D G3DSA:1.20.120.1760 2 140 1.5E-10 T 13-10-2018 TOPB45_1438 f8d01392ad3c570339fae2c49d5b99b3 403 Hamap MF_00279 Pyridoxine 5'-phosphate synthase [pdxJ]. 162 403 101.537 T 13-10-2018 IPR004569 Pyridoxal phosphate (active vitamin B6) biosynthesis PdxJ GO:0005737|GO:0008615|GO:0033856 KEGG: 00750+2.6.99.2 TOPB45_1438 f8d01392ad3c570339fae2c49d5b99b3 403 Gene3D G3DSA:3.40.390.30 3 146 7.8E-32 T 13-10-2018 IPR023091 Metalloprotease catalytic domain superfamily, predicted GO:0004222 TOPB45_1438 f8d01392ad3c570339fae2c49d5b99b3 403 Hamap MF_00009 Endoribonuclease YbeY [ybeY]. 2 147 18.254 T 13-10-2018 IPR002036 Endoribonuclease YbeY GO:0004222|GO:0006364 TOPB45_1438 f8d01392ad3c570339fae2c49d5b99b3 403 SUPERFAMILY SSF63892 164 401 1.7E-88 T 13-10-2018 IPR036130 Pyridoxine 5'-phosphate synthase GO:0005737|GO:0008615|GO:0033856 KEGG: 00750+2.6.99.2 TOPB45_1438 f8d01392ad3c570339fae2c49d5b99b3 403 Pfam PF03740 Pyridoxal phosphate biosynthesis protein PdxJ 165 398 3.7E-93 T 13-10-2018 IPR004569 Pyridoxal phosphate (active vitamin B6) biosynthesis PdxJ GO:0005737|GO:0008615|GO:0033856 KEGG: 00750+2.6.99.2 TOPB45_1438 f8d01392ad3c570339fae2c49d5b99b3 403 TIGRFAM TIGR00559 pdxJ: pyridoxine 5'-phosphate synthase 165 399 4.4E-85 T 13-10-2018 IPR004569 Pyridoxal phosphate (active vitamin B6) biosynthesis PdxJ GO:0005737|GO:0008615|GO:0033856 KEGG: 00750+2.6.99.2 TOPB45_1438 f8d01392ad3c570339fae2c49d5b99b3 403 Pfam PF02130 Uncharacterized protein family UPF0054 17 124 6.9E-29 T 13-10-2018 IPR002036 Endoribonuclease YbeY GO:0004222|GO:0006364 TOPB45_1438 f8d01392ad3c570339fae2c49d5b99b3 403 SUPERFAMILY SSF55486 18 144 9.52E-30 T 13-10-2018 TOPB45_1438 f8d01392ad3c570339fae2c49d5b99b3 403 Gene3D G3DSA:3.20.20.70 152 403 7.1E-98 T 13-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 TOPB45_1438 f8d01392ad3c570339fae2c49d5b99b3 403 TIGRFAM TIGR00043 TIGR00043: rRNA maturation RNase YbeY 38 140 2.2E-24 T 13-10-2018 IPR002036 Endoribonuclease YbeY GO:0004222|GO:0006364 TOPB45_1559 bd509a5dafc45e93ca1278a6e7ad66a4 510 Gene3D G3DSA:1.25.40.10 274 500 1.3E-16 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_1559 bd509a5dafc45e93ca1278a6e7ad66a4 510 SMART SM00028 294 327 110.0 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_1559 bd509a5dafc45e93ca1278a6e7ad66a4 510 SMART SM00028 428 461 11.0 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_1559 bd509a5dafc45e93ca1278a6e7ad66a4 510 SMART SM00028 363 396 1.0E-4 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_1559 bd509a5dafc45e93ca1278a6e7ad66a4 510 SUPERFAMILY SSF48452 296 477 1.78E-12 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_0983 bf1db01022d5640bcc70536aafa1d451 135 SUPERFAMILY SSF52980 13 124 1.61E-22 T 13-10-2018 IPR011335 Restriction endonuclease type II-like Reactome: R-HSA-6783310 TOPB45_0983 bf1db01022d5640bcc70536aafa1d451 135 Gene3D G3DSA:3.40.1350.10 18 131 1.2E-27 T 13-10-2018 IPR011856 tRNA endonuclease-like domain superfamily GO:0003676|GO:0004518 TOPB45_0983 bf1db01022d5640bcc70536aafa1d451 135 Pfam PF02021 Uncharacterised protein family UPF0102 19 111 7.7E-23 T 13-10-2018 IPR003509 Uncharacterised protein family UPF0102 TOPB45_0983 bf1db01022d5640bcc70536aafa1d451 135 Hamap MF_00048 UPF0102 protein YraN [yraN]. 12 125 20.762 T 13-10-2018 IPR003509 Uncharacterised protein family UPF0102 TOPB45_0983 bf1db01022d5640bcc70536aafa1d451 135 TIGRFAM TIGR00252 TIGR00252: TIGR00252 family protein 12 124 5.3E-20 T 13-10-2018 IPR003509 Uncharacterised protein family UPF0102 TOPB45_0243 b3264045534ec81d7e667444d4c95e2d 158 Hamap MF_00107 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [ispF]. 3 158 29.895 T 13-10-2018 IPR003526 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase GO:0008685|GO:0016114 KEGG: 00900+4.6.1.12|MetaCyc: PWY-7560 TOPB45_0243 b3264045534ec81d7e667444d4c95e2d 158 Gene3D G3DSA:3.30.1330.50 1 158 1.3E-58 T 13-10-2018 IPR036571 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase superfamily GO:0008685|GO:0016114 KEGG: 00900+4.6.1.12|MetaCyc: PWY-7560 TOPB45_0243 b3264045534ec81d7e667444d4c95e2d 158 ProSitePatterns PS01350 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase signature. 37 52 - T 13-10-2018 IPR020555 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, conserved site GO:0008685 KEGG: 00900+4.6.1.12|MetaCyc: PWY-7560 TOPB45_0243 b3264045534ec81d7e667444d4c95e2d 158 Pfam PF02542 YgbB family 4 156 2.6E-54 T 13-10-2018 IPR003526 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase GO:0008685|GO:0016114 KEGG: 00900+4.6.1.12|MetaCyc: PWY-7560 TOPB45_0243 b3264045534ec81d7e667444d4c95e2d 158 TIGRFAM TIGR00151 ispF: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 5 158 2.9E-54 T 13-10-2018 IPR003526 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase GO:0008685|GO:0016114 KEGG: 00900+4.6.1.12|MetaCyc: PWY-7560 TOPB45_0243 b3264045534ec81d7e667444d4c95e2d 158 SUPERFAMILY SSF69765 1 157 8.63E-52 T 13-10-2018 IPR036571 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase superfamily GO:0008685|GO:0016114 KEGG: 00900+4.6.1.12|MetaCyc: PWY-7560 TOPB45_1271 c0510f8cd8613c0b6930b72ba0c75296 430 SMART SM00788 3 423 3.0E-280 T 13-10-2018 IPR001114 Adenylosuccinate synthetase GO:0004019|GO:0005525|GO:0006164 KEGG: 00230+6.3.4.4|KEGG: 00250+6.3.4.4|MetaCyc: PWY-7219|Reactome: R-HSA-73817 TOPB45_1271 c0510f8cd8613c0b6930b72ba0c75296 430 ProSitePatterns PS00513 Adenylosuccinate synthetase active site. 133 144 - T 13-10-2018 IPR033128 Adenylosuccinate synthase, active site KEGG: 00230+6.3.4.4|KEGG: 00250+6.3.4.4|MetaCyc: PWY-7219|Reactome: R-HSA-73817 TOPB45_1271 c0510f8cd8613c0b6930b72ba0c75296 430 Pfam PF00709 Adenylosuccinate synthetase 5 421 9.2E-187 T 13-10-2018 IPR001114 Adenylosuccinate synthetase GO:0004019|GO:0005525|GO:0006164 KEGG: 00230+6.3.4.4|KEGG: 00250+6.3.4.4|MetaCyc: PWY-7219|Reactome: R-HSA-73817 TOPB45_1271 c0510f8cd8613c0b6930b72ba0c75296 430 ProSitePatterns PS01266 Adenylosuccinate synthetase GTP-binding site. 10 17 - T 13-10-2018 IPR018220 Adenylosuccinate synthase, GTP-binding site GO:0005525 KEGG: 00230+6.3.4.4|KEGG: 00250+6.3.4.4|MetaCyc: PWY-7219|Reactome: R-HSA-73817 TOPB45_1271 c0510f8cd8613c0b6930b72ba0c75296 430 Gene3D G3DSA:3.40.440.10 5 258 1.3E-104 T 13-10-2018 TOPB45_1271 c0510f8cd8613c0b6930b72ba0c75296 430 Gene3D G3DSA:3.90.170.10 266 430 7.7E-71 T 13-10-2018 TOPB45_1271 c0510f8cd8613c0b6930b72ba0c75296 430 Hamap MF_00011 Adenylosuccinate synthetase [purA]. 1 430 205.411 T 13-10-2018 IPR001114 Adenylosuccinate synthetase GO:0004019|GO:0005525|GO:0006164 KEGG: 00230+6.3.4.4|KEGG: 00250+6.3.4.4|MetaCyc: PWY-7219|Reactome: R-HSA-73817 TOPB45_1271 c0510f8cd8613c0b6930b72ba0c75296 430 TIGRFAM TIGR00184 purA: adenylosuccinate synthase 5 428 5.1E-177 T 13-10-2018 IPR001114 Adenylosuccinate synthetase GO:0004019|GO:0005525|GO:0006164 KEGG: 00230+6.3.4.4|KEGG: 00250+6.3.4.4|MetaCyc: PWY-7219|Reactome: R-HSA-73817 TOPB45_1271 c0510f8cd8613c0b6930b72ba0c75296 430 Gene3D G3DSA:1.10.300.10 102 200 1.3E-104 T 13-10-2018 TOPB45_1271 c0510f8cd8613c0b6930b72ba0c75296 430 SUPERFAMILY SSF52540 1 423 2.23E-176 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0251 888bdd777ddb8f6314711c2347f1c407 117 Gene3D G3DSA:3.40.1230.10 1 117 2.7E-29 T 13-10-2018 IPR036748 MTH938-like superfamily TOPB45_0251 888bdd777ddb8f6314711c2347f1c407 117 SUPERFAMILY SSF64076 1 117 1.19E-21 T 13-10-2018 IPR036748 MTH938-like superfamily TOPB45_0251 888bdd777ddb8f6314711c2347f1c407 117 Pfam PF04430 Protein of unknown function (DUF498/DUF598) 2 114 2.4E-21 T 13-10-2018 IPR007523 NDUFAF3/Mth938 domain-containing protein TOPB45_0776 bc4e48214fcafd19af6365a4f14f549c 80 Hamap MF_00075 Translation initiation factor IF-1 [infA]. 1 73 27.209 T 13-10-2018 IPR004368 Translation initiation factor IF-1 GO:0003743|GO:0006413 TOPB45_0776 bc4e48214fcafd19af6365a4f14f549c 80 SUPERFAMILY SSF50249 1 75 9.55E-27 T 13-10-2018 IPR012340 Nucleic acid-binding, OB-fold TOPB45_0776 bc4e48214fcafd19af6365a4f14f549c 80 TIGRFAM TIGR00008 infA: translation initiation factor IF-1 3 70 4.5E-37 T 13-10-2018 IPR004368 Translation initiation factor IF-1 GO:0003743|GO:0006413 TOPB45_0776 bc4e48214fcafd19af6365a4f14f549c 80 Pfam PF01176 Translation initiation factor 1A / IF-1 10 70 1.1E-28 T 13-10-2018 IPR006196 RNA-binding domain, S1, IF1 type GO:0003723|GO:0003743|GO:0006413 TOPB45_0776 bc4e48214fcafd19af6365a4f14f549c 80 Gene3D G3DSA:2.40.50.140 2 70 3.4E-36 T 13-10-2018 TOPB45_0776 bc4e48214fcafd19af6365a4f14f549c 80 SMART SM00316 4 72 3.7E-4 T 13-10-2018 IPR022967 RNA-binding domain, S1 TOPB45_1578 7b3cb43988d9f086ffc05e0248dc03bc 583 SUPERFAMILY SSF55785 115 222 5.41E-9 T 13-10-2018 IPR035965 PAS domain superfamily TOPB45_1578 7b3cb43988d9f086ffc05e0248dc03bc 583 Gene3D G3DSA:3.30.565.10 304 462 9.3E-36 T 13-10-2018 IPR036890 Histidine kinase/HSP90-like ATPase superfamily TOPB45_1578 7b3cb43988d9f086ffc05e0248dc03bc 583 Gene3D G3DSA:1.10.287.130 225 302 8.6E-6 T 13-10-2018 TOPB45_1578 7b3cb43988d9f086ffc05e0248dc03bc 583 SUPERFAMILY SSF52172 472 583 9.82E-23 T 13-10-2018 IPR011006 CheY-like superfamily TOPB45_1578 7b3cb43988d9f086ffc05e0248dc03bc 583 PRINTS PR00344 Bacterial sensor protein C-terminal signature 417 435 1.7E-16 T 13-10-2018 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TOPB45_1578 7b3cb43988d9f086ffc05e0248dc03bc 583 PRINTS PR00344 Bacterial sensor protein C-terminal signature 441 454 1.7E-16 T 13-10-2018 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TOPB45_1578 7b3cb43988d9f086ffc05e0248dc03bc 583 PRINTS PR00344 Bacterial sensor protein C-terminal signature 406 416 1.7E-16 T 13-10-2018 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TOPB45_1578 7b3cb43988d9f086ffc05e0248dc03bc 583 PRINTS PR00344 Bacterial sensor protein C-terminal signature 388 402 1.7E-16 T 13-10-2018 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TOPB45_1578 7b3cb43988d9f086ffc05e0248dc03bc 583 SUPERFAMILY SSF55874 297 459 1.7E-34 T 13-10-2018 IPR036890 Histidine kinase/HSP90-like ATPase superfamily TOPB45_1578 7b3cb43988d9f086ffc05e0248dc03bc 583 SMART SM00387 347 457 3.7E-28 T 13-10-2018 IPR003594 Histidine kinase/HSP90-like ATPase TOPB45_1578 7b3cb43988d9f086ffc05e0248dc03bc 583 Gene3D G3DSA:3.40.50.2300 463 583 2.9E-21 T 13-10-2018 TOPB45_1578 7b3cb43988d9f086ffc05e0248dc03bc 583 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 112 230 1.5E-10 T 13-10-2018 IPR000014 PAS domain TOPB45_1578 7b3cb43988d9f086ffc05e0248dc03bc 583 SMART SM00091 3 70 5.3 T 13-10-2018 IPR000014 PAS domain TOPB45_1578 7b3cb43988d9f086ffc05e0248dc03bc 583 SMART SM00091 110 175 0.055 T 13-10-2018 IPR000014 PAS domain TOPB45_1578 7b3cb43988d9f086ffc05e0248dc03bc 583 Pfam PF00072 Response regulator receiver domain 473 578 6.7E-17 T 13-10-2018 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TOPB45_1578 7b3cb43988d9f086ffc05e0248dc03bc 583 Gene3D G3DSA:3.30.450.20 2 50 4.0E-5 T 13-10-2018 TOPB45_1578 7b3cb43988d9f086ffc05e0248dc03bc 583 SMART SM00448 471 578 9.8E-17 T 13-10-2018 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TOPB45_1578 7b3cb43988d9f086ffc05e0248dc03bc 583 Gene3D G3DSA:3.30.450.20 111 223 3.4E-11 T 13-10-2018 TOPB45_1578 7b3cb43988d9f086ffc05e0248dc03bc 583 Pfam PF13426 PAS domain 124 222 2.0E-6 T 13-10-2018 IPR000014 PAS domain TOPB45_1578 7b3cb43988d9f086ffc05e0248dc03bc 583 Pfam PF13426 PAS domain 14 38 0.49 T 13-10-2018 IPR000014 PAS domain TOPB45_1578 7b3cb43988d9f086ffc05e0248dc03bc 583 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 347 455 4.5E-19 T 13-10-2018 IPR003594 Histidine kinase/HSP90-like ATPase TOPB45_0268 c8cdfd5027405a13215daef1a627e009 174 Gene3D G3DSA:3.40.50.300 1 173 1.1E-63 T 13-10-2018 TOPB45_0268 c8cdfd5027405a13215daef1a627e009 174 SUPERFAMILY SSF52540 5 173 6.1E-48 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0268 c8cdfd5027405a13215daef1a627e009 174 PIRSF PIRSF015617 1 174 2.4E-61 T 13-10-2018 IPR003724 ATP:cob(I)alamin adenosyltransferase CobA/CobO/ButR GO:0005524|GO:0008817|GO:0009236 KEGG: 00860+2.5.1.17 TOPB45_0268 c8cdfd5027405a13215daef1a627e009 174 TIGRFAM TIGR00708 cobA: cob(I)yrinic acid a,c-diamide adenosyltransferase 2 173 2.7E-50 T 13-10-2018 IPR003724 ATP:cob(I)alamin adenosyltransferase CobA/CobO/ButR GO:0005524|GO:0008817|GO:0009236 KEGG: 00860+2.5.1.17 TOPB45_0268 c8cdfd5027405a13215daef1a627e009 174 Pfam PF02572 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP 5 173 5.3E-63 T 13-10-2018 IPR003724 ATP:cob(I)alamin adenosyltransferase CobA/CobO/ButR GO:0005524|GO:0008817|GO:0009236 KEGG: 00860+2.5.1.17 TOPB45_0388 846cc5400cc65fee86000f57466e3e74 278 SUPERFAMILY SSF53790 5 220 4.06E-67 T 13-10-2018 IPR035996 Tetrapyrrole methylase superfamily GO:0008168 Reactome: R-HSA-5358493 TOPB45_0388 846cc5400cc65fee86000f57466e3e74 278 PIRSF PIRSF005917 1 278 4.0E-86 T 13-10-2018 IPR008189 rRNA small subunit methyltransferase I GO:0008168 TOPB45_0388 846cc5400cc65fee86000f57466e3e74 278 Gene3D G3DSA:3.40.1010.10 1 115 1.0E-41 T 13-10-2018 IPR014777 Tetrapyrrole methylase, subdomain 1 GO:0008168 Reactome: R-HSA-5358493 TOPB45_0388 846cc5400cc65fee86000f57466e3e74 278 TIGRFAM TIGR00096 TIGR00096: 16S rRNA (cytidine(1402)-2'-O)-methyltransferase 8 275 1.4E-67 T 13-10-2018 IPR008189 rRNA small subunit methyltransferase I GO:0008168 TOPB45_0388 846cc5400cc65fee86000f57466e3e74 278 Pfam PF00590 Tetrapyrrole (Corrin/Porphyrin) Methylases 7 208 3.1E-31 T 13-10-2018 IPR000878 Tetrapyrrole methylase GO:0008168 Reactome: R-HSA-5358493 TOPB45_0388 846cc5400cc65fee86000f57466e3e74 278 Hamap MF_01877 Ribosomal RNA small subunit methyltransferase I [rsmI]. 7 223 31.971 T 13-10-2018 IPR008189 rRNA small subunit methyltransferase I GO:0008168 TOPB45_0388 846cc5400cc65fee86000f57466e3e74 278 Gene3D G3DSA:3.30.950.10 116 227 1.4E-27 T 13-10-2018 IPR014776 Tetrapyrrole methylase, subdomain 2 GO:0008168 Reactome: R-HSA-5358493 TOPB45_1200 63b2f2403d066b4ae53bb5a65e7d5502 353 Pfam PF02665 Nitrate reductase gamma subunit 124 284 1.2E-20 T 13-10-2018 IPR023234 NarG-like domain TOPB45_1200 63b2f2403d066b4ae53bb5a65e7d5502 353 SUPERFAMILY SSF103501 26 303 3.14E-50 T 13-10-2018 IPR036197 NarG-like superfamily TOPB45_1200 63b2f2403d066b4ae53bb5a65e7d5502 353 Gene3D G3DSA:1.20.950.20 115 288 9.1E-21 T 13-10-2018 TOPB45_0986 79d38b08b27f2793cd2310d75f9e2b69 431 SUPERFAMILY SSF55021 352 422 9.7E-13 T 13-10-2018 TOPB45_0986 79d38b08b27f2793cd2310d75f9e2b69 431 Gene3D G3DSA:3.30.360.10 136 346 1.3E-164 T 13-10-2018 TOPB45_0986 79d38b08b27f2793cd2310d75f9e2b69 431 SUPERFAMILY SSF55347 137 302 1.44E-52 T 13-10-2018 TOPB45_0986 79d38b08b27f2793cd2310d75f9e2b69 431 Pfam PF00742 Homoserine dehydrogenase 137 315 2.6E-62 T 13-10-2018 IPR001342 Homoserine dehydrogenase, catalytic GO:0006520|GO:0055114 KEGG: 00260+1.1.1.3|KEGG: 00270+1.1.1.3|KEGG: 00300+1.1.1.3 TOPB45_0986 79d38b08b27f2793cd2310d75f9e2b69 431 Gene3D G3DSA:3.30.70.260 347 421 1.3E-164 T 13-10-2018 TOPB45_0986 79d38b08b27f2793cd2310d75f9e2b69 431 PIRSF PIRSF000098 1 431 4.6E-163 T 13-10-2018 IPR016204 Homoserine dehydrogenase GO:0004412|GO:0006520|GO:0055114 KEGG: 00260+1.1.1.3|KEGG: 00270+1.1.1.3|KEGG: 00300+1.1.1.3 TOPB45_0986 79d38b08b27f2793cd2310d75f9e2b69 431 Pfam PF03447 Homoserine dehydrogenase, NAD binding domain 10 124 4.9E-16 T 13-10-2018 IPR005106 Aspartate/homoserine dehydrogenase, NAD-binding GO:0016491|GO:0050661|GO:0055114 TOPB45_0986 79d38b08b27f2793cd2310d75f9e2b69 431 ProSitePatterns PS01042 Homoserine dehydrogenase signature. 183 205 - T 13-10-2018 IPR019811 Homoserine dehydrogenase, conserved site GO:0006520|GO:0055114 KEGG: 00260+1.1.1.3|KEGG: 00270+1.1.1.3|KEGG: 00300+1.1.1.3 TOPB45_0986 79d38b08b27f2793cd2310d75f9e2b69 431 SUPERFAMILY SSF51735 1 158 1.77E-35 T 13-10-2018 IPR036291 NAD(P)-binding domain superfamily TOPB45_0986 79d38b08b27f2793cd2310d75f9e2b69 431 Gene3D G3DSA:3.40.50.720 4 340 1.3E-164 T 13-10-2018 TOPB45_0986 79d38b08b27f2793cd2310d75f9e2b69 431 Pfam PF01842 ACT domain 352 419 3.4E-12 T 13-10-2018 IPR002912 ACT domain TOPB45_0943 d4693ad9fd37ae907f0d6fa95588cff9 361 SUPERFAMILY SSF53756 3 357 2.47E-92 T 13-10-2018 TOPB45_0943 d4693ad9fd37ae907f0d6fa95588cff9 361 Pfam PF04101 Glycosyltransferase family 28 C-terminal domain 179 344 9.4E-38 T 13-10-2018 IPR007235 Glycosyl transferase, family 28, C-terminal GO:0016758 KEGG: 00550+2.4.1.227|MetaCyc: PWY-5265|MetaCyc: PWY-6385|MetaCyc: PWY-6470|MetaCyc: PWY-6471|Reactome: R-HSA-446193|Reactome: R-HSA-5633231 TOPB45_0943 d4693ad9fd37ae907f0d6fa95588cff9 361 Hamap MF_00033 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [murG]. 3 357 31.285 T 13-10-2018 IPR006009 N-acetylglucosaminyltransferase, MurG GO:0050511 KEGG: 00550+2.4.1.227|MetaCyc: PWY-5265|MetaCyc: PWY-6385|MetaCyc: PWY-6470|MetaCyc: PWY-6471 TOPB45_0943 d4693ad9fd37ae907f0d6fa95588cff9 361 Pfam PF03033 Glycosyltransferase family 28 N-terminal domain 4 140 1.0E-28 T 13-10-2018 IPR004276 Glycosyltransferase family 28, N-terminal domain GO:0005975|GO:0016758|GO:0030259 KEGG: 00550+2.4.1.227|MetaCyc: PWY-5265|MetaCyc: PWY-6385|MetaCyc: PWY-6470|MetaCyc: PWY-6471 TOPB45_0943 d4693ad9fd37ae907f0d6fa95588cff9 361 Gene3D G3DSA:3.40.50.2000 173 340 1.5E-48 T 13-10-2018 TOPB45_0943 d4693ad9fd37ae907f0d6fa95588cff9 361 Gene3D G3DSA:3.40.50.2000 2 172 2.1E-50 T 13-10-2018 TOPB45_0943 d4693ad9fd37ae907f0d6fa95588cff9 361 TIGRFAM TIGR01133 murG: undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase 4 351 2.8E-85 T 13-10-2018 IPR006009 N-acetylglucosaminyltransferase, MurG GO:0050511 KEGG: 00550+2.4.1.227|MetaCyc: PWY-5265|MetaCyc: PWY-6385|MetaCyc: PWY-6470|MetaCyc: PWY-6471 TOPB45_0253 80be70a67dc221e0b894fea6e946e637 74 SUPERFAMILY SSF143800 1 67 1.29E-25 T 13-10-2018 IPR034704 L28p-like Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0253 80be70a67dc221e0b894fea6e946e637 74 Hamap MF_00501 50S ribosomal protein L31 [rpmE]. 1 68 29.617 T 13-10-2018 IPR027491 Ribosomal protein L31 type A GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0253 80be70a67dc221e0b894fea6e946e637 74 Gene3D G3DSA:2.30.170.50 1 69 2.5E-31 T 13-10-2018 TOPB45_0253 80be70a67dc221e0b894fea6e946e637 74 ProSitePatterns PS01143 Ribosomal protein L31 signature. 35 56 - T 13-10-2018 IPR002150 Ribosomal protein L31 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0253 80be70a67dc221e0b894fea6e946e637 74 TIGRFAM TIGR00105 L31: ribosomal protein bL31 1 66 1.6E-29 T 13-10-2018 IPR002150 Ribosomal protein L31 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0253 80be70a67dc221e0b894fea6e946e637 74 PRINTS PR01249 Ribosomal protein L31 signature 2 19 5.3E-20 T 13-10-2018 IPR002150 Ribosomal protein L31 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0253 80be70a67dc221e0b894fea6e946e637 74 PRINTS PR01249 Ribosomal protein L31 signature 31 46 5.3E-20 T 13-10-2018 IPR002150 Ribosomal protein L31 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0253 80be70a67dc221e0b894fea6e946e637 74 PRINTS PR01249 Ribosomal protein L31 signature 46 64 5.3E-20 T 13-10-2018 IPR002150 Ribosomal protein L31 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0253 80be70a67dc221e0b894fea6e946e637 74 Pfam PF01197 Ribosomal protein L31 1 65 3.4E-31 T 13-10-2018 IPR002150 Ribosomal protein L31 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_1548 f22b68200ee84453feb4348a451b7de3 514 PIRSF PIRSF039088 2 505 1.7E-250 T 13-10-2018 IPR005294 ATP synthase, F1 complex, alpha subunit GO:0015986|GO:0045261|GO:0046933 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7980|Reactome: R-HSA-1268020|Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_1548 f22b68200ee84453feb4348a451b7de3 514 Gene3D G3DSA:1.20.150.20 374 508 3.0E-52 T 13-10-2018 IPR038376 ATP synthase, alpha subunit, C-terminal domain superfamily KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7980|Reactome: R-HSA-1268020|Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_1548 f22b68200ee84453feb4348a451b7de3 514 Gene3D G3DSA:3.40.50.300 96 373 1.2E-124 T 13-10-2018 TOPB45_1548 f22b68200ee84453feb4348a451b7de3 514 SUPERFAMILY SSF52540 98 372 6.77E-99 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1548 f22b68200ee84453feb4348a451b7de3 514 SUPERFAMILY SSF47917 374 502 8.89E-47 T 13-10-2018 TOPB45_1548 f22b68200ee84453feb4348a451b7de3 514 Gene3D G3DSA:2.40.30.20 3 95 1.4E-29 T 13-10-2018 IPR023366 ATP synthase subunit alpha, N-terminal domain-like superfamily KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7980 TOPB45_1548 f22b68200ee84453feb4348a451b7de3 514 Hamap MF_01346 ATP synthase subunit alpha [atpA]. 2 503 49.207 T 13-10-2018 IPR005294 ATP synthase, F1 complex, alpha subunit GO:0015986|GO:0045261|GO:0046933 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7980|Reactome: R-HSA-1268020|Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_1548 f22b68200ee84453feb4348a451b7de3 514 ProSitePatterns PS00152 ATP synthase alpha and beta subunits signature. 357 366 - T 13-10-2018 IPR020003 ATPase, alpha/beta subunit, nucleotide-binding domain, active site GO:0005524 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7980 TOPB45_1548 f22b68200ee84453feb4348a451b7de3 514 SUPERFAMILY SSF50615 11 96 1.78E-23 T 13-10-2018 IPR036121 ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily GO:0046034|GO:1902600 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7980 TOPB45_1548 f22b68200ee84453feb4348a451b7de3 514 Pfam PF00306 ATP synthase alpha/beta chain, C terminal domain 373 498 8.2E-51 T 13-10-2018 IPR000793 ATP synthase, alpha subunit, C-terminal GO:0015986 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7980|Reactome: R-HSA-1268020|Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_1548 f22b68200ee84453feb4348a451b7de3 514 Pfam PF00006 ATP synthase alpha/beta family, nucleotide-binding domain 151 366 3.2E-73 T 13-10-2018 IPR000194 ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain GO:0005524 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7980 TOPB45_1548 f22b68200ee84453feb4348a451b7de3 514 TIGRFAM TIGR00962 atpA: ATP synthase F1, alpha subunit 4 502 3.8E-245 T 13-10-2018 IPR005294 ATP synthase, F1 complex, alpha subunit GO:0015986|GO:0045261|GO:0046933 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7980|Reactome: R-HSA-1268020|Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_1548 f22b68200ee84453feb4348a451b7de3 514 Pfam PF02874 ATP synthase alpha/beta family, beta-barrel domain 28 94 3.2E-9 T 13-10-2018 IPR004100 ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain GO:0046034|GO:1902600 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7980 TOPB45_1010 fd1b2a2ffd71b89a57885e15893e110e 312 Gene3D G3DSA:3.90.650.10 143 310 1.6E-46 T 13-10-2018 IPR036676 PurM-like, C-terminal domain superfamily TOPB45_1010 fd1b2a2ffd71b89a57885e15893e110e 312 Gene3D G3DSA:3.30.1330.10 1 141 6.9E-35 T 13-10-2018 IPR036921 PurM-like, N-terminal domain superfamily TOPB45_1010 fd1b2a2ffd71b89a57885e15893e110e 312 Hamap MF_02128 Thiamine-monophosphate kinase [thiL]. 1 310 25.796 T 13-10-2018 IPR006283 Thiamine-monophosphate kinase GO:0009030|GO:0009228 KEGG: 00730+2.7.4.16|MetaCyc: PWY-6893|MetaCyc: PWY-6894|MetaCyc: PWY-6896|MetaCyc: PWY-6897 TOPB45_1010 fd1b2a2ffd71b89a57885e15893e110e 312 TIGRFAM TIGR01379 thiL: thiamine-phosphate kinase 5 310 1.1E-79 T 13-10-2018 IPR006283 Thiamine-monophosphate kinase GO:0009030|GO:0009228 KEGG: 00730+2.7.4.16|MetaCyc: PWY-6893|MetaCyc: PWY-6894|MetaCyc: PWY-6896|MetaCyc: PWY-6897 TOPB45_1010 fd1b2a2ffd71b89a57885e15893e110e 312 PIRSF PIRSF005303 1 310 2.7E-86 T 13-10-2018 IPR006283 Thiamine-monophosphate kinase GO:0009030|GO:0009228 KEGG: 00730+2.7.4.16|MetaCyc: PWY-6893|MetaCyc: PWY-6894|MetaCyc: PWY-6896|MetaCyc: PWY-6897 TOPB45_1010 fd1b2a2ffd71b89a57885e15893e110e 312 Pfam PF02769 AIR synthase related protein, C-terminal domain 149 294 1.8E-11 T 13-10-2018 IPR010918 PurM-like, C-terminal domain TOPB45_1010 fd1b2a2ffd71b89a57885e15893e110e 312 SUPERFAMILY SSF56042 141 296 5.23E-29 T 13-10-2018 IPR036676 PurM-like, C-terminal domain superfamily TOPB45_1010 fd1b2a2ffd71b89a57885e15893e110e 312 SUPERFAMILY SSF55326 6 137 1.74E-30 T 13-10-2018 IPR036921 PurM-like, N-terminal domain superfamily TOPB45_1010 fd1b2a2ffd71b89a57885e15893e110e 312 Pfam PF00586 AIR synthase related protein, N-terminal domain 26 137 1.0E-17 T 13-10-2018 IPR016188 PurM-like, N-terminal domain TOPB45_0692 80d5cb0479fc0db085b2c2eede2ccb0c 175 SUPERFAMILY SSF46785 7 80 4.35E-16 T 13-10-2018 IPR036390 Winged helix DNA-binding domain superfamily TOPB45_0692 80d5cb0479fc0db085b2c2eede2ccb0c 175 TIGRFAM TIGR00281 TIGR00281: segregation and condensation protein B 7 169 9.7E-39 T 13-10-2018 IPR005234 Chromosome segregation/condensation protein ScpB GO:0051304 TOPB45_0692 80d5cb0479fc0db085b2c2eede2ccb0c 175 Pfam PF04079 Segregation and condensation complex subunit ScpB 10 167 2.3E-50 T 13-10-2018 IPR005234 Chromosome segregation/condensation protein ScpB GO:0051304 TOPB45_0692 80d5cb0479fc0db085b2c2eede2ccb0c 175 SUPERFAMILY SSF46785 83 158 1.4E-20 T 13-10-2018 IPR036390 Winged helix DNA-binding domain superfamily TOPB45_0692 80d5cb0479fc0db085b2c2eede2ccb0c 175 PIRSF PIRSF019345 2 175 7.0E-53 T 13-10-2018 IPR005234 Chromosome segregation/condensation protein ScpB GO:0051304 TOPB45_0692 80d5cb0479fc0db085b2c2eede2ccb0c 175 Gene3D G3DSA:1.10.10.10 82 175 4.6E-32 T 13-10-2018 IPR036388 Winged helix-like DNA-binding domain superfamily TOPB45_0692 80d5cb0479fc0db085b2c2eede2ccb0c 175 Gene3D G3DSA:1.10.10.10 1 81 2.6E-22 T 13-10-2018 IPR036388 Winged helix-like DNA-binding domain superfamily TOPB45_0283 bd9264911cb76e52b53a735bb0d7cdc6 368 SUPERFAMILY SSF52540 1 306 2.78E-75 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0283 bd9264911cb76e52b53a735bb0d7cdc6 368 Pfam PF01926 50S ribosome-binding GTPase 2 116 5.3E-24 T 13-10-2018 IPR006073 GTP binding domain GO:0005525 TOPB45_0283 bd9264911cb76e52b53a735bb0d7cdc6 368 Pfam PF06071 Protein of unknown function (DUF933) 284 367 7.4E-37 T 13-10-2018 IPR013029 YchF, C-terminal domain Reactome: R-HSA-114608 TOPB45_0283 bd9264911cb76e52b53a735bb0d7cdc6 368 SUPERFAMILY SSF81271 284 365 3.92E-33 T 13-10-2018 IPR012676 TGS-like KEGG: 00970+6.1.1.3 TOPB45_0283 bd9264911cb76e52b53a735bb0d7cdc6 368 Gene3D G3DSA:3.10.20.30 47 366 7.2E-142 T 13-10-2018 IPR012675 Beta-grasp domain superfamily TOPB45_0283 bd9264911cb76e52b53a735bb0d7cdc6 368 PIRSF PIRSF006641 1 368 9.3E-150 T 13-10-2018 IPR004396 Ribosome-binding ATPase YchF/Obg-like ATPase 1 GO:0005525 Reactome: R-HSA-114608 TOPB45_0283 bd9264911cb76e52b53a735bb0d7cdc6 368 Hamap MF_00944 Ribosome-binding ATPase YchF [ychF]. 1 368 41.89 T 13-10-2018 IPR004396 Ribosome-binding ATPase YchF/Obg-like ATPase 1 GO:0005525 Reactome: R-HSA-114608 TOPB45_0283 bd9264911cb76e52b53a735bb0d7cdc6 368 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 69 84 5.2E-36 T 13-10-2018 IPR006073 GTP binding domain GO:0005525 TOPB45_0283 bd9264911cb76e52b53a735bb0d7cdc6 368 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 86 104 5.2E-36 T 13-10-2018 IPR006073 GTP binding domain GO:0005525 TOPB45_0283 bd9264911cb76e52b53a735bb0d7cdc6 368 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 3 23 5.2E-36 T 13-10-2018 IPR006073 GTP binding domain GO:0005525 TOPB45_0283 bd9264911cb76e52b53a735bb0d7cdc6 368 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 25 43 5.2E-36 T 13-10-2018 IPR006073 GTP binding domain GO:0005525 TOPB45_0283 bd9264911cb76e52b53a735bb0d7cdc6 368 Gene3D G3DSA:3.40.50.300 1 283 7.2E-142 T 13-10-2018 TOPB45_0283 bd9264911cb76e52b53a735bb0d7cdc6 368 TIGRFAM TIGR00092 TIGR00092: GTP-binding protein YchF 2 368 1.0E-137 T 13-10-2018 IPR004396 Ribosome-binding ATPase YchF/Obg-like ATPase 1 GO:0005525 Reactome: R-HSA-114608 TOPB45_0283 bd9264911cb76e52b53a735bb0d7cdc6 368 Gene3D G3DSA:1.10.150.300 112 202 7.2E-142 T 13-10-2018 IPR023192 TGS-like domain superfamily Reactome: R-HSA-114608 TOPB45_0145 f868a03cabaefc63e13c4a0ad503e89a 509 Gene3D G3DSA:1.20.1260.30 3 148 1.3E-36 T 13-10-2018 IPR038333 N6 adenine-specific DNA methyltransferase, N-terminal domain superfamily TOPB45_0145 f868a03cabaefc63e13c4a0ad503e89a 509 Pfam PF02384 N-6 DNA Methylase 156 469 5.0E-109 T 13-10-2018 IPR003356 DNA methylase, adenine-specific GO:0003677|GO:0006306|GO:0008170 TOPB45_0145 f868a03cabaefc63e13c4a0ad503e89a 509 PRINTS PR00507 N12 class N6 adenine-specific DNA methyltransferase signature 203 217 1.6E-22 T 13-10-2018 TOPB45_0145 f868a03cabaefc63e13c4a0ad503e89a 509 PRINTS PR00507 N12 class N6 adenine-specific DNA methyltransferase signature 310 334 1.6E-22 T 13-10-2018 TOPB45_0145 f868a03cabaefc63e13c4a0ad503e89a 509 PRINTS PR00507 N12 class N6 adenine-specific DNA methyltransferase signature 180 196 1.6E-22 T 13-10-2018 TOPB45_0145 f868a03cabaefc63e13c4a0ad503e89a 509 PRINTS PR00507 N12 class N6 adenine-specific DNA methyltransferase signature 275 287 1.6E-22 T 13-10-2018 TOPB45_0145 f868a03cabaefc63e13c4a0ad503e89a 509 SUPERFAMILY SSF53335 9 508 1.98E-134 T 13-10-2018 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TOPB45_0145 f868a03cabaefc63e13c4a0ad503e89a 509 Pfam PF12161 HsdM N-terminal domain 9 126 1.1E-22 T 13-10-2018 IPR022749 N6 adenine-specific DNA methyltransferase, N-terminal domain TOPB45_0145 f868a03cabaefc63e13c4a0ad503e89a 509 Gene3D G3DSA:3.40.50.150 157 453 7.0E-100 T 13-10-2018 TOPB45_0145 f868a03cabaefc63e13c4a0ad503e89a 509 ProSitePatterns PS00092 N-6 Adenine-specific DNA methylases signature. 278 284 - T 13-10-2018 IPR002052 DNA methylase, N-6 adenine-specific, conserved site GO:0003676|GO:0008168|GO:0032259 TOPB45_1282 074d95da8735b7992bd44427c690473b 351 Gene3D G3DSA:3.30.1330.10 3 169 1.4E-63 T 13-10-2018 IPR036921 PurM-like, N-terminal domain superfamily TOPB45_1282 074d95da8735b7992bd44427c690473b 351 Pfam PF00586 AIR synthase related protein, N-terminal domain 60 163 1.1E-15 T 13-10-2018 IPR016188 PurM-like, N-terminal domain TOPB45_1282 074d95da8735b7992bd44427c690473b 351 TIGRFAM TIGR00878 purM: phosphoribosylformylglycinamidine cyclo-ligase 6 337 1.9E-130 T 13-10-2018 IPR004733 Phosphoribosylformylglycinamidine cyclo-ligase GO:0004641|GO:0005737|GO:0006189 KEGG: 00230+6.3.3.1|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|Reactome: R-HSA-73817 TOPB45_1282 074d95da8735b7992bd44427c690473b 351 SUPERFAMILY SSF56042 170 343 1.92E-54 T 13-10-2018 IPR036676 PurM-like, C-terminal domain superfamily TOPB45_1282 074d95da8735b7992bd44427c690473b 351 Pfam PF02769 AIR synthase related protein, C-terminal domain 176 342 2.9E-27 T 13-10-2018 IPR010918 PurM-like, C-terminal domain TOPB45_1282 074d95da8735b7992bd44427c690473b 351 SUPERFAMILY SSF55326 6 169 5.08E-45 T 13-10-2018 IPR036921 PurM-like, N-terminal domain superfamily TOPB45_1282 074d95da8735b7992bd44427c690473b 351 Hamap MF_00741 Phosphoribosylformylglycinamidine cyclo-ligase [purM]. 5 348 43.796 T 13-10-2018 IPR004733 Phosphoribosylformylglycinamidine cyclo-ligase GO:0004641|GO:0005737|GO:0006189 KEGG: 00230+6.3.3.1|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|Reactome: R-HSA-73817 TOPB45_1282 074d95da8735b7992bd44427c690473b 351 Gene3D G3DSA:3.90.650.10 170 345 4.6E-65 T 13-10-2018 IPR036676 PurM-like, C-terminal domain superfamily TOPB45_0495 ca0e2921b3c0975f552b386272ced5a4 108 SUPERFAMILY SSF54913 3 106 7.04E-35 T 13-10-2018 IPR011322 Nitrogen regulatory PII-like, alpha/beta TOPB45_0495 ca0e2921b3c0975f552b386272ced5a4 108 Pfam PF03091 CutA1 divalent ion tolerance protein 7 103 7.6E-35 T 13-10-2018 IPR004323 Divalent ion tolerance protein, CutA GO:0010038 TOPB45_0495 ca0e2921b3c0975f552b386272ced5a4 108 Gene3D G3DSA:3.30.70.120 1 108 1.3E-39 T 13-10-2018 IPR015867 Nitrogen regulatory protein PII/ATP phosphoribosyltransferase, C-terminal TOPB45_0843 683a54184608039c1fa5456cc900a83e 286 ProSitePatterns PS00092 N-6 Adenine-specific DNA methylases signature. 181 187 - T 13-10-2018 IPR002052 DNA methylase, N-6 adenine-specific, conserved site GO:0003676|GO:0008168|GO:0032259 TOPB45_0843 683a54184608039c1fa5456cc900a83e 286 TIGRFAM TIGR00536 hemK_fam: methyltransferase, HemK family 5 278 5.0E-65 T 13-10-2018 IPR004556 Modification methylase HemK GO:0006479|GO:0008276 TOPB45_0843 683a54184608039c1fa5456cc900a83e 286 TIGRFAM TIGR03534 RF_mod_PrmC: protein-(glutamine-N5) methyltransferase, release factor-specific 27 272 9.2E-71 T 13-10-2018 IPR019874 Protein-(glutamine-N5) methyltransferase, release factor-specific GO:0008168 TOPB45_0843 683a54184608039c1fa5456cc900a83e 286 Pfam PF05175 Methyltransferase small domain 95 188 7.8E-13 T 13-10-2018 IPR007848 Methyltransferase small domain GO:0008168 TOPB45_0843 683a54184608039c1fa5456cc900a83e 286 Hamap MF_02126 Release factor glutamine methyltransferase [prmC]. 4 276 36.308 T 13-10-2018 IPR019874 Protein-(glutamine-N5) methyltransferase, release factor-specific GO:0008168 TOPB45_0843 683a54184608039c1fa5456cc900a83e 286 Gene3D G3DSA:1.10.8.10 1 83 5.2E-11 T 13-10-2018 TOPB45_0843 683a54184608039c1fa5456cc900a83e 286 SUPERFAMILY SSF53335 11 274 1.84E-45 T 13-10-2018 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TOPB45_0843 683a54184608039c1fa5456cc900a83e 286 Gene3D G3DSA:3.40.50.150 84 284 6.0E-55 T 13-10-2018 TOPB45_1561 81720ea93b65f5b0158ef6bcd8163d58 400 Pfam PF00155 Aminotransferase class I and II 35 391 1.6E-57 T 13-10-2018 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 TOPB45_1561 81720ea93b65f5b0158ef6bcd8163d58 400 PIRSF PIRSF000517 4 400 9.1E-99 T 13-10-2018 IPR005958 Tyrosine/nicotianamine aminotransferase GO:0006520|GO:0008483|GO:0030170 Reactome: R-HSA-71182 TOPB45_1561 81720ea93b65f5b0158ef6bcd8163d58 400 Gene3D G3DSA:3.90.1150.10 23 394 7.5E-124 T 13-10-2018 IPR015422 Pyridoxal phosphate-dependent transferase domain 1 GO:0003824 TOPB45_1561 81720ea93b65f5b0158ef6bcd8163d58 400 SUPERFAMILY SSF53383 14 397 8.51E-97 T 13-10-2018 IPR015424 Pyridoxal phosphate-dependent transferase TOPB45_1561 81720ea93b65f5b0158ef6bcd8163d58 400 TIGRFAM TIGR01265 tyr_nico_aTase: tyrosine/nicotianamine family aminotransferase 12 397 5.1E-98 T 13-10-2018 IPR005958 Tyrosine/nicotianamine aminotransferase GO:0006520|GO:0008483|GO:0030170 Reactome: R-HSA-71182 TOPB45_1561 81720ea93b65f5b0158ef6bcd8163d58 400 Gene3D G3DSA:3.40.640.10 54 294 7.5E-124 T 13-10-2018 IPR015421 Pyridoxal phosphate-dependent transferase, major domain GO:0003824 TOPB45_1632 f52f065f6ad0813366f16bc4b89c8357 302 Hamap MF_01109 Ornithine carbamoyltransferase, catabolic [argI]. 3 301 75.193 T 13-10-2018 IPR024904 Ornithine carbamoyltransferase GO:0004585|GO:0006591 KEGG: 00220+2.1.3.3|MetaCyc: PWY-4981|MetaCyc: PWY-4984|MetaCyc: PWY-7400 TOPB45_1632 f52f065f6ad0813366f16bc4b89c8357 302 Gene3D G3DSA:3.40.50.1370 131 295 6.4E-111 T 13-10-2018 IPR036901 Aspartate/ornithine carbamoyltransferase superfamily GO:0006520|GO:0016597|GO:0016743 TOPB45_1632 f52f065f6ad0813366f16bc4b89c8357 302 PRINTS PR00100 Aspartate/ornithine carbamoyltransferase superfamily signature 46 65 7.2E-26 T 13-10-2018 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 TOPB45_1632 f52f065f6ad0813366f16bc4b89c8357 302 PRINTS PR00100 Aspartate/ornithine carbamoyltransferase superfamily signature 253 262 7.2E-26 T 13-10-2018 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 TOPB45_1632 f52f065f6ad0813366f16bc4b89c8357 302 PRINTS PR00100 Aspartate/ornithine carbamoyltransferase superfamily signature 265 288 7.2E-26 T 13-10-2018 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 TOPB45_1632 f52f065f6ad0813366f16bc4b89c8357 302 PRINTS PR00100 Aspartate/ornithine carbamoyltransferase superfamily signature 128 139 7.2E-26 T 13-10-2018 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 TOPB45_1632 f52f065f6ad0813366f16bc4b89c8357 302 SUPERFAMILY SSF53671 2 301 1.44E-102 T 13-10-2018 IPR036901 Aspartate/ornithine carbamoyltransferase superfamily GO:0006520|GO:0016597|GO:0016743 TOPB45_1632 f52f065f6ad0813366f16bc4b89c8357 302 PRINTS PR00102 Ornithine carbamoyltransferase signature 117 131 4.3E-29 T 13-10-2018 IPR002292 Ornithine/putrescine carbamoyltransferase GO:0016743 KEGG: 00220+2.1.3.3|MetaCyc: PWY-4981|MetaCyc: PWY-4984|MetaCyc: PWY-7400|Reactome: R-HSA-1268020|Reactome: R-HSA-70635 TOPB45_1632 f52f065f6ad0813366f16bc4b89c8357 302 PRINTS PR00102 Ornithine carbamoyltransferase signature 44 58 4.3E-29 T 13-10-2018 IPR002292 Ornithine/putrescine carbamoyltransferase GO:0016743 KEGG: 00220+2.1.3.3|MetaCyc: PWY-4981|MetaCyc: PWY-4984|MetaCyc: PWY-7400|Reactome: R-HSA-1268020|Reactome: R-HSA-70635 TOPB45_1632 f52f065f6ad0813366f16bc4b89c8357 302 PRINTS PR00102 Ornithine carbamoyltransferase signature 77 90 4.3E-29 T 13-10-2018 IPR002292 Ornithine/putrescine carbamoyltransferase GO:0016743 KEGG: 00220+2.1.3.3|MetaCyc: PWY-4981|MetaCyc: PWY-4984|MetaCyc: PWY-7400|Reactome: R-HSA-1268020|Reactome: R-HSA-70635 TOPB45_1632 f52f065f6ad0813366f16bc4b89c8357 302 PRINTS PR00102 Ornithine carbamoyltransferase signature 217 227 4.3E-29 T 13-10-2018 IPR002292 Ornithine/putrescine carbamoyltransferase GO:0016743 KEGG: 00220+2.1.3.3|MetaCyc: PWY-4981|MetaCyc: PWY-4984|MetaCyc: PWY-7400|Reactome: R-HSA-1268020|Reactome: R-HSA-70635 TOPB45_1632 f52f065f6ad0813366f16bc4b89c8357 302 PRINTS PR00102 Ornithine carbamoyltransferase signature 279 290 4.3E-29 T 13-10-2018 IPR002292 Ornithine/putrescine carbamoyltransferase GO:0016743 KEGG: 00220+2.1.3.3|MetaCyc: PWY-4981|MetaCyc: PWY-4984|MetaCyc: PWY-7400|Reactome: R-HSA-1268020|Reactome: R-HSA-70635 TOPB45_1632 f52f065f6ad0813366f16bc4b89c8357 302 ProSitePatterns PS00097 Aspartate and ornithine carbamoyltransferases signature. 46 53 - T 13-10-2018 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 TOPB45_1632 f52f065f6ad0813366f16bc4b89c8357 302 Gene3D G3DSA:3.40.50.1370 4 130 6.4E-111 T 13-10-2018 IPR036901 Aspartate/ornithine carbamoyltransferase superfamily GO:0006520|GO:0016597|GO:0016743 TOPB45_1632 f52f065f6ad0813366f16bc4b89c8357 302 Pfam PF02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain 4 141 4.5E-48 T 13-10-2018 IPR006132 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding GO:0006520|GO:0016743 TOPB45_1632 f52f065f6ad0813366f16bc4b89c8357 302 TIGRFAM TIGR00658 orni_carb_tr: ornithine carbamoyltransferase 4 300 4.5E-119 T 13-10-2018 IPR002292 Ornithine/putrescine carbamoyltransferase GO:0016743 KEGG: 00220+2.1.3.3|MetaCyc: PWY-4981|MetaCyc: PWY-4984|MetaCyc: PWY-7400|Reactome: R-HSA-1268020|Reactome: R-HSA-70635 TOPB45_1632 f52f065f6ad0813366f16bc4b89c8357 302 Pfam PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain 150 298 1.5E-53 T 13-10-2018 IPR006131 Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain GO:0006520|GO:0016597|GO:0016743 TOPB45_1029 63cacd7b184f02fadc06804f9fc3adb2 631 Pfam PF01134 Glucose inhibited division protein A 8 400 1.6E-162 T 13-10-2018 IPR002218 tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG-related GO:0008033|GO:0050660 Reactome: R-HSA-6787450 TOPB45_1029 63cacd7b184f02fadc06804f9fc3adb2 631 Gene3D G3DSA:1.10.150.570 568 621 3.6E-23 T 13-10-2018 TOPB45_1029 63cacd7b184f02fadc06804f9fc3adb2 631 Gene3D G3DSA:1.10.10.1800 460 549 2.2E-19 T 13-10-2018 TOPB45_1029 63cacd7b184f02fadc06804f9fc3adb2 631 ProSitePatterns PS01280 Glucose inhibited division protein A family signature 1. 274 288 - T 13-10-2018 IPR020595 MnmG-related, conserved site Reactome: R-HSA-6787450 TOPB45_1029 63cacd7b184f02fadc06804f9fc3adb2 631 TIGRFAM TIGR00136 gidA: tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA 7 621 3.1E-273 T 13-10-2018 IPR004416 tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG GO:0002098 Reactome: R-HSA-6787450 TOPB45_1029 63cacd7b184f02fadc06804f9fc3adb2 631 SMART SM01228 545 616 2.5E-43 T 13-10-2018 TOPB45_1029 63cacd7b184f02fadc06804f9fc3adb2 631 Hamap MF_00129 tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG [mnmG]. 5 623 43.032 T 13-10-2018 IPR004416 tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG GO:0002098 Reactome: R-HSA-6787450 TOPB45_1029 63cacd7b184f02fadc06804f9fc3adb2 631 ProSitePatterns PS01281 Glucose inhibited division protein A family signature 2. 369 392 - T 13-10-2018 IPR020595 MnmG-related, conserved site Reactome: R-HSA-6787450 TOPB45_1029 63cacd7b184f02fadc06804f9fc3adb2 631 Pfam PF13932 GidA associated domain 402 614 2.5E-81 T 13-10-2018 IPR026904 GidA associated domain 3 Reactome: R-HSA-6787450 TOPB45_1029 63cacd7b184f02fadc06804f9fc3adb2 631 Gene3D G3DSA:3.50.50.60 305 459 1.8E-58 T 13-10-2018 IPR036188 FAD/NAD(P)-binding domain superfamily TOPB45_1029 63cacd7b184f02fadc06804f9fc3adb2 631 Gene3D G3DSA:3.50.50.60 1 219 3.9E-87 T 13-10-2018 IPR036188 FAD/NAD(P)-binding domain superfamily TOPB45_1029 63cacd7b184f02fadc06804f9fc3adb2 631 SUPERFAMILY SSF51905 6 262 4.23E-48 T 13-10-2018 IPR036188 FAD/NAD(P)-binding domain superfamily TOPB45_0903 57e35982116623eaed084019ef3467ba 156 Hamap MF_00161 Lipoprotein signal peptidase [lspA]. 2 155 15.014 T 13-10-2018 IPR001872 Peptidase A8, signal peptidase II GO:0004190|GO:0006508|GO:0016020 MetaCyc: PWY-7884 TOPB45_0903 57e35982116623eaed084019ef3467ba 156 Pfam PF01252 Signal peptidase (SPase) II 9 148 4.5E-34 T 13-10-2018 IPR001872 Peptidase A8, signal peptidase II GO:0004190|GO:0006508|GO:0016020 MetaCyc: PWY-7884 TOPB45_0903 57e35982116623eaed084019ef3467ba 156 ProSitePatterns PS00855 Signal peptidases II signature. 97 109 - T 13-10-2018 IPR001872 Peptidase A8, signal peptidase II GO:0004190|GO:0006508|GO:0016020 MetaCyc: PWY-7884 TOPB45_0903 57e35982116623eaed084019ef3467ba 156 TIGRFAM TIGR00077 lspA: signal peptidase II 4 150 1.8E-31 T 13-10-2018 IPR001872 Peptidase A8, signal peptidase II GO:0004190|GO:0006508|GO:0016020 MetaCyc: PWY-7884 TOPB45_0903 57e35982116623eaed084019ef3467ba 156 PRINTS PR00781 Lipoprotein signal peptidase family (A8) signature 130 146 1.1E-15 T 13-10-2018 IPR001872 Peptidase A8, signal peptidase II GO:0004190|GO:0006508|GO:0016020 MetaCyc: PWY-7884 TOPB45_0903 57e35982116623eaed084019ef3467ba 156 PRINTS PR00781 Lipoprotein signal peptidase family (A8) signature 43 51 1.1E-15 T 13-10-2018 IPR001872 Peptidase A8, signal peptidase II GO:0004190|GO:0006508|GO:0016020 MetaCyc: PWY-7884 TOPB45_0903 57e35982116623eaed084019ef3467ba 156 PRINTS PR00781 Lipoprotein signal peptidase family (A8) signature 94 109 1.1E-15 T 13-10-2018 IPR001872 Peptidase A8, signal peptidase II GO:0004190|GO:0006508|GO:0016020 MetaCyc: PWY-7884 TOPB45_0197 3368633453b911fb988b93416ac4bb30 392 Gene3D G3DSA:3.40.50.300 188 387 1.8E-56 T 13-10-2018 TOPB45_0197 3368633453b911fb988b93416ac4bb30 392 Pfam PF03266 NTPase 9 182 1.2E-34 T 13-10-2018 IPR004948 Nucleoside-triphosphatase, THEP1 type GO:0098519 KEGG: 00230+3.6.1.15|KEGG: 00730+3.6.1.15|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210 TOPB45_0197 3368633453b911fb988b93416ac4bb30 392 Hamap MF_00165 Thymidylate kinase [tmk]. 192 387 21.988 T 13-10-2018 IPR018094 Thymidylate kinase GO:0004798|GO:0005524|GO:0006233 KEGG: 00240+2.7.4.9|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7210|Reactome: R-HSA-499943 TOPB45_0197 3368633453b911fb988b93416ac4bb30 392 Gene3D G3DSA:3.40.50.300 7 186 5.3E-41 T 13-10-2018 TOPB45_0197 3368633453b911fb988b93416ac4bb30 392 SUPERFAMILY SSF52540 10 184 9.47E-14 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0197 3368633453b911fb988b93416ac4bb30 392 Pfam PF02223 Thymidylate kinase 196 375 1.2E-48 T 13-10-2018 IPR039430 Thymidylate kinase-like domain KEGG: 00240+2.7.4.9|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7210 TOPB45_0197 3368633453b911fb988b93416ac4bb30 392 TIGRFAM TIGR00041 DTMP_kinase: dTMP kinase 189 375 7.0E-50 T 13-10-2018 IPR018094 Thymidylate kinase GO:0004798|GO:0005524|GO:0006233 KEGG: 00240+2.7.4.9|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7210|Reactome: R-HSA-499943 TOPB45_0197 3368633453b911fb988b93416ac4bb30 392 SUPERFAMILY SSF52540 190 390 3.67E-46 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0197 3368633453b911fb988b93416ac4bb30 392 SMART SM00382 6 167 0.0067 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_0197 3368633453b911fb988b93416ac4bb30 392 SMART SM00382 190 324 2.7 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_0197 3368633453b911fb988b93416ac4bb30 392 ProSitePatterns PS01331 Thymidylate kinase signature. 281 293 - T 13-10-2018 IPR018095 Thymidylate kinase, conserved site GO:0004798|GO:0005524|GO:0006233 KEGG: 00240+2.7.4.9|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7210|Reactome: R-HSA-499943 TOPB45_0578 e4bd035020d9122136e47e0e4aa47b6b 249 Gene3D G3DSA:3.30.70.980 134 204 1.1E-55 T 13-10-2018 IPR026564 Transcriptional regulator TACO1-like, domain 3 Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TOPB45_0578 e4bd035020d9122136e47e0e4aa47b6b 249 Hamap MF_00693 Probable transcriptional regulatory protein YebC [yebC]. 3 239 35.344 T 13-10-2018 IPR002876 Transcriptional regulator TACO1-like Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TOPB45_0578 e4bd035020d9122136e47e0e4aa47b6b 249 SUPERFAMILY SSF75625 3 246 1.31E-91 T 13-10-2018 IPR029072 YebC-like Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TOPB45_0578 e4bd035020d9122136e47e0e4aa47b6b 249 Pfam PF01709 Transcriptional regulator 5 237 2.1E-94 T 13-10-2018 IPR002876 Transcriptional regulator TACO1-like Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TOPB45_0578 e4bd035020d9122136e47e0e4aa47b6b 249 Gene3D G3DSA:1.10.10.200 1 81 1.3E-35 T 13-10-2018 IPR017856 Integrase-like, N-terminal TOPB45_0578 e4bd035020d9122136e47e0e4aa47b6b 249 Gene3D G3DSA:3.30.70.980 86 236 1.1E-55 T 13-10-2018 IPR026564 Transcriptional regulator TACO1-like, domain 3 Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TOPB45_0578 e4bd035020d9122136e47e0e4aa47b6b 249 TIGRFAM TIGR01033 TIGR01033: DNA-binding regulatory protein, YebC/PmpR family 1 237 1.6E-97 T 13-10-2018 IPR002876 Transcriptional regulator TACO1-like Reactome: R-HSA-5628897|Reactome: R-HSA-611105 TOPB45_1096 bab71f5b62befc7726eac29d9c00ac40 585 Pfam PF04411 PD-(D/E)XK nuclease superfamily 396 541 3.2E-16 T 13-10-2018 IPR007505 PD-(D/E)XK nuclease superfamily 7 TOPB45_1096 bab71f5b62befc7726eac29d9c00ac40 585 Pfam PF09823 Domain of unknown function (DUF2357) 104 371 2.1E-30 T 13-10-2018 IPR018633 Domain of unknown function DUF2357 TOPB45_0037 0d918b2e9096b6613e6f50ccbe25c5ca 74 Pfam PF01106 NifU-like domain 6 72 1.4E-29 T 13-10-2018 IPR001075 NIF system FeS cluster assembly, NifU, C-terminal GO:0005506|GO:0016226|GO:0051536 TOPB45_0037 0d918b2e9096b6613e6f50ccbe25c5ca 74 Gene3D G3DSA:3.30.300.130 1 74 1.8E-31 T 13-10-2018 IPR034904 Fe-S cluster assembly domain superfamily TOPB45_0037 0d918b2e9096b6613e6f50ccbe25c5ca 74 ProDom PD002830 NIFU NIFU NITROGEN-FIXING C-TERMINAL FIXATION NITROGEN NIFU-LIKE DOMAIN CLUSTER HESB/YADR/YFHF:NITROGEN-FIXING 12 74 3.0E-22 T 13-10-2018 IPR001075 NIF system FeS cluster assembly, NifU, C-terminal GO:0005506|GO:0016226|GO:0051536 TOPB45_0037 0d918b2e9096b6613e6f50ccbe25c5ca 74 SUPERFAMILY SSF117916 4 74 6.15E-26 T 13-10-2018 IPR034904 Fe-S cluster assembly domain superfamily TOPB45_0291 a96aabee448923e334756cbe7ef18861 115 Pfam PF07238 PilZ domain 3 98 1.4E-12 T 13-10-2018 IPR009875 PilZ domain GO:0035438 TOPB45_0291 a96aabee448923e334756cbe7ef18861 115 SUPERFAMILY SSF141371 1 94 5.89E-13 T 13-10-2018 TOPB45_0291 a96aabee448923e334756cbe7ef18861 115 Gene3D G3DSA:2.40.10.220 1 108 5.0E-13 T 13-10-2018 TOPB45_0554 888964105d28b56952b560dc26db656a 195 Hamap MF_00321 Probable GTP-binding protein EngB [engB]. 10 192 25.754 T 13-10-2018 IPR019987 GTP-binding protein, ribosome biogenesis, YsxC GO:0005525 TOPB45_0554 888964105d28b56952b560dc26db656a 195 SUPERFAMILY SSF52540 4 192 2.39E-41 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0554 888964105d28b56952b560dc26db656a 195 TIGRFAM TIGR03598 GTPase_YsxC: ribosome biogenesis GTP-binding protein YsxC 6 188 6.0E-62 T 13-10-2018 IPR019987 GTP-binding protein, ribosome biogenesis, YsxC GO:0005525 TOPB45_0554 888964105d28b56952b560dc26db656a 195 Pfam PF01926 50S ribosome-binding GTPase 24 142 3.1E-22 T 13-10-2018 IPR006073 GTP binding domain GO:0005525 TOPB45_0554 888964105d28b56952b560dc26db656a 195 Gene3D G3DSA:3.40.50.300 1 195 9.0E-56 T 13-10-2018 TOPB45_0554 888964105d28b56952b560dc26db656a 195 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 24 189 3.9E-14 T 13-10-2018 IPR005225 Small GTP-binding protein domain GO:0005525 TOPB45_0755 97bd94af4ae10011e41485e160f7e58e 96 Gene3D G3DSA:3.30.70.330 1 96 4.4E-32 T 13-10-2018 IPR012677 Nucleotide-binding alpha-beta plait domain superfamily TOPB45_0755 97bd94af4ae10011e41485e160f7e58e 96 ProSitePatterns PS00050 Ribosomal protein L23 signature. 78 93 - T 13-10-2018 IPR001014 Ribosomal protein L23/L25, conserved site Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0755 97bd94af4ae10011e41485e160f7e58e 96 Pfam PF00276 Ribosomal protein L23 7 92 8.4E-30 T 13-10-2018 IPR013025 Ribosomal protein L25/L23 GO:0003735|GO:0005840|GO:0006412 TOPB45_0755 97bd94af4ae10011e41485e160f7e58e 96 SUPERFAMILY SSF54189 4 94 2.52E-29 T 13-10-2018 IPR012678 Ribosomal protein L23/L15e core domain superfamily GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0755 97bd94af4ae10011e41485e160f7e58e 96 Hamap MF_01369_B 50S ribosomal protein L23 [rplW]. 5 95 20.819 T 13-10-2018 IPR013025 Ribosomal protein L25/L23 GO:0003735|GO:0005840|GO:0006412 TOPB45_0230 6762fe642a947c66f62fc7cfdd5b4ad2 145 SUPERFAMILY SSF56276 29 141 1.44E-19 T 13-10-2018 IPR016067 S-adenosylmethionine decarboxylase, core GO:0004014|GO:0008295 KEGG: 00270+4.1.1.50|KEGG: 00330+4.1.1.50|MetaCyc: PWY-6834|Reactome: R-HSA-351202 TOPB45_0230 6762fe642a947c66f62fc7cfdd5b4ad2 145 Pfam PF02675 S-adenosylmethionine decarboxylase 31 137 5.2E-21 T 13-10-2018 IPR003826 S-adenosylmethionine decarboxylase family, prokaryotic GO:0004014|GO:0008295 KEGG: 00270+4.1.1.50|KEGG: 00330+4.1.1.50|MetaCyc: PWY-6834 TOPB45_0230 6762fe642a947c66f62fc7cfdd5b4ad2 145 Gene3D G3DSA:3.30.360.110 26 83 7.8E-8 T 13-10-2018 TOPB45_0230 6762fe642a947c66f62fc7cfdd5b4ad2 145 Gene3D G3DSA:3.30.160.750 90 144 7.8E-14 T 13-10-2018 TOPB45_1448 a590b3c76bfa96ceefe53f0d34acecb9 300 Gene3D G3DSA:1.10.10.10 3 93 1.3E-23 T 13-10-2018 IPR036388 Winged helix-like DNA-binding domain superfamily TOPB45_1448 a590b3c76bfa96ceefe53f0d34acecb9 300 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 5 63 9.8E-17 T 13-10-2018 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TOPB45_1448 a590b3c76bfa96ceefe53f0d34acecb9 300 Gene3D G3DSA:3.40.190.10 166 267 4.8E-35 T 13-10-2018 TOPB45_1448 a590b3c76bfa96ceefe53f0d34acecb9 300 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 20 31 1.0E-6 T 13-10-2018 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TOPB45_1448 a590b3c76bfa96ceefe53f0d34acecb9 300 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 41 52 1.0E-6 T 13-10-2018 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TOPB45_1448 a590b3c76bfa96ceefe53f0d34acecb9 300 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 31 41 1.0E-6 T 13-10-2018 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 TOPB45_1448 a590b3c76bfa96ceefe53f0d34acecb9 300 Pfam PF03466 LysR substrate binding domain 89 291 9.5E-34 T 13-10-2018 IPR005119 LysR, substrate-binding TOPB45_1448 a590b3c76bfa96ceefe53f0d34acecb9 300 SUPERFAMILY SSF53850 90 296 2.92E-31 T 13-10-2018 TOPB45_1448 a590b3c76bfa96ceefe53f0d34acecb9 300 SUPERFAMILY SSF46785 1 112 3.58E-20 T 13-10-2018 IPR036390 Winged helix DNA-binding domain superfamily TOPB45_1448 a590b3c76bfa96ceefe53f0d34acecb9 300 Gene3D G3DSA:3.40.190.10 94 289 4.8E-35 T 13-10-2018 TOPB45_0084 5727e01827dd0b1c7fc87ffb00f74981 332 Pfam PF02504 Fatty acid synthesis protein 3 316 1.1E-100 T 13-10-2018 IPR003664 Fatty acid synthesis PlsX protein GO:0003824|GO:0006633|GO:0016747 TOPB45_0084 5727e01827dd0b1c7fc87ffb00f74981 332 TIGRFAM TIGR00182 plsX: fatty acid/phospholipid synthesis protein PlsX 3 321 9.6E-100 T 13-10-2018 IPR012281 Phospholipid biosynthesis protein, PlsX-like GO:0006633 TOPB45_0084 5727e01827dd0b1c7fc87ffb00f74981 332 Hamap MF_00019 Phosphate acyltransferase [plsX]. 1 332 124.84 T 13-10-2018 IPR012281 Phospholipid biosynthesis protein, PlsX-like GO:0006633 TOPB45_0084 5727e01827dd0b1c7fc87ffb00f74981 332 Gene3D G3DSA:3.40.718.10 1 332 3.7E-123 T 13-10-2018 TOPB45_0084 5727e01827dd0b1c7fc87ffb00f74981 332 SUPERFAMILY SSF53659 1 322 1.93E-88 T 13-10-2018 TOPB45_0084 5727e01827dd0b1c7fc87ffb00f74981 332 PIRSF PIRSF002465 1 330 3.3E-113 T 13-10-2018 IPR012281 Phospholipid biosynthesis protein, PlsX-like GO:0006633 TOPB45_0296 20bcdcd3af86bf533674c8e048be4b0a 253 Pfam PF05036 Sporulation related domain 180 249 1.8E-7 T 13-10-2018 IPR007730 Sporulation-like domain GO:0042834 TOPB45_0296 20bcdcd3af86bf533674c8e048be4b0a 253 Hamap MF_02071 Endolytic peptidoglycan transglycosylase RlpA [rlpA]. 20 157 22.978 T 13-10-2018 IPR034718 Endolytic peptidoglycan transglycosylase RlpA GO:0016829 TOPB45_0296 20bcdcd3af86bf533674c8e048be4b0a 253 Gene3D G3DSA:3.30.70.1070 179 253 8.7E-6 T 13-10-2018 IPR036680 Sporulation-like domain superfamily GO:0042834 TOPB45_0296 20bcdcd3af86bf533674c8e048be4b0a 253 SUPERFAMILY SSF50685 62 153 8.72E-12 T 13-10-2018 IPR036908 RlpA-like domain superfamily TOPB45_0296 20bcdcd3af86bf533674c8e048be4b0a 253 Gene3D G3DSA:2.40.40.10 65 157 1.1E-35 T 13-10-2018 IPR036908 RlpA-like domain superfamily TOPB45_0296 20bcdcd3af86bf533674c8e048be4b0a 253 TIGRFAM TIGR00413 rlpA: rare lipoprotein A 68 159 1.0E-43 T 13-10-2018 IPR012997 Rare lipoprotein A TOPB45_0296 20bcdcd3af86bf533674c8e048be4b0a 253 Pfam PF03330 Lytic transglycolase 68 154 1.4E-24 T 13-10-2018 IPR009009 RlpA-like protein, double-psi beta-barrel domain TOPB45_0296 20bcdcd3af86bf533674c8e048be4b0a 253 SUPERFAMILY SSF110997 180 251 8.37E-9 T 13-10-2018 IPR036680 Sporulation-like domain superfamily GO:0042834 TOPB45_1320 9b0e9de8cfbdfd16e72a11f33dd91545 346 PIRSF PIRSF000876 2 346 1.1E-129 T 13-10-2018 IPR008248 Signal transduction response regulator, chemotaxis, CheB GO:0000156|GO:0000160|GO:0005737|GO:0006935|GO:0008984 TOPB45_1320 9b0e9de8cfbdfd16e72a11f33dd91545 346 SUPERFAMILY SSF52738 155 343 1.7E-65 T 13-10-2018 IPR035909 Methylesterase CheB, C-terminal TOPB45_1320 9b0e9de8cfbdfd16e72a11f33dd91545 346 SUPERFAMILY SSF52172 3 113 4.55E-30 T 13-10-2018 IPR011006 CheY-like superfamily TOPB45_1320 9b0e9de8cfbdfd16e72a11f33dd91545 346 Pfam PF00072 Response regulator receiver domain 7 113 1.3E-27 T 13-10-2018 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TOPB45_1320 9b0e9de8cfbdfd16e72a11f33dd91545 346 Pfam PF01339 CheB methylesterase 161 339 1.3E-61 T 13-10-2018 IPR000673 Signal transduction response regulator, chemotaxis, protein-glutamate methylesterase GO:0000156|GO:0000160|GO:0005737|GO:0006935|GO:0008984 TOPB45_1320 9b0e9de8cfbdfd16e72a11f33dd91545 346 Hamap MF_00099 Chemotaxis response regulator protein-glutamate methylesterase [cheB]. 5 344 37.678 T 13-10-2018 IPR008248 Signal transduction response regulator, chemotaxis, CheB GO:0000156|GO:0000160|GO:0005737|GO:0006935|GO:0008984 TOPB45_1320 9b0e9de8cfbdfd16e72a11f33dd91545 346 SMART SM00448 5 119 1.2E-28 T 13-10-2018 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TOPB45_1320 9b0e9de8cfbdfd16e72a11f33dd91545 346 Gene3D G3DSA:3.40.50.180 154 343 7.6E-72 T 13-10-2018 IPR035909 Methylesterase CheB, C-terminal TOPB45_1320 9b0e9de8cfbdfd16e72a11f33dd91545 346 Gene3D G3DSA:3.40.50.2300 2 143 9.9E-35 T 13-10-2018 TOPB45_1205 ce6d592fba877807f22672f25cceb001 464 SUPERFAMILY SSF52317 248 454 2.38E-32 T 13-10-2018 IPR029062 Class I glutamine amidotransferase-like TOPB45_1205 ce6d592fba877807f22672f25cceb001 464 SUPERFAMILY SSF52540 8 192 4.43E-30 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1205 ce6d592fba877807f22672f25cceb001 464 Pfam PF07685 CobB/CobQ-like glutamine amidotransferase domain 251 443 2.6E-36 T 13-10-2018 IPR011698 CobB/CobQ-like glutamine amidotransferase GO:0003824|GO:0009236 TOPB45_1205 ce6d592fba877807f22672f25cceb001 464 TIGRFAM TIGR00379 cobB: cobyrinic acid a,c-diamide synthase 9 456 2.8E-128 T 13-10-2018 IPR004484 Cobyrinic acid a,c-diamide synthase CbiA GO:0009236|GO:0042242 TOPB45_1205 ce6d592fba877807f22672f25cceb001 464 Gene3D G3DSA:3.40.50.880 246 463 3.9E-12 T 13-10-2018 IPR029062 Class I glutamine amidotransferase-like TOPB45_1205 ce6d592fba877807f22672f25cceb001 464 Gene3D G3DSA:3.40.50.300 9 199 8.2E-19 T 13-10-2018 TOPB45_1205 ce6d592fba877807f22672f25cceb001 464 Pfam PF01656 CobQ/CobB/MinD/ParA nucleotide binding domain 10 188 8.2E-13 T 13-10-2018 IPR002586 CobQ/CobB/MinD/ParA nucleotide binding domain TOPB45_0356 e0109711fa0233922c0aa3cc95b7e6bd 277 Pfam PF04321 RmlD substrate binding domain 1 276 1.6E-86 T 13-10-2018 IPR029903 RmlD-like substrate binding domain Reactome: R-HSA-156581|Reactome: R-HSA-5689880 TOPB45_0356 e0109711fa0233922c0aa3cc95b7e6bd 277 Gene3D G3DSA:3.40.50.720 4 266 4.1E-92 T 13-10-2018 TOPB45_0356 e0109711fa0233922c0aa3cc95b7e6bd 277 SUPERFAMILY SSF51735 1 276 2.09E-80 T 13-10-2018 IPR036291 NAD(P)-binding domain superfamily TOPB45_0356 e0109711fa0233922c0aa3cc95b7e6bd 277 TIGRFAM TIGR01214 rmlD: dTDP-4-dehydrorhamnose reductase 2 276 8.3E-84 T 13-10-2018 IPR005913 dTDP-4-dehydrorhamnose reductase family Reactome: R-HSA-156581|Reactome: R-HSA-5689880 TOPB45_0356 e0109711fa0233922c0aa3cc95b7e6bd 277 Gene3D G3DSA:3.90.25.10 159 272 4.1E-92 T 13-10-2018 TOPB45_0715 b1824ad91d97e96d652c30d4080dcbcd 148 ProSitePatterns PS00783 Ribosomal protein L13 signature. 111 133 - T 13-10-2018 IPR023563 Ribosomal protein L13, conserved site GO:0003735|GO:0005840|GO:0006412 TOPB45_0715 b1824ad91d97e96d652c30d4080dcbcd 148 Gene3D G3DSA:3.90.1180.10 7 148 1.9E-61 T 13-10-2018 IPR036899 Ribosomal protein L13 superfamily GO:0003735|GO:0005840|GO:0006412 TOPB45_0715 b1824ad91d97e96d652c30d4080dcbcd 148 Hamap MF_01366 50S ribosomal protein L13 [rplM]. 21 147 27.771 T 13-10-2018 IPR005822 Ribosomal protein L13 GO:0003735|GO:0005840|GO:0006412 TOPB45_0715 b1824ad91d97e96d652c30d4080dcbcd 148 PIRSF PIRSF002181 6 148 7.4E-52 T 13-10-2018 IPR005822 Ribosomal protein L13 GO:0003735|GO:0005840|GO:0006412 TOPB45_0715 b1824ad91d97e96d652c30d4080dcbcd 148 Pfam PF00572 Ribosomal protein L13 20 144 1.3E-55 T 13-10-2018 IPR005822 Ribosomal protein L13 GO:0003735|GO:0005840|GO:0006412 TOPB45_0715 b1824ad91d97e96d652c30d4080dcbcd 148 TIGRFAM TIGR01066 rplM_bact: ribosomal protein uL13 12 147 6.2E-62 T 13-10-2018 IPR005823 Ribosomal protein L13, bacterial-type GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0715 b1824ad91d97e96d652c30d4080dcbcd 148 SUPERFAMILY SSF52161 12 147 2.35E-55 T 13-10-2018 IPR036899 Ribosomal protein L13 superfamily GO:0003735|GO:0005840|GO:0006412 TOPB45_0593 b618f2e76523d395d3c69ff09874eb3f 648 Pfam PF05378 Hydantoinase/oxoprolinase N-terminal region 2 168 3.7E-49 T 13-10-2018 IPR008040 Hydantoinaseoxoprolinase, N-terminal Reactome: R-HSA-174403|Reactome: R-HSA-5578998 TOPB45_0593 b618f2e76523d395d3c69ff09874eb3f 648 Pfam PF01968 Hydantoinase/oxoprolinase 191 466 2.8E-95 T 13-10-2018 IPR002821 Hydantoinase A/oxoprolinase GO:0016787 Reactome: R-HSA-174403|Reactome: R-HSA-5578998 TOPB45_1408 84bc444e658353308b3cfe1ddbffcdc7 673 SMART SM00382 414 549 1.0E-4 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_1408 84bc444e658353308b3cfe1ddbffcdc7 673 Pfam PF05157 Type II secretion system (T2SS), protein E, N-terminal domain 146 246 1.2E-5 T 13-10-2018 IPR007831 General secretory system II, protein E, N-terminal TOPB45_1408 84bc444e658353308b3cfe1ddbffcdc7 673 Gene3D G3DSA:3.40.50.300 389 673 1.2E-109 T 13-10-2018 TOPB45_1408 84bc444e658353308b3cfe1ddbffcdc7 673 Pfam PF00437 Type II/IV secretion system protein 284 553 6.6E-72 T 13-10-2018 IPR001482 Type II/IV secretion system protein TOPB45_1408 84bc444e658353308b3cfe1ddbffcdc7 673 SUPERFAMILY SSF160246 106 244 2.62E-8 T 13-10-2018 IPR037257 General secretory system II, protein E, N-terminal superfamily TOPB45_1408 84bc444e658353308b3cfe1ddbffcdc7 673 SUPERFAMILY SSF52540 257 670 1.8E-88 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1408 84bc444e658353308b3cfe1ddbffcdc7 673 Gene3D G3DSA:3.30.450.90 251 387 2.9E-40 T 13-10-2018 TOPB45_0570 31f986b03e77a70ffc30af07fa6a081f 69 Gene3D G3DSA:3.40.109.10 22 69 4.2E-8 T 13-10-2018 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 TOPB45_0892 dad404c738a18774a807f069eb1cc4a8 238 Pfam PF01925 Sulfite exporter TauE/SafE 7 181 3.7E-24 T 13-10-2018 IPR002781 Transmembrane protein TauE-like GO:0016021 TOPB45_0239 e13f8931eae6a3e6d97c8321cb2b2ed2 624 Gene3D G3DSA:1.10.3810.10 49 246 8.5E-80 T 13-10-2018 IPR036950 Penicillin binding protein transglycosylase domain KEGG: 00550+2.4.1.129|MetaCyc: PWY-5265|MetaCyc: PWY-6385|MetaCyc: PWY-6470|MetaCyc: PWY-6471 TOPB45_0239 e13f8931eae6a3e6d97c8321cb2b2ed2 624 TIGRFAM TIGR02074 PBP_1a_fam: penicillin-binding protein, 1A family 66 597 7.8E-186 T 13-10-2018 TOPB45_0239 e13f8931eae6a3e6d97c8321cb2b2ed2 624 Pfam PF00912 Transglycosylase 56 230 2.6E-65 T 13-10-2018 IPR001264 Glycosyl transferase, family 51 KEGG: 00550+2.4.1.129|MetaCyc: PWY-5265|MetaCyc: PWY-6385|MetaCyc: PWY-6470|MetaCyc: PWY-6471 TOPB45_0239 e13f8931eae6a3e6d97c8321cb2b2ed2 624 Gene3D G3DSA:3.40.710.10 252 623 2.5E-114 T 13-10-2018 TOPB45_0239 e13f8931eae6a3e6d97c8321cb2b2ed2 624 Pfam PF00905 Penicillin binding protein transpeptidase domain 322 569 7.6E-37 T 13-10-2018 IPR001460 Penicillin-binding protein, transpeptidase GO:0008658 TOPB45_0239 e13f8931eae6a3e6d97c8321cb2b2ed2 624 SUPERFAMILY SSF56601 212 612 4.23E-116 T 13-10-2018 IPR012338 Beta-lactamase/transpeptidase-like TOPB45_0239 e13f8931eae6a3e6d97c8321cb2b2ed2 624 SUPERFAMILY SSF53955 43 258 4.78E-79 T 13-10-2018 IPR023346 Lysozyme-like domain superfamily TOPB45_0766 098d84b86a9595535c0070023bc11f08 61 Gene3D G3DSA:4.10.830.10 1 61 4.6E-30 T 13-10-2018 TOPB45_0766 098d84b86a9595535c0070023bc11f08 61 Pfam PF00253 Ribosomal protein S14p/S29e 10 60 3.9E-25 T 13-10-2018 IPR001209 Ribosomal protein S14 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0766 098d84b86a9595535c0070023bc11f08 61 Hamap MF_01364_B 30S ribosomal protein S14 type Z [rpsZ]. 1 61 25.813 T 13-10-2018 IPR023053 Ribosomal protein S14, type Z TOPB45_0766 098d84b86a9595535c0070023bc11f08 61 SUPERFAMILY SSF57716 8 61 1.64E-20 T 13-10-2018 TOPB45_0766 098d84b86a9595535c0070023bc11f08 61 ProSitePatterns PS00527 Ribosomal protein S14 signature. 23 45 - T 13-10-2018 IPR018271 Ribosomal protein S14, conserved site GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_1041 f955bd575088f037c3a37e6ee2453e14 302 SUPERFAMILY SSF52540 43 294 1.2E-27 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1041 f955bd575088f037c3a37e6ee2453e14 302 Pfam PF06745 KaiC 44 296 1.9E-64 T 13-10-2018 IPR014774 KaiC-like domain TOPB45_1041 f955bd575088f037c3a37e6ee2453e14 302 TIGRFAM TIGR03878 thermo_KaiC_2: KaiC domain protein, AF_0795 family 41 299 9.5E-141 T 13-10-2018 IPR022373 KaiC domain-containing protein TOPB45_1041 f955bd575088f037c3a37e6ee2453e14 302 Gene3D G3DSA:3.40.50.300 34 297 1.0E-36 T 13-10-2018 TOPB45_1533 904e2305494dd8816945c1142cfb01d6 636 PRINTS PR00301 70kDa heat shock protein signature 57 65 1.0E-76 T 13-10-2018 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 TOPB45_1533 904e2305494dd8816945c1142cfb01d6 636 PRINTS PR00301 70kDa heat shock protein signature 6 19 1.0E-76 T 13-10-2018 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 TOPB45_1533 904e2305494dd8816945c1142cfb01d6 636 PRINTS PR00301 70kDa heat shock protein signature 332 348 1.0E-76 T 13-10-2018 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 TOPB45_1533 904e2305494dd8816945c1142cfb01d6 636 PRINTS PR00301 70kDa heat shock protein signature 386 405 1.0E-76 T 13-10-2018 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 TOPB45_1533 904e2305494dd8816945c1142cfb01d6 636 PRINTS PR00301 70kDa heat shock protein signature 467 483 1.0E-76 T 13-10-2018 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 TOPB45_1533 904e2305494dd8816945c1142cfb01d6 636 PRINTS PR00301 70kDa heat shock protein signature 200 210 1.0E-76 T 13-10-2018 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 TOPB45_1533 904e2305494dd8816945c1142cfb01d6 636 PRINTS PR00301 70kDa heat shock protein signature 34 46 1.0E-76 T 13-10-2018 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 TOPB45_1533 904e2305494dd8816945c1142cfb01d6 636 PRINTS PR00301 70kDa heat shock protein signature 363 383 1.0E-76 T 13-10-2018 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 TOPB45_1533 904e2305494dd8816945c1142cfb01d6 636 PRINTS PR00301 70kDa heat shock protein signature 141 161 1.0E-76 T 13-10-2018 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 TOPB45_1533 904e2305494dd8816945c1142cfb01d6 636 Gene3D G3DSA:2.60.34.10 381 521 7.7E-65 T 13-10-2018 IPR029047 Heat shock protein 70kD, peptide-binding domain superfamily Reactome: R-HSA-3371453 TOPB45_1533 904e2305494dd8816945c1142cfb01d6 636 TIGRFAM TIGR02350 prok_dnaK: chaperone protein DnaK 7 601 4.6E-296 T 13-10-2018 IPR012725 Chaperone DnaK GO:0005524|GO:0006457|GO:0051082 Reactome: R-HSA-1268020|Reactome: R-HSA-3371453|Reactome: R-HSA-8949613|Reactome: R-HSA-8950505 TOPB45_1533 904e2305494dd8816945c1142cfb01d6 636 ProSitePatterns PS00297 Heat shock hsp70 proteins family signature 1. 10 17 - T 13-10-2018 IPR018181 Heat shock protein 70, conserved site Reactome: R-HSA-3371453 TOPB45_1533 904e2305494dd8816945c1142cfb01d6 636 SUPERFAMILY SSF100920 382 538 3.79E-64 T 13-10-2018 IPR029047 Heat shock protein 70kD, peptide-binding domain superfamily Reactome: R-HSA-3371453 TOPB45_1533 904e2305494dd8816945c1142cfb01d6 636 Gene3D G3DSA:1.20.1270.10 522 605 3.9E-26 T 13-10-2018 IPR029048 Heat shock protein 70kD, C-terminal domain superfamily Reactome: R-HSA-3371453 TOPB45_1533 904e2305494dd8816945c1142cfb01d6 636 Gene3D G3DSA:3.30.420.40 8 377 4.2E-163 T 13-10-2018 TOPB45_1533 904e2305494dd8816945c1142cfb01d6 636 Hamap MF_00332 Chaperone protein DnaK [dnaK]. 4 635 37.428 T 13-10-2018 IPR012725 Chaperone DnaK GO:0005524|GO:0006457|GO:0051082 Reactome: R-HSA-1268020|Reactome: R-HSA-3371453|Reactome: R-HSA-8949613|Reactome: R-HSA-8950505 TOPB45_1533 904e2305494dd8816945c1142cfb01d6 636 ProSitePatterns PS00329 Heat shock hsp70 proteins family signature 2. 194 207 - T 13-10-2018 IPR018181 Heat shock protein 70, conserved site Reactome: R-HSA-3371453 TOPB45_1533 904e2305494dd8816945c1142cfb01d6 636 Gene3D G3DSA:3.30.420.40 183 364 4.2E-163 T 13-10-2018 TOPB45_1533 904e2305494dd8816945c1142cfb01d6 636 ProSitePatterns PS01036 Heat shock hsp70 proteins family signature 3. 335 349 - T 13-10-2018 IPR018181 Heat shock protein 70, conserved site Reactome: R-HSA-3371453 TOPB45_1533 904e2305494dd8816945c1142cfb01d6 636 SUPERFAMILY SSF53067 7 187 3.56E-67 T 13-10-2018 TOPB45_1533 904e2305494dd8816945c1142cfb01d6 636 Gene3D G3DSA:3.90.640.10 227 314 4.2E-163 T 13-10-2018 TOPB45_1533 904e2305494dd8816945c1142cfb01d6 636 SUPERFAMILY SSF100934 505 608 2.09E-19 T 13-10-2018 IPR029048 Heat shock protein 70kD, C-terminal domain superfamily Reactome: R-HSA-3371453 TOPB45_1533 904e2305494dd8816945c1142cfb01d6 636 Pfam PF00012 Hsp70 protein 7 601 5.0E-267 T 13-10-2018 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 TOPB45_1533 904e2305494dd8816945c1142cfb01d6 636 SUPERFAMILY SSF53067 189 380 1.71E-68 T 13-10-2018 TOPB45_0399 6a3ac8ef850e135a3d3e73e76d465f41 300 Gene3D G3DSA:3.40.50.720 6 269 4.3E-117 T 13-10-2018 TOPB45_0399 6a3ac8ef850e135a3d3e73e76d465f41 300 ProSitePatterns PS00767 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 2. 270 278 - T 13-10-2018 IPR020867 Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site GO:0003824|GO:0055114 KEGG: 00670+1.5.1.5+3.5.4.9|KEGG: 00720+1.5.1.5+3.5.4.9|MetaCyc: PWY-1722|MetaCyc: PWY-2201|MetaCyc: PWY-3841|MetaCyc: PWY-5030|MetaCyc: PWY-5497|MetaCyc: PWY-6613|MetaCyc: PWY-7909|Reactome: R-HSA-196757 TOPB45_0399 6a3ac8ef850e135a3d3e73e76d465f41 300 Hamap MF_01576 Bifunctional protein FolD [folD]. 3 293 40.514 T 13-10-2018 IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase GO:0004488|GO:0055114 KEGG: 00670+1.5.1.5+3.5.4.9|KEGG: 00720+1.5.1.5+3.5.4.9|MetaCyc: PWY-1722|MetaCyc: PWY-2201|MetaCyc: PWY-3841|MetaCyc: PWY-5030|MetaCyc: PWY-5497|MetaCyc: PWY-6613|MetaCyc: PWY-7909|Reactome: R-HSA-196757 TOPB45_0399 6a3ac8ef850e135a3d3e73e76d465f41 300 Pfam PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 124 292 1.6E-70 T 13-10-2018 IPR020631 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain GO:0004488 KEGG: 00670+1.5.1.5+3.5.4.9|KEGG: 00720+1.5.1.5+3.5.4.9|MetaCyc: PWY-1722|MetaCyc: PWY-2201|MetaCyc: PWY-3841|MetaCyc: PWY-5030|MetaCyc: PWY-5497|MetaCyc: PWY-6613|MetaCyc: PWY-7909|Reactome: R-HSA-196757 TOPB45_0399 6a3ac8ef850e135a3d3e73e76d465f41 300 Pfam PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 5 121 4.4E-42 T 13-10-2018 IPR020630 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain GO:0004488|GO:0055114 KEGG: 00670+1.5.1.5+3.5.4.9|KEGG: 00720+1.5.1.5+3.5.4.9|MetaCyc: PWY-1722|MetaCyc: PWY-2201|MetaCyc: PWY-3841|MetaCyc: PWY-5030|MetaCyc: PWY-5497|MetaCyc: PWY-6613|MetaCyc: PWY-7909|Reactome: R-HSA-196757 TOPB45_0399 6a3ac8ef850e135a3d3e73e76d465f41 300 Gene3D G3DSA:3.40.50.10860 8 286 4.3E-117 T 13-10-2018 TOPB45_0399 6a3ac8ef850e135a3d3e73e76d465f41 300 PRINTS PR00085 Tetrahydrofolate dehydrogenase/cyclohydrolase family signature 155 175 2.8E-83 T 13-10-2018 IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase GO:0004488|GO:0055114 KEGG: 00670+1.5.1.5+3.5.4.9|KEGG: 00720+1.5.1.5+3.5.4.9|MetaCyc: PWY-1722|MetaCyc: PWY-2201|MetaCyc: PWY-3841|MetaCyc: PWY-5030|MetaCyc: PWY-5497|MetaCyc: PWY-6613|MetaCyc: PWY-7909|Reactome: R-HSA-196757 TOPB45_0399 6a3ac8ef850e135a3d3e73e76d465f41 300 PRINTS PR00085 Tetrahydrofolate dehydrogenase/cyclohydrolase family signature 209 238 2.8E-83 T 13-10-2018 IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase GO:0004488|GO:0055114 KEGG: 00670+1.5.1.5+3.5.4.9|KEGG: 00720+1.5.1.5+3.5.4.9|MetaCyc: PWY-1722|MetaCyc: PWY-2201|MetaCyc: PWY-3841|MetaCyc: PWY-5030|MetaCyc: PWY-5497|MetaCyc: PWY-6613|MetaCyc: PWY-7909|Reactome: R-HSA-196757 TOPB45_0399 6a3ac8ef850e135a3d3e73e76d465f41 300 PRINTS PR00085 Tetrahydrofolate dehydrogenase/cyclohydrolase family signature 110 131 2.8E-83 T 13-10-2018 IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase GO:0004488|GO:0055114 KEGG: 00670+1.5.1.5+3.5.4.9|KEGG: 00720+1.5.1.5+3.5.4.9|MetaCyc: PWY-1722|MetaCyc: PWY-2201|MetaCyc: PWY-3841|MetaCyc: PWY-5030|MetaCyc: PWY-5497|MetaCyc: PWY-6613|MetaCyc: PWY-7909|Reactome: R-HSA-196757 TOPB45_0399 6a3ac8ef850e135a3d3e73e76d465f41 300 PRINTS PR00085 Tetrahydrofolate dehydrogenase/cyclohydrolase family signature 75 102 2.8E-83 T 13-10-2018 IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase GO:0004488|GO:0055114 KEGG: 00670+1.5.1.5+3.5.4.9|KEGG: 00720+1.5.1.5+3.5.4.9|MetaCyc: PWY-1722|MetaCyc: PWY-2201|MetaCyc: PWY-3841|MetaCyc: PWY-5030|MetaCyc: PWY-5497|MetaCyc: PWY-6613|MetaCyc: PWY-7909|Reactome: R-HSA-196757 TOPB45_0399 6a3ac8ef850e135a3d3e73e76d465f41 300 PRINTS PR00085 Tetrahydrofolate dehydrogenase/cyclohydrolase family signature 249 265 2.8E-83 T 13-10-2018 IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase GO:0004488|GO:0055114 KEGG: 00670+1.5.1.5+3.5.4.9|KEGG: 00720+1.5.1.5+3.5.4.9|MetaCyc: PWY-1722|MetaCyc: PWY-2201|MetaCyc: PWY-3841|MetaCyc: PWY-5030|MetaCyc: PWY-5497|MetaCyc: PWY-6613|MetaCyc: PWY-7909|Reactome: R-HSA-196757 TOPB45_0399 6a3ac8ef850e135a3d3e73e76d465f41 300 PRINTS PR00085 Tetrahydrofolate dehydrogenase/cyclohydrolase family signature 34 56 2.8E-83 T 13-10-2018 IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase GO:0004488|GO:0055114 KEGG: 00670+1.5.1.5+3.5.4.9|KEGG: 00720+1.5.1.5+3.5.4.9|MetaCyc: PWY-1722|MetaCyc: PWY-2201|MetaCyc: PWY-3841|MetaCyc: PWY-5030|MetaCyc: PWY-5497|MetaCyc: PWY-6613|MetaCyc: PWY-7909|Reactome: R-HSA-196757 TOPB45_0399 6a3ac8ef850e135a3d3e73e76d465f41 300 PRINTS PR00085 Tetrahydrofolate dehydrogenase/cyclohydrolase family signature 266 284 2.8E-83 T 13-10-2018 IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase GO:0004488|GO:0055114 KEGG: 00670+1.5.1.5+3.5.4.9|KEGG: 00720+1.5.1.5+3.5.4.9|MetaCyc: PWY-1722|MetaCyc: PWY-2201|MetaCyc: PWY-3841|MetaCyc: PWY-5030|MetaCyc: PWY-5497|MetaCyc: PWY-6613|MetaCyc: PWY-7909|Reactome: R-HSA-196757 TOPB45_0399 6a3ac8ef850e135a3d3e73e76d465f41 300 ProSitePatterns PS00766 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 1. 76 101 - T 13-10-2018 IPR020867 Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site GO:0003824|GO:0055114 KEGG: 00670+1.5.1.5+3.5.4.9|KEGG: 00720+1.5.1.5+3.5.4.9|MetaCyc: PWY-1722|MetaCyc: PWY-2201|MetaCyc: PWY-3841|MetaCyc: PWY-5030|MetaCyc: PWY-5497|MetaCyc: PWY-6613|MetaCyc: PWY-7909|Reactome: R-HSA-196757 TOPB45_0399 6a3ac8ef850e135a3d3e73e76d465f41 300 SUPERFAMILY SSF51735 123 290 9.74E-48 T 13-10-2018 IPR036291 NAD(P)-binding domain superfamily TOPB45_0399 6a3ac8ef850e135a3d3e73e76d465f41 300 SUPERFAMILY SSF53223 1 122 1.92E-43 T 13-10-2018 TOPB45_1088 12d6c8c32bde5b75b3fff4d12ae50f87 159 Pfam PF07813 LTXXQ motif family protein 60 150 8.5E-7 T 13-10-2018 IPR012899 LTXXQ motif family protein GO:0042597 TOPB45_1088 12d6c8c32bde5b75b3fff4d12ae50f87 159 Gene3D G3DSA:1.20.120.1490 57 156 4.9E-12 T 13-10-2018 TOPB45_0901 c5b04773544469125aaff30772e9c6ec 134 Pfam PF01925 Sulfite exporter TauE/SafE 14 127 1.9E-21 T 13-10-2018 IPR002781 Transmembrane protein TauE-like GO:0016021 TOPB45_1018 f8db329f5c7de3f69fde6d78762ba3e3 184 Gene3D G3DSA:1.10.132.20 11 181 6.0E-68 T 13-10-2018 TOPB45_1018 f8db329f5c7de3f69fde6d78762ba3e3 184 Hamap MF_00040 Ribosome-recycling factor [frr]. 2 184 26.225 T 13-10-2018 IPR002661 Ribosome recycling factor GO:0006412 Reactome: R-HSA-5419276 TOPB45_1018 f8db329f5c7de3f69fde6d78762ba3e3 184 SUPERFAMILY SSF55194 2 182 1.7E-67 T 13-10-2018 IPR036191 RRF superfamily Reactome: R-HSA-5419276 TOPB45_1018 f8db329f5c7de3f69fde6d78762ba3e3 184 TIGRFAM TIGR00496 frr: ribosome recycling factor 9 182 2.3E-65 T 13-10-2018 IPR002661 Ribosome recycling factor GO:0006412 Reactome: R-HSA-5419276 TOPB45_1018 f8db329f5c7de3f69fde6d78762ba3e3 184 Pfam PF01765 Ribosome recycling factor 19 182 3.1E-62 T 13-10-2018 IPR023584 Ribosome recycling factor domain Reactome: R-HSA-5419276 TOPB45_1018 f8db329f5c7de3f69fde6d78762ba3e3 184 Gene3D G3DSA:3.30.1360.40 30 104 6.0E-68 T 13-10-2018 TOPB45_1470 dffe6699fae800561922d19197b5d7c3 286 SUPERFAMILY SSF141986 135 275 9.02E-30 T 13-10-2018 IPR027461 LD-carboxypeptidase A, C-terminal domain superfamily TOPB45_1470 dffe6699fae800561922d19197b5d7c3 286 Pfam PF02016 LD-carboxypeptidase 7 269 3.0E-51 T 13-10-2018 IPR003507 Peptidase family S66 TOPB45_1470 dffe6699fae800561922d19197b5d7c3 286 PIRSF PIRSF028757 1 285 5.2E-52 T 13-10-2018 IPR003507 Peptidase family S66 TOPB45_1470 dffe6699fae800561922d19197b5d7c3 286 Gene3D G3DSA:3.50.30.60 147 281 1.7E-26 T 13-10-2018 IPR027461 LD-carboxypeptidase A, C-terminal domain superfamily TOPB45_1470 dffe6699fae800561922d19197b5d7c3 286 Gene3D G3DSA:3.40.50.10740 1 146 3.5E-20 T 13-10-2018 IPR027478 Murein tetrapeptide carboxypeptidase, N-terminal TOPB45_1470 dffe6699fae800561922d19197b5d7c3 286 SUPERFAMILY SSF52317 5 148 1.46E-19 T 13-10-2018 IPR029062 Class I glutamine amidotransferase-like TOPB45_1224 997b0a5b7eb580d6f80d1da351b9a059 842 Gene3D G3DSA:1.10.3210.30 14 181 2.3E-13 T 13-10-2018 IPR038257 CRISPR-associated Cas3-type HD domain superfamily TOPB45_1224 997b0a5b7eb580d6f80d1da351b9a059 842 SMART SM00490 538 628 5.0E-5 T 13-10-2018 IPR001650 Helicase, C-terminal TOPB45_1224 997b0a5b7eb580d6f80d1da351b9a059 842 SUPERFAMILY SSF52540 286 628 2.02E-31 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1224 997b0a5b7eb580d6f80d1da351b9a059 842 TIGRFAM TIGR01596 cas3_HD: CRISPR-associated endonuclease Cas3-HD 17 241 7.2E-24 T 13-10-2018 IPR006483 CRISPR-associated Cas3-type HD domain TOPB45_1224 997b0a5b7eb580d6f80d1da351b9a059 842 Pfam PF00271 Helicase conserved C-terminal domain 514 626 2.5E-8 T 13-10-2018 IPR001650 Helicase, C-terminal TOPB45_1224 997b0a5b7eb580d6f80d1da351b9a059 842 TIGRFAM TIGR01587 cas3_core: CRISPR-associated helicase Cas3 290 627 2.2E-68 T 13-10-2018 IPR006474 Helicase Cas3, CRISPR-associated, core TOPB45_1224 997b0a5b7eb580d6f80d1da351b9a059 842 SMART SM00487 267 484 0.0015 T 13-10-2018 IPR014001 Helicase superfamily 1/2, ATP-binding domain TOPB45_1224 997b0a5b7eb580d6f80d1da351b9a059 842 Gene3D G3DSA:3.40.50.300 495 671 3.3E-14 T 13-10-2018 TOPB45_1224 997b0a5b7eb580d6f80d1da351b9a059 842 Gene3D G3DSA:3.40.50.300 261 477 4.6E-11 T 13-10-2018 TOPB45_0098 6d4aecbf76bea5397910f7b60350b5cc 171 SUPERFAMILY SSF143243 3 156 1.01E-52 T 13-10-2018 IPR037232 NADH:ubiquinone oxidoreductase, 30kDa subunit superfamily Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_0098 6d4aecbf76bea5397910f7b60350b5cc 171 Pfam PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 29 149 5.5E-44 T 13-10-2018 IPR001268 NADH:ubiquinone oxidoreductase, 30kDa subunit GO:0008137|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_0098 6d4aecbf76bea5397910f7b60350b5cc 171 TIGRFAM TIGR01961 NuoC_fam: NADH (or F420H2) dehydrogenase, subunit C 29 149 3.4E-44 T 13-10-2018 IPR010218 NADH dehydrogenase, subunit C GO:0016651|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_0098 6d4aecbf76bea5397910f7b60350b5cc 171 ProDom PD001581 OXIDOREDUCTASE SUBUNIT NADH DEHYDROGENASE CHAIN C NAD DEHYDROGENASE UBIQUINONE F420H2 100 149 2.0E-15 T 13-10-2018 IPR001268 NADH:ubiquinone oxidoreductase, 30kDa subunit GO:0008137|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_0098 6d4aecbf76bea5397910f7b60350b5cc 171 Gene3D G3DSA:3.30.460.80 1 131 4.0E-39 T 13-10-2018 IPR037232 NADH:ubiquinone oxidoreductase, 30kDa subunit superfamily Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_0098 6d4aecbf76bea5397910f7b60350b5cc 171 Hamap MF_01357 NAD(P)H-quinone oxidoreductase subunit J, chloroplastic [ndhJ]. 4 159 28.519 T 13-10-2018 IPR010218 NADH dehydrogenase, subunit C GO:0016651|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_0098 6d4aecbf76bea5397910f7b60350b5cc 171 ProSitePatterns PS00542 Respiratory chain NADH dehydrogenase 30 Kd subunit signature. 112 133 - T 13-10-2018 IPR020396 NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site GO:0016651|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_1117 53ce627e10cbe4a02bc100287f02733e 86 SUPERFAMILY SSF143430 1 74 3.79E-18 T 13-10-2018 TOPB45_1117 53ce627e10cbe4a02bc100287f02733e 86 Gene3D G3DSA:3.30.70.240 1 67 3.7E-19 T 13-10-2018 TOPB45_1117 53ce627e10cbe4a02bc100287f02733e 86 TIGRFAM TIGR01573 cas2: CRISPR-associated endonuclease Cas2 1 68 1.0E-10 T 13-10-2018 IPR021127 CRISPR-associated endonuclease Cas2 GO:0004521|GO:0043571 TOPB45_1117 53ce627e10cbe4a02bc100287f02733e 86 Pfam PF09827 CRISPR associated protein Cas2 1 68 4.1E-16 T 13-10-2018 IPR019199 Virulence-associated protein D / CRISPR associated protein Cas2 TOPB45_1117 53ce627e10cbe4a02bc100287f02733e 86 Hamap MF_01471 CRISPR-associated endoribonuclease Cas2 [cas2]. 1 84 13.205 T 13-10-2018 IPR021127 CRISPR-associated endonuclease Cas2 GO:0004521|GO:0043571 TOPB45_0365 536ff39c46f0310810992029abf3e9ab 807 SUPERFAMILY SSF142984 547 584 3.53E-5 T 13-10-2018 TOPB45_0365 536ff39c46f0310810992029abf3e9ab 807 Pfam PF02563 Polysaccharide biosynthesis/export protein 209 281 3.6E-17 T 13-10-2018 IPR003715 Polysaccharide export protein GO:0015159|GO:0015774|GO:0016020 TOPB45_0365 536ff39c46f0310810992029abf3e9ab 807 Gene3D G3DSA:3.10.560.10 687 774 2.5E-12 T 13-10-2018 TOPB45_0365 536ff39c46f0310810992029abf3e9ab 807 Gene3D G3DSA:3.10.560.10 370 446 9.1E-10 T 13-10-2018 TOPB45_0365 536ff39c46f0310810992029abf3e9ab 807 Gene3D G3DSA:3.10.560.10 450 539 1.5E-14 T 13-10-2018 TOPB45_0365 536ff39c46f0310810992029abf3e9ab 807 Gene3D G3DSA:3.10.560.10 282 367 3.0E-18 T 13-10-2018 TOPB45_0365 536ff39c46f0310810992029abf3e9ab 807 Gene3D G3DSA:3.30.1950.10 214 281 4.9E-8 T 13-10-2018 TOPB45_0365 536ff39c46f0310810992029abf3e9ab 807 Pfam PF10531 SLBB domain 454 505 2.6E-9 T 13-10-2018 IPR019554 Soluble ligand binding domain Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_0365 536ff39c46f0310810992029abf3e9ab 807 Pfam PF10531 SLBB domain 549 589 1.9E-11 T 13-10-2018 IPR019554 Soluble ligand binding domain Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_0365 536ff39c46f0310810992029abf3e9ab 807 Pfam PF10531 SLBB domain 372 418 6.5E-7 T 13-10-2018 IPR019554 Soluble ligand binding domain Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_0365 536ff39c46f0310810992029abf3e9ab 807 Pfam PF10531 SLBB domain 288 337 3.8E-7 T 13-10-2018 IPR019554 Soluble ligand binding domain Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_0365 536ff39c46f0310810992029abf3e9ab 807 Pfam PF06251 Capsule biosynthesis GfcC 619 740 2.1E-6 T 13-10-2018 IPR010425 Domain of unknown function DUF1017 TOPB45_1591 7d8d29403927cfacc7e20d806f705c6b 304 Hamap MF_00568 Quinolinate synthase A [nadA]. 4 303 42.64 T 13-10-2018 IPR023066 Quinolinate synthase A, type 2 GO:0016765 MetaCyc: PWY-5316|MetaCyc: PWY-7342 TOPB45_1591 7d8d29403927cfacc7e20d806f705c6b 304 Pfam PF02445 Quinolinate synthetase A protein 8 302 8.7E-114 T 13-10-2018 IPR003473 Quinolinate synthetase A GO:0008987|GO:0009435|GO:0051539 MetaCyc: PWY-5316|MetaCyc: PWY-7342 TOPB45_1591 7d8d29403927cfacc7e20d806f705c6b 304 Gene3D G3DSA:3.40.50.10800 8 284 8.5E-113 T 13-10-2018 TOPB45_1591 7d8d29403927cfacc7e20d806f705c6b 304 TIGRFAM TIGR00550 nadA: quinolinate synthetase complex, A subunit 2 303 8.1E-102 T 13-10-2018 IPR003473 Quinolinate synthetase A GO:0008987|GO:0009435|GO:0051539 MetaCyc: PWY-5316|MetaCyc: PWY-7342 TOPB45_1591 7d8d29403927cfacc7e20d806f705c6b 304 Gene3D G3DSA:3.40.50.10800 172 259 8.5E-113 T 13-10-2018 TOPB45_1591 7d8d29403927cfacc7e20d806f705c6b 304 SUPERFAMILY SSF142754 5 303 2.75E-110 T 13-10-2018 IPR036094 Quinolinate synthetase A superfamily GO:0008987|GO:0009435|GO:0051539 MetaCyc: PWY-5316|MetaCyc: PWY-7342 TOPB45_1591 7d8d29403927cfacc7e20d806f705c6b 304 Gene3D G3DSA:3.40.50.10800 88 302 8.5E-113 T 13-10-2018 TOPB45_0166 c31ad6af6a6282f7ce4e894b73abad61 171 SUPERFAMILY SSF160369 2 167 4.45E-49 T 13-10-2018 TOPB45_0166 c31ad6af6a6282f7ce4e894b73abad61 171 Gene3D G3DSA:3.30.70.1730 1 128 2.0E-36 T 13-10-2018 TOPB45_0166 c31ad6af6a6282f7ce4e894b73abad61 171 Pfam PF00466 Ribosomal protein L10 2 94 9.0E-27 T 13-10-2018 IPR001790 Ribosomal protein L10P GO:0005622|GO:0042254 TOPB45_0166 c31ad6af6a6282f7ce4e894b73abad61 171 Hamap MF_00362 50S ribosomal protein L10 [rplJ]. 1 156 22.336 T 13-10-2018 IPR022973 Ribosomal protein L10 TOPB45_0166 c31ad6af6a6282f7ce4e894b73abad61 171 ProDom PD968187 BETA-DEFENSIN ANTIBIOTIC PRECURSOR ANTIMICROBIAL DEFENSIN BETA SIGNAL DEFENSIN BD-32 DEFB-32 2 166 6.0E-8 T 13-10-2018 TOPB45_1620 e8a434eb1bef08e04866ef47fd8d800d 463 SUPERFAMILY SSF48557 11 461 1.35E-137 T 13-10-2018 IPR008948 L-Aspartase-like GO:0003824 TOPB45_1620 e8a434eb1bef08e04866ef47fd8d800d 463 Gene3D G3DSA:1.10.275.10 30 234 3.4E-180 T 13-10-2018 IPR024083 Fumarase/histidase, N-terminal TOPB45_1620 e8a434eb1bef08e04866ef47fd8d800d 463 PRINTS PR00149 Fumarate lyase superfamily signature 107 125 7.1E-26 T 13-10-2018 IPR000362 Fumarate lyase family TOPB45_1620 e8a434eb1bef08e04866ef47fd8d800d 463 PRINTS PR00149 Fumarate lyase superfamily signature 236 263 7.1E-26 T 13-10-2018 IPR000362 Fumarate lyase family TOPB45_1620 e8a434eb1bef08e04866ef47fd8d800d 463 PRINTS PR00149 Fumarate lyase superfamily signature 152 170 7.1E-26 T 13-10-2018 IPR000362 Fumarate lyase family TOPB45_1620 e8a434eb1bef08e04866ef47fd8d800d 463 PRINTS PR00149 Fumarate lyase superfamily signature 280 296 7.1E-26 T 13-10-2018 IPR000362 Fumarate lyase family TOPB45_1620 e8a434eb1bef08e04866ef47fd8d800d 463 Pfam PF14698 Argininosuccinate lyase C-terminal 368 434 5.5E-24 T 13-10-2018 IPR029419 Argininosuccinate lyase, C-terminal KEGG: 00220+4.3.2.1|KEGG: 00250+4.3.2.1|MetaCyc: PWY-4983|MetaCyc: PWY-4984|MetaCyc: PWY-5|MetaCyc: PWY-5154|MetaCyc: PWY-7400|Reactome: R-HSA-70635 TOPB45_1620 e8a434eb1bef08e04866ef47fd8d800d 463 ProSitePatterns PS00163 Fumarate lyases signature. 280 289 - T 13-10-2018 IPR020557 Fumarate lyase, conserved site GO:0003824 TOPB45_1620 e8a434eb1bef08e04866ef47fd8d800d 463 TIGRFAM TIGR00838 argH: argininosuccinate lyase 9 460 1.9E-183 T 13-10-2018 IPR009049 Argininosuccinate lyase GO:0004056|GO:0042450 KEGG: 00220+4.3.2.1|KEGG: 00250+4.3.2.1|MetaCyc: PWY-4983|MetaCyc: PWY-4984|MetaCyc: PWY-5|MetaCyc: PWY-5154|MetaCyc: PWY-7400|Reactome: R-HSA-70635 TOPB45_1620 e8a434eb1bef08e04866ef47fd8d800d 463 Gene3D G3DSA:1.20.200.10 124 452 3.4E-180 T 13-10-2018 TOPB45_1620 e8a434eb1bef08e04866ef47fd8d800d 463 Pfam PF00206 Lyase 11 305 1.9E-80 T 13-10-2018 IPR022761 Fumarate lyase, N-terminal TOPB45_1620 e8a434eb1bef08e04866ef47fd8d800d 463 PRINTS PR00145 Argininosuccinate lyase family signature 280 296 4.1E-57 T 13-10-2018 TOPB45_1620 e8a434eb1bef08e04866ef47fd8d800d 463 PRINTS PR00145 Argininosuccinate lyase family signature 106 128 4.1E-57 T 13-10-2018 TOPB45_1620 e8a434eb1bef08e04866ef47fd8d800d 463 PRINTS PR00145 Argininosuccinate lyase family signature 315 334 4.1E-57 T 13-10-2018 TOPB45_1620 e8a434eb1bef08e04866ef47fd8d800d 463 PRINTS PR00145 Argininosuccinate lyase family signature 198 214 4.1E-57 T 13-10-2018 TOPB45_1620 e8a434eb1bef08e04866ef47fd8d800d 463 PRINTS PR00145 Argininosuccinate lyase family signature 236 260 4.1E-57 T 13-10-2018 TOPB45_1620 e8a434eb1bef08e04866ef47fd8d800d 463 PRINTS PR00145 Argininosuccinate lyase family signature 147 167 4.1E-57 T 13-10-2018 TOPB45_1620 e8a434eb1bef08e04866ef47fd8d800d 463 Hamap MF_00006 Argininosuccinate lyase [argH]. 7 458 39.757 T 13-10-2018 IPR009049 Argininosuccinate lyase GO:0004056|GO:0042450 KEGG: 00220+4.3.2.1|KEGG: 00250+4.3.2.1|MetaCyc: PWY-4983|MetaCyc: PWY-4984|MetaCyc: PWY-5|MetaCyc: PWY-5154|MetaCyc: PWY-7400|Reactome: R-HSA-70635 TOPB45_1620 e8a434eb1bef08e04866ef47fd8d800d 463 Gene3D G3DSA:1.10.40.30 365 437 3.4E-180 T 13-10-2018 TOPB45_0056 356ba3946f5bb220325c6a180b447e2e 441 Pfam PF00158 Sigma-54 interaction domain 128 293 1.2E-66 T 13-10-2018 IPR002078 RNA polymerase sigma factor 54 interaction domain GO:0005524|GO:0006355|GO:0008134 TOPB45_0056 356ba3946f5bb220325c6a180b447e2e 441 SUPERFAMILY SSF46689 341 435 4.78E-16 T 13-10-2018 IPR009057 Homeobox-like domain superfamily GO:0003677 TOPB45_0056 356ba3946f5bb220325c6a180b447e2e 441 ProSitePatterns PS00688 Sigma-54 interaction domain C-terminal part signature. 340 349 - T 13-10-2018 IPR025944 Sigma-54 interaction domain, conserved site TOPB45_0056 356ba3946f5bb220325c6a180b447e2e 441 ProSitePatterns PS00676 Sigma-54 interaction domain ATP-binding region B signature. 213 228 - T 13-10-2018 IPR025943 Sigma-54 interaction domain, ATP-binding site 2 TOPB45_0056 356ba3946f5bb220325c6a180b447e2e 441 SUPERFAMILY SSF52540 128 369 1.77E-69 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0056 356ba3946f5bb220325c6a180b447e2e 441 SMART SM00382 147 290 7.5E-11 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_0056 356ba3946f5bb220325c6a180b447e2e 441 Gene3D G3DSA:1.10.8.60 300 369 5.3E-26 T 13-10-2018 TOPB45_0056 356ba3946f5bb220325c6a180b447e2e 441 Gene3D G3DSA:3.40.50.300 113 298 1.0E-66 T 13-10-2018 TOPB45_0056 356ba3946f5bb220325c6a180b447e2e 441 Gene3D G3DSA:1.10.10.60 373 438 4.1E-16 T 13-10-2018 TOPB45_0056 356ba3946f5bb220325c6a180b447e2e 441 PRINTS PR01590 FIS bacterial regulatory protein HTH signature 401 418 9.9E-11 T 13-10-2018 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 TOPB45_0056 356ba3946f5bb220325c6a180b447e2e 441 PRINTS PR01590 FIS bacterial regulatory protein HTH signature 418 438 9.9E-11 T 13-10-2018 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 TOPB45_0056 356ba3946f5bb220325c6a180b447e2e 441 Pfam PF02954 Bacterial regulatory protein, Fis family 395 435 7.9E-16 T 13-10-2018 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 TOPB45_0056 356ba3946f5bb220325c6a180b447e2e 441 ProSitePatterns PS00675 Sigma-54 interaction domain ATP-binding region A signature. 151 164 - T 13-10-2018 IPR025662 Sigma-54 interaction domain, ATP-binding site 1 TOPB45_1195 bd77a1877de3cdb304f7efa8dfc5f5f4 537 SMART SM00052 298 532 5.0E-61 T 13-10-2018 IPR001633 EAL domain TOPB45_1195 bd77a1877de3cdb304f7efa8dfc5f5f4 537 SUPERFAMILY SSF141868 305 534 3.01E-63 T 13-10-2018 IPR035919 EAL domain superfamily TOPB45_1195 bd77a1877de3cdb304f7efa8dfc5f5f4 537 SUPERFAMILY SSF55785 14 113 9.07E-12 T 13-10-2018 IPR035965 PAS domain superfamily TOPB45_1195 bd77a1877de3cdb304f7efa8dfc5f5f4 537 SMART SM00267 120 288 2.9E-11 T 13-10-2018 IPR000160 GGDEF domain TOPB45_1195 bd77a1877de3cdb304f7efa8dfc5f5f4 537 Pfam PF13426 PAS domain 25 111 4.6E-11 T 13-10-2018 IPR000014 PAS domain TOPB45_1195 bd77a1877de3cdb304f7efa8dfc5f5f4 537 Gene3D G3DSA:3.30.450.20 12 118 1.1E-11 T 13-10-2018 TOPB45_1195 bd77a1877de3cdb304f7efa8dfc5f5f4 537 Gene3D G3DSA:3.20.20.450 300 536 3.3E-68 T 13-10-2018 IPR035919 EAL domain superfamily TOPB45_1195 bd77a1877de3cdb304f7efa8dfc5f5f4 537 SUPERFAMILY SSF55073 137 290 7.22E-28 T 13-10-2018 IPR029787 Nucleotide cyclase TOPB45_1195 bd77a1877de3cdb304f7efa8dfc5f5f4 537 Gene3D G3DSA:3.30.70.270 126 299 5.7E-31 T 13-10-2018 TOPB45_1195 bd77a1877de3cdb304f7efa8dfc5f5f4 537 TIGRFAM TIGR00254 GGDEF: diguanylate cyclase (GGDEF) domain 134 287 3.2E-16 T 13-10-2018 IPR000160 GGDEF domain TOPB45_1195 bd77a1877de3cdb304f7efa8dfc5f5f4 537 Pfam PF00990 Diguanylate cyclase, GGDEF domain 133 283 2.4E-24 T 13-10-2018 IPR000160 GGDEF domain TOPB45_1195 bd77a1877de3cdb304f7efa8dfc5f5f4 537 Pfam PF00563 EAL domain 305 527 4.7E-56 T 13-10-2018 IPR001633 EAL domain TOPB45_1195 bd77a1877de3cdb304f7efa8dfc5f5f4 537 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 19 113 1.7E-8 T 13-10-2018 IPR000014 PAS domain TOPB45_1195 bd77a1877de3cdb304f7efa8dfc5f5f4 537 SMART SM00091 14 80 2.1E-5 T 13-10-2018 IPR000014 PAS domain TOPB45_0756 554431924b1dfb3ec25823f1e6cd1706 273 SUPERFAMILY SSF50249 3 125 2.19E-53 T 13-10-2018 IPR012340 Nucleic acid-binding, OB-fold TOPB45_0756 554431924b1dfb3ec25823f1e6cd1706 273 Pfam PF03947 Ribosomal Proteins L2, C-terminal domain 125 250 5.0E-59 T 13-10-2018 IPR022669 Ribosomal protein L2, C-terminal GO:0003735|GO:0005840|GO:0006412 TOPB45_0756 554431924b1dfb3ec25823f1e6cd1706 273 SMART SM01382 124 252 9.9E-96 T 13-10-2018 IPR022669 Ribosomal protein L2, C-terminal GO:0003735|GO:0005840|GO:0006412 TOPB45_0756 554431924b1dfb3ec25823f1e6cd1706 273 Hamap MF_01320_B 50S ribosomal protein L2 [rplB]. 1 273 49.06 T 13-10-2018 IPR005880 Ribosomal protein L2, bacterial/organellar-type GO:0003723|GO:0003735|GO:0006412|GO:0015934|GO:0016740 TOPB45_0756 554431924b1dfb3ec25823f1e6cd1706 273 Gene3D G3DSA:4.10.950.10 197 273 7.7E-37 T 13-10-2018 IPR014726 Ribosomal protein L2, domain 3 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0756 554431924b1dfb3ec25823f1e6cd1706 273 TIGRFAM TIGR01171 rplB_bact: ribosomal protein uL2 3 273 3.8E-138 T 13-10-2018 IPR005880 Ribosomal protein L2, bacterial/organellar-type GO:0003723|GO:0003735|GO:0006412|GO:0015934|GO:0016740 TOPB45_0756 554431924b1dfb3ec25823f1e6cd1706 273 Gene3D G3DSA:2.40.50.140 1 114 5.7E-50 T 13-10-2018 TOPB45_0756 554431924b1dfb3ec25823f1e6cd1706 273 Pfam PF00181 Ribosomal Proteins L2, RNA binding domain 42 118 8.5E-34 T 13-10-2018 IPR022666 Ribosomal Proteins L2, RNA binding domain GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0756 554431924b1dfb3ec25823f1e6cd1706 273 SMART SM01383 42 118 1.2E-49 T 13-10-2018 IPR002171 Ribosomal protein L2 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0756 554431924b1dfb3ec25823f1e6cd1706 273 PIRSF PIRSF002158 4 273 2.9E-106 T 13-10-2018 IPR002171 Ribosomal protein L2 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0756 554431924b1dfb3ec25823f1e6cd1706 273 SUPERFAMILY SSF50104 126 272 4.33E-64 T 13-10-2018 IPR008991 Translation protein SH3-like domain superfamily TOPB45_0756 554431924b1dfb3ec25823f1e6cd1706 273 ProSitePatterns PS00467 Ribosomal protein L2 signature. 218 229 - T 13-10-2018 IPR022671 Ribosomal protein L2, conserved site GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0756 554431924b1dfb3ec25823f1e6cd1706 273 Gene3D G3DSA:2.30.30.30 118 196 9.9E-36 T 13-10-2018 IPR014722 Ribosomal protein L2, domain 2 TOPB45_1619 243cb45050faba44a7c7928238802fc7 312 Gene3D G3DSA:3.40.50.620 9 159 2.7E-20 T 13-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TOPB45_1619 243cb45050faba44a7c7928238802fc7 312 Pfam PF00582 Universal stress protein family 10 159 1.3E-14 T 13-10-2018 IPR006016 UspA TOPB45_1619 243cb45050faba44a7c7928238802fc7 312 Pfam PF00582 Universal stress protein family 164 300 4.9E-11 T 13-10-2018 IPR006016 UspA TOPB45_1619 243cb45050faba44a7c7928238802fc7 312 SUPERFAMILY SSF52402 10 161 8.37E-20 T 13-10-2018 TOPB45_1619 243cb45050faba44a7c7928238802fc7 312 Gene3D G3DSA:3.40.50.620 162 304 1.2E-15 T 13-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TOPB45_1619 243cb45050faba44a7c7928238802fc7 312 SUPERFAMILY SSF52402 165 302 9.21E-14 T 13-10-2018 TOPB45_0434 b0da7b9d3d20b7de869439bec2dbc855 99 Pfam PF02915 Rubrerythrin 21 90 4.9E-8 T 13-10-2018 IPR003251 Rubrerythrin GO:0016491|GO:0046872|GO:0055114 TOPB45_0434 b0da7b9d3d20b7de869439bec2dbc855 99 Gene3D G3DSA:1.20.1260.10 2 72 2.3E-11 T 13-10-2018 IPR012347 Ferritin-like TOPB45_0434 b0da7b9d3d20b7de869439bec2dbc855 99 SUPERFAMILY SSF47240 14 80 1.7E-18 T 13-10-2018 IPR009078 Ferritin-like superfamily TOPB45_0309 3eb40d9d8c27e77c15b6e6135dd0ad54 670 Hamap MF_00204 UvrABC system protein B [uvrB]. 8 665 44.063 T 13-10-2018 IPR004807 UvrABC system, subunit B GO:0003677|GO:0005524|GO:0006289|GO:0009380|GO:0016887 TOPB45_0309 3eb40d9d8c27e77c15b6e6135dd0ad54 670 SUPERFAMILY SSF52540 39 577 5.63E-38 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0309 3eb40d9d8c27e77c15b6e6135dd0ad54 670 Gene3D G3DSA:4.10.860.10 615 670 2.1E-9 T 13-10-2018 TOPB45_0309 3eb40d9d8c27e77c15b6e6135dd0ad54 670 SMART SM00487 14 431 9.4E-33 T 13-10-2018 IPR014001 Helicase superfamily 1/2, ATP-binding domain TOPB45_0309 3eb40d9d8c27e77c15b6e6135dd0ad54 670 Pfam PF04851 Type III restriction enzyme, res subunit 17 90 9.1E-11 T 13-10-2018 IPR006935 Helicase/UvrB, N-terminal GO:0003677|GO:0005524|GO:0016787 TOPB45_0309 3eb40d9d8c27e77c15b6e6135dd0ad54 670 SUPERFAMILY SSF52540 9 420 5.24E-136 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0309 3eb40d9d8c27e77c15b6e6135dd0ad54 670 Gene3D G3DSA:3.40.50.300 420 601 1.4E-51 T 13-10-2018 TOPB45_0309 3eb40d9d8c27e77c15b6e6135dd0ad54 670 Gene3D G3DSA:3.40.50.300 275 419 4.2E-57 T 13-10-2018 TOPB45_0309 3eb40d9d8c27e77c15b6e6135dd0ad54 670 Pfam PF12344 Ultra-violet resistance protein B 557 598 7.9E-20 T 13-10-2018 IPR024759 UvrB, YAD/RRR-motif-containing domain TOPB45_0309 3eb40d9d8c27e77c15b6e6135dd0ad54 670 TIGRFAM TIGR00631 uvrb: excinuclease ABC subunit B 9 663 0.0 T 13-10-2018 IPR004807 UvrABC system, subunit B GO:0003677|GO:0005524|GO:0006289|GO:0009380|GO:0016887 TOPB45_0309 3eb40d9d8c27e77c15b6e6135dd0ad54 670 SUPERFAMILY SSF46600 629 667 5.62E-10 T 13-10-2018 IPR036876 UVR domain superfamily TOPB45_0309 3eb40d9d8c27e77c15b6e6135dd0ad54 670 SMART SM00490 465 551 3.8E-21 T 13-10-2018 IPR001650 Helicase, C-terminal TOPB45_0309 3eb40d9d8c27e77c15b6e6135dd0ad54 670 Pfam PF02151 UvrB/uvrC motif 631 664 1.2E-7 T 13-10-2018 IPR001943 UVR domain GO:0005515 TOPB45_0309 3eb40d9d8c27e77c15b6e6135dd0ad54 670 Pfam PF00271 Helicase conserved C-terminal domain 446 549 1.5E-17 T 13-10-2018 IPR001650 Helicase, C-terminal TOPB45_0309 3eb40d9d8c27e77c15b6e6135dd0ad54 670 Gene3D G3DSA:3.40.50.300 1 238 8.2E-78 T 13-10-2018 TOPB45_1075 5d4907a3ff47d914b813eb464145eb97 317 TIGRFAM TIGR00431 TruB: tRNA pseudouridine(55) synthase 9 217 1.0E-73 T 13-10-2018 IPR014780 tRNA pseudouridine synthase II, TruB GO:0001522|GO:0003723|GO:0009451|GO:0009982 TOPB45_1075 5d4907a3ff47d914b813eb464145eb97 317 Pfam PF01509 TruB family pseudouridylate synthase (N terminal domain) 30 178 4.0E-53 T 13-10-2018 IPR002501 Pseudouridine synthase II, N-terminal GO:0006396 TOPB45_1075 5d4907a3ff47d914b813eb464145eb97 317 Pfam PF16198 tRNA pseudouridylate synthase B C-terminal domain 179 239 1.0E-14 T 13-10-2018 IPR032819 tRNA pseudouridylate synthase B, C-terminal Reactome: R-HSA-171319|Reactome: R-HSA-6790901 TOPB45_1075 5d4907a3ff47d914b813eb464145eb97 317 Hamap MF_01080 tRNA pseudouridine synthase B [truB]. 8 315 18.158 T 13-10-2018 IPR014780 tRNA pseudouridine synthase II, TruB GO:0001522|GO:0003723|GO:0009451|GO:0009982 TOPB45_1075 5d4907a3ff47d914b813eb464145eb97 317 Gene3D G3DSA:3.30.2350.10 1 239 1.7E-86 T 13-10-2018 TOPB45_1075 5d4907a3ff47d914b813eb464145eb97 317 SUPERFAMILY SSF55120 8 228 1.9E-76 T 13-10-2018 IPR020103 Pseudouridine synthase, catalytic domain superfamily GO:0001522|GO:0003723|GO:0009451|GO:0009982 TOPB45_0792 6cd8c6459d21250792e7970a3706f3af 698 PRINTS PR00344 Bacterial sensor protein C-terminal signature 653 671 5.9E-6 T 13-10-2018 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TOPB45_0792 6cd8c6459d21250792e7970a3706f3af 698 PRINTS PR00344 Bacterial sensor protein C-terminal signature 677 690 5.9E-6 T 13-10-2018 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TOPB45_0792 6cd8c6459d21250792e7970a3706f3af 698 PRINTS PR00344 Bacterial sensor protein C-terminal signature 625 639 5.9E-6 T 13-10-2018 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TOPB45_0792 6cd8c6459d21250792e7970a3706f3af 698 SMART SM00304 304 359 0.0068 T 13-10-2018 IPR003660 HAMP domain GO:0007165|GO:0016021 TOPB45_0792 6cd8c6459d21250792e7970a3706f3af 698 Gene3D G3DSA:3.30.565.10 543 692 1.3E-23 T 13-10-2018 IPR036890 Histidine kinase/HSP90-like ATPase superfamily TOPB45_0792 6cd8c6459d21250792e7970a3706f3af 698 SMART SM00388 477 549 0.0099 T 13-10-2018 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TOPB45_0792 6cd8c6459d21250792e7970a3706f3af 698 Gene3D G3DSA:3.30.450.20 347 448 2.3E-6 T 13-10-2018 TOPB45_0792 6cd8c6459d21250792e7970a3706f3af 698 SUPERFAMILY SSF55874 543 691 1.63E-24 T 13-10-2018 IPR036890 Histidine kinase/HSP90-like ATPase superfamily TOPB45_0792 6cd8c6459d21250792e7970a3706f3af 698 SUPERFAMILY SSF55785 352 433 5.23E-6 T 13-10-2018 IPR035965 PAS domain superfamily TOPB45_0792 6cd8c6459d21250792e7970a3706f3af 698 PIRSF PIRSF037532 7 696 5.5E-92 T 13-10-2018 IPR017232 Signal transduction histidine kinase, nitrogen fixation and metabolism regulator TOPB45_0792 6cd8c6459d21250792e7970a3706f3af 698 SMART SM00387 588 693 9.6E-17 T 13-10-2018 IPR003594 Histidine kinase/HSP90-like ATPase TOPB45_0792 6cd8c6459d21250792e7970a3706f3af 698 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 592 690 1.0E-13 T 13-10-2018 IPR003594 Histidine kinase/HSP90-like ATPase TOPB45_0792 6cd8c6459d21250792e7970a3706f3af 698 SUPERFAMILY SSF47384 469 546 3.34E-8 T 13-10-2018 IPR036097 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily GO:0000155|GO:0007165 TOPB45_0792 6cd8c6459d21250792e7970a3706f3af 698 Gene3D G3DSA:1.10.287.130 463 542 3.6E-9 T 13-10-2018 TOPB45_0023 6a505b427dbc76a1c5028eb89c1bf157 526 Pfam PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 3 312 2.9E-41 T 13-10-2018 IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain GO:0016616|GO:0051287|GO:0055114 TOPB45_0023 6a505b427dbc76a1c5028eb89c1bf157 526 Gene3D G3DSA:3.40.50.720 92 282 2.0E-129 T 13-10-2018 TOPB45_0023 6a505b427dbc76a1c5028eb89c1bf157 526 ProSitePatterns PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 142 169 - T 13-10-2018 IPR029752 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 TOPB45_0023 6a505b427dbc76a1c5028eb89c1bf157 526 ProSitePatterns PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 219 235 - T 13-10-2018 IPR029753 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site TOPB45_0023 6a505b427dbc76a1c5028eb89c1bf157 526 SUPERFAMILY SSF143548 318 447 3.66E-38 T 13-10-2018 IPR029009 Allosteric substrate binding domain superfamily Reactome: R-HSA-977347 TOPB45_0023 6a505b427dbc76a1c5028eb89c1bf157 526 SUPERFAMILY SSF55021 442 523 5.64E-17 T 13-10-2018 TOPB45_0023 6a505b427dbc76a1c5028eb89c1bf157 526 Pfam PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 105 280 8.0E-67 T 13-10-2018 IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain GO:0051287|GO:0055114 TOPB45_0023 6a505b427dbc76a1c5028eb89c1bf157 526 TIGRFAM TIGR01327 PGDH: phosphoglycerate dehydrogenase 2 525 1.0E-205 T 13-10-2018 IPR006236 D-3-phosphoglycerate dehydrogenase GO:0004617|GO:0006564 KEGG: 00260+1.1.1.95|KEGG: 00680+1.1.1.95|Reactome: R-HSA-977347 TOPB45_0023 6a505b427dbc76a1c5028eb89c1bf157 526 Gene3D G3DSA:3.40.50.720 3 291 2.0E-129 T 13-10-2018 TOPB45_0023 6a505b427dbc76a1c5028eb89c1bf157 526 ProDom PD002844 SMALL SUBUNIT ACETOLACTATE SYNTHASE SYNTHASE TRANSFERASE ACID BIOSYNTHESIS III LYASE 450 526 0.004 T 13-10-2018 TOPB45_0023 6a505b427dbc76a1c5028eb89c1bf157 526 SUPERFAMILY SSF52283 1 133 2.46E-40 T 13-10-2018 TOPB45_0023 6a505b427dbc76a1c5028eb89c1bf157 526 SUPERFAMILY SSF51735 99 281 2.4E-63 T 13-10-2018 IPR036291 NAD(P)-binding domain superfamily TOPB45_0023 6a505b427dbc76a1c5028eb89c1bf157 526 Gene3D G3DSA:3.30.1330.90 318 452 3.3E-43 T 13-10-2018 IPR029009 Allosteric substrate binding domain superfamily Reactome: R-HSA-977347 TOPB45_0023 6a505b427dbc76a1c5028eb89c1bf157 526 Gene3D G3DSA:3.30.70.260 453 526 2.8E-18 T 13-10-2018 TOPB45_0023 6a505b427dbc76a1c5028eb89c1bf157 526 Pfam PF01842 ACT domain 453 515 2.4E-8 T 13-10-2018 IPR002912 ACT domain TOPB45_0023 6a505b427dbc76a1c5028eb89c1bf157 526 ProSitePatterns PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. 190 212 - T 13-10-2018 IPR029753 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site TOPB45_1500 09ee5c9a7664ccbbe5c3d35cd9a203c2 214 SMART SM00849 12 191 1.6E-41 T 13-10-2018 IPR001279 Metallo-beta-lactamase TOPB45_1500 09ee5c9a7664ccbbe5c3d35cd9a203c2 214 Gene3D G3DSA:3.60.15.10 1 214 1.5E-70 T 13-10-2018 IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like TOPB45_1500 09ee5c9a7664ccbbe5c3d35cd9a203c2 214 SUPERFAMILY SSF56281 1 212 4.98E-57 T 13-10-2018 IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like TOPB45_1500 09ee5c9a7664ccbbe5c3d35cd9a203c2 214 Pfam PF00753 Metallo-beta-lactamase superfamily 10 191 1.2E-28 T 13-10-2018 IPR001279 Metallo-beta-lactamase TOPB45_0463 fd4905bc70b9c078d49293d84bdd0ccd 238 Pfam PF02492 CobW/HypB/UreG, nucleotide-binding domain 46 207 2.8E-30 T 13-10-2018 IPR003495 CobW/HypB/UreG, nucleotide-binding domain TOPB45_0463 fd4905bc70b9c078d49293d84bdd0ccd 238 PIRSF PIRSF005624 10 237 1.8E-93 T 13-10-2018 IPR012202 [NiFe]-hydrogenase/urease maturation factor, Ni2-binding GTPase GO:0003924|GO:0016151 TOPB45_0463 fd4905bc70b9c078d49293d84bdd0ccd 238 TIGRFAM TIGR00073 hypB: hydrogenase accessory protein HypB 19 228 1.2E-91 T 13-10-2018 IPR004392 Hydrogenase maturation factor HypB GO:0016151|GO:0051604 TOPB45_0463 fd4905bc70b9c078d49293d84bdd0ccd 238 Gene3D G3DSA:3.40.50.300 27 236 9.4E-66 T 13-10-2018 TOPB45_0463 fd4905bc70b9c078d49293d84bdd0ccd 238 SUPERFAMILY SSF52540 16 233 8.2E-38 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0222 616c7334a3926c9c32b24f095c90e6a8 261 Pfam PF13614 AAA domain 1 179 1.0E-52 T 13-10-2018 IPR025669 AAA domain TOPB45_0222 616c7334a3926c9c32b24f095c90e6a8 261 Gene3D G3DSA:3.40.50.300 1 261 6.2E-76 T 13-10-2018 TOPB45_0222 616c7334a3926c9c32b24f095c90e6a8 261 SUPERFAMILY SSF52540 1 257 8.09E-59 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0518 943ed17819dc5f53b99323eab01a0731 190 PIRSF PIRSF000847 6 190 4.3E-37 T 13-10-2018 IPR004570 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase GO:0008444|GO:0008654|GO:0016021 KEGG: 00564+2.7.8.5|MetaCyc: PWY-5269|MetaCyc: PWY-5668|MetaCyc: PWY-7817 TOPB45_0518 943ed17819dc5f53b99323eab01a0731 190 ProSitePatterns PS00379 CDP-alcohol phosphatidyltransferases signature. 53 75 - T 13-10-2018 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 TOPB45_0518 943ed17819dc5f53b99323eab01a0731 190 Pfam PF01066 CDP-alcohol phosphatidyltransferase 11 75 1.2E-13 T 13-10-2018 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 TOPB45_0518 943ed17819dc5f53b99323eab01a0731 190 Gene3D G3DSA:1.20.120.1760 8 177 4.0E-8 T 13-10-2018 TOPB45_0719 59bf291fac98f1fcd4637886ee293379 194 SUPERFAMILY SSF54211 90 180 2.02E-34 T 13-10-2018 IPR020568 Ribosomal protein S5 domain 2-type fold TOPB45_0719 59bf291fac98f1fcd4637886ee293379 194 ProSitePatterns PS00954 Imidazoleglycerol-phosphate dehydratase signature 1. 63 76 - T 13-10-2018 IPR020565 Imidazoleglycerol-phosphate dehydratase, conserved site GO:0000105|GO:0004424 KEGG: 00340+4.2.1.19 TOPB45_0719 59bf291fac98f1fcd4637886ee293379 194 SUPERFAMILY SSF54211 5 88 5.31E-28 T 13-10-2018 IPR020568 Ribosomal protein S5 domain 2-type fold TOPB45_0719 59bf291fac98f1fcd4637886ee293379 194 Gene3D G3DSA:3.30.230.40 92 194 6.2E-36 T 13-10-2018 IPR038494 Imidazole glycerol phosphate dehydratase domain superfamily KEGG: 00340+4.2.1.19 TOPB45_0719 59bf291fac98f1fcd4637886ee293379 194 Gene3D G3DSA:3.30.230.40 2 91 1.2E-31 T 13-10-2018 IPR038494 Imidazole glycerol phosphate dehydratase domain superfamily KEGG: 00340+4.2.1.19 TOPB45_0719 59bf291fac98f1fcd4637886ee293379 194 Hamap MF_00076 Imidazoleglycerol-phosphate dehydratase [hisB]. 2 194 38.249 T 13-10-2018 IPR000807 Imidazoleglycerol-phosphate dehydratase GO:0000105|GO:0004424 KEGG: 00340+4.2.1.19 TOPB45_0719 59bf291fac98f1fcd4637886ee293379 194 ProSitePatterns PS00955 Imidazoleglycerol-phosphate dehydratase signature 2. 158 170 - T 13-10-2018 IPR020565 Imidazoleglycerol-phosphate dehydratase, conserved site GO:0000105|GO:0004424 KEGG: 00340+4.2.1.19 TOPB45_0719 59bf291fac98f1fcd4637886ee293379 194 Pfam PF00475 Imidazoleglycerol-phosphate dehydratase 33 176 4.3E-62 T 13-10-2018 IPR000807 Imidazoleglycerol-phosphate dehydratase GO:0000105|GO:0004424 KEGG: 00340+4.2.1.19 TOPB45_0486 84ab9e2983f50776b7477fa29392f69a 401 ProSitePatterns PS00565 Argininosuccinate synthase signature 2. 117 128 - T 13-10-2018 IPR018223 Argininosuccinate synthase, conserved site GO:0004055|GO:0005524|GO:0006526 KEGG: 00220+6.3.4.5|KEGG: 00250+6.3.4.5|MetaCyc: PWY-4983|MetaCyc: PWY-4984|MetaCyc: PWY-5|MetaCyc: PWY-5154|MetaCyc: PWY-7400|Reactome: R-HSA-70635 TOPB45_0486 84ab9e2983f50776b7477fa29392f69a 401 Gene3D G3DSA:3.90.1260.10 175 399 1.7E-107 T 13-10-2018 IPR024074 Argininosuccinate synthetase, catalytic/multimerisation domain body GO:0004055 KEGG: 00220+6.3.4.5|KEGG: 00250+6.3.4.5|MetaCyc: PWY-4983|MetaCyc: PWY-4984|MetaCyc: PWY-5|MetaCyc: PWY-5154|MetaCyc: PWY-7400|Reactome: R-HSA-70635 TOPB45_0486 84ab9e2983f50776b7477fa29392f69a 401 Pfam PF00764 Arginosuccinate synthase 7 394 5.7E-171 T 13-10-2018 IPR001518 Argininosuccinate synthase GO:0004055|GO:0005524|GO:0006526 KEGG: 00220+6.3.4.5|KEGG: 00250+6.3.4.5|MetaCyc: PWY-4983|MetaCyc: PWY-4984|MetaCyc: PWY-5|MetaCyc: PWY-5154|MetaCyc: PWY-7400|Reactome: R-HSA-70635 TOPB45_0486 84ab9e2983f50776b7477fa29392f69a 401 ProSitePatterns PS00564 Argininosuccinate synthase signature 1. 9 17 - T 13-10-2018 IPR018223 Argininosuccinate synthase, conserved site GO:0004055|GO:0005524|GO:0006526 KEGG: 00220+6.3.4.5|KEGG: 00250+6.3.4.5|MetaCyc: PWY-4983|MetaCyc: PWY-4984|MetaCyc: PWY-5|MetaCyc: PWY-5154|MetaCyc: PWY-7400|Reactome: R-HSA-70635 TOPB45_0486 84ab9e2983f50776b7477fa29392f69a 401 Hamap MF_00005 Argininosuccinate synthase [argG]. 3 398 53.485 T 13-10-2018 IPR023434 Argininosuccinate synthase, type 1 subfamily GO:0004055 KEGG: 00220+6.3.4.5|KEGG: 00250+6.3.4.5|MetaCyc: PWY-4983|MetaCyc: PWY-4984|MetaCyc: PWY-5|MetaCyc: PWY-5154|MetaCyc: PWY-7400|Reactome: R-HSA-70635 TOPB45_0486 84ab9e2983f50776b7477fa29392f69a 401 SUPERFAMILY SSF52402 4 167 3.31E-48 T 13-10-2018 TOPB45_0486 84ab9e2983f50776b7477fa29392f69a 401 Gene3D G3DSA:3.40.50.620 4 174 1.9E-69 T 13-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TOPB45_0486 84ab9e2983f50776b7477fa29392f69a 401 SUPERFAMILY SSF69864 172 396 9.29E-99 T 13-10-2018 TOPB45_0486 84ab9e2983f50776b7477fa29392f69a 401 TIGRFAM TIGR00032 argG: argininosuccinate synthase 5 394 6.7E-161 T 13-10-2018 IPR001518 Argininosuccinate synthase GO:0004055|GO:0005524|GO:0006526 KEGG: 00220+6.3.4.5|KEGG: 00250+6.3.4.5|MetaCyc: PWY-4983|MetaCyc: PWY-4984|MetaCyc: PWY-5|MetaCyc: PWY-5154|MetaCyc: PWY-7400|Reactome: R-HSA-70635 TOPB45_1459 d9b32090df10f8318f60050838f7dd4c 452 Gene3D G3DSA:1.10.1060.10 35 156 2.6E-8 T 13-10-2018 IPR009051 Alpha-helical ferredoxin GO:0051536 TOPB45_1459 d9b32090df10f8318f60050838f7dd4c 452 SUPERFAMILY SSF46548 59 153 1.38E-12 T 13-10-2018 IPR009051 Alpha-helical ferredoxin GO:0051536 TOPB45_1459 d9b32090df10f8318f60050838f7dd4c 452 Pfam PF13183 4Fe-4S dicluster domain 65 139 7.4E-9 T 13-10-2018 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain TOPB45_1459 d9b32090df10f8318f60050838f7dd4c 452 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 125 136 - T 13-10-2018 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site TOPB45_1459 d9b32090df10f8318f60050838f7dd4c 452 Pfam PF02754 Cysteine-rich domain 336 424 1.4E-8 T 13-10-2018 IPR004017 Cysteine-rich domain TOPB45_0851 2b305cb10a2b6a51a1081d9d4443b200 144 TIGRFAM TIGR02805 exbB2: tonB-system energizer ExbB 2 138 5.9E-48 T 13-10-2018 IPR014172 TonB-system energizer ExbB type-2 GO:0016020|GO:0055085 TOPB45_0851 2b305cb10a2b6a51a1081d9d4443b200 144 Pfam PF01618 MotA/TolQ/ExbB proton channel family 47 136 1.2E-28 T 13-10-2018 IPR002898 MotA/TolQ/ExbB proton channel TOPB45_0831 a9b085d8a88664f445cb7a31ebd8632f 226 SUPERFAMILY SSF56300 10 208 6.84E-54 T 13-10-2018 TOPB45_0831 a9b085d8a88664f445cb7a31ebd8632f 226 Pfam PF00149 Calcineurin-like phosphoesterase 14 198 1.8E-21 T 13-10-2018 IPR004843 Calcineurin-like phosphoesterase domain, ApaH type GO:0016787 TOPB45_0831 a9b085d8a88664f445cb7a31ebd8632f 226 Gene3D G3DSA:3.60.21.10 7 225 5.4E-67 T 13-10-2018 IPR029052 Metallo-dependent phosphatase-like TOPB45_0427 dc91ee2e52d5876cc2ca251549847528 865 SUPERFAMILY SSF55271 7 114 3.92E-38 T 13-10-2018 IPR016151 DNA mismatch repair protein MutS, N-terminal GO:0005524|GO:0006298|GO:0030983 Reactome: R-HSA-5632928 TOPB45_0427 dc91ee2e52d5876cc2ca251549847528 865 Gene3D G3DSA:3.30.420.110 128 256 8.1E-16 T 13-10-2018 IPR036678 MutS, connector domain superfamily GO:0005524|GO:0006298|GO:0030983 TOPB45_0427 dc91ee2e52d5876cc2ca251549847528 865 PIRSF PIRSF037677 4 845 1.7E-173 T 13-10-2018 IPR017261 DNA mismatch repair protein MutS/MSH GO:0006298|GO:0030983 TOPB45_0427 dc91ee2e52d5876cc2ca251549847528 865 TIGRFAM TIGR01070 mutS1: DNA mismatch repair protein MutS 10 855 6.1E-301 T 13-10-2018 IPR005748 DNA mismatch repair protein MutS GO:0005524|GO:0006298|GO:0030983 TOPB45_0427 dc91ee2e52d5876cc2ca251549847528 865 Pfam PF05188 MutS domain II 129 242 3.0E-8 T 13-10-2018 IPR007860 DNA mismatch repair protein MutS, connector domain GO:0005524|GO:0006298|GO:0030983 TOPB45_0427 dc91ee2e52d5876cc2ca251549847528 865 Hamap MF_00096 DNA mismatch repair protein MutS [mutS]. 9 849 23.84 T 13-10-2018 IPR005748 DNA mismatch repair protein MutS GO:0005524|GO:0006298|GO:0030983 TOPB45_0427 dc91ee2e52d5876cc2ca251549847528 865 SUPERFAMILY SSF53150 119 277 3.92E-27 T 13-10-2018 IPR036678 MutS, connector domain superfamily GO:0005524|GO:0006298|GO:0030983 TOPB45_0427 dc91ee2e52d5876cc2ca251549847528 865 SUPERFAMILY SSF52540 569 801 1.28E-60 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0427 dc91ee2e52d5876cc2ca251549847528 865 Pfam PF05190 MutS family domain IV 430 520 8.7E-28 T 13-10-2018 IPR007861 DNA mismatch repair protein MutS, clamp GO:0005524|GO:0006298|GO:0030983 TOPB45_0427 dc91ee2e52d5876cc2ca251549847528 865 Pfam PF05192 MutS domain III 266 561 2.3E-47 T 13-10-2018 IPR007696 DNA mismatch repair protein MutS, core GO:0005524|GO:0006298|GO:0030983 TOPB45_0427 dc91ee2e52d5876cc2ca251549847528 865 SMART SM00534 611 797 5.2E-113 T 13-10-2018 IPR000432 DNA mismatch repair protein MutS, C-terminal GO:0005524|GO:0006298|GO:0030983 TOPB45_0427 dc91ee2e52d5876cc2ca251549847528 865 Gene3D G3DSA:1.10.1420.10 402 537 2.9E-101 T 13-10-2018 TOPB45_0427 dc91ee2e52d5876cc2ca251549847528 865 Pfam PF01624 MutS domain I 10 119 1.5E-38 T 13-10-2018 IPR007695 DNA mismatch repair protein MutS-like, N-terminal GO:0005524|GO:0006298|GO:0030983 Reactome: R-HSA-5632928 TOPB45_0427 dc91ee2e52d5876cc2ca251549847528 865 Pfam PF00488 MutS domain V 614 800 9.4E-84 T 13-10-2018 IPR000432 DNA mismatch repair protein MutS, C-terminal GO:0005524|GO:0006298|GO:0030983 TOPB45_0427 dc91ee2e52d5876cc2ca251549847528 865 Gene3D G3DSA:1.10.1420.10 263 561 2.9E-101 T 13-10-2018 TOPB45_0427 dc91ee2e52d5876cc2ca251549847528 865 SMART SM00533 281 593 1.2E-107 T 13-10-2018 IPR007696 DNA mismatch repair protein MutS, core GO:0005524|GO:0006298|GO:0030983 TOPB45_0427 dc91ee2e52d5876cc2ca251549847528 865 ProSitePatterns PS00486 DNA mismatch repair proteins mutS family signature. 692 708 - T 13-10-2018 IPR000432 DNA mismatch repair protein MutS, C-terminal GO:0005524|GO:0006298|GO:0030983 TOPB45_0427 dc91ee2e52d5876cc2ca251549847528 865 Gene3D G3DSA:3.40.1170.10 1 121 3.1E-42 T 13-10-2018 IPR016151 DNA mismatch repair protein MutS, N-terminal GO:0005524|GO:0006298|GO:0030983 Reactome: R-HSA-5632928 TOPB45_0427 dc91ee2e52d5876cc2ca251549847528 865 Gene3D G3DSA:3.40.50.300 571 865 9.8E-105 T 13-10-2018 TOPB45_0427 dc91ee2e52d5876cc2ca251549847528 865 SUPERFAMILY SSF48334 264 567 2.09E-90 T 13-10-2018 IPR036187 DNA mismatch repair protein MutS, core domain superfamily TOPB45_1542 ea743b1fef7a53620bb4244331a2ffaa 791 TIGRFAM TIGR00360 ComEC_N-term: ComEC/Rec2-related protein 229 420 1.9E-16 T 13-10-2018 IPR004477 ComEC/Rec2-related protein TOPB45_1542 ea743b1fef7a53620bb4244331a2ffaa 791 Gene3D G3DSA:3.60.15.10 513 751 3.4E-43 T 13-10-2018 IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like TOPB45_1542 ea743b1fef7a53620bb4244331a2ffaa 791 SMART SM00849 524 690 1.7E-5 T 13-10-2018 IPR001279 Metallo-beta-lactamase TOPB45_1542 ea743b1fef7a53620bb4244331a2ffaa 791 SUPERFAMILY SSF56281 513 752 4.47E-32 T 13-10-2018 IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like TOPB45_1542 ea743b1fef7a53620bb4244331a2ffaa 791 TIGRFAM TIGR00361 ComEC_Rec2: DNA internalization-related competence protein ComEC/Rec2 137 734 1.4E-59 T 13-10-2018 IPR004797 Competence protein ComEC/Rec2 GO:0016021|GO:0030420 TOPB45_1542 ea743b1fef7a53620bb4244331a2ffaa 791 Pfam PF00753 Metallo-beta-lactamase superfamily 525 669 3.7E-9 T 13-10-2018 IPR001279 Metallo-beta-lactamase TOPB45_1542 ea743b1fef7a53620bb4244331a2ffaa 791 Pfam PF03772 Competence protein 206 481 4.5E-37 T 13-10-2018 IPR004477 ComEC/Rec2-related protein TOPB45_0458 a817a386091a4a782d224acf174581ca 224 Pfam PF00072 Response regulator receiver domain 4 113 3.5E-20 T 13-10-2018 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TOPB45_0458 a817a386091a4a782d224acf174581ca 224 Gene3D G3DSA:3.40.50.2300 1 124 4.2E-31 T 13-10-2018 TOPB45_0458 a817a386091a4a782d224acf174581ca 224 SUPERFAMILY SSF52172 2 128 2.42E-32 T 13-10-2018 IPR011006 CheY-like superfamily TOPB45_0458 a817a386091a4a782d224acf174581ca 224 SUPERFAMILY SSF46894 124 221 2.35E-25 T 13-10-2018 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TOPB45_0458 a817a386091a4a782d224acf174581ca 224 SMART SM00448 2 116 3.0E-33 T 13-10-2018 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TOPB45_0458 a817a386091a4a782d224acf174581ca 224 Gene3D G3DSA:1.10.10.10 126 224 3.7E-29 T 13-10-2018 IPR036388 Winged helix-like DNA-binding domain superfamily TOPB45_0458 a817a386091a4a782d224acf174581ca 224 SMART SM00862 148 221 5.7E-23 T 13-10-2018 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TOPB45_0458 a817a386091a4a782d224acf174581ca 224 Pfam PF00486 Transcriptional regulatory protein, C terminal 151 221 2.7E-22 T 13-10-2018 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 TOPB45_1266 127a49971c710721e45d99db2a9597f5 388 Hamap MF_02040 Iron-sulfur cluster carrier protein. 19 270 35.749 T 13-10-2018 IPR019591 Mrp/NBP35 ATP-binding protein TOPB45_1266 127a49971c710721e45d99db2a9597f5 388 ProSitePatterns PS01215 Mrp family signature. 133 149 - T 13-10-2018 IPR000808 Mrp, conserved site GO:0005524 TOPB45_1266 127a49971c710721e45d99db2a9597f5 388 Gene3D G3DSA:3.40.50.300 9 268 4.4E-85 T 13-10-2018 TOPB45_1266 127a49971c710721e45d99db2a9597f5 388 SUPERFAMILY SSF53146 286 384 1.02E-7 T 13-10-2018 IPR036105 Dinitrogenase iron-molybdenum cofactor biosynthesis superfamily TOPB45_1266 127a49971c710721e45d99db2a9597f5 388 Gene3D G3DSA:3.30.420.130 283 387 5.2E-9 T 13-10-2018 IPR036105 Dinitrogenase iron-molybdenum cofactor biosynthesis superfamily TOPB45_1266 127a49971c710721e45d99db2a9597f5 388 Pfam PF10609 NUBPL iron-transfer P-loop NTPase 23 269 1.4E-95 T 13-10-2018 IPR033756 Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35 TOPB45_1266 127a49971c710721e45d99db2a9597f5 388 SUPERFAMILY SSF52540 13 254 3.69E-55 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1286 c3c9d18bfb82e67d03197a724b82909b 789 Gene3D G3DSA:3.30.230.10 533 772 3.3E-97 T 13-10-2018 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup TOPB45_1286 c3c9d18bfb82e67d03197a724b82909b 789 SUPERFAMILY SSF54211 556 750 1.44E-38 T 13-10-2018 IPR020568 Ribosomal protein S5 domain 2-type fold TOPB45_1286 c3c9d18bfb82e67d03197a724b82909b 789 Pfam PF13654 AAA domain 21 532 3.6E-150 T 13-10-2018 TOPB45_1286 c3c9d18bfb82e67d03197a724b82909b 789 Pfam PF05362 Lon protease (S16) C-terminal proteolytic domain 640 746 1.0E-11 T 13-10-2018 IPR008269 Peptidase S16, Lon proteolytic domain GO:0004176|GO:0004252|GO:0006508 TOPB45_1286 c3c9d18bfb82e67d03197a724b82909b 789 Gene3D G3DSA:3.40.50.300 228 447 3.3E-47 T 13-10-2018 TOPB45_1286 c3c9d18bfb82e67d03197a724b82909b 789 Gene3D G3DSA:3.40.50.300 6 172 9.6E-21 T 13-10-2018 TOPB45_1286 c3c9d18bfb82e67d03197a724b82909b 789 PRINTS PR00830 Endopeptidase La (Lon) serine protease (S16) signature 57 76 8.5E-12 T 13-10-2018 TOPB45_1286 c3c9d18bfb82e67d03197a724b82909b 789 PRINTS PR00830 Endopeptidase La (Lon) serine protease (S16) signature 639 658 8.5E-12 T 13-10-2018 TOPB45_1286 c3c9d18bfb82e67d03197a724b82909b 789 PRINTS PR00830 Endopeptidase La (Lon) serine protease (S16) signature 669 688 8.5E-12 T 13-10-2018 TOPB45_1286 c3c9d18bfb82e67d03197a724b82909b 789 PRINTS PR00830 Endopeptidase La (Lon) serine protease (S16) signature 558 574 8.5E-12 T 13-10-2018 TOPB45_1286 c3c9d18bfb82e67d03197a724b82909b 789 PRINTS PR00830 Endopeptidase La (Lon) serine protease (S16) signature 699 717 8.5E-12 T 13-10-2018 TOPB45_1627 c041ff2295a95b877f0621f423d9fea8 221 SUPERFAMILY SSF50199 28 161 5.1E-28 T 13-10-2018 TOPB45_1627 c041ff2295a95b877f0621f423d9fea8 221 Pfam PF00565 Staphylococcal nuclease homologue 54 159 2.6E-19 T 13-10-2018 IPR016071 Staphylococcal nuclease (SNase-like), OB-fold Reactome: R-HSA-6802952 TOPB45_1627 c041ff2295a95b877f0621f423d9fea8 221 SMART SM00318 32 161 6.8E-25 T 13-10-2018 IPR016071 Staphylococcal nuclease (SNase-like), OB-fold Reactome: R-HSA-6802952 TOPB45_1627 c041ff2295a95b877f0621f423d9fea8 221 Gene3D G3DSA:2.40.50.90 25 165 1.7E-29 T 13-10-2018 IPR035437 SNase-like, OB-fold superfamily TOPB45_1627 c041ff2295a95b877f0621f423d9fea8 221 SUPERFAMILY SSF57884 166 214 2.35E-9 T 13-10-2018 IPR035451 Ada-like domain superfamily TOPB45_0704 3c1ea9d0d08c356abcb97fd5d0f3ccee 1201 Pfam PF13597 Anaerobic ribonucleoside-triphosphate reductase 366 584 4.4E-47 T 13-10-2018 IPR012833 Ribonucleoside-triphosphate reductase, anaerobic GO:0006260|GO:0008998|GO:0016491|GO:0055114 KEGG: 00230+1.1.98.6|KEGG: 00240+1.1.98.6|MetaCyc: PWY-7187|MetaCyc: PWY-7220|MetaCyc: PWY-7222 TOPB45_0704 3c1ea9d0d08c356abcb97fd5d0f3ccee 1201 Pfam PF13597 Anaerobic ribonucleoside-triphosphate reductase 123 224 1.7E-27 T 13-10-2018 IPR012833 Ribonucleoside-triphosphate reductase, anaerobic GO:0006260|GO:0008998|GO:0016491|GO:0055114 KEGG: 00230+1.1.98.6|KEGG: 00240+1.1.98.6|MetaCyc: PWY-7187|MetaCyc: PWY-7220|MetaCyc: PWY-7222 TOPB45_0704 3c1ea9d0d08c356abcb97fd5d0f3ccee 1201 Pfam PF13597 Anaerobic ribonucleoside-triphosphate reductase 886 1176 2.5E-87 T 13-10-2018 IPR012833 Ribonucleoside-triphosphate reductase, anaerobic GO:0006260|GO:0008998|GO:0016491|GO:0055114 KEGG: 00230+1.1.98.6|KEGG: 00240+1.1.98.6|MetaCyc: PWY-7187|MetaCyc: PWY-7220|MetaCyc: PWY-7222 TOPB45_0704 3c1ea9d0d08c356abcb97fd5d0f3ccee 1201 SUPERFAMILY SSF51998 365 558 7.02E-44 T 13-10-2018 TOPB45_0704 3c1ea9d0d08c356abcb97fd5d0f3ccee 1201 SUPERFAMILY SSF51998 124 224 2.62E-23 T 13-10-2018 TOPB45_0704 3c1ea9d0d08c356abcb97fd5d0f3ccee 1201 SUPERFAMILY SSF51294 223 367 1.03E-14 T 13-10-2018 IPR036844 Hint domain superfamily Reactome: R-HSA-373080|Reactome: R-HSA-5358346|Reactome: R-HSA-5362798|Reactome: R-HSA-5632681|Reactome: R-HSA-5632684|Reactome: R-HSA-5635838|Reactome: R-HSA-5658034 TOPB45_0704 3c1ea9d0d08c356abcb97fd5d0f3ccee 1201 SUPERFAMILY SSF51294 526 893 1.51E-19 T 13-10-2018 IPR036844 Hint domain superfamily Reactome: R-HSA-373080|Reactome: R-HSA-5358346|Reactome: R-HSA-5362798|Reactome: R-HSA-5632681|Reactome: R-HSA-5632684|Reactome: R-HSA-5635838|Reactome: R-HSA-5658034 TOPB45_0704 3c1ea9d0d08c356abcb97fd5d0f3ccee 1201 Gene3D G3DSA:2.170.16.10 526 668 1.3E-17 T 13-10-2018 TOPB45_0704 3c1ea9d0d08c356abcb97fd5d0f3ccee 1201 Pfam PF03477 ATP cone domain 5 94 2.4E-20 T 13-10-2018 IPR005144 ATP-cone domain Reactome: R-HSA-499943 TOPB45_0704 3c1ea9d0d08c356abcb97fd5d0f3ccee 1201 Gene3D G3DSA:3.20.70.20 135 224 9.2E-19 T 13-10-2018 TOPB45_0704 3c1ea9d0d08c356abcb97fd5d0f3ccee 1201 Gene3D G3DSA:3.20.70.20 834 1178 2.9E-71 T 13-10-2018 TOPB45_0704 3c1ea9d0d08c356abcb97fd5d0f3ccee 1201 SMART SM00306 221 322 9.9E-5 T 13-10-2018 IPR003587 Hint domain N-terminal Reactome: R-HSA-373080|Reactome: R-HSA-5358346|Reactome: R-HSA-5362798|Reactome: R-HSA-5632681|Reactome: R-HSA-5632684|Reactome: R-HSA-5635838|Reactome: R-HSA-5658034 TOPB45_0704 3c1ea9d0d08c356abcb97fd5d0f3ccee 1201 SMART SM00306 524 645 3.3E-8 T 13-10-2018 IPR003587 Hint domain N-terminal Reactome: R-HSA-373080|Reactome: R-HSA-5358346|Reactome: R-HSA-5362798|Reactome: R-HSA-5632681|Reactome: R-HSA-5632684|Reactome: R-HSA-5635838|Reactome: R-HSA-5658034 TOPB45_0704 3c1ea9d0d08c356abcb97fd5d0f3ccee 1201 Pfam PF14890 Intein splicing domain 567 883 6.3E-18 T 13-10-2018 TOPB45_0704 3c1ea9d0d08c356abcb97fd5d0f3ccee 1201 Gene3D G3DSA:2.170.16.10 225 369 3.2E-9 T 13-10-2018 TOPB45_0704 3c1ea9d0d08c356abcb97fd5d0f3ccee 1201 SUPERFAMILY SSF51998 884 1168 6.1E-76 T 13-10-2018 TOPB45_0704 3c1ea9d0d08c356abcb97fd5d0f3ccee 1201 PRINTS PR00379 Intein signature 282 295 2.9E-6 T 13-10-2018 IPR006142 Intein GO:0016539 TOPB45_0704 3c1ea9d0d08c356abcb97fd5d0f3ccee 1201 PRINTS PR00379 Intein signature 774 786 2.9E-6 T 13-10-2018 IPR006142 Intein GO:0016539 TOPB45_0704 3c1ea9d0d08c356abcb97fd5d0f3ccee 1201 PRINTS PR00379 Intein signature 668 680 2.9E-6 T 13-10-2018 IPR006142 Intein GO:0016539 TOPB45_0704 3c1ea9d0d08c356abcb97fd5d0f3ccee 1201 PRINTS PR00379 Intein signature 868 885 2.9E-6 T 13-10-2018 IPR006142 Intein GO:0016539 TOPB45_0704 3c1ea9d0d08c356abcb97fd5d0f3ccee 1201 Gene3D G3DSA:3.10.28.10 669 833 2.2E-19 T 13-10-2018 IPR027434 Homing endonuclease TOPB45_0704 3c1ea9d0d08c356abcb97fd5d0f3ccee 1201 SUPERFAMILY SSF55608 759 823 9.07E-5 T 13-10-2018 IPR027434 Homing endonuclease TOPB45_1376 aace5752b34518c797e3cabc7ec4864e 185 Gene3D G3DSA:3.40.1280.10 4 183 4.0E-43 T 13-10-2018 IPR029026 tRNA (guanine-N1-)-methyltransferase, N-terminal TOPB45_1376 aace5752b34518c797e3cabc7ec4864e 185 SUPERFAMILY SSF75217 19 170 1.9E-32 T 13-10-2018 IPR029028 Alpha/beta knot methyltransferases TOPB45_1376 aace5752b34518c797e3cabc7ec4864e 185 Pfam PF00588 SpoU rRNA Methylase family 26 167 4.6E-28 T 13-10-2018 IPR001537 tRNA/rRNA methyltransferase, SpoU type GO:0003723|GO:0006396|GO:0008173 TOPB45_0282 581fcb29fdde6447e2119a6070759a9a 650 Pfam PF12439 Glycogen debranching enzyme N terminal 13 231 1.6E-52 T 13-10-2018 IPR024742 Glycogen debranching enzyme, bacterial and archaeal type, N-terminal TOPB45_0282 581fcb29fdde6447e2119a6070759a9a 650 SUPERFAMILY SSF48208 179 638 2.09E-48 T 13-10-2018 IPR008928 Six-hairpin glycosidase superfamily GO:0003824 TOPB45_0282 581fcb29fdde6447e2119a6070759a9a 650 Pfam PF06202 Amylo-alpha-1,6-glucosidase 288 636 1.3E-86 T 13-10-2018 IPR032790 Glycogen debranching enzyme, C-terminal KEGG: 00500+2.4.1.25|MetaCyc: PWY-5941|MetaCyc: PWY-6724|MetaCyc: PWY-6737|MetaCyc: PWY-7238|Reactome: R-HSA-6798695|Reactome: R-HSA-70221 TOPB45_0282 581fcb29fdde6447e2119a6070759a9a 650 Gene3D G3DSA:1.50.10.10 435 641 3.6E-15 T 13-10-2018 IPR012341 Six-hairpin glycosidase-like superfamily GO:0003824 TOPB45_1377 13567b412aa5b5f83f80c026096c1f45 592 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 465 483 7.7E-6 T 13-10-2018 IPR006073 GTP binding domain GO:0005525 TOPB45_1377 13567b412aa5b5f83f80c026096c1f45 592 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 398 418 7.7E-6 T 13-10-2018 IPR006073 GTP binding domain GO:0005525 TOPB45_1377 13567b412aa5b5f83f80c026096c1f45 592 TIGRFAM TIGR03156 GTP_HflX: GTP-binding protein HflX 207 561 3.5E-135 T 13-10-2018 IPR016496 GTPase HflX GO:0005525 TOPB45_1377 13567b412aa5b5f83f80c026096c1f45 592 Pfam PF01926 50S ribosome-binding GTPase 398 516 3.2E-19 T 13-10-2018 IPR006073 GTP binding domain GO:0005525 TOPB45_1377 13567b412aa5b5f83f80c026096c1f45 592 Pfam PF16360 GTP-binding GTPase Middle Region 312 390 1.0E-28 T 13-10-2018 IPR032305 GTP-binding protein, middle domain TOPB45_1377 13567b412aa5b5f83f80c026096c1f45 592 Pfam PF13167 GTP-binding GTPase N-terminal 222 310 2.1E-31 T 13-10-2018 IPR025121 GTPase HflX, N-terminal TOPB45_1377 13567b412aa5b5f83f80c026096c1f45 592 Gene3D G3DSA:3.40.50.300 396 570 1.4E-40 T 13-10-2018 TOPB45_1377 13567b412aa5b5f83f80c026096c1f45 592 Hamap MF_00900 GTPase HflX [hflX]. 225 583 44.058 T 13-10-2018 IPR016496 GTPase HflX GO:0005525 TOPB45_1377 13567b412aa5b5f83f80c026096c1f45 592 SUPERFAMILY SSF52540 397 563 1.25E-39 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1377 13567b412aa5b5f83f80c026096c1f45 592 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 397 559 1.1E-14 T 13-10-2018 IPR005225 Small GTP-binding protein domain GO:0005525 TOPB45_1377 13567b412aa5b5f83f80c026096c1f45 592 Gene3D G3DSA:3.40.50.11060 214 338 3.2E-40 T 13-10-2018 TOPB45_0902 a1d9c8d8b6955c42e6aa3a43625fcbad 938 Gene3D G3DSA:3.40.50.620 25 633 1.3E-250 T 13-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TOPB45_0902 a1d9c8d8b6955c42e6aa3a43625fcbad 938 Hamap MF_02002 Isoleucine--tRNA ligase [ileS]. 1 933 20.341 T 13-10-2018 IPR023585 Isoleucine-tRNA ligase, type 1 GO:0004822 KEGG: 00970+6.1.1.5|Reactome: R-HSA-379726 TOPB45_0902 a1d9c8d8b6955c42e6aa3a43625fcbad 938 PRINTS PR00984 Isoleucyl-tRNA synthetase signature 238 261 1.1E-32 T 13-10-2018 IPR002301 Isoleucine-tRNA ligase GO:0000166|GO:0004822|GO:0005524|GO:0005737|GO:0006428 KEGG: 00970+6.1.1.5 TOPB45_0902 a1d9c8d8b6955c42e6aa3a43625fcbad 938 PRINTS PR00984 Isoleucyl-tRNA synthetase signature 400 415 1.1E-32 T 13-10-2018 IPR002301 Isoleucine-tRNA ligase GO:0000166|GO:0004822|GO:0005524|GO:0005737|GO:0006428 KEGG: 00970+6.1.1.5 TOPB45_0902 a1d9c8d8b6955c42e6aa3a43625fcbad 938 PRINTS PR00984 Isoleucyl-tRNA synthetase signature 50 61 1.1E-32 T 13-10-2018 IPR002301 Isoleucine-tRNA ligase GO:0000166|GO:0004822|GO:0005524|GO:0005737|GO:0006428 KEGG: 00970+6.1.1.5 TOPB45_0902 a1d9c8d8b6955c42e6aa3a43625fcbad 938 PRINTS PR00984 Isoleucyl-tRNA synthetase signature 565 574 1.1E-32 T 13-10-2018 IPR002301 Isoleucine-tRNA ligase GO:0000166|GO:0004822|GO:0005524|GO:0005737|GO:0006428 KEGG: 00970+6.1.1.5 TOPB45_0902 a1d9c8d8b6955c42e6aa3a43625fcbad 938 PRINTS PR00984 Isoleucyl-tRNA synthetase signature 531 544 1.1E-32 T 13-10-2018 IPR002301 Isoleucine-tRNA ligase GO:0000166|GO:0004822|GO:0005524|GO:0005737|GO:0006428 KEGG: 00970+6.1.1.5 TOPB45_0902 a1d9c8d8b6955c42e6aa3a43625fcbad 938 Pfam PF08264 Anticodon-binding domain of tRNA 689 834 3.8E-29 T 13-10-2018 IPR013155 Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding GO:0004812|GO:0006418 TOPB45_0902 a1d9c8d8b6955c42e6aa3a43625fcbad 938 SUPERFAMILY SSF47323 656 934 2.43E-62 T 13-10-2018 IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 TOPB45_0902 a1d9c8d8b6955c42e6aa3a43625fcbad 938 Gene3D G3DSA:3.90.740.10 194 407 1.3E-250 T 13-10-2018 IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain GO:0002161|GO:0006418 TOPB45_0902 a1d9c8d8b6955c42e6aa3a43625fcbad 938 Pfam PF00133 tRNA synthetases class I (I, L, M and V) 28 645 6.1E-204 T 13-10-2018 IPR002300 Aminoacyl-tRNA synthetase, class Ia GO:0000166|GO:0004812|GO:0005524|GO:0006418 TOPB45_0902 a1d9c8d8b6955c42e6aa3a43625fcbad 938 TIGRFAM TIGR00392 ileS: isoleucine--tRNA ligase 13 835 6.9E-290 T 13-10-2018 IPR002301 Isoleucine-tRNA ligase GO:0000166|GO:0004822|GO:0005524|GO:0005737|GO:0006428 KEGG: 00970+6.1.1.5 TOPB45_0902 a1d9c8d8b6955c42e6aa3a43625fcbad 938 SUPERFAMILY SSF52374 1 651 1.18E-144 T 13-10-2018 TOPB45_0902 a1d9c8d8b6955c42e6aa3a43625fcbad 938 Gene3D G3DSA:1.10.730.20 644 936 7.9E-90 T 13-10-2018 TOPB45_0902 a1d9c8d8b6955c42e6aa3a43625fcbad 938 SUPERFAMILY SSF50677 204 402 8.27E-58 T 13-10-2018 IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain GO:0002161|GO:0006418 TOPB45_0902 a1d9c8d8b6955c42e6aa3a43625fcbad 938 ProSitePatterns PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 57 68 - T 13-10-2018 IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site GO:0000166|GO:0004812|GO:0005524|GO:0006418 TOPB45_0401 8bdb0d1577752fba09e68b94d2e9f0d7 327 Pfam PF01370 NAD dependent epimerase/dehydratase family 8 255 1.3E-52 T 13-10-2018 IPR001509 NAD-dependent epimerase/dehydratase GO:0003824|GO:0050662 TOPB45_0401 8bdb0d1577752fba09e68b94d2e9f0d7 327 Gene3D G3DSA:3.40.50.720 8 255 3.9E-118 T 13-10-2018 TOPB45_0401 8bdb0d1577752fba09e68b94d2e9f0d7 327 SUPERFAMILY SSF51735 5 325 4.48E-90 T 13-10-2018 IPR036291 NAD(P)-binding domain superfamily TOPB45_0401 8bdb0d1577752fba09e68b94d2e9f0d7 327 TIGRFAM TIGR01179 galE: UDP-glucose 4-epimerase GalE 7 326 2.3E-131 T 13-10-2018 IPR005886 UDP-glucose 4-epimerase GO:0003978|GO:0006012 KEGG: 00052+5.1.3.2|KEGG: 00520+5.1.3.2|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6397|MetaCyc: PWY-6527|MetaCyc: PWY-7328|MetaCyc: PWY-7344|Reactome: R-HSA-5609977|Reactome: R-HSA-70370 TOPB45_0401 8bdb0d1577752fba09e68b94d2e9f0d7 327 Gene3D G3DSA:3.90.25.10 176 309 3.9E-118 T 13-10-2018 TOPB45_0726 cdecbc68c575540a0954324a4847cd67 175 PIRSF PIRSF004982 1 175 3.4E-51 T 13-10-2018 IPR004658 Outer membrane lipoprotein Slp GO:0019867 TOPB45_0726 cdecbc68c575540a0954324a4847cd67 175 TIGRFAM TIGR00752 slp: outer membrane lipoprotein, Slp family 6 171 1.6E-27 T 13-10-2018 IPR004658 Outer membrane lipoprotein Slp GO:0019867 TOPB45_0726 cdecbc68c575540a0954324a4847cd67 175 Pfam PF03843 Outer membrane lipoprotein Slp family 15 166 2.9E-48 T 13-10-2018 IPR004658 Outer membrane lipoprotein Slp GO:0019867 TOPB45_0626 8c913a1e8a13a18fcb0849a8db78fd72 210 Gene3D G3DSA:1.20.58.220 8 205 8.2E-24 T 13-10-2018 IPR038078 PhoU-like domain superfamily TOPB45_0626 8c913a1e8a13a18fcb0849a8db78fd72 210 Pfam PF01865 Protein of unknown function DUF47 8 205 2.9E-29 T 13-10-2018 IPR018445 Putative phosphate transport regulator TOPB45_0626 8c913a1e8a13a18fcb0849a8db78fd72 210 TIGRFAM TIGR00153 TIGR00153: TIGR00153 family protein 3 207 9.7E-31 T 13-10-2018 IPR002727 Protein of unknown function DUF47 TOPB45_0796 27480f0c19bdb0ecc8b4aef66918f207 580 SUPERFAMILY SSF56731 108 415 9.15E-84 T 13-10-2018 TOPB45_0796 27480f0c19bdb0ecc8b4aef66918f207 580 Pfam PF01807 CHC2 zinc finger 6 96 8.4E-36 T 13-10-2018 IPR002694 Zinc finger, CHC2-type GO:0003677|GO:0003896|GO:0006260|GO:0008270 TOPB45_0796 27480f0c19bdb0ecc8b4aef66918f207 580 Gene3D G3DSA:3.90.580.10 2 98 1.2E-38 T 13-10-2018 IPR036977 DNA Primase, CHC2-type zinc finger GO:0003677|GO:0006260|GO:0008270 TOPB45_0796 27480f0c19bdb0ecc8b4aef66918f207 580 SMART SM00493 253 324 1.1E-8 T 13-10-2018 IPR006171 TOPRIM domain TOPB45_0796 27480f0c19bdb0ecc8b4aef66918f207 580 Gene3D G3DSA:3.90.980.10 101 234 1.3E-38 T 13-10-2018 IPR037068 DNA primase, catalytic core, N-terminal domain superfamily TOPB45_0796 27480f0c19bdb0ecc8b4aef66918f207 580 PIRSF PIRSF002811 1 572 5.1E-153 T 13-10-2018 IPR030846 DNA primase DnaG, bacteria GO:0003896|GO:0006269|GO:0008270 TOPB45_0796 27480f0c19bdb0ecc8b4aef66918f207 580 Hamap MF_00974 DNA primase [dnaG]. 1 564 26.624 T 13-10-2018 IPR030846 DNA primase DnaG, bacteria GO:0003896|GO:0006269|GO:0008270 TOPB45_0796 27480f0c19bdb0ecc8b4aef66918f207 580 SMART SM00400 33 87 1.6E-29 T 13-10-2018 IPR002694 Zinc finger, CHC2-type GO:0003677|GO:0003896|GO:0006260|GO:0008270 TOPB45_0796 27480f0c19bdb0ecc8b4aef66918f207 580 Gene3D G3DSA:3.40.1360.10 235 357 1.6E-34 T 13-10-2018 TOPB45_0796 27480f0c19bdb0ecc8b4aef66918f207 580 TIGRFAM TIGR01391 dnaG: DNA primase 4 406 3.7E-129 T 13-10-2018 IPR006295 DNA primase, DnaG GO:0003896|GO:0006269 TOPB45_0796 27480f0c19bdb0ecc8b4aef66918f207 580 Pfam PF13155 Toprim-like 256 338 2.2E-14 T 13-10-2018 TOPB45_0796 27480f0c19bdb0ecc8b4aef66918f207 580 Pfam PF08275 DNA primase catalytic core, N-terminal domain 118 245 2.8E-38 T 13-10-2018 IPR013264 DNA primase, catalytic core, N-terminal TOPB45_0796 27480f0c19bdb0ecc8b4aef66918f207 580 SUPERFAMILY SSF57783 3 95 1.39E-34 T 13-10-2018 TOPB45_0124 3e4b4c85e3e54d2c5f621a6a5badd387 318 TIGRFAM TIGR02195 heptsyl_trn_II: lipopolysaccharide heptosyltransferase II 5 317 1.4E-64 T 13-10-2018 IPR011910 ADP-heptose--LPS heptosyltransferase 2 GO:0009103|GO:0016757 TOPB45_0124 3e4b4c85e3e54d2c5f621a6a5badd387 318 SUPERFAMILY SSF53756 3 317 3.3E-81 T 13-10-2018 TOPB45_0124 3e4b4c85e3e54d2c5f621a6a5badd387 318 Pfam PF01075 Glycosyltransferase family 9 (heptosyltransferase) 69 298 1.4E-57 T 13-10-2018 IPR002201 Glycosyl transferase, family 9 GO:0016757 TOPB45_0124 3e4b4c85e3e54d2c5f621a6a5badd387 318 Gene3D G3DSA:3.40.50.2000 143 318 1.6E-57 T 13-10-2018 TOPB45_0124 3e4b4c85e3e54d2c5f621a6a5badd387 318 Gene3D G3DSA:3.40.50.2000 1 137 1.0E-23 T 13-10-2018 TOPB45_0217 c7035c5af87977426706a19f80d6553b 308 PRINTS PR00086 L-lactate dehydrogenase signature 28 52 2.8E-34 T 13-10-2018 IPR001557 L-lactate/malate dehydrogenase GO:0016616|GO:0019752|GO:0055114 TOPB45_0217 c7035c5af87977426706a19f80d6553b 308 PRINTS PR00086 L-lactate dehydrogenase signature 116 136 2.8E-34 T 13-10-2018 IPR001557 L-lactate/malate dehydrogenase GO:0016616|GO:0019752|GO:0055114 TOPB45_0217 c7035c5af87977426706a19f80d6553b 308 PRINTS PR00086 L-lactate dehydrogenase signature 140 158 2.8E-34 T 13-10-2018 IPR001557 L-lactate/malate dehydrogenase GO:0016616|GO:0019752|GO:0055114 TOPB45_0217 c7035c5af87977426706a19f80d6553b 308 PRINTS PR00086 L-lactate dehydrogenase signature 170 183 2.8E-34 T 13-10-2018 IPR001557 L-lactate/malate dehydrogenase GO:0016616|GO:0019752|GO:0055114 TOPB45_0217 c7035c5af87977426706a19f80d6553b 308 PRINTS PR00086 L-lactate dehydrogenase signature 3 27 2.8E-34 T 13-10-2018 IPR001557 L-lactate/malate dehydrogenase GO:0016616|GO:0019752|GO:0055114 TOPB45_0217 c7035c5af87977426706a19f80d6553b 308 Gene3D G3DSA:3.40.50.720 2 144 3.7E-52 T 13-10-2018 TOPB45_0217 c7035c5af87977426706a19f80d6553b 308 Pfam PF00056 lactate/malate dehydrogenase, NAD binding domain 3 142 2.6E-42 T 13-10-2018 IPR001236 Lactate/malate dehydrogenase, N-terminal GO:0016491|GO:0055114 TOPB45_0217 c7035c5af87977426706a19f80d6553b 308 TIGRFAM TIGR01763 MalateDH_bact: malate dehydrogenase, NAD-dependent 3 302 3.6E-121 T 13-10-2018 IPR011275 Malate dehydrogenase, type 3 GO:0016616|GO:0055114 KEGG: 00020+1.1.1.37|KEGG: 00270+1.1.1.37|KEGG: 00620+1.1.1.37|KEGG: 00630+1.1.1.37|KEGG: 00680+1.1.1.37|KEGG: 00710+1.1.1.37|KEGG: 00720+1.1.1.37|MetaCyc: PWY-1622|MetaCyc: PWY-5392|MetaCyc: PWY-561|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7115|MetaCyc: PWY-7383 TOPB45_0217 c7035c5af87977426706a19f80d6553b 308 PIRSF PIRSF000102 1 307 1.4E-106 T 13-10-2018 IPR001557 L-lactate/malate dehydrogenase GO:0016616|GO:0019752|GO:0055114 TOPB45_0217 c7035c5af87977426706a19f80d6553b 308 Hamap MF_00487 Malate dehydrogenase [mdh]. 2 307 41.56 T 13-10-2018 IPR011275 Malate dehydrogenase, type 3 GO:0016616|GO:0055114 KEGG: 00020+1.1.1.37|KEGG: 00270+1.1.1.37|KEGG: 00620+1.1.1.37|KEGG: 00630+1.1.1.37|KEGG: 00680+1.1.1.37|KEGG: 00710+1.1.1.37|KEGG: 00720+1.1.1.37|MetaCyc: PWY-1622|MetaCyc: PWY-5392|MetaCyc: PWY-561|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7115|MetaCyc: PWY-7383 TOPB45_0217 c7035c5af87977426706a19f80d6553b 308 Gene3D G3DSA:3.90.110.10 145 307 2.9E-58 T 13-10-2018 IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal GO:0003824|GO:0005975|GO:0016616|GO:0055114 TOPB45_0217 c7035c5af87977426706a19f80d6553b 308 SUPERFAMILY SSF51735 3 143 7.98E-48 T 13-10-2018 IPR036291 NAD(P)-binding domain superfamily TOPB45_0217 c7035c5af87977426706a19f80d6553b 308 Pfam PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 146 302 5.0E-30 T 13-10-2018 IPR022383 Lactate/malate dehydrogenase, C-terminal GO:0016616|GO:0055114 TOPB45_0217 c7035c5af87977426706a19f80d6553b 308 SUPERFAMILY SSF56327 144 304 3.6E-51 T 13-10-2018 IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal GO:0003824|GO:0005975|GO:0016616|GO:0055114 TOPB45_0211 d154193d84bf30935604ea03aba62a4b 197 Pfam PF01965 DJ-1/PfpI family 28 191 8.2E-42 T 13-10-2018 IPR002818 DJ-1/PfpI Reactome: R-HSA-3899300 TOPB45_0211 d154193d84bf30935604ea03aba62a4b 197 SUPERFAMILY SSF52317 28 194 1.52E-41 T 13-10-2018 IPR029062 Class I glutamine amidotransferase-like TOPB45_0211 d154193d84bf30935604ea03aba62a4b 197 Gene3D G3DSA:3.40.50.880 23 196 4.1E-51 T 13-10-2018 IPR029062 Class I glutamine amidotransferase-like TOPB45_0103 222e0256e4e558f591f0960a12689918 148 SMART SM00881 22 116 3.9E-21 T 13-10-2018 IPR003781 CoA-binding GO:0048037 TOPB45_0103 222e0256e4e558f591f0960a12689918 148 Gene3D G3DSA:3.40.50.720 13 147 8.6E-41 T 13-10-2018 TOPB45_0103 222e0256e4e558f591f0960a12689918 148 Pfam PF13380 CoA binding domain 26 141 1.5E-38 T 13-10-2018 IPR003781 CoA-binding GO:0048037 TOPB45_0103 222e0256e4e558f591f0960a12689918 148 SUPERFAMILY SSF51735 16 143 3.94E-39 T 13-10-2018 IPR036291 NAD(P)-binding domain superfamily TOPB45_1478 01f46a63d410122c1ecd709d4495a962 419 TIGRFAM TIGR01953 NusA: transcription termination factor NusA 7 349 3.4E-120 T 13-10-2018 IPR010213 Transcription termination factor NusA GO:0003723 TOPB45_1478 01f46a63d410122c1ecd709d4495a962 419 Gene3D G3DSA:3.30.300.20 197 284 3.5E-31 T 13-10-2018 IPR015946 K homology domain-like, alpha/beta TOPB45_1478 01f46a63d410122c1ecd709d4495a962 419 Hamap MF_00945_B Transcription termination/antitermination protein NusA [nusA]. 2 414 29.701 T 13-10-2018 IPR030842 Transcription termination/antitermination protein NusA, bacterial GO:0006353|GO:0031564 TOPB45_1478 01f46a63d410122c1ecd709d4495a962 419 SMART SM00316 133 198 2.3E-5 T 13-10-2018 IPR022967 RNA-binding domain, S1 TOPB45_1478 01f46a63d410122c1ecd709d4495a962 419 SUPERFAMILY SSF69705 1 125 4.32E-34 T 13-10-2018 IPR036555 NusA, N-terminal domain superfamily GO:0003700|GO:0031554 TOPB45_1478 01f46a63d410122c1ecd709d4495a962 419 Gene3D G3DSA:3.30.300.20 286 419 2.8E-41 T 13-10-2018 IPR015946 K homology domain-like, alpha/beta TOPB45_1478 01f46a63d410122c1ecd709d4495a962 419 SUPERFAMILY SSF54814 198 284 2.09E-26 T 13-10-2018 IPR009019 K homology domain superfamily, prokaryotic type GO:0003723 TOPB45_1478 01f46a63d410122c1ecd709d4495a962 419 Pfam PF13184 NusA-like KH domain 228 304 6.8E-27 T 13-10-2018 IPR025249 KH domain, NusA-like GO:0003723 TOPB45_1478 01f46a63d410122c1ecd709d4495a962 419 SUPERFAMILY SSF50249 131 197 3.79E-13 T 13-10-2018 IPR012340 Nucleic acid-binding, OB-fold TOPB45_1478 01f46a63d410122c1ecd709d4495a962 419 SMART SM00322 308 418 5.2E-5 T 13-10-2018 IPR004087 K Homology domain GO:0003676 TOPB45_1478 01f46a63d410122c1ecd709d4495a962 419 SMART SM00322 228 300 13.0 T 13-10-2018 IPR004087 K Homology domain GO:0003676 TOPB45_1478 01f46a63d410122c1ecd709d4495a962 419 Gene3D G3DSA:2.40.50.140 135 196 1.1E-19 T 13-10-2018 TOPB45_1478 01f46a63d410122c1ecd709d4495a962 419 SUPERFAMILY SSF54814 286 349 2.88E-17 T 13-10-2018 IPR009019 K homology domain superfamily, prokaryotic type GO:0003723 TOPB45_1478 01f46a63d410122c1ecd709d4495a962 419 Pfam PF08529 NusA N-terminal domain 4 123 1.9E-33 T 13-10-2018 IPR013735 Transcription factor NusA, N-terminal GO:0003700|GO:0031554 TOPB45_1478 01f46a63d410122c1ecd709d4495a962 419 Gene3D G3DSA:3.30.1480.10 1 124 4.9E-37 T 13-10-2018 IPR036555 NusA, N-terminal domain superfamily GO:0003700|GO:0031554 TOPB45_1478 01f46a63d410122c1ecd709d4495a962 419 SUPERFAMILY SSF47794 361 416 1.73E-6 T 13-10-2018 IPR010995 DNA repair Rad51/transcription factor NusA, alpha-helical GO:0000166 Reactome: R-HSA-912446 TOPB45_0867 34d1c944703f03831e30544e3b5b1b70 217 Gene3D G3DSA:1.10.150.520 21 93 5.8E-28 T 13-10-2018 TOPB45_0867 34d1c944703f03831e30544e3b5b1b70 217 TIGRFAM TIGR01549 HAD-SF-IA-v1: HAD hydrolase, family IA, variant 1 79 185 8.2E-8 T 13-10-2018 IPR006439 HAD hydrolase, subfamily IA GO:0016787 TOPB45_0867 34d1c944703f03831e30544e3b5b1b70 217 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 7 18 2.5E-5 T 13-10-2018 IPR006439 HAD hydrolase, subfamily IA GO:0016787 TOPB45_0867 34d1c944703f03831e30544e3b5b1b70 217 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 104 117 2.5E-5 T 13-10-2018 IPR006439 HAD hydrolase, subfamily IA GO:0016787 TOPB45_0867 34d1c944703f03831e30544e3b5b1b70 217 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 152 172 2.5E-5 T 13-10-2018 IPR006439 HAD hydrolase, subfamily IA GO:0016787 TOPB45_0867 34d1c944703f03831e30544e3b5b1b70 217 SUPERFAMILY SSF56784 6 215 4.2E-30 T 13-10-2018 IPR036412 HAD-like superfamily TOPB45_0867 34d1c944703f03831e30544e3b5b1b70 217 Pfam PF13419 Haloacid dehalogenase-like hydrolase 12 189 5.5E-12 T 13-10-2018 TOPB45_0867 34d1c944703f03831e30544e3b5b1b70 217 Gene3D G3DSA:3.40.50.1000 8 201 5.8E-28 T 13-10-2018 IPR023214 HAD superfamily TOPB45_1017 5e522fadde6f3a7d67e94d39480778b8 238 Gene3D G3DSA:3.40.1160.10 1 238 9.7E-77 T 13-10-2018 IPR036393 Acetylglutamate kinase-like superfamily TOPB45_1017 5e522fadde6f3a7d67e94d39480778b8 238 Pfam PF00696 Amino acid kinase family 7 216 1.7E-27 T 13-10-2018 IPR001048 Aspartate/glutamate/uridylate kinase Reactome: R-HSA-70614 TOPB45_1017 5e522fadde6f3a7d67e94d39480778b8 238 SUPERFAMILY SSF53633 4 238 9.82E-69 T 13-10-2018 IPR036393 Acetylglutamate kinase-like superfamily TOPB45_1017 5e522fadde6f3a7d67e94d39480778b8 238 Hamap MF_01220_B Uridylate kinase [pyrH]. 4 237 42.603 T 13-10-2018 IPR015963 Uridylate kinase, bacteria GO:0005737|GO:0006221|GO:0033862 KEGG: 00240+2.7.4.22 TOPB45_1017 5e522fadde6f3a7d67e94d39480778b8 238 PIRSF PIRSF005650 1 238 1.7E-91 T 13-10-2018 IPR011817 Uridylate kinase GO:0006221|GO:0009041 KEGG: 00240+2.7.4.22 TOPB45_1017 5e522fadde6f3a7d67e94d39480778b8 238 TIGRFAM TIGR02075 pyrH_bact: UMP kinase 6 237 1.9E-95 T 13-10-2018 IPR015963 Uridylate kinase, bacteria GO:0005737|GO:0006221|GO:0033862 KEGG: 00240+2.7.4.22 TOPB45_1453 18ce3f683543c31ab8619650ae943aea 321 TIGRFAM TIGR00374 TIGR00374: TIGR00374 family protein 13 314 1.2E-37 T 13-10-2018 IPR022791 Lysylphosphatidylglycerol synthetase/glycosyltransferase AglD TOPB45_1453 18ce3f683543c31ab8619650ae943aea 321 Pfam PF03706 Lysylphosphatidylglycerol synthase TM region 15 304 3.1E-31 T 13-10-2018 IPR022791 Lysylphosphatidylglycerol synthetase/glycosyltransferase AglD TOPB45_1594 5f7ef3f355598f809ba8d6ab54a32f9c 520 SMART SM00471 332 438 3.6E-12 T 13-10-2018 IPR003607 HD/PDEase domain TOPB45_1594 5f7ef3f355598f809ba8d6ab54a32f9c 520 Pfam PF01966 HD domain 336 427 2.7E-19 T 13-10-2018 IPR006674 HD domain TOPB45_1594 5f7ef3f355598f809ba8d6ab54a32f9c 520 TIGRFAM TIGR00277 HDIG: HDIG domain 332 409 9.2E-25 T 13-10-2018 IPR006675 HDIG domain TOPB45_1594 5f7ef3f355598f809ba8d6ab54a32f9c 520 Pfam PF00013 KH domain 213 267 2.4E-5 T 13-10-2018 IPR004088 K Homology domain, type 1 GO:0003723 TOPB45_1594 5f7ef3f355598f809ba8d6ab54a32f9c 520 SUPERFAMILY SSF54791 207 296 3.8E-15 T 13-10-2018 IPR036612 K Homology domain, type 1 superfamily GO:0003723 TOPB45_1594 5f7ef3f355598f809ba8d6ab54a32f9c 520 Pfam PF12072 Domain of unknown function (DUF3552) 17 202 2.7E-33 T 13-10-2018 IPR022711 Ribonuclease Y, N-terminal TOPB45_1594 5f7ef3f355598f809ba8d6ab54a32f9c 520 Gene3D G3DSA:1.10.3210.10 319 495 1.0E-22 T 13-10-2018 TOPB45_1594 5f7ef3f355598f809ba8d6ab54a32f9c 520 Gene3D G3DSA:3.30.1370.10 207 305 2.9E-8 T 13-10-2018 IPR036612 K Homology domain, type 1 superfamily GO:0003723 TOPB45_1594 5f7ef3f355598f809ba8d6ab54a32f9c 520 SUPERFAMILY SSF109604 313 471 1.13E-31 T 13-10-2018 TOPB45_1594 5f7ef3f355598f809ba8d6ab54a32f9c 520 Hamap MF_00335 Ribonuclease Y [rny]. 2 520 24.168 T 13-10-2018 IPR017705 Ribonuclease Y GO:0003723|GO:0006402|GO:0016020 TOPB45_1594 5f7ef3f355598f809ba8d6ab54a32f9c 520 TIGRFAM TIGR03319 RNase_Y: ribonuclease Y 5 520 3.4E-206 T 13-10-2018 IPR017705 Ribonuclease Y GO:0003723|GO:0006402|GO:0016020 TOPB45_1594 5f7ef3f355598f809ba8d6ab54a32f9c 520 SMART SM00322 208 275 1.0E-7 T 13-10-2018 IPR004087 K Homology domain GO:0003676 TOPB45_0459 6087c16ad6e1a00a0af55868b471bd6b 357 SUPERFAMILY SSF47384 112 182 2.55E-7 T 13-10-2018 IPR036097 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily GO:0000155|GO:0007165 TOPB45_0459 6087c16ad6e1a00a0af55868b471bd6b 357 PRINTS PR00344 Bacterial sensor protein C-terminal signature 303 321 3.3E-6 T 13-10-2018 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TOPB45_0459 6087c16ad6e1a00a0af55868b471bd6b 357 PRINTS PR00344 Bacterial sensor protein C-terminal signature 273 287 3.3E-6 T 13-10-2018 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TOPB45_0459 6087c16ad6e1a00a0af55868b471bd6b 357 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 235 340 2.1E-13 T 13-10-2018 IPR003594 Histidine kinase/HSP90-like ATPase TOPB45_0459 6087c16ad6e1a00a0af55868b471bd6b 357 Gene3D G3DSA:3.30.565.10 187 341 1.0E-32 T 13-10-2018 IPR036890 Histidine kinase/HSP90-like ATPase superfamily TOPB45_0459 6087c16ad6e1a00a0af55868b471bd6b 357 SMART SM00388 121 188 3.1E-4 T 13-10-2018 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TOPB45_0459 6087c16ad6e1a00a0af55868b471bd6b 357 SMART SM00387 235 343 1.7E-20 T 13-10-2018 IPR003594 Histidine kinase/HSP90-like ATPase TOPB45_0459 6087c16ad6e1a00a0af55868b471bd6b 357 Gene3D G3DSA:1.10.287.130 110 186 1.0E-7 T 13-10-2018 TOPB45_0459 6087c16ad6e1a00a0af55868b471bd6b 357 SUPERFAMILY SSF55874 191 341 7.2E-30 T 13-10-2018 IPR036890 Histidine kinase/HSP90-like ATPase superfamily TOPB45_0459 6087c16ad6e1a00a0af55868b471bd6b 357 Pfam PF00512 His Kinase A (phospho-acceptor) domain 126 186 2.5E-7 T 13-10-2018 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TOPB45_0096 9df5da8c3a1c4945620e43a2deb67436 323 ProSitePatterns PS00668 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. 208 221 - T 13-10-2018 IPR018086 NADH:ubiquinone oxidoreductase, subunit 1, conserved site GO:0016020|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_0096 9df5da8c3a1c4945620e43a2deb67436 323 Hamap MF_01350 NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic [ndhA]. 4 323 25.584 T 13-10-2018 IPR001694 NADH:ubiquinone oxidoreductase, subunit 1/F420H2 oxidoreductase subunit H GO:0016020|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_0096 9df5da8c3a1c4945620e43a2deb67436 323 Pfam PF00146 NADH dehydrogenase 11 317 2.6E-125 T 13-10-2018 IPR001694 NADH:ubiquinone oxidoreductase, subunit 1/F420H2 oxidoreductase subunit H GO:0016020|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_0096 9df5da8c3a1c4945620e43a2deb67436 323 ProSitePatterns PS00667 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. 50 65 - T 13-10-2018 IPR018086 NADH:ubiquinone oxidoreductase, subunit 1, conserved site GO:0016020|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_0412 d0aeba34802e5ef11da84764facea45a 184 Pfam PF03938 Outer membrane protein (OmpH-like) 22 170 6.6E-31 T 13-10-2018 IPR005632 Chaperone protein Skp GO:0051082 TOPB45_0412 d0aeba34802e5ef11da84764facea45a 184 SMART SM00935 14 173 1.6E-32 T 13-10-2018 IPR005632 Chaperone protein Skp GO:0051082 TOPB45_0412 d0aeba34802e5ef11da84764facea45a 184 SUPERFAMILY SSF111384 30 172 6.15E-26 T 13-10-2018 TOPB45_0412 d0aeba34802e5ef11da84764facea45a 184 Gene3D G3DSA:3.30.910.20 21 184 1.2E-32 T 13-10-2018 IPR024930 Skp domain superfamily TOPB45_0812 cf805e01fe225daf74006daa6b224ea0 410 Gene3D G3DSA:2.30.39.10 204 407 1.7E-138 T 13-10-2018 TOPB45_0812 cf805e01fe225daf74006daa6b224ea0 410 ProSitePatterns PS00284 Serpins signature. 380 390 - T 13-10-2018 IPR023795 Serpin, conserved site TOPB45_0812 cf805e01fe225daf74006daa6b224ea0 410 Pfam PF00079 Serpin (serine protease inhibitor) 35 407 3.7E-125 T 13-10-2018 IPR023796 Serpin domain TOPB45_0812 cf805e01fe225daf74006daa6b224ea0 410 SMART SM00093 40 407 1.3E-140 T 13-10-2018 IPR023796 Serpin domain TOPB45_0812 cf805e01fe225daf74006daa6b224ea0 410 SUPERFAMILY SSF56574 13 407 1.19E-131 T 13-10-2018 IPR036186 Serpin superfamily TOPB45_0812 cf805e01fe225daf74006daa6b224ea0 410 Gene3D G3DSA:3.30.497.10 37 353 1.7E-138 T 13-10-2018 TOPB45_1180 108a2c194de84873b4c441aaaa1a3bc0 252 SUPERFAMILY SSF55073 100 248 3.53E-42 T 13-10-2018 IPR029787 Nucleotide cyclase TOPB45_1180 108a2c194de84873b4c441aaaa1a3bc0 252 SUPERFAMILY SSF50037 14 83 8.47E-9 T 13-10-2018 IPR008988 Transcriptional repressor, C-terminal TOPB45_1180 108a2c194de84873b4c441aaaa1a3bc0 252 Pfam PF04023 FeoA domain 13 83 3.4E-13 T 13-10-2018 IPR007167 Ferrous iron transporter FeoA domain GO:0046914 TOPB45_1180 108a2c194de84873b4c441aaaa1a3bc0 252 Pfam PF00990 Diguanylate cyclase, GGDEF domain 95 245 1.0E-39 T 13-10-2018 IPR000160 GGDEF domain TOPB45_1180 108a2c194de84873b4c441aaaa1a3bc0 252 SMART SM00899 12 83 1.1E-8 T 13-10-2018 IPR007167 Ferrous iron transporter FeoA domain GO:0046914 TOPB45_1180 108a2c194de84873b4c441aaaa1a3bc0 252 TIGRFAM TIGR00254 GGDEF: diguanylate cyclase (GGDEF) domain 94 248 4.7E-40 T 13-10-2018 IPR000160 GGDEF domain TOPB45_1180 108a2c194de84873b4c441aaaa1a3bc0 252 SMART SM00267 84 250 1.2E-46 T 13-10-2018 IPR000160 GGDEF domain TOPB45_1180 108a2c194de84873b4c441aaaa1a3bc0 252 Gene3D G3DSA:2.30.30.90 13 86 3.5E-11 T 13-10-2018 IPR038157 Ferrous iron transporter, core domain TOPB45_1180 108a2c194de84873b4c441aaaa1a3bc0 252 Gene3D G3DSA:3.30.70.270 94 252 1.6E-46 T 13-10-2018 TOPB45_1447 4d5f0d4efcfe295f9e19f56ee6e62317 252 TIGRFAM TIGR00241 CoA_E_activ: putative CoA-substrate-specific enzyme activase 4 242 1.5E-66 T 13-10-2018 IPR008275 CoA enzyme activase TOPB45_1447 4d5f0d4efcfe295f9e19f56ee6e62317 252 SUPERFAMILY SSF53067 3 243 2.38E-37 T 13-10-2018 TOPB45_1447 4d5f0d4efcfe295f9e19f56ee6e62317 252 Gene3D G3DSA:3.30.420.40 89 229 5.7E-69 T 13-10-2018 TOPB45_1447 4d5f0d4efcfe295f9e19f56ee6e62317 252 Pfam PF01869 BadF/BadG/BcrA/BcrD ATPase family 51 245 1.6E-46 T 13-10-2018 IPR002731 ATPase, BadF/BadG/BcrA/BcrD type Reactome: R-HSA-446210 TOPB45_1447 4d5f0d4efcfe295f9e19f56ee6e62317 252 Gene3D G3DSA:3.30.420.40 4 243 5.7E-69 T 13-10-2018 TOPB45_1082 27ceeb47f4b34485016f06fbf3718a79 465 Pfam PF00749 tRNA synthetases class I (E and Q), catalytic domain 2 300 9.7E-106 T 13-10-2018 IPR020058 Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain GO:0004812|GO:0005524|GO:0043039 TOPB45_1082 27ceeb47f4b34485016f06fbf3718a79 465 SUPERFAMILY SSF52374 1 295 2.25E-113 T 13-10-2018 TOPB45_1082 27ceeb47f4b34485016f06fbf3718a79 465 SUPERFAMILY SSF48163 296 458 6.67E-39 T 13-10-2018 IPR008925 Aminoacyl-tRNA synthetase, class I, anticodon-binding GO:0000049 KEGG: 00860+6.1.1.17|KEGG: 00970+6.1.1.17|MetaCyc: PWY-5188|Reactome: R-HSA-379726 TOPB45_1082 27ceeb47f4b34485016f06fbf3718a79 465 PRINTS PR00987 Glutamyl-tRNA synthetase signature 192 200 3.2E-28 T 13-10-2018 IPR000924 Glutamyl/glutaminyl-tRNA synthetase GO:0000166|GO:0004812|GO:0005524|GO:0005737|GO:0043039 TOPB45_1082 27ceeb47f4b34485016f06fbf3718a79 465 PRINTS PR00987 Glutamyl-tRNA synthetase signature 176 186 3.2E-28 T 13-10-2018 IPR000924 Glutamyl/glutaminyl-tRNA synthetase GO:0000166|GO:0004812|GO:0005524|GO:0005737|GO:0043039 TOPB45_1082 27ceeb47f4b34485016f06fbf3718a79 465 PRINTS PR00987 Glutamyl-tRNA synthetase signature 34 47 3.2E-28 T 13-10-2018 IPR000924 Glutamyl/glutaminyl-tRNA synthetase GO:0000166|GO:0004812|GO:0005524|GO:0005737|GO:0043039 TOPB45_1082 27ceeb47f4b34485016f06fbf3718a79 465 PRINTS PR00987 Glutamyl-tRNA synthetase signature 5 17 3.2E-28 T 13-10-2018 IPR000924 Glutamyl/glutaminyl-tRNA synthetase GO:0000166|GO:0004812|GO:0005524|GO:0005737|GO:0043039 TOPB45_1082 27ceeb47f4b34485016f06fbf3718a79 465 PRINTS PR00987 Glutamyl-tRNA synthetase signature 19 30 3.2E-28 T 13-10-2018 IPR000924 Glutamyl/glutaminyl-tRNA synthetase GO:0000166|GO:0004812|GO:0005524|GO:0005737|GO:0043039 TOPB45_1082 27ceeb47f4b34485016f06fbf3718a79 465 Gene3D G3DSA:1.10.10.350 360 464 2.0E-25 T 13-10-2018 IPR020751 Aminoacyl-tRNA synthetase, class I, anticodon-binding domain, subdomain 2 KEGG: 00860+6.1.1.17|KEGG: 00970+6.1.1.17|MetaCyc: PWY-5188|Reactome: R-HSA-379726 TOPB45_1082 27ceeb47f4b34485016f06fbf3718a79 465 ProSitePatterns PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 8 19 - T 13-10-2018 IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site GO:0000166|GO:0004812|GO:0005524|GO:0006418 TOPB45_1082 27ceeb47f4b34485016f06fbf3718a79 465 Hamap MF_00022 Glutamate--tRNA ligase [gltX]. 1 458 33.289 T 13-10-2018 IPR004527 Glutamate-tRNA ligase, bacterial/mitochondrial GO:0000166|GO:0004818|GO:0005524|GO:0005737|GO:0006424 KEGG: 00860+6.1.1.17|KEGG: 00970+6.1.1.17|MetaCyc: PWY-5188|Reactome: R-HSA-379726 TOPB45_1082 27ceeb47f4b34485016f06fbf3718a79 465 TIGRFAM TIGR00464 gltX_bact: glutamate--tRNA ligase 2 462 8.8E-173 T 13-10-2018 IPR004527 Glutamate-tRNA ligase, bacterial/mitochondrial GO:0000166|GO:0004818|GO:0005524|GO:0005737|GO:0006424 KEGG: 00860+6.1.1.17|KEGG: 00970+6.1.1.17|MetaCyc: PWY-5188|Reactome: R-HSA-379726 TOPB45_1082 27ceeb47f4b34485016f06fbf3718a79 465 Gene3D G3DSA:3.40.50.620 1 311 5.1E-138 T 13-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TOPB45_1008 bd26931f0d2d00a3850c25336b2c94d6 872 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 203 319 1.7E-13 T 13-10-2018 IPR003959 ATPase, AAA-type, core GO:0005524 TOPB45_1008 bd26931f0d2d00a3850c25336b2c94d6 872 SUPERFAMILY SSF52540 549 852 1.35E-84 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1008 bd26931f0d2d00a3850c25336b2c94d6 872 SUPERFAMILY SSF52540 159 548 3.28E-102 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1008 bd26931f0d2d00a3850c25336b2c94d6 872 ProSitePatterns PS00871 Chaperonins clpA/B signature 2. 634 652 - T 13-10-2018 IPR028299 ClpA/B, conserved site 2 TOPB45_1008 bd26931f0d2d00a3850c25336b2c94d6 872 SUPERFAMILY SSF81923 4 156 1.77E-41 T 13-10-2018 IPR036628 Clp, N-terminal domain superfamily GO:0019538 TOPB45_1008 bd26931f0d2d00a3850c25336b2c94d6 872 Pfam PF07724 AAA domain (Cdc48 subfamily) 599 761 5.5E-58 T 13-10-2018 IPR003959 ATPase, AAA-type, core GO:0005524 TOPB45_1008 bd26931f0d2d00a3850c25336b2c94d6 872 TIGRFAM TIGR03346 chaperone_ClpB: ATP-dependent chaperone protein ClpB 6 852 0.0 T 13-10-2018 IPR017730 Chaperonin ClpB GO:0005737|GO:0009408|GO:0042026 TOPB45_1008 bd26931f0d2d00a3850c25336b2c94d6 872 Gene3D G3DSA:3.40.50.300 344 547 1.0E-72 T 13-10-2018 TOPB45_1008 bd26931f0d2d00a3850c25336b2c94d6 872 Gene3D G3DSA:1.10.8.60 767 869 1.3E-29 T 13-10-2018 TOPB45_1008 bd26931f0d2d00a3850c25336b2c94d6 872 Pfam PF10431 C-terminal, D2-small domain, of ClpB protein 767 847 6.2E-26 T 13-10-2018 IPR019489 Clp ATPase, C-terminal TOPB45_1008 bd26931f0d2d00a3850c25336b2c94d6 872 Pfam PF02861 Clp amino terminal domain, pathogenicity island component 17 68 1.3E-12 T 13-10-2018 IPR004176 Clp, N-terminal TOPB45_1008 bd26931f0d2d00a3850c25336b2c94d6 872 Pfam PF02861 Clp amino terminal domain, pathogenicity island component 94 144 6.9E-11 T 13-10-2018 IPR004176 Clp, N-terminal TOPB45_1008 bd26931f0d2d00a3850c25336b2c94d6 872 SMART SM01086 767 857 2.3E-38 T 13-10-2018 IPR019489 Clp ATPase, C-terminal TOPB45_1008 bd26931f0d2d00a3850c25336b2c94d6 872 ProSitePatterns PS00870 Chaperonins clpA/B signature 1. 294 306 - T 13-10-2018 IPR018368 ClpA/B, conserved site 1 GO:0005524 TOPB45_1008 bd26931f0d2d00a3850c25336b2c94d6 872 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 678 696 4.9E-44 T 13-10-2018 IPR001270 ClpA/B family GO:0005524 TOPB45_1008 bd26931f0d2d00a3850c25336b2c94d6 872 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 604 622 4.9E-44 T 13-10-2018 IPR001270 ClpA/B family GO:0005524 TOPB45_1008 bd26931f0d2d00a3850c25336b2c94d6 872 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 711 725 4.9E-44 T 13-10-2018 IPR001270 ClpA/B family GO:0005524 TOPB45_1008 bd26931f0d2d00a3850c25336b2c94d6 872 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 649 667 4.9E-44 T 13-10-2018 IPR001270 ClpA/B family GO:0005524 TOPB45_1008 bd26931f0d2d00a3850c25336b2c94d6 872 SMART SM00382 198 344 4.0E-9 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_1008 bd26931f0d2d00a3850c25336b2c94d6 872 SMART SM00382 600 768 4.7E-13 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_1008 bd26931f0d2d00a3850c25336b2c94d6 872 Gene3D G3DSA:1.10.1780.10 1 148 1.6E-36 T 13-10-2018 IPR036628 Clp, N-terminal domain superfamily GO:0019538 TOPB45_1008 bd26931f0d2d00a3850c25336b2c94d6 872 Gene3D G3DSA:3.40.50.300 553 766 3.8E-92 T 13-10-2018 TOPB45_1008 bd26931f0d2d00a3850c25336b2c94d6 872 Gene3D G3DSA:3.40.50.300 149 342 3.1E-78 T 13-10-2018 TOPB45_1536 a8424a7661e1324d0831bd8ddf527646 320 SUPERFAMILY SSF64182 4 316 8.11E-70 T 13-10-2018 IPR038763 DHH phosphoesterase superfamily TOPB45_1536 a8424a7661e1324d0831bd8ddf527646 320 SMART SM01131 191 317 5.1E-48 T 13-10-2018 IPR004097 DHHA2 domain GO:0005737|GO:0016462 KEGG: 00190+3.6.1.1|MetaCyc: PWY-7805|MetaCyc: PWY-7807 TOPB45_1536 a8424a7661e1324d0831bd8ddf527646 320 Gene3D G3DSA:3.90.1640.10 3 199 1.0E-66 T 13-10-2018 TOPB45_1536 a8424a7661e1324d0831bd8ddf527646 320 Pfam PF02833 DHHA2 domain 194 315 1.8E-20 T 13-10-2018 IPR004097 DHHA2 domain GO:0005737|GO:0016462 KEGG: 00190+3.6.1.1|MetaCyc: PWY-7805|MetaCyc: PWY-7807 TOPB45_1536 a8424a7661e1324d0831bd8ddf527646 320 Pfam PF01368 DHH family 5 155 5.0E-24 T 13-10-2018 IPR001667 DDH domain KEGG: 00190+3.6.1.1|MetaCyc: PWY-7805|MetaCyc: PWY-7807 TOPB45_1536 a8424a7661e1324d0831bd8ddf527646 320 Gene3D G3DSA:3.10.310.20 200 319 7.2E-38 T 13-10-2018 IPR038222 DHHA2 domain superfamily KEGG: 00190+3.6.1.1|MetaCyc: PWY-7805|MetaCyc: PWY-7807 TOPB45_0633 b54b89073d053da2df54e899ed64958c 699 Gene3D G3DSA:3.30.1490.20 503 580 3.5E-80 T 13-10-2018 IPR013815 ATP-grasp fold, subdomain 1 GO:0005524 TOPB45_0633 b54b89073d053da2df54e899ed64958c 699 SUPERFAMILY SSF56059 487 697 1.94E-43 T 13-10-2018 TOPB45_0633 b54b89073d053da2df54e899ed64958c 699 TIGRFAM TIGR02717 AcCoA-syn-alpha: acetyl coenzyme A synthetase (ADP forming), alpha domain 2 445 2.4E-182 T 13-10-2018 IPR014089 Acetate-CoA ligase [ADP-forming], alpha domain KEGG: 00010+6.2.1.13|KEGG: 00620+6.2.1.13|KEGG: 00640+6.2.1.13|MetaCyc: PWY-5483|MetaCyc: PWY-5535 TOPB45_0633 b54b89073d053da2df54e899ed64958c 699 Pfam PF13607 Succinyl-CoA ligase like flavodoxin domain 152 288 1.1E-54 T 13-10-2018 IPR032875 Succinyl-CoA synthetase-like, flavodoxin domain TOPB45_0633 b54b89073d053da2df54e899ed64958c 699 SUPERFAMILY SSF51735 2 137 1.73E-43 T 13-10-2018 IPR036291 NAD(P)-binding domain superfamily TOPB45_0633 b54b89073d053da2df54e899ed64958c 699 Pfam PF13549 ATP-grasp domain 483 696 1.7E-76 T 13-10-2018 TOPB45_0633 b54b89073d053da2df54e899ed64958c 699 Gene3D G3DSA:3.40.50.261 130 291 1.3E-61 T 13-10-2018 IPR016102 Succinyl-CoA synthetase-like KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 TOPB45_0633 b54b89073d053da2df54e899ed64958c 699 SMART SM00881 5 100 2.6E-41 T 13-10-2018 IPR003781 CoA-binding GO:0048037 TOPB45_0633 b54b89073d053da2df54e899ed64958c 699 SUPERFAMILY SSF52210 294 445 7.72E-31 T 13-10-2018 IPR016102 Succinyl-CoA synthetase-like KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 TOPB45_0633 b54b89073d053da2df54e899ed64958c 699 Pfam PF13380 CoA binding domain 10 135 2.7E-29 T 13-10-2018 IPR003781 CoA-binding GO:0048037 TOPB45_0633 b54b89073d053da2df54e899ed64958c 699 Gene3D G3DSA:3.30.470.20 487 694 3.5E-80 T 13-10-2018 TOPB45_0633 b54b89073d053da2df54e899ed64958c 699 Gene3D G3DSA:3.40.50.720 1 129 4.7E-50 T 13-10-2018 TOPB45_0633 b54b89073d053da2df54e899ed64958c 699 SUPERFAMILY SSF52210 129 287 3.92E-44 T 13-10-2018 IPR016102 Succinyl-CoA synthetase-like KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 TOPB45_0633 b54b89073d053da2df54e899ed64958c 699 Gene3D G3DSA:3.40.50.261 293 456 3.8E-47 T 13-10-2018 IPR016102 Succinyl-CoA synthetase-like KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 TOPB45_1149 9e4b56399f144681b2d48aeaaf08c0a2 205 Gene3D G3DSA:3.90.950.10 2 202 6.3E-77 T 13-10-2018 IPR029001 Inosine triphosphate pyrophosphatase-like TOPB45_1149 9e4b56399f144681b2d48aeaaf08c0a2 205 TIGRFAM TIGR00042 TIGR00042: non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family 6 197 1.5E-58 T 13-10-2018 IPR002637 Ham1-like protein GO:0009143|GO:0047429 KEGG: 00230+3.6.1.66|Reactome: R-HSA-74259 TOPB45_1149 9e4b56399f144681b2d48aeaaf08c0a2 205 SUPERFAMILY SSF52972 6 199 2.62E-69 T 13-10-2018 IPR029001 Inosine triphosphate pyrophosphatase-like TOPB45_1149 9e4b56399f144681b2d48aeaaf08c0a2 205 Hamap MF_01405 dITP/XTP pyrophosphatase. 4 199 48.347 T 13-10-2018 IPR020922 dITP/XTP pyrophosphatase GO:0009143|GO:0017111 KEGG: 00230+3.6.1.66 TOPB45_1149 9e4b56399f144681b2d48aeaaf08c0a2 205 Pfam PF01725 Ham1 family 6 195 3.5E-57 T 13-10-2018 IPR002637 Ham1-like protein GO:0009143|GO:0047429 KEGG: 00230+3.6.1.66|Reactome: R-HSA-74259 TOPB45_1443 ff6707e681bbf95a881ee5f9837e751d 659 Gene3D G3DSA:3.30.230.10 442 646 1.1E-81 T 13-10-2018 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup TOPB45_1443 ff6707e681bbf95a881ee5f9837e751d 659 Gene3D G3DSA:3.30.70.870 370 441 1.3E-19 T 13-10-2018 TOPB45_1443 ff6707e681bbf95a881ee5f9837e751d 659 Pfam PF00679 Elongation factor G C-terminus 559 644 4.0E-24 T 13-10-2018 IPR000640 Elongation factor EFG, domain V-like TOPB45_1443 ff6707e681bbf95a881ee5f9837e751d 659 Pfam PF03764 Elongation factor G, domain IV 437 557 5.6E-43 T 13-10-2018 IPR005517 Translation elongation factor EFG/EF2, domain IV GO:0005525 TOPB45_1443 ff6707e681bbf95a881ee5f9837e751d 659 SUPERFAMILY SSF52540 5 254 1.52E-38 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1443 ff6707e681bbf95a881ee5f9837e751d 659 Pfam PF14492 Elongation Factor G, domain II 362 435 1.6E-21 T 13-10-2018 TOPB45_1443 ff6707e681bbf95a881ee5f9837e751d 659 SMART SM00838 559 646 4.2E-30 T 13-10-2018 IPR000640 Elongation factor EFG, domain V-like TOPB45_1443 ff6707e681bbf95a881ee5f9837e751d 659 Gene3D G3DSA:3.40.50.300 4 256 9.9E-38 T 13-10-2018 TOPB45_1443 ff6707e681bbf95a881ee5f9837e751d 659 SUPERFAMILY SSF54980 363 440 1.04E-16 T 13-10-2018 IPR035647 EF-G domain III/V-like TOPB45_1443 ff6707e681bbf95a881ee5f9837e751d 659 SMART SM00889 438 557 2.0E-62 T 13-10-2018 IPR005517 Translation elongation factor EFG/EF2, domain IV GO:0005525 TOPB45_1443 ff6707e681bbf95a881ee5f9837e751d 659 SUPERFAMILY SSF54211 437 558 1.14E-41 T 13-10-2018 IPR020568 Ribosomal protein S5 domain 2-type fold TOPB45_1443 ff6707e681bbf95a881ee5f9837e751d 659 Pfam PF00009 Elongation factor Tu GTP binding domain 48 251 1.3E-15 T 13-10-2018 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TOPB45_1443 ff6707e681bbf95a881ee5f9837e751d 659 SUPERFAMILY SSF50447 268 357 2.37E-13 T 13-10-2018 IPR009000 Translation protein, beta-barrel domain superfamily TOPB45_1443 ff6707e681bbf95a881ee5f9837e751d 659 Gene3D G3DSA:2.40.30.10 257 369 7.1E-21 T 13-10-2018 TOPB45_1443 ff6707e681bbf95a881ee5f9837e751d 659 SUPERFAMILY SSF54980 559 649 3.24E-23 T 13-10-2018 IPR035647 EF-G domain III/V-like TOPB45_1443 ff6707e681bbf95a881ee5f9837e751d 659 Gene3D G3DSA:3.30.70.240 563 633 1.1E-81 T 13-10-2018 TOPB45_0266 9ab9df130ef91041a670c0fcdf3c0393 218 SMART SM00478 39 198 5.7E-38 T 13-10-2018 IPR003265 HhH-GPD domain GO:0006284 Reactome: R-HSA-110357 TOPB45_0266 9ab9df130ef91041a670c0fcdf3c0393 218 Pfam PF00730 HhH-GPD superfamily base excision DNA repair protein 35 179 2.1E-17 T 13-10-2018 IPR003265 HhH-GPD domain GO:0006284 Reactome: R-HSA-110357 TOPB45_0266 9ab9df130ef91041a670c0fcdf3c0393 218 SUPERFAMILY SSF48150 5 215 1.73E-60 T 13-10-2018 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: R-HSA-110357 TOPB45_0266 9ab9df130ef91041a670c0fcdf3c0393 218 PIRSF PIRSF001435 1 216 1.5E-73 T 13-10-2018 TOPB45_0266 9ab9df130ef91041a670c0fcdf3c0393 218 Gene3D G3DSA:1.10.340.30 22 137 2.8E-35 T 13-10-2018 TOPB45_0266 9ab9df130ef91041a670c0fcdf3c0393 218 Gene3D G3DSA:1.10.1670.10 138 215 1.0E-16 T 13-10-2018 IPR023170 Helix-turn-helix, base-excision DNA repair, C-terminal Reactome: R-HSA-110357 TOPB45_1288 1704a195efe5bc7166611c34ecd0ee32 165 SUPERFAMILY SSF52016 2 162 1.96E-59 T 13-10-2018 TOPB45_1288 1704a195efe5bc7166611c34ecd0ee32 165 Gene3D G3DSA:3.20.19.10 1 165 1.8E-64 T 13-10-2018 IPR015928 Aconitase/3-isopropylmalate dehydratase, swivel KEGG: 00290+4.2.1.33 TOPB45_1288 1704a195efe5bc7166611c34ecd0ee32 165 Pfam PF00694 Aconitase C-terminal domain 40 108 3.7E-23 T 13-10-2018 IPR000573 Aconitase A/isopropylmalate dehydratase small subunit, swivel domain KEGG: 00290+4.2.1.33 TOPB45_1288 1704a195efe5bc7166611c34ecd0ee32 165 TIGRFAM TIGR02084 leud: 3-isopropylmalate dehydratase, small subunit 6 160 1.8E-74 T 13-10-2018 IPR011824 Hydrolyase LeuD/DmdB, bacterial GO:0016836 KEGG: 00290+4.2.1.33 TOPB45_1288 1704a195efe5bc7166611c34ecd0ee32 165 Hamap MF_01032 Methanogen homoaconitase small subunit [hacB]. 4 164 40.424 T 13-10-2018 IPR011827 Hydrolyase LeuD/HacB/DmdB GO:0016836 KEGG: 00290+4.2.1.33 TOPB45_1288 1704a195efe5bc7166611c34ecd0ee32 165 TIGRFAM TIGR02087 LEUD_arch: 3-isopropylmalate dehydratase, small subunit 6 161 7.3E-69 T 13-10-2018 IPR011827 Hydrolyase LeuD/HacB/DmdB GO:0016836 KEGG: 00290+4.2.1.33 TOPB45_0753 4cd52b0313f71641c1d82061845a1aab 215 SUPERFAMILY SSF50447 3 209 3.44E-71 T 13-10-2018 IPR009000 Translation protein, beta-barrel domain superfamily TOPB45_0753 4cd52b0313f71641c1d82061845a1aab 215 Gene3D G3DSA:2.40.30.10 138 213 3.3E-12 T 13-10-2018 TOPB45_0753 4cd52b0313f71641c1d82061845a1aab 215 Gene3D G3DSA:2.40.50.620 33 98 1.1E-15 T 13-10-2018 TOPB45_0753 4cd52b0313f71641c1d82061845a1aab 215 TIGRFAM TIGR03625 L3_bact: 50S ribosomal protein uL3 5 208 2.9E-83 T 13-10-2018 IPR019927 Ribosomal protein L3, bacterial/organelle-type GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0753 4cd52b0313f71641c1d82061845a1aab 215 Hamap MF_01325_B 50S ribosomal protein L3 [rplC]. 3 212 36.619 T 13-10-2018 IPR019927 Ribosomal protein L3, bacterial/organelle-type GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0753 4cd52b0313f71641c1d82061845a1aab 215 Pfam PF00297 Ribosomal protein L3 107 185 5.2E-12 T 13-10-2018 IPR000597 Ribosomal protein L3 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0753 4cd52b0313f71641c1d82061845a1aab 215 ProSitePatterns PS00474 Ribosomal protein L3 signature. 106 129 - T 13-10-2018 IPR019926 Ribosomal protein L3, conserved site TOPB45_1344 96895d9f546da04c142cc54199316f86 713 Gene3D G3DSA:3.40.50.2000 58 147 3.0E-12 T 13-10-2018 TOPB45_1344 96895d9f546da04c142cc54199316f86 713 SUPERFAMILY SSF53756 64 363 2.67E-33 T 13-10-2018 TOPB45_1344 96895d9f546da04c142cc54199316f86 713 Gene3D G3DSA:3.40.50.150 433 628 9.0E-31 T 13-10-2018 TOPB45_1344 96895d9f546da04c142cc54199316f86 713 Pfam PF13489 Methyltransferase domain 470 619 3.7E-18 T 13-10-2018 TOPB45_1344 96895d9f546da04c142cc54199316f86 713 Gene3D G3DSA:3.40.50.2000 180 364 5.0E-8 T 13-10-2018 TOPB45_1344 96895d9f546da04c142cc54199316f86 713 SUPERFAMILY SSF53335 463 629 7.17E-32 T 13-10-2018 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TOPB45_0679 f820a975a472ae803d5aea5f8ba9a170 132 Pfam PF02472 Biopolymer transport protein ExbD/TolR 5 131 9.2E-29 T 13-10-2018 IPR003400 Biopolymer transport protein ExbD/TolR GO:0022857|GO:0055085 TOPB45_0679 f820a975a472ae803d5aea5f8ba9a170 132 Gene3D G3DSA:3.30.420.270 57 126 7.9E-11 T 13-10-2018 TOPB45_0226 5bbae7373c63cd90e9e2d10b2498d26b 370 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion 64 286 2.2E-16 T 13-10-2018 IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain TOPB45_0226 5bbae7373c63cd90e9e2d10b2498d26b 370 TIGRFAM TIGR01730 RND_mfp: efflux transporter, RND family, MFP subunit 41 364 4.8E-74 T 13-10-2018 IPR006143 RND efflux pump, membrane fusion protein GO:0005215|GO:0016020|GO:0055085 TOPB45_0226 5bbae7373c63cd90e9e2d10b2498d26b 370 Gene3D G3DSA:2.40.50.100 65 207 4.8E-76 T 13-10-2018 TOPB45_0226 5bbae7373c63cd90e9e2d10b2498d26b 370 Gene3D G3DSA:1.10.287.470 100 173 4.8E-76 T 13-10-2018 TOPB45_0226 5bbae7373c63cd90e9e2d10b2498d26b 370 Gene3D G3DSA:2.40.420.20 295 362 4.8E-76 T 13-10-2018 TOPB45_0226 5bbae7373c63cd90e9e2d10b2498d26b 370 Gene3D G3DSA:2.40.30.170 54 294 4.8E-76 T 13-10-2018 TOPB45_0226 5bbae7373c63cd90e9e2d10b2498d26b 370 SUPERFAMILY SSF111369 54 291 2.75E-47 T 13-10-2018 TOPB45_0500 4df3aa9cde09a71951b6c3add2ea3b4d 643 SMART SM00852 177 318 6.9E-28 T 13-10-2018 IPR001453 MoaB/Mog domain TOPB45_0500 4df3aa9cde09a71951b6c3add2ea3b4d 643 SUPERFAMILY SSF53218 175 321 6.28E-32 T 13-10-2018 IPR036425 MoaB/Mog-like domain superfamily TOPB45_0500 4df3aa9cde09a71951b6c3add2ea3b4d 643 Gene3D G3DSA:3.90.105.10 36 171 3.0E-79 T 13-10-2018 TOPB45_0500 4df3aa9cde09a71951b6c3add2ea3b4d 643 Pfam PF03453 MoeA N-terminal region (domain I and II) 11 164 1.0E-35 T 13-10-2018 IPR005110 MoeA, N-terminal and linker domain GO:0032324 KEGG: 00790+2.10.1.1|MetaCyc: PWY-6823|Reactome: R-HSA-947581 TOPB45_0500 4df3aa9cde09a71951b6c3add2ea3b4d 643 Gene3D G3DSA:2.170.190.11 57 138 3.0E-79 T 13-10-2018 TOPB45_0500 4df3aa9cde09a71951b6c3add2ea3b4d 643 SUPERFAMILY SSF63882 16 172 2.49E-41 T 13-10-2018 IPR036135 MoeA, N-terminal and linker domain superfamily GO:0032324 KEGG: 00790+2.10.1.1|MetaCyc: PWY-6823|Reactome: R-HSA-947581 TOPB45_0500 4df3aa9cde09a71951b6c3add2ea3b4d 643 Pfam PF03454 MoeA C-terminal region (domain IV) 331 401 7.9E-16 T 13-10-2018 IPR005111 MoeA, C-terminal, domain IV GO:0032324 KEGG: 00790+2.10.1.1|MetaCyc: PWY-6823|Reactome: R-HSA-947581 TOPB45_0500 4df3aa9cde09a71951b6c3add2ea3b4d 643 SUPERFAMILY SSF53850 415 619 4.94E-19 T 13-10-2018 TOPB45_0500 4df3aa9cde09a71951b6c3add2ea3b4d 643 Gene3D G3DSA:3.40.980.10 172 316 3.0E-79 T 13-10-2018 IPR036425 MoaB/Mog-like domain superfamily TOPB45_0500 4df3aa9cde09a71951b6c3add2ea3b4d 643 Gene3D G3DSA:3.40.190.10 494 592 1.5E-8 T 13-10-2018 TOPB45_0500 4df3aa9cde09a71951b6c3add2ea3b4d 643 Gene3D G3DSA:2.40.340.10 328 403 1.2E-20 T 13-10-2018 IPR036688 MoeA, C-terminal, domain IV superfamily GO:0032324 KEGG: 00790+2.10.1.1|MetaCyc: PWY-6823|Reactome: R-HSA-947581 TOPB45_0500 4df3aa9cde09a71951b6c3add2ea3b4d 643 Pfam PF00994 Probable molybdopterin binding domain 177 317 2.9E-18 T 13-10-2018 IPR001453 MoaB/Mog domain TOPB45_0500 4df3aa9cde09a71951b6c3add2ea3b4d 643 Pfam PF12727 PBP superfamily domain 428 615 1.4E-70 T 13-10-2018 IPR024370 PBP domain TOPB45_0500 4df3aa9cde09a71951b6c3add2ea3b4d 643 SUPERFAMILY SSF63867 329 401 1.57E-17 T 13-10-2018 IPR036688 MoeA, C-terminal, domain IV superfamily GO:0032324 KEGG: 00790+2.10.1.1|MetaCyc: PWY-6823|Reactome: R-HSA-947581 TOPB45_0128 67f82576991409dd516f00fd46f21fc1 425 SUPERFAMILY SSF54826 3 137 5.83E-55 T 13-10-2018 TOPB45_0128 67f82576991409dd516f00fd46f21fc1 425 Gene3D G3DSA:3.20.20.120 128 425 4.0E-135 T 13-10-2018 IPR036849 Enolase-like, C-terminal domain superfamily TOPB45_0128 67f82576991409dd516f00fd46f21fc1 425 SMART SM01192 139 425 8.0E-206 T 13-10-2018 IPR020810 Enolase, C-terminal TIM barrel domain KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TOPB45_0128 67f82576991409dd516f00fd46f21fc1 425 SMART SM01193 4 134 1.1E-90 T 13-10-2018 IPR020811 Enolase, N-terminal KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TOPB45_0128 67f82576991409dd516f00fd46f21fc1 425 SUPERFAMILY SSF51604 139 423 4.19E-124 T 13-10-2018 IPR036849 Enolase-like, C-terminal domain superfamily TOPB45_0128 67f82576991409dd516f00fd46f21fc1 425 Pfam PF03952 Enolase, N-terminal domain 4 134 1.9E-59 T 13-10-2018 IPR020811 Enolase, N-terminal KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TOPB45_0128 67f82576991409dd516f00fd46f21fc1 425 PRINTS PR00148 Enolase signature 335 349 4.5E-47 T 13-10-2018 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TOPB45_0128 67f82576991409dd516f00fd46f21fc1 425 PRINTS PR00148 Enolase signature 364 381 4.5E-47 T 13-10-2018 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TOPB45_0128 67f82576991409dd516f00fd46f21fc1 425 PRINTS PR00148 Enolase signature 312 323 4.5E-47 T 13-10-2018 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TOPB45_0128 67f82576991409dd516f00fd46f21fc1 425 PRINTS PR00148 Enolase signature 37 51 4.5E-47 T 13-10-2018 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TOPB45_0128 67f82576991409dd516f00fd46f21fc1 425 PRINTS PR00148 Enolase signature 161 174 4.5E-47 T 13-10-2018 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TOPB45_0128 67f82576991409dd516f00fd46f21fc1 425 PRINTS PR00148 Enolase signature 107 123 4.5E-47 T 13-10-2018 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TOPB45_0128 67f82576991409dd516f00fd46f21fc1 425 ProSitePatterns PS00164 Enolase signature. 335 348 - T 13-10-2018 IPR020809 Enolase, conserved site KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_0128 67f82576991409dd516f00fd46f21fc1 425 TIGRFAM TIGR01060 eno: phosphopyruvate hydratase 4 423 2.2E-202 T 13-10-2018 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TOPB45_0128 67f82576991409dd516f00fd46f21fc1 425 PIRSF PIRSF001400 1 425 5.0E-192 T 13-10-2018 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TOPB45_0128 67f82576991409dd516f00fd46f21fc1 425 Gene3D G3DSA:3.30.390.10 1 127 1.3E-56 T 13-10-2018 IPR029017 Enolase-like, N-terminal TOPB45_0128 67f82576991409dd516f00fd46f21fc1 425 Hamap MF_00318 Enolase [eno]. 2 412 44.11 T 13-10-2018 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TOPB45_0128 67f82576991409dd516f00fd46f21fc1 425 Pfam PF00113 Enolase, C-terminal TIM barrel domain 140 424 1.8E-129 T 13-10-2018 IPR020810 Enolase, C-terminal TIM barrel domain KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TOPB45_1114 8dc5710c5d9f33d09d1c06d206050cc1 283 Gene3D G3DSA:3.30.70.1900 127 261 4.3E-31 T 13-10-2018 TOPB45_1114 8dc5710c5d9f33d09d1c06d206050cc1 283 Gene3D G3DSA:3.30.70.1890 1 121 1.1E-5 T 13-10-2018 TOPB45_1114 8dc5710c5d9f33d09d1c06d206050cc1 283 Pfam PF10040 CRISPR-associated endoribonuclease Cas6 144 257 5.7E-17 T 13-10-2018 IPR019267 CRISPR-associated protein Cas6, C-terminal TOPB45_0488 66cf873b7caabf74e0069755bd2c814b 187 Pfam PF01569 PAP2 superfamily 55 179 1.1E-19 T 13-10-2018 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase TOPB45_0488 66cf873b7caabf74e0069755bd2c814b 187 SUPERFAMILY SSF48317 3 182 1.01E-32 T 13-10-2018 IPR036938 Phosphatidic acid phosphatase type 2/haloperoxidase superfamily TOPB45_0488 66cf873b7caabf74e0069755bd2c814b 187 SMART SM00014 57 177 3.1E-21 T 13-10-2018 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase TOPB45_0488 66cf873b7caabf74e0069755bd2c814b 187 Gene3D G3DSA:1.20.144.10 4 187 3.4E-24 T 13-10-2018 TOPB45_0302 54fd78aad39496c59e5f583e0e16bf0f 378 Pfam PF01546 Peptidase family M20/M25/M40 74 372 5.7E-17 T 13-10-2018 IPR002933 Peptidase M20 GO:0016787 TOPB45_0302 54fd78aad39496c59e5f583e0e16bf0f 378 TIGRFAM TIGR01883 PepT-like: peptidase T-like protein 7 371 8.5E-91 T 13-10-2018 IPR010162 Peptidase M20B, peptidase T-like TOPB45_0302 54fd78aad39496c59e5f583e0e16bf0f 378 PIRSF PIRSF001123 87 176 1.5E-4 T 13-10-2018 IPR008007 Peptidase M42 TOPB45_0302 54fd78aad39496c59e5f583e0e16bf0f 378 PIRSF PIRSF001123 5 83 0.086 T 13-10-2018 IPR008007 Peptidase M42 TOPB45_0302 54fd78aad39496c59e5f583e0e16bf0f 378 PIRSF PIRSF001123 291 377 1.5E-4 T 13-10-2018 IPR008007 Peptidase M42 TOPB45_0302 54fd78aad39496c59e5f583e0e16bf0f 378 SUPERFAMILY SSF53187 10 372 7.04E-54 T 13-10-2018 TOPB45_0302 54fd78aad39496c59e5f583e0e16bf0f 378 Gene3D G3DSA:3.30.70.360 175 292 2.4E-117 T 13-10-2018 TOPB45_0302 54fd78aad39496c59e5f583e0e16bf0f 378 SUPERFAMILY SSF55031 178 270 5.63E-20 T 13-10-2018 IPR036264 Bacterial exopeptidase dimerisation domain TOPB45_0302 54fd78aad39496c59e5f583e0e16bf0f 378 Pfam PF07687 Peptidase dimerisation domain 179 270 1.2E-19 T 13-10-2018 IPR011650 Peptidase M20, dimerisation domain TOPB45_0302 54fd78aad39496c59e5f583e0e16bf0f 378 Gene3D G3DSA:3.40.630.10 14 367 2.4E-117 T 13-10-2018 TOPB45_0838 c80299e3409efdeb779e3a31d87d6048 489 SMART SM01240 7 474 0.0 T 13-10-2018 TOPB45_0838 c80299e3409efdeb779e3a31d87d6048 489 Pfam PF00571 CBS domain 93 141 4.7E-12 T 13-10-2018 IPR000644 CBS domain TOPB45_0838 c80299e3409efdeb779e3a31d87d6048 489 Pfam PF00571 CBS domain 150 201 5.8E-7 T 13-10-2018 IPR000644 CBS domain TOPB45_0838 c80299e3409efdeb779e3a31d87d6048 489 Pfam PF00478 IMP dehydrogenase / GMP reductase domain 8 474 1.6E-166 T 13-10-2018 IPR001093 IMP dehydrogenase/GMP reductase GO:0003824|GO:0055114 TOPB45_0838 c80299e3409efdeb779e3a31d87d6048 489 ProSitePatterns PS00487 IMP dehydrogenase / GMP reductase signature. 295 307 - T 13-10-2018 IPR015875 IMP dehydrogenase / GMP reductase, conserved site GO:0016491|GO:0055114 TOPB45_0838 c80299e3409efdeb779e3a31d87d6048 489 TIGRFAM TIGR01302 IMP_dehydrog: inosine-5'-monophosphate dehydrogenase 8 455 8.0E-197 T 13-10-2018 IPR005990 Inosine-5'-monophosphate dehydrogenase GO:0003938|GO:0006164|GO:0055114 KEGG: 00230+1.1.1.205|KEGG: 00983+1.1.1.205|MetaCyc: PWY-5695|MetaCyc: PWY-6596|MetaCyc: PWY-7221|Reactome: R-HSA-6798695|Reactome: R-HSA-73817 TOPB45_0838 c80299e3409efdeb779e3a31d87d6048 489 SUPERFAMILY SSF51412 4 478 4.58E-125 T 13-10-2018 TOPB45_0838 c80299e3409efdeb779e3a31d87d6048 489 SUPERFAMILY SSF54631 65 203 1.19E-32 T 13-10-2018 TOPB45_0838 c80299e3409efdeb779e3a31d87d6048 489 Hamap MF_01964 Inosine-5'-monophosphate dehydrogenase [guaB]. 8 487 84.126 T 13-10-2018 IPR005990 Inosine-5'-monophosphate dehydrogenase GO:0003938|GO:0006164|GO:0055114 KEGG: 00230+1.1.1.205|KEGG: 00983+1.1.1.205|MetaCyc: PWY-5695|MetaCyc: PWY-6596|MetaCyc: PWY-7221|Reactome: R-HSA-6798695|Reactome: R-HSA-73817 TOPB45_0838 c80299e3409efdeb779e3a31d87d6048 489 Gene3D G3DSA:3.20.20.70 2 487 3.6E-222 T 13-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 TOPB45_0838 c80299e3409efdeb779e3a31d87d6048 489 PIRSF PIRSF000130 1 488 1.5E-212 T 13-10-2018 IPR005990 Inosine-5'-monophosphate dehydrogenase GO:0003938|GO:0006164|GO:0055114 KEGG: 00230+1.1.1.205|KEGG: 00983+1.1.1.205|MetaCyc: PWY-5695|MetaCyc: PWY-6596|MetaCyc: PWY-7221|Reactome: R-HSA-6798695|Reactome: R-HSA-73817 TOPB45_0838 c80299e3409efdeb779e3a31d87d6048 489 SMART SM00116 158 206 1.8E-4 T 13-10-2018 IPR000644 CBS domain TOPB45_0838 c80299e3409efdeb779e3a31d87d6048 489 SMART SM00116 96 145 1.9E-11 T 13-10-2018 IPR000644 CBS domain TOPB45_0576 28aee9af70f2829cbe6f7f56fcb4a39a 209 TIGRFAM TIGR00084 ruvA: Holliday junction DNA helicase RuvA 1 197 2.9E-37 T 13-10-2018 IPR000085 Bacterial DNA recombination protein RuvA GO:0003678|GO:0006281|GO:0006310 TOPB45_0576 28aee9af70f2829cbe6f7f56fcb4a39a 209 Pfam PF07499 RuvA, C-terminal domain 155 197 1.2E-6 T 13-10-2018 IPR011114 Holliday junction DNA helicase RuvA, C-terminal GO:0005524|GO:0006281|GO:0006310|GO:0009378|GO:0009379 TOPB45_0576 28aee9af70f2829cbe6f7f56fcb4a39a 209 SMART SM00278 113 132 0.0012 T 13-10-2018 IPR003583 Helix-hairpin-helix DNA-binding motif, class 1 GO:0003677|GO:0006281 TOPB45_0576 28aee9af70f2829cbe6f7f56fcb4a39a 209 SMART SM00278 78 97 100.0 T 13-10-2018 IPR003583 Helix-hairpin-helix DNA-binding motif, class 1 GO:0003677|GO:0006281 TOPB45_0576 28aee9af70f2829cbe6f7f56fcb4a39a 209 Hamap MF_00031 Holliday junction ATP-dependent DNA helicase RuvA [ruvA]. 1 198 24.023 T 13-10-2018 IPR000085 Bacterial DNA recombination protein RuvA GO:0003678|GO:0006281|GO:0006310 TOPB45_0576 28aee9af70f2829cbe6f7f56fcb4a39a 209 SUPERFAMILY SSF47781 70 138 9.64E-18 T 13-10-2018 IPR010994 RuvA domain 2-like TOPB45_0576 28aee9af70f2829cbe6f7f56fcb4a39a 209 Pfam PF14520 Helix-hairpin-helix domain 77 134 2.8E-14 T 13-10-2018 TOPB45_0576 28aee9af70f2829cbe6f7f56fcb4a39a 209 SUPERFAMILY SSF46929 154 196 3.27E-7 T 13-10-2018 IPR036267 RuvA, C-terminal domain superfamily TOPB45_0576 28aee9af70f2829cbe6f7f56fcb4a39a 209 Gene3D G3DSA:1.10.8.10 153 197 3.8E-7 T 13-10-2018 TOPB45_0576 28aee9af70f2829cbe6f7f56fcb4a39a 209 Gene3D G3DSA:1.10.150.20 72 137 3.1E-20 T 13-10-2018 TOPB45_0555 d4548d2a337afc6e101b8d7049cfc26b 250 Gene3D G3DSA:3.60.15.10 2 250 9.7E-30 T 13-10-2018 IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like TOPB45_0555 d4548d2a337afc6e101b8d7049cfc26b 250 SUPERFAMILY SSF56281 3 250 8.38E-37 T 13-10-2018 IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like TOPB45_0555 d4548d2a337afc6e101b8d7049cfc26b 250 Pfam PF12706 Beta-lactamase superfamily domain 35 215 6.2E-16 T 13-10-2018 IPR001279 Metallo-beta-lactamase TOPB45_0564 c22d2381a4c7c72d495982f8267a4007 341 Pfam PF04613 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD 21 88 1.1E-12 T 13-10-2018 IPR020573 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, non-repeat region GO:0009245|GO:0016747 TOPB45_0564 c22d2381a4c7c72d495982f8267a4007 341 Gene3D G3DSA:2.160.10.10 100 312 1.9E-59 T 13-10-2018 TOPB45_0564 c22d2381a4c7c72d495982f8267a4007 341 SUPERFAMILY SSF51161 32 318 2.75E-68 T 13-10-2018 IPR011004 Trimeric LpxA-like superfamily TOPB45_0564 c22d2381a4c7c72d495982f8267a4007 341 Gene3D G3DSA:3.40.1390.10 1 97 4.5E-16 T 13-10-2018 TOPB45_0564 c22d2381a4c7c72d495982f8267a4007 341 Pfam PF00132 Bacterial transferase hexapeptide (six repeats) 227 261 4.9E-5 T 13-10-2018 IPR001451 Hexapeptide repeat TOPB45_0564 c22d2381a4c7c72d495982f8267a4007 341 Pfam PF00132 Bacterial transferase hexapeptide (six repeats) 147 179 1.5E-10 T 13-10-2018 IPR001451 Hexapeptide repeat TOPB45_0564 c22d2381a4c7c72d495982f8267a4007 341 Pfam PF00132 Bacterial transferase hexapeptide (six repeats) 110 143 2.1E-5 T 13-10-2018 IPR001451 Hexapeptide repeat TOPB45_0564 c22d2381a4c7c72d495982f8267a4007 341 Hamap MF_00523 UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase [lpxD]. 9 329 30.638 T 13-10-2018 IPR007691 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase LpxD GO:0009245|GO:0016410 TOPB45_0564 c22d2381a4c7c72d495982f8267a4007 341 ProSitePatterns PS00101 Hexapeptide-repeat containing-transferases signature. 130 158 - T 13-10-2018 IPR018357 Hexapeptide transferase, conserved site GO:0016740 Reactome: R-HSA-446205 TOPB45_0564 c22d2381a4c7c72d495982f8267a4007 341 TIGRFAM TIGR01853 lipid_A_lpxD: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase LpxD 10 331 2.0E-96 T 13-10-2018 IPR007691 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase LpxD GO:0009245|GO:0016410 TOPB45_0564 c22d2381a4c7c72d495982f8267a4007 341 Pfam PF14602 Hexapeptide repeat of succinyl-transferase 204 221 0.15 T 13-10-2018 IPR001451 Hexapeptide repeat TOPB45_0737 9719ac645f9a3106c2e0ec28f1edd040 256 Pfam PF10411 Disulfide bond isomerase protein N-terminus 41 98 4.2E-15 T 13-10-2018 IPR018950 Disulphide bond isomerase, DsbC/G, N-terminal TOPB45_0737 9719ac645f9a3106c2e0ec28f1edd040 256 SUPERFAMILY SSF54423 44 101 4.12E-8 T 13-10-2018 IPR009094 Disulphide bond isomerase DsbC/G, N-terminal domain superfamily GO:0042597 TOPB45_0737 9719ac645f9a3106c2e0ec28f1edd040 256 Gene3D G3DSA:3.40.30.10 101 256 2.6E-26 T 13-10-2018 TOPB45_0737 9719ac645f9a3106c2e0ec28f1edd040 256 Pfam PF13098 Thioredoxin-like domain 132 247 3.7E-14 T 13-10-2018 IPR012336 Thioredoxin-like fold TOPB45_0737 9719ac645f9a3106c2e0ec28f1edd040 256 SUPERFAMILY SSF52833 123 255 1.68E-22 T 13-10-2018 IPR036249 Thioredoxin-like superfamily TOPB45_0737 9719ac645f9a3106c2e0ec28f1edd040 256 Gene3D G3DSA:3.10.450.70 35 100 1.1E-8 T 13-10-2018 IPR009094 Disulphide bond isomerase DsbC/G, N-terminal domain superfamily GO:0042597 TOPB45_0764 bfd38d8259c61d1af6ef3c242ebe63e6 122 SUPERFAMILY SSF50104 16 117 1.81E-38 T 13-10-2018 IPR008991 Translation protein SH3-like domain superfamily TOPB45_0764 bfd38d8259c61d1af6ef3c242ebe63e6 122 Hamap MF_01326_B 50S ribosomal protein L24 [rplX]. 18 112 21.923 T 13-10-2018 IPR003256 Ribosomal protein L24 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0764 bfd38d8259c61d1af6ef3c242ebe63e6 122 TIGRFAM TIGR01079 rplX_bact: ribosomal protein uL24 18 118 1.4E-38 T 13-10-2018 IPR003256 Ribosomal protein L24 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0764 bfd38d8259c61d1af6ef3c242ebe63e6 122 ProSitePatterns PS01108 Ribosomal protein L24 signature. 23 40 - T 13-10-2018 IPR005825 Ribosomal protein L24/L26, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0764 bfd38d8259c61d1af6ef3c242ebe63e6 122 Pfam PF17136 Ribosomal proteins 50S L24/mitochondrial 39S L24 55 118 2.9E-28 T 13-10-2018 IPR003256 Ribosomal protein L24 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0764 bfd38d8259c61d1af6ef3c242ebe63e6 122 Gene3D G3DSA:2.30.30.30 10 117 4.7E-43 T 13-10-2018 IPR014722 Ribosomal protein L2, domain 2 TOPB45_0764 bfd38d8259c61d1af6ef3c242ebe63e6 122 SMART SM00739 19 46 1.6E-6 T 13-10-2018 IPR005824 KOW TOPB45_0764 bfd38d8259c61d1af6ef3c242ebe63e6 122 Pfam PF00467 KOW motif 22 53 8.5E-8 T 13-10-2018 IPR005824 KOW TOPB45_0024 a00aa7a540b632fd71fbdcd666f04afa 387 Pfam PF00266 Aminotransferase class-V 8 329 2.2E-42 T 13-10-2018 IPR000192 Aminotransferase class V domain TOPB45_0024 a00aa7a540b632fd71fbdcd666f04afa 387 Gene3D G3DSA:3.40.640.10 18 260 2.0E-130 T 13-10-2018 IPR015421 Pyridoxal phosphate-dependent transferase, major domain GO:0003824 TOPB45_0024 a00aa7a540b632fd71fbdcd666f04afa 387 PIRSF PIRSF000524 2 385 6.9E-133 T 13-10-2018 IPR024169 Serine-pyruvate aminotransferase/2-aminoethylphosphonate-pyruvate transaminase KEGG: 00440+2.6.1.37|MetaCyc: PWY-6832|Reactome: R-HSA-389661|Reactome: R-HSA-9033241 TOPB45_0024 a00aa7a540b632fd71fbdcd666f04afa 387 ProSitePatterns PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 184 204 - T 13-10-2018 IPR020578 Aminotransferase class-V, pyridoxal-phosphate binding site TOPB45_0024 a00aa7a540b632fd71fbdcd666f04afa 387 Gene3D G3DSA:3.90.1150.10 13 372 2.0E-130 T 13-10-2018 IPR015422 Pyridoxal phosphate-dependent transferase domain 1 GO:0003824 TOPB45_0024 a00aa7a540b632fd71fbdcd666f04afa 387 SUPERFAMILY SSF53383 5 363 3.63E-98 T 13-10-2018 IPR015424 Pyridoxal phosphate-dependent transferase TOPB45_1164 a925c542e484769425a53370fbec3326 187 Gene3D G3DSA:3.40.50.1000 4 183 9.6E-56 T 13-10-2018 IPR023214 HAD superfamily TOPB45_1164 a925c542e484769425a53370fbec3326 187 PIRSF PIRSF004682 1 175 1.6E-56 T 13-10-2018 IPR004446 D,D-heptose 1,7-bisphosphate phosphatase GO:0005975|GO:0016791 TOPB45_1164 a925c542e484769425a53370fbec3326 187 Pfam PF13242 HAD-hyrolase-like 100 173 8.0E-15 T 13-10-2018 TOPB45_1164 a925c542e484769425a53370fbec3326 187 TIGRFAM TIGR01662 HAD-SF-IIIA: HAD hydrolase, family IIIA 5 147 1.6E-32 T 13-10-2018 IPR006549 HAD-superfamily hydrolase,subfamily IIIA Reactome: R-HSA-5649702 TOPB45_1164 a925c542e484769425a53370fbec3326 187 TIGRFAM TIGR01656 Histidinol-ppas: histidinol-phosphate phosphatase domain 4 143 6.6E-45 T 13-10-2018 IPR006543 Histidinol-phosphate phosphatase GO:0016791 TOPB45_1164 a925c542e484769425a53370fbec3326 187 SUPERFAMILY SSF56784 2 179 5.65E-48 T 13-10-2018 IPR036412 HAD-like superfamily TOPB45_0168 372b1bf347d4276d05520960bdb16f8f 141 Hamap MF_00736 50S ribosomal protein L11 [rplK]. 5 141 31.865 T 13-10-2018 IPR000911 Ribosomal protein L11/L12 GO:0003735|GO:0005840|GO:0006412 TOPB45_0168 372b1bf347d4276d05520960bdb16f8f 141 Gene3D G3DSA:3.30.1550.10 2 71 3.0E-34 T 13-10-2018 IPR036796 Ribosomal protein L11/L12, N-terminal domain superfamily TOPB45_0168 372b1bf347d4276d05520960bdb16f8f 141 Gene3D G3DSA:1.10.10.2720 72 141 1.9E-30 T 13-10-2018 TOPB45_0168 372b1bf347d4276d05520960bdb16f8f 141 TIGRFAM TIGR01632 L11_bact: ribosomal protein uL11 3 141 3.9E-66 T 13-10-2018 IPR006519 Ribosomal protein L11, bacterial-type GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0168 372b1bf347d4276d05520960bdb16f8f 141 SMART SM00649 9 140 5.3E-86 T 13-10-2018 IPR000911 Ribosomal protein L11/L12 GO:0003735|GO:0005840|GO:0006412 TOPB45_0168 372b1bf347d4276d05520960bdb16f8f 141 ProDom PD001367 RIBOSOMAL RIBONUCLEOPROTEIN L11 RRNA-BINDING RNA-BINDING METHYLATION 50S L11 BACTERIAL CHLOROPLAST 36 73 2.0E-11 T 13-10-2018 TOPB45_0168 372b1bf347d4276d05520960bdb16f8f 141 Pfam PF00298 Ribosomal protein L11, RNA binding domain 71 139 5.1E-26 T 13-10-2018 IPR020783 Ribosomal protein L11, C-terminal GO:0003735|GO:0005840|GO:0006412 TOPB45_0168 372b1bf347d4276d05520960bdb16f8f 141 SUPERFAMILY SSF54747 1 84 3.79E-30 T 13-10-2018 IPR036796 Ribosomal protein L11/L12, N-terminal domain superfamily TOPB45_0168 372b1bf347d4276d05520960bdb16f8f 141 Pfam PF03946 Ribosomal protein L11, N-terminal domain 9 66 4.5E-30 T 13-10-2018 IPR020784 Ribosomal protein L11, N-terminal TOPB45_0168 372b1bf347d4276d05520960bdb16f8f 141 SUPERFAMILY SSF46906 67 139 3.4E-27 T 13-10-2018 IPR036769 Ribosomal protein L11, C-terminal domain superfamily TOPB45_0168 372b1bf347d4276d05520960bdb16f8f 141 ProSitePatterns PS00359 Ribosomal protein L11 signature. 126 141 - T 13-10-2018 IPR020785 Ribosomal protein L11, conserved site GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0717 15eadb107cf910d28e39747d70cac04d 344 Pfam PF01118 Semialdehyde dehydrogenase, NAD binding domain 3 142 7.2E-34 T 13-10-2018 IPR000534 Semialdehyde dehydrogenase, NAD-binding GO:0016620|GO:0051287|GO:0055114 TOPB45_0717 15eadb107cf910d28e39747d70cac04d 344 SMART SM00859 3 142 9.5E-46 T 13-10-2018 IPR000534 Semialdehyde dehydrogenase, NAD-binding GO:0016620|GO:0051287|GO:0055114 TOPB45_0717 15eadb107cf910d28e39747d70cac04d 344 Pfam PF02774 Semialdehyde dehydrogenase, dimerisation domain 159 315 2.2E-20 T 13-10-2018 IPR012280 Semialdehyde dehydrogenase, dimerisation domain GO:0005737|GO:0008652|GO:0016620|GO:0046983 KEGG: 00220+1.2.1.38|MetaCyc: PWY-5154|MetaCyc: PWY-7400 TOPB45_0717 15eadb107cf910d28e39747d70cac04d 344 Gene3D G3DSA:3.40.50.720 3 330 2.2E-125 T 13-10-2018 TOPB45_0717 15eadb107cf910d28e39747d70cac04d 344 TIGRFAM TIGR01850 argC: N-acetyl-gamma-glutamyl-phosphate reductase 2 343 4.3E-128 T 13-10-2018 IPR000706 N-acetyl-gamma-glutamyl-phosphate reductase, type 1 GO:0003942|GO:0006526|GO:0055114 KEGG: 00220+1.2.1.38|MetaCyc: PWY-5154|MetaCyc: PWY-7400 TOPB45_0717 15eadb107cf910d28e39747d70cac04d 344 SUPERFAMILY SSF55347 150 312 6.28E-50 T 13-10-2018 TOPB45_0717 15eadb107cf910d28e39747d70cac04d 344 ProSitePatterns PS01224 N-acetyl-gamma-glutamyl-phosphate reductase active site. 145 161 - T 13-10-2018 IPR023013 N-acetyl-gamma-glutamyl-phosphate reductase, active site GO:0003942|GO:0055114 KEGG: 00220+1.2.1.38|MetaCyc: PWY-5154|MetaCyc: PWY-7400 TOPB45_0717 15eadb107cf910d28e39747d70cac04d 344 SUPERFAMILY SSF51735 2 175 9.64E-52 T 13-10-2018 IPR036291 NAD(P)-binding domain superfamily TOPB45_0717 15eadb107cf910d28e39747d70cac04d 344 Gene3D G3DSA:3.30.360.10 148 312 2.2E-125 T 13-10-2018 TOPB45_0717 15eadb107cf910d28e39747d70cac04d 344 Hamap MF_00150 N-acetyl-gamma-glutamyl-phosphate reductase [argC]. 2 338 41.071 T 13-10-2018 IPR000706 N-acetyl-gamma-glutamyl-phosphate reductase, type 1 GO:0003942|GO:0006526|GO:0055114 KEGG: 00220+1.2.1.38|MetaCyc: PWY-5154|MetaCyc: PWY-7400 TOPB45_1002 b9163cbf6b3fb6913f8916d02284ef93 376 Pfam PF01041 DegT/DnrJ/EryC1/StrS aminotransferase family 17 370 4.3E-103 T 13-10-2018 IPR000653 DegT/DnrJ/EryC1/StrS aminotransferase TOPB45_1002 b9163cbf6b3fb6913f8916d02284ef93 376 Gene3D G3DSA:3.90.1150.10 253 376 1.3E-41 T 13-10-2018 IPR015422 Pyridoxal phosphate-dependent transferase domain 1 GO:0003824 TOPB45_1002 b9163cbf6b3fb6913f8916d02284ef93 376 PIRSF PIRSF000390 1 376 5.0E-100 T 13-10-2018 IPR000653 DegT/DnrJ/EryC1/StrS aminotransferase TOPB45_1002 b9163cbf6b3fb6913f8916d02284ef93 376 Gene3D G3DSA:3.40.640.10 1 250 3.2E-76 T 13-10-2018 IPR015421 Pyridoxal phosphate-dependent transferase, major domain GO:0003824 TOPB45_1002 b9163cbf6b3fb6913f8916d02284ef93 376 SUPERFAMILY SSF53383 13 376 3.99E-109 T 13-10-2018 IPR015424 Pyridoxal phosphate-dependent transferase TOPB45_1192 69d7dd678bc9048ca43a72fa032c2149 187 Pfam PF08207 Elongation factor P (EF-P) KOW-like domain 4 61 7.9E-23 T 13-10-2018 IPR013185 Translation elongation factor, KOW-like TOPB45_1192 69d7dd678bc9048ca43a72fa032c2149 187 SMART SM01185 68 122 6.9E-25 T 13-10-2018 IPR001059 Translation elongation factor P/YeiP, central GO:0003746|GO:0006414 TOPB45_1192 69d7dd678bc9048ca43a72fa032c2149 187 Hamap MF_00141 Elongation factor P [efp]. 2 186 47.903 T 13-10-2018 IPR011768 Translation elongation factor P GO:0003746|GO:0005737|GO:0006414 TOPB45_1192 69d7dd678bc9048ca43a72fa032c2149 187 ProSitePatterns PS01275 Elongation factor P signature. 151 170 - T 13-10-2018 IPR013852 Translation elongation factor P/YeiP, conserved site TOPB45_1192 69d7dd678bc9048ca43a72fa032c2149 187 SUPERFAMILY SSF50249 67 127 7.28E-19 T 13-10-2018 IPR012340 Nucleic acid-binding, OB-fold TOPB45_1192 69d7dd678bc9048ca43a72fa032c2149 187 SUPERFAMILY SSF50104 3 63 2.95E-16 T 13-10-2018 IPR008991 Translation protein SH3-like domain superfamily TOPB45_1192 69d7dd678bc9048ca43a72fa032c2149 187 Gene3D G3DSA:2.40.50.140 66 128 5.9E-25 T 13-10-2018 TOPB45_1192 69d7dd678bc9048ca43a72fa032c2149 187 Gene3D G3DSA:2.40.50.140 129 186 6.6E-30 T 13-10-2018 TOPB45_1192 69d7dd678bc9048ca43a72fa032c2149 187 Pfam PF09285 Elongation factor P, C-terminal 130 185 1.6E-28 T 13-10-2018 IPR015365 Elongation factor P, C-terminal GO:0005737|GO:0043043 TOPB45_1192 69d7dd678bc9048ca43a72fa032c2149 187 SUPERFAMILY SSF50249 130 186 2.48E-20 T 13-10-2018 IPR012340 Nucleic acid-binding, OB-fold TOPB45_1192 69d7dd678bc9048ca43a72fa032c2149 187 Gene3D G3DSA:2.30.30.30 1 63 1.6E-23 T 13-10-2018 IPR014722 Ribosomal protein L2, domain 2 TOPB45_1192 69d7dd678bc9048ca43a72fa032c2149 187 SMART SM00841 130 185 9.7E-36 T 13-10-2018 IPR015365 Elongation factor P, C-terminal GO:0005737|GO:0043043 TOPB45_1192 69d7dd678bc9048ca43a72fa032c2149 187 TIGRFAM TIGR00038 efp: translation elongation factor P 3 186 2.2E-77 T 13-10-2018 IPR011768 Translation elongation factor P GO:0003746|GO:0005737|GO:0006414 TOPB45_1192 69d7dd678bc9048ca43a72fa032c2149 187 Pfam PF01132 Elongation factor P (EF-P) OB domain 69 122 3.7E-22 T 13-10-2018 IPR001059 Translation elongation factor P/YeiP, central GO:0003746|GO:0006414 TOPB45_1192 69d7dd678bc9048ca43a72fa032c2149 187 PIRSF PIRSF005901 1 187 4.2E-70 T 13-10-2018 IPR020599 Translation elongation factor P/YeiP TOPB45_0485 3947e6a570057dcf0b6905933358c88a 105 Gene3D G3DSA:3.30.70.930 1 97 8.2E-28 T 13-10-2018 IPR029756 MTH1187/YkoF-like TOPB45_0485 3947e6a570057dcf0b6905933358c88a 105 TIGRFAM TIGR00106 TIGR00106: uncharacterized protein, MTH1187 family 4 98 3.0E-18 T 13-10-2018 IPR002767 Thiamine-binding protein TOPB45_0485 3947e6a570057dcf0b6905933358c88a 105 SUPERFAMILY SSF89957 1 98 1.02E-25 T 13-10-2018 IPR029756 MTH1187/YkoF-like TOPB45_0485 3947e6a570057dcf0b6905933358c88a 105 Pfam PF01910 Thiamine-binding protein 7 95 6.5E-24 T 13-10-2018 IPR002767 Thiamine-binding protein TOPB45_0572 ef2a8d4a2133ec85f07c5018582c5a78 446 Gene3D G3DSA:3.80.30.20 206 409 2.6E-18 T 13-10-2018 IPR023404 Radical SAM, alpha/beta horseshoe TOPB45_0572 ef2a8d4a2133ec85f07c5018582c5a78 446 Pfam PF04055 Radical SAM superfamily 213 374 3.0E-19 T 13-10-2018 IPR007197 Radical SAM GO:0003824|GO:0051536 TOPB45_0572 ef2a8d4a2133ec85f07c5018582c5a78 446 SMART SM00729 207 416 4.9E-24 T 13-10-2018 IPR006638 Elp3/MiaB/NifB GO:0003824|GO:0051536 TOPB45_0572 ef2a8d4a2133ec85f07c5018582c5a78 446 SUPERFAMILY SSF102114 160 409 2.35E-30 T 13-10-2018 TOPB45_0676 3dd07f11e41d842690b050dfe849bd55 96 Pfam PF01312 FlhB HrpN YscU SpaS Family 6 78 5.3E-22 T 13-10-2018 IPR006135 Type III secretion system substrate exporter GO:0009306|GO:0016020 TOPB45_0676 3dd07f11e41d842690b050dfe849bd55 96 SUPERFAMILY SSF160544 6 83 2.09E-23 T 13-10-2018 IPR029025 Type III secretion system substrate exporter, C-terminal TOPB45_0676 3dd07f11e41d842690b050dfe849bd55 96 PRINTS PR00950 Type III secretion system inner membrane S protein family signature 6 21 9.7E-6 T 13-10-2018 IPR006135 Type III secretion system substrate exporter GO:0009306|GO:0016020 TOPB45_0676 3dd07f11e41d842690b050dfe849bd55 96 PRINTS PR00950 Type III secretion system inner membrane S protein family signature 35 56 9.7E-6 T 13-10-2018 IPR006135 Type III secretion system substrate exporter GO:0009306|GO:0016020 TOPB45_0676 3dd07f11e41d842690b050dfe849bd55 96 Gene3D G3DSA:3.40.1690.10 5 85 5.2E-27 T 13-10-2018 IPR029025 Type III secretion system substrate exporter, C-terminal TOPB45_0763 0a31590468eb2466ab0b09039c46e623 122 SUPERFAMILY SSF50193 1 122 5.89E-53 T 13-10-2018 IPR036853 Ribosomal protein L14 superfamily GO:0003735|GO:0005840|GO:0006412 TOPB45_0763 0a31590468eb2466ab0b09039c46e623 122 TIGRFAM TIGR01067 rplN_bact: ribosomal protein uL14 1 122 1.1E-58 T 13-10-2018 IPR005745 Ribosomal protein L14P, bacterial-type GO:0003735|GO:0006412|GO:0015934 TOPB45_0763 0a31590468eb2466ab0b09039c46e623 122 SMART SM01374 1 122 1.2E-88 T 13-10-2018 IPR000218 Ribosomal protein L14P GO:0003735|GO:0005840|GO:0006412 TOPB45_0763 0a31590468eb2466ab0b09039c46e623 122 Gene3D G3DSA:2.40.150.20 1 122 3.9E-56 T 13-10-2018 IPR036853 Ribosomal protein L14 superfamily GO:0003735|GO:0005840|GO:0006412 TOPB45_0763 0a31590468eb2466ab0b09039c46e623 122 Hamap MF_01367 50S ribosomal protein L14 [rplN]. 1 122 27.269 T 13-10-2018 IPR000218 Ribosomal protein L14P GO:0003735|GO:0005840|GO:0006412 TOPB45_0763 0a31590468eb2466ab0b09039c46e623 122 ProSitePatterns PS00049 Ribosomal protein L14 signature. 60 86 - T 13-10-2018 IPR019972 Ribosomal protein L14P, conserved site Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0763 0a31590468eb2466ab0b09039c46e623 122 Pfam PF00238 Ribosomal protein L14p/L23e 1 122 3.6E-56 T 13-10-2018 IPR000218 Ribosomal protein L14P GO:0003735|GO:0005840|GO:0006412 TOPB45_0200 a8a8bfc5ebc9e85b6733bdcb6400a55d 476 Gene3D G3DSA:3.90.1860.10 3 476 1.4E-188 T 13-10-2018 IPR036025 tRNA-splicing ligase RtcB-like superfamily GO:0006396|GO:0008452 Reactome: R-HSA-6784531 TOPB45_0200 a8a8bfc5ebc9e85b6733bdcb6400a55d 476 ProSitePatterns PS01288 Uncharacterized protein family UPF0027 signature. 45 74 - T 13-10-2018 IPR001233 tRNA-splicing ligase, RtcB GO:0006396|GO:0008452 Reactome: R-HSA-6784531 TOPB45_0200 a8a8bfc5ebc9e85b6733bdcb6400a55d 476 SUPERFAMILY SSF103365 5 476 1.44E-163 T 13-10-2018 IPR036025 tRNA-splicing ligase RtcB-like superfamily GO:0006396|GO:0008452 Reactome: R-HSA-6784531 TOPB45_0200 a8a8bfc5ebc9e85b6733bdcb6400a55d 476 Pfam PF01139 tRNA-splicing ligase RtcB 45 476 7.6E-157 T 13-10-2018 IPR001233 tRNA-splicing ligase, RtcB GO:0006396|GO:0008452 Reactome: R-HSA-6784531 TOPB45_0729 3fb78f278f6d4da593d33cdc1678edc9 452 PIRSF PIRSF006060 8 448 5.4E-77 T 13-10-2018 IPR002293 Amino acid/polyamine transporter I GO:0016020|GO:0022857|GO:0055085 TOPB45_0729 3fb78f278f6d4da593d33cdc1678edc9 452 Gene3D G3DSA:1.20.1740.10 28 451 1.2E-95 T 13-10-2018 TOPB45_0729 3fb78f278f6d4da593d33cdc1678edc9 452 Pfam PF13520 Amino acid permease 31 423 2.3E-53 T 13-10-2018 IPR002293 Amino acid/polyamine transporter I GO:0016020|GO:0022857|GO:0055085 TOPB45_0924 72ff5d8519ca21fbca79a16e3c7c4f45 262 Gene3D G3DSA:1.25.40.10 135 262 3.6E-16 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_0924 72ff5d8519ca21fbca79a16e3c7c4f45 262 SUPERFAMILY SSF48452 152 243 5.01E-14 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_0924 72ff5d8519ca21fbca79a16e3c7c4f45 262 Pfam PF14559 Tetratricopeptide repeat 195 258 1.3E-7 T 13-10-2018 TOPB45_0924 72ff5d8519ca21fbca79a16e3c7c4f45 262 SMART SM00028 185 218 0.0094 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_0586 3113d52dc2a3bd90c8225807cef47dfc 262 Gene3D G3DSA:3.20.20.70 3 262 6.2E-91 T 13-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 TOPB45_0586 3113d52dc2a3bd90c8225807cef47dfc 262 SUPERFAMILY SSF51366 6 258 1.65E-76 T 13-10-2018 IPR011060 Ribulose-phosphate binding barrel GO:0003824 TOPB45_0586 3113d52dc2a3bd90c8225807cef47dfc 262 Hamap MF_00134_B Indole-3-glycerol phosphate synthase [trpC]. 8 259 32.39 T 13-10-2018 IPR013798 Indole-3-glycerol phosphate synthase GO:0004425 KEGG: 00400+4.1.1.48 TOPB45_0586 3113d52dc2a3bd90c8225807cef47dfc 262 Pfam PF00218 Indole-3-glycerol phosphate synthase 36 256 3.1E-78 T 13-10-2018 IPR013798 Indole-3-glycerol phosphate synthase GO:0004425 KEGG: 00400+4.1.1.48 TOPB45_0586 3113d52dc2a3bd90c8225807cef47dfc 262 Hamap MF_00134_A Indole-3-glycerol phosphate synthase [trpC]. 35 255 30.072 T 13-10-2018 IPR013798 Indole-3-glycerol phosphate synthase GO:0004425 KEGG: 00400+4.1.1.48 TOPB45_1461 79e9ca596e5e99c6081db4489c7d5319 272 SUPERFAMILY SSF56176 189 270 4.36E-19 T 13-10-2018 IPR036318 FAD-binding, type PCMH-like superfamily GO:0050660 TOPB45_1461 79e9ca596e5e99c6081db4489c7d5319 272 Gene3D G3DSA:3.30.465.10 187 263 3.5E-19 T 13-10-2018 IPR016169 FAD-binding, type PCMH, subdomain 2 TOPB45_1461 79e9ca596e5e99c6081db4489c7d5319 272 SUPERFAMILY SSF54631 52 178 2.27E-19 T 13-10-2018 TOPB45_1461 79e9ca596e5e99c6081db4489c7d5319 272 Gene3D G3DSA:3.10.580.10 41 186 2.2E-29 T 13-10-2018 TOPB45_1461 79e9ca596e5e99c6081db4489c7d5319 272 Pfam PF00571 CBS domain 129 178 2.6E-6 T 13-10-2018 IPR000644 CBS domain TOPB45_1461 79e9ca596e5e99c6081db4489c7d5319 272 SMART SM01091 186 264 1.5E-20 T 13-10-2018 IPR005170 Transporter-associated domain TOPB45_1461 79e9ca596e5e99c6081db4489c7d5319 272 Pfam PF03471 Transporter associated domain 190 261 9.9E-19 T 13-10-2018 IPR005170 Transporter-associated domain TOPB45_1626 b3d1143052a74cabff885346bedb68f2 428 Gene3D G3DSA:3.30.930.10 107 428 2.9E-127 T 13-10-2018 TOPB45_1626 b3d1143052a74cabff885346bedb68f2 428 Hamap MF_00176 Serine--tRNA ligase [serS]. 1 423 43.713 T 13-10-2018 IPR002317 Serine-tRNA ligase, type1 GO:0000166|GO:0004828|GO:0005524|GO:0005737|GO:0006434 KEGG: 00970+6.1.1.11|MetaCyc: PWY-6281 TOPB45_1626 b3d1143052a74cabff885346bedb68f2 428 PIRSF PIRSF001529 1 427 5.4E-190 T 13-10-2018 IPR002317 Serine-tRNA ligase, type1 GO:0000166|GO:0004828|GO:0005524|GO:0005737|GO:0006434 KEGG: 00970+6.1.1.11|MetaCyc: PWY-6281 TOPB45_1626 b3d1143052a74cabff885346bedb68f2 428 PRINTS PR00981 Seryl-tRNA synthetase signature 265 277 3.3E-32 T 13-10-2018 IPR002317 Serine-tRNA ligase, type1 GO:0000166|GO:0004828|GO:0005524|GO:0005737|GO:0006434 KEGG: 00970+6.1.1.11|MetaCyc: PWY-6281 TOPB45_1626 b3d1143052a74cabff885346bedb68f2 428 PRINTS PR00981 Seryl-tRNA synthetase signature 352 368 3.3E-32 T 13-10-2018 IPR002317 Serine-tRNA ligase, type1 GO:0000166|GO:0004828|GO:0005524|GO:0005737|GO:0006434 KEGG: 00970+6.1.1.11|MetaCyc: PWY-6281 TOPB45_1626 b3d1143052a74cabff885346bedb68f2 428 PRINTS PR00981 Seryl-tRNA synthetase signature 277 290 3.3E-32 T 13-10-2018 IPR002317 Serine-tRNA ligase, type1 GO:0000166|GO:0004828|GO:0005524|GO:0005737|GO:0006434 KEGG: 00970+6.1.1.11|MetaCyc: PWY-6281 TOPB45_1626 b3d1143052a74cabff885346bedb68f2 428 PRINTS PR00981 Seryl-tRNA synthetase signature 317 330 3.3E-32 T 13-10-2018 IPR002317 Serine-tRNA ligase, type1 GO:0000166|GO:0004828|GO:0005524|GO:0005737|GO:0006434 KEGG: 00970+6.1.1.11|MetaCyc: PWY-6281 TOPB45_1626 b3d1143052a74cabff885346bedb68f2 428 PRINTS PR00981 Seryl-tRNA synthetase signature 334 350 3.3E-32 T 13-10-2018 IPR002317 Serine-tRNA ligase, type1 GO:0000166|GO:0004828|GO:0005524|GO:0005737|GO:0006434 KEGG: 00970+6.1.1.11|MetaCyc: PWY-6281 TOPB45_1626 b3d1143052a74cabff885346bedb68f2 428 TIGRFAM TIGR00414 serS: serine--tRNA ligase 1 418 8.3E-174 T 13-10-2018 IPR002317 Serine-tRNA ligase, type1 GO:0000166|GO:0004828|GO:0005524|GO:0005737|GO:0006434 KEGG: 00970+6.1.1.11|MetaCyc: PWY-6281 TOPB45_1626 b3d1143052a74cabff885346bedb68f2 428 SUPERFAMILY SSF55681 119 420 7.46E-100 T 13-10-2018 TOPB45_1626 b3d1143052a74cabff885346bedb68f2 428 Gene3D G3DSA:1.10.287.40 1 106 4.4E-28 T 13-10-2018 TOPB45_1626 b3d1143052a74cabff885346bedb68f2 428 Pfam PF02403 Seryl-tRNA synthetase N-terminal domain 1 109 1.3E-29 T 13-10-2018 IPR015866 Serine-tRNA synthetase, type1, N-terminal KEGG: 00970+6.1.1.11|MetaCyc: PWY-6281|Reactome: R-HSA-2408557|Reactome: R-HSA-379716 TOPB45_1626 b3d1143052a74cabff885346bedb68f2 428 SUPERFAMILY SSF46589 1 114 1.94E-30 T 13-10-2018 IPR010978 Class I and II aminoacyl-tRNA synthetase, tRNA-binding arm GO:0000166 TOPB45_1626 b3d1143052a74cabff885346bedb68f2 428 Pfam PF00587 tRNA synthetase class II core domain (G, H, P, S and T) 224 401 7.7E-35 T 13-10-2018 IPR002314 Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) GO:0000166|GO:0004812|GO:0005524|GO:0006418 TOPB45_1490 080aad60086bfa0e0175f51f360c8d56 339 TIGRFAM TIGR01409 TAT_signal_seq: Tat (twin-arginine translocation) pathway signal sequence 3 29 6.4E-4 T 13-10-2018 IPR019546 Twin-arginine translocation pathway, signal sequence, bacterial/archaeal TOPB45_1490 080aad60086bfa0e0175f51f360c8d56 339 Pfam PF13247 4Fe-4S dicluster domain 137 234 6.9E-21 T 13-10-2018 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain TOPB45_1490 080aad60086bfa0e0175f51f360c8d56 339 PIRSF PIRSF036298 47 339 1.8E-54 T 13-10-2018 IPR014603 Formate dehydrogenase iron-sulphur subunit GO:0015944|GO:0045333|GO:0051539 TOPB45_1490 080aad60086bfa0e0175f51f360c8d56 339 SUPERFAMILY SSF54862 67 320 3.45E-57 T 13-10-2018 TOPB45_1490 080aad60086bfa0e0175f51f360c8d56 339 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 175 186 - T 13-10-2018 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site TOPB45_1490 080aad60086bfa0e0175f51f360c8d56 339 Gene3D G3DSA:3.30.70.20 142 207 1.8E-71 T 13-10-2018 TOPB45_1490 080aad60086bfa0e0175f51f360c8d56 339 Gene3D G3DSA:3.30.70.20 66 270 1.8E-71 T 13-10-2018 TOPB45_1434 96ee674f992a7acb2ab2487dbaad3a1c 407 Pfam PF00180 Isocitrate/isopropylmalate dehydrogenase 20 399 1.3E-113 T 13-10-2018 IPR024084 Isopropylmalate dehydrogenase-like domain GO:0016616|GO:0055114 Reactome: R-HSA-71403 TOPB45_1434 96ee674f992a7acb2ab2487dbaad3a1c 407 Gene3D G3DSA:3.40.718.10 1 404 6.7E-173 T 13-10-2018 TOPB45_1434 96ee674f992a7acb2ab2487dbaad3a1c 407 TIGRFAM TIGR00183 prok_nadp_idh: isocitrate dehydrogenase, NADP-dependent 9 403 4.1E-198 T 13-10-2018 IPR004439 Isocitrate dehydrogenase NADP-dependent, dimeric, prokaryotic GO:0004450|GO:0006099|GO:0055114 KEGG: 00020+1.1.1.42|KEGG: 00480+1.1.1.42|KEGG: 00720+1.1.1.42|MetaCyc: PWY-5913|MetaCyc: PWY-6549|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7124|MetaCyc: PWY-7254|MetaCyc: PWY-7268 TOPB45_1434 96ee674f992a7acb2ab2487dbaad3a1c 407 SMART SM01329 19 399 2.3E-187 T 13-10-2018 IPR024084 Isopropylmalate dehydrogenase-like domain GO:0016616|GO:0055114 Reactome: R-HSA-71403 TOPB45_1434 96ee674f992a7acb2ab2487dbaad3a1c 407 ProSitePatterns PS00470 Isocitrate and isopropylmalate dehydrogenases signature. 290 309 - T 13-10-2018 IPR019818 Isocitrate/isopropylmalate dehydrogenase, conserved site GO:0000287|GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-71403 TOPB45_1434 96ee674f992a7acb2ab2487dbaad3a1c 407 SUPERFAMILY SSF53659 9 403 1.42E-141 T 13-10-2018 TOPB45_0046 bf12320027ae96c30c0a371480d980f2 386 PIRSF PIRSF006205 1 386 6.8E-137 T 13-10-2018 IPR003821 1-deoxy-D-xylulose 5-phosphate reductoisomerase GO:0008299|GO:0030604|GO:0046872|GO:0055114 KEGG: 00900+1.1.1.267|MetaCyc: PWY-7560 TOPB45_0046 bf12320027ae96c30c0a371480d980f2 386 Pfam PF08436 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal 143 226 5.2E-36 T 13-10-2018 IPR013644 1-deoxy-D-xylulose 5-phosphate reductoisomerase, C-terminal GO:0005515 KEGG: 00900+1.1.1.267|MetaCyc: PWY-7560 TOPB45_0046 bf12320027ae96c30c0a371480d980f2 386 Gene3D G3DSA:1.10.1740.10 298 385 7.1E-21 T 13-10-2018 TOPB45_0046 bf12320027ae96c30c0a371480d980f2 386 Gene3D G3DSA:3.40.50.720 1 147 5.2E-44 T 13-10-2018 TOPB45_0046 bf12320027ae96c30c0a371480d980f2 386 SUPERFAMILY SSF69055 290 382 5.23E-21 T 13-10-2018 IPR036169 DXP reductoisomerase, C-terminal domain superfamily KEGG: 00900+1.1.1.267|MetaCyc: PWY-7560 TOPB45_0046 bf12320027ae96c30c0a371480d980f2 386 SUPERFAMILY SSF51735 2 147 2.07E-34 T 13-10-2018 IPR036291 NAD(P)-binding domain superfamily TOPB45_0046 bf12320027ae96c30c0a371480d980f2 386 Pfam PF13288 DXP reductoisomerase C-terminal domain 259 373 7.1E-31 T 13-10-2018 IPR026877 DXP reductoisomerase C-terminal domain KEGG: 00900+1.1.1.267|MetaCyc: PWY-7560 TOPB45_0046 bf12320027ae96c30c0a371480d980f2 386 Pfam PF02670 1-deoxy-D-xylulose 5-phosphate reductoisomerase 4 129 6.2E-35 T 13-10-2018 IPR013512 1-deoxy-D-xylulose 5-phosphate reductoisomerase, N-terminal GO:0055114|GO:0070402 KEGG: 00900+1.1.1.267|MetaCyc: PWY-7560 TOPB45_0046 bf12320027ae96c30c0a371480d980f2 386 Hamap MF_00183 1-deoxy-D-xylulose 5-phosphate reductoisomerase [dxr]. 4 380 41.266 T 13-10-2018 IPR003821 1-deoxy-D-xylulose 5-phosphate reductoisomerase GO:0008299|GO:0030604|GO:0046872|GO:0055114 KEGG: 00900+1.1.1.267|MetaCyc: PWY-7560 TOPB45_0046 bf12320027ae96c30c0a371480d980f2 386 TIGRFAM TIGR00243 Dxr: 1-deoxy-D-xylulose 5-phosphate reductoisomerase 1 377 6.5E-118 T 13-10-2018 IPR003821 1-deoxy-D-xylulose 5-phosphate reductoisomerase GO:0008299|GO:0030604|GO:0046872|GO:0055114 KEGG: 00900+1.1.1.267|MetaCyc: PWY-7560 TOPB45_0046 bf12320027ae96c30c0a371480d980f2 386 SUPERFAMILY SSF55347 123 259 4.9E-51 T 13-10-2018 TOPB45_0942 a624a6a51159ac8a1ad44545d50be39d 467 Pfam PF08245 Mur ligase middle domain 114 293 2.5E-33 T 13-10-2018 IPR013221 Mur ligase, central GO:0005524|GO:0009058 TOPB45_0942 a624a6a51159ac8a1ad44545d50be39d 467 Gene3D G3DSA:3.90.190.20 321 455 3.3E-42 T 13-10-2018 IPR036615 Mur ligase, C-terminal domain superfamily GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 TOPB45_0942 a624a6a51159ac8a1ad44545d50be39d 467 TIGRFAM TIGR01087 murD: UDP-N-acetylmuramoylalanine--D-glutamate ligase 7 450 5.3E-119 T 13-10-2018 IPR005762 UDP-N-acetylmuramoylalanine-D-glutamate ligase GO:0005524|GO:0005737|GO:0008360|GO:0008764|GO:0051301 KEGG: 00471+6.3.2.9|KEGG: 00550+6.3.2.9|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TOPB45_0942 a624a6a51159ac8a1ad44545d50be39d 467 SUPERFAMILY SSF53244 315 452 6.18E-43 T 13-10-2018 IPR036615 Mur ligase, C-terminal domain superfamily GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 TOPB45_0942 a624a6a51159ac8a1ad44545d50be39d 467 Hamap MF_00639 UDP-N-acetylmuramoylalanine--D-glutamate ligase [murD]. 6 453 31.954 T 13-10-2018 IPR005762 UDP-N-acetylmuramoylalanine-D-glutamate ligase GO:0005524|GO:0005737|GO:0008360|GO:0008764|GO:0051301 KEGG: 00471+6.3.2.9|KEGG: 00550+6.3.2.9|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TOPB45_0942 a624a6a51159ac8a1ad44545d50be39d 467 SUPERFAMILY SSF51984 2 82 1.7E-12 T 13-10-2018 TOPB45_0942 a624a6a51159ac8a1ad44545d50be39d 467 Gene3D G3DSA:3.40.50.720 1 95 4.0E-18 T 13-10-2018 TOPB45_0942 a624a6a51159ac8a1ad44545d50be39d 467 Pfam PF02875 Mur ligase family, glutamate ligase domain 317 386 1.9E-10 T 13-10-2018 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 TOPB45_0942 a624a6a51159ac8a1ad44545d50be39d 467 SUPERFAMILY SSF53623 105 313 5.49E-45 T 13-10-2018 IPR036565 Mur-like, catalytic domain superfamily GO:0005524|GO:0009058 Reactome: R-HSA-196757 TOPB45_0942 a624a6a51159ac8a1ad44545d50be39d 467 Gene3D G3DSA:3.40.1190.10 97 313 6.6E-49 T 13-10-2018 IPR036565 Mur-like, catalytic domain superfamily GO:0005524|GO:0009058 Reactome: R-HSA-196757 TOPB45_1038 32cab4736fee8a25fa1f594b35a1844b 116 Pfam PF07238 PilZ domain 5 102 3.6E-13 T 13-10-2018 IPR009875 PilZ domain GO:0035438 TOPB45_1038 32cab4736fee8a25fa1f594b35a1844b 116 SUPERFAMILY SSF141371 4 103 7.06E-13 T 13-10-2018 TOPB45_1038 32cab4736fee8a25fa1f594b35a1844b 116 Gene3D G3DSA:2.40.10.220 1 114 9.2E-17 T 13-10-2018 TOPB45_0137 d9acdd88f254136a9dc36e7bc3e06b22 263 Gene3D G3DSA:3.40.50.1860 2 251 3.6E-89 T 13-10-2018 TOPB45_0137 d9acdd88f254136a9dc36e7bc3e06b22 263 SUPERFAMILY SSF53681 2 104 2.06E-32 T 13-10-2018 IPR001920 Asp/Glu racemase GO:0016855 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TOPB45_0137 d9acdd88f254136a9dc36e7bc3e06b22 263 SUPERFAMILY SSF53681 106 258 1.24E-36 T 13-10-2018 IPR001920 Asp/Glu racemase GO:0016855 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TOPB45_0137 d9acdd88f254136a9dc36e7bc3e06b22 263 Gene3D G3DSA:3.40.50.1860 92 204 3.6E-89 T 13-10-2018 TOPB45_0137 d9acdd88f254136a9dc36e7bc3e06b22 263 Hamap MF_00258 Glutamate racemase [murI]. 1 254 33.24 T 13-10-2018 IPR004391 Glutamate racemase GO:0008881|GO:0009252 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TOPB45_0137 d9acdd88f254136a9dc36e7bc3e06b22 263 Pfam PF01177 Asp/Glu/Hydantoin racemase 2 210 6.4E-35 T 13-10-2018 IPR015942 Asp/Glu/hydantoin racemase GO:0006807|GO:0036361 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TOPB45_0137 d9acdd88f254136a9dc36e7bc3e06b22 263 ProSitePatterns PS00924 Aspartate and glutamate racemases signature 2. 177 187 - T 13-10-2018 IPR033134 Asp/Glu racemase, active site 2 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TOPB45_0137 d9acdd88f254136a9dc36e7bc3e06b22 263 TIGRFAM TIGR00067 glut_race: glutamate racemase 2 251 5.9E-66 T 13-10-2018 IPR004391 Glutamate racemase GO:0008881|GO:0009252 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387 TOPB45_0872 7c9dc213fe1464413ed501500073c855 357 Pfam PF13180 PDZ domain 109 170 4.2E-9 T 13-10-2018 IPR001478 PDZ domain GO:0005515 TOPB45_0872 7c9dc213fe1464413ed501500073c855 357 SUPERFAMILY SSF50156 82 171 1.24E-14 T 13-10-2018 IPR036034 PDZ superfamily GO:0005515 TOPB45_0872 7c9dc213fe1464413ed501500073c855 357 Gene3D G3DSA:2.30.42.10 77 173 9.5E-14 T 13-10-2018 TOPB45_0872 7c9dc213fe1464413ed501500073c855 357 Pfam PF01435 Peptidase family M48 179 328 4.1E-23 T 13-10-2018 IPR001915 Peptidase M48 GO:0004222|GO:0006508 TOPB45_0872 7c9dc213fe1464413ed501500073c855 357 SMART SM00228 80 164 3.8E-7 T 13-10-2018 IPR001478 PDZ domain GO:0005515 TOPB45_0357 fb6237e6507efd67a74b62ae8aee3664 136 Pfam PF01850 PIN domain 2 121 2.6E-16 T 13-10-2018 IPR002716 PIN domain TOPB45_0357 fb6237e6507efd67a74b62ae8aee3664 136 Gene3D G3DSA:3.40.50.1010 2 135 5.5E-15 T 13-10-2018 TOPB45_0357 fb6237e6507efd67a74b62ae8aee3664 136 Hamap MF_00265 tRNA(fMet)-specific endonuclease VapC [vapC]. 2 127 9.67 T 13-10-2018 IPR022907 VapC family GO:0004540 TOPB45_0357 fb6237e6507efd67a74b62ae8aee3664 136 SUPERFAMILY SSF88723 1 130 2.27E-21 T 13-10-2018 IPR029060 PIN-like domain superfamily TOPB45_0499 265d9a50cbd52d81bc26c1fe400d4107 247 Pfam PF04216 Protein involved in formate dehydrogenase formation 113 240 1.4E-18 T 13-10-2018 IPR006452 Formate dehydrogenase accessory protein GO:0005737 TOPB45_0499 265d9a50cbd52d81bc26c1fe400d4107 247 SUPERFAMILY SSF144020 110 242 3.4E-27 T 13-10-2018 IPR024064 FdhE-like superfamily TOPB45_0499 265d9a50cbd52d81bc26c1fe400d4107 247 Gene3D G3DSA:3.90.1670.10 33 245 2.6E-28 T 13-10-2018 IPR024064 FdhE-like superfamily TOPB45_0275 5226bbf48313da08b6fdf978f66fff25 274 Pfam PF00753 Metallo-beta-lactamase superfamily 24 118 7.9E-14 T 13-10-2018 IPR001279 Metallo-beta-lactamase TOPB45_0275 5226bbf48313da08b6fdf978f66fff25 274 SMART SM00849 23 245 9.2E-4 T 13-10-2018 IPR001279 Metallo-beta-lactamase TOPB45_0275 5226bbf48313da08b6fdf978f66fff25 274 Gene3D G3DSA:3.60.15.10 1 274 6.8E-91 T 13-10-2018 IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like TOPB45_0275 5226bbf48313da08b6fdf978f66fff25 274 SUPERFAMILY SSF56281 20 274 6.68E-33 T 13-10-2018 IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like TOPB45_1044 a5de9890a98757522efb51de319b73c2 310 SUPERFAMILY SSF110849 23 99 1.29E-10 T 13-10-2018 IPR036086 ParB/Sulfiredoxin superfamily TOPB45_1044 a5de9890a98757522efb51de319b73c2 310 Pfam PF02195 ParB-like nuclease domain 25 96 3.1E-8 T 13-10-2018 IPR003115 ParB/Sulfiredoxin TOPB45_1044 a5de9890a98757522efb51de319b73c2 310 SMART SM00470 6 97 4.5E-6 T 13-10-2018 IPR003115 ParB/Sulfiredoxin TOPB45_1044 a5de9890a98757522efb51de319b73c2 310 Gene3D G3DSA:3.90.1530.30 18 81 6.7E-7 T 13-10-2018 TOPB45_0015 03a4f7ca2015519e5ffd321541c9fa8d 413 Gene3D G3DSA:3.40.47.10 255 399 4.5E-59 T 13-10-2018 IPR016039 Thiolase-like GO:0003824 TOPB45_0015 03a4f7ca2015519e5ffd321541c9fa8d 413 TIGRFAM TIGR03150 fabF: beta-ketoacyl-acyl-carrier-protein synthase II 3 408 2.4E-199 T 13-10-2018 IPR017568 3-oxoacyl-[acyl-carrier-protein] synthase 2 GO:0006633|GO:0016747 TOPB45_0015 03a4f7ca2015519e5ffd321541c9fa8d 413 SUPERFAMILY SSF53901 3 250 2.79E-78 T 13-10-2018 IPR016039 Thiolase-like GO:0003824 TOPB45_0015 03a4f7ca2015519e5ffd321541c9fa8d 413 SMART SM00825 Beta-ketoacyl synthase 5 412 1.3E-18 T 13-10-2018 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain TOPB45_0015 03a4f7ca2015519e5ffd321541c9fa8d 413 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 153 169 - T 13-10-2018 IPR018201 Beta-ketoacyl synthase, active site TOPB45_0015 03a4f7ca2015519e5ffd321541c9fa8d 413 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 253 367 4.8E-42 T 13-10-2018 IPR014031 Beta-ketoacyl synthase, C-terminal TOPB45_0015 03a4f7ca2015519e5ffd321541c9fa8d 413 SUPERFAMILY SSF53901 213 411 1.7E-77 T 13-10-2018 IPR016039 Thiolase-like GO:0003824 TOPB45_0015 03a4f7ca2015519e5ffd321541c9fa8d 413 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 3 245 4.5E-62 T 13-10-2018 IPR014030 Beta-ketoacyl synthase, N-terminal TOPB45_0015 03a4f7ca2015519e5ffd321541c9fa8d 413 PIRSF PIRSF000447 1 412 2.0E-191 T 13-10-2018 IPR017568 3-oxoacyl-[acyl-carrier-protein] synthase 2 GO:0006633|GO:0016747 TOPB45_0015 03a4f7ca2015519e5ffd321541c9fa8d 413 Gene3D G3DSA:3.40.47.10 1 253 1.5E-96 T 13-10-2018 IPR016039 Thiolase-like GO:0003824 TOPB45_0319 7e8ac55160ecb4a6a58b42e9faa8d5d3 417 Pfam PF00990 Diguanylate cyclase, GGDEF domain 254 413 6.4E-40 T 13-10-2018 IPR000160 GGDEF domain TOPB45_0319 7e8ac55160ecb4a6a58b42e9faa8d5d3 417 SUPERFAMILY SSF55073 259 417 1.33E-38 T 13-10-2018 IPR029787 Nucleotide cyclase TOPB45_0319 7e8ac55160ecb4a6a58b42e9faa8d5d3 417 SUPERFAMILY SSF52172 2 118 1.71E-16 T 13-10-2018 IPR011006 CheY-like superfamily TOPB45_0319 7e8ac55160ecb4a6a58b42e9faa8d5d3 417 Gene3D G3DSA:3.30.70.270 247 416 4.9E-48 T 13-10-2018 TOPB45_0319 7e8ac55160ecb4a6a58b42e9faa8d5d3 417 SMART SM00267 243 417 1.1E-41 T 13-10-2018 IPR000160 GGDEF domain TOPB45_0319 7e8ac55160ecb4a6a58b42e9faa8d5d3 417 SUPERFAMILY SSF52172 122 257 7.97E-29 T 13-10-2018 IPR011006 CheY-like superfamily TOPB45_0319 7e8ac55160ecb4a6a58b42e9faa8d5d3 417 Gene3D G3DSA:3.40.50.2300 123 246 1.0E-27 T 13-10-2018 TOPB45_0319 7e8ac55160ecb4a6a58b42e9faa8d5d3 417 TIGRFAM TIGR00254 GGDEF: diguanylate cyclase (GGDEF) domain 250 415 1.3E-45 T 13-10-2018 IPR000160 GGDEF domain TOPB45_0319 7e8ac55160ecb4a6a58b42e9faa8d5d3 417 Pfam PF00072 Response regulator receiver domain 4 102 2.2E-10 T 13-10-2018 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TOPB45_0319 7e8ac55160ecb4a6a58b42e9faa8d5d3 417 Pfam PF00072 Response regulator receiver domain 125 237 2.6E-19 T 13-10-2018 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TOPB45_0319 7e8ac55160ecb4a6a58b42e9faa8d5d3 417 Gene3D G3DSA:3.40.50.2300 1 121 7.2E-17 T 13-10-2018 TOPB45_0319 7e8ac55160ecb4a6a58b42e9faa8d5d3 417 SMART SM00448 123 237 6.9E-22 T 13-10-2018 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TOPB45_0319 7e8ac55160ecb4a6a58b42e9faa8d5d3 417 SMART SM00448 2 111 4.6E-7 T 13-10-2018 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TOPB45_1184 af7c49f0a7d0c6925c7c9e777d9b47e6 393 Pfam PF04966 Carbohydrate-selective porin, OprB family 121 348 5.7E-10 T 13-10-2018 IPR007049 Carbohydrate-selective porin OprB GO:0008643|GO:0015288|GO:0016021 TOPB45_1184 af7c49f0a7d0c6925c7c9e777d9b47e6 393 Gene3D G3DSA:2.40.160.180 72 393 1.7E-12 T 13-10-2018 IPR038673 Carbohydrate-selective porin OprB superfamily TOPB45_0447 41263cfd796d3cba7231adc63f7b4ef7 267 Pfam PF08443 RimK-like ATP-grasp domain 103 233 3.8E-10 T 13-10-2018 IPR013651 ATP-grasp fold, RimK-type Reactome: R-HSA-70614 TOPB45_0447 41263cfd796d3cba7231adc63f7b4ef7 267 Gene3D G3DSA:3.30.470.20 147 254 2.9E-14 T 13-10-2018 TOPB45_0447 41263cfd796d3cba7231adc63f7b4ef7 267 SUPERFAMILY SSF56059 75 232 6.41E-18 T 13-10-2018 TOPB45_0787 a465b6424e5f29a07a59d8c3bf047758 807 SUPERFAMILY SSF54211 595 770 1.37E-58 T 13-10-2018 IPR020568 Ribosomal protein S5 domain 2-type fold TOPB45_0787 a465b6424e5f29a07a59d8c3bf047758 807 Gene3D G3DSA:2.30.130.40 2 115 5.0E-33 T 13-10-2018 TOPB45_0787 a465b6424e5f29a07a59d8c3bf047758 807 Gene3D G3DSA:3.40.50.300 311 489 2.5E-66 T 13-10-2018 TOPB45_0787 a465b6424e5f29a07a59d8c3bf047758 807 SUPERFAMILY SSF52540 309 588 2.93E-52 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0787 a465b6424e5f29a07a59d8c3bf047758 807 Gene3D G3DSA:1.10.8.60 490 584 3.8E-33 T 13-10-2018 TOPB45_0787 a465b6424e5f29a07a59d8c3bf047758 807 Hamap MF_01973 Lon protease [lon]. 9 772 71.819 T 13-10-2018 IPR027543 Lon protease, bacterial GO:0004176|GO:0004252|GO:0005524|GO:0006508|GO:0043565 TOPB45_0787 a465b6424e5f29a07a59d8c3bf047758 807 ProSitePatterns PS01046 ATP-dependent serine proteases, lon family, serine active site. 676 684 - T 13-10-2018 IPR008268 Peptidase S16, active site GO:0004176|GO:0004252|GO:0006508 TOPB45_0787 a465b6424e5f29a07a59d8c3bf047758 807 SUPERFAMILY SSF88697 8 199 5.22E-47 T 13-10-2018 IPR015947 PUA-like superfamily TOPB45_0787 a465b6424e5f29a07a59d8c3bf047758 807 Pfam PF05362 Lon protease (S16) C-terminal proteolytic domain 570 771 8.2E-93 T 13-10-2018 IPR008269 Peptidase S16, Lon proteolytic domain GO:0004176|GO:0004252|GO:0006508 TOPB45_0787 a465b6424e5f29a07a59d8c3bf047758 807 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 350 487 2.7E-21 T 13-10-2018 IPR003959 ATPase, AAA-type, core GO:0005524 TOPB45_0787 a465b6424e5f29a07a59d8c3bf047758 807 PRINTS PR00830 Endopeptidase La (Lon) serine protease (S16) signature 673 692 4.5E-54 T 13-10-2018 TOPB45_0787 a465b6424e5f29a07a59d8c3bf047758 807 PRINTS PR00830 Endopeptidase La (Lon) serine protease (S16) signature 354 373 4.5E-54 T 13-10-2018 TOPB45_0787 a465b6424e5f29a07a59d8c3bf047758 807 PRINTS PR00830 Endopeptidase La (Lon) serine protease (S16) signature 703 722 4.5E-54 T 13-10-2018 TOPB45_0787 a465b6424e5f29a07a59d8c3bf047758 807 PRINTS PR00830 Endopeptidase La (Lon) serine protease (S16) signature 726 744 4.5E-54 T 13-10-2018 TOPB45_0787 a465b6424e5f29a07a59d8c3bf047758 807 PRINTS PR00830 Endopeptidase La (Lon) serine protease (S16) signature 595 611 4.5E-54 T 13-10-2018 TOPB45_0787 a465b6424e5f29a07a59d8c3bf047758 807 Pfam PF02190 ATP-dependent protease La (LON) substrate-binding domain 8 198 5.6E-41 T 13-10-2018 IPR003111 Lon, substrate-binding domain TOPB45_0787 a465b6424e5f29a07a59d8c3bf047758 807 PIRSF PIRSF001174 1 775 0.0 T 13-10-2018 IPR004815 Lon protease, bacterial/eukaryotic-type GO:0004176|GO:0005524|GO:0006508 TOPB45_0787 a465b6424e5f29a07a59d8c3bf047758 807 SMART SM00464 8 200 9.4E-62 T 13-10-2018 IPR003111 Lon, substrate-binding domain TOPB45_0787 a465b6424e5f29a07a59d8c3bf047758 807 Gene3D G3DSA:3.30.230.10 585 772 2.4E-79 T 13-10-2018 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup TOPB45_0787 a465b6424e5f29a07a59d8c3bf047758 807 Gene3D G3DSA:1.20.58.1480 119 243 1.1E-36 T 13-10-2018 TOPB45_0787 a465b6424e5f29a07a59d8c3bf047758 807 TIGRFAM TIGR00763 lon: endopeptidase La 10 771 1.6E-298 T 13-10-2018 IPR004815 Lon protease, bacterial/eukaryotic-type GO:0004176|GO:0005524|GO:0006508 TOPB45_0787 a465b6424e5f29a07a59d8c3bf047758 807 SMART SM00382 346 491 1.1E-12 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_0448 d52ac02c53d815db5fd14086ed02719f 583 SUPERFAMILY SSF53756 127 341 3.98E-7 T 13-10-2018 TOPB45_0448 d52ac02c53d815db5fd14086ed02719f 583 Gene3D G3DSA:3.40.50.2000 1 322 1.6E-35 T 13-10-2018 TOPB45_0370 1d4e05b256ee387d1ce8f4414fd92117 385 Gene3D G3DSA:3.90.1150.10 18 379 2.6E-133 T 13-10-2018 IPR015422 Pyridoxal phosphate-dependent transferase domain 1 GO:0003824 TOPB45_0370 1d4e05b256ee387d1ce8f4414fd92117 385 SUPERFAMILY SSF53383 1 380 2.2E-109 T 13-10-2018 IPR015424 Pyridoxal phosphate-dependent transferase TOPB45_0370 1d4e05b256ee387d1ce8f4414fd92117 385 TIGRFAM TIGR03540 DapC_direct: LL-diaminopimelate aminotransferase 3 380 7.6E-190 T 13-10-2018 IPR019881 Diaminopimelate aminotransferase, DapL, Desulfovibrio-type GO:0009089|GO:0010285 KEGG: 00300+2.6.1.83|MetaCyc: PWY-5097 TOPB45_0370 1d4e05b256ee387d1ce8f4414fd92117 385 Pfam PF00155 Aminotransferase class I and II 31 380 2.0E-64 T 13-10-2018 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 TOPB45_0370 1d4e05b256ee387d1ce8f4414fd92117 385 Gene3D G3DSA:3.40.640.10 42 282 2.6E-133 T 13-10-2018 IPR015421 Pyridoxal phosphate-dependent transferase, major domain GO:0003824 TOPB45_1363 e45f7749b3935420f130d03823d0a31d 453 Pfam PF01171 PP-loop family 22 201 9.0E-50 T 13-10-2018 IPR011063 tRNA(Ile)-lysidine/2-thiocytidine synthase, N-terminal Reactome: R-HSA-6782315 TOPB45_1363 e45f7749b3935420f130d03823d0a31d 453 SUPERFAMILY SSF56037 330 449 2.2E-16 T 13-10-2018 TOPB45_1363 e45f7749b3935420f130d03823d0a31d 453 Hamap MF_01161 tRNA(Ile)-lysidine synthase [tilS]. 6 314 24.204 T 13-10-2018 IPR012094 tRNA(Ile)-lysidine synthase GO:0000166|GO:0005524|GO:0005737|GO:0008033|GO:0016879 TOPB45_1363 e45f7749b3935420f130d03823d0a31d 453 TIGRFAM TIGR02433 lysidine_TilS_C: tRNA(Ile)-lysidine synthetase, C-terminal domain 380 422 5.0E-9 T 13-10-2018 IPR012796 Lysidine-tRNA(Ile) synthetase, C-terminal GO:0000166|GO:0005524|GO:0005737|GO:0008033|GO:0016879 TOPB45_1363 e45f7749b3935420f130d03823d0a31d 453 SUPERFAMILY SSF82829 215 319 7.06E-12 T 13-10-2018 TOPB45_1363 e45f7749b3935420f130d03823d0a31d 453 TIGRFAM TIGR02432 lysidine_TilS_N: tRNA(Ile)-lysidine synthetase 21 205 7.7E-54 T 13-10-2018 IPR012795 tRNA(Ile)-lysidine synthase, N-terminal GO:0000166|GO:0005524|GO:0005737|GO:0008033|GO:0016879 TOPB45_1363 e45f7749b3935420f130d03823d0a31d 453 SMART SM00977 379 450 7.5E-12 T 13-10-2018 IPR012796 Lysidine-tRNA(Ile) synthetase, C-terminal GO:0000166|GO:0005524|GO:0005737|GO:0008033|GO:0016879 TOPB45_1363 e45f7749b3935420f130d03823d0a31d 453 SUPERFAMILY SSF52402 2 210 5.29E-55 T 13-10-2018 TOPB45_1363 e45f7749b3935420f130d03823d0a31d 453 Pfam PF11734 TilS substrate C-terminal domain 381 446 1.0E-7 T 13-10-2018 IPR012796 Lysidine-tRNA(Ile) synthetase, C-terminal GO:0000166|GO:0005524|GO:0005737|GO:0008033|GO:0016879 TOPB45_1363 e45f7749b3935420f130d03823d0a31d 453 Gene3D G3DSA:3.40.50.620 1 211 5.8E-65 T 13-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TOPB45_1120 5df25a120c1a34382862f812785933f4 133 Gene3D G3DSA:3.10.490.10 1 127 2.6E-27 T 13-10-2018 TOPB45_1120 5df25a120c1a34382862f812785933f4 133 SUPERFAMILY SSF110857 1 99 4.19E-17 T 13-10-2018 IPR036568 Gamma-glutamyl cyclotransferase-like superfamily TOPB45_1120 5df25a120c1a34382862f812785933f4 133 Pfam PF06094 Gamma-glutamyl cyclotransferase, AIG2-like 4 102 2.4E-10 T 13-10-2018 IPR009288 Gamma-glutamylcyclotransferase, AIG2-like TOPB45_0244 53b0c0d04faed04e27354f80f6e7ebfa 343 Gene3D G3DSA:3.90.180.10 17 335 4.1E-79 T 13-10-2018 TOPB45_0244 53b0c0d04faed04e27354f80f6e7ebfa 343 SUPERFAMILY SSF51735 144 305 1.39E-20 T 13-10-2018 IPR036291 NAD(P)-binding domain superfamily TOPB45_0244 53b0c0d04faed04e27354f80f6e7ebfa 343 SUPERFAMILY SSF50129 14 163 2.13E-49 T 13-10-2018 IPR011032 GroES-like superfamily TOPB45_0244 53b0c0d04faed04e27354f80f6e7ebfa 343 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 32 138 2.9E-30 T 13-10-2018 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 TOPB45_0244 53b0c0d04faed04e27354f80f6e7ebfa 343 Gene3D G3DSA:3.40.50.720 153 290 4.1E-79 T 13-10-2018 TOPB45_0738 0967c7305dd55cf947e693678c216879 175 Gene3D G3DSA:3.40.109.10 5 174 7.9E-53 T 13-10-2018 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 TOPB45_0738 0967c7305dd55cf947e693678c216879 175 Pfam PF00881 Nitroreductase family 15 70 1.5E-16 T 13-10-2018 IPR029479 Nitroreductase Reactome: R-HSA-209968 TOPB45_0738 0967c7305dd55cf947e693678c216879 175 Pfam PF00881 Nitroreductase family 73 154 1.5E-16 T 13-10-2018 IPR029479 Nitroreductase Reactome: R-HSA-209968 TOPB45_0738 0967c7305dd55cf947e693678c216879 175 SUPERFAMILY SSF55469 10 172 9.29E-51 T 13-10-2018 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 TOPB45_1633 2d7f91fefe40d8e0b8f2113afe5386e3 161 Gene3D G3DSA:3.10.50.40 4 151 4.5E-35 T 13-10-2018 TOPB45_1633 2d7f91fefe40d8e0b8f2113afe5386e3 161 Pfam PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 6 138 2.4E-8 T 13-10-2018 IPR001179 FKBP-type peptidyl-prolyl cis-trans isomerase domain TOPB45_1633 2d7f91fefe40d8e0b8f2113afe5386e3 161 SUPERFAMILY SSF54534 4 142 1.75E-21 T 13-10-2018 TOPB45_1633 2d7f91fefe40d8e0b8f2113afe5386e3 161 Gene3D G3DSA:2.40.10.330 72 123 4.5E-35 T 13-10-2018 TOPB45_0430 dae3dc6e63874af8ef370146e115d994 342 Pfam PF02272 DHHA1 domain 212 306 3.7E-8 T 13-10-2018 IPR003156 DHHA1 domain GO:0003676 KEGG: 00970+6.1.1.7|Reactome: R-HSA-379716 TOPB45_0430 dae3dc6e63874af8ef370146e115d994 342 SUPERFAMILY SSF64182 37 309 4.06E-42 T 13-10-2018 IPR038763 DHH phosphoesterase superfamily TOPB45_0430 dae3dc6e63874af8ef370146e115d994 342 Pfam PF01368 DHH family 37 170 7.7E-7 T 13-10-2018 IPR001667 DDH domain KEGG: 00190+3.6.1.1|MetaCyc: PWY-7805|MetaCyc: PWY-7807 TOPB45_0430 dae3dc6e63874af8ef370146e115d994 342 Gene3D G3DSA:3.90.1640.10 32 205 3.5E-22 T 13-10-2018 TOPB45_0490 c02343c1de6f3d3dd63895ac29f7dbca 437 PRINTS PR01874 DNA repair protein radA signature 5 29 1.9E-89 T 13-10-2018 TOPB45_0490 c02343c1de6f3d3dd63895ac29f7dbca 437 PRINTS PR01874 DNA repair protein radA signature 303 326 1.9E-89 T 13-10-2018 TOPB45_0490 c02343c1de6f3d3dd63895ac29f7dbca 437 PRINTS PR01874 DNA repair protein radA signature 112 129 1.9E-89 T 13-10-2018 TOPB45_0490 c02343c1de6f3d3dd63895ac29f7dbca 437 PRINTS PR01874 DNA repair protein radA signature 161 185 1.9E-89 T 13-10-2018 TOPB45_0490 c02343c1de6f3d3dd63895ac29f7dbca 437 PRINTS PR01874 DNA repair protein radA signature 200 228 1.9E-89 T 13-10-2018 TOPB45_0490 c02343c1de6f3d3dd63895ac29f7dbca 437 PRINTS PR01874 DNA repair protein radA signature 235 261 1.9E-89 T 13-10-2018 TOPB45_0490 c02343c1de6f3d3dd63895ac29f7dbca 437 PRINTS PR01874 DNA repair protein radA signature 70 98 1.9E-89 T 13-10-2018 TOPB45_0490 c02343c1de6f3d3dd63895ac29f7dbca 437 SMART SM00382 78 231 5.0E-11 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_0490 c02343c1de6f3d3dd63895ac29f7dbca 437 Gene3D G3DSA:3.30.230.10 314 437 5.8E-21 T 13-10-2018 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup TOPB45_0490 c02343c1de6f3d3dd63895ac29f7dbca 437 Pfam PF13481 AAA domain 61 208 1.4E-14 T 13-10-2018 TOPB45_0490 c02343c1de6f3d3dd63895ac29f7dbca 437 SUPERFAMILY SSF54211 242 436 3.75E-36 T 13-10-2018 IPR020568 Ribosomal protein S5 domain 2-type fold TOPB45_0490 c02343c1de6f3d3dd63895ac29f7dbca 437 Hamap MF_01498 DNA repair protein RadA [radA]. 16 436 40.555 T 13-10-2018 IPR004504 DNA repair protein RadA GO:0003684|GO:0005524|GO:0006281 TOPB45_0490 c02343c1de6f3d3dd63895ac29f7dbca 437 Gene3D G3DSA:3.40.50.300 56 271 5.1E-43 T 13-10-2018 TOPB45_0490 c02343c1de6f3d3dd63895ac29f7dbca 437 Pfam PF13541 Subunit ChlI of Mg-chelatase 325 410 1.4E-11 T 13-10-2018 TOPB45_0490 c02343c1de6f3d3dd63895ac29f7dbca 437 SUPERFAMILY SSF52540 37 260 5.31E-51 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0490 c02343c1de6f3d3dd63895ac29f7dbca 437 TIGRFAM TIGR00416 sms: DNA repair protein RadA 2 431 1.3E-163 T 13-10-2018 IPR004504 DNA repair protein RadA GO:0003684|GO:0005524|GO:0006281 TOPB45_0932 4432b0a99e8b466c1db4c975edadf36a 262 SUPERFAMILY SSF161098 5 254 2.09E-36 T 13-10-2018 IPR035906 MetI-like superfamily TOPB45_0932 4432b0a99e8b466c1db4c975edadf36a 262 Gene3D G3DSA:1.10.3720.10 2 261 1.6E-42 T 13-10-2018 IPR035906 MetI-like superfamily TOPB45_0932 4432b0a99e8b466c1db4c975edadf36a 262 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 78 256 2.7E-17 T 13-10-2018 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0016020|GO:0055085 TOPB45_1487 861f951463ad234234f2a3c49519feb9 181 SUPERFAMILY SSF53271 10 179 2.36E-51 T 13-10-2018 IPR029057 Phosphoribosyltransferase-like TOPB45_1487 861f951463ad234234f2a3c49519feb9 181 Pfam PF00156 Phosphoribosyl transferase domain 14 164 1.5E-25 T 13-10-2018 IPR000836 Phosphoribosyltransferase domain GO:0009116 TOPB45_1487 861f951463ad234234f2a3c49519feb9 181 TIGRFAM TIGR01203 HGPRTase: hypoxanthine phosphoribosyltransferase 13 176 5.0E-61 T 13-10-2018 IPR005904 Hypoxanthine phosphoribosyl transferase GO:0004422|GO:0005737|GO:0006166 KEGG: 00230+2.4.2.8|KEGG: 00983+2.4.2.8|MetaCyc: PWY-6599|MetaCyc: PWY-6609|MetaCyc: PWY-6610|MetaCyc: PWY-6620 TOPB45_1487 861f951463ad234234f2a3c49519feb9 181 Gene3D G3DSA:3.40.50.2020 2 181 6.9E-65 T 13-10-2018 TOPB45_0467 f800104845a79e1e09c73268d8849963 298 PRINTS PR01438 Universal stress protein signature 156 174 2.2E-18 T 13-10-2018 IPR006015 Universal stress protein A TOPB45_0467 f800104845a79e1e09c73268d8849963 298 PRINTS PR01438 Universal stress protein signature 251 263 2.2E-18 T 13-10-2018 IPR006015 Universal stress protein A TOPB45_0467 f800104845a79e1e09c73268d8849963 298 PRINTS PR01438 Universal stress protein signature 269 291 2.2E-18 T 13-10-2018 IPR006015 Universal stress protein A TOPB45_0467 f800104845a79e1e09c73268d8849963 298 Pfam PF00582 Universal stress protein family 156 290 6.1E-30 T 13-10-2018 IPR006016 UspA TOPB45_0467 f800104845a79e1e09c73268d8849963 298 Pfam PF00582 Universal stress protein family 7 149 2.0E-18 T 13-10-2018 IPR006016 UspA TOPB45_0467 f800104845a79e1e09c73268d8849963 298 SUPERFAMILY SSF52402 156 291 5.02E-35 T 13-10-2018 TOPB45_0467 f800104845a79e1e09c73268d8849963 298 SUPERFAMILY SSF52402 7 150 1.76E-18 T 13-10-2018 TOPB45_0467 f800104845a79e1e09c73268d8849963 298 Gene3D G3DSA:3.40.50.620 4 153 2.5E-19 T 13-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TOPB45_0467 f800104845a79e1e09c73268d8849963 298 Gene3D G3DSA:3.40.50.620 154 296 7.4E-36 T 13-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TOPB45_1061 d35fb117e67c03eb17ca2d8b0be8832d 294 Gene3D G3DSA:1.10.285.20 73 142 3.5E-22 T 13-10-2018 TOPB45_1061 d35fb117e67c03eb17ca2d8b0be8832d 294 Pfam PF01937 Protein of unknown function DUF89 6 284 8.1E-58 T 13-10-2018 IPR002791 Domain of unknown function DUF89 TOPB45_1061 d35fb117e67c03eb17ca2d8b0be8832d 294 SUPERFAMILY SSF111321 1 288 2.35E-89 T 13-10-2018 IPR036075 AF1104-like superfamily TOPB45_1061 d35fb117e67c03eb17ca2d8b0be8832d 294 Gene3D G3DSA:3.40.50.10880 143 292 2.6E-61 T 13-10-2018 TOPB45_1061 d35fb117e67c03eb17ca2d8b0be8832d 294 PIRSF PIRSF006593 1 293 3.7E-101 T 13-10-2018 IPR014444 Uncharacterised conserved protein UCP006593 TOPB45_0532 c8848f68e774c2629a507a17661cfe56 305 Pfam PF01687 Riboflavin kinase 182 304 3.4E-38 T 13-10-2018 IPR015865 Riboflavin kinase domain, bacterial/eukaryotic GO:0008531|GO:0009231 KEGG: 00740+2.7.1.26|MetaCyc: PWY-5523|MetaCyc: PWY-6168|MetaCyc: PWY-7863|Reactome: R-HSA-196843 TOPB45_0532 c8848f68e774c2629a507a17661cfe56 305 TIGRFAM TIGR00083 ribF: riboflavin biosynthesis protein RibF 16 304 4.5E-85 T 13-10-2018 IPR002606 Riboflavin kinase, bacterial GO:0003919|GO:0008531|GO:0009231 KEGG: 00740+2.7.1.26+2.7.7.2|MetaCyc: PWY-5523|MetaCyc: PWY-6167|MetaCyc: PWY-6168|MetaCyc: PWY-7863 TOPB45_0532 c8848f68e774c2629a507a17661cfe56 305 Gene3D G3DSA:2.40.30.30 184 305 1.9E-46 T 13-10-2018 IPR023465 Riboflavin kinase domain superfamily GO:0008531|GO:0009231 Reactome: R-HSA-196843 TOPB45_0532 c8848f68e774c2629a507a17661cfe56 305 SUPERFAMILY SSF82114 172 305 3.27E-47 T 13-10-2018 IPR023465 Riboflavin kinase domain superfamily GO:0008531|GO:0009231 Reactome: R-HSA-196843 TOPB45_0532 c8848f68e774c2629a507a17661cfe56 305 PIRSF PIRSF004491 3 305 5.7E-109 T 13-10-2018 IPR002606 Riboflavin kinase, bacterial GO:0003919|GO:0008531|GO:0009231 KEGG: 00740+2.7.1.26+2.7.7.2|MetaCyc: PWY-5523|MetaCyc: PWY-6167|MetaCyc: PWY-6168|MetaCyc: PWY-7863 TOPB45_0532 c8848f68e774c2629a507a17661cfe56 305 Gene3D G3DSA:3.40.50.620 5 183 1.0E-55 T 13-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TOPB45_0532 c8848f68e774c2629a507a17661cfe56 305 Pfam PF06574 FAD synthetase 14 164 1.4E-45 T 13-10-2018 IPR015864 FAD synthetase GO:0003919|GO:0009231 KEGG: 00740+2.7.1.26+2.7.7.2|MetaCyc: PWY-5523|MetaCyc: PWY-6167|MetaCyc: PWY-6168|MetaCyc: PWY-7863 TOPB45_0532 c8848f68e774c2629a507a17661cfe56 305 SMART SM00904 181 305 2.4E-55 T 13-10-2018 IPR015865 Riboflavin kinase domain, bacterial/eukaryotic GO:0008531|GO:0009231 KEGG: 00740+2.7.1.26|MetaCyc: PWY-5523|MetaCyc: PWY-6168|MetaCyc: PWY-7863|Reactome: R-HSA-196843 TOPB45_0532 c8848f68e774c2629a507a17661cfe56 305 SUPERFAMILY SSF52374 15 182 1.51E-36 T 13-10-2018 TOPB45_0442 d319d3a66d7e42a133719c53db5b5a5a 123 Pfam PF04126 Cyclophilin-like 1 120 1.3E-41 T 13-10-2018 IPR025658 Cyclophilin TM1367-like domain TOPB45_0442 d319d3a66d7e42a133719c53db5b5a5a 123 Gene3D G3DSA:2.40.100.20 1 122 8.8E-40 T 13-10-2018 TOPB45_0442 d319d3a66d7e42a133719c53db5b5a5a 123 SUPERFAMILY SSF50891 1 120 1.1E-28 T 13-10-2018 IPR029000 Cyclophilin-like domain superfamily TOPB45_0893 c93c06b5f9dc2a8706fbdd220d53831b 537 TIGRFAM TIGR01098 3A0109s03R: phosphate/phosphite/phosphonate ABC transporter, periplasmic binding protein 277 505 7.6E-34 T 13-10-2018 IPR005770 Phosphate/phosphite/phosphonate ABC transporter, periplasmic binding protein GO:0043190|GO:0055085 TOPB45_0893 c93c06b5f9dc2a8706fbdd220d53831b 537 SUPERFAMILY SSF53850 53 195 4.5E-13 T 13-10-2018 TOPB45_0893 c93c06b5f9dc2a8706fbdd220d53831b 537 Pfam PF12974 ABC transporter, phosphonate, periplasmic substrate-binding protein 287 526 1.1E-44 T 13-10-2018 TOPB45_0893 c93c06b5f9dc2a8706fbdd220d53831b 537 Pfam PF12974 ABC transporter, phosphonate, periplasmic substrate-binding protein 33 261 1.8E-27 T 13-10-2018 TOPB45_0893 c93c06b5f9dc2a8706fbdd220d53831b 537 Gene3D G3DSA:3.40.190.10 33 240 1.7E-21 T 13-10-2018 TOPB45_0893 c93c06b5f9dc2a8706fbdd220d53831b 537 SUPERFAMILY SSF53850 282 507 4.12E-20 T 13-10-2018 TOPB45_0893 c93c06b5f9dc2a8706fbdd220d53831b 537 Gene3D G3DSA:3.40.190.10 378 483 1.2E-37 T 13-10-2018 TOPB45_0893 c93c06b5f9dc2a8706fbdd220d53831b 537 Gene3D G3DSA:3.40.190.10 116 217 1.7E-21 T 13-10-2018 TOPB45_0893 c93c06b5f9dc2a8706fbdd220d53831b 537 Gene3D G3DSA:3.40.190.10 287 505 1.2E-37 T 13-10-2018 TOPB45_0688 c693d35efffdc94fa1b8b7e443d0bd81 645 TIGRFAM TIGR00418 thrS: threonine--tRNA ligase 75 633 2.3E-223 T 13-10-2018 IPR002320 Threonine-tRNA ligase, class IIa GO:0004829|GO:0005524|GO:0005737|GO:0006435 KEGG: 00970+6.1.1.3 TOPB45_0688 c693d35efffdc94fa1b8b7e443d0bd81 645 Pfam PF03129 Anticodon binding domain 546 632 1.0E-16 T 13-10-2018 IPR004154 Anticodon-binding TOPB45_0688 c693d35efffdc94fa1b8b7e443d0bd81 645 Pfam PF07973 Threonyl and Alanyl tRNA synthetase second additional domain 171 220 7.8E-14 T 13-10-2018 IPR012947 Threonyl/alanyl tRNA synthetase, SAD GO:0004812|GO:0005524|GO:0043039 TOPB45_0688 c693d35efffdc94fa1b8b7e443d0bd81 645 SUPERFAMILY SSF55186 67 242 1.57E-65 T 13-10-2018 IPR018163 Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily GO:0000166 TOPB45_0688 c693d35efffdc94fa1b8b7e443d0bd81 645 Gene3D G3DSA:3.30.930.10 224 534 7.6E-123 T 13-10-2018 TOPB45_0688 c693d35efffdc94fa1b8b7e443d0bd81 645 SMART SM00863 171 220 2.4E-24 T 13-10-2018 IPR012947 Threonyl/alanyl tRNA synthetase, SAD GO:0004812|GO:0005524|GO:0043039 TOPB45_0688 c693d35efffdc94fa1b8b7e443d0bd81 645 Gene3D G3DSA:3.40.50.800 535 643 5.2E-30 T 13-10-2018 IPR036621 Anticodon-binding domain superfamily TOPB45_0688 c693d35efffdc94fa1b8b7e443d0bd81 645 Gene3D G3DSA:3.30.54.20 133 188 2.4E-62 T 13-10-2018 TOPB45_0688 c693d35efffdc94fa1b8b7e443d0bd81 645 Hamap MF_00184 Threonine--tRNA ligase [thrS]. 69 637 35.171 T 13-10-2018 IPR002320 Threonine-tRNA ligase, class IIa GO:0004829|GO:0005524|GO:0005737|GO:0006435 KEGG: 00970+6.1.1.3 TOPB45_0688 c693d35efffdc94fa1b8b7e443d0bd81 645 SUPERFAMILY SSF52954 530 632 3.02E-27 T 13-10-2018 TOPB45_0688 c693d35efffdc94fa1b8b7e443d0bd81 645 SUPERFAMILY SSF55681 244 529 3.25E-96 T 13-10-2018 TOPB45_0688 c693d35efffdc94fa1b8b7e443d0bd81 645 Pfam PF00587 tRNA synthetase class II core domain (G, H, P, S and T) 326 532 4.6E-37 T 13-10-2018 IPR002314 Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) GO:0000166|GO:0004812|GO:0005524|GO:0006418 TOPB45_0688 c693d35efffdc94fa1b8b7e443d0bd81 645 PRINTS PR01047 Threonyl-tRNA synthetase signature 510 523 3.1E-51 T 13-10-2018 IPR002320 Threonine-tRNA ligase, class IIa GO:0004829|GO:0005524|GO:0005737|GO:0006435 KEGG: 00970+6.1.1.3 TOPB45_0688 c693d35efffdc94fa1b8b7e443d0bd81 645 PRINTS PR01047 Threonyl-tRNA synthetase signature 332 360 3.1E-51 T 13-10-2018 IPR002320 Threonine-tRNA ligase, class IIa GO:0004829|GO:0005524|GO:0005737|GO:0006435 KEGG: 00970+6.1.1.3 TOPB45_0688 c693d35efffdc94fa1b8b7e443d0bd81 645 PRINTS PR01047 Threonyl-tRNA synthetase signature 467 495 3.1E-51 T 13-10-2018 IPR002320 Threonine-tRNA ligase, class IIa GO:0004829|GO:0005524|GO:0005737|GO:0006435 KEGG: 00970+6.1.1.3 TOPB45_0688 c693d35efffdc94fa1b8b7e443d0bd81 645 PRINTS PR01047 Threonyl-tRNA synthetase signature 537 549 3.1E-51 T 13-10-2018 IPR002320 Threonine-tRNA ligase, class IIa GO:0004829|GO:0005524|GO:0005737|GO:0006435 KEGG: 00970+6.1.1.3 TOPB45_0688 c693d35efffdc94fa1b8b7e443d0bd81 645 PRINTS PR01047 Threonyl-tRNA synthetase signature 365 388 3.1E-51 T 13-10-2018 IPR002320 Threonine-tRNA ligase, class IIa GO:0004829|GO:0005524|GO:0005737|GO:0006435 KEGG: 00970+6.1.1.3 TOPB45_0688 c693d35efffdc94fa1b8b7e443d0bd81 645 Gene3D G3DSA:3.30.980.10 74 223 2.4E-62 T 13-10-2018 TOPB45_0627 2d28b625039599192ae28d870aff7175 132 Pfam PF00571 CBS domain 72 125 8.2E-9 T 13-10-2018 IPR000644 CBS domain TOPB45_0627 2d28b625039599192ae28d870aff7175 132 Pfam PF00571 CBS domain 5 60 1.7E-8 T 13-10-2018 IPR000644 CBS domain TOPB45_0627 2d28b625039599192ae28d870aff7175 132 Gene3D G3DSA:3.10.580.10 1 132 1.0E-29 T 13-10-2018 TOPB45_0627 2d28b625039599192ae28d870aff7175 132 SUPERFAMILY SSF54631 2 124 1.39E-27 T 13-10-2018 TOPB45_0627 2d28b625039599192ae28d870aff7175 132 SMART SM00116 12 61 4.2E-4 T 13-10-2018 IPR000644 CBS domain TOPB45_0627 2d28b625039599192ae28d870aff7175 132 SMART SM00116 79 126 0.0058 T 13-10-2018 IPR000644 CBS domain TOPB45_0669 4cfcff7880e2f693072ace4b17769bce 152 Pfam PF02580 D-Tyr-tRNA(Tyr) deacylase 2 144 9.6E-52 T 13-10-2018 IPR003732 D-aminoacyl-tRNA deacylase DTD GO:0002161|GO:0005737|GO:0051499 TOPB45_0669 4cfcff7880e2f693072ace4b17769bce 152 Hamap MF_00518 D-aminoacyl-tRNA deacylase [dtd]. 1 145 31.195 T 13-10-2018 IPR003732 D-aminoacyl-tRNA deacylase DTD GO:0002161|GO:0005737|GO:0051499 TOPB45_0669 4cfcff7880e2f693072ace4b17769bce 152 Gene3D G3DSA:3.50.80.10 1 146 1.2E-55 T 13-10-2018 IPR023509 D-aminoacyl-tRNA deacylase-like superfamily TOPB45_0669 4cfcff7880e2f693072ace4b17769bce 152 TIGRFAM TIGR00256 TIGR00256: D-tyrosyl-tRNA(Tyr) deacylase 1 144 3.5E-52 T 13-10-2018 IPR003732 D-aminoacyl-tRNA deacylase DTD GO:0002161|GO:0005737|GO:0051499 TOPB45_0669 4cfcff7880e2f693072ace4b17769bce 152 SUPERFAMILY SSF69500 1 144 5.49E-52 T 13-10-2018 IPR023509 D-aminoacyl-tRNA deacylase-like superfamily TOPB45_1496 0190287c2f8d295933d6566430366990 771 Gene3D G3DSA:3.30.190.20 134 233 9.4E-6 T 13-10-2018 TOPB45_1496 0190287c2f8d295933d6566430366990 771 SUPERFAMILY SSF52540 11 424 1.2E-26 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1496 0190287c2f8d295933d6566430366990 771 SUPERFAMILY SSF52540 486 746 1.08E-19 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1496 0190287c2f8d295933d6566430366990 771 Gene3D G3DSA:3.40.50.300 276 452 3.4E-39 T 13-10-2018 TOPB45_1496 0190287c2f8d295933d6566430366990 771 Gene3D G3DSA:3.40.50.300 6 88 7.9E-26 T 13-10-2018 TOPB45_1496 0190287c2f8d295933d6566430366990 771 Gene3D G3DSA:1.20.1580.10 547 702 8.1E-48 T 13-10-2018 TOPB45_1496 0190287c2f8d295933d6566430366990 771 Gene3D G3DSA:1.20.1580.10 89 117 7.9E-26 T 13-10-2018 TOPB45_1496 0190287c2f8d295933d6566430366990 771 Gene3D G3DSA:1.20.1580.10 255 275 3.4E-39 T 13-10-2018 TOPB45_1496 0190287c2f8d295933d6566430366990 771 Gene3D G3DSA:3.40.50.300 481 735 8.1E-48 T 13-10-2018 TOPB45_0569 b31d2a471c22d166357b688584f5b6c2 133 Gene3D G3DSA:1.20.120.50 1 131 1.3E-38 T 13-10-2018 IPR035938 Hemerythrin-like superfamily TOPB45_0569 b31d2a471c22d166357b688584f5b6c2 133 ProSitePatterns PS00550 Hemerythrin family signature. 58 81 - T 13-10-2018 IPR016131 Haemerythrin, iron-binding site GO:0046872 TOPB45_0569 b31d2a471c22d166357b688584f5b6c2 133 Pfam PF01814 Hemerythrin HHE cation binding domain 18 127 2.3E-11 T 13-10-2018 IPR012312 Haemerythrin-like Reactome: R-HSA-390471|Reactome: R-HSA-8951664|Reactome: R-HSA-917937|Reactome: R-HSA-983168 TOPB45_0569 b31d2a471c22d166357b688584f5b6c2 133 SUPERFAMILY SSF47188 1 127 5.76E-34 T 13-10-2018 IPR035938 Hemerythrin-like superfamily TOPB45_0569 b31d2a471c22d166357b688584f5b6c2 133 TIGRFAM TIGR02481 hemeryth_dom: hemerythrin-like metal-binding domain 5 127 7.9E-36 T 13-10-2018 IPR012827 Haemerythrin, metal-binding domain GO:0046872 TOPB45_0677 dde9516beb3b2fa35c0f2dc07c0ce59b 368 Pfam PF01950 Fructose-1,6-bisphosphatase 2 362 3.4E-186 T 13-10-2018 IPR002803 Fructose-1,6-bisphosphatase, class V KEGG: 00010+4.1.2.13+3.1.3.11|KEGG: 00030+4.1.2.13+3.1.3.11|KEGG: 00051+4.1.2.13+3.1.3.11|KEGG: 00680+4.1.2.13+3.1.3.11|KEGG: 00710+4.1.2.13+3.1.3.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-6142|MetaCyc: PWY-7385 TOPB45_0677 dde9516beb3b2fa35c0f2dc07c0ce59b 368 SUPERFAMILY SSF111249 2 362 3.01E-173 T 13-10-2018 IPR036076 Fructose-1,6-bisphosphatase, class V superfamily KEGG: 00010+3.1.3.11+4.1.2.13|KEGG: 00030+3.1.3.11+4.1.2.13|KEGG: 00051+3.1.3.11+4.1.2.13|KEGG: 00680+3.1.3.11+4.1.2.13|KEGG: 00710+3.1.3.11+4.1.2.13|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-6142|MetaCyc: PWY-7385 TOPB45_0677 dde9516beb3b2fa35c0f2dc07c0ce59b 368 ProDom PD014260 DIHYDROOROTATE DEHYDROGENASE THERMOPHILE-SPECIFIC TA1428 ST0318 BLL2851 16-BISPHOSPHATASE APE1109 PF0613 MJ0299 2 361 5.0E-165 T 13-10-2018 IPR002803 Fructose-1,6-bisphosphatase, class V KEGG: 00010+4.1.2.13+3.1.3.11|KEGG: 00030+4.1.2.13+3.1.3.11|KEGG: 00051+4.1.2.13+3.1.3.11|KEGG: 00680+4.1.2.13+3.1.3.11|KEGG: 00710+4.1.2.13+3.1.3.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-6142|MetaCyc: PWY-7385 TOPB45_0677 dde9516beb3b2fa35c0f2dc07c0ce59b 368 PIRSF PIRSF015647 1 368 3.5E-186 T 13-10-2018 IPR002803 Fructose-1,6-bisphosphatase, class V KEGG: 00010+4.1.2.13+3.1.3.11|KEGG: 00030+4.1.2.13+3.1.3.11|KEGG: 00051+4.1.2.13+3.1.3.11|KEGG: 00680+4.1.2.13+3.1.3.11|KEGG: 00710+4.1.2.13+3.1.3.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-6142|MetaCyc: PWY-7385 TOPB45_0677 dde9516beb3b2fa35c0f2dc07c0ce59b 368 Hamap MF_02067 Fructose-1,6-bisphosphate aldolase/phosphatase [fbp]. 1 362 59.262 T 13-10-2018 IPR002803 Fructose-1,6-bisphosphatase, class V KEGG: 00010+4.1.2.13+3.1.3.11|KEGG: 00030+4.1.2.13+3.1.3.11|KEGG: 00051+4.1.2.13+3.1.3.11|KEGG: 00680+4.1.2.13+3.1.3.11|KEGG: 00710+4.1.2.13+3.1.3.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-6142|MetaCyc: PWY-7385 TOPB45_1153 c40006f9be2a03b62c99794ff0774ac6 140 Gene3D G3DSA:3.30.70.1150 52 138 4.9E-35 T 13-10-2018 IPR027271 Acetolactate synthase/Transcription factor NikR, C-terminal TOPB45_1153 c40006f9be2a03b62c99794ff0774ac6 140 SUPERFAMILY SSF55021 54 134 4.12E-29 T 13-10-2018 TOPB45_1153 c40006f9be2a03b62c99794ff0774ac6 140 Hamap MF_00476 Nickel-responsive regulator [nikR]. 4 134 30.024 T 13-10-2018 IPR022988 Nickel-responsive transcriptional regulator NikR GO:0003677|GO:0006355|GO:0010045|GO:0016151 TOPB45_1153 c40006f9be2a03b62c99794ff0774ac6 140 Gene3D G3DSA:1.10.1220.10 5 50 5.2E-20 T 13-10-2018 IPR013321 Arc-type ribbon-helix-helix GO:0006355 TOPB45_1153 c40006f9be2a03b62c99794ff0774ac6 140 Pfam PF08753 NikR C terminal nickel binding domain 56 131 3.2E-33 T 13-10-2018 IPR014864 Transcription factor, NikR, nickel binding C-terminal TOPB45_1153 c40006f9be2a03b62c99794ff0774ac6 140 Pfam PF01402 Ribbon-helix-helix protein, copG family 6 43 2.7E-8 T 13-10-2018 IPR002145 Ribbon-helix-helix protein, CopG GO:0006355 TOPB45_1153 c40006f9be2a03b62c99794ff0774ac6 140 SUPERFAMILY SSF47598 4 50 2.59E-13 T 13-10-2018 IPR010985 Ribbon-helix-helix GO:0006355 TOPB45_0258 916ccbfc0eb598516052b548411202e1 308 Gene3D G3DSA:3.10.50.40 176 264 2.7E-40 T 13-10-2018 TOPB45_0258 916ccbfc0eb598516052b548411202e1 308 SUPERFAMILY SSF109998 26 206 2.0E-30 T 13-10-2018 IPR027304 Trigger factor/SurA domain superfamily TOPB45_0258 916ccbfc0eb598516052b548411202e1 308 Gene3D G3DSA:1.10.4030.30 28 281 2.7E-40 T 13-10-2018 TOPB45_0258 916ccbfc0eb598516052b548411202e1 308 Pfam PF13624 SurA N-terminal domain 6 144 8.1E-15 T 13-10-2018 TOPB45_0258 916ccbfc0eb598516052b548411202e1 308 Pfam PF13145 PPIC-type PPIASE domain 156 276 2.8E-15 T 13-10-2018 IPR000297 Peptidyl-prolyl cis-trans isomerase, PpiC-type GO:0003755 TOPB45_0258 916ccbfc0eb598516052b548411202e1 308 SUPERFAMILY SSF54534 184 264 2.62E-9 T 13-10-2018 TOPB45_1183 e3a8022f77bda87ef1df1164a566e150 714 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 1 155 6.1E-14 T 13-10-2018 IPR005225 Small GTP-binding protein domain GO:0005525 TOPB45_1183 e3a8022f77bda87ef1df1164a566e150 714 Pfam PF02421 Ferrous iron transport protein B 4 158 5.2E-62 T 13-10-2018 IPR030389 FeoB-type guanine nucleotide-binding (G) domain GO:0005525 TOPB45_1183 e3a8022f77bda87ef1df1164a566e150 714 Gene3D G3DSA:3.40.50.300 4 183 3.8E-44 T 13-10-2018 TOPB45_1183 e3a8022f77bda87ef1df1164a566e150 714 SUPERFAMILY SSF52540 4 176 9.85E-41 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1183 e3a8022f77bda87ef1df1164a566e150 714 Pfam PF07670 Nucleoside recognition 353 446 1.3E-12 T 13-10-2018 IPR011642 Nucleoside transporter/FeoB GTPase, Gate domain Reactome: R-HSA-83936 TOPB45_1183 e3a8022f77bda87ef1df1164a566e150 714 Pfam PF07670 Nucleoside recognition 514 682 1.3E-27 T 13-10-2018 IPR011642 Nucleoside transporter/FeoB GTPase, Gate domain Reactome: R-HSA-83936 TOPB45_1183 e3a8022f77bda87ef1df1164a566e150 714 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 6 26 2.3E-5 T 13-10-2018 IPR006073 GTP binding domain GO:0005525 TOPB45_1183 e3a8022f77bda87ef1df1164a566e150 714 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 27 45 2.3E-5 T 13-10-2018 IPR006073 GTP binding domain GO:0005525 TOPB45_1183 e3a8022f77bda87ef1df1164a566e150 714 TIGRFAM TIGR00437 feoB: ferrous iron transport protein B 10 681 4.1E-188 T 13-10-2018 IPR003373 Ferrous iron transport protein B GO:0005525|GO:0015093|GO:0015684|GO:0016021 TOPB45_1183 e3a8022f77bda87ef1df1164a566e150 714 Pfam PF07664 Ferrous iron transport protein B C terminus 457 509 1.6E-21 T 13-10-2018 IPR011640 Ferrous iron transport protein B, C-terminal GO:0015093|GO:0015684|GO:0016021 TOPB45_1546 79349a3ffcbc9ecf228e61cbc6665c2a 473 Pfam PF02874 ATP synthase alpha/beta family, beta-barrel domain 10 82 6.6E-20 T 13-10-2018 IPR004100 ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain GO:0046034|GO:1902600 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7980 TOPB45_1546 79349a3ffcbc9ecf228e61cbc6665c2a 473 TIGRFAM TIGR01039 atpD: ATP synthase F1, beta subunit 7 470 3.7E-241 T 13-10-2018 IPR005722 ATP synthase, F1 complex, beta subunit GO:0015986|GO:0045261|GO:0046933 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7980|Reactome: R-HSA-1268020|Reactome: R-HSA-163210|Reactome: R-HSA-2151201|Reactome: R-HSA-8949613 TOPB45_1546 79349a3ffcbc9ecf228e61cbc6665c2a 473 SUPERFAMILY SSF52540 87 357 2.88E-86 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1546 79349a3ffcbc9ecf228e61cbc6665c2a 473 Gene3D G3DSA:2.40.10.170 6 84 4.8E-27 T 13-10-2018 TOPB45_1546 79349a3ffcbc9ecf228e61cbc6665c2a 473 Pfam PF00006 ATP synthase alpha/beta family, nucleotide-binding domain 139 352 1.1E-62 T 13-10-2018 IPR000194 ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain GO:0005524 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7980 TOPB45_1546 79349a3ffcbc9ecf228e61cbc6665c2a 473 SUPERFAMILY SSF50615 7 84 5.69E-24 T 13-10-2018 IPR036121 ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily GO:0046034|GO:1902600 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7980 TOPB45_1546 79349a3ffcbc9ecf228e61cbc6665c2a 473 Gene3D G3DSA:3.40.50.300 85 354 9.0E-109 T 13-10-2018 TOPB45_1546 79349a3ffcbc9ecf228e61cbc6665c2a 473 Hamap MF_01347 ATP synthase subunit beta [atpB]. 5 470 55.032 T 13-10-2018 IPR005722 ATP synthase, F1 complex, beta subunit GO:0015986|GO:0045261|GO:0046933 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7980|Reactome: R-HSA-1268020|Reactome: R-HSA-163210|Reactome: R-HSA-2151201|Reactome: R-HSA-8949613 TOPB45_1546 79349a3ffcbc9ecf228e61cbc6665c2a 473 Gene3D G3DSA:1.10.1140.10 355 473 2.5E-58 T 13-10-2018 IPR024034 ATPase, F1/V1 complex, beta/alpha subunit, C-terminal KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7980 TOPB45_1546 79349a3ffcbc9ecf228e61cbc6665c2a 473 ProSitePatterns PS00152 ATP synthase alpha and beta subunits signature. 343 352 - T 13-10-2018 IPR020003 ATPase, alpha/beta subunit, nucleotide-binding domain, active site GO:0005524 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7980 TOPB45_1546 79349a3ffcbc9ecf228e61cbc6665c2a 473 SUPERFAMILY SSF47917 355 470 3.4E-53 T 13-10-2018 TOPB45_0761 f8c11a566d9e2b1a96b168f25c277376 65 Pfam PF00831 Ribosomal L29 protein 5 60 4.7E-26 T 13-10-2018 IPR001854 Ribosomal protein L29/L35 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0761 f8c11a566d9e2b1a96b168f25c277376 65 SUPERFAMILY SSF46561 1 63 1.01E-23 T 13-10-2018 IPR036049 Ribosomal protein L29/L35 superfamily GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0761 f8c11a566d9e2b1a96b168f25c277376 65 TIGRFAM TIGR00012 L29: ribosomal protein uL29 5 60 6.6E-24 T 13-10-2018 IPR001854 Ribosomal protein L29/L35 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0761 f8c11a566d9e2b1a96b168f25c277376 65 Gene3D G3DSA:1.10.287.310 1 65 2.7E-28 T 13-10-2018 TOPB45_0761 f8c11a566d9e2b1a96b168f25c277376 65 ProSitePatterns PS00579 Ribosomal protein L29 signature. 39 53 - T 13-10-2018 IPR018254 Ribosomal protein L29, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0761 f8c11a566d9e2b1a96b168f25c277376 65 Hamap MF_00374 50S ribosomal protein L29 [rpmC]. 1 60 18.046 T 13-10-2018 IPR001854 Ribosomal protein L29/L35 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0665 58ceebf962b09ceaa5865facb9a1b026 461 PRINTS PR01590 FIS bacterial regulatory protein HTH signature 430 450 5.2E-6 T 13-10-2018 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 TOPB45_0665 58ceebf962b09ceaa5865facb9a1b026 461 PRINTS PR01590 FIS bacterial regulatory protein HTH signature 413 430 5.2E-6 T 13-10-2018 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 TOPB45_0665 58ceebf962b09ceaa5865facb9a1b026 461 SUPERFAMILY SSF52540 141 385 9.8E-77 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0665 58ceebf962b09ceaa5865facb9a1b026 461 Pfam PF00072 Response regulator receiver domain 4 113 2.2E-25 T 13-10-2018 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TOPB45_0665 58ceebf962b09ceaa5865facb9a1b026 461 Gene3D G3DSA:3.40.50.2300 3 121 2.5E-31 T 13-10-2018 TOPB45_0665 58ceebf962b09ceaa5865facb9a1b026 461 Gene3D G3DSA:1.10.10.60 396 451 1.6E-11 T 13-10-2018 TOPB45_0665 58ceebf962b09ceaa5865facb9a1b026 461 SUPERFAMILY SSF52172 1 187 2.13E-38 T 13-10-2018 IPR011006 CheY-like superfamily TOPB45_0665 58ceebf962b09ceaa5865facb9a1b026 461 SMART SM00382 162 305 6.2E-13 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_0665 58ceebf962b09ceaa5865facb9a1b026 461 Gene3D G3DSA:1.10.8.60 313 391 6.3E-29 T 13-10-2018 TOPB45_0665 58ceebf962b09ceaa5865facb9a1b026 461 Pfam PF02954 Bacterial regulatory protein, Fis family 408 447 1.3E-12 T 13-10-2018 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 TOPB45_0665 58ceebf962b09ceaa5865facb9a1b026 461 ProSitePatterns PS00675 Sigma-54 interaction domain ATP-binding region A signature. 166 179 - T 13-10-2018 IPR025662 Sigma-54 interaction domain, ATP-binding site 1 TOPB45_0665 58ceebf962b09ceaa5865facb9a1b026 461 SMART SM00448 2 113 1.2E-26 T 13-10-2018 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TOPB45_0665 58ceebf962b09ceaa5865facb9a1b026 461 ProSitePatterns PS00676 Sigma-54 interaction domain ATP-binding region B signature. 228 243 - T 13-10-2018 IPR025943 Sigma-54 interaction domain, ATP-binding site 2 TOPB45_0665 58ceebf962b09ceaa5865facb9a1b026 461 Gene3D G3DSA:3.40.50.300 127 312 1.4E-70 T 13-10-2018 TOPB45_0665 58ceebf962b09ceaa5865facb9a1b026 461 SUPERFAMILY SSF46689 355 449 5.38E-9 T 13-10-2018 IPR009057 Homeobox-like domain superfamily GO:0003677 TOPB45_0665 58ceebf962b09ceaa5865facb9a1b026 461 Pfam PF00158 Sigma-54 interaction domain 142 309 2.1E-74 T 13-10-2018 IPR002078 RNA polymerase sigma factor 54 interaction domain GO:0005524|GO:0006355|GO:0008134 TOPB45_0503 ea41e962ec51024a7573b0baab092fe8 356 Gene3D G3DSA:3.30.470.10 23 350 5.3E-139 T 13-10-2018 TOPB45_0503 ea41e962ec51024a7573b0baab092fe8 356 PIRSF PIRSF006468 1 356 1.4E-133 T 13-10-2018 IPR005786 Branched-chain amino acid aminotransferase II GO:0004084|GO:0009081 KEGG: 00270+2.6.1.42|KEGG: 00280+2.6.1.42|KEGG: 00290+2.6.1.42|KEGG: 00770+2.6.1.42|KEGG: 00966+2.6.1.42|MetaCyc: PWY-5057|MetaCyc: PWY-5076|MetaCyc: PWY-5078|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-5108|MetaCyc: PWY-7767|Reactome: R-HSA-70895 TOPB45_0503 ea41e962ec51024a7573b0baab092fe8 356 Pfam PF01063 Amino-transferase class IV 68 311 1.1E-40 T 13-10-2018 IPR001544 Aminotransferase class IV GO:0003824 Reactome: R-HSA-70895 TOPB45_0503 ea41e962ec51024a7573b0baab092fe8 356 SUPERFAMILY SSF56752 16 351 1.05E-115 T 13-10-2018 IPR036038 Aminotransferase-like, PLP-dependent enzymes GO:0003824 Reactome: R-HSA-70895 TOPB45_0503 ea41e962ec51024a7573b0baab092fe8 356 ProSitePatterns PS00770 Aminotransferases class-IV signature. 231 260 - T 13-10-2018 IPR018300 Aminotransferase, class IV, conserved site GO:0003824 Reactome: R-HSA-70895 TOPB45_0503 ea41e962ec51024a7573b0baab092fe8 356 Gene3D G3DSA:3.20.10.10 169 337 5.3E-139 T 13-10-2018 TOPB45_0503 ea41e962ec51024a7573b0baab092fe8 356 TIGRFAM TIGR01123 ilvE_II: branched-chain amino acid aminotransferase 42 353 1.2E-121 T 13-10-2018 IPR005786 Branched-chain amino acid aminotransferase II GO:0004084|GO:0009081 KEGG: 00270+2.6.1.42|KEGG: 00280+2.6.1.42|KEGG: 00290+2.6.1.42|KEGG: 00770+2.6.1.42|KEGG: 00966+2.6.1.42|MetaCyc: PWY-5057|MetaCyc: PWY-5076|MetaCyc: PWY-5078|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-5108|MetaCyc: PWY-7767|Reactome: R-HSA-70895 TOPB45_1218 24455ad989d8ecd1b4f5c08748ec5ca3 331 Pfam PF07687 Peptidase dimerisation domain 147 230 7.7E-14 T 13-10-2018 IPR011650 Peptidase M20, dimerisation domain TOPB45_1218 24455ad989d8ecd1b4f5c08748ec5ca3 331 Gene3D G3DSA:3.40.630.10 10 316 1.2E-60 T 13-10-2018 TOPB45_1218 24455ad989d8ecd1b4f5c08748ec5ca3 331 SUPERFAMILY SSF53187 10 320 4.65E-36 T 13-10-2018 TOPB45_1218 24455ad989d8ecd1b4f5c08748ec5ca3 331 Gene3D G3DSA:3.30.70.360 147 243 1.2E-60 T 13-10-2018 TOPB45_1218 24455ad989d8ecd1b4f5c08748ec5ca3 331 Pfam PF01546 Peptidase family M20/M25/M40 59 320 7.2E-17 T 13-10-2018 IPR002933 Peptidase M20 GO:0016787 TOPB45_1218 24455ad989d8ecd1b4f5c08748ec5ca3 331 SUPERFAMILY SSF55031 148 229 1.17E-10 T 13-10-2018 IPR036264 Bacterial exopeptidase dimerisation domain TOPB45_0680 0b1bd7e76d0355a84a19e718d831810d 217 Gene3D G3DSA:3.30.1150.10 117 212 8.3E-9 T 13-10-2018 TOPB45_0680 0b1bd7e76d0355a84a19e718d831810d 217 Pfam PF13103 TonB C terminal 128 198 3.4E-11 T 13-10-2018 TOPB45_0680 0b1bd7e76d0355a84a19e718d831810d 217 SUPERFAMILY SSF74653 108 210 2.09E-9 T 13-10-2018 TOPB45_1382 074881046f478192834f7142f8b5cdeb 229 Hamap MF_00238 Cytidylate kinase [cmk]. 5 228 26.892 T 13-10-2018 IPR003136 Cytidylate kinase GO:0004127|GO:0005524|GO:0006139 KEGG: 00240+2.7.4.25|MetaCyc: PWY-7205 TOPB45_1382 074881046f478192834f7142f8b5cdeb 229 SUPERFAMILY SSF52540 1 229 3.85E-38 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1382 074881046f478192834f7142f8b5cdeb 229 TIGRFAM TIGR00017 cmk: cytidylate kinase 6 226 2.2E-58 T 13-10-2018 IPR003136 Cytidylate kinase GO:0004127|GO:0005524|GO:0006139 KEGG: 00240+2.7.4.25|MetaCyc: PWY-7205 TOPB45_1382 074881046f478192834f7142f8b5cdeb 229 Gene3D G3DSA:3.40.50.300 1 229 1.7E-70 T 13-10-2018 TOPB45_1382 074881046f478192834f7142f8b5cdeb 229 Pfam PF02224 Cytidylate kinase 7 229 2.9E-62 T 13-10-2018 IPR011994 Cytidylate kinase domain GO:0004127|GO:0005524|GO:0006139 KEGG: 00240+2.7.4.25|MetaCyc: PWY-7205 TOPB45_0004 972fda4b0aafb9e81adf4b70b34dfaba 194 Gene3D G3DSA:1.10.530.10 52 194 2.6E-44 T 13-10-2018 TOPB45_0004 972fda4b0aafb9e81adf4b70b34dfaba 194 Pfam PF01464 Transglycosylase SLT domain 76 179 5.8E-30 T 13-10-2018 IPR008258 Transglycosylase SLT domain 1 TOPB45_0004 972fda4b0aafb9e81adf4b70b34dfaba 194 ProSitePatterns PS00922 Prokaryotic transglycosylases signature. 93 121 - T 13-10-2018 IPR000189 Prokaryotic transglycosylase, active site GO:0000270|GO:0008933|GO:0016020 TOPB45_0004 972fda4b0aafb9e81adf4b70b34dfaba 194 SUPERFAMILY SSF53955 73 194 7.04E-44 T 13-10-2018 IPR023346 Lysozyme-like domain superfamily TOPB45_0876 102da41bb482e4860973a1a248e314be 1395 TIGRFAM TIGR00241 CoA_E_activ: putative CoA-substrate-specific enzyme activase 323 574 2.0E-54 T 13-10-2018 IPR008275 CoA enzyme activase TOPB45_0876 102da41bb482e4860973a1a248e314be 1395 TIGRFAM TIGR00241 CoA_E_activ: putative CoA-substrate-specific enzyme activase 4 257 3.0E-48 T 13-10-2018 IPR008275 CoA enzyme activase TOPB45_0876 102da41bb482e4860973a1a248e314be 1395 Pfam PF09989 CoA enzyme activase uncharacterised domain (DUF2229) 670 886 3.4E-52 T 13-10-2018 IPR018709 CoA enzyme activase, domain of unknown function DUF2229 TOPB45_0876 102da41bb482e4860973a1a248e314be 1395 Gene3D G3DSA:3.30.420.40 95 244 1.3E-82 T 13-10-2018 TOPB45_0876 102da41bb482e4860973a1a248e314be 1395 Gene3D G3DSA:3.30.420.40 324 575 9.3E-94 T 13-10-2018 TOPB45_0876 102da41bb482e4860973a1a248e314be 1395 Pfam PF01869 BadF/BadG/BcrA/BcrD ATPase family 4 259 2.9E-36 T 13-10-2018 IPR002731 ATPase, BadF/BadG/BcrA/BcrD type Reactome: R-HSA-446210 TOPB45_0876 102da41bb482e4860973a1a248e314be 1395 Pfam PF01869 BadF/BadG/BcrA/BcrD ATPase family 324 575 1.4E-43 T 13-10-2018 IPR002731 ATPase, BadF/BadG/BcrA/BcrD type Reactome: R-HSA-446210 TOPB45_0876 102da41bb482e4860973a1a248e314be 1395 Gene3D G3DSA:3.30.420.40 418 558 9.3E-94 T 13-10-2018 TOPB45_0876 102da41bb482e4860973a1a248e314be 1395 SUPERFAMILY SSF53067 3 258 2.09E-43 T 13-10-2018 TOPB45_0876 102da41bb482e4860973a1a248e314be 1395 Gene3D G3DSA:3.30.420.40 4 258 1.3E-82 T 13-10-2018 TOPB45_0876 102da41bb482e4860973a1a248e314be 1395 SUPERFAMILY SSF53067 323 575 3.85E-45 T 13-10-2018 TOPB45_0895 6e0a03c0b26fa4fad7d6edc053411064 450 SUPERFAMILY SSF46689 350 441 1.43E-13 T 13-10-2018 IPR009057 Homeobox-like domain superfamily GO:0003677 TOPB45_0895 6e0a03c0b26fa4fad7d6edc053411064 450 SMART SM00448 3 114 4.0E-35 T 13-10-2018 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TOPB45_0895 6e0a03c0b26fa4fad7d6edc053411064 450 Pfam PF00072 Response regulator receiver domain 5 114 1.4E-26 T 13-10-2018 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TOPB45_0895 6e0a03c0b26fa4fad7d6edc053411064 450 Pfam PF02954 Bacterial regulatory protein, Fis family 401 437 2.9E-15 T 13-10-2018 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 TOPB45_0895 6e0a03c0b26fa4fad7d6edc053411064 450 PRINTS PR01590 FIS bacterial regulatory protein HTH signature 405 422 4.5E-12 T 13-10-2018 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 TOPB45_0895 6e0a03c0b26fa4fad7d6edc053411064 450 PRINTS PR01590 FIS bacterial regulatory protein HTH signature 422 442 4.5E-12 T 13-10-2018 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 TOPB45_0895 6e0a03c0b26fa4fad7d6edc053411064 450 SMART SM00382 157 300 1.2E-14 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_0895 6e0a03c0b26fa4fad7d6edc053411064 450 ProSitePatterns PS00675 Sigma-54 interaction domain ATP-binding region A signature. 161 174 - T 13-10-2018 IPR025662 Sigma-54 interaction domain, ATP-binding site 1 TOPB45_0895 6e0a03c0b26fa4fad7d6edc053411064 450 ProSitePatterns PS00688 Sigma-54 interaction domain C-terminal part signature. 350 359 - T 13-10-2018 IPR025944 Sigma-54 interaction domain, conserved site TOPB45_0895 6e0a03c0b26fa4fad7d6edc053411064 450 SUPERFAMILY SSF52172 3 182 6.55E-45 T 13-10-2018 IPR011006 CheY-like superfamily TOPB45_0895 6e0a03c0b26fa4fad7d6edc053411064 450 Gene3D G3DSA:1.10.10.60 380 442 2.4E-18 T 13-10-2018 TOPB45_0895 6e0a03c0b26fa4fad7d6edc053411064 450 Gene3D G3DSA:3.40.50.300 124 308 6.7E-69 T 13-10-2018 TOPB45_0895 6e0a03c0b26fa4fad7d6edc053411064 450 Pfam PF00158 Sigma-54 interaction domain 137 304 7.8E-72 T 13-10-2018 IPR002078 RNA polymerase sigma factor 54 interaction domain GO:0005524|GO:0006355|GO:0008134 TOPB45_0895 6e0a03c0b26fa4fad7d6edc053411064 450 SUPERFAMILY SSF52540 136 380 1.53E-78 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0895 6e0a03c0b26fa4fad7d6edc053411064 450 Gene3D G3DSA:3.40.50.2300 4 123 3.9E-37 T 13-10-2018 TOPB45_0895 6e0a03c0b26fa4fad7d6edc053411064 450 Gene3D G3DSA:1.10.8.60 309 379 1.4E-29 T 13-10-2018 TOPB45_0622 59221f12af5614a1edf43e1b692016d8 218 SUPERFAMILY SSF63380 92 198 5.53E-34 T 13-10-2018 IPR017938 Riboflavin synthase-like beta-barrel TOPB45_0622 59221f12af5614a1edf43e1b692016d8 218 TIGRFAM TIGR00187 ribE: riboflavin synthase, alpha subunit 1 199 4.1E-66 T 13-10-2018 IPR001783 Lumazine-binding protein KEGG: 00740+2.5.1.9|MetaCyc: PWY-6167|MetaCyc: PWY-6168 TOPB45_0622 59221f12af5614a1edf43e1b692016d8 218 Pfam PF00677 Lumazine binding domain 99 183 1.1E-23 T 13-10-2018 IPR026017 Lumazine-binding domain KEGG: 00740+2.5.1.9|MetaCyc: PWY-6167|MetaCyc: PWY-6168 TOPB45_0622 59221f12af5614a1edf43e1b692016d8 218 Pfam PF00677 Lumazine binding domain 3 86 5.0E-21 T 13-10-2018 IPR026017 Lumazine-binding domain KEGG: 00740+2.5.1.9|MetaCyc: PWY-6167|MetaCyc: PWY-6168 TOPB45_0622 59221f12af5614a1edf43e1b692016d8 218 SUPERFAMILY SSF63380 1 92 4.42E-26 T 13-10-2018 IPR017938 Riboflavin synthase-like beta-barrel TOPB45_0622 59221f12af5614a1edf43e1b692016d8 218 Gene3D G3DSA:2.40.30.20 1 88 9.9E-27 T 13-10-2018 IPR023366 ATP synthase subunit alpha, N-terminal domain-like superfamily KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7980 TOPB45_0622 59221f12af5614a1edf43e1b692016d8 218 PIRSF PIRSF000498 1 210 2.5E-70 T 13-10-2018 IPR001783 Lumazine-binding protein KEGG: 00740+2.5.1.9|MetaCyc: PWY-6167|MetaCyc: PWY-6168 TOPB45_0622 59221f12af5614a1edf43e1b692016d8 218 Gene3D G3DSA:2.40.30.20 101 202 6.3E-33 T 13-10-2018 IPR023366 ATP synthase subunit alpha, N-terminal domain-like superfamily KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7980 TOPB45_0099 27a340df40592f647cfd81a379bcdd5d 171 Pfam PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 48 155 5.0E-28 T 13-10-2018 IPR006137 NADH:ubiquinone oxidoreductase-like, 20kDa subunit GO:0051536|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_0099 27a340df40592f647cfd81a379bcdd5d 171 Hamap MF_01356 NAD(P)H-quinone oxidoreductase subunit K, chloroplastic [ndhK]. 1 161 42.904 T 13-10-2018 IPR006138 NADH-ubiquinone oxidoreductase, 20 Kd subunit GO:0008137|GO:0048038|GO:0051539|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_0099 27a340df40592f647cfd81a379bcdd5d 171 TIGRFAM TIGR01957 nuoB_fam: NADH-quinone oxidoreductase, B subunit 22 162 1.4E-72 T 13-10-2018 IPR006138 NADH-ubiquinone oxidoreductase, 20 Kd subunit GO:0008137|GO:0048038|GO:0051539|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_0099 27a340df40592f647cfd81a379bcdd5d 171 Gene3D G3DSA:3.40.50.12280 11 169 7.6E-77 T 13-10-2018 TOPB45_0099 27a340df40592f647cfd81a379bcdd5d 171 SUPERFAMILY SSF56770 21 164 2.62E-68 T 13-10-2018 TOPB45_0623 decc3d1f894c7e20960a8013d64f88ce 362 Pfam PF00144 Beta-lactamase 23 340 2.7E-24 T 13-10-2018 IPR001466 Beta-lactamase-related TOPB45_0623 decc3d1f894c7e20960a8013d64f88ce 362 SUPERFAMILY SSF56601 7 347 2.08E-42 T 13-10-2018 IPR012338 Beta-lactamase/transpeptidase-like TOPB45_0623 decc3d1f894c7e20960a8013d64f88ce 362 Gene3D G3DSA:3.40.710.10 4 356 2.4E-42 T 13-10-2018 TOPB45_0650 8f484bec5ffe61df27f76aaf5d09e574 82 Gene3D G3DSA:2.20.28.30 1 45 1.6E-5 T 13-10-2018 TOPB45_0650 8f484bec5ffe61df27f76aaf5d09e574 82 Pfam PF09723 Zinc ribbon domain 1 42 4.5E-14 T 13-10-2018 IPR013429 Putative regulatory protein, FmdB, Zinc ribbon domain TOPB45_0650 8f484bec5ffe61df27f76aaf5d09e574 82 TIGRFAM TIGR02605 CxxC_CxxC_SSSS: putative regulatory protein, FmdB family 1 52 1.7E-16 T 13-10-2018 IPR013429 Putative regulatory protein, FmdB, Zinc ribbon domain TOPB45_0650 8f484bec5ffe61df27f76aaf5d09e574 82 SMART SM00834 1 43 6.4E-14 T 13-10-2018 IPR013429 Putative regulatory protein, FmdB, Zinc ribbon domain TOPB45_0773 0d9702d3523b78e8435e7ef82419bf70 436 SUPERFAMILY SSF103491 5 419 8.89E-124 T 13-10-2018 IPR023201 SecY domain superfamily Reactome: R-HSA-1236974|Reactome: R-HSA-1799339|Reactome: R-HSA-381038 TOPB45_0773 0d9702d3523b78e8435e7ef82419bf70 436 Pfam PF00344 SecY translocase 73 412 8.0E-115 T 13-10-2018 IPR002208 SecY/SEC61-alpha family GO:0015031|GO:0016020 Reactome: R-HSA-1236974|Reactome: R-HSA-1799339|Reactome: R-HSA-381038 TOPB45_0773 0d9702d3523b78e8435e7ef82419bf70 436 Hamap MF_01465 Protein translocase subunit SecY [secY]. 7 428 29.229 T 13-10-2018 IPR026593 Protein translocase subunit SecY TOPB45_0773 0d9702d3523b78e8435e7ef82419bf70 436 PIRSF PIRSF004557 3 434 3.2E-119 T 13-10-2018 IPR002208 SecY/SEC61-alpha family GO:0015031|GO:0016020 Reactome: R-HSA-1236974|Reactome: R-HSA-1799339|Reactome: R-HSA-381038 TOPB45_0773 0d9702d3523b78e8435e7ef82419bf70 436 TIGRFAM TIGR00967 3a0501s007: preprotein translocase, SecY subunit 17 423 1.7E-119 T 13-10-2018 IPR002208 SecY/SEC61-alpha family GO:0015031|GO:0016020 Reactome: R-HSA-1236974|Reactome: R-HSA-1799339|Reactome: R-HSA-381038 TOPB45_0773 0d9702d3523b78e8435e7ef82419bf70 436 PRINTS PR00303 Preprotein translocase SecY subunit signature 179 202 1.2E-85 T 13-10-2018 TOPB45_0773 0d9702d3523b78e8435e7ef82419bf70 436 PRINTS PR00303 Preprotein translocase SecY subunit signature 397 415 1.2E-85 T 13-10-2018 TOPB45_0773 0d9702d3523b78e8435e7ef82419bf70 436 PRINTS PR00303 Preprotein translocase SecY subunit signature 153 178 1.2E-85 T 13-10-2018 TOPB45_0773 0d9702d3523b78e8435e7ef82419bf70 436 PRINTS PR00303 Preprotein translocase SecY subunit signature 113 136 1.2E-85 T 13-10-2018 TOPB45_0773 0d9702d3523b78e8435e7ef82419bf70 436 PRINTS PR00303 Preprotein translocase SecY subunit signature 310 332 1.2E-85 T 13-10-2018 TOPB45_0773 0d9702d3523b78e8435e7ef82419bf70 436 PRINTS PR00303 Preprotein translocase SecY subunit signature 271 290 1.2E-85 T 13-10-2018 TOPB45_0773 0d9702d3523b78e8435e7ef82419bf70 436 PRINTS PR00303 Preprotein translocase SecY subunit signature 72 92 1.2E-85 T 13-10-2018 TOPB45_0773 0d9702d3523b78e8435e7ef82419bf70 436 PRINTS PR00303 Preprotein translocase SecY subunit signature 365 383 1.2E-85 T 13-10-2018 TOPB45_0773 0d9702d3523b78e8435e7ef82419bf70 436 PRINTS PR00303 Preprotein translocase SecY subunit signature 20 38 1.2E-85 T 13-10-2018 TOPB45_0773 0d9702d3523b78e8435e7ef82419bf70 436 Gene3D G3DSA:1.10.3370.10 5 424 1.9E-159 T 13-10-2018 IPR023201 SecY domain superfamily Reactome: R-HSA-1236974|Reactome: R-HSA-1799339|Reactome: R-HSA-381038 TOPB45_0773 0d9702d3523b78e8435e7ef82419bf70 436 ProSitePatterns PS00755 Protein secY signature 1. 73 92 - T 13-10-2018 IPR030659 SecY conserved site Reactome: R-HSA-1236974|Reactome: R-HSA-1799339|Reactome: R-HSA-381038 TOPB45_0773 0d9702d3523b78e8435e7ef82419bf70 436 ProSitePatterns PS00756 Protein secY signature 2. 172 189 - T 13-10-2018 IPR030659 SecY conserved site Reactome: R-HSA-1236974|Reactome: R-HSA-1799339|Reactome: R-HSA-381038 TOPB45_0894 2ed092a7a6571576b75818fb2e49646a 543 Gene3D G3DSA:3.30.565.10 393 542 5.5E-48 T 13-10-2018 IPR036890 Histidine kinase/HSP90-like ATPase superfamily TOPB45_0894 2ed092a7a6571576b75818fb2e49646a 543 SMART SM00388 328 393 1.7E-12 T 13-10-2018 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TOPB45_0894 2ed092a7a6571576b75818fb2e49646a 543 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 436 538 1.2E-24 T 13-10-2018 IPR003594 Histidine kinase/HSP90-like ATPase TOPB45_0894 2ed092a7a6571576b75818fb2e49646a 543 PRINTS PR00344 Bacterial sensor protein C-terminal signature 501 519 2.5E-20 T 13-10-2018 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TOPB45_0894 2ed092a7a6571576b75818fb2e49646a 543 PRINTS PR00344 Bacterial sensor protein C-terminal signature 490 500 2.5E-20 T 13-10-2018 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TOPB45_0894 2ed092a7a6571576b75818fb2e49646a 543 PRINTS PR00344 Bacterial sensor protein C-terminal signature 472 486 2.5E-20 T 13-10-2018 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TOPB45_0894 2ed092a7a6571576b75818fb2e49646a 543 PRINTS PR00344 Bacterial sensor protein C-terminal signature 525 538 2.5E-20 T 13-10-2018 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TOPB45_0894 2ed092a7a6571576b75818fb2e49646a 543 Gene3D G3DSA:1.10.287.130 312 390 7.0E-17 T 13-10-2018 TOPB45_0894 2ed092a7a6571576b75818fb2e49646a 543 SUPERFAMILY SSF55874 384 539 2.88E-43 T 13-10-2018 IPR036890 Histidine kinase/HSP90-like ATPase superfamily TOPB45_0894 2ed092a7a6571576b75818fb2e49646a 543 SUPERFAMILY SSF47384 324 389 4.9E-13 T 13-10-2018 IPR036097 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily GO:0000155|GO:0007165 TOPB45_0894 2ed092a7a6571576b75818fb2e49646a 543 Pfam PF17203 Single cache domain 3 91 181 2.4E-7 T 13-10-2018 IPR033463 Single cache domain 3 TOPB45_0894 2ed092a7a6571576b75818fb2e49646a 543 SUPERFAMILY SSF103190 92 180 2.55E-6 T 13-10-2018 IPR029151 Periplasmic sensor-like domain superfamily TOPB45_0894 2ed092a7a6571576b75818fb2e49646a 543 SMART SM00387 435 541 9.7E-35 T 13-10-2018 IPR003594 Histidine kinase/HSP90-like ATPase TOPB45_0894 2ed092a7a6571576b75818fb2e49646a 543 Pfam PF00512 His Kinase A (phospho-acceptor) domain 330 389 1.5E-10 T 13-10-2018 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TOPB45_1411 1b0c2b81940d6b040e05f59224d54e8c 240 Pfam PF11306 Protein of unknown function (DUF3108) 30 236 4.4E-14 T 13-10-2018 IPR021457 Protein of unknown function DUF3108 TOPB45_0877 8581bd0e9ae68bc277dd1c8247083d83 89 Pfam PF09527 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter 20 70 2.9E-11 T 13-10-2018 IPR032820 Putative F0F1-ATPase subunit, Ca2+/Mg2+ transporter TOPB45_0771 95005825aa4cf3c282dacd7fe7fbeb07 61 Pfam PF00327 Ribosomal protein L30p/L7e 4 54 3.8E-19 T 13-10-2018 IPR016082 Ribosomal protein L30, ferredoxin-like fold domain TOPB45_0771 95005825aa4cf3c282dacd7fe7fbeb07 61 Gene3D G3DSA:3.30.1390.20 1 59 2.6E-25 T 13-10-2018 IPR036919 Ribosomal protein L30, ferredoxin-like fold domain superfamily TOPB45_0771 95005825aa4cf3c282dacd7fe7fbeb07 61 Hamap MF_01371_B 50S ribosomal protein L30 [rpmD]. 1 58 21.07 T 13-10-2018 IPR005996 Ribosomal protein L30, bacterial-type GO:0003735|GO:0006412|GO:0015934 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0771 95005825aa4cf3c282dacd7fe7fbeb07 61 PIRSF PIRSF002211 1 60 1.8E-28 T 13-10-2018 IPR005996 Ribosomal protein L30, bacterial-type GO:0003735|GO:0006412|GO:0015934 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0771 95005825aa4cf3c282dacd7fe7fbeb07 61 SUPERFAMILY SSF55129 1 60 7.59E-21 T 13-10-2018 IPR036919 Ribosomal protein L30, ferredoxin-like fold domain superfamily TOPB45_0771 95005825aa4cf3c282dacd7fe7fbeb07 61 TIGRFAM TIGR01308 rpmD_bact: ribosomal protein uL30 4 58 4.0E-24 T 13-10-2018 IPR005996 Ribosomal protein L30, bacterial-type GO:0003735|GO:0006412|GO:0015934 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0771 95005825aa4cf3c282dacd7fe7fbeb07 61 ProSitePatterns PS00634 Ribosomal protein L30 signature. 22 54 - T 13-10-2018 IPR018038 Ribosomal protein L30, conserved site TOPB45_0191 75f227779da22818413e792472759fb1 127 SUPERFAMILY SSF55811 5 125 1.49E-30 T 13-10-2018 IPR015797 NUDIX hydrolase-like domain superfamily GO:0016787 TOPB45_0191 75f227779da22818413e792472759fb1 127 Pfam PF00293 NUDIX domain 10 121 3.6E-23 T 13-10-2018 IPR000086 NUDIX hydrolase domain GO:0016787 TOPB45_0191 75f227779da22818413e792472759fb1 127 PRINTS PR00502 NUDIX hydrolase family signature 31 45 8.2E-9 T 13-10-2018 IPR020476 NUDIX hydrolase Reactome: R-HSA-2393930 TOPB45_0191 75f227779da22818413e792472759fb1 127 PRINTS PR00502 NUDIX hydrolase family signature 45 60 8.2E-9 T 13-10-2018 IPR020476 NUDIX hydrolase Reactome: R-HSA-2393930 TOPB45_0191 75f227779da22818413e792472759fb1 127 Gene3D G3DSA:3.90.79.10 1 126 6.9E-36 T 13-10-2018 TOPB45_0191 75f227779da22818413e792472759fb1 127 ProSitePatterns PS00893 Nudix box signature. 36 57 - T 13-10-2018 IPR020084 NUDIX hydrolase, conserved site GO:0016787 TOPB45_1283 94875051758bb48bf836d6ee2e45adb9 281 Hamap MF_00254 Glycine--tRNA ligase alpha subunit [glyQ]. 1 281 59.57 T 13-10-2018 IPR002310 Glycine-tRNA ligase, alpha subunit GO:0000166|GO:0004820|GO:0005524|GO:0005737|GO:0006426 KEGG: 00970+6.1.1.14 TOPB45_1283 94875051758bb48bf836d6ee2e45adb9 281 PRINTS PR01044 Glycyl-tRNA synthetase alpha subunit signature 55 70 6.0E-65 T 13-10-2018 IPR002310 Glycine-tRNA ligase, alpha subunit GO:0000166|GO:0004820|GO:0005524|GO:0005737|GO:0006426 KEGG: 00970+6.1.1.14 TOPB45_1283 94875051758bb48bf836d6ee2e45adb9 281 PRINTS PR01044 Glycyl-tRNA synthetase alpha subunit signature 241 257 6.0E-65 T 13-10-2018 IPR002310 Glycine-tRNA ligase, alpha subunit GO:0000166|GO:0004820|GO:0005524|GO:0005737|GO:0006426 KEGG: 00970+6.1.1.14 TOPB45_1283 94875051758bb48bf836d6ee2e45adb9 281 PRINTS PR01044 Glycyl-tRNA synthetase alpha subunit signature 133 153 6.0E-65 T 13-10-2018 IPR002310 Glycine-tRNA ligase, alpha subunit GO:0000166|GO:0004820|GO:0005524|GO:0005737|GO:0006426 KEGG: 00970+6.1.1.14 TOPB45_1283 94875051758bb48bf836d6ee2e45adb9 281 PRINTS PR01044 Glycyl-tRNA synthetase alpha subunit signature 156 171 6.0E-65 T 13-10-2018 IPR002310 Glycine-tRNA ligase, alpha subunit GO:0000166|GO:0004820|GO:0005524|GO:0005737|GO:0006426 KEGG: 00970+6.1.1.14 TOPB45_1283 94875051758bb48bf836d6ee2e45adb9 281 PRINTS PR01044 Glycyl-tRNA synthetase alpha subunit signature 76 96 6.0E-65 T 13-10-2018 IPR002310 Glycine-tRNA ligase, alpha subunit GO:0000166|GO:0004820|GO:0005524|GO:0005737|GO:0006426 KEGG: 00970+6.1.1.14 TOPB45_1283 94875051758bb48bf836d6ee2e45adb9 281 PRINTS PR01044 Glycyl-tRNA synthetase alpha subunit signature 107 131 6.0E-65 T 13-10-2018 IPR002310 Glycine-tRNA ligase, alpha subunit GO:0000166|GO:0004820|GO:0005524|GO:0005737|GO:0006426 KEGG: 00970+6.1.1.14 TOPB45_1283 94875051758bb48bf836d6ee2e45adb9 281 Pfam PF02091 Glycyl-tRNA synthetase alpha subunit 3 279 1.1E-151 T 13-10-2018 IPR002310 Glycine-tRNA ligase, alpha subunit GO:0000166|GO:0004820|GO:0005524|GO:0005737|GO:0006426 KEGG: 00970+6.1.1.14 TOPB45_1283 94875051758bb48bf836d6ee2e45adb9 281 TIGRFAM TIGR00388 glyQ: glycine--tRNA ligase, alpha subunit 2 280 4.6E-150 T 13-10-2018 IPR002310 Glycine-tRNA ligase, alpha subunit GO:0000166|GO:0004820|GO:0005524|GO:0005737|GO:0006426 KEGG: 00970+6.1.1.14 TOPB45_1283 94875051758bb48bf836d6ee2e45adb9 281 SUPERFAMILY SSF55681 1 280 1.09E-132 T 13-10-2018 TOPB45_1283 94875051758bb48bf836d6ee2e45adb9 281 Gene3D G3DSA:3.30.930.10 1 204 3.7E-112 T 13-10-2018 TOPB45_1283 94875051758bb48bf836d6ee2e45adb9 281 Gene3D G3DSA:1.20.58.180 205 281 3.0E-29 T 13-10-2018 TOPB45_0170 40d22ed7d46bc5f4029adbc121341ee7 79 TIGRFAM TIGR00964 secE_bact: preprotein translocase, SecE subunit 24 78 1.5E-14 T 13-10-2018 IPR005807 SecE subunit of protein translocation complex, bacterial-like GO:0009306|GO:0015450|GO:0016021 TOPB45_0170 40d22ed7d46bc5f4029adbc121341ee7 79 Pfam PF00584 SecE/Sec61-gamma subunits of protein translocation complex 24 77 2.1E-15 T 13-10-2018 IPR001901 Protein translocase complex, SecE/Sec61-gamma subunit GO:0006605|GO:0006886|GO:0016020 Reactome: R-HSA-1236974|Reactome: R-HSA-1799339|Reactome: R-HSA-381038 TOPB45_0170 40d22ed7d46bc5f4029adbc121341ee7 79 Hamap MF_00422 Protein translocase subunit SecE [secE]. 21 76 11.303 T 13-10-2018 IPR001901 Protein translocase complex, SecE/Sec61-gamma subunit GO:0006605|GO:0006886|GO:0016020 Reactome: R-HSA-1236974|Reactome: R-HSA-1799339|Reactome: R-HSA-381038 TOPB45_0170 40d22ed7d46bc5f4029adbc121341ee7 79 Gene3D G3DSA:1.20.5.1030 19 77 1.6E-17 T 13-10-2018 IPR038379 SecE superfamily TOPB45_0854 6d35a056a0bb86e28ab122d8e9d872de 125 SMART SM01078 3 115 2.3E-16 T 13-10-2018 IPR014925 Uncharacterised domain CGGC-dom TOPB45_0854 6d35a056a0bb86e28ab122d8e9d872de 125 Pfam PF08821 CGGC domain 3 115 1.4E-26 T 13-10-2018 IPR014925 Uncharacterised domain CGGC-dom TOPB45_1558 f0971e3ea26fd6aefe5a141c98bc3367 252 Pfam PF12706 Beta-lactamase superfamily domain 31 221 2.2E-19 T 13-10-2018 IPR001279 Metallo-beta-lactamase TOPB45_1558 f0971e3ea26fd6aefe5a141c98bc3367 252 SMART SM00849 18 220 4.6E-6 T 13-10-2018 IPR001279 Metallo-beta-lactamase TOPB45_1558 f0971e3ea26fd6aefe5a141c98bc3367 252 Gene3D G3DSA:3.60.15.10 1 251 3.0E-64 T 13-10-2018 IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like TOPB45_1558 f0971e3ea26fd6aefe5a141c98bc3367 252 SUPERFAMILY SSF56281 1 252 6.77E-54 T 13-10-2018 IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like TOPB45_0044 49e4564d0e484d33d77499387f45f1f1 396 Pfam PF01837 Homocysteine biosynthesis enzyme, sulfur-incorporation 23 380 2.2E-148 T 13-10-2018 IPR002708 Homocysteine biosynthesis enzyme, sulfur-incorporation TOPB45_0044 49e4564d0e484d33d77499387f45f1f1 396 ProDom PD011569 METAL-BINDING IRON IRON-SULFUR 4FE-4S FERREDOXIN OXIDOREDUCTASE DOMAIN ELECTRON METHANOGENESIS A 26 302 3.0E-116 T 13-10-2018 IPR002708 Homocysteine biosynthesis enzyme, sulfur-incorporation TOPB45_0745 4f4873476d0a9a102425e2b7d81c5ec1 126 SUPERFAMILY SSF48371 36 104 3.45E-5 T 13-10-2018 IPR016024 Armadillo-type fold TOPB45_0745 4f4873476d0a9a102425e2b7d81c5ec1 126 Gene3D G3DSA:1.25.10.10 24 122 1.5E-6 T 13-10-2018 IPR011989 Armadillo-like helical TOPB45_0082 4360392f80f370e275331242267addf1 177 Pfam PF02620 Uncharacterized ACR, COG1399 54 171 8.3E-26 T 13-10-2018 IPR003772 Large ribosomal RNA subunit accumulation protein YceD TOPB45_0869 df3e820524ff3c5d0e599f0566183a6c 307 Pfam PF07726 ATPase family associated with various cellular activities (AAA) 37 167 9.6E-63 T 13-10-2018 IPR011703 ATPase, AAA-3 GO:0005524|GO:0016887 TOPB45_0869 df3e820524ff3c5d0e599f0566183a6c 307 SUPERFAMILY SSF52540 6 281 2.6E-46 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0869 df3e820524ff3c5d0e599f0566183a6c 307 PIRSF PIRSF002849 1 307 2.0E-125 T 13-10-2018 TOPB45_0869 df3e820524ff3c5d0e599f0566183a6c 307 Gene3D G3DSA:1.10.8.300 198 303 6.0E-31 T 13-10-2018 TOPB45_0869 df3e820524ff3c5d0e599f0566183a6c 307 Gene3D G3DSA:3.40.50.300 18 184 7.2E-45 T 13-10-2018 TOPB45_0743 2462f418b765211d08d67dbf8a20e26d 412 ProSitePatterns PS00096 Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. 218 234 - T 13-10-2018 IPR019798 Serine hydroxymethyltransferase, pyridoxal phosphate binding site GO:0030170 KEGG: 00260+2.1.2.1|KEGG: 00460+2.1.2.1|KEGG: 00630+2.1.2.1|KEGG: 00670+2.1.2.1|KEGG: 00680+2.1.2.1|MetaCyc: PWY-1622|MetaCyc: PWY-181|MetaCyc: PWY-2161|MetaCyc: PWY-2201|MetaCyc: PWY-3661|MetaCyc: PWY-3661-1|MetaCyc: PWY-3841|MetaCyc: PWY-5497|Reactome: R-HSA-196757 TOPB45_0743 2462f418b765211d08d67dbf8a20e26d 412 PIRSF PIRSF000412 1 412 1.9E-168 T 13-10-2018 IPR001085 Serine hydroxymethyltransferase GO:0004372|GO:0019264|GO:0030170|GO:0035999 KEGG: 00260+2.1.2.1|KEGG: 00460+2.1.2.1|KEGG: 00630+2.1.2.1|KEGG: 00670+2.1.2.1|KEGG: 00680+2.1.2.1|MetaCyc: PWY-1622|MetaCyc: PWY-181|MetaCyc: PWY-2161|MetaCyc: PWY-2201|MetaCyc: PWY-3661|MetaCyc: PWY-3661-1|MetaCyc: PWY-3841|MetaCyc: PWY-5497|Reactome: R-HSA-196757 TOPB45_0743 2462f418b765211d08d67dbf8a20e26d 412 Gene3D G3DSA:3.40.640.10 33 283 2.7E-191 T 13-10-2018 IPR015421 Pyridoxal phosphate-dependent transferase, major domain GO:0003824 TOPB45_0743 2462f418b765211d08d67dbf8a20e26d 412 Gene3D G3DSA:3.90.1150.10 6 389 2.7E-191 T 13-10-2018 IPR015422 Pyridoxal phosphate-dependent transferase domain 1 GO:0003824 TOPB45_0743 2462f418b765211d08d67dbf8a20e26d 412 Pfam PF00464 Serine hydroxymethyltransferase 4 380 5.1E-173 T 13-10-2018 IPR039429 Serine hydroxymethyltransferase-like domain KEGG: 00260+2.1.2.1|KEGG: 00460+2.1.2.1|KEGG: 00630+2.1.2.1|KEGG: 00670+2.1.2.1|KEGG: 00680+2.1.2.1|MetaCyc: PWY-1622|MetaCyc: PWY-181|MetaCyc: PWY-2161|MetaCyc: PWY-2201|MetaCyc: PWY-3661|MetaCyc: PWY-3661-1|MetaCyc: PWY-3841|MetaCyc: PWY-5497|Reactome: R-HSA-196757 TOPB45_0743 2462f418b765211d08d67dbf8a20e26d 412 SUPERFAMILY SSF53383 2 411 1.29E-180 T 13-10-2018 IPR015424 Pyridoxal phosphate-dependent transferase TOPB45_0743 2462f418b765211d08d67dbf8a20e26d 412 Hamap MF_00051 Serine hydroxymethyltransferase [glyA]. 3 411 53.889 T 13-10-2018 IPR001085 Serine hydroxymethyltransferase GO:0004372|GO:0019264|GO:0030170|GO:0035999 KEGG: 00260+2.1.2.1|KEGG: 00460+2.1.2.1|KEGG: 00630+2.1.2.1|KEGG: 00670+2.1.2.1|KEGG: 00680+2.1.2.1|MetaCyc: PWY-1622|MetaCyc: PWY-181|MetaCyc: PWY-2161|MetaCyc: PWY-2201|MetaCyc: PWY-3661|MetaCyc: PWY-3661-1|MetaCyc: PWY-3841|MetaCyc: PWY-5497|Reactome: R-HSA-196757 TOPB45_0376 bce4fcb4f45caedacaa569ba3a6dedbb 438 Hamap MF_00127 Histidine--tRNA ligase [hisS]. 1 436 30.733 T 13-10-2018 IPR015807 Histidine-tRNA ligase GO:0004821|GO:0005524|GO:0006427 KEGG: 00970+6.1.1.21 TOPB45_0376 bce4fcb4f45caedacaa569ba3a6dedbb 438 TIGRFAM TIGR00442 hisS: histidine--tRNA ligase 4 419 1.6E-134 T 13-10-2018 IPR015807 Histidine-tRNA ligase GO:0004821|GO:0005524|GO:0006427 KEGG: 00970+6.1.1.21 TOPB45_0376 bce4fcb4f45caedacaa569ba3a6dedbb 438 Gene3D G3DSA:3.40.50.800 338 423 2.6E-22 T 13-10-2018 IPR036621 Anticodon-binding domain superfamily TOPB45_0376 bce4fcb4f45caedacaa569ba3a6dedbb 438 PIRSF PIRSF001549 1 431 4.1E-108 T 13-10-2018 IPR004516 Histidine-tRNA ligase/ATP phosphoribosyltransferase regulatory subunit GO:0005737 TOPB45_0376 bce4fcb4f45caedacaa569ba3a6dedbb 438 Gene3D G3DSA:3.30.930.10 1 322 5.1E-104 T 13-10-2018 TOPB45_0376 bce4fcb4f45caedacaa569ba3a6dedbb 438 SUPERFAMILY SSF55681 2 320 1.57E-90 T 13-10-2018 TOPB45_0376 bce4fcb4f45caedacaa569ba3a6dedbb 438 SUPERFAMILY SSF52954 339 424 1.43E-17 T 13-10-2018 TOPB45_0376 bce4fcb4f45caedacaa569ba3a6dedbb 438 Pfam PF13393 Histidyl-tRNA synthetase 8 313 4.8E-37 T 13-10-2018 TOPB45_0376 bce4fcb4f45caedacaa569ba3a6dedbb 438 Pfam PF03129 Anticodon binding domain 341 423 6.6E-11 T 13-10-2018 IPR004154 Anticodon-binding TOPB45_0874 68dd171f2fbc96a17f6abe2f1845c7e1 273 Gene3D G3DSA:1.10.8.590 176 253 8.6E-10 T 13-10-2018 TOPB45_0874 68dd171f2fbc96a17f6abe2f1845c7e1 273 Pfam PF00588 SpoU rRNA Methylase family 17 166 4.8E-31 T 13-10-2018 IPR001537 tRNA/rRNA methyltransferase, SpoU type GO:0003723|GO:0006396|GO:0008173 TOPB45_0874 68dd171f2fbc96a17f6abe2f1845c7e1 273 Gene3D G3DSA:3.40.1280.10 13 175 5.4E-50 T 13-10-2018 IPR029026 tRNA (guanine-N1-)-methyltransferase, N-terminal TOPB45_0874 68dd171f2fbc96a17f6abe2f1845c7e1 273 SUPERFAMILY SSF75217 7 192 2.03E-35 T 13-10-2018 IPR029028 Alpha/beta knot methyltransferases TOPB45_0874 68dd171f2fbc96a17f6abe2f1845c7e1 273 PIRSF PIRSF004808 11 250 1.1E-62 T 13-10-2018 IPR004384 RNA methyltransferase TrmJ/LasT GO:0006396|GO:0008173 TOPB45_0874 68dd171f2fbc96a17f6abe2f1845c7e1 273 TIGRFAM TIGR00050 rRNA_methyl_1: RNA methyltransferase, TrmH family, group 1 14 241 9.0E-56 T 13-10-2018 IPR004384 RNA methyltransferase TrmJ/LasT GO:0006396|GO:0008173 TOPB45_1612 22f0ce567cc57190a87fdefcb7fc8edf 531 Gene3D G3DSA:3.90.700.10 240 351 4.0E-157 T 13-10-2018 IPR027477 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily Reactome: R-HSA-611105|Reactome: R-HSA-71403 TOPB45_1612 22f0ce567cc57190a87fdefcb7fc8edf 531 SUPERFAMILY SSF46977 426 520 4.19E-22 T 13-10-2018 IPR037099 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-71403 TOPB45_1612 22f0ce567cc57190a87fdefcb7fc8edf 531 PIRSF PIRSF000171 1 530 1.8E-40 T 13-10-2018 TOPB45_1612 22f0ce567cc57190a87fdefcb7fc8edf 531 Gene3D G3DSA:1.20.58.100 421 531 1.9E-27 T 13-10-2018 TOPB45_1612 22f0ce567cc57190a87fdefcb7fc8edf 531 TIGRFAM TIGR00551 nadB: L-aspartate oxidase 5 515 4.5E-176 T 13-10-2018 IPR005288 L-aspartate oxidase GO:0005737|GO:0008734|GO:0009435|GO:0055114 KEGG: 00250+1.4.3.16|KEGG: 00760+1.4.3.16|MetaCyc: PWY-5316|MetaCyc: PWY-7342 TOPB45_1612 22f0ce567cc57190a87fdefcb7fc8edf 531 Pfam PF02910 Fumarate reductase flavoprotein C-term 438 527 2.0E-10 T 13-10-2018 IPR015939 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-71403 TOPB45_1612 22f0ce567cc57190a87fdefcb7fc8edf 531 Gene3D G3DSA:3.50.50.60 7 395 4.0E-157 T 13-10-2018 IPR036188 FAD/NAD(P)-binding domain superfamily TOPB45_1612 22f0ce567cc57190a87fdefcb7fc8edf 531 SUPERFAMILY SSF51905 2 409 2.59E-65 T 13-10-2018 IPR036188 FAD/NAD(P)-binding domain superfamily TOPB45_1612 22f0ce567cc57190a87fdefcb7fc8edf 531 Pfam PF00890 FAD binding domain 7 385 3.9E-98 T 13-10-2018 IPR003953 FAD-dependent oxidoreductase 2, FAD binding domain Reactome: R-HSA-611105|Reactome: R-HSA-71403 TOPB45_1612 22f0ce567cc57190a87fdefcb7fc8edf 531 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 8 27 5.4E-7 T 13-10-2018 TOPB45_1612 22f0ce567cc57190a87fdefcb7fc8edf 531 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 348 370 5.4E-7 T 13-10-2018 TOPB45_1612 22f0ce567cc57190a87fdefcb7fc8edf 531 SUPERFAMILY SSF56425 230 345 1.94E-45 T 13-10-2018 IPR027477 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily Reactome: R-HSA-611105|Reactome: R-HSA-71403 TOPB45_0232 d01a7f792855457b8a64d50d5ac52b61 185 Pfam PF03602 Conserved hypothetical protein 95 1 183 7.7E-47 T 13-10-2018 TOPB45_0232 d01a7f792855457b8a64d50d5ac52b61 185 Gene3D G3DSA:3.40.50.150 1 185 4.2E-51 T 13-10-2018 TOPB45_0232 d01a7f792855457b8a64d50d5ac52b61 185 SUPERFAMILY SSF53335 1 183 7.81E-39 T 13-10-2018 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TOPB45_0232 d01a7f792855457b8a64d50d5ac52b61 185 PIRSF PIRSF004553 1 185 2.7E-46 T 13-10-2018 IPR004398 RNA methyltransferase, RsmD GO:0008168|GO:0031167 TOPB45_0232 d01a7f792855457b8a64d50d5ac52b61 185 TIGRFAM TIGR00095 TIGR00095: 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD 2 183 2.8E-41 T 13-10-2018 IPR004398 RNA methyltransferase, RsmD GO:0008168|GO:0031167 TOPB45_1317 83f61894e2b7d9ed26901f915544da35 199 SMART SM00507 95 149 3.5E-15 T 13-10-2018 IPR003615 HNH nuclease TOPB45_1317 83f61894e2b7d9ed26901f915544da35 199 Pfam PF14279 HNH endonuclease 108 160 5.8E-18 T 13-10-2018 IPR029471 HNH endonuclease 5 TOPB45_1317 83f61894e2b7d9ed26901f915544da35 199 Gene3D G3DSA:3.30.40.60 91 184 1.7E-23 T 13-10-2018 TOPB45_0109 251bc02a06ff132c4501d70ad73e930e 811 PIRSF PIRSF000854 2 809 0.0 T 13-10-2018 IPR006319 Phosphoenolpyruvate synthase GO:0006090|GO:0008986 KEGG: 00620+2.7.9.2|KEGG: 00680+2.7.9.2|KEGG: 00720+2.7.9.2|MetaCyc: PWY-5484|MetaCyc: PWY-6142 TOPB45_0109 251bc02a06ff132c4501d70ad73e930e 811 Gene3D G3DSA:3.20.20.60 484 806 9.7E-105 T 13-10-2018 TOPB45_0109 251bc02a06ff132c4501d70ad73e930e 811 SUPERFAMILY SSF52009 352 462 4.06E-32 T 13-10-2018 IPR036637 Phosphohistidine domain superfamily GO:0016310|GO:0016772 TOPB45_0109 251bc02a06ff132c4501d70ad73e930e 811 Gene3D G3DSA:3.30.1490.20 4 196 3.0E-76 T 13-10-2018 IPR013815 ATP-grasp fold, subdomain 1 GO:0005524 TOPB45_0109 251bc02a06ff132c4501d70ad73e930e 811 Gene3D G3DSA:3.30.470.20 197 362 1.0E-56 T 13-10-2018 TOPB45_0109 251bc02a06ff132c4501d70ad73e930e 811 SUPERFAMILY SSF51621 470 805 4.97E-99 T 13-10-2018 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily GO:0003824 TOPB45_0109 251bc02a06ff132c4501d70ad73e930e 811 ProSitePatterns PS00742 PEP-utilizing enzymes signature 2. 709 727 - T 13-10-2018 IPR023151 PEP-utilising enzyme, conserved site GO:0016772 TOPB45_0109 251bc02a06ff132c4501d70ad73e930e 811 ProSitePatterns PS00370 PEP-utilizing enzymes phosphorylation site signature. 420 431 - T 13-10-2018 IPR018274 PEP-utilising enzyme, active site GO:0016310|GO:0016772 TOPB45_0109 251bc02a06ff132c4501d70ad73e930e 811 Gene3D G3DSA:3.50.30.10 363 471 7.3E-42 T 13-10-2018 TOPB45_0109 251bc02a06ff132c4501d70ad73e930e 811 Pfam PF02896 PEP-utilising enzyme, TIM barrel domain 484 803 7.0E-68 T 13-10-2018 IPR000121 PEP-utilising enzyme, C-terminal GO:0016310|GO:0016772 TOPB45_0109 251bc02a06ff132c4501d70ad73e930e 811 PRINTS PR01736 Phosphoenolpyruvate-protein phosphotransferase signature 709 724 9.8E-7 T 13-10-2018 TOPB45_0109 251bc02a06ff132c4501d70ad73e930e 811 PRINTS PR01736 Phosphoenolpyruvate-protein phosphotransferase signature 726 741 9.8E-7 T 13-10-2018 TOPB45_0109 251bc02a06ff132c4501d70ad73e930e 811 PRINTS PR01736 Phosphoenolpyruvate-protein phosphotransferase signature 762 774 9.8E-7 T 13-10-2018 TOPB45_0109 251bc02a06ff132c4501d70ad73e930e 811 SUPERFAMILY SSF56059 4 391 1.29E-112 T 13-10-2018 TOPB45_0109 251bc02a06ff132c4501d70ad73e930e 811 Pfam PF01326 Pyruvate phosphate dikinase, PEP/pyruvate binding domain 20 348 2.8E-122 T 13-10-2018 IPR002192 Pyruvate phosphate dikinase, PEP/pyruvate-binding GO:0005524|GO:0016301|GO:0016310 TOPB45_0109 251bc02a06ff132c4501d70ad73e930e 811 Pfam PF00391 PEP-utilising enzyme, mobile domain 390 461 3.0E-26 T 13-10-2018 IPR008279 PEP-utilising enzyme, mobile domain GO:0016310|GO:0016772 TOPB45_0109 251bc02a06ff132c4501d70ad73e930e 811 TIGRFAM TIGR01418 PEP_synth: phosphoenolpyruvate synthase 8 805 0.0 T 13-10-2018 IPR006319 Phosphoenolpyruvate synthase GO:0006090|GO:0008986 KEGG: 00620+2.7.9.2|KEGG: 00680+2.7.9.2|KEGG: 00720+2.7.9.2|MetaCyc: PWY-5484|MetaCyc: PWY-6142 TOPB45_1310 900bfe147d5307142a0484a4e5e15a63 220 Gene3D G3DSA:3.40.50.300 2 220 8.0E-63 T 13-10-2018 TOPB45_1310 900bfe147d5307142a0484a4e5e15a63 220 Pfam PF00005 ABC transporter 21 167 1.4E-27 T 13-10-2018 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TOPB45_1310 900bfe147d5307142a0484a4e5e15a63 220 SMART SM00382 30 213 6.3E-10 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_1310 900bfe147d5307142a0484a4e5e15a63 220 SUPERFAMILY SSF52540 5 217 2.72E-55 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0994 647bd085c8cc3b372938b182de0b6a93 202 Pfam PF13662 Toprim domain 83 172 3.7E-16 T 13-10-2018 IPR006171 TOPRIM domain TOPB45_0994 647bd085c8cc3b372938b182de0b6a93 202 Gene3D G3DSA:1.10.8.420 4 52 3.9E-10 T 13-10-2018 TOPB45_0994 647bd085c8cc3b372938b182de0b6a93 202 ProSitePatterns PS01300 RecR protein signature. 58 79 - T 13-10-2018 IPR015967 Recombination protein RecR, conserved site GO:0006281|GO:0006310 TOPB45_0994 647bd085c8cc3b372938b182de0b6a93 202 Hamap MF_00017 Recombination protein RecR [recR]. 1 199 70.937 T 13-10-2018 IPR000093 DNA recombination protein RecR GO:0003677|GO:0006281|GO:0006310 TOPB45_0994 647bd085c8cc3b372938b182de0b6a93 202 TIGRFAM TIGR00615 recR: recombination protein RecR 5 196 1.5E-59 T 13-10-2018 IPR000093 DNA recombination protein RecR GO:0003677|GO:0006281|GO:0006310 TOPB45_0994 647bd085c8cc3b372938b182de0b6a93 202 SUPERFAMILY SSF111304 5 199 2.09E-62 T 13-10-2018 IPR023627 Recombination protein RecR TOPB45_0994 647bd085c8cc3b372938b182de0b6a93 202 Pfam PF02132 RecR protein 44 79 1.7E-10 T 13-10-2018 IPR023628 Recombination protein RecR, C4-type zinc finger TOPB45_0994 647bd085c8cc3b372938b182de0b6a93 202 Gene3D G3DSA:3.40.1360.10 78 198 2.2E-36 T 13-10-2018 TOPB45_0841 b6a3a1433c36740f13d2833a35e963ac 248 Pfam PF02673 Bacitracin resistance protein BacA 6 241 6.5E-72 T 13-10-2018 IPR003824 Undecaprenyl-diphosphatase UppP GO:0016020|GO:0016311|GO:0050380 KEGG: 00550+3.6.1.27|MetaCyc: PWY-5785 TOPB45_0841 b6a3a1433c36740f13d2833a35e963ac 248 Hamap MF_01006 Undecaprenyl-diphosphatase [uppP]. 1 246 17.237 T 13-10-2018 IPR003824 Undecaprenyl-diphosphatase UppP GO:0016020|GO:0016311|GO:0050380 KEGG: 00550+3.6.1.27|MetaCyc: PWY-5785 TOPB45_1526 c93c93f101d0de1a073286341309bd32 149 Gene3D G3DSA:3.40.630.30 2 140 2.8E-34 T 13-10-2018 TOPB45_1526 c93c93f101d0de1a073286341309bd32 149 Pfam PF00583 Acetyltransferase (GNAT) family 40 115 2.5E-13 T 13-10-2018 IPR000182 GNAT domain TOPB45_1526 c93c93f101d0de1a073286341309bd32 149 SUPERFAMILY SSF55729 1 127 1.13E-23 T 13-10-2018 IPR016181 Acyl-CoA N-acyltransferase TOPB45_0148 963d024e34425fd135d06b91770b023e 435 SUPERFAMILY SSF116734 8 222 1.29E-48 T 13-10-2018 TOPB45_0148 963d024e34425fd135d06b91770b023e 435 SUPERFAMILY SSF116734 228 433 2.94E-39 T 13-10-2018 TOPB45_0148 963d024e34425fd135d06b91770b023e 435 Pfam PF01420 Type I restriction modification DNA specificity domain 18 203 4.0E-22 T 13-10-2018 IPR000055 Restriction endonuclease, type I, HsdS GO:0003677|GO:0006304 TOPB45_0148 963d024e34425fd135d06b91770b023e 435 Pfam PF01420 Type I restriction modification DNA specificity domain 236 411 7.8E-21 T 13-10-2018 IPR000055 Restriction endonuclease, type I, HsdS GO:0003677|GO:0006304 TOPB45_0148 963d024e34425fd135d06b91770b023e 435 Gene3D G3DSA:3.90.220.20 240 384 2.9E-78 T 13-10-2018 TOPB45_0148 963d024e34425fd135d06b91770b023e 435 Gene3D G3DSA:1.10.287.1120 172 427 2.9E-78 T 13-10-2018 TOPB45_0148 963d024e34425fd135d06b91770b023e 435 Gene3D G3DSA:3.90.220.20 15 431 2.9E-78 T 13-10-2018 TOPB45_1479 23b8bf15721a181fbcb2a38eb8c0f1bc 155 SUPERFAMILY SSF75420 4 84 4.45E-23 T 13-10-2018 IPR035956 RimP, N-terminal domain superfamily TOPB45_1479 23b8bf15721a181fbcb2a38eb8c0f1bc 155 Pfam PF02576 RimP N-terminal domain 17 84 1.0E-25 T 13-10-2018 IPR028989 Ribosome maturation factor RimP, N-terminal TOPB45_1479 23b8bf15721a181fbcb2a38eb8c0f1bc 155 Gene3D G3DSA:3.30.300.70 2 81 4.5E-29 T 13-10-2018 IPR035956 RimP, N-terminal domain superfamily TOPB45_1479 23b8bf15721a181fbcb2a38eb8c0f1bc 155 Pfam PF17384 RimP C-terminal SH3 domain 87 151 1.8E-18 T 13-10-2018 IPR028998 Ribosome maturation factor RimP, C-terminal TOPB45_1479 23b8bf15721a181fbcb2a38eb8c0f1bc 155 SUPERFAMILY SSF74942 85 152 2.22E-17 T 13-10-2018 IPR036847 Ribosome maturation factor RimP, C-terminal domain superfamily TOPB45_1479 23b8bf15721a181fbcb2a38eb8c0f1bc 155 Hamap MF_01077 Ribosome maturation factor RimP [rimP]. 7 152 23.878 T 13-10-2018 IPR003728 Ribosome maturation factor RimP GO:0042274 TOPB45_0273 faa41ea2448f729f6d62fc0cf91db2de 517 Pfam PF00990 Diguanylate cyclase, GGDEF domain 359 511 1.5E-44 T 13-10-2018 IPR000160 GGDEF domain TOPB45_0273 faa41ea2448f729f6d62fc0cf91db2de 517 SMART SM00267 347 515 4.8E-57 T 13-10-2018 IPR000160 GGDEF domain TOPB45_0273 faa41ea2448f729f6d62fc0cf91db2de 517 Gene3D G3DSA:3.30.70.270 345 516 1.5E-55 T 13-10-2018 TOPB45_0273 faa41ea2448f729f6d62fc0cf91db2de 517 TIGRFAM TIGR00254 GGDEF: diguanylate cyclase (GGDEF) domain 358 514 2.5E-52 T 13-10-2018 IPR000160 GGDEF domain TOPB45_0273 faa41ea2448f729f6d62fc0cf91db2de 517 Pfam PF14827 Double sensory domain of two-component sensor kinase 92 311 5.3E-8 T 13-10-2018 IPR029150 Double Cache domain 3 TOPB45_0273 faa41ea2448f729f6d62fc0cf91db2de 517 SUPERFAMILY SSF55073 363 514 9.42E-47 T 13-10-2018 IPR029787 Nucleotide cyclase TOPB45_0844 27659c4134a566206f1dc23fc1a5747c 422 Pfam PF00275 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) 8 408 2.3E-97 T 13-10-2018 IPR001986 Enolpyruvate transferase domain GO:0016765 TOPB45_0844 27659c4134a566206f1dc23fc1a5747c 422 SUPERFAMILY SSF55205 4 419 8.76E-130 T 13-10-2018 IPR013792 RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta GO:0003824 TOPB45_0844 27659c4134a566206f1dc23fc1a5747c 422 Gene3D G3DSA:3.65.10.10 7 415 6.7E-161 T 13-10-2018 IPR036968 Enolpyruvate transferase domain superfamily GO:0016765 TOPB45_0844 27659c4134a566206f1dc23fc1a5747c 422 Gene3D G3DSA:3.65.10.10 22 229 6.7E-161 T 13-10-2018 IPR036968 Enolpyruvate transferase domain superfamily GO:0016765 TOPB45_0844 27659c4134a566206f1dc23fc1a5747c 422 Hamap MF_00111 UDP-N-acetylglucosamine 1-carboxyvinyltransferase [murA]. 2 418 39.04 T 13-10-2018 IPR005750 UDP-N-acetylglucosamine 1-carboxyvinyltransferase GO:0008760|GO:0019277 KEGG: 00520+2.5.1.7|KEGG: 00550+2.5.1.7|MetaCyc: PWY-6386|MetaCyc: PWY-6387|MetaCyc: PWY-7953 TOPB45_0844 27659c4134a566206f1dc23fc1a5747c 422 TIGRFAM TIGR01072 murA: UDP-N-acetylglucosamine 1-carboxyvinyltransferase 4 416 9.0E-162 T 13-10-2018 IPR005750 UDP-N-acetylglucosamine 1-carboxyvinyltransferase GO:0008760|GO:0019277 KEGG: 00520+2.5.1.7|KEGG: 00550+2.5.1.7|MetaCyc: PWY-6386|MetaCyc: PWY-6387|MetaCyc: PWY-7953 TOPB45_0509 02038704e496a39fe426b6318ce5821c 497 SUPERFAMILY SSF52402 118 467 1.91E-15 T 13-10-2018 TOPB45_0509 02038704e496a39fe426b6318ce5821c 497 Pfam PF00733 Asparagine synthase 149 413 9.3E-7 T 13-10-2018 IPR001962 Asparagine synthase GO:0004066|GO:0006529 TOPB45_0967 efbafa3c23442dcf7c0e4e968a35e879 426 SUPERFAMILY SSF102114 182 351 2.62E-40 T 13-10-2018 TOPB45_0967 efbafa3c23442dcf7c0e4e968a35e879 426 Gene3D G3DSA:3.80.30.20 180 362 1.7E-25 T 13-10-2018 IPR023404 Radical SAM, alpha/beta horseshoe TOPB45_0967 efbafa3c23442dcf7c0e4e968a35e879 426 SMART SM00729 180 393 1.7E-34 T 13-10-2018 IPR006638 Elp3/MiaB/NifB GO:0003824|GO:0051536 TOPB45_0967 efbafa3c23442dcf7c0e4e968a35e879 426 Pfam PF02310 B12 binding domain 14 126 1.6E-19 T 13-10-2018 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 TOPB45_0967 efbafa3c23442dcf7c0e4e968a35e879 426 Pfam PF04055 Radical SAM superfamily 186 346 8.1E-26 T 13-10-2018 IPR007197 Radical SAM GO:0003824|GO:0051536 TOPB45_0967 efbafa3c23442dcf7c0e4e968a35e879 426 SUPERFAMILY SSF52242 23 133 5.57E-6 T 13-10-2018 IPR036724 Cobalamin-binding domain superfamily GO:0031419|GO:0046872 Reactome: R-HSA-196741 TOPB45_0967 efbafa3c23442dcf7c0e4e968a35e879 426 Gene3D G3DSA:3.40.50.280 20 142 1.8E-5 T 13-10-2018 TOPB45_0062 801cd755677a0e4e4180469af78d136e 234 SUPERFAMILY SSF160527 146 230 1.83E-6 T 13-10-2018 TOPB45_0062 801cd755677a0e4e4180469af78d136e 234 PRINTS PR01003 Flagellar assembly protein FliH signature 56 78 9.4E-6 T 13-10-2018 IPR000563 Flagellar assembly protein FliH GO:0003774|GO:0009288|GO:0071973 TOPB45_0062 801cd755677a0e4e4180469af78d136e 234 PRINTS PR01003 Flagellar assembly protein FliH signature 121 138 9.4E-6 T 13-10-2018 IPR000563 Flagellar assembly protein FliH GO:0003774|GO:0009288|GO:0071973 TOPB45_0062 801cd755677a0e4e4180469af78d136e 234 PRINTS PR01003 Flagellar assembly protein FliH signature 207 232 9.4E-6 T 13-10-2018 IPR000563 Flagellar assembly protein FliH GO:0003774|GO:0009288|GO:0071973 TOPB45_0062 801cd755677a0e4e4180469af78d136e 234 Pfam PF02108 Flagellar assembly protein FliH 101 225 1.9E-24 T 13-10-2018 IPR018035 Flagellar assembly protein FliH/Type III secretion system HrpE TOPB45_1421 8f20edae05739f42be87813c2e7a4170 223 SUPERFAMILY SSF53335 5 193 1.86E-32 T 13-10-2018 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TOPB45_1421 8f20edae05739f42be87813c2e7a4170 223 Pfam PF08241 Methyltransferase domain 49 134 3.1E-15 T 13-10-2018 IPR013216 Methyltransferase type 11 GO:0008168 TOPB45_1421 8f20edae05739f42be87813c2e7a4170 223 Gene3D G3DSA:3.40.50.150 2 210 1.4E-43 T 13-10-2018 TOPB45_1219 93f4f3a5ce5001467e59c1b882bbc0ed 153 Pfam PF00583 Acetyltransferase (GNAT) family 29 135 2.1E-21 T 13-10-2018 IPR000182 GNAT domain TOPB45_1219 93f4f3a5ce5001467e59c1b882bbc0ed 153 SUPERFAMILY SSF55729 1 141 5.24E-34 T 13-10-2018 IPR016181 Acyl-CoA N-acyltransferase TOPB45_1219 93f4f3a5ce5001467e59c1b882bbc0ed 153 Gene3D G3DSA:3.40.630.30 1 152 2.0E-43 T 13-10-2018 TOPB45_1011 91b9da3e866a88467dabad4aa2ed9c73 140 Hamap MF_00451 Nucleoside diphosphate kinase [ndk]. 1 136 34.746 T 13-10-2018 IPR001564 Nucleoside diphosphate kinase GO:0004550|GO:0006165|GO:0006183|GO:0006228|GO:0006241 KEGG: 00230+2.7.4.6|KEGG: 00240+2.7.4.6|KEGG: 00983+2.7.4.6|MetaCyc: PWY-6545|MetaCyc: PWY-7176|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7205|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7221|MetaCyc: PWY-7222|MetaCyc: PWY-7224|MetaCyc: PWY-7226|MetaCyc: PWY-7227 TOPB45_1011 91b9da3e866a88467dabad4aa2ed9c73 140 ProSitePatterns PS00469 Nucleoside diphosphate kinases active site. 112 120 - T 13-10-2018 IPR023005 Nucleoside diphosphate kinase, active site KEGG: 00230+2.7.4.6|KEGG: 00240+2.7.4.6|KEGG: 00983+2.7.4.6|MetaCyc: PWY-6545|MetaCyc: PWY-7176|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7205|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7221|MetaCyc: PWY-7222|MetaCyc: PWY-7224|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 TOPB45_1011 91b9da3e866a88467dabad4aa2ed9c73 140 Gene3D G3DSA:3.30.70.141 1 140 8.0E-60 T 13-10-2018 IPR036850 Nucleoside diphosphate kinase-like domain superfamily KEGG: 00230+2.7.4.6|KEGG: 00240+2.7.4.6|KEGG: 00983+2.7.4.6|MetaCyc: PWY-6545|MetaCyc: PWY-7176|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7205|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7221|MetaCyc: PWY-7222|MetaCyc: PWY-7224|MetaCyc: PWY-7226|MetaCyc: PWY-7227 TOPB45_1011 91b9da3e866a88467dabad4aa2ed9c73 140 SMART SM00562 1 138 1.3E-82 T 13-10-2018 IPR034907 Nucleoside diphosphate kinase-like domain KEGG: 00230+2.7.4.6|KEGG: 00240+2.7.4.6|KEGG: 00983+2.7.4.6|MetaCyc: PWY-6545|MetaCyc: PWY-7176|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7205|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7221|MetaCyc: PWY-7222|MetaCyc: PWY-7224|MetaCyc: PWY-7226|MetaCyc: PWY-7227 TOPB45_1011 91b9da3e866a88467dabad4aa2ed9c73 140 Pfam PF00334 Nucleoside diphosphate kinase 2 135 1.9E-56 T 13-10-2018 IPR034907 Nucleoside diphosphate kinase-like domain KEGG: 00230+2.7.4.6|KEGG: 00240+2.7.4.6|KEGG: 00983+2.7.4.6|MetaCyc: PWY-6545|MetaCyc: PWY-7176|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7205|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7221|MetaCyc: PWY-7222|MetaCyc: PWY-7224|MetaCyc: PWY-7226|MetaCyc: PWY-7227 TOPB45_1011 91b9da3e866a88467dabad4aa2ed9c73 140 SUPERFAMILY SSF54919 1 136 8.64E-58 T 13-10-2018 IPR036850 Nucleoside diphosphate kinase-like domain superfamily KEGG: 00230+2.7.4.6|KEGG: 00240+2.7.4.6|KEGG: 00983+2.7.4.6|MetaCyc: PWY-6545|MetaCyc: PWY-7176|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7205|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7221|MetaCyc: PWY-7222|MetaCyc: PWY-7224|MetaCyc: PWY-7226|MetaCyc: PWY-7227 TOPB45_1011 91b9da3e866a88467dabad4aa2ed9c73 140 PRINTS PR01243 Nucleoside diphosphate kinase signature 112 131 2.1E-39 T 13-10-2018 IPR001564 Nucleoside diphosphate kinase GO:0004550|GO:0006165|GO:0006183|GO:0006228|GO:0006241 KEGG: 00230+2.7.4.6|KEGG: 00240+2.7.4.6|KEGG: 00983+2.7.4.6|MetaCyc: PWY-6545|MetaCyc: PWY-7176|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7205|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7221|MetaCyc: PWY-7222|MetaCyc: PWY-7224|MetaCyc: PWY-7226|MetaCyc: PWY-7227 TOPB45_1011 91b9da3e866a88467dabad4aa2ed9c73 140 PRINTS PR01243 Nucleoside diphosphate kinase signature 48 67 2.1E-39 T 13-10-2018 IPR001564 Nucleoside diphosphate kinase GO:0004550|GO:0006165|GO:0006183|GO:0006228|GO:0006241 KEGG: 00230+2.7.4.6|KEGG: 00240+2.7.4.6|KEGG: 00983+2.7.4.6|MetaCyc: PWY-6545|MetaCyc: PWY-7176|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7205|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7221|MetaCyc: PWY-7222|MetaCyc: PWY-7224|MetaCyc: PWY-7226|MetaCyc: PWY-7227 TOPB45_1011 91b9da3e866a88467dabad4aa2ed9c73 140 PRINTS PR01243 Nucleoside diphosphate kinase signature 68 85 2.1E-39 T 13-10-2018 IPR001564 Nucleoside diphosphate kinase GO:0004550|GO:0006165|GO:0006183|GO:0006228|GO:0006241 KEGG: 00230+2.7.4.6|KEGG: 00240+2.7.4.6|KEGG: 00983+2.7.4.6|MetaCyc: PWY-6545|MetaCyc: PWY-7176|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7205|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7221|MetaCyc: PWY-7222|MetaCyc: PWY-7224|MetaCyc: PWY-7226|MetaCyc: PWY-7227 TOPB45_1011 91b9da3e866a88467dabad4aa2ed9c73 140 PRINTS PR01243 Nucleoside diphosphate kinase signature 89 105 2.1E-39 T 13-10-2018 IPR001564 Nucleoside diphosphate kinase GO:0004550|GO:0006165|GO:0006183|GO:0006228|GO:0006241 KEGG: 00230+2.7.4.6|KEGG: 00240+2.7.4.6|KEGG: 00983+2.7.4.6|MetaCyc: PWY-6545|MetaCyc: PWY-7176|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7205|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7221|MetaCyc: PWY-7222|MetaCyc: PWY-7224|MetaCyc: PWY-7226|MetaCyc: PWY-7227 TOPB45_1011 91b9da3e866a88467dabad4aa2ed9c73 140 PRINTS PR01243 Nucleoside diphosphate kinase signature 4 26 2.1E-39 T 13-10-2018 IPR001564 Nucleoside diphosphate kinase GO:0004550|GO:0006165|GO:0006183|GO:0006228|GO:0006241 KEGG: 00230+2.7.4.6|KEGG: 00240+2.7.4.6|KEGG: 00983+2.7.4.6|MetaCyc: PWY-6545|MetaCyc: PWY-7176|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7205|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7221|MetaCyc: PWY-7222|MetaCyc: PWY-7224|MetaCyc: PWY-7226|MetaCyc: PWY-7227 TOPB45_0542 12a8689d5c0defa25d74922b70a23853 113 Pfam PF13411 MerR HTH family regulatory protein 13 79 1.8E-15 T 13-10-2018 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TOPB45_0542 12a8689d5c0defa25d74922b70a23853 113 Gene3D G3DSA:1.10.1660.10 1 83 1.9E-14 T 13-10-2018 TOPB45_0542 12a8689d5c0defa25d74922b70a23853 113 SMART SM00422 12 80 0.0029 T 13-10-2018 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 TOPB45_0542 12a8689d5c0defa25d74922b70a23853 113 SUPERFAMILY SSF46955 12 109 7.33E-11 T 13-10-2018 IPR009061 Putative DNA-binding domain superfamily TOPB45_1562 21da9f02dc45f51ed2233ef9584f6c42 600 Gene3D G3DSA:3.30.450.20 479 585 2.2E-18 T 13-10-2018 TOPB45_1562 21da9f02dc45f51ed2233ef9584f6c42 600 SUPERFAMILY SSF51569 45 342 8.42E-56 T 13-10-2018 TOPB45_1562 21da9f02dc45f51ed2233ef9584f6c42 600 Pfam PF00682 HMGL-like 49 323 5.7E-32 T 13-10-2018 IPR000891 Pyruvate carboxyltransferase GO:0003824 TOPB45_1562 21da9f02dc45f51ed2233ef9584f6c42 600 SUPERFAMILY SSF103190 467 595 9.68E-12 T 13-10-2018 IPR029151 Periplasmic sensor-like domain superfamily TOPB45_1562 21da9f02dc45f51ed2233ef9584f6c42 600 Gene3D G3DSA:3.20.20.70 42 371 5.6E-72 T 13-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 TOPB45_1562 21da9f02dc45f51ed2233ef9584f6c42 600 Pfam PF02743 Cache domain 459 591 2.3E-17 T 13-10-2018 IPR033479 Double Cache domain 1 TOPB45_0219 60067f2890f71eaeaf19e72a1fa06e24 304 Hamap MF_00185 tRNA dimethylallyltransferase [miaA]. 4 298 30.323 T 13-10-2018 IPR018022 IPP transferase GO:0008033 KEGG: 00908+2.5.1.75|MetaCyc: PWY-2781|Reactome: R-HSA-6782315|Reactome: R-HSA-6787450 TOPB45_0219 60067f2890f71eaeaf19e72a1fa06e24 304 Gene3D G3DSA:1.10.20.140 111 180 1.1E-101 T 13-10-2018 TOPB45_0219 60067f2890f71eaeaf19e72a1fa06e24 304 SUPERFAMILY SSF52540 3 268 1.17E-6 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0219 60067f2890f71eaeaf19e72a1fa06e24 304 Gene3D G3DSA:3.40.50.300 8 285 1.1E-101 T 13-10-2018 TOPB45_0219 60067f2890f71eaeaf19e72a1fa06e24 304 SUPERFAMILY SSF52540 4 147 1.84E-21 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0219 60067f2890f71eaeaf19e72a1fa06e24 304 Pfam PF01715 IPP transferase 37 281 2.0E-81 T 13-10-2018 IPR018022 IPP transferase GO:0008033 KEGG: 00908+2.5.1.75|MetaCyc: PWY-2781|Reactome: R-HSA-6782315|Reactome: R-HSA-6787450 TOPB45_0219 60067f2890f71eaeaf19e72a1fa06e24 304 TIGRFAM TIGR00174 miaA: tRNA dimethylallyltransferase 4 289 1.4E-95 T 13-10-2018 IPR018022 IPP transferase GO:0008033 KEGG: 00908+2.5.1.75|MetaCyc: PWY-2781|Reactome: R-HSA-6782315|Reactome: R-HSA-6787450 TOPB45_0960 905c0120acbc7d357fe694acd648fa55 400 Hamap MF_00179 GTP cyclohydrolase-2 [ribA]. 204 398 41.656 T 13-10-2018 IPR000926 GTP cyclohydrolase II, RibA GO:0003935|GO:0009231 KEGG: 00740+3.5.4.25|KEGG: 00790+3.5.4.25|MetaCyc: PWY-6168|MetaCyc: PWY-7539|MetaCyc: PWY-7991 TOPB45_0960 905c0120acbc7d357fe694acd648fa55 400 Gene3D G3DSA:3.40.50.10990 206 375 1.1E-77 T 13-10-2018 IPR036144 RibA-like superfamily KEGG: 00740+3.5.4.25|KEGG: 00790+3.5.4.25|MetaCyc: PWY-6168|MetaCyc: PWY-7539|MetaCyc: PWY-7991 TOPB45_0960 905c0120acbc7d357fe694acd648fa55 400 Pfam PF00925 GTP cyclohydrolase II 208 372 4.2E-78 T 13-10-2018 IPR032677 GTP cyclohydrolase II KEGG: 00740+3.5.4.25|KEGG: 00790+3.5.4.25|MetaCyc: PWY-6168|MetaCyc: PWY-7539|MetaCyc: PWY-7991 TOPB45_0960 905c0120acbc7d357fe694acd648fa55 400 TIGRFAM TIGR00506 ribB: 3,4-dihydroxy-2-butanone-4-phosphate synthase 3 199 8.8E-80 T 13-10-2018 IPR000422 3,4-dihydroxy-2-butanone 4-phosphate synthase, RibB GO:0008686|GO:0009231 KEGG: 00740+4.1.99.12|MetaCyc: PWY-6167|MetaCyc: PWY-6168 TOPB45_0960 905c0120acbc7d357fe694acd648fa55 400 Hamap MF_00180 3,4-dihydroxy-2-butanone 4-phosphate synthase [ribB]. 1 203 40.856 T 13-10-2018 IPR000422 3,4-dihydroxy-2-butanone 4-phosphate synthase, RibB GO:0008686|GO:0009231 KEGG: 00740+4.1.99.12|MetaCyc: PWY-6167|MetaCyc: PWY-6168 TOPB45_0960 905c0120acbc7d357fe694acd648fa55 400 SUPERFAMILY SSF142695 204 375 1.57E-74 T 13-10-2018 IPR036144 RibA-like superfamily KEGG: 00740+3.5.4.25|KEGG: 00790+3.5.4.25|MetaCyc: PWY-6168|MetaCyc: PWY-7539|MetaCyc: PWY-7991 TOPB45_0960 905c0120acbc7d357fe694acd648fa55 400 PIRSF PIRSF001259 1 399 1.2E-185 T 13-10-2018 TOPB45_0960 905c0120acbc7d357fe694acd648fa55 400 TIGRFAM TIGR00505 ribA: GTP cyclohydrolase II 209 396 1.4E-80 T 13-10-2018 IPR000926 GTP cyclohydrolase II, RibA GO:0003935|GO:0009231 KEGG: 00740+3.5.4.25|KEGG: 00790+3.5.4.25|MetaCyc: PWY-6168|MetaCyc: PWY-7539|MetaCyc: PWY-7991 TOPB45_0960 905c0120acbc7d357fe694acd648fa55 400 Gene3D G3DSA:3.90.870.10 1 205 1.2E-93 T 13-10-2018 TOPB45_0960 905c0120acbc7d357fe694acd648fa55 400 SUPERFAMILY SSF55821 4 206 6.87E-89 T 13-10-2018 IPR017945 DHBP synthase RibB-like alpha/beta domain superfamily TOPB45_0960 905c0120acbc7d357fe694acd648fa55 400 Hamap MF_01283 Riboflavin biosynthesis protein RibBA [ribBA]. 2 394 55.8 T 13-10-2018 IPR016299 Riboflavin biosynthesis protein RibBA GO:0009231 KEGG: 00740+3.5.4.25+4.1.99.12|KEGG: 00790+3.5.4.25|MetaCyc: PWY-6167|MetaCyc: PWY-6168|MetaCyc: PWY-7539|MetaCyc: PWY-7991 TOPB45_0960 905c0120acbc7d357fe694acd648fa55 400 Pfam PF00926 3,4-dihydroxy-2-butanone 4-phosphate synthase 7 198 6.5E-88 T 13-10-2018 IPR000422 3,4-dihydroxy-2-butanone 4-phosphate synthase, RibB GO:0008686|GO:0009231 KEGG: 00740+4.1.99.12|MetaCyc: PWY-6167|MetaCyc: PWY-6168 TOPB45_0837 929eb3f463457f2758f10ca8053e19fd 402 SUPERFAMILY SSF47729 1 91 9.13E-23 T 13-10-2018 IPR010992 Integration host factor (IHF)-like DNA-binding domain superfamily GO:0003677 TOPB45_0837 929eb3f463457f2758f10ca8053e19fd 402 Gene3D G3DSA:3.30.420.150 222 398 1.7E-42 T 13-10-2018 TOPB45_0837 929eb3f463457f2758f10ca8053e19fd 402 SUPERFAMILY SSF53067 94 214 2.98E-29 T 13-10-2018 TOPB45_0837 929eb3f463457f2758f10ca8053e19fd 402 Pfam PF02541 Ppx/GppA phosphatase family 119 394 5.8E-55 T 13-10-2018 IPR003695 Ppx/GppA phosphatase KEGG: 00230+3.6.1.40 TOPB45_0837 929eb3f463457f2758f10ca8053e19fd 402 SMART SM00411 1 91 5.5E-20 T 13-10-2018 IPR000119 Histone-like DNA-binding protein GO:0003677 TOPB45_0837 929eb3f463457f2758f10ca8053e19fd 402 SUPERFAMILY SSF53067 222 397 4.06E-35 T 13-10-2018 TOPB45_0837 929eb3f463457f2758f10ca8053e19fd 402 Pfam PF00216 Bacterial DNA-binding protein 1 91 5.6E-22 T 13-10-2018 IPR000119 Histone-like DNA-binding protein GO:0003677 TOPB45_0837 929eb3f463457f2758f10ca8053e19fd 402 Gene3D G3DSA:4.10.520.10 1 88 8.4E-22 T 13-10-2018 IPR010992 Integration host factor (IHF)-like DNA-binding domain superfamily GO:0003677 TOPB45_0837 929eb3f463457f2758f10ca8053e19fd 402 Gene3D G3DSA:3.30.420.40 89 213 1.5E-33 T 13-10-2018 TOPB45_0257 b32786fd29b37339b3b95c363a57760b 495 Gene3D G3DSA:2.30.42.10 283 386 5.1E-32 T 13-10-2018 TOPB45_0257 b32786fd29b37339b3b95c363a57760b 495 Gene3D G3DSA:2.40.10.120 61 281 1.4E-86 T 13-10-2018 TOPB45_0257 b32786fd29b37339b3b95c363a57760b 495 TIGRFAM TIGR02037 degP_htrA_DO: peptidase Do 62 489 1.2E-153 T 13-10-2018 IPR011782 Peptidase S1C, Do GO:0004252|GO:0006508 TOPB45_0257 b32786fd29b37339b3b95c363a57760b 495 Gene3D G3DSA:2.30.42.10 401 495 1.8E-15 T 13-10-2018 TOPB45_0257 b32786fd29b37339b3b95c363a57760b 495 SMART SM00228 401 483 3.9E-5 T 13-10-2018 IPR001478 PDZ domain GO:0005515 TOPB45_0257 b32786fd29b37339b3b95c363a57760b 495 SMART SM00228 288 370 8.8E-18 T 13-10-2018 IPR001478 PDZ domain GO:0005515 TOPB45_0257 b32786fd29b37339b3b95c363a57760b 495 Pfam PF13180 PDZ domain 288 378 5.4E-19 T 13-10-2018 IPR001478 PDZ domain GO:0005515 TOPB45_0257 b32786fd29b37339b3b95c363a57760b 495 PRINTS PR00834 HtrA/DegQ protease family signature 220 237 1.4E-54 T 13-10-2018 IPR001940 Peptidase S1C GO:0004252|GO:0006508 TOPB45_0257 b32786fd29b37339b3b95c363a57760b 495 PRINTS PR00834 HtrA/DegQ protease family signature 242 259 1.4E-54 T 13-10-2018 IPR001940 Peptidase S1C GO:0004252|GO:0006508 TOPB45_0257 b32786fd29b37339b3b95c363a57760b 495 PRINTS PR00834 HtrA/DegQ protease family signature 124 136 1.4E-54 T 13-10-2018 IPR001940 Peptidase S1C GO:0004252|GO:0006508 TOPB45_0257 b32786fd29b37339b3b95c363a57760b 495 PRINTS PR00834 HtrA/DegQ protease family signature 185 209 1.4E-54 T 13-10-2018 IPR001940 Peptidase S1C GO:0004252|GO:0006508 TOPB45_0257 b32786fd29b37339b3b95c363a57760b 495 PRINTS PR00834 HtrA/DegQ protease family signature 328 340 1.4E-54 T 13-10-2018 IPR001940 Peptidase S1C GO:0004252|GO:0006508 TOPB45_0257 b32786fd29b37339b3b95c363a57760b 495 PRINTS PR00834 HtrA/DegQ protease family signature 145 165 1.4E-54 T 13-10-2018 IPR001940 Peptidase S1C GO:0004252|GO:0006508 TOPB45_0257 b32786fd29b37339b3b95c363a57760b 495 Pfam PF13365 Trypsin-like peptidase domain 115 249 3.7E-32 T 13-10-2018 TOPB45_0257 b32786fd29b37339b3b95c363a57760b 495 SUPERFAMILY SSF50156 246 371 1.84E-27 T 13-10-2018 IPR036034 PDZ superfamily GO:0005515 TOPB45_0257 b32786fd29b37339b3b95c363a57760b 495 SUPERFAMILY SSF50494 64 280 1.1E-69 T 13-10-2018 IPR009003 Peptidase S1, PA clan TOPB45_0257 b32786fd29b37339b3b95c363a57760b 495 SUPERFAMILY SSF50156 403 492 6.84E-14 T 13-10-2018 IPR036034 PDZ superfamily GO:0005515 TOPB45_0962 858cc568c9ba556985834a01345419c5 301 Pfam PF00535 Glycosyl transferase family 2 13 129 1.1E-38 T 13-10-2018 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 TOPB45_0962 858cc568c9ba556985834a01345419c5 301 Gene3D G3DSA:3.90.550.10 1 269 9.1E-73 T 13-10-2018 IPR029044 Nucleotide-diphospho-sugar transferases TOPB45_0962 858cc568c9ba556985834a01345419c5 301 SUPERFAMILY SSF53448 10 233 2.42E-68 T 13-10-2018 IPR029044 Nucleotide-diphospho-sugar transferases TOPB45_1323 82130457d3bc2b39567c584790bb560d 104 Gene3D G3DSA:1.10.10.60 63 100 2.9E-6 T 13-10-2018 TOPB45_0210 a3147593681f3bc6f841c3cce22c40ad 368 SUPERFAMILY SSF51569 1 356 4.58E-70 T 13-10-2018 TOPB45_0210 a3147593681f3bc6f841c3cce22c40ad 368 Pfam PF00793 DAHP synthetase I family 98 351 4.3E-43 T 13-10-2018 IPR006218 DAHP synthetase I/KDSA GO:0009058 KEGG: 00540+2.5.1.55|MetaCyc: PWY-1269|MetaCyc: PWY-7674 TOPB45_0210 a3147593681f3bc6f841c3cce22c40ad 368 Gene3D G3DSA:3.30.70.1140 1 84 1.7E-8 T 13-10-2018 TOPB45_0210 a3147593681f3bc6f841c3cce22c40ad 368 Gene3D G3DSA:3.20.20.70 86 355 1.1E-69 T 13-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 TOPB45_0411 5c15ab2a01930d699a7ecbe5eae1b864 313 Gene3D G3DSA:3.30.420.40 2 304 6.3E-79 T 13-10-2018 TOPB45_0411 5c15ab2a01930d699a7ecbe5eae1b864 313 SUPERFAMILY SSF53067 3 310 1.1E-42 T 13-10-2018 TOPB45_0411 5c15ab2a01930d699a7ecbe5eae1b864 313 Gene3D G3DSA:3.40.367.20 99 294 6.3E-79 T 13-10-2018 TOPB45_0411 5c15ab2a01930d699a7ecbe5eae1b864 313 Pfam PF02685 Glucokinase 3 310 1.7E-73 T 13-10-2018 IPR003836 Glucokinase GO:0004340|GO:0005524|GO:0005536|GO:0006096|GO:0051156 KEGG: 00010+2.7.1.2|KEGG: 00052+2.7.1.2|KEGG: 00500+2.7.1.2|KEGG: 00520+2.7.1.2|KEGG: 00521+2.7.1.2|KEGG: 00524+2.7.1.2|MetaCyc: PWY-2722|MetaCyc: PWY-2723|MetaCyc: PWY-5514|MetaCyc: PWY-5661|MetaCyc: PWY-621|MetaCyc: PWY-7238|MetaCyc: PWY-7385 TOPB45_0372 7bf2cfaf1d52887b32243a28f110709c 802 SMART SM00434 7 461 2.0E-273 T 13-10-2018 IPR002205 DNA topoisomerase, type IIA, subunit A/C-terminal GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TOPB45_0372 7bf2cfaf1d52887b32243a28f110709c 802 SUPERFAMILY SSF101904 498 798 3.01E-71 T 13-10-2018 IPR035516 DNA gyrase/topoisomerase IV, subunit A, C-terminal TOPB45_0372 7bf2cfaf1d52887b32243a28f110709c 802 Gene3D G3DSA:1.10.268.10 366 462 3.6E-210 T 13-10-2018 IPR013757 Type IIA DNA topoisomerase subunit A, alpha-helical domain superfamily GO:0003677|GO:0003918|GO:0005524 Reactome: R-HSA-4615885 TOPB45_0372 7bf2cfaf1d52887b32243a28f110709c 802 Gene3D G3DSA:2.120.10.90 494 797 1.1E-82 T 13-10-2018 IPR035516 DNA gyrase/topoisomerase IV, subunit A, C-terminal TOPB45_0372 7bf2cfaf1d52887b32243a28f110709c 802 SUPERFAMILY SSF56719 26 484 3.01E-177 T 13-10-2018 IPR013760 DNA topoisomerase, type IIA-like domain superfamily GO:0003918|GO:0005524 Reactome: R-HSA-4615885 TOPB45_0372 7bf2cfaf1d52887b32243a28f110709c 802 Gene3D G3DSA:3.90.199.10 29 483 3.6E-210 T 13-10-2018 IPR013758 DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta GO:0003677|GO:0003918|GO:0005524|GO:0006259|GO:0006265 Reactome: R-HSA-4615885 TOPB45_0372 7bf2cfaf1d52887b32243a28f110709c 802 Pfam PF03989 DNA gyrase C-terminal domain, beta-propeller 701 743 4.4E-10 T 13-10-2018 IPR006691 DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat GO:0003677|GO:0003916|GO:0005524|GO:0005694|GO:0006265 TOPB45_0372 7bf2cfaf1d52887b32243a28f110709c 802 Pfam PF03989 DNA gyrase C-terminal domain, beta-propeller 604 646 5.5E-4 T 13-10-2018 IPR006691 DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat GO:0003677|GO:0003916|GO:0005524|GO:0005694|GO:0006265 TOPB45_0372 7bf2cfaf1d52887b32243a28f110709c 802 Pfam PF03989 DNA gyrase C-terminal domain, beta-propeller 504 530 7.9E-4 T 13-10-2018 IPR006691 DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat GO:0003677|GO:0003916|GO:0005524|GO:0005694|GO:0006265 TOPB45_0372 7bf2cfaf1d52887b32243a28f110709c 802 Pfam PF03989 DNA gyrase C-terminal domain, beta-propeller 651 693 8.6E-6 T 13-10-2018 IPR006691 DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat GO:0003677|GO:0003916|GO:0005524|GO:0005694|GO:0006265 TOPB45_0372 7bf2cfaf1d52887b32243a28f110709c 802 Pfam PF03989 DNA gyrase C-terminal domain, beta-propeller 752 797 2.1E-9 T 13-10-2018 IPR006691 DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat GO:0003677|GO:0003916|GO:0005524|GO:0005694|GO:0006265 TOPB45_0372 7bf2cfaf1d52887b32243a28f110709c 802 Pfam PF03989 DNA gyrase C-terminal domain, beta-propeller 554 583 4.5 T 13-10-2018 IPR006691 DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat GO:0003677|GO:0003916|GO:0005524|GO:0005694|GO:0006265 TOPB45_0372 7bf2cfaf1d52887b32243a28f110709c 802 Pfam PF00521 DNA gyrase/topoisomerase IV, subunit A 28 468 1.1E-159 T 13-10-2018 IPR002205 DNA topoisomerase, type IIA, subunit A/C-terminal GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 TOPB45_0372 7bf2cfaf1d52887b32243a28f110709c 802 Gene3D G3DSA:3.30.1360.40 232 329 3.6E-210 T 13-10-2018 TOPB45_0372 7bf2cfaf1d52887b32243a28f110709c 802 Hamap MF_01897 DNA gyrase subunit A [gyrA]. 1 799 22.265 T 13-10-2018 IPR005743 DNA gyrase, subunit A GO:0003677|GO:0003918|GO:0005524|GO:0005694|GO:0006265 TOPB45_0372 7bf2cfaf1d52887b32243a28f110709c 802 TIGRFAM TIGR01063 gyrA: DNA gyrase, A subunit 4 797 0.0 T 13-10-2018 TOPB45_1530 b4bba4a8390788191cbcc36f3d80f026 255 SUPERFAMILY SSF55120 9 228 3.52E-53 T 13-10-2018 IPR020103 Pseudouridine synthase, catalytic domain superfamily GO:0001522|GO:0003723|GO:0009451|GO:0009982 TOPB45_1530 b4bba4a8390788191cbcc36f3d80f026 255 Gene3D G3DSA:3.30.2350.10 8 230 3.4E-54 T 13-10-2018 TOPB45_1530 b4bba4a8390788191cbcc36f3d80f026 255 Pfam PF00849 RNA pseudouridylate synthase 17 170 8.4E-27 T 13-10-2018 IPR006145 Pseudouridine synthase, RsuA/RluB/C/D/E/F GO:0001522|GO:0003723|GO:0009451|GO:0009982 TOPB45_0101 de4988f6804f8b0a2198fbcb187e3ea3 152 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 77 88 - T 13-10-2018 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site TOPB45_0101 de4988f6804f8b0a2198fbcb187e3ea3 152 Gene3D G3DSA:3.30.70.20 30 150 9.8E-35 T 13-10-2018 TOPB45_0101 de4988f6804f8b0a2198fbcb187e3ea3 152 Pfam PF13247 4Fe-4S dicluster domain 45 131 2.4E-21 T 13-10-2018 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain TOPB45_0101 de4988f6804f8b0a2198fbcb187e3ea3 152 SUPERFAMILY SSF54862 2 134 6.87E-42 T 13-10-2018 TOPB45_0061 65348daac59ec4e31e433f4ee55cb927 336 Gene3D G3DSA:1.10.220.30 1 87 5.3E-20 T 13-10-2018 TOPB45_0061 65348daac59ec4e31e433f4ee55cb927 336 TIGRFAM TIGR00207 fliG: flagellar motor switch protein FliG 1 334 6.4E-96 T 13-10-2018 IPR000090 Flagellar motor switch protein FliG GO:0003774|GO:0006935|GO:0009288|GO:0071973 TOPB45_0061 65348daac59ec4e31e433f4ee55cb927 336 SUPERFAMILY SSF48029 8 115 6.02E-15 T 13-10-2018 IPR011002 Flagellar motor switch protein FliG, alpha-helical TOPB45_0061 65348daac59ec4e31e433f4ee55cb927 336 Gene3D G3DSA:1.10.220.30 199 336 9.5E-47 T 13-10-2018 TOPB45_0061 65348daac59ec4e31e433f4ee55cb927 336 Pfam PF14842 FliG N-terminal domain 8 108 1.5E-22 T 13-10-2018 IPR028263 Flagellar motor switch protein FliG, N-terminal domain TOPB45_0061 65348daac59ec4e31e433f4ee55cb927 336 Gene3D G3DSA:1.10.220.30 94 195 8.8E-31 T 13-10-2018 TOPB45_0061 65348daac59ec4e31e433f4ee55cb927 336 SUPERFAMILY SSF48029 118 329 1.14E-63 T 13-10-2018 IPR011002 Flagellar motor switch protein FliG, alpha-helical TOPB45_0061 65348daac59ec4e31e433f4ee55cb927 336 PIRSF PIRSF003161 3 336 5.3E-114 T 13-10-2018 IPR000090 Flagellar motor switch protein FliG GO:0003774|GO:0006935|GO:0009288|GO:0071973 TOPB45_0061 65348daac59ec4e31e433f4ee55cb927 336 Pfam PF01706 FliG C-terminal domain 222 328 2.4E-40 T 13-10-2018 IPR023087 Flagellar motor switch protein FliG, C-terminal TOPB45_0061 65348daac59ec4e31e433f4ee55cb927 336 Pfam PF14841 FliG middle domain 119 191 1.3E-26 T 13-10-2018 IPR032779 Flagellar motor switch protein FliG, middle domain TOPB45_0061 65348daac59ec4e31e433f4ee55cb927 336 PRINTS PR00954 Flagellar motor switch protein FliG signature 230 250 1.6E-64 T 13-10-2018 IPR000090 Flagellar motor switch protein FliG GO:0003774|GO:0006935|GO:0009288|GO:0071973 TOPB45_0061 65348daac59ec4e31e433f4ee55cb927 336 PRINTS PR00954 Flagellar motor switch protein FliG signature 38 64 1.6E-64 T 13-10-2018 IPR000090 Flagellar motor switch protein FliG GO:0003774|GO:0006935|GO:0009288|GO:0071973 TOPB45_0061 65348daac59ec4e31e433f4ee55cb927 336 PRINTS PR00954 Flagellar motor switch protein FliG signature 276 302 1.6E-64 T 13-10-2018 IPR000090 Flagellar motor switch protein FliG GO:0003774|GO:0006935|GO:0009288|GO:0071973 TOPB45_0061 65348daac59ec4e31e433f4ee55cb927 336 PRINTS PR00954 Flagellar motor switch protein FliG signature 118 141 1.6E-64 T 13-10-2018 IPR000090 Flagellar motor switch protein FliG GO:0003774|GO:0006935|GO:0009288|GO:0071973 TOPB45_0061 65348daac59ec4e31e433f4ee55cb927 336 PRINTS PR00954 Flagellar motor switch protein FliG signature 9 25 1.6E-64 T 13-10-2018 IPR000090 Flagellar motor switch protein FliG GO:0003774|GO:0006935|GO:0009288|GO:0071973 TOPB45_0061 65348daac59ec4e31e433f4ee55cb927 336 PRINTS PR00954 Flagellar motor switch protein FliG signature 252 272 1.6E-64 T 13-10-2018 IPR000090 Flagellar motor switch protein FliG GO:0003774|GO:0006935|GO:0009288|GO:0071973 TOPB45_0061 65348daac59ec4e31e433f4ee55cb927 336 PRINTS PR00954 Flagellar motor switch protein FliG signature 199 224 1.6E-64 T 13-10-2018 IPR000090 Flagellar motor switch protein FliG GO:0003774|GO:0006935|GO:0009288|GO:0071973 TOPB45_0262 9676e20520df4bd0c9bb0a20867a4f3e 426 Pfam PF01979 Amidohydrolase family 52 417 2.9E-19 T 13-10-2018 IPR006680 Amidohydrolase-related GO:0016787 TOPB45_0262 9676e20520df4bd0c9bb0a20867a4f3e 426 Hamap MF_00220_B Dihydroorotase [pyrC]. 3 424 41.353 T 13-10-2018 IPR004722 Dihydroorotase GO:0004151|GO:0006221|GO:0046872 KEGG: 00240+3.5.2.3|MetaCyc: PWY-5686|MetaCyc: PWY-7790|MetaCyc: PWY-7791 TOPB45_0262 9676e20520df4bd0c9bb0a20867a4f3e 426 SUPERFAMILY SSF51338 3 417 5.92E-22 T 13-10-2018 IPR011059 Metal-dependent hydrolase, composite domain superfamily GO:0016810 TOPB45_0262 9676e20520df4bd0c9bb0a20867a4f3e 426 SUPERFAMILY SSF51556 56 366 2.52E-98 T 13-10-2018 IPR032466 Metal-dependent hydrolase TOPB45_0262 9676e20520df4bd0c9bb0a20867a4f3e 426 TIGRFAM TIGR00857 pyrC_multi: dihydroorotase, multifunctional complex type 21 420 2.9E-123 T 13-10-2018 TOPB45_0262 9676e20520df4bd0c9bb0a20867a4f3e 426 ProSitePatterns PS00483 Dihydroorotase signature 2. 304 315 - T 13-10-2018 IPR002195 Dihydroorotase, conserved site GO:0016812 KEGG: 00240+3.5.2.3|MetaCyc: PWY-5686|MetaCyc: PWY-7790|MetaCyc: PWY-7791 TOPB45_0262 9676e20520df4bd0c9bb0a20867a4f3e 426 ProSitePatterns PS00482 Dihydroorotase signature 1. 59 67 - T 13-10-2018 IPR002195 Dihydroorotase, conserved site GO:0016812 KEGG: 00240+3.5.2.3|MetaCyc: PWY-5686|MetaCyc: PWY-7790|MetaCyc: PWY-7791 TOPB45_0262 9676e20520df4bd0c9bb0a20867a4f3e 426 Gene3D G3DSA:2.30.40.10 9 417 1.5E-128 T 13-10-2018 IPR011059 Metal-dependent hydrolase, composite domain superfamily GO:0016810 TOPB45_0262 9676e20520df4bd0c9bb0a20867a4f3e 426 Gene3D G3DSA:3.20.20.140 57 368 1.5E-128 T 13-10-2018 TOPB45_0449 e66ce64c60c707fa469c459151b8db1d 404 SUPERFAMILY SSF53686 4 392 1.96E-153 T 13-10-2018 IPR036052 Tryptophan synthase beta subunit-like PLP-dependent enzyme TOPB45_0449 e66ce64c60c707fa469c459151b8db1d 404 TIGRFAM TIGR00263 trpB: tryptophan synthase, beta subunit 8 392 3.2E-193 T 13-10-2018 IPR006654 Tryptophan synthase, beta chain GO:0004834|GO:0006568 KEGG: 00260+4.2.1.20|KEGG: 00400+4.2.1.20 TOPB45_0449 e66ce64c60c707fa469c459151b8db1d 404 Gene3D G3DSA:3.40.50.1100 11 208 1.4E-188 T 13-10-2018 TOPB45_0449 e66ce64c60c707fa469c459151b8db1d 404 Hamap MF_00133 Tryptophan synthase beta chain [trpB]. 3 393 53.515 T 13-10-2018 IPR023026 Tryptophan synthase beta chain/beta chain-like GO:0000162|GO:0004834 KEGG: 00260+4.2.1.20|KEGG: 00400+4.2.1.20 TOPB45_0449 e66ce64c60c707fa469c459151b8db1d 404 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 53 380 5.6E-50 T 13-10-2018 IPR001926 Pyridoxal-phosphate dependent enzyme TOPB45_0449 e66ce64c60c707fa469c459151b8db1d 404 Gene3D G3DSA:3.40.50.1100 55 386 1.4E-188 T 13-10-2018 TOPB45_0449 e66ce64c60c707fa469c459151b8db1d 404 ProSitePatterns PS00168 Tryptophan synthase beta chain pyridoxal-phosphate attachment site. 83 97 - T 13-10-2018 IPR006653 Tryptophan synthase, beta chain, conserved site GO:0004834|GO:0006568 KEGG: 00260+4.2.1.20|KEGG: 00400+4.2.1.20 TOPB45_0449 e66ce64c60c707fa469c459151b8db1d 404 PIRSF PIRSF001413 1 399 8.0E-170 T 13-10-2018 IPR023026 Tryptophan synthase beta chain/beta chain-like GO:0000162|GO:0004834 KEGG: 00260+4.2.1.20|KEGG: 00400+4.2.1.20 TOPB45_0673 c342f2223725a812a8222c3718aa63c7 69 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 48 59 - T 13-10-2018 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site TOPB45_0673 c342f2223725a812a8222c3718aa63c7 69 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 11 22 - T 13-10-2018 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site TOPB45_0673 c342f2223725a812a8222c3718aa63c7 69 SUPERFAMILY SSF54862 3 60 3.49E-13 T 13-10-2018 TOPB45_0673 c342f2223725a812a8222c3718aa63c7 69 Gene3D G3DSA:3.30.70.20 2 68 2.0E-12 T 13-10-2018 TOPB45_0673 c342f2223725a812a8222c3718aa63c7 69 Pfam PF12838 4Fe-4S dicluster domain 10 59 3.2E-8 T 13-10-2018 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain TOPB45_1033 0fa2d457bc14c29d9322906495ccbe2d 498 Gene3D G3DSA:3.40.50.300 8 97 1.9E-21 T 13-10-2018 TOPB45_1033 0fa2d457bc14c29d9322906495ccbe2d 498 Pfam PF13361 UvrD-like helicase C-terminal domain 381 456 1.3E-15 T 13-10-2018 IPR014017 UvrD-like DNA helicase, C-terminal GO:0005524|GO:0016787 TOPB45_1033 0fa2d457bc14c29d9322906495ccbe2d 498 Gene3D G3DSA:3.40.50.300 263 365 3.9E-5 T 13-10-2018 TOPB45_1033 0fa2d457bc14c29d9322906495ccbe2d 498 Gene3D G3DSA:3.40.50.300 123 239 3.9E-18 T 13-10-2018 TOPB45_1033 0fa2d457bc14c29d9322906495ccbe2d 498 Gene3D G3DSA:1.10.10.160 98 115 1.9E-21 T 13-10-2018 IPR013986 DExx box DNA helicase domain superfamily TOPB45_1033 0fa2d457bc14c29d9322906495ccbe2d 498 Gene3D G3DSA:3.40.50.300 366 484 7.5E-18 T 13-10-2018 TOPB45_1033 0fa2d457bc14c29d9322906495ccbe2d 498 SUPERFAMILY SSF52540 3 475 1.48E-77 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1033 0fa2d457bc14c29d9322906495ccbe2d 498 Pfam PF13245 AAA domain 14 197 2.5E-25 T 13-10-2018 TOPB45_0002 aced2b61587b43194d468dcf78634fba 461 SUPERFAMILY SSF56176 7 219 7.94E-66 T 13-10-2018 IPR036318 FAD-binding, type PCMH-like superfamily GO:0050660 TOPB45_0002 aced2b61587b43194d468dcf78634fba 461 Gene3D G3DSA:1.10.45.10 419 456 6.6E-10 T 13-10-2018 IPR016171 Vanillyl-alcohol oxidase, C-terminal subdomain 2 TOPB45_0002 aced2b61587b43194d468dcf78634fba 461 Gene3D G3DSA:3.30.465.40 6 238 1.0E-72 T 13-10-2018 TOPB45_0002 aced2b61587b43194d468dcf78634fba 461 Pfam PF01565 FAD binding domain 43 182 3.9E-42 T 13-10-2018 IPR006094 FAD linked oxidase, N-terminal GO:0016491|GO:0050660|GO:0055114 TOPB45_0002 aced2b61587b43194d468dcf78634fba 461 SUPERFAMILY SSF55103 193 460 1.62E-48 T 13-10-2018 IPR016164 FAD-linked oxidase-like, C-terminal GO:0003824|GO:0050660 TOPB45_0002 aced2b61587b43194d468dcf78634fba 461 Gene3D G3DSA:3.30.70.2740 340 418 9.3E-14 T 13-10-2018 TOPB45_0002 aced2b61587b43194d468dcf78634fba 461 Pfam PF02913 FAD linked oxidases, C-terminal domain 233 456 8.0E-47 T 13-10-2018 IPR004113 FAD-linked oxidase, C-terminal GO:0003824|GO:0050660 TOPB45_1300 a9d1c0d867db826aa9f213e402a0c0a0 545 Gene3D G3DSA:3.40.50.12780 10 435 6.9E-88 T 13-10-2018 TOPB45_1300 a9d1c0d867db826aa9f213e402a0c0a0 545 SUPERFAMILY SSF56801 19 536 8.63E-124 T 13-10-2018 TOPB45_1300 a9d1c0d867db826aa9f213e402a0c0a0 545 Pfam PF00501 AMP-binding enzyme 24 439 2.1E-75 T 13-10-2018 IPR000873 AMP-dependent synthetase/ligase GO:0003824 TOPB45_1300 a9d1c0d867db826aa9f213e402a0c0a0 545 Gene3D G3DSA:3.30.300.310 436 539 3.5E-32 T 13-10-2018 TOPB45_1300 a9d1c0d867db826aa9f213e402a0c0a0 545 Pfam PF13193 AMP-binding enzyme C-terminal domain 449 524 2.2E-21 T 13-10-2018 IPR025110 AMP-binding enzyme, C-terminal domain TOPB45_1418 2fccd62fede0c6fd5eb1f8ff802df685 119 Pfam PF02579 Dinitrogenase iron-molybdenum cofactor 9 99 2.3E-23 T 13-10-2018 IPR003731 Dinitrogenase iron-molybdenum cofactor biosynthesis TOPB45_1418 2fccd62fede0c6fd5eb1f8ff802df685 119 SUPERFAMILY SSF53146 1 119 1.19E-35 T 13-10-2018 IPR036105 Dinitrogenase iron-molybdenum cofactor biosynthesis superfamily TOPB45_1418 2fccd62fede0c6fd5eb1f8ff802df685 119 Gene3D G3DSA:3.30.420.130 1 101 5.1E-34 T 13-10-2018 IPR036105 Dinitrogenase iron-molybdenum cofactor biosynthesis superfamily TOPB45_1589 1e613cffc4b345ab116f956daae9405f 560 Gene3D G3DSA:3.40.50.880 295 559 2.6E-105 T 13-10-2018 IPR029062 Class I glutamine amidotransferase-like TOPB45_1589 1e613cffc4b345ab116f956daae9405f 560 SUPERFAMILY SSF52317 298 550 3.3E-86 T 13-10-2018 IPR029062 Class I glutamine amidotransferase-like TOPB45_1589 1e613cffc4b345ab116f956daae9405f 560 Pfam PF06418 CTP synthase N-terminus 13 276 7.3E-125 T 13-10-2018 IPR017456 CTP synthase, N-terminal GO:0003883|GO:0006221 KEGG: 00240+6.3.4.2|MetaCyc: PWY-7176|MetaCyc: PWY-7177|MetaCyc: PWY-7185|Reactome: R-HSA-499943 TOPB45_1589 1e613cffc4b345ab116f956daae9405f 560 TIGRFAM TIGR00337 PyrG: CTP synthase 12 546 7.2E-250 T 13-10-2018 IPR004468 CTP synthase GO:0003883|GO:0006221 KEGG: 00240+6.3.4.2|MetaCyc: PWY-7176|MetaCyc: PWY-7177|MetaCyc: PWY-7185|Reactome: R-HSA-499943 TOPB45_1589 1e613cffc4b345ab116f956daae9405f 560 Gene3D G3DSA:3.40.50.300 3 294 2.8E-128 T 13-10-2018 TOPB45_1589 1e613cffc4b345ab116f956daae9405f 560 SUPERFAMILY SSF52540 12 280 3.32E-122 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1589 1e613cffc4b345ab116f956daae9405f 560 Hamap MF_01227 CTP synthase [pyrG]. 12 552 51.819 T 13-10-2018 IPR004468 CTP synthase GO:0003883|GO:0006221 KEGG: 00240+6.3.4.2|MetaCyc: PWY-7176|MetaCyc: PWY-7177|MetaCyc: PWY-7185|Reactome: R-HSA-499943 TOPB45_1589 1e613cffc4b345ab116f956daae9405f 560 Pfam PF00117 Glutamine amidotransferase class-I 311 546 7.9E-57 T 13-10-2018 IPR017926 Glutamine amidotransferase TOPB45_1455 d659f7f6eb0b989a4e9236c092b262c5 402 Gene3D G3DSA:3.40.50.620 5 222 9.8E-77 T 13-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TOPB45_1455 d659f7f6eb0b989a4e9236c092b262c5 402 SUPERFAMILY SSF52374 7 322 1.44E-94 T 13-10-2018 TOPB45_1455 d659f7f6eb0b989a4e9236c092b262c5 402 PRINTS PR01040 Tyrosyl-tRNA synthetase signature 166 181 2.6E-25 T 13-10-2018 IPR002307 Tyrosine-tRNA ligase GO:0000166|GO:0004831|GO:0005524|GO:0005737|GO:0006437 KEGG: 00970+6.1.1.1 TOPB45_1455 d659f7f6eb0b989a4e9236c092b262c5 402 PRINTS PR01040 Tyrosyl-tRNA synthetase signature 51 73 2.6E-25 T 13-10-2018 IPR002307 Tyrosine-tRNA ligase GO:0000166|GO:0004831|GO:0005524|GO:0005737|GO:0006437 KEGG: 00970+6.1.1.1 TOPB45_1455 d659f7f6eb0b989a4e9236c092b262c5 402 PRINTS PR01040 Tyrosyl-tRNA synthetase signature 216 228 2.6E-25 T 13-10-2018 IPR002307 Tyrosine-tRNA ligase GO:0000166|GO:0004831|GO:0005524|GO:0005737|GO:0006437 KEGG: 00970+6.1.1.1 TOPB45_1455 d659f7f6eb0b989a4e9236c092b262c5 402 PRINTS PR01040 Tyrosyl-tRNA synthetase signature 183 205 2.6E-25 T 13-10-2018 IPR002307 Tyrosine-tRNA ligase GO:0000166|GO:0004831|GO:0005524|GO:0005737|GO:0006437 KEGG: 00970+6.1.1.1 TOPB45_1455 d659f7f6eb0b989a4e9236c092b262c5 402 SUPERFAMILY SSF55174 304 400 9.25E-13 T 13-10-2018 TOPB45_1455 d659f7f6eb0b989a4e9236c092b262c5 402 ProSitePatterns PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 47 57 - T 13-10-2018 IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site GO:0000166|GO:0004812|GO:0005524|GO:0006418 TOPB45_1455 d659f7f6eb0b989a4e9236c092b262c5 402 TIGRFAM TIGR00234 tyrS: tyrosine--tRNA ligase 6 401 5.2E-123 T 13-10-2018 IPR002307 Tyrosine-tRNA ligase GO:0000166|GO:0004831|GO:0005524|GO:0005737|GO:0006437 KEGG: 00970+6.1.1.1 TOPB45_1455 d659f7f6eb0b989a4e9236c092b262c5 402 Gene3D G3DSA:3.10.290.10 329 401 7.5E-14 T 13-10-2018 IPR036986 RNA-binding S4 domain superfamily GO:0003723 TOPB45_1455 d659f7f6eb0b989a4e9236c092b262c5 402 Hamap MF_02007 Tyrosine--tRNA ligase [tyrS]. 3 401 46.482 T 13-10-2018 IPR024108 Tyrosine-tRNA ligase, bacterial-type, type 2 GO:0004831 KEGG: 00970+6.1.1.1 TOPB45_1455 d659f7f6eb0b989a4e9236c092b262c5 402 Pfam PF00579 tRNA synthetases class I (W and Y) 35 322 6.9E-82 T 13-10-2018 IPR002305 Aminoacyl-tRNA synthetase, class Ic GO:0000166|GO:0004812|GO:0005524|GO:0006418 TOPB45_1455 d659f7f6eb0b989a4e9236c092b262c5 402 Gene3D G3DSA:1.10.240.10 227 328 9.8E-25 T 13-10-2018 TOPB45_1252 a63215d26b413d08579a591250f2b8f3 267 Pfam PF02535 ZIP Zinc transporter 126 264 1.4E-20 T 13-10-2018 IPR003689 Zinc/iron permease GO:0016020|GO:0030001|GO:0046873|GO:0055085 TOPB45_1302 d7826c9a5ad2538e43290200d741a16e 420 Gene3D G3DSA:3.20.20.70 50 371 4.1E-46 T 13-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 TOPB45_1302 d7826c9a5ad2538e43290200d741a16e 420 SUPERFAMILY SSF51569 61 411 5.13E-54 T 13-10-2018 TOPB45_1302 d7826c9a5ad2538e43290200d741a16e 420 Pfam PF01116 Fructose-bisphosphate aldolase class-II 62 333 3.2E-11 T 13-10-2018 IPR000771 Fructose-bisphosphate aldolase, class-II GO:0005975|GO:0008270|GO:0016832 TOPB45_1305 16519da315e347db0bbaa3faaab8f59a 448 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 249 265 4.8E-24 T 13-10-2018 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 TOPB45_1305 16519da315e347db0bbaa3faaab8f59a 448 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 210 227 4.8E-24 T 13-10-2018 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 TOPB45_1305 16519da315e347db0bbaa3faaab8f59a 448 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 306 318 4.8E-24 T 13-10-2018 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 TOPB45_1305 16519da315e347db0bbaa3faaab8f59a 448 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 90 109 4.8E-24 T 13-10-2018 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 TOPB45_1305 16519da315e347db0bbaa3faaab8f59a 448 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 177 193 4.8E-24 T 13-10-2018 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 TOPB45_1305 16519da315e347db0bbaa3faaab8f59a 448 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 228 246 4.8E-24 T 13-10-2018 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 TOPB45_1305 16519da315e347db0bbaa3faaab8f59a 448 PIRSF PIRSF000534 11 448 1.3E-172 T 13-10-2018 IPR012004 Pyrophosphate-dependent phosphofructokinase TP0108-type GO:0003872|GO:0005524|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385 TOPB45_1305 16519da315e347db0bbaa3faaab8f59a 448 SUPERFAMILY SSF53784 49 445 3.92E-127 T 13-10-2018 IPR035966 Phosphofructokinase superfamily GO:0003872|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 TOPB45_1305 16519da315e347db0bbaa3faaab8f59a 448 Pfam PF00365 Phosphofructokinase 87 394 1.6E-66 T 13-10-2018 IPR000023 Phosphofructokinase domain GO:0003872|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 TOPB45_1305 16519da315e347db0bbaa3faaab8f59a 448 Gene3D G3DSA:3.40.50.450 82 275 5.0E-61 T 13-10-2018 TOPB45_1305 16519da315e347db0bbaa3faaab8f59a 448 Hamap MF_01981 ATP-dependent 6-phosphofructokinase [pfkA]. 8 446 51.714 T 13-10-2018 IPR012004 Pyrophosphate-dependent phosphofructokinase TP0108-type GO:0003872|GO:0005524|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385 TOPB45_0194 8e6ee1fda6dc43bdd82d29d5e8adde36 322 Gene3D G3DSA:3.30.70.270 153 317 8.2E-36 T 13-10-2018 TOPB45_0194 8e6ee1fda6dc43bdd82d29d5e8adde36 322 Pfam PF00990 Diguanylate cyclase, GGDEF domain 157 307 3.6E-31 T 13-10-2018 IPR000160 GGDEF domain TOPB45_0194 8e6ee1fda6dc43bdd82d29d5e8adde36 322 SUPERFAMILY SSF52172 21 149 3.79E-10 T 13-10-2018 IPR011006 CheY-like superfamily TOPB45_0194 8e6ee1fda6dc43bdd82d29d5e8adde36 322 SMART SM00267 143 312 3.9E-31 T 13-10-2018 IPR000160 GGDEF domain TOPB45_0194 8e6ee1fda6dc43bdd82d29d5e8adde36 322 Gene3D G3DSA:3.40.50.2300 14 152 2.0E-9 T 13-10-2018 TOPB45_0194 8e6ee1fda6dc43bdd82d29d5e8adde36 322 SUPERFAMILY SSF55073 160 311 2.9E-32 T 13-10-2018 IPR029787 Nucleotide cyclase TOPB45_0194 8e6ee1fda6dc43bdd82d29d5e8adde36 322 TIGRFAM TIGR00254 GGDEF: diguanylate cyclase (GGDEF) domain 156 311 7.1E-32 T 13-10-2018 IPR000160 GGDEF domain TOPB45_0428 d716a3395efeccdced21d6d7513fd22a 799 Gene3D G3DSA:3.10.350.10 163 236 6.4E-18 T 13-10-2018 IPR036779 LysM domain superfamily TOPB45_0428 d716a3395efeccdced21d6d7513fd22a 799 Gene3D G3DSA:3.10.350.10 29 103 1.5E-18 T 13-10-2018 IPR036779 LysM domain superfamily TOPB45_0428 d716a3395efeccdced21d6d7513fd22a 799 SUPERFAMILY SSF54106 112 155 7.85E-12 T 13-10-2018 TOPB45_0428 d716a3395efeccdced21d6d7513fd22a 799 Gene3D G3DSA:3.10.350.10 110 162 1.9E-19 T 13-10-2018 IPR036779 LysM domain superfamily TOPB45_0428 d716a3395efeccdced21d6d7513fd22a 799 SUPERFAMILY SSF54106 42 86 2.09E-11 T 13-10-2018 TOPB45_0428 d716a3395efeccdced21d6d7513fd22a 799 SMART SM00257 113 156 2.8E-18 T 13-10-2018 IPR018392 LysM domain TOPB45_0428 d716a3395efeccdced21d6d7513fd22a 799 SMART SM00257 44 87 8.9E-16 T 13-10-2018 IPR018392 LysM domain TOPB45_0428 d716a3395efeccdced21d6d7513fd22a 799 SMART SM00257 178 221 8.9E-16 T 13-10-2018 IPR018392 LysM domain TOPB45_0428 d716a3395efeccdced21d6d7513fd22a 799 Gene3D G3DSA:1.25.40.10 260 417 4.9E-11 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_0428 d716a3395efeccdced21d6d7513fd22a 799 Pfam PF11741 AMIN domain 438 516 3.4E-9 T 13-10-2018 IPR021731 AMIN domain TOPB45_0428 d716a3395efeccdced21d6d7513fd22a 799 Gene3D G3DSA:3.40.630.40 566 793 9.0E-73 T 13-10-2018 TOPB45_0428 d716a3395efeccdced21d6d7513fd22a 799 Gene3D G3DSA:2.60.40.3500 418 534 1.2E-22 T 13-10-2018 TOPB45_0428 d716a3395efeccdced21d6d7513fd22a 799 SUPERFAMILY SSF53187 570 785 4.08E-55 T 13-10-2018 TOPB45_0428 d716a3395efeccdced21d6d7513fd22a 799 Pfam PF01476 LysM domain 45 86 4.1E-13 T 13-10-2018 IPR018392 LysM domain TOPB45_0428 d716a3395efeccdced21d6d7513fd22a 799 Pfam PF01476 LysM domain 179 220 4.1E-13 T 13-10-2018 IPR018392 LysM domain TOPB45_0428 d716a3395efeccdced21d6d7513fd22a 799 Pfam PF01476 LysM domain 114 155 6.7E-15 T 13-10-2018 IPR018392 LysM domain TOPB45_0428 d716a3395efeccdced21d6d7513fd22a 799 SMART SM00646 631 782 2.2E-42 T 13-10-2018 IPR002508 N-acetylmuramoyl-L-alanine amidase, catalytic domain GO:0008745|GO:0009253 TOPB45_0428 d716a3395efeccdced21d6d7513fd22a 799 Pfam PF01520 N-acetylmuramoyl-L-alanine amidase 571 782 3.3E-53 T 13-10-2018 IPR002508 N-acetylmuramoyl-L-alanine amidase, catalytic domain GO:0008745|GO:0009253 TOPB45_0428 d716a3395efeccdced21d6d7513fd22a 799 SUPERFAMILY SSF54106 176 220 2.09E-11 T 13-10-2018 TOPB45_1618 e1ca8694529721bb3f4102577139710c 66 Pfam PF03884 DNA gyrase inhibitor YacG 7 53 1.1E-20 T 13-10-2018 IPR005584 DNA gyrase inhibitor YacG GO:0008270 TOPB45_1618 e1ca8694529721bb3f4102577139710c 66 Hamap MF_00649 DNA gyrase inhibitor YacG [yacG]. 3 59 15.888 T 13-10-2018 IPR005584 DNA gyrase inhibitor YacG GO:0008270 TOPB45_1618 e1ca8694529721bb3f4102577139710c 66 SUPERFAMILY SSF57716 4 55 4.28E-17 T 13-10-2018 TOPB45_1618 e1ca8694529721bb3f4102577139710c 66 Gene3D G3DSA:3.30.50.10 1 58 6.3E-21 T 13-10-2018 IPR013088 Zinc finger, NHR/GATA-type GO:0006355|GO:0008270 Reactome: R-HSA-383280 TOPB45_1118 6c3e99862633200840dcdcb3f185fd80 291 Pfam PF01867 CRISPR associated protein Cas1 7 269 7.2E-58 T 13-10-2018 IPR002729 CRISPR-associated protein Cas1 GO:0003676|GO:0004519|GO:0043571|GO:0046872|GO:0051607 TOPB45_1118 6c3e99862633200840dcdcb3f185fd80 291 Gene3D G3DSA:1.20.120.920 84 287 1.7E-42 T 13-10-2018 TOPB45_1118 6c3e99862633200840dcdcb3f185fd80 291 Hamap MF_01470 CRISPR-associated endonuclease Cas1 [cas1]. 2 281 19.896 T 13-10-2018 IPR002729 CRISPR-associated protein Cas1 GO:0003676|GO:0004519|GO:0043571|GO:0046872|GO:0051607 TOPB45_1118 6c3e99862633200840dcdcb3f185fd80 291 TIGRFAM TIGR00287 cas1: CRISPR-associated endonuclease Cas1 7 275 1.2E-56 T 13-10-2018 IPR002729 CRISPR-associated protein Cas1 GO:0003676|GO:0004519|GO:0043571|GO:0046872|GO:0051607 TOPB45_1118 6c3e99862633200840dcdcb3f185fd80 291 Gene3D G3DSA:3.100.10.20 1 80 4.3E-17 T 13-10-2018 TOPB45_0069 d44f52a760fad41ddcbb354db2f31379 92 ProSitePatterns PS00045 Bacterial histone-like DNA-binding proteins signature. 46 65 - T 13-10-2018 IPR020816 Histone-like DNA-binding protein, conserved site GO:0003677 TOPB45_0069 d44f52a760fad41ddcbb354db2f31379 92 Gene3D G3DSA:4.10.520.10 1 92 1.3E-35 T 13-10-2018 IPR010992 Integration host factor (IHF)-like DNA-binding domain superfamily GO:0003677 TOPB45_0069 d44f52a760fad41ddcbb354db2f31379 92 SUPERFAMILY SSF47729 1 90 1.77E-31 T 13-10-2018 IPR010992 Integration host factor (IHF)-like DNA-binding domain superfamily GO:0003677 TOPB45_0069 d44f52a760fad41ddcbb354db2f31379 92 SMART SM00411 1 90 1.5E-37 T 13-10-2018 IPR000119 Histone-like DNA-binding protein GO:0003677 TOPB45_0069 d44f52a760fad41ddcbb354db2f31379 92 PRINTS PR01727 Prokaryotic integration host factor signature 40 55 9.3E-17 T 13-10-2018 IPR000119 Histone-like DNA-binding protein GO:0003677 TOPB45_0069 d44f52a760fad41ddcbb354db2f31379 92 PRINTS PR01727 Prokaryotic integration host factor signature 58 71 9.3E-17 T 13-10-2018 IPR000119 Histone-like DNA-binding protein GO:0003677 TOPB45_0069 d44f52a760fad41ddcbb354db2f31379 92 PRINTS PR01727 Prokaryotic integration host factor signature 74 88 9.3E-17 T 13-10-2018 IPR000119 Histone-like DNA-binding protein GO:0003677 TOPB45_0069 d44f52a760fad41ddcbb354db2f31379 92 Pfam PF00216 Bacterial DNA-binding protein 1 89 4.7E-34 T 13-10-2018 IPR000119 Histone-like DNA-binding protein GO:0003677 TOPB45_1395 971075f1830626bf06b20ce6446a3388 516 Pfam PF13671 AAA domain 339 473 1.0E-20 T 13-10-2018 TOPB45_1395 971075f1830626bf06b20ce6446a3388 516 Gene3D G3DSA:3.40.50.300 336 516 9.2E-27 T 13-10-2018 TOPB45_1395 971075f1830626bf06b20ce6446a3388 516 SUPERFAMILY SSF56112 22 289 2.62E-12 T 13-10-2018 IPR011009 Protein kinase-like domain superfamily TOPB45_1395 971075f1830626bf06b20ce6446a3388 516 SUPERFAMILY SSF52540 337 515 1.47E-21 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0167 655f90e4d61608b8b865aabdb41ebad4 239 PIRSF PIRSF002155 1 227 3.8E-84 T 13-10-2018 IPR002143 Ribosomal protein L1 GO:0003723|GO:0003735|GO:0006412|GO:0015934 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0167 655f90e4d61608b8b865aabdb41ebad4 239 ProSitePatterns PS01199 Ribosomal protein L1 signature. 121 139 - T 13-10-2018 IPR023673 Ribosomal protein L1, conserved site Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0167 655f90e4d61608b8b865aabdb41ebad4 239 Gene3D G3DSA:3.30.190.20 21 225 8.2E-88 T 13-10-2018 TOPB45_0167 655f90e4d61608b8b865aabdb41ebad4 239 Hamap MF_01318_B 50S ribosomal protein L1 [rplA]. 2 229 44.749 T 13-10-2018 IPR005878 Ribosomal protein L1, bacterial-type GO:0003723|GO:0003735|GO:0006412|GO:0015934 TOPB45_0167 655f90e4d61608b8b865aabdb41ebad4 239 SUPERFAMILY SSF56808 6 227 8.89E-89 T 13-10-2018 IPR023674 Ribosomal protein L1-like TOPB45_0167 655f90e4d61608b8b865aabdb41ebad4 239 Pfam PF00687 Ribosomal protein L1p/L10e family 33 220 1.2E-57 T 13-10-2018 IPR028364 Ribosomal protein L1/ribosomal biogenesis protein TOPB45_0167 655f90e4d61608b8b865aabdb41ebad4 239 Gene3D G3DSA:3.40.50.790 68 159 8.2E-88 T 13-10-2018 IPR016095 Ribosomal protein L1, 3-layer alpha/beta-sandwich TOPB45_0167 655f90e4d61608b8b865aabdb41ebad4 239 TIGRFAM TIGR01169 rplA_bact: ribosomal protein uL1 4 227 7.5E-105 T 13-10-2018 IPR005878 Ribosomal protein L1, bacterial-type GO:0003723|GO:0003735|GO:0006412|GO:0015934 TOPB45_0887 d1f69c2e07f6824fa0da859c9aea829a 653 Gene3D G3DSA:1.10.569.10 290 480 4.2E-14 T 13-10-2018 IPR013984 Aldehyde ferredoxin oxidoreductase, domain 2 TOPB45_0887 d1f69c2e07f6824fa0da859c9aea829a 653 SUPERFAMILY SSF48310 255 608 1.15E-45 T 13-10-2018 IPR036021 Aldehyde ferredoxin oxidoreductase-like, C-terminal GO:0009055|GO:0016491|GO:0016625|GO:0051536|GO:0055114 TOPB45_0887 d1f69c2e07f6824fa0da859c9aea829a 653 Pfam PF01314 Aldehyde ferredoxin oxidoreductase, domains 2 & 3 291 410 2.4E-14 T 13-10-2018 IPR001203 Aldehyde ferredoxin oxidoreductase, C-terminal GO:0009055|GO:0016491|GO:0016625|GO:0051536|GO:0055114 TOPB45_0887 d1f69c2e07f6824fa0da859c9aea829a 653 SMART SM00790 4 230 2.4E-16 T 13-10-2018 IPR013983 Aldehyde ferredoxin oxidoreductase, N-terminal GO:0016491|GO:0016625|GO:0051536|GO:0055114 TOPB45_0887 d1f69c2e07f6824fa0da859c9aea829a 653 SUPERFAMILY SSF56228 4 231 6.67E-33 T 13-10-2018 IPR036503 Aldehyde ferredoxin oxidoreductase, N-terminal domain superfamily TOPB45_0887 d1f69c2e07f6824fa0da859c9aea829a 653 Pfam PF02730 Aldehyde ferredoxin oxidoreductase, N-terminal domain 5 229 1.2E-35 T 13-10-2018 IPR013983 Aldehyde ferredoxin oxidoreductase, N-terminal GO:0016491|GO:0016625|GO:0051536|GO:0055114 TOPB45_0887 d1f69c2e07f6824fa0da859c9aea829a 653 Gene3D G3DSA:3.60.9.10 2 233 1.9E-19 T 13-10-2018 IPR036503 Aldehyde ferredoxin oxidoreductase, N-terminal domain superfamily TOPB45_1135 c9cf35c503157c0e47961fd10c1cbeb4 239 Pfam PF00005 ABC transporter 20 162 3.4E-30 T 13-10-2018 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TOPB45_1135 c9cf35c503157c0e47961fd10c1cbeb4 239 SUPERFAMILY SSF52540 3 227 3.99E-57 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1135 c9cf35c503157c0e47961fd10c1cbeb4 239 SMART SM00382 29 219 1.8E-12 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_1135 c9cf35c503157c0e47961fd10c1cbeb4 239 ProSitePatterns PS00211 ABC transporters family signature. 134 148 - T 13-10-2018 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TOPB45_1135 c9cf35c503157c0e47961fd10c1cbeb4 239 Gene3D G3DSA:3.40.50.300 3 238 1.5E-60 T 13-10-2018 TOPB45_0083 a044b12352b8412285dc7f9d0b4726de 63 Hamap MF_00340 50S ribosomal protein L32 [rpmF]. 1 55 20.102 T 13-10-2018 IPR002677 Ribosomal protein L32p GO:0003735|GO:0006412|GO:0015934 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0083 a044b12352b8412285dc7f9d0b4726de 63 SUPERFAMILY SSF57829 1 55 3.42E-22 T 13-10-2018 IPR011332 Zinc-binding ribosomal protein GO:0006412 TOPB45_0083 a044b12352b8412285dc7f9d0b4726de 63 Pfam PF01783 Ribosomal L32p protein family 2 57 3.9E-26 T 13-10-2018 IPR002677 Ribosomal protein L32p GO:0003735|GO:0006412|GO:0015934 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0083 a044b12352b8412285dc7f9d0b4726de 63 TIGRFAM TIGR01031 rpmF_bact: ribosomal protein bL32 2 56 1.8E-25 T 13-10-2018 IPR002677 Ribosomal protein L32p GO:0003735|GO:0006412|GO:0015934 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_1119 7cbbc28bfa0fa9d68a5099d6ed2df123 81 SUPERFAMILY SSF143430 2 68 5.62E-10 T 13-10-2018 TOPB45_1119 7cbbc28bfa0fa9d68a5099d6ed2df123 81 TIGRFAM TIGR01573 cas2: CRISPR-associated endonuclease Cas2 2 47 1.0E-7 T 13-10-2018 IPR021127 CRISPR-associated endonuclease Cas2 GO:0004521|GO:0043571 TOPB45_1119 7cbbc28bfa0fa9d68a5099d6ed2df123 81 Gene3D G3DSA:3.30.70.240 1 79 2.2E-7 T 13-10-2018 TOPB45_1119 7cbbc28bfa0fa9d68a5099d6ed2df123 81 Pfam PF09827 CRISPR associated protein Cas2 2 46 2.7E-8 T 13-10-2018 IPR019199 Virulence-associated protein D / CRISPR associated protein Cas2 TOPB45_0993 19cc0587b8379b1cbf982ee92024844d 111 Hamap MF_00274 Nucleoid-associated protein YbaB [ybaB]. 5 99 21.348 T 13-10-2018 IPR004401 Nucleoid-associated protein YbaB/EbfC family TOPB45_0993 19cc0587b8379b1cbf982ee92024844d 111 PIRSF PIRSF004555 4 109 2.8E-38 T 13-10-2018 IPR004401 Nucleoid-associated protein YbaB/EbfC family TOPB45_0993 19cc0587b8379b1cbf982ee92024844d 111 Pfam PF02575 YbaB/EbfC DNA-binding family 12 100 7.5E-32 T 13-10-2018 IPR004401 Nucleoid-associated protein YbaB/EbfC family TOPB45_0993 19cc0587b8379b1cbf982ee92024844d 111 TIGRFAM TIGR00103 DNA_YbaB_EbfC: DNA-binding protein, YbaB/EbfC family 7 105 2.8E-26 T 13-10-2018 IPR004401 Nucleoid-associated protein YbaB/EbfC family TOPB45_0993 19cc0587b8379b1cbf982ee92024844d 111 SUPERFAMILY SSF82607 11 105 1.44E-29 T 13-10-2018 IPR036894 Nucleoid-associated protein YbaB-like domain superfamily TOPB45_0993 19cc0587b8379b1cbf982ee92024844d 111 Gene3D G3DSA:3.30.1310.10 4 109 7.2E-36 T 13-10-2018 IPR036894 Nucleoid-associated protein YbaB-like domain superfamily TOPB45_1509 592b1c0f59a4a45f23574f92a3d2c798 784 SMART SM00487 249 448 8.2E-19 T 13-10-2018 IPR014001 Helicase superfamily 1/2, ATP-binding domain TOPB45_1509 592b1c0f59a4a45f23574f92a3d2c798 784 Gene3D G3DSA:1.10.8.630 2 108 2.8E-22 T 13-10-2018 TOPB45_1509 592b1c0f59a4a45f23574f92a3d2c798 784 Hamap MF_00983 Probable primosomal protein N' [priA]. 6 783 23.672 T 13-10-2018 IPR005259 Primosomal protein N' GO:0003677|GO:0004003|GO:0006260|GO:0032508 TOPB45_1509 592b1c0f59a4a45f23574f92a3d2c798 784 Gene3D G3DSA:3.40.50.300 243 436 1.0E-63 T 13-10-2018 TOPB45_1509 592b1c0f59a4a45f23574f92a3d2c798 784 SMART SM00490 545 642 6.4E-6 T 13-10-2018 IPR001650 Helicase, C-terminal TOPB45_1509 592b1c0f59a4a45f23574f92a3d2c798 784 SUPERFAMILY SSF52540 192 438 5.54E-42 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1509 592b1c0f59a4a45f23574f92a3d2c798 784 SUPERFAMILY SSF52540 512 679 1.49E-20 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1509 592b1c0f59a4a45f23574f92a3d2c798 784 TIGRFAM TIGR00595 priA: primosomal protein N' 277 780 4.1E-166 T 13-10-2018 IPR005259 Primosomal protein N' GO:0003677|GO:0004003|GO:0006260|GO:0032508 TOPB45_1509 592b1c0f59a4a45f23574f92a3d2c798 784 Pfam PF00270 DEAD/DEAH box helicase 274 417 3.4E-11 T 13-10-2018 IPR011545 DEAD/DEAH box helicase domain GO:0003676|GO:0005524 TOPB45_1509 592b1c0f59a4a45f23574f92a3d2c798 784 Pfam PF00271 Helicase conserved C-terminal domain 547 641 1.6E-4 T 13-10-2018 IPR001650 Helicase, C-terminal TOPB45_1056 1c62fb6cd20be466fc01f40d3add5361 260 Gene3D G3DSA:3.90.320.10 87 184 1.6E-6 T 13-10-2018 IPR011604 Exonuclease, phage-type/RecB, C-terminal TOPB45_1056 1c62fb6cd20be466fc01f40d3add5361 260 Pfam PF12705 PD-(D/E)XK nuclease superfamily 101 246 3.7E-11 T 13-10-2018 IPR038726 PD-(D/E)XK endonuclease-like domain, AddAB-type TOPB45_1056 1c62fb6cd20be466fc01f40d3add5361 260 SUPERFAMILY SSF52980 103 174 7.51E-5 T 13-10-2018 IPR011335 Restriction endonuclease type II-like Reactome: R-HSA-6783310 TOPB45_1098 905e4f034a16775406c2496366f6fd94 261 Pfam PF12705 PD-(D/E)XK nuclease superfamily 75 245 6.9E-11 T 13-10-2018 IPR038726 PD-(D/E)XK endonuclease-like domain, AddAB-type TOPB45_1098 905e4f034a16775406c2496366f6fd94 261 SUPERFAMILY SSF52980 75 173 5.9E-5 T 13-10-2018 IPR011335 Restriction endonuclease type II-like Reactome: R-HSA-6783310 TOPB45_0933 bd877604f05ec6c929e7fa241cee6b61 266 SUPERFAMILY SSF53850 42 262 1.25E-46 T 13-10-2018 TOPB45_0933 bd877604f05ec6c929e7fa241cee6b61 266 PIRSF PIRSF004846 1 265 5.9E-44 T 13-10-2018 IPR005950 Molybdate ABC transporter, substrate-binding protein GO:0015689 TOPB45_0933 bd877604f05ec6c929e7fa241cee6b61 266 Pfam PF13531 Bacterial extracellular solute-binding protein 44 262 6.5E-36 T 13-10-2018 TOPB45_0933 bd877604f05ec6c929e7fa241cee6b61 266 Gene3D G3DSA:3.40.190.10 120 227 1.3E-46 T 13-10-2018 TOPB45_0933 bd877604f05ec6c929e7fa241cee6b61 266 TIGRFAM TIGR01256 modA: molybdate ABC transporter, periplasmic molybdate-binding protein 49 260 6.6E-35 T 13-10-2018 IPR005950 Molybdate ABC transporter, substrate-binding protein GO:0015689 TOPB45_0933 bd877604f05ec6c929e7fa241cee6b61 266 Gene3D G3DSA:3.40.190.10 47 260 1.3E-46 T 13-10-2018 TOPB45_0915 ba169154a748e4aceb3fdc23ee8af1cf 254 Hamap MF_00304 Thiamine thiazole synthase [thi4]. 1 253 40.136 T 13-10-2018 IPR022828 Thiazole biosynthetic enzyme, prokaryotic TOPB45_0915 ba169154a748e4aceb3fdc23ee8af1cf 254 Pfam PF01946 Thi4 family 7 234 9.9E-70 T 13-10-2018 TOPB45_0915 ba169154a748e4aceb3fdc23ee8af1cf 254 TIGRFAM TIGR00292 TIGR00292: thiazole biosynthesis enzyme 2 252 4.6E-93 T 13-10-2018 IPR002922 Thiazole biosynthetic enzyme Thi4 family TOPB45_0915 ba169154a748e4aceb3fdc23ee8af1cf 254 SUPERFAMILY SSF51905 2 251 2.43E-42 T 13-10-2018 IPR036188 FAD/NAD(P)-binding domain superfamily TOPB45_0915 ba169154a748e4aceb3fdc23ee8af1cf 254 PRINTS PR00419 Adrenodoxin reductase family signature 24 46 8.2E-6 T 13-10-2018 TOPB45_0915 ba169154a748e4aceb3fdc23ee8af1cf 254 PRINTS PR00419 Adrenodoxin reductase family signature 47 60 8.2E-6 T 13-10-2018 TOPB45_0915 ba169154a748e4aceb3fdc23ee8af1cf 254 Gene3D G3DSA:3.50.50.60 1 254 1.2E-87 T 13-10-2018 IPR036188 FAD/NAD(P)-binding domain superfamily TOPB45_0336 823d248e361dafecc971fc12baf9fd82 434 Pfam PF01943 Polysaccharide biosynthesis protein 25 295 1.7E-63 T 13-10-2018 IPR002797 Polysaccharide biosynthesis protein GO:0016020 TOPB45_0336 823d248e361dafecc971fc12baf9fd82 434 Pfam PF14667 Polysaccharide biosynthesis C-terminal domain 346 427 5.6E-8 T 13-10-2018 IPR029303 Polysaccharide biosynthesis protein, C-terminal domain TOPB45_1535 ce73b311ef3d84882dc7c5faec87e82c 286 Pfam PF02749 Quinolinate phosphoribosyl transferase, N-terminal domain 20 108 1.7E-24 T 13-10-2018 IPR022412 Quinolinate phosphoribosyl transferase, N-terminal GO:0016763 Reactome: R-HSA-196807 TOPB45_1535 ce73b311ef3d84882dc7c5faec87e82c 286 SUPERFAMILY SSF51690 110 280 4.32E-57 T 13-10-2018 IPR036068 Nicotinate phosphoribosyltransferase-like, C-terminal GO:0004514|GO:0009435 KEGG: 00760+6.3.4.21|MetaCyc: PWY-5381 TOPB45_1535 ce73b311ef3d84882dc7c5faec87e82c 286 Pfam PF01729 Quinolinate phosphoribosyl transferase, C-terminal domain 110 279 5.0E-61 T 13-10-2018 IPR002638 Quinolinate phosphoribosyl transferase, C-terminal GO:0004514|GO:0009435 Reactome: R-HSA-196807 TOPB45_1535 ce73b311ef3d84882dc7c5faec87e82c 286 SUPERFAMILY SSF54675 4 109 1.96E-30 T 13-10-2018 TOPB45_1535 ce73b311ef3d84882dc7c5faec87e82c 286 Gene3D G3DSA:3.20.20.70 124 270 1.7E-103 T 13-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 TOPB45_1535 ce73b311ef3d84882dc7c5faec87e82c 286 PIRSF PIRSF006250 1 283 2.8E-92 T 13-10-2018 IPR027277 Nicotinate-nucleotide pyrophosphorylase/Putative pyrophosphorylase ModD Reactome: R-HSA-196807 TOPB45_1535 ce73b311ef3d84882dc7c5faec87e82c 286 TIGRFAM TIGR00078 nadC: nicotinate-nucleotide diphosphorylase (carboxylating) 11 280 1.6E-94 T 13-10-2018 IPR004393 Nicotinate-nucleotide pyrophosphorylase GO:0004514|GO:0019363 KEGG: 00760+2.4.2.19|MetaCyc: PWY-5316|MetaCyc: PWY-5653|MetaCyc: PWY-7342|Reactome: R-HSA-196807 TOPB45_1535 ce73b311ef3d84882dc7c5faec87e82c 286 Gene3D G3DSA:3.90.1170.20 14 278 1.7E-103 T 13-10-2018 IPR037128 Quinolinate phosphoribosyl transferase, N-terminal domain superfamily GO:0016763 Reactome: R-HSA-196807 TOPB45_1498 f4f23422ebeae50a9260475bea4b92bb 369 Gene3D G3DSA:3.40.710.10 21 302 2.7E-82 T 13-10-2018 TOPB45_1498 f4f23422ebeae50a9260475bea4b92bb 369 Pfam PF00768 D-alanyl-D-alanine carboxypeptidase 36 260 1.3E-56 T 13-10-2018 IPR001967 Peptidase S11, D-alanyl-D-alanine carboxypeptidase A, N-terminal GO:0006508|GO:0009002 TOPB45_1498 f4f23422ebeae50a9260475bea4b92bb 369 PRINTS PR00725 D-Ala-D-Ala carboxypeptidase 1 (S11) family signature 65 76 1.1E-11 T 13-10-2018 IPR018044 Peptidase S11, D-alanyl-D-alanine carboxypeptidase A GO:0006508|GO:0009002 TOPB45_1498 f4f23422ebeae50a9260475bea4b92bb 369 PRINTS PR00725 D-Ala-D-Ala carboxypeptidase 1 (S11) family signature 113 130 1.1E-11 T 13-10-2018 IPR018044 Peptidase S11, D-alanyl-D-alanine carboxypeptidase A GO:0006508|GO:0009002 TOPB45_1498 f4f23422ebeae50a9260475bea4b92bb 369 PRINTS PR00725 D-Ala-D-Ala carboxypeptidase 1 (S11) family signature 140 153 1.1E-11 T 13-10-2018 IPR018044 Peptidase S11, D-alanyl-D-alanine carboxypeptidase A GO:0006508|GO:0009002 TOPB45_1498 f4f23422ebeae50a9260475bea4b92bb 369 SUPERFAMILY SSF56601 4 276 1.55E-62 T 13-10-2018 IPR012338 Beta-lactamase/transpeptidase-like TOPB45_0709 d351bf8ecb25712f7550d868ece1633c 431 Pfam PF01746 tRNA (Guanine-1)-methyltransferase 23 219 2.2E-58 T 13-10-2018 IPR016009 tRNA methyltransferase TRMD/TRM10-type domain MetaCyc: PWY-6829|MetaCyc: PWY-7285|MetaCyc: PWY-7286 TOPB45_0709 d351bf8ecb25712f7550d868ece1633c 431 Gene3D G3DSA:3.40.1280.10 244 429 1.7E-71 T 13-10-2018 IPR029026 tRNA (guanine-N1-)-methyltransferase, N-terminal TOPB45_0709 d351bf8ecb25712f7550d868ece1633c 431 Gene3D G3DSA:3.40.1280.10 1 171 4.1E-72 T 13-10-2018 IPR029026 tRNA (guanine-N1-)-methyltransferase, N-terminal TOPB45_0709 d351bf8ecb25712f7550d868ece1633c 431 Gene3D G3DSA:1.10.1270.20 172 243 2.7E-25 T 13-10-2018 IPR023148 tRNA (guanine-N1-)-methyltransferase, C-terminal GO:0008033|GO:0052906 MetaCyc: PWY-6829|MetaCyc: PWY-7285|MetaCyc: PWY-7286 TOPB45_0709 d351bf8ecb25712f7550d868ece1633c 431 Hamap MF_00605 tRNA (guanine-N(1)-)-methyltransferase [trmD]. 1 287 97.67 T 13-10-2018 IPR002649 tRNA (guanine-N1-)-methyltransferase, bacteria GO:0008033|GO:0052906 MetaCyc: PWY-6829|MetaCyc: PWY-7285|MetaCyc: PWY-7286 TOPB45_0709 d351bf8ecb25712f7550d868ece1633c 431 Pfam PF09936 SAM-dependent RNA methyltransferase 245 424 4.6E-71 T 13-10-2018 IPR019230 RNA methyltransferase domain TOPB45_0709 d351bf8ecb25712f7550d868ece1633c 431 TIGRFAM TIGR00088 trmD: tRNA (guanine(37)-N(1))-methyltransferase 1 234 1.7E-89 T 13-10-2018 IPR002649 tRNA (guanine-N1-)-methyltransferase, bacteria GO:0008033|GO:0052906 MetaCyc: PWY-6829|MetaCyc: PWY-7285|MetaCyc: PWY-7286 TOPB45_0709 d351bf8ecb25712f7550d868ece1633c 431 SUPERFAMILY SSF75217 1 242 7.1E-94 T 13-10-2018 IPR029028 Alpha/beta knot methyltransferases TOPB45_0432 b69c6a356c37293fb549e41f2ee05f4b 370 SUPERFAMILY SSF53633 15 266 1.09E-66 T 13-10-2018 IPR036393 Acetylglutamate kinase-like superfamily TOPB45_0432 b69c6a356c37293fb549e41f2ee05f4b 370 PRINTS PR00474 Glutamate 5-kinase family signature 219 239 1.9E-53 T 13-10-2018 IPR001057 Glutamate/acetylglutamate kinase Reactome: R-HSA-70614 TOPB45_0432 b69c6a356c37293fb549e41f2ee05f4b 370 PRINTS PR00474 Glutamate 5-kinase family signature 126 147 1.9E-53 T 13-10-2018 IPR001057 Glutamate/acetylglutamate kinase Reactome: R-HSA-70614 TOPB45_0432 b69c6a356c37293fb549e41f2ee05f4b 370 PRINTS PR00474 Glutamate 5-kinase family signature 52 66 1.9E-53 T 13-10-2018 IPR001057 Glutamate/acetylglutamate kinase Reactome: R-HSA-70614 TOPB45_0432 b69c6a356c37293fb549e41f2ee05f4b 370 PRINTS PR00474 Glutamate 5-kinase family signature 158 185 1.9E-53 T 13-10-2018 IPR001057 Glutamate/acetylglutamate kinase Reactome: R-HSA-70614 TOPB45_0432 b69c6a356c37293fb549e41f2ee05f4b 370 PRINTS PR00474 Glutamate 5-kinase family signature 86 114 1.9E-53 T 13-10-2018 IPR001057 Glutamate/acetylglutamate kinase Reactome: R-HSA-70614 TOPB45_0432 b69c6a356c37293fb549e41f2ee05f4b 370 PIRSF PIRSF000729 10 370 2.6E-126 T 13-10-2018 IPR011529 Glutamate 5-kinase GO:0004349|GO:0005737|GO:0006561 KEGG: 00330+2.7.2.11|KEGG: 00332+2.7.2.11|MetaCyc: PWY-3341|MetaCyc: PWY-6922 TOPB45_0432 b69c6a356c37293fb549e41f2ee05f4b 370 Gene3D G3DSA:2.30.130.10 276 369 2.1E-24 T 13-10-2018 IPR036974 PUA domain superfamily GO:0003723 TOPB45_0432 b69c6a356c37293fb549e41f2ee05f4b 370 Pfam PF01472 PUA domain 287 349 3.4E-18 T 13-10-2018 IPR002478 PUA domain GO:0003723 TOPB45_0432 b69c6a356c37293fb549e41f2ee05f4b 370 SMART SM00359 287 365 2.8E-19 T 13-10-2018 IPR002478 PUA domain GO:0003723 TOPB45_0432 b69c6a356c37293fb549e41f2ee05f4b 370 Pfam PF00696 Amino acid kinase family 15 244 1.2E-39 T 13-10-2018 IPR001048 Aspartate/glutamate/uridylate kinase Reactome: R-HSA-70614 TOPB45_0432 b69c6a356c37293fb549e41f2ee05f4b 370 TIGRFAM TIGR01027 proB: glutamate 5-kinase 15 367 2.4E-125 T 13-10-2018 IPR005715 Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase GO:0005737|GO:0006561 KEGG: 00330+2.7.2.11|KEGG: 00332+2.7.2.11|MetaCyc: PWY-3341|MetaCyc: PWY-6922|Reactome: R-HSA-70614 TOPB45_0432 b69c6a356c37293fb549e41f2ee05f4b 370 ProSitePatterns PS00902 Glutamate 5-kinase signature. 217 234 - T 13-10-2018 IPR019797 Glutamate 5-kinase, conserved site GO:0004349|GO:0006561 KEGG: 00330+2.7.2.11|KEGG: 00332+2.7.2.11|MetaCyc: PWY-3341|MetaCyc: PWY-6922|Reactome: R-HSA-70614 TOPB45_0432 b69c6a356c37293fb549e41f2ee05f4b 370 Gene3D G3DSA:3.40.1160.10 4 275 3.6E-90 T 13-10-2018 IPR036393 Acetylglutamate kinase-like superfamily TOPB45_0432 b69c6a356c37293fb549e41f2ee05f4b 370 Hamap MF_00456 Glutamate 5-kinase [proB]. 15 270 35.8 T 13-10-2018 IPR005715 Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase GO:0005737|GO:0006561 KEGG: 00330+2.7.2.11|KEGG: 00332+2.7.2.11|MetaCyc: PWY-3341|MetaCyc: PWY-6922|Reactome: R-HSA-70614 TOPB45_0432 b69c6a356c37293fb549e41f2ee05f4b 370 SUPERFAMILY SSF88697 287 368 4.2E-18 T 13-10-2018 IPR015947 PUA-like superfamily TOPB45_1022 e90ab974ded1c49a6e2e3a58990bb70d 312 SUPERFAMILY SSF52440 7 100 3.93E-25 T 13-10-2018 IPR016185 Pre-ATP-grasp domain superfamily TOPB45_1022 e90ab974ded1c49a6e2e3a58990bb70d 312 Gene3D G3DSA:3.30.1490.20 116 184 7.0E-69 T 13-10-2018 IPR013815 ATP-grasp fold, subdomain 1 GO:0005524 TOPB45_1022 e90ab974ded1c49a6e2e3a58990bb70d 312 Gene3D G3DSA:3.30.470.20 90 303 7.0E-69 T 13-10-2018 TOPB45_1022 e90ab974ded1c49a6e2e3a58990bb70d 312 ProSitePatterns PS00844 D-alanine--D-alanine ligase signature 2. 250 277 - T 13-10-2018 IPR000291 D-alanine--D-alanine ligase/VANA/B/C, conserved site KEGG: 00473+6.3.2.4|KEGG: 00550+6.3.2.4|MetaCyc: PWY-6386|MetaCyc: PWY-6387|MetaCyc: PWY-7953 TOPB45_1022 e90ab974ded1c49a6e2e3a58990bb70d 312 Pfam PF01820 D-ala D-ala ligase N-terminus 8 90 4.2E-16 T 13-10-2018 IPR011127 D-alanine--D-alanine ligase, N-terminal domain KEGG: 00473+6.3.2.4|KEGG: 00550+6.3.2.4|MetaCyc: PWY-6386|MetaCyc: PWY-6387|MetaCyc: PWY-7953 TOPB45_1022 e90ab974ded1c49a6e2e3a58990bb70d 312 Hamap MF_00047 D-alanine--D-alanine ligase [ddl]. 7 307 34.122 T 13-10-2018 IPR005905 D-alanine--D-alanine ligase GO:0005737|GO:0008716 KEGG: 00473+6.3.2.4|KEGG: 00550+6.3.2.4|MetaCyc: PWY-6386|MetaCyc: PWY-6387|MetaCyc: PWY-7953 TOPB45_1022 e90ab974ded1c49a6e2e3a58990bb70d 312 SMART SM01209 100 281 0.0056 T 13-10-2018 TOPB45_1022 e90ab974ded1c49a6e2e3a58990bb70d 312 PIRSF PIRSF039102 5 51 1.7E-7 T 13-10-2018 IPR005905 D-alanine--D-alanine ligase GO:0005737|GO:0008716 KEGG: 00473+6.3.2.4|KEGG: 00550+6.3.2.4|MetaCyc: PWY-6386|MetaCyc: PWY-6387|MetaCyc: PWY-7953 TOPB45_1022 e90ab974ded1c49a6e2e3a58990bb70d 312 PIRSF PIRSF039102 47 312 3.5E-83 T 13-10-2018 IPR005905 D-alanine--D-alanine ligase GO:0005737|GO:0008716 KEGG: 00473+6.3.2.4|KEGG: 00550+6.3.2.4|MetaCyc: PWY-6386|MetaCyc: PWY-6387|MetaCyc: PWY-7953 TOPB45_1022 e90ab974ded1c49a6e2e3a58990bb70d 312 ProSitePatterns PS00843 D-alanine--D-alanine ligase signature 1. 68 79 - T 13-10-2018 IPR000291 D-alanine--D-alanine ligase/VANA/B/C, conserved site KEGG: 00473+6.3.2.4|KEGG: 00550+6.3.2.4|MetaCyc: PWY-6386|MetaCyc: PWY-6387|MetaCyc: PWY-7953 TOPB45_1022 e90ab974ded1c49a6e2e3a58990bb70d 312 SUPERFAMILY SSF56059 102 303 2.46E-49 T 13-10-2018 TOPB45_1022 e90ab974ded1c49a6e2e3a58990bb70d 312 Pfam PF07478 D-ala D-ala ligase C-terminus 110 304 1.2E-49 T 13-10-2018 IPR011095 D-alanine--D-alanine ligase, C-terminal GO:0008716 KEGG: 00473+6.3.2.4|KEGG: 00550+6.3.2.4|MetaCyc: PWY-6386|MetaCyc: PWY-6387|MetaCyc: PWY-7953 TOPB45_1022 e90ab974ded1c49a6e2e3a58990bb70d 312 TIGRFAM TIGR01205 D_ala_D_alaTIGR: D-alanine--D-alanine ligase 8 306 1.9E-89 T 13-10-2018 IPR005905 D-alanine--D-alanine ligase GO:0005737|GO:0008716 KEGG: 00473+6.3.2.4|KEGG: 00550+6.3.2.4|MetaCyc: PWY-6386|MetaCyc: PWY-6387|MetaCyc: PWY-7953 TOPB45_1022 e90ab974ded1c49a6e2e3a58990bb70d 312 Gene3D G3DSA:3.40.50.20 2 89 1.1E-23 T 13-10-2018 TOPB45_0981 544105f11a1b86d121180e35cb80795d 121 ProSitePatterns PS01015 Ribosomal protein L19 signature. 87 102 - T 13-10-2018 IPR018257 Ribosomal protein L19, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0981 544105f11a1b86d121180e35cb80795d 121 SUPERFAMILY SSF50104 2 117 4.21E-47 T 13-10-2018 IPR008991 Translation protein SH3-like domain superfamily TOPB45_0981 544105f11a1b86d121180e35cb80795d 121 PIRSF PIRSF002191 1 121 2.3E-51 T 13-10-2018 IPR001857 Ribosomal protein L19 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0981 544105f11a1b86d121180e35cb80795d 121 Hamap MF_00402 50S ribosomal protein L19 [rplS]. 2 115 31.836 T 13-10-2018 IPR001857 Ribosomal protein L19 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0981 544105f11a1b86d121180e35cb80795d 121 PRINTS PR00061 Ribosomal protein L19 signature 35 64 3.4E-40 T 13-10-2018 IPR001857 Ribosomal protein L19 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0981 544105f11a1b86d121180e35cb80795d 121 PRINTS PR00061 Ribosomal protein L19 signature 89 114 3.4E-40 T 13-10-2018 IPR001857 Ribosomal protein L19 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0981 544105f11a1b86d121180e35cb80795d 121 PRINTS PR00061 Ribosomal protein L19 signature 4 33 3.4E-40 T 13-10-2018 IPR001857 Ribosomal protein L19 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0981 544105f11a1b86d121180e35cb80795d 121 Gene3D G3DSA:2.30.30.790 6 118 7.4E-17 T 13-10-2018 IPR038657 Ribosomal protein L19 superfamily Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0981 544105f11a1b86d121180e35cb80795d 121 Pfam PF01245 Ribosomal protein L19 4 114 5.8E-50 T 13-10-2018 IPR001857 Ribosomal protein L19 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0981 544105f11a1b86d121180e35cb80795d 121 TIGRFAM TIGR01024 rplS_bact: ribosomal protein bL19 4 114 3.4E-49 T 13-10-2018 IPR001857 Ribosomal protein L19 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0196 c6b1287f50b22f601eaf64ee1450be87 328 Pfam PF00571 CBS domain 201 257 1.2E-5 T 13-10-2018 IPR000644 CBS domain TOPB45_0196 c6b1287f50b22f601eaf64ee1450be87 328 Pfam PF00571 CBS domain 268 320 7.1E-9 T 13-10-2018 IPR000644 CBS domain TOPB45_0196 c6b1287f50b22f601eaf64ee1450be87 328 PIRSF PIRSF004692 1 324 6.7E-132 T 13-10-2018 IPR004800 Phosphosugar isomerase, KdsD/KpsF-type GO:0005975|GO:0016853 TOPB45_0196 c6b1287f50b22f601eaf64ee1450be87 328 SMART SM00116 210 258 0.0021 T 13-10-2018 IPR000644 CBS domain TOPB45_0196 c6b1287f50b22f601eaf64ee1450be87 328 SMART SM00116 275 323 0.023 T 13-10-2018 IPR000644 CBS domain TOPB45_0196 c6b1287f50b22f601eaf64ee1450be87 328 Gene3D G3DSA:3.10.580.10 197 320 6.3E-42 T 13-10-2018 TOPB45_0196 c6b1287f50b22f601eaf64ee1450be87 328 Gene3D G3DSA:3.40.50.10490 2 196 2.5E-67 T 13-10-2018 TOPB45_0196 c6b1287f50b22f601eaf64ee1450be87 328 Pfam PF01380 SIS domain 44 171 7.4E-30 T 13-10-2018 IPR001347 Sugar isomerase (SIS) GO:0097367|GO:1901135 TOPB45_0196 c6b1287f50b22f601eaf64ee1450be87 328 TIGRFAM TIGR00393 kpsF: sugar isomerase, KpsF/GutQ family 45 314 8.0E-102 T 13-10-2018 IPR004800 Phosphosugar isomerase, KdsD/KpsF-type GO:0005975|GO:0016853 TOPB45_0196 c6b1287f50b22f601eaf64ee1450be87 328 SUPERFAMILY SSF53697 9 319 8.45E-64 T 13-10-2018 TOPB45_0284 ebca0dba3726fd4cec97f0f42a1bc4ab 134 SUPERFAMILY SSF54637 4 128 2.3E-35 T 13-10-2018 IPR029069 HotDog domain superfamily TOPB45_0284 ebca0dba3726fd4cec97f0f42a1bc4ab 134 TIGRFAM TIGR00051 TIGR00051: acyl-CoA thioester hydrolase, YbgC/YbaW family 7 121 9.8E-27 T 13-10-2018 IPR006684 Acyl-CoA thioester hydrolase YbgC/YbaW family GO:0016787 TOPB45_0284 ebca0dba3726fd4cec97f0f42a1bc4ab 134 Gene3D G3DSA:3.10.129.10 2 131 2.6E-35 T 13-10-2018 TOPB45_0284 ebca0dba3726fd4cec97f0f42a1bc4ab 134 Pfam PF03061 Thioesterase superfamily 19 99 2.5E-12 T 13-10-2018 IPR006683 Thioesterase domain Reactome: R-HSA-77289 TOPB45_0284 ebca0dba3726fd4cec97f0f42a1bc4ab 134 PIRSF PIRSF003230 1 134 1.4E-41 T 13-10-2018 IPR006684 Acyl-CoA thioester hydrolase YbgC/YbaW family GO:0016787 TOPB45_1257 8e6694cc8c2e6f9d2f8d2a0cc4661cd7 445 SUPERFAMILY SSF55931 108 443 2.06E-120 T 13-10-2018 IPR014746 Glutamine synthetase/guanido kinase, catalytic domain GO:0003824 TOPB45_1257 8e6694cc8c2e6f9d2f8d2a0cc4661cd7 445 Gene3D G3DSA:3.10.20.70 7 110 2.2E-43 T 13-10-2018 IPR036651 Glutamine synthetase, N-terminal domain superfamily GO:0004356|GO:0006542|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 TOPB45_1257 8e6694cc8c2e6f9d2f8d2a0cc4661cd7 445 Pfam PF00120 Glutamine synthetase, catalytic domain 109 441 1.2E-128 T 13-10-2018 IPR008146 Glutamine synthetase, catalytic domain GO:0004356|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 TOPB45_1257 8e6694cc8c2e6f9d2f8d2a0cc4661cd7 445 SMART SM01230 108 355 1.3E-133 T 13-10-2018 IPR008146 Glutamine synthetase, catalytic domain GO:0004356|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 TOPB45_1257 8e6694cc8c2e6f9d2f8d2a0cc4661cd7 445 Pfam PF03951 Glutamine synthetase, beta-Grasp domain 20 102 1.3E-33 T 13-10-2018 IPR008147 Glutamine synthetase, beta-Grasp domain GO:0004356|GO:0006542|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964|Reactome: R-HSA-210455|Reactome: R-HSA-70614 TOPB45_1257 8e6694cc8c2e6f9d2f8d2a0cc4661cd7 445 ProSitePatterns PS00181 Glutamine synthetase putative ATP-binding region signature. 232 247 - T 13-10-2018 IPR027303 Glutamine synthetase, glycine-rich site KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964|Reactome: R-HSA-210455|Reactome: R-HSA-70614 TOPB45_1257 8e6694cc8c2e6f9d2f8d2a0cc4661cd7 445 Gene3D G3DSA:3.30.590.10 111 443 1.7E-124 T 13-10-2018 TOPB45_1257 8e6694cc8c2e6f9d2f8d2a0cc4661cd7 445 SUPERFAMILY SSF54368 10 107 1.57E-34 T 13-10-2018 IPR036651 Glutamine synthetase, N-terminal domain superfamily GO:0004356|GO:0006542|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 TOPB45_0638 1ffce4a747a39e712c9f42682b023cc7 349 ProSitePatterns PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 154 181 - T 13-10-2018 IPR029752 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 TOPB45_0638 1ffce4a747a39e712c9f42682b023cc7 349 ProSitePatterns PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 231 247 - T 13-10-2018 IPR029753 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site TOPB45_0638 1ffce4a747a39e712c9f42682b023cc7 349 Pfam PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 24 336 7.4E-25 T 13-10-2018 IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain GO:0016616|GO:0051287|GO:0055114 TOPB45_0638 1ffce4a747a39e712c9f42682b023cc7 349 SUPERFAMILY SSF51735 110 315 1.06E-46 T 13-10-2018 IPR036291 NAD(P)-binding domain superfamily TOPB45_0638 1ffce4a747a39e712c9f42682b023cc7 349 Pfam PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 117 314 2.1E-51 T 13-10-2018 IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain GO:0051287|GO:0055114 TOPB45_0638 1ffce4a747a39e712c9f42682b023cc7 349 Gene3D G3DSA:3.40.50.720 4 336 3.4E-106 T 13-10-2018 TOPB45_0638 1ffce4a747a39e712c9f42682b023cc7 349 Gene3D G3DSA:3.40.50.720 109 314 3.4E-106 T 13-10-2018 TOPB45_0638 1ffce4a747a39e712c9f42682b023cc7 349 SUPERFAMILY SSF52283 21 135 5.74E-25 T 13-10-2018 TOPB45_1254 e2733e7211e4f06eea71921f2bdd646b 91 Pfam PF08546 Ketopantoate reductase PanE/ApbA C terminal 49 82 1.4E-4 T 13-10-2018 IPR013752 Ketopantoate reductase, C-terminal domain TOPB45_1254 e2733e7211e4f06eea71921f2bdd646b 91 Gene3D G3DSA:3.40.50.720 1 80 1.4E-8 T 13-10-2018 TOPB45_1254 e2733e7211e4f06eea71921f2bdd646b 91 SUPERFAMILY SSF51735 1 33 6.39E-6 T 13-10-2018 IPR036291 NAD(P)-binding domain superfamily TOPB45_1254 e2733e7211e4f06eea71921f2bdd646b 91 Pfam PF02558 Ketopantoate reductase PanE/ApbA 3 53 3.6E-6 T 13-10-2018 IPR013332 Ketopantoate reductase, N-terminal domain TOPB45_0620 ab3ee1c3bc85699876f82c1a4eefa11e 387 PIRSF PIRSF000497 1 384 2.9E-171 T 13-10-2018 IPR002133 S-adenosylmethionine synthetase GO:0004478|GO:0005524|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: R-HSA-156581 TOPB45_0620 ab3ee1c3bc85699876f82c1a4eefa11e 387 Pfam PF00438 S-adenosylmethionine synthetase, N-terminal domain 5 103 4.9E-43 T 13-10-2018 IPR022628 S-adenosylmethionine synthetase, N-terminal GO:0004478|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: R-HSA-156581 TOPB45_0620 ab3ee1c3bc85699876f82c1a4eefa11e 387 Gene3D G3DSA:3.30.300.10 7 233 4.9E-170 T 13-10-2018 TOPB45_0620 ab3ee1c3bc85699876f82c1a4eefa11e 387 TIGRFAM TIGR01034 metK: methionine adenosyltransferase 7 382 6.5E-180 T 13-10-2018 IPR002133 S-adenosylmethionine synthetase GO:0004478|GO:0005524|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: R-HSA-156581 TOPB45_0620 ab3ee1c3bc85699876f82c1a4eefa11e 387 SUPERFAMILY SSF55973 233 383 3.14E-64 T 13-10-2018 IPR022636 S-adenosylmethionine synthetase superfamily GO:0004478|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: R-HSA-156581 TOPB45_0620 ab3ee1c3bc85699876f82c1a4eefa11e 387 Pfam PF02773 S-adenosylmethionine synthetase, C-terminal domain 233 372 8.5E-63 T 13-10-2018 IPR022630 S-adenosylmethionine synthetase, C-terminal GO:0004478|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: R-HSA-156581 TOPB45_0620 ab3ee1c3bc85699876f82c1a4eefa11e 387 SUPERFAMILY SSF55973 111 232 4.71E-50 T 13-10-2018 IPR022636 S-adenosylmethionine synthetase superfamily GO:0004478|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: R-HSA-156581 TOPB45_0620 ab3ee1c3bc85699876f82c1a4eefa11e 387 ProSitePatterns PS00377 S-adenosylmethionine synthase signature 2. 259 267 - T 13-10-2018 IPR022631 S-adenosylmethionine synthetase, conserved site GO:0004478|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: R-HSA-156581 TOPB45_0620 ab3ee1c3bc85699876f82c1a4eefa11e 387 ProSitePatterns PS00376 S-adenosylmethionine synthase signature 1. 116 126 - T 13-10-2018 IPR022631 S-adenosylmethionine synthetase, conserved site GO:0004478|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: R-HSA-156581 TOPB45_0620 ab3ee1c3bc85699876f82c1a4eefa11e 387 Pfam PF02772 S-adenosylmethionine synthetase, central domain 114 231 3.9E-46 T 13-10-2018 IPR022629 S-adenosylmethionine synthetase, central domain GO:0004478|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: R-HSA-156581 TOPB45_0620 ab3ee1c3bc85699876f82c1a4eefa11e 387 Gene3D G3DSA:3.30.300.10 104 374 4.9E-170 T 13-10-2018 TOPB45_0620 ab3ee1c3bc85699876f82c1a4eefa11e 387 Hamap MF_00086 S-adenosylmethionine synthase [metK]. 4 383 56.136 T 13-10-2018 IPR002133 S-adenosylmethionine synthetase GO:0004478|GO:0005524|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: R-HSA-156581 TOPB45_0620 ab3ee1c3bc85699876f82c1a4eefa11e 387 SUPERFAMILY SSF55973 5 112 7.85E-47 T 13-10-2018 IPR022636 S-adenosylmethionine synthetase superfamily GO:0004478|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: R-HSA-156581 TOPB45_0620 ab3ee1c3bc85699876f82c1a4eefa11e 387 Gene3D G3DSA:3.30.300.10 13 270 4.9E-170 T 13-10-2018 TOPB45_0209 1ba5a0211a1f7b26617939aa92d16f19 545 TIGRFAM TIGR00973 leuA_bact: 2-isopropylmalate synthase 4 524 1.8E-182 T 13-10-2018 IPR005671 2-isopropylmalate synthase, bacterial-type GO:0003852|GO:0009098 KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871 TOPB45_0209 1ba5a0211a1f7b26617939aa92d16f19 545 ProSitePatterns PS00815 Alpha-isopropylmalate and homocitrate synthases signature 1. 12 28 - T 13-10-2018 IPR002034 Alpha-isopropylmalate/homocitrate synthase, conserved site GO:0019752|GO:0046912 KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871 TOPB45_0209 1ba5a0211a1f7b26617939aa92d16f19 545 Gene3D G3DSA:3.20.20.70 2 290 1.3E-106 T 13-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 TOPB45_0209 1ba5a0211a1f7b26617939aa92d16f19 545 SUPERFAMILY SSF110921 421 526 9.15E-16 T 13-10-2018 IPR036230 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain superfamily KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871 TOPB45_0209 1ba5a0211a1f7b26617939aa92d16f19 545 Pfam PF08502 LeuA allosteric (dimerisation) domain 385 526 1.2E-18 T 13-10-2018 IPR013709 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain GO:0003852|GO:0009098 KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871 TOPB45_0209 1ba5a0211a1f7b26617939aa92d16f19 545 SUPERFAMILY SSF51569 2 305 6.59E-95 T 13-10-2018 TOPB45_0209 1ba5a0211a1f7b26617939aa92d16f19 545 Gene3D G3DSA:3.30.160.270 409 527 5.6E-7 T 13-10-2018 TOPB45_0209 1ba5a0211a1f7b26617939aa92d16f19 545 Pfam PF00682 HMGL-like 5 287 1.9E-91 T 13-10-2018 IPR000891 Pyruvate carboxyltransferase GO:0003824 TOPB45_0209 1ba5a0211a1f7b26617939aa92d16f19 545 Gene3D G3DSA:1.10.238.260 295 408 1.1E-30 T 13-10-2018 TOPB45_0209 1ba5a0211a1f7b26617939aa92d16f19 545 ProSitePatterns PS00816 Alpha-isopropylmalate and homocitrate synthases signature 2. 207 220 - T 13-10-2018 IPR002034 Alpha-isopropylmalate/homocitrate synthase, conserved site GO:0019752|GO:0046912 KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871 TOPB45_0209 1ba5a0211a1f7b26617939aa92d16f19 545 SMART SM00917 384 527 1.0E-13 T 13-10-2018 IPR013709 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain GO:0003852|GO:0009098 KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871 TOPB45_0840 12040ad638a620b5fbf0551850c6faf1 312 SUPERFAMILY SSF144083 248 309 2.48E-13 T 13-10-2018 TOPB45_0840 12040ad638a620b5fbf0551850c6faf1 312 SUPERFAMILY SSF143865 17 247 9.15E-49 T 13-10-2018 TOPB45_0840 12040ad638a620b5fbf0551850c6faf1 312 Gene3D G3DSA:1.20.58.340 256 312 2.1E-8 T 13-10-2018 TOPB45_0840 12040ad638a620b5fbf0551850c6faf1 312 Pfam PF01544 CorA-like Mg2+ transporter protein 22 308 6.6E-54 T 13-10-2018 IPR002523 Mg2+ transporter protein, CorA-like/Zinc transport protein ZntB GO:0016020|GO:0030001|GO:0046873|GO:0055085 TOPB45_0840 12040ad638a620b5fbf0551850c6faf1 312 Gene3D G3DSA:3.30.460.20 13 126 8.0E-23 T 13-10-2018 TOPB45_0840 12040ad638a620b5fbf0551850c6faf1 312 Gene3D G3DSA:1.20.58.340 129 254 9.2E-25 T 13-10-2018 TOPB45_1613 2753ba2776a6b189a3893d64343e64ac 435 Gene3D G3DSA:3.30.70.2130 108 255 8.0E-122 T 13-10-2018 TOPB45_1613 2753ba2776a6b189a3893d64343e64ac 435 Gene3D G3DSA:3.40.720.10 34 423 8.0E-122 T 13-10-2018 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824 TOPB45_1613 2753ba2776a6b189a3893d64343e64ac 435 TIGRFAM TIGR02535 hyp_Hser_kinase: proposed homoserine kinase 31 430 1.1E-174 T 13-10-2018 IPR023665 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, prokaryotes GO:0046537 KEGG: 00010+5.4.2.12|KEGG: 00260+5.4.2.12|KEGG: 00680+5.4.2.12|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TOPB45_1613 2753ba2776a6b189a3893d64343e64ac 435 TIGRFAM TIGR00306 apgM: phosphoglycerate mutase (2,3-diphosphoglycerate-independent), archaeal form 34 424 1.1E-111 T 13-10-2018 IPR004456 2,3-bisphosphoglycerate-independent phosphoglycerate mutase GO:0003824|GO:0046537 KEGG: 00010+5.4.2.12|KEGG: 00260+5.4.2.12|KEGG: 00680+5.4.2.12|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TOPB45_1613 2753ba2776a6b189a3893d64343e64ac 435 SUPERFAMILY SSF53649 31 393 3.92E-28 T 13-10-2018 IPR017850 Alkaline-phosphatase-like, core domain superfamily GO:0003824 TOPB45_1613 2753ba2776a6b189a3893d64343e64ac 435 PIRSF PIRSF006392 28 434 2.2E-127 T 13-10-2018 IPR004456 2,3-bisphosphoglycerate-independent phosphoglycerate mutase GO:0003824|GO:0046537 KEGG: 00010+5.4.2.12|KEGG: 00260+5.4.2.12|KEGG: 00680+5.4.2.12|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TOPB45_1613 2753ba2776a6b189a3893d64343e64ac 435 Pfam PF01676 Metalloenzyme superfamily 31 412 1.5E-36 T 13-10-2018 IPR006124 Metalloenzyme GO:0003824|GO:0046872 TOPB45_1613 2753ba2776a6b189a3893d64343e64ac 435 Pfam PF10143 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 67 233 9.7E-52 T 13-10-2018 IPR004456 2,3-bisphosphoglycerate-independent phosphoglycerate mutase GO:0003824|GO:0046537 KEGG: 00010+5.4.2.12|KEGG: 00260+5.4.2.12|KEGG: 00680+5.4.2.12|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TOPB45_0614 fa9b9a3f58c43ac0e096768b241247b6 824 SMART SM00490 628 713 1.1E-22 T 13-10-2018 IPR001650 Helicase, C-terminal TOPB45_0614 fa9b9a3f58c43ac0e096768b241247b6 824 SUPERFAMILY SSF52540 343 576 1.68E-58 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0614 fa9b9a3f58c43ac0e096768b241247b6 824 SUPERFAMILY SSF50249 129 301 4.97E-45 T 13-10-2018 IPR012340 Nucleic acid-binding, OB-fold TOPB45_0614 fa9b9a3f58c43ac0e096768b241247b6 824 Gene3D G3DSA:2.40.50.140 169 266 1.4E-17 T 13-10-2018 TOPB45_0614 fa9b9a3f58c43ac0e096768b241247b6 824 SMART SM00487 391 583 4.1E-33 T 13-10-2018 IPR014001 Helicase superfamily 1/2, ATP-binding domain TOPB45_0614 fa9b9a3f58c43ac0e096768b241247b6 824 Pfam PF00270 DEAD/DEAH box helicase 396 555 2.9E-17 T 13-10-2018 IPR011545 DEAD/DEAH box helicase domain GO:0003676|GO:0005524 TOPB45_0614 fa9b9a3f58c43ac0e096768b241247b6 824 Pfam PF00271 Helicase conserved C-terminal domain 600 712 1.6E-19 T 13-10-2018 IPR001650 Helicase, C-terminal TOPB45_0614 fa9b9a3f58c43ac0e096768b241247b6 824 Gene3D G3DSA:1.10.150.20 125 167 1.2E-5 T 13-10-2018 TOPB45_0614 fa9b9a3f58c43ac0e096768b241247b6 824 TIGRFAM TIGR00643 recG: ATP-dependent DNA helicase RecG 151 790 5.3E-230 T 13-10-2018 IPR004609 ATP-dependent DNA helicase RecG GO:0004003|GO:0006281|GO:0006310 TOPB45_0614 fa9b9a3f58c43ac0e096768b241247b6 824 Gene3D G3DSA:3.40.50.300 581 755 3.7E-58 T 13-10-2018 TOPB45_0614 fa9b9a3f58c43ac0e096768b241247b6 824 Gene3D G3DSA:3.40.50.300 376 580 4.6E-87 T 13-10-2018 TOPB45_0614 fa9b9a3f58c43ac0e096768b241247b6 824 SUPERFAMILY SSF52540 576 780 4.87E-41 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0614 fa9b9a3f58c43ac0e096768b241247b6 824 Pfam PF17191 RecG wedge domain 132 297 1.8E-32 T 13-10-2018 IPR033454 RecG, wedge domain TOPB45_1045 219d316c693f55361080fe7af689e69c 294 TIGRFAM TIGR00081 purC: phosphoribosylaminoimidazolesuccinocarboxamide synthase 12 291 3.3E-78 T 13-10-2018 IPR001636 Phosphoribosylaminoimidazole-succinocarboxamide synthase GO:0004639|GO:0006164 KEGG: 00230+6.3.2.6|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234 TOPB45_1045 219d316c693f55361080fe7af689e69c 294 Gene3D G3DSA:3.30.470.20 106 248 6.8E-65 T 13-10-2018 TOPB45_1045 219d316c693f55361080fe7af689e69c 294 Pfam PF01259 SAICAR synthetase 16 267 4.3E-103 T 13-10-2018 IPR028923 SAICAR synthetase/ADE2, N-terminal KEGG: 00230+6.3.2.6|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234|Reactome: R-HSA-73817 TOPB45_1045 219d316c693f55361080fe7af689e69c 294 Hamap MF_00137 Phosphoribosylaminoimidazole-succinocarboxamide synthase [purC]. 13 291 26.807 T 13-10-2018 IPR028923 SAICAR synthetase/ADE2, N-terminal KEGG: 00230+6.3.2.6|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234|Reactome: R-HSA-73817 TOPB45_1045 219d316c693f55361080fe7af689e69c 294 SUPERFAMILY SSF56104 5 293 1.14E-105 T 13-10-2018 TOPB45_1045 219d316c693f55361080fe7af689e69c 294 ProSitePatterns PS01057 SAICAR synthetase signature 1. 107 121 - T 13-10-2018 IPR018236 SAICAR synthetase, conserved site GO:0004639|GO:0006164 KEGG: 00230+6.3.2.6|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234|Reactome: R-HSA-73817 TOPB45_1045 219d316c693f55361080fe7af689e69c 294 Gene3D G3DSA:3.30.200.20 3 105 3.3E-32 T 13-10-2018 TOPB45_1045 219d316c693f55361080fe7af689e69c 294 ProSitePatterns PS01058 SAICAR synthetase signature 2. 205 213 - T 13-10-2018 IPR018236 SAICAR synthetase, conserved site GO:0004639|GO:0006164 KEGG: 00230+6.3.2.6|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234|Reactome: R-HSA-73817 TOPB45_1462 991fa4ecff8750eba7897a432d3fb9b2 530 Gene3D G3DSA:3.60.110.10 235 501 5.4E-17 T 13-10-2018 IPR036526 Carbon-nitrogen hydrolase superfamily TOPB45_1462 991fa4ecff8750eba7897a432d3fb9b2 530 Hamap MF_01148 Apolipoprotein N-acyltransferase [lnt]. 3 511 19.971 T 13-10-2018 IPR004563 Apolipoprotein N-acyltransferase GO:0016021|GO:0016410|GO:0042158 TOPB45_1462 991fa4ecff8750eba7897a432d3fb9b2 530 Pfam PF00795 Carbon-nitrogen hydrolase 236 491 1.6E-23 T 13-10-2018 IPR003010 Carbon-nitrogen hydrolase GO:0006807 TOPB45_1462 991fa4ecff8750eba7897a432d3fb9b2 530 SUPERFAMILY SSF56317 231 502 2.88E-39 T 13-10-2018 IPR036526 Carbon-nitrogen hydrolase superfamily TOPB45_1462 991fa4ecff8750eba7897a432d3fb9b2 530 TIGRFAM TIGR00546 lnt: apolipoprotein N-acyltransferase 57 473 5.6E-85 T 13-10-2018 IPR004563 Apolipoprotein N-acyltransferase GO:0016021|GO:0016410|GO:0042158 TOPB45_0900 3fbfaabe395364793a2a1ff3343424e4 431 Pfam PF01925 Sulfite exporter TauE/SafE 282 402 2.4E-18 T 13-10-2018 IPR002781 Transmembrane protein TauE-like GO:0016021 TOPB45_0900 3fbfaabe395364793a2a1ff3343424e4 431 SUPERFAMILY SSF103473 269 420 1.01E-6 T 13-10-2018 IPR036259 MFS transporter superfamily TOPB45_0001 a122fff52988097af299da9f415cd143 448 Hamap MF_00377 Chromosomal replication initiator protein DnaA [dnaA]. 6 432 23.794 T 13-10-2018 IPR001957 Chromosomal replication control, initiator DnaA GO:0003677|GO:0003688|GO:0005524|GO:0006270|GO:0006275 TOPB45_0001 a122fff52988097af299da9f415cd143 448 Pfam PF00308 Bacterial dnaA protein 101 316 1.4E-60 T 13-10-2018 IPR013317 Chromosomal replication initiator protein DnaA TOPB45_0001 a122fff52988097af299da9f415cd143 448 Gene3D G3DSA:1.10.1750.10 334 436 7.7E-24 T 13-10-2018 IPR010921 Trp repressor/replication initiator GO:0043565 TOPB45_0001 a122fff52988097af299da9f415cd143 448 SMART SM00382 132 264 3.0E-8 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_0001 a122fff52988097af299da9f415cd143 448 Gene3D G3DSA:3.40.50.300 99 265 1.0E-39 T 13-10-2018 TOPB45_0001 a122fff52988097af299da9f415cd143 448 SUPERFAMILY SSF48295 341 432 3.14E-23 T 13-10-2018 IPR010921 Trp repressor/replication initiator GO:0043565 TOPB45_0001 a122fff52988097af299da9f415cd143 448 PRINTS PR00051 Bacterial chromosomal replication initiator (DNAA) signature 133 153 4.9E-23 T 13-10-2018 IPR020591 Chromosomal replication control, initiator DnaA-like TOPB45_0001 a122fff52988097af299da9f415cd143 448 PRINTS PR00051 Bacterial chromosomal replication initiator (DNAA) signature 231 258 4.9E-23 T 13-10-2018 IPR020591 Chromosomal replication control, initiator DnaA-like TOPB45_0001 a122fff52988097af299da9f415cd143 448 PRINTS PR00051 Bacterial chromosomal replication initiator (DNAA) signature 164 178 4.9E-23 T 13-10-2018 IPR020591 Chromosomal replication control, initiator DnaA-like TOPB45_0001 a122fff52988097af299da9f415cd143 448 PRINTS PR00051 Bacterial chromosomal replication initiator (DNAA) signature 391 410 4.9E-23 T 13-10-2018 IPR020591 Chromosomal replication control, initiator DnaA-like TOPB45_0001 a122fff52988097af299da9f415cd143 448 PRINTS PR00051 Bacterial chromosomal replication initiator (DNAA) signature 197 211 4.9E-23 T 13-10-2018 IPR020591 Chromosomal replication control, initiator DnaA-like TOPB45_0001 a122fff52988097af299da9f415cd143 448 TIGRFAM TIGR00362 DnaA: chromosomal replication initiator protein DnaA 9 430 3.5E-110 T 13-10-2018 IPR001957 Chromosomal replication control, initiator DnaA GO:0003677|GO:0003688|GO:0005524|GO:0006270|GO:0006275 TOPB45_0001 a122fff52988097af299da9f415cd143 448 Pfam PF08299 Bacterial dnaA protein helix-turn-helix 343 408 3.3E-21 T 13-10-2018 IPR013159 Chromosomal replication initiator, DnaA C-terminal GO:0005524|GO:0006270|GO:0006275|GO:0043565 TOPB45_0001 a122fff52988097af299da9f415cd143 448 Gene3D G3DSA:1.10.8.60 266 333 4.1E-16 T 13-10-2018 TOPB45_0001 a122fff52988097af299da9f415cd143 448 Gene3D G3DSA:3.30.300.180 6 96 2.4E-14 T 13-10-2018 IPR038454 DnaA, N-terminal domain superfamily TOPB45_0001 a122fff52988097af299da9f415cd143 448 SUPERFAMILY SSF52540 101 307 5.1E-37 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0001 a122fff52988097af299da9f415cd143 448 Pfam PF11638 DnaA N-terminal domain 9 67 4.5E-14 T 13-10-2018 IPR024633 DnaA N-terminal domain TOPB45_0001 a122fff52988097af299da9f415cd143 448 SMART SM00760 342 410 2.3E-20 T 13-10-2018 IPR013159 Chromosomal replication initiator, DnaA C-terminal GO:0005524|GO:0006270|GO:0006275|GO:0043565 TOPB45_0697 5b318f2c8f97ad9865792acd5eeea4d7 418 PRINTS PR01181 Diaminopimelate decarboxylase signature 164 173 1.4E-30 T 13-10-2018 IPR002986 Diaminopimelate decarboxylase, LysA GO:0008836|GO:0009089 KEGG: 00300+4.1.1.20|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TOPB45_0697 5b318f2c8f97ad9865792acd5eeea4d7 418 PRINTS PR01181 Diaminopimelate decarboxylase signature 379 401 1.4E-30 T 13-10-2018 IPR002986 Diaminopimelate decarboxylase, LysA GO:0008836|GO:0009089 KEGG: 00300+4.1.1.20|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TOPB45_0697 5b318f2c8f97ad9865792acd5eeea4d7 418 PRINTS PR01181 Diaminopimelate decarboxylase signature 75 92 1.4E-30 T 13-10-2018 IPR002986 Diaminopimelate decarboxylase, LysA GO:0008836|GO:0009089 KEGG: 00300+4.1.1.20|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TOPB45_0697 5b318f2c8f97ad9865792acd5eeea4d7 418 PRINTS PR01181 Diaminopimelate decarboxylase signature 298 316 1.4E-30 T 13-10-2018 IPR002986 Diaminopimelate decarboxylase, LysA GO:0008836|GO:0009089 KEGG: 00300+4.1.1.20|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TOPB45_0697 5b318f2c8f97ad9865792acd5eeea4d7 418 SUPERFAMILY SSF50621 253 414 1.63E-59 T 13-10-2018 IPR009006 Alanine racemase/group IV decarboxylase, C-terminal GO:0003824 TOPB45_0697 5b318f2c8f97ad9865792acd5eeea4d7 418 Gene3D G3DSA:3.20.20.10 34 275 2.1E-160 T 13-10-2018 IPR029066 PLP-binding barrel TOPB45_0697 5b318f2c8f97ad9865792acd5eeea4d7 418 Pfam PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 36 279 3.3E-64 T 13-10-2018 IPR022644 Orn/DAP/Arg decarboxylase 2, N-terminal GO:0003824 TOPB45_0697 5b318f2c8f97ad9865792acd5eeea4d7 418 Gene3D G3DSA:2.40.37.10 13 409 2.1E-160 T 13-10-2018 IPR009006 Alanine racemase/group IV decarboxylase, C-terminal GO:0003824 TOPB45_0697 5b318f2c8f97ad9865792acd5eeea4d7 418 ProSitePatterns PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2. 228 241 - T 13-10-2018 IPR022657 Orn/DAP/Arg decarboxylase 2, conserved site TOPB45_0697 5b318f2c8f97ad9865792acd5eeea4d7 418 SUPERFAMILY SSF51419 26 282 2.47E-82 T 13-10-2018 IPR029066 PLP-binding barrel TOPB45_0697 5b318f2c8f97ad9865792acd5eeea4d7 418 Hamap MF_02120 Diaminopimelate decarboxylase [lysA]. 15 412 43.612 T 13-10-2018 IPR002986 Diaminopimelate decarboxylase, LysA GO:0008836|GO:0009089 KEGG: 00300+4.1.1.20|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TOPB45_0697 5b318f2c8f97ad9865792acd5eeea4d7 418 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 270 289 5.0E-24 T 13-10-2018 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 TOPB45_0697 5b318f2c8f97ad9865792acd5eeea4d7 418 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 57 75 5.0E-24 T 13-10-2018 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 TOPB45_0697 5b318f2c8f97ad9865792acd5eeea4d7 418 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 190 203 5.0E-24 T 13-10-2018 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 TOPB45_0697 5b318f2c8f97ad9865792acd5eeea4d7 418 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 369 382 5.0E-24 T 13-10-2018 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 TOPB45_0697 5b318f2c8f97ad9865792acd5eeea4d7 418 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 77 89 5.0E-24 T 13-10-2018 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 TOPB45_0697 5b318f2c8f97ad9865792acd5eeea4d7 418 TIGRFAM TIGR01048 lysA: diaminopimelate decarboxylase 7 411 2.0E-165 T 13-10-2018 IPR002986 Diaminopimelate decarboxylase, LysA GO:0008836|GO:0009089 KEGG: 00300+4.1.1.20|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 TOPB45_0697 5b318f2c8f97ad9865792acd5eeea4d7 418 Pfam PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 280 369 2.0E-30 T 13-10-2018 IPR022643 Orn/DAP/Arg decarboxylase 2, C-terminal GO:0003824 TOPB45_1444 c3aa7100352f6b19db780055dae3b909 163 PIRSF PIRSF006443 1 157 3.8E-40 T 13-10-2018 IPR012245 Molybdenum cofactor biosynthesis protein MoaB GO:0006777 TOPB45_1444 c3aa7100352f6b19db780055dae3b909 163 Pfam PF00994 Probable molybdopterin binding domain 5 148 6.3E-38 T 13-10-2018 IPR001453 MoaB/Mog domain TOPB45_1444 c3aa7100352f6b19db780055dae3b909 163 TIGRFAM TIGR00177 molyb_syn: molybdenum cofactor synthesis domain 2 143 5.3E-38 T 13-10-2018 IPR001453 MoaB/Mog domain TOPB45_1444 c3aa7100352f6b19db780055dae3b909 163 SUPERFAMILY SSF53218 2 154 7.72E-47 T 13-10-2018 IPR036425 MoaB/Mog-like domain superfamily TOPB45_1444 c3aa7100352f6b19db780055dae3b909 163 ProSitePatterns PS01078 Molybdenum cofactor biosynthesis proteins signature 1. 65 78 - T 13-10-2018 IPR008284 Molybdenum cofactor biosynthesis, conserved site GO:0006777 Reactome: R-HSA-947581 TOPB45_1444 c3aa7100352f6b19db780055dae3b909 163 Gene3D G3DSA:3.40.980.10 1 163 6.8E-59 T 13-10-2018 IPR036425 MoaB/Mog-like domain superfamily TOPB45_1444 c3aa7100352f6b19db780055dae3b909 163 SMART SM00852 5 149 2.9E-27 T 13-10-2018 IPR001453 MoaB/Mog domain TOPB45_0265 d63641d55f6b19cfafe75296ee321962 778 PRINTS PR00983 Cysteinyl-tRNA synthetase signature 504 522 1.2E-11 T 13-10-2018 IPR024909 Cysteinyl-tRNA synthetase/mycothiol ligase KEGG: 00970+6.1.1.16 TOPB45_0265 d63641d55f6b19cfafe75296ee321962 778 PRINTS PR00983 Cysteinyl-tRNA synthetase signature 370 379 1.2E-11 T 13-10-2018 IPR024909 Cysteinyl-tRNA synthetase/mycothiol ligase KEGG: 00970+6.1.1.16 TOPB45_0265 d63641d55f6b19cfafe75296ee321962 778 PRINTS PR00983 Cysteinyl-tRNA synthetase signature 334 345 1.2E-11 T 13-10-2018 IPR024909 Cysteinyl-tRNA synthetase/mycothiol ligase KEGG: 00970+6.1.1.16 TOPB45_0265 d63641d55f6b19cfafe75296ee321962 778 PRINTS PR00983 Cysteinyl-tRNA synthetase signature 535 556 1.2E-11 T 13-10-2018 IPR024909 Cysteinyl-tRNA synthetase/mycothiol ligase KEGG: 00970+6.1.1.16 TOPB45_0265 d63641d55f6b19cfafe75296ee321962 778 ProSitePatterns PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. 32 50 - T 13-10-2018 IPR001216 Cysteine synthase/cystathionine beta-synthase, pyridoxal-phosphate attachment site GO:0006535 TOPB45_0265 d63641d55f6b19cfafe75296ee321962 778 Pfam PF01406 tRNA synthetases class I (C) catalytic domain 326 624 4.6E-78 T 13-10-2018 IPR032678 tRNA synthetases class I, catalytic domain KEGG: 00970+6.1.1.16 TOPB45_0265 d63641d55f6b19cfafe75296ee321962 778 Gene3D G3DSA:1.20.120.1910 617 773 8.2E-20 T 13-10-2018 TOPB45_0265 d63641d55f6b19cfafe75296ee321962 778 Hamap MF_00041 Cysteine--tRNA ligase [cysS]. 311 774 26.717 T 13-10-2018 IPR015803 Cysteine-tRNA ligase GO:0004817|GO:0005524|GO:0006423 KEGG: 00970+6.1.1.16 TOPB45_0265 d63641d55f6b19cfafe75296ee321962 778 Gene3D G3DSA:3.40.50.620 293 616 1.6E-88 T 13-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TOPB45_0265 d63641d55f6b19cfafe75296ee321962 778 TIGRFAM TIGR01136 cysKM: cysteine synthase 7 296 1.4E-111 T 13-10-2018 IPR005856 Cysteine synthase GO:0004124|GO:0006535 KEGG: 00270+2.5.1.47|KEGG: 00920+2.5.1.47|MetaCyc: PWY-6936 TOPB45_0265 d63641d55f6b19cfafe75296ee321962 778 TIGRFAM TIGR00435 cysS: cysteine--tRNA ligase 311 771 2.8E-106 T 13-10-2018 IPR015803 Cysteine-tRNA ligase GO:0004817|GO:0005524|GO:0006423 KEGG: 00970+6.1.1.16 TOPB45_0265 d63641d55f6b19cfafe75296ee321962 778 Gene3D G3DSA:3.40.50.1100 44 144 1.4E-107 T 13-10-2018 TOPB45_0265 d63641d55f6b19cfafe75296ee321962 778 Gene3D G3DSA:3.40.50.1100 5 292 1.4E-107 T 13-10-2018 TOPB45_0265 d63641d55f6b19cfafe75296ee321962 778 SUPERFAMILY SSF53686 2 298 7.46E-92 T 13-10-2018 IPR036052 Tryptophan synthase beta subunit-like PLP-dependent enzyme TOPB45_0265 d63641d55f6b19cfafe75296ee321962 778 SUPERFAMILY SSF47323 651 771 4.18E-18 T 13-10-2018 IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 TOPB45_0265 d63641d55f6b19cfafe75296ee321962 778 SUPERFAMILY SSF52374 314 624 6.44E-64 T 13-10-2018 TOPB45_0265 d63641d55f6b19cfafe75296ee321962 778 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 8 285 8.0E-70 T 13-10-2018 IPR001926 Pyridoxal-phosphate dependent enzyme TOPB45_1579 6569f4d6ad1d2e2be13864a5f3b835d0 411 Pfam PF05977 Transmembrane secretion effector 14 404 1.4E-52 T 13-10-2018 IPR010290 Transmembrane secretion effector TOPB45_1579 6569f4d6ad1d2e2be13864a5f3b835d0 411 Gene3D G3DSA:1.20.1250.20 17 405 2.6E-44 T 13-10-2018 TOPB45_1579 6569f4d6ad1d2e2be13864a5f3b835d0 411 SUPERFAMILY SSF103473 18 406 2.35E-52 T 13-10-2018 IPR036259 MFS transporter superfamily TOPB45_1156 eac2690f0b0e869bf8da272b4853c47f 365 Gene3D G3DSA:3.40.640.10 44 269 8.9E-109 T 13-10-2018 IPR015421 Pyridoxal phosphate-dependent transferase, major domain GO:0003824 TOPB45_1156 eac2690f0b0e869bf8da272b4853c47f 365 Pfam PF00155 Aminotransferase class I and II 32 351 5.2E-57 T 13-10-2018 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 TOPB45_1156 eac2690f0b0e869bf8da272b4853c47f 365 TIGRFAM TIGR01141 hisC: histidinol-phosphate transaminase 5 360 6.8E-107 T 13-10-2018 IPR005861 Histidinol-phosphate aminotransferase family GO:0000105|GO:0004400 KEGG: 00340+2.6.1.9|KEGG: 00350+2.6.1.9|KEGG: 00360+2.6.1.9|KEGG: 00400+2.6.1.9|KEGG: 00401+2.6.1.9|KEGG: 00960+2.6.1.9 TOPB45_1156 eac2690f0b0e869bf8da272b4853c47f 365 Hamap MF_01023 Histidinol-phosphate aminotransferase [hisC]. 2 361 57.176 T 13-10-2018 IPR005861 Histidinol-phosphate aminotransferase family GO:0000105|GO:0004400 KEGG: 00340+2.6.1.9|KEGG: 00350+2.6.1.9|KEGG: 00360+2.6.1.9|KEGG: 00400+2.6.1.9|KEGG: 00401+2.6.1.9|KEGG: 00960+2.6.1.9 TOPB45_1156 eac2690f0b0e869bf8da272b4853c47f 365 SUPERFAMILY SSF53383 5 358 1.5E-80 T 13-10-2018 IPR015424 Pyridoxal phosphate-dependent transferase TOPB45_1156 eac2690f0b0e869bf8da272b4853c47f 365 ProSitePatterns PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 221 230 - T 13-10-2018 IPR001917 Aminotransferase, class-II, pyridoxal-phosphate binding site GO:0016740 TOPB45_1156 eac2690f0b0e869bf8da272b4853c47f 365 Gene3D G3DSA:3.90.1150.10 8 354 8.9E-109 T 13-10-2018 IPR015422 Pyridoxal phosphate-dependent transferase domain 1 GO:0003824 TOPB45_0751 372b3aaa6d18c94e20cab52b3dc9ef5b 399 TIGRFAM TIGR00485 EF-Tu: translation elongation factor Tu 1 399 1.4E-218 T 13-10-2018 IPR004541 Translation elongation factor EFTu/EF1A, bacterial/organelle GO:0003746|GO:0005525|GO:0005622|GO:0006414 Reactome: R-HSA-5389840 TOPB45_0751 372b3aaa6d18c94e20cab52b3dc9ef5b 399 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 14 146 2.6E-14 T 13-10-2018 IPR005225 Small GTP-binding protein domain GO:0005525 TOPB45_0751 372b3aaa6d18c94e20cab52b3dc9ef5b 399 PRINTS PR00315 GTP-binding elongation factor signature 58 66 5.8E-24 T 13-10-2018 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TOPB45_0751 372b3aaa6d18c94e20cab52b3dc9ef5b 399 PRINTS PR00315 GTP-binding elongation factor signature 131 140 5.8E-24 T 13-10-2018 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TOPB45_0751 372b3aaa6d18c94e20cab52b3dc9ef5b 399 PRINTS PR00315 GTP-binding elongation factor signature 14 27 5.8E-24 T 13-10-2018 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TOPB45_0751 372b3aaa6d18c94e20cab52b3dc9ef5b 399 PRINTS PR00315 GTP-binding elongation factor signature 78 88 5.8E-24 T 13-10-2018 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TOPB45_0751 372b3aaa6d18c94e20cab52b3dc9ef5b 399 PRINTS PR00315 GTP-binding elongation factor signature 94 105 5.8E-24 T 13-10-2018 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TOPB45_0751 372b3aaa6d18c94e20cab52b3dc9ef5b 399 Gene3D G3DSA:3.40.50.300 1 208 1.6E-67 T 13-10-2018 TOPB45_0751 372b3aaa6d18c94e20cab52b3dc9ef5b 399 Pfam PF03143 Elongation factor Tu C-terminal domain 303 397 6.1E-35 T 13-10-2018 IPR004160 Translation elongation factor EFTu/EF1A, C-terminal TOPB45_0751 372b3aaa6d18c94e20cab52b3dc9ef5b 399 Gene3D G3DSA:2.40.30.10 343 398 2.9E-30 T 13-10-2018 TOPB45_0751 372b3aaa6d18c94e20cab52b3dc9ef5b 399 Pfam PF03144 Elongation factor Tu domain 2 230 298 2.4E-17 T 13-10-2018 IPR004161 Translation elongation factor EFTu-like, domain 2 GO:0005525 TOPB45_0751 372b3aaa6d18c94e20cab52b3dc9ef5b 399 SUPERFAMILY SSF52540 8 231 2.66E-61 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0751 372b3aaa6d18c94e20cab52b3dc9ef5b 399 Hamap MF_00118_B Elongation factor Tu [tuf]. 1 399 60.06 T 13-10-2018 IPR004541 Translation elongation factor EFTu/EF1A, bacterial/organelle GO:0003746|GO:0005525|GO:0005622|GO:0006414 Reactome: R-HSA-5389840 TOPB45_0751 372b3aaa6d18c94e20cab52b3dc9ef5b 399 SUPERFAMILY SSF50447 210 306 4.12E-32 T 13-10-2018 IPR009000 Translation protein, beta-barrel domain superfamily TOPB45_0751 372b3aaa6d18c94e20cab52b3dc9ef5b 399 ProSitePatterns PS00301 Translational (tr)-type guanine nucleotide-binding (G) domain signature. 51 66 - T 13-10-2018 IPR031157 Tr-type G domain, conserved site TOPB45_0751 372b3aaa6d18c94e20cab52b3dc9ef5b 399 SUPERFAMILY SSF50465 303 398 2.19E-37 T 13-10-2018 IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal TOPB45_0751 372b3aaa6d18c94e20cab52b3dc9ef5b 399 Pfam PF00009 Elongation factor Tu GTP binding domain 10 206 8.0E-57 T 13-10-2018 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TOPB45_0751 372b3aaa6d18c94e20cab52b3dc9ef5b 399 Gene3D G3DSA:2.40.30.10 211 339 1.7E-54 T 13-10-2018 TOPB45_0172 372b3aaa6d18c94e20cab52b3dc9ef5b 399 TIGRFAM TIGR00485 EF-Tu: translation elongation factor Tu 1 399 1.4E-218 T 13-10-2018 IPR004541 Translation elongation factor EFTu/EF1A, bacterial/organelle GO:0003746|GO:0005525|GO:0005622|GO:0006414 Reactome: R-HSA-5389840 TOPB45_0172 372b3aaa6d18c94e20cab52b3dc9ef5b 399 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 14 146 2.6E-14 T 13-10-2018 IPR005225 Small GTP-binding protein domain GO:0005525 TOPB45_0172 372b3aaa6d18c94e20cab52b3dc9ef5b 399 PRINTS PR00315 GTP-binding elongation factor signature 58 66 5.8E-24 T 13-10-2018 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TOPB45_0172 372b3aaa6d18c94e20cab52b3dc9ef5b 399 PRINTS PR00315 GTP-binding elongation factor signature 131 140 5.8E-24 T 13-10-2018 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TOPB45_0172 372b3aaa6d18c94e20cab52b3dc9ef5b 399 PRINTS PR00315 GTP-binding elongation factor signature 14 27 5.8E-24 T 13-10-2018 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TOPB45_0172 372b3aaa6d18c94e20cab52b3dc9ef5b 399 PRINTS PR00315 GTP-binding elongation factor signature 78 88 5.8E-24 T 13-10-2018 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TOPB45_0172 372b3aaa6d18c94e20cab52b3dc9ef5b 399 PRINTS PR00315 GTP-binding elongation factor signature 94 105 5.8E-24 T 13-10-2018 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TOPB45_0172 372b3aaa6d18c94e20cab52b3dc9ef5b 399 Gene3D G3DSA:3.40.50.300 1 208 1.6E-67 T 13-10-2018 TOPB45_0172 372b3aaa6d18c94e20cab52b3dc9ef5b 399 Pfam PF03143 Elongation factor Tu C-terminal domain 303 397 6.1E-35 T 13-10-2018 IPR004160 Translation elongation factor EFTu/EF1A, C-terminal TOPB45_0172 372b3aaa6d18c94e20cab52b3dc9ef5b 399 Gene3D G3DSA:2.40.30.10 343 398 2.9E-30 T 13-10-2018 TOPB45_0172 372b3aaa6d18c94e20cab52b3dc9ef5b 399 Pfam PF03144 Elongation factor Tu domain 2 230 298 2.4E-17 T 13-10-2018 IPR004161 Translation elongation factor EFTu-like, domain 2 GO:0005525 TOPB45_0172 372b3aaa6d18c94e20cab52b3dc9ef5b 399 SUPERFAMILY SSF52540 8 231 2.66E-61 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0172 372b3aaa6d18c94e20cab52b3dc9ef5b 399 Hamap MF_00118_B Elongation factor Tu [tuf]. 1 399 60.06 T 13-10-2018 IPR004541 Translation elongation factor EFTu/EF1A, bacterial/organelle GO:0003746|GO:0005525|GO:0005622|GO:0006414 Reactome: R-HSA-5389840 TOPB45_0172 372b3aaa6d18c94e20cab52b3dc9ef5b 399 SUPERFAMILY SSF50447 210 306 4.12E-32 T 13-10-2018 IPR009000 Translation protein, beta-barrel domain superfamily TOPB45_0172 372b3aaa6d18c94e20cab52b3dc9ef5b 399 ProSitePatterns PS00301 Translational (tr)-type guanine nucleotide-binding (G) domain signature. 51 66 - T 13-10-2018 IPR031157 Tr-type G domain, conserved site TOPB45_0172 372b3aaa6d18c94e20cab52b3dc9ef5b 399 SUPERFAMILY SSF50465 303 398 2.19E-37 T 13-10-2018 IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal TOPB45_0172 372b3aaa6d18c94e20cab52b3dc9ef5b 399 Pfam PF00009 Elongation factor Tu GTP binding domain 10 206 8.0E-57 T 13-10-2018 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 TOPB45_0172 372b3aaa6d18c94e20cab52b3dc9ef5b 399 Gene3D G3DSA:2.40.30.10 211 339 1.7E-54 T 13-10-2018 TOPB45_1525 fa8a32aedfdfc46c201238f8f98347b5 106 SUPERFAMILY SSF69721 2 106 1.44E-35 T 13-10-2018 IPR025526 DsrC-like domain superfamily TOPB45_1525 fa8a32aedfdfc46c201238f8f98347b5 106 TIGRFAM TIGR03342 dsrC_tusE_dsvC: sulfur relay protein, TusE/DsrC/DsvC family 5 106 5.5E-32 T 13-10-2018 IPR007453 Sulphur transfer protein DsrC/TusE TOPB45_1525 fa8a32aedfdfc46c201238f8f98347b5 106 Pfam PF04358 DsrC like protein 6 106 3.2E-33 T 13-10-2018 IPR007453 Sulphur transfer protein DsrC/TusE TOPB45_1525 fa8a32aedfdfc46c201238f8f98347b5 106 Gene3D G3DSA:1.10.10.370 43 106 7.6E-28 T 13-10-2018 TOPB45_1525 fa8a32aedfdfc46c201238f8f98347b5 106 Gene3D G3DSA:3.30.1420.10 1 42 2.1E-16 T 13-10-2018 TOPB45_1525 fa8a32aedfdfc46c201238f8f98347b5 106 PIRSF PIRSF006223 4 106 3.1E-31 T 13-10-2018 IPR007453 Sulphur transfer protein DsrC/TusE TOPB45_1391 99c69504e204cc69d1486a9391b8abe1 238 TIGRFAM TIGR04406 LPS_export_lptB: LPS export ABC transporter ATP-binding protein 2 237 2.3E-98 T 13-10-2018 IPR030921 LPS export ABC transporter, ATP-binding protein LptB GO:0043190|GO:0055085 TOPB45_1391 99c69504e204cc69d1486a9391b8abe1 238 Gene3D G3DSA:3.40.50.300 1 235 2.6E-64 T 13-10-2018 TOPB45_1391 99c69504e204cc69d1486a9391b8abe1 238 Pfam PF00005 ABC transporter 17 163 7.9E-36 T 13-10-2018 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TOPB45_1391 99c69504e204cc69d1486a9391b8abe1 238 ProSitePatterns PS00211 ABC transporters family signature. 135 149 - T 13-10-2018 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TOPB45_1391 99c69504e204cc69d1486a9391b8abe1 238 SMART SM00382 26 232 1.3E-8 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_1391 99c69504e204cc69d1486a9391b8abe1 238 SUPERFAMILY SSF52540 2 226 2.08E-62 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0775 fc43692c1756b5c07278ac9a8a09038f 257 Pfam PF00557 Metallopeptidase family M24 20 248 2.5E-48 T 13-10-2018 IPR000994 Peptidase M24 TOPB45_0775 fc43692c1756b5c07278ac9a8a09038f 257 Gene3D G3DSA:3.90.230.10 8 256 3.1E-99 T 13-10-2018 TOPB45_0775 fc43692c1756b5c07278ac9a8a09038f 257 ProSitePatterns PS00680 Methionine aminopeptidase subfamily 1 signature. 174 192 - T 13-10-2018 IPR002467 Peptidase M24A, methionine aminopeptidase, subfamily 1 GO:0004177|GO:0006508|GO:0008235 MetaCyc: PWY-7799|MetaCyc: PWY-7800 TOPB45_0775 fc43692c1756b5c07278ac9a8a09038f 257 TIGRFAM TIGR00500 met_pdase_I: methionine aminopeptidase, type I 12 256 1.2E-94 T 13-10-2018 IPR002467 Peptidase M24A, methionine aminopeptidase, subfamily 1 GO:0004177|GO:0006508|GO:0008235 MetaCyc: PWY-7799|MetaCyc: PWY-7800 TOPB45_0775 fc43692c1756b5c07278ac9a8a09038f 257 PRINTS PR00599 Methionine aminopeptidase-1 signature 199 211 4.1E-21 T 13-10-2018 IPR001714 Peptidase M24, methionine aminopeptidase MetaCyc: PWY-7799|MetaCyc: PWY-7800 TOPB45_0775 fc43692c1756b5c07278ac9a8a09038f 257 PRINTS PR00599 Methionine aminopeptidase-1 signature 75 88 4.1E-21 T 13-10-2018 IPR001714 Peptidase M24, methionine aminopeptidase MetaCyc: PWY-7799|MetaCyc: PWY-7800 TOPB45_0775 fc43692c1756b5c07278ac9a8a09038f 257 PRINTS PR00599 Methionine aminopeptidase-1 signature 98 114 4.1E-21 T 13-10-2018 IPR001714 Peptidase M24, methionine aminopeptidase MetaCyc: PWY-7799|MetaCyc: PWY-7800 TOPB45_0775 fc43692c1756b5c07278ac9a8a09038f 257 PRINTS PR00599 Methionine aminopeptidase-1 signature 168 180 4.1E-21 T 13-10-2018 IPR001714 Peptidase M24, methionine aminopeptidase MetaCyc: PWY-7799|MetaCyc: PWY-7800 TOPB45_0775 fc43692c1756b5c07278ac9a8a09038f 257 SUPERFAMILY SSF55920 12 256 1.06E-80 T 13-10-2018 IPR036005 Creatinase/aminopeptidase-like TOPB45_0775 fc43692c1756b5c07278ac9a8a09038f 257 Hamap MF_01974 Methionine aminopeptidase [map]. 10 257 38.965 T 13-10-2018 IPR002467 Peptidase M24A, methionine aminopeptidase, subfamily 1 GO:0004177|GO:0006508|GO:0008235 MetaCyc: PWY-7799|MetaCyc: PWY-7800 TOPB45_1457 c52ce7ee011b969a97ec3194acb682d9 305 Pfam PF01379 Porphobilinogen deaminase, dipyromethane cofactor binding domain 3 208 5.3E-78 T 13-10-2018 IPR022417 Porphobilinogen deaminase, N-terminal GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 TOPB45_1457 c52ce7ee011b969a97ec3194acb682d9 305 PIRSF PIRSF001438 1 305 4.2E-117 T 13-10-2018 IPR000860 Porphobilinogen deaminase GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 TOPB45_1457 c52ce7ee011b969a97ec3194acb682d9 305 SUPERFAMILY SSF54782 216 303 7.98E-25 T 13-10-2018 IPR036803 Porphobilinogen deaminase, C-terminal domain superfamily GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 TOPB45_1457 c52ce7ee011b969a97ec3194acb682d9 305 Gene3D G3DSA:3.40.190.10 100 197 4.5E-81 T 13-10-2018 TOPB45_1457 c52ce7ee011b969a97ec3194acb682d9 305 Hamap MF_00260 Porphobilinogen deaminase [hemC]. 2 292 38.158 T 13-10-2018 IPR000860 Porphobilinogen deaminase GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 TOPB45_1457 c52ce7ee011b969a97ec3194acb682d9 305 Gene3D G3DSA:3.40.190.10 3 205 4.5E-81 T 13-10-2018 TOPB45_1457 c52ce7ee011b969a97ec3194acb682d9 305 TIGRFAM TIGR00212 hemC: hydroxymethylbilane synthase 3 292 9.0E-111 T 13-10-2018 IPR000860 Porphobilinogen deaminase GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 TOPB45_1457 c52ce7ee011b969a97ec3194acb682d9 305 Pfam PF03900 Porphobilinogen deaminase, C-terminal domain 221 290 7.3E-18 T 13-10-2018 IPR022418 Porphobilinogen deaminase, C-terminal GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 TOPB45_1457 c52ce7ee011b969a97ec3194acb682d9 305 PRINTS PR00151 Porphobilinogen deaminase signature 42 62 1.1E-46 T 13-10-2018 IPR000860 Porphobilinogen deaminase GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 TOPB45_1457 c52ce7ee011b969a97ec3194acb682d9 305 PRINTS PR00151 Porphobilinogen deaminase signature 73 92 1.1E-46 T 13-10-2018 IPR000860 Porphobilinogen deaminase GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 TOPB45_1457 c52ce7ee011b969a97ec3194acb682d9 305 PRINTS PR00151 Porphobilinogen deaminase signature 225 242 1.1E-46 T 13-10-2018 IPR000860 Porphobilinogen deaminase GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 TOPB45_1457 c52ce7ee011b969a97ec3194acb682d9 305 PRINTS PR00151 Porphobilinogen deaminase signature 139 156 1.1E-46 T 13-10-2018 IPR000860 Porphobilinogen deaminase GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 TOPB45_1457 c52ce7ee011b969a97ec3194acb682d9 305 PRINTS PR00151 Porphobilinogen deaminase signature 120 137 1.1E-46 T 13-10-2018 IPR000860 Porphobilinogen deaminase GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 TOPB45_1457 c52ce7ee011b969a97ec3194acb682d9 305 ProSitePatterns PS00533 Porphobilinogen deaminase cofactor-binding site. 226 242 - T 13-10-2018 IPR022419 Porphobilinogen deaminase, dipyrromethane cofactor binding site GO:0004418|GO:0018160|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 TOPB45_1457 c52ce7ee011b969a97ec3194acb682d9 305 SUPERFAMILY SSF53850 2 213 1.28E-78 T 13-10-2018 TOPB45_1457 c52ce7ee011b969a97ec3194acb682d9 305 Gene3D G3DSA:3.30.160.40 215 301 5.9E-24 T 13-10-2018 IPR036803 Porphobilinogen deaminase, C-terminal domain superfamily GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 TOPB45_0577 aaca17716f86072854a846c49c21e342 169 Gene3D G3DSA:3.30.420.10 3 162 2.9E-33 T 13-10-2018 IPR036397 Ribonuclease H superfamily GO:0003676 TOPB45_0577 aaca17716f86072854a846c49c21e342 169 SUPERFAMILY SSF53098 1 159 1.18E-25 T 13-10-2018 IPR012337 Ribonuclease H-like superfamily TOPB45_0577 aaca17716f86072854a846c49c21e342 169 Pfam PF02075 Crossover junction endodeoxyribonuclease RuvC 3 155 1.9E-17 T 13-10-2018 IPR002176 Crossover junction endodeoxyribonuclease RuvC GO:0004520|GO:0006281|GO:0006310 TOPB45_0577 aaca17716f86072854a846c49c21e342 169 PRINTS PR00696 Crossover junction endodeoxyribonuclease RUVC signature 83 99 1.4E-12 T 13-10-2018 IPR002176 Crossover junction endodeoxyribonuclease RuvC GO:0004520|GO:0006281|GO:0006310 TOPB45_0577 aaca17716f86072854a846c49c21e342 169 PRINTS PR00696 Crossover junction endodeoxyribonuclease RUVC signature 61 77 1.4E-12 T 13-10-2018 IPR002176 Crossover junction endodeoxyribonuclease RuvC GO:0004520|GO:0006281|GO:0006310 TOPB45_0577 aaca17716f86072854a846c49c21e342 169 PRINTS PR00696 Crossover junction endodeoxyribonuclease RUVC signature 4 17 1.4E-12 T 13-10-2018 IPR002176 Crossover junction endodeoxyribonuclease RuvC GO:0004520|GO:0006281|GO:0006310 TOPB45_0577 aaca17716f86072854a846c49c21e342 169 PRINTS PR00696 Crossover junction endodeoxyribonuclease RUVC signature 107 126 1.4E-12 T 13-10-2018 IPR002176 Crossover junction endodeoxyribonuclease RuvC GO:0004520|GO:0006281|GO:0006310 TOPB45_1450 cd5f276677e1dcce7a8cf4288cd126bb 238 SUPERFAMILY SSF54862 2 172 2.2E-61 T 13-10-2018 TOPB45_1450 cd5f276677e1dcce7a8cf4288cd126bb 238 Pfam PF12800 4Fe-4S binding domain 10 25 0.026 T 13-10-2018 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain TOPB45_1450 cd5f276677e1dcce7a8cf4288cd126bb 238 Gene3D G3DSA:3.30.70.20 6 171 4.5E-65 T 13-10-2018 TOPB45_1450 cd5f276677e1dcce7a8cf4288cd126bb 238 Pfam PF13247 4Fe-4S dicluster domain 65 162 3.7E-32 T 13-10-2018 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain TOPB45_1450 cd5f276677e1dcce7a8cf4288cd126bb 238 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 107 118 - T 13-10-2018 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site TOPB45_1450 cd5f276677e1dcce7a8cf4288cd126bb 238 Gene3D G3DSA:3.30.70.20 76 134 4.5E-65 T 13-10-2018 TOPB45_1389 1d19fc6807207e313603c8e57b0cd2a3 168 Pfam PF16321 Sigma 54 modulation/S30EA ribosomal protein C terminus 116 158 2.0E-7 T 13-10-2018 IPR032528 Sigma 54 modulation/S30EA ribosomal protein, C-terminal TOPB45_1389 1d19fc6807207e313603c8e57b0cd2a3 168 Gene3D G3DSA:3.30.160.100 2 104 2.4E-27 T 13-10-2018 IPR036567 Ribosome hibernation promotion factor-like TOPB45_1389 1d19fc6807207e313603c8e57b0cd2a3 168 SUPERFAMILY SSF69754 4 101 3.27E-27 T 13-10-2018 IPR036567 Ribosome hibernation promotion factor-like TOPB45_1389 1d19fc6807207e313603c8e57b0cd2a3 168 TIGRFAM TIGR00741 yfiA: ribosomal subunit interface protein 4 97 2.3E-21 T 13-10-2018 IPR003489 Ribosome hibernation promoting factor/RaiA GO:0044238 TOPB45_1389 1d19fc6807207e313603c8e57b0cd2a3 168 Gene3D G3DSA:3.30.505.50 121 164 1.3E-5 T 13-10-2018 IPR038416 Sigma 54 modulation/S30EA ribosomal protein, C-terminal domain superfamily TOPB45_1389 1d19fc6807207e313603c8e57b0cd2a3 168 Pfam PF02482 Sigma 54 modulation protein / S30EA ribosomal protein 5 94 3.1E-22 T 13-10-2018 IPR003489 Ribosome hibernation promoting factor/RaiA GO:0044238 TOPB45_0601 8fad34d1604a97d59a110593f2fcf8b0 118 Gene3D G3DSA:3.40.1260.10 8 118 1.7E-18 T 13-10-2018 IPR027396 DsrEFH-like TOPB45_0601 8fad34d1604a97d59a110593f2fcf8b0 118 Pfam PF02635 DsrE/DsrF-like family 29 116 1.4E-8 T 13-10-2018 IPR003787 Sulphur relay, DsrE/F-like protein TOPB45_0601 8fad34d1604a97d59a110593f2fcf8b0 118 SUPERFAMILY SSF75169 8 117 1.03E-17 T 13-10-2018 IPR027396 DsrEFH-like TOPB45_0464 90e46205cdf8ce8dba2569527062e4ed 336 SUPERFAMILY SSF55326 5 150 2.09E-27 T 13-10-2018 IPR036921 PurM-like, N-terminal domain superfamily TOPB45_0464 90e46205cdf8ce8dba2569527062e4ed 336 Gene3D G3DSA:3.90.650.10 154 336 2.5E-56 T 13-10-2018 IPR036676 PurM-like, C-terminal domain superfamily TOPB45_0464 90e46205cdf8ce8dba2569527062e4ed 336 PIRSF PIRSF005644 1 336 9.0E-115 T 13-10-2018 IPR011854 Carbamoyl dehydratase HypE TOPB45_0464 90e46205cdf8ce8dba2569527062e4ed 336 TIGRFAM TIGR02124 hypE: hydrogenase expression/formation protein HypE 6 336 1.9E-129 T 13-10-2018 IPR011854 Carbamoyl dehydratase HypE TOPB45_0464 90e46205cdf8ce8dba2569527062e4ed 336 SUPERFAMILY SSF56042 155 332 2.24E-43 T 13-10-2018 IPR036676 PurM-like, C-terminal domain superfamily TOPB45_0464 90e46205cdf8ce8dba2569527062e4ed 336 Gene3D G3DSA:3.30.1330.10 9 152 1.9E-45 T 13-10-2018 IPR036921 PurM-like, N-terminal domain superfamily TOPB45_0464 90e46205cdf8ce8dba2569527062e4ed 336 Pfam PF02769 AIR synthase related protein, C-terminal domain 161 307 1.4E-25 T 13-10-2018 IPR010918 PurM-like, C-terminal domain TOPB45_0464 90e46205cdf8ce8dba2569527062e4ed 336 Pfam PF00586 AIR synthase related protein, N-terminal domain 39 149 6.1E-14 T 13-10-2018 IPR016188 PurM-like, N-terminal domain TOPB45_1601 97b5b1d38bd253983345224beb85100e 317 SUPERFAMILY SSF52518 18 306 6.2E-77 T 13-10-2018 IPR029061 Thiamin diphosphate-binding fold TOPB45_1601 97b5b1d38bd253983345224beb85100e 317 Pfam PF02775 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain 55 224 9.2E-24 T 13-10-2018 IPR011766 Thiamine pyrophosphate enzyme, C-terminal TPP-binding GO:0003824|GO:0030976 TOPB45_1601 97b5b1d38bd253983345224beb85100e 317 Gene3D G3DSA:3.40.50.970 19 104 1.9E-13 T 13-10-2018 TOPB45_1601 97b5b1d38bd253983345224beb85100e 317 Gene3D G3DSA:3.40.50.970 105 312 3.2E-65 T 13-10-2018 TOPB45_1352 5851350bd3224fcac775566d7f7d85ee 418 SMART SM01091 336 417 6.1E-22 T 13-10-2018 IPR005170 Transporter-associated domain TOPB45_1352 5851350bd3224fcac775566d7f7d85ee 418 Pfam PF01595 Domain of unknown function DUF21 7 184 4.5E-19 T 13-10-2018 IPR002550 CNNM, transmembrane domain TOPB45_1352 5851350bd3224fcac775566d7f7d85ee 418 Gene3D G3DSA:3.30.465.10 331 414 1.2E-19 T 13-10-2018 IPR016169 FAD-binding, type PCMH, subdomain 2 TOPB45_1352 5851350bd3224fcac775566d7f7d85ee 418 Gene3D G3DSA:3.10.580.10 181 330 1.3E-40 T 13-10-2018 TOPB45_1352 5851350bd3224fcac775566d7f7d85ee 418 Pfam PF03471 Transporter associated domain 337 416 5.6E-19 T 13-10-2018 IPR005170 Transporter-associated domain TOPB45_1352 5851350bd3224fcac775566d7f7d85ee 418 SUPERFAMILY SSF54631 197 336 1.89E-22 T 13-10-2018 TOPB45_1352 5851350bd3224fcac775566d7f7d85ee 418 SUPERFAMILY SSF56176 334 415 3.27E-17 T 13-10-2018 IPR036318 FAD-binding, type PCMH-like superfamily GO:0050660 TOPB45_1352 5851350bd3224fcac775566d7f7d85ee 418 Pfam PF00571 CBS domain 272 320 7.9E-6 T 13-10-2018 IPR000644 CBS domain TOPB45_0076 a42b50bbf64ccaa3ceac4160c64640fc 201 TIGRFAM TIGR00731 bL25_bact_ctc: ribosomal protein bL25, Ctc-form 6 184 1.1E-49 T 13-10-2018 IPR001021 Ribosomal protein L25, long-form GO:0003735|GO:0005840|GO:0006412|GO:0008097 TOPB45_0076 a42b50bbf64ccaa3ceac4160c64640fc 201 ProDom PD012503 RIBOSOMAL L25 50S RRNA-BINDING RNA-BINDING RIBONUCLEOPROTEIN STRESS GENERAL CTC RRNA 14 99 8.0E-11 T 13-10-2018 IPR029751 Ribosomal protein L25 GO:0003735|GO:0005840|GO:0006412|GO:0008097 TOPB45_0076 a42b50bbf64ccaa3ceac4160c64640fc 201 Pfam PF14693 Ribosomal protein TL5, C-terminal domain 105 185 3.9E-29 T 13-10-2018 IPR020057 Ribosomal protein L25, beta domain TOPB45_0076 a42b50bbf64ccaa3ceac4160c64640fc 201 SUPERFAMILY SSF50715 4 193 4.36E-55 T 13-10-2018 IPR011035 Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain superfamily GO:0006412 Reactome: R-HSA-2408517|Reactome: R-HSA-379716 TOPB45_0076 a42b50bbf64ccaa3ceac4160c64640fc 201 Hamap MF_01334 50S ribosomal protein L25 [rplY]. 4 187 28.487 T 13-10-2018 IPR001021 Ribosomal protein L25, long-form GO:0003735|GO:0005840|GO:0006412|GO:0008097 TOPB45_0076 a42b50bbf64ccaa3ceac4160c64640fc 201 Gene3D G3DSA:2.170.120.20 102 195 7.2E-31 T 13-10-2018 IPR037121 Ribosomal protein L25, C-terminal TOPB45_0076 a42b50bbf64ccaa3ceac4160c64640fc 201 Gene3D G3DSA:2.40.240.10 3 99 3.3E-25 T 13-10-2018 IPR020056 Ribosomal protein L25/Gln-tRNA synthetase, N-terminal Reactome: R-HSA-2408517|Reactome: R-HSA-379716 TOPB45_0076 a42b50bbf64ccaa3ceac4160c64640fc 201 Pfam PF01386 Ribosomal L25p family 6 96 1.8E-24 T 13-10-2018 IPR029751 Ribosomal protein L25 GO:0003735|GO:0005840|GO:0006412|GO:0008097 TOPB45_1433 f022dcff72299ac8de0d3cc918244504 862 Pfam PF08264 Anticodon-binding domain of tRNA 699 823 6.5E-27 T 13-10-2018 IPR013155 Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding GO:0004812|GO:0006418 TOPB45_1433 f022dcff72299ac8de0d3cc918244504 862 Pfam PF09334 tRNA synthetases class I (M) 36 180 1.3E-22 T 13-10-2018 IPR015413 Methionyl/Leucyl tRNA synthetase GO:0000166|GO:0004812|GO:0005524|GO:0006418 TOPB45_1433 f022dcff72299ac8de0d3cc918244504 862 TIGRFAM TIGR00396 leuS_bact: leucine--tRNA ligase 4 861 0.0 T 13-10-2018 IPR002302 Leucine-tRNA ligase GO:0000166|GO:0004823|GO:0005524|GO:0006429 KEGG: 00970+6.1.1.4|Reactome: R-HSA-379726 TOPB45_1433 f022dcff72299ac8de0d3cc918244504 862 Pfam PF00133 tRNA synthetases class I (I, L, M and V) 613 654 3.8E-8 T 13-10-2018 IPR002300 Aminoacyl-tRNA synthetase, class Ia GO:0000166|GO:0004812|GO:0005524|GO:0006418 TOPB45_1433 f022dcff72299ac8de0d3cc918244504 862 Pfam PF00133 tRNA synthetases class I (I, L, M and V) 420 577 1.8E-9 T 13-10-2018 IPR002300 Aminoacyl-tRNA synthetase, class Ia GO:0000166|GO:0004812|GO:0005524|GO:0006418 TOPB45_1433 f022dcff72299ac8de0d3cc918244504 862 Pfam PF13603 Leucyl-tRNA synthetase, Domain 2 222 406 3.5E-69 T 13-10-2018 IPR025709 Leucyl-tRNA synthetase, editing domain GO:0002161|GO:0006418 KEGG: 00970+6.1.1.4 TOPB45_1433 f022dcff72299ac8de0d3cc918244504 862 Hamap MF_00049_B Leucine--tRNA ligase [leuS]. 3 861 23.274 T 13-10-2018 IPR002302 Leucine-tRNA ligase GO:0000166|GO:0004823|GO:0005524|GO:0006429 KEGG: 00970+6.1.1.4|Reactome: R-HSA-379726 TOPB45_1433 f022dcff72299ac8de0d3cc918244504 862 ProSitePatterns PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 41 52 - T 13-10-2018 IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site GO:0000166|GO:0004812|GO:0005524|GO:0006418 TOPB45_1433 f022dcff72299ac8de0d3cc918244504 862 Gene3D G3DSA:1.10.730.10 8 793 0.0 T 13-10-2018 TOPB45_1433 f022dcff72299ac8de0d3cc918244504 862 SUPERFAMILY SSF50677 226 418 8.58E-52 T 13-10-2018 IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain GO:0002161|GO:0006418 TOPB45_1433 f022dcff72299ac8de0d3cc918244504 862 Gene3D G3DSA:3.90.740.10 227 417 0.0 T 13-10-2018 IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain GO:0002161|GO:0006418 TOPB45_1433 f022dcff72299ac8de0d3cc918244504 862 SUPERFAMILY SSF47323 657 861 2.99E-40 T 13-10-2018 IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 TOPB45_1433 f022dcff72299ac8de0d3cc918244504 862 SUPERFAMILY SSF52374 3 662 3.43E-155 T 13-10-2018 TOPB45_1433 f022dcff72299ac8de0d3cc918244504 862 PRINTS PR00985 Leucyl-tRNA synthetase signature 215 234 8.2E-47 T 13-10-2018 IPR002302 Leucine-tRNA ligase GO:0000166|GO:0004823|GO:0005524|GO:0006429 KEGG: 00970+6.1.1.4|Reactome: R-HSA-379726 TOPB45_1433 f022dcff72299ac8de0d3cc918244504 862 PRINTS PR00985 Leucyl-tRNA synthetase signature 562 572 8.2E-47 T 13-10-2018 IPR002302 Leucine-tRNA ligase GO:0000166|GO:0004823|GO:0005524|GO:0006429 KEGG: 00970+6.1.1.4|Reactome: R-HSA-379726 TOPB45_1433 f022dcff72299ac8de0d3cc918244504 862 PRINTS PR00985 Leucyl-tRNA synthetase signature 152 168 8.2E-47 T 13-10-2018 IPR002302 Leucine-tRNA ligase GO:0000166|GO:0004823|GO:0005524|GO:0006429 KEGG: 00970+6.1.1.4|Reactome: R-HSA-379726 TOPB45_1433 f022dcff72299ac8de0d3cc918244504 862 PRINTS PR00985 Leucyl-tRNA synthetase signature 126 143 8.2E-47 T 13-10-2018 IPR002302 Leucine-tRNA ligase GO:0000166|GO:0004823|GO:0005524|GO:0006429 KEGG: 00970+6.1.1.4|Reactome: R-HSA-379726 TOPB45_1433 f022dcff72299ac8de0d3cc918244504 862 PRINTS PR00985 Leucyl-tRNA synthetase signature 184 197 8.2E-47 T 13-10-2018 IPR002302 Leucine-tRNA ligase GO:0000166|GO:0004823|GO:0005524|GO:0006429 KEGG: 00970+6.1.1.4|Reactome: R-HSA-379726 TOPB45_1433 f022dcff72299ac8de0d3cc918244504 862 PRINTS PR00985 Leucyl-tRNA synthetase signature 491 509 8.2E-47 T 13-10-2018 IPR002302 Leucine-tRNA ligase GO:0000166|GO:0004823|GO:0005524|GO:0006429 KEGG: 00970+6.1.1.4|Reactome: R-HSA-379726 TOPB45_1433 f022dcff72299ac8de0d3cc918244504 862 PRINTS PR00985 Leucyl-tRNA synthetase signature 529 551 8.2E-47 T 13-10-2018 IPR002302 Leucine-tRNA ligase GO:0000166|GO:0004823|GO:0005524|GO:0006429 KEGG: 00970+6.1.1.4|Reactome: R-HSA-379726 TOPB45_1433 f022dcff72299ac8de0d3cc918244504 862 Gene3D G3DSA:3.40.50.620 32 571 0.0 T 13-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TOPB45_1433 f022dcff72299ac8de0d3cc918244504 862 Gene3D G3DSA:3.10.330.110 572 623 0.0 T 13-10-2018 TOPB45_1433 f022dcff72299ac8de0d3cc918244504 862 Gene3D G3DSA:3.10.20.590 802 862 1.8E-22 T 13-10-2018 TOPB45_1146 26490ad342eb0673f16c5a4f3768ab59 304 Pfam PF01545 Cation efflux family 17 210 2.7E-41 T 13-10-2018 IPR002524 Cation efflux protein GO:0006812|GO:0008324|GO:0016021|GO:0055085 TOPB45_1146 26490ad342eb0673f16c5a4f3768ab59 304 Pfam PF16916 Dimerisation domain of Zinc Transporter 217 299 1.5E-22 T 13-10-2018 IPR027470 Cation efflux protein, cytoplasmic domain TOPB45_1146 26490ad342eb0673f16c5a4f3768ab59 304 TIGRFAM TIGR01297 CDF: cation diffusion facilitator family transporter 14 300 2.6E-64 T 13-10-2018 IPR002524 Cation efflux protein GO:0006812|GO:0008324|GO:0016021|GO:0055085 TOPB45_1146 26490ad342eb0673f16c5a4f3768ab59 304 Gene3D G3DSA:1.20.1510.10 12 209 3.8E-50 T 13-10-2018 IPR027469 Cation efflux transmembrane domain superfamily TOPB45_1146 26490ad342eb0673f16c5a4f3768ab59 304 Gene3D G3DSA:3.30.70.1350 210 304 1.4E-31 T 13-10-2018 IPR036837 Cation efflux protein, cytoplasmic domain superfamily Reactome: R-HSA-435368 TOPB45_1146 26490ad342eb0673f16c5a4f3768ab59 304 SUPERFAMILY SSF161111 11 211 1.31E-47 T 13-10-2018 IPR027469 Cation efflux transmembrane domain superfamily TOPB45_1146 26490ad342eb0673f16c5a4f3768ab59 304 SUPERFAMILY SSF160240 237 299 2.22E-19 T 13-10-2018 IPR036837 Cation efflux protein, cytoplasmic domain superfamily Reactome: R-HSA-435368 TOPB45_1333 f16b57e31073f7d2487fc2347e6c1269 232 PRINTS PR01302 Type III secretion system inner membrane P protein family signature 33 52 2.8E-66 T 13-10-2018 IPR005838 Type III secretion system inner membrane P protein GO:0009306|GO:0016020 TOPB45_1333 f16b57e31073f7d2487fc2347e6c1269 232 PRINTS PR01302 Type III secretion system inner membrane P protein family signature 205 230 2.8E-66 T 13-10-2018 IPR005838 Type III secretion system inner membrane P protein GO:0009306|GO:0016020 TOPB45_1333 f16b57e31073f7d2487fc2347e6c1269 232 PRINTS PR01302 Type III secretion system inner membrane P protein family signature 52 72 2.8E-66 T 13-10-2018 IPR005838 Type III secretion system inner membrane P protein GO:0009306|GO:0016020 TOPB45_1333 f16b57e31073f7d2487fc2347e6c1269 232 PRINTS PR01302 Type III secretion system inner membrane P protein family signature 181 202 2.8E-66 T 13-10-2018 IPR005838 Type III secretion system inner membrane P protein GO:0009306|GO:0016020 TOPB45_1333 f16b57e31073f7d2487fc2347e6c1269 232 PRINTS PR01302 Type III secretion system inner membrane P protein family signature 160 180 2.8E-66 T 13-10-2018 IPR005838 Type III secretion system inner membrane P protein GO:0009306|GO:0016020 TOPB45_1333 f16b57e31073f7d2487fc2347e6c1269 232 PRINTS PR01302 Type III secretion system inner membrane P protein family signature 72 91 2.8E-66 T 13-10-2018 IPR005838 Type III secretion system inner membrane P protein GO:0009306|GO:0016020 TOPB45_1333 f16b57e31073f7d2487fc2347e6c1269 232 TIGRFAM TIGR01103 fliP: flagellar biosynthetic protein FliP 35 231 6.3E-87 T 13-10-2018 IPR005837 Flagellar transport protein FliP GO:0009306|GO:0016020 TOPB45_1333 f16b57e31073f7d2487fc2347e6c1269 232 ProSitePatterns PS01061 Flagella transport protein fliP family signature 2. 208 220 - T 13-10-2018 IPR005838 Type III secretion system inner membrane P protein GO:0009306|GO:0016020 TOPB45_1333 f16b57e31073f7d2487fc2347e6c1269 232 ProSitePatterns PS01060 Flagella transport protein fliP family signature 1. 160 175 - T 13-10-2018 IPR005838 Type III secretion system inner membrane P protein GO:0009306|GO:0016020 TOPB45_1333 f16b57e31073f7d2487fc2347e6c1269 232 Pfam PF00813 FliP family 35 227 3.0E-81 T 13-10-2018 IPR005838 Type III secretion system inner membrane P protein GO:0009306|GO:0016020 TOPB45_1333 f16b57e31073f7d2487fc2347e6c1269 232 PRINTS PR00951 Flagellar biosynthetic protein FliP signature 221 231 2.7E-24 T 13-10-2018 IPR005837 Flagellar transport protein FliP GO:0009306|GO:0016020 TOPB45_1333 f16b57e31073f7d2487fc2347e6c1269 232 PRINTS PR00951 Flagellar biosynthetic protein FliP signature 103 117 2.7E-24 T 13-10-2018 IPR005837 Flagellar transport protein FliP GO:0009306|GO:0016020 TOPB45_1333 f16b57e31073f7d2487fc2347e6c1269 232 PRINTS PR00951 Flagellar biosynthetic protein FliP signature 153 165 2.7E-24 T 13-10-2018 IPR005837 Flagellar transport protein FliP GO:0009306|GO:0016020 TOPB45_1333 f16b57e31073f7d2487fc2347e6c1269 232 PRINTS PR00951 Flagellar biosynthetic protein FliP signature 31 40 2.7E-24 T 13-10-2018 IPR005837 Flagellar transport protein FliP GO:0009306|GO:0016020 TOPB45_1333 f16b57e31073f7d2487fc2347e6c1269 232 PRINTS PR00951 Flagellar biosynthetic protein FliP signature 131 143 2.7E-24 T 13-10-2018 IPR005837 Flagellar transport protein FliP GO:0009306|GO:0016020 TOPB45_1333 f16b57e31073f7d2487fc2347e6c1269 232 PRINTS PR00951 Flagellar biosynthetic protein FliP signature 91 103 2.7E-24 T 13-10-2018 IPR005837 Flagellar transport protein FliP GO:0009306|GO:0016020 TOPB45_0228 edbdb1d412daed6effc8cab81ce1a5f6 465 TIGRFAM TIGR01845 outer_NodT: efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family 10 464 8.5E-106 T 13-10-2018 IPR010131 RND efflux system, outer membrane lipoprotein, NodT GO:0016020|GO:0022857|GO:0055085 TOPB45_0228 edbdb1d412daed6effc8cab81ce1a5f6 465 SUPERFAMILY SSF56954 1 464 1.57E-103 T 13-10-2018 TOPB45_0228 edbdb1d412daed6effc8cab81ce1a5f6 465 Gene3D G3DSA:2.20.200.10 99 349 3.4E-116 T 13-10-2018 TOPB45_0228 edbdb1d412daed6effc8cab81ce1a5f6 465 Pfam PF02321 Outer membrane efflux protein 63 252 1.1E-27 T 13-10-2018 IPR003423 Outer membrane efflux protein GO:0015562|GO:0055085 TOPB45_0228 edbdb1d412daed6effc8cab81ce1a5f6 465 Pfam PF02321 Outer membrane efflux protein 279 455 2.3E-25 T 13-10-2018 IPR003423 Outer membrane efflux protein GO:0015562|GO:0055085 TOPB45_0228 edbdb1d412daed6effc8cab81ce1a5f6 465 Gene3D G3DSA:1.20.1600.10 54 464 3.4E-116 T 13-10-2018 TOPB45_1050 f1c527a25462adfdb5a90d20554c3248 143 ProSitePatterns PS00678 Trp-Asp (WD) repeats signature. 84 98 - T 13-10-2018 IPR019775 WD40 repeat, conserved site TOPB45_1050 f1c527a25462adfdb5a90d20554c3248 143 SUPERFAMILY SSF50978 1 118 2.38E-45 T 13-10-2018 IPR036322 WD40-repeat-containing domain superfamily GO:0005515 TOPB45_1050 f1c527a25462adfdb5a90d20554c3248 143 PRINTS PR00320 G protein beta WD-40 repeat signature 84 98 2.8E-5 T 13-10-2018 IPR020472 G-protein beta WD-40 repeat TOPB45_1050 f1c527a25462adfdb5a90d20554c3248 143 PRINTS PR00320 G protein beta WD-40 repeat signature 42 56 2.8E-5 T 13-10-2018 IPR020472 G-protein beta WD-40 repeat TOPB45_1050 f1c527a25462adfdb5a90d20554c3248 143 Gene3D G3DSA:2.130.10.10 1 141 8.7E-50 T 13-10-2018 IPR015943 WD40/YVTN repeat-like-containing domain superfamily GO:0005515 TOPB45_1050 f1c527a25462adfdb5a90d20554c3248 143 Pfam PF00400 WD domain, G-beta repeat 60 97 4.6E-11 T 13-10-2018 IPR001680 WD40 repeat GO:0005515 TOPB45_1050 f1c527a25462adfdb5a90d20554c3248 143 Pfam PF00400 WD domain, G-beta repeat 18 55 5.2E-12 T 13-10-2018 IPR001680 WD40 repeat GO:0005515 TOPB45_1050 f1c527a25462adfdb5a90d20554c3248 143 SMART SM00320 16 55 2.4E-12 T 13-10-2018 IPR001680 WD40 repeat GO:0005515 TOPB45_1050 f1c527a25462adfdb5a90d20554c3248 143 SMART SM00320 58 97 3.4E-13 T 13-10-2018 IPR001680 WD40 repeat GO:0005515 TOPB45_1050 f1c527a25462adfdb5a90d20554c3248 143 ProSitePatterns PS00678 Trp-Asp (WD) repeats signature. 42 56 - T 13-10-2018 IPR019775 WD40 repeat, conserved site TOPB45_0850 7a1a174970d3a56731b406aa480689c8 407 Gene3D G3DSA:3.40.720.10 16 393 2.3E-99 T 13-10-2018 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824 TOPB45_0850 7a1a174970d3a56731b406aa480689c8 407 SUPERFAMILY SSF53649 13 373 1.44E-34 T 13-10-2018 IPR017850 Alkaline-phosphatase-like, core domain superfamily GO:0003824 TOPB45_0850 7a1a174970d3a56731b406aa480689c8 407 Hamap MF_01402_B 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [apgM]. 13 398 53.82 T 13-10-2018 IPR023665 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, prokaryotes GO:0046537 KEGG: 00010+5.4.2.12|KEGG: 00260+5.4.2.12|KEGG: 00680+5.4.2.12|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TOPB45_0850 7a1a174970d3a56731b406aa480689c8 407 Gene3D G3DSA:3.30.70.2130 88 236 2.3E-99 T 13-10-2018 TOPB45_0850 7a1a174970d3a56731b406aa480689c8 407 Pfam PF01676 Metalloenzyme superfamily 14 394 1.3E-37 T 13-10-2018 IPR006124 Metalloenzyme GO:0003824|GO:0046872 TOPB45_0850 7a1a174970d3a56731b406aa480689c8 407 Pfam PF10143 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 47 223 9.1E-45 T 13-10-2018 IPR004456 2,3-bisphosphoglycerate-independent phosphoglycerate mutase GO:0003824|GO:0046537 KEGG: 00010+5.4.2.12|KEGG: 00260+5.4.2.12|KEGG: 00680+5.4.2.12|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TOPB45_0850 7a1a174970d3a56731b406aa480689c8 407 PIRSF PIRSF006392 10 403 1.2E-122 T 13-10-2018 IPR004456 2,3-bisphosphoglycerate-independent phosphoglycerate mutase GO:0003824|GO:0046537 KEGG: 00010+5.4.2.12|KEGG: 00260+5.4.2.12|KEGG: 00680+5.4.2.12|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TOPB45_0850 7a1a174970d3a56731b406aa480689c8 407 TIGRFAM TIGR00306 apgM: phosphoglycerate mutase (2,3-diphosphoglycerate-independent), archaeal form 16 396 1.6E-86 T 13-10-2018 IPR004456 2,3-bisphosphoglycerate-independent phosphoglycerate mutase GO:0003824|GO:0046537 KEGG: 00010+5.4.2.12|KEGG: 00260+5.4.2.12|KEGG: 00680+5.4.2.12|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 TOPB45_0289 cb1d1bc1a9c2e53abeed0450d8007147 378 Gene3D G3DSA:1.10.287.470 81 101 1.3E-9 T 13-10-2018 TOPB45_0289 cb1d1bc1a9c2e53abeed0450d8007147 378 Gene3D G3DSA:2.40.50.100 46 80 1.3E-9 T 13-10-2018 TOPB45_0289 cb1d1bc1a9c2e53abeed0450d8007147 378 SUPERFAMILY SSF111369 226 312 3.4E-6 T 13-10-2018 TOPB45_0289 cb1d1bc1a9c2e53abeed0450d8007147 378 Gene3D G3DSA:2.40.30.170 264 377 4.1E-30 T 13-10-2018 TOPB45_0289 cb1d1bc1a9c2e53abeed0450d8007147 378 Gene3D G3DSA:1.10.287.470 135 199 9.9E-6 T 13-10-2018 TOPB45_0289 cb1d1bc1a9c2e53abeed0450d8007147 378 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion 186 326 2.8E-16 T 13-10-2018 IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain TOPB45_0289 cb1d1bc1a9c2e53abeed0450d8007147 378 Pfam PF13533 Biotin-lipoyl like 53 96 1.3E-9 T 13-10-2018 IPR039562 Membrane fusion protein, biotin-lipoyl like domain TOPB45_0289 cb1d1bc1a9c2e53abeed0450d8007147 378 PRINTS PR01490 Gram-negative bacterial RTX secretion protein D signature 59 79 8.1E-11 T 13-10-2018 IPR003997 RTX secretion protein D, Gram-negative bacteria GO:0009306|GO:0016020 TOPB45_0289 cb1d1bc1a9c2e53abeed0450d8007147 378 PRINTS PR01490 Gram-negative bacterial RTX secretion protein D signature 261 282 8.1E-11 T 13-10-2018 IPR003997 RTX secretion protein D, Gram-negative bacteria GO:0009306|GO:0016020 TOPB45_0289 cb1d1bc1a9c2e53abeed0450d8007147 378 PRINTS PR01490 Gram-negative bacterial RTX secretion protein D signature 364 378 8.1E-11 T 13-10-2018 IPR003997 RTX secretion protein D, Gram-negative bacteria GO:0009306|GO:0016020 TOPB45_0289 cb1d1bc1a9c2e53abeed0450d8007147 378 PRINTS PR01490 Gram-negative bacterial RTX secretion protein D signature 293 317 8.1E-11 T 13-10-2018 IPR003997 RTX secretion protein D, Gram-negative bacteria GO:0009306|GO:0016020 TOPB45_0631 f75e9e9b78d0a72511fa0285079f398b 242 Gene3D G3DSA:3.20.20.70 1 241 6.9E-80 T 13-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 TOPB45_0631 f75e9e9b78d0a72511fa0285079f398b 242 SUPERFAMILY SSF51366 2 238 5.65E-67 T 13-10-2018 IPR011060 Ribulose-phosphate binding barrel GO:0003824 TOPB45_0631 f75e9e9b78d0a72511fa0285079f398b 242 Hamap MF_01014 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase [hisA]. 2 238 33.082 T 13-10-2018 IPR023016 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase GO:0000105|GO:0003949 KEGG: 00340+5.3.1.16 TOPB45_0631 f75e9e9b78d0a72511fa0285079f398b 242 TIGRFAM TIGR00007 TIGR00007: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase 3 234 3.1E-77 T 13-10-2018 IPR006063 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA GO:0000105|GO:0003949 KEGG: 00340+5.3.1.16 TOPB45_0631 f75e9e9b78d0a72511fa0285079f398b 242 Pfam PF00977 Histidine biosynthesis protein 3 230 3.3E-71 T 13-10-2018 IPR006062 Histidine biosynthesis GO:0000105 TOPB45_1158 5938bb18cc8268859ccff5ce9d984c54 250 SMART SM00382 29 226 2.2E-5 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_1158 5938bb18cc8268859ccff5ce9d984c54 250 Pfam PF00005 ABC transporter 20 161 7.8E-24 T 13-10-2018 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TOPB45_1158 5938bb18cc8268859ccff5ce9d984c54 250 SUPERFAMILY SSF52540 4 235 9.71E-42 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1158 5938bb18cc8268859ccff5ce9d984c54 250 Gene3D G3DSA:3.40.50.300 3 242 2.2E-50 T 13-10-2018 TOPB45_0749 77e3e4a8755ca6c3a260c20566e71a02 157 ProSitePatterns PS00052 Ribosomal protein S7 signature. 20 46 - T 13-10-2018 IPR020606 Ribosomal protein S7, conserved site GO:0003723|GO:0003735|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0749 77e3e4a8755ca6c3a260c20566e71a02 157 PIRSF PIRSF002122 4 157 1.6E-61 T 13-10-2018 IPR000235 Ribosomal protein S5/S7 GO:0006412 TOPB45_0749 77e3e4a8755ca6c3a260c20566e71a02 157 Gene3D G3DSA:1.10.455.10 2 157 2.0E-65 T 13-10-2018 IPR036823 Ribosomal protein S7 domain superfamily TOPB45_0749 77e3e4a8755ca6c3a260c20566e71a02 157 Pfam PF00177 Ribosomal protein S7p/S5e 1 150 6.6E-67 T 13-10-2018 IPR023798 Ribosomal protein S7 domain TOPB45_0749 77e3e4a8755ca6c3a260c20566e71a02 157 SUPERFAMILY SSF47973 1 150 1.44E-60 T 13-10-2018 IPR036823 Ribosomal protein S7 domain superfamily TOPB45_0749 77e3e4a8755ca6c3a260c20566e71a02 157 Hamap MF_00480_B 30S ribosomal protein S7 [rpsG]. 1 157 36.178 T 13-10-2018 IPR005717 Ribosomal protein S7, bacterial/organellar-type GO:0003735|GO:0006412|GO:0015935 TOPB45_0749 77e3e4a8755ca6c3a260c20566e71a02 157 TIGRFAM TIGR01029 rpsG_bact: ribosomal protein uS7 3 157 8.3E-69 T 13-10-2018 IPR005717 Ribosomal protein S7, bacterial/organellar-type GO:0003735|GO:0006412|GO:0015935 TOPB45_1503 71d244740e40a1665f819dc78f067e2d 274 Gene3D G3DSA:3.40.50.720 101 231 2.2E-89 T 13-10-2018 TOPB45_1503 71d244740e40a1665f819dc78f067e2d 274 Pfam PF08501 Shikimate dehydrogenase substrate binding domain 7 89 8.3E-31 T 13-10-2018 IPR013708 Shikimate dehydrogenase substrate binding, N-terminal GO:0004764|GO:0055114 KEGG: 00400+1.1.1.25|MetaCyc: PWY-6163 TOPB45_1503 71d244740e40a1665f819dc78f067e2d 274 TIGRFAM TIGR00507 aroE: shikimate dehydrogenase 3 263 2.9E-79 T 13-10-2018 IPR011342 Shikimate dehydrogenase GO:0004764|GO:0019632|GO:0050661|GO:0055114 KEGG: 00400+1.1.1.25|MetaCyc: PWY-6163 TOPB45_1503 71d244740e40a1665f819dc78f067e2d 274 Hamap MF_00222 Shikimate dehydrogenase (NADP(+)) [aroE]. 2 263 35.36 T 13-10-2018 IPR022893 Shikimate dehydrogenase family GO:0004764|GO:0055114 KEGG: 00400+1.1.1.25|MetaCyc: PWY-6163 TOPB45_1503 71d244740e40a1665f819dc78f067e2d 274 SUPERFAMILY SSF51735 102 263 1.1E-40 T 13-10-2018 IPR036291 NAD(P)-binding domain superfamily TOPB45_1503 71d244740e40a1665f819dc78f067e2d 274 SUPERFAMILY SSF53223 3 101 8.06E-33 T 13-10-2018 TOPB45_1503 71d244740e40a1665f819dc78f067e2d 274 Pfam PF01488 Shikimate / quinate 5-dehydrogenase 116 186 6.1E-13 T 13-10-2018 IPR006151 Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase TOPB45_1503 71d244740e40a1665f819dc78f067e2d 274 Gene3D G3DSA:3.40.50.10860 5 248 2.2E-89 T 13-10-2018 TOPB45_0827 5602d971d62386dee049489557c6a744 287 Gene3D G3DSA:3.40.800.10 6 286 4.5E-77 T 13-10-2018 TOPB45_0827 5602d971d62386dee049489557c6a744 287 Pfam PF00491 Arginase family 15 276 1.1E-69 T 13-10-2018 IPR006035 Ureohydrolase GO:0046872 TOPB45_0827 5602d971d62386dee049489557c6a744 287 TIGRFAM TIGR01230 agmatinase: agmatinase 11 276 2.1E-70 T 13-10-2018 IPR005925 Agmatinase-related KEGG: 00330+3.5.3.11|MetaCyc: PWY-40|MetaCyc: PWY-6305|Reactome: R-HSA-351143 TOPB45_0827 5602d971d62386dee049489557c6a744 287 PIRSF PIRSF036979 4 284 2.8E-70 T 13-10-2018 IPR006035 Ureohydrolase GO:0046872 TOPB45_0827 5602d971d62386dee049489557c6a744 287 SUPERFAMILY SSF52768 8 280 1.1E-72 T 13-10-2018 IPR023696 Ureohydrolase domain superfamily TOPB45_0827 5602d971d62386dee049489557c6a744 287 ProSitePatterns PS01053 Arginase family signature. 209 230 - T 13-10-2018 IPR020855 Ureohydrolase, manganese-binding site GO:0016813|GO:0046872 TOPB45_0950 5d6b1efa9dac11c4f717c690e10183fe 396 TIGRFAM TIGR04336 AmmeMemoSam_B: AmmeMemoRadiSam system protein B 112 364 4.8E-19 T 13-10-2018 TOPB45_0950 5d6b1efa9dac11c4f717c690e10183fe 396 Gene3D G3DSA:3.40.830.10 110 393 7.7E-41 T 13-10-2018 TOPB45_0950 5d6b1efa9dac11c4f717c690e10183fe 396 Pfam PF01875 Memo-like protein 114 375 3.7E-33 T 13-10-2018 IPR002737 MEMO1 family Reactome: R-HSA-6785631 TOPB45_1593 60711b51ea28319d03eee902f77a8834 107 Pfam PF05164 Cell division protein ZapA 8 85 2.7E-7 T 13-10-2018 IPR007838 Cell division protein ZapA-like TOPB45_1593 60711b51ea28319d03eee902f77a8834 107 SUPERFAMILY SSF102829 7 91 4.05E-6 T 13-10-2018 IPR036192 Cell division protein ZapA-like superfamily TOPB45_1152 6745f7dda90f8ad498faa5e0785acedc 340 SUPERFAMILY SSF51735 4 159 7.9E-50 T 13-10-2018 IPR036291 NAD(P)-binding domain superfamily TOPB45_1152 6745f7dda90f8ad498faa5e0785acedc 340 Pfam PF01118 Semialdehyde dehydrogenase, NAD binding domain 5 119 9.1E-32 T 13-10-2018 IPR000534 Semialdehyde dehydrogenase, NAD-binding GO:0016620|GO:0051287|GO:0055114 TOPB45_1152 6745f7dda90f8ad498faa5e0785acedc 340 PIRSF PIRSF000148 3 340 1.4E-131 T 13-10-2018 TOPB45_1152 6745f7dda90f8ad498faa5e0785acedc 340 TIGRFAM TIGR01296 asd_B: aspartate-semialdehyde dehydrogenase 5 338 4.0E-149 T 13-10-2018 IPR005986 Aspartate-semialdehyde dehydrogenase, beta-type GO:0004073|GO:0009086|GO:0009088|GO:0009089|GO:0009097|GO:0050661|GO:0055114 KEGG: 00260+1.2.1.11|KEGG: 00261+1.2.1.11|KEGG: 00270+1.2.1.11|KEGG: 00300+1.2.1.11|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|MetaCyc: PWY-6160|MetaCyc: PWY-6559|MetaCyc: PWY-6562|MetaCyc: PWY-7153|MetaCyc: PWY-7977 TOPB45_1152 6745f7dda90f8ad498faa5e0785acedc 340 Gene3D G3DSA:3.40.50.720 6 333 3.7E-142 T 13-10-2018 TOPB45_1152 6745f7dda90f8ad498faa5e0785acedc 340 Hamap MF_02121 Aspartate-semialdehyde dehydrogenase [asd]. 3 336 37.503 T 13-10-2018 IPR012080 Aspartate-semialdehyde dehydrogenase GO:0004073|GO:0009086|GO:0009088|GO:0009089|GO:0009097|GO:0050661 KEGG: 00260+1.2.1.11|KEGG: 00261+1.2.1.11|KEGG: 00270+1.2.1.11|KEGG: 00300+1.2.1.11|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|MetaCyc: PWY-6160|MetaCyc: PWY-6559|MetaCyc: PWY-6562|MetaCyc: PWY-7153|MetaCyc: PWY-7977 TOPB45_1152 6745f7dda90f8ad498faa5e0785acedc 340 SUPERFAMILY SSF55347 131 323 9.17E-77 T 13-10-2018 TOPB45_1152 6745f7dda90f8ad498faa5e0785acedc 340 Pfam PF02774 Semialdehyde dehydrogenase, dimerisation domain 141 322 2.7E-56 T 13-10-2018 IPR012280 Semialdehyde dehydrogenase, dimerisation domain GO:0005737|GO:0008652|GO:0016620|GO:0046983 KEGG: 00220+1.2.1.38|MetaCyc: PWY-5154|MetaCyc: PWY-7400 TOPB45_1152 6745f7dda90f8ad498faa5e0785acedc 340 SMART SM00859 5 121 5.0E-42 T 13-10-2018 IPR000534 Semialdehyde dehydrogenase, NAD-binding GO:0016620|GO:0051287|GO:0055114 TOPB45_1152 6745f7dda90f8ad498faa5e0785acedc 340 Gene3D G3DSA:3.30.360.10 130 319 3.7E-142 T 13-10-2018 TOPB45_1025 6a6a4404d0b4b41326ac464795ad5b4e 306 SUPERFAMILY SSF102114 7 266 8.37E-51 T 13-10-2018 TOPB45_1025 6a6a4404d0b4b41326ac464795ad5b4e 306 TIGRFAM TIGR01212 TIGR01212: radical SAM protein, TIGR01212 family 6 305 4.0E-110 T 13-10-2018 IPR005911 Protein YhcC-like GO:0051536 TOPB45_1025 6a6a4404d0b4b41326ac464795ad5b4e 306 Pfam PF16199 Radical_SAM C-terminal domain 211 289 1.7E-24 T 13-10-2018 IPR032432 Radical SAM, C-terminal extension Reactome: R-HSA-3214847 TOPB45_1025 6a6a4404d0b4b41326ac464795ad5b4e 306 Gene3D G3DSA:3.80.30.20 42 253 1.7E-19 T 13-10-2018 IPR023404 Radical SAM, alpha/beta horseshoe TOPB45_1025 6a6a4404d0b4b41326ac464795ad5b4e 306 Pfam PF04055 Radical SAM superfamily 44 204 1.5E-17 T 13-10-2018 IPR007197 Radical SAM GO:0003824|GO:0051536 TOPB45_1025 6a6a4404d0b4b41326ac464795ad5b4e 306 SMART SM00729 23 250 1.9E-44 T 13-10-2018 IPR006638 Elp3/MiaB/NifB GO:0003824|GO:0051536 TOPB45_1048 ef595ade84658bc11707b6c0724a5188 1124 Gene3D G3DSA:3.40.50.300 650 859 3.7E-32 T 13-10-2018 TOPB45_1048 ef595ade84658bc11707b6c0724a5188 1124 Pfam PF00271 Helicase conserved C-terminal domain 729 836 1.4E-18 T 13-10-2018 IPR001650 Helicase, C-terminal TOPB45_1048 ef595ade84658bc11707b6c0724a5188 1124 Pfam PF00176 SNF2 family N-terminal domain 355 538 4.1E-12 T 13-10-2018 IPR000330 SNF2-related, N-terminal domain GO:0005524 TOPB45_1048 ef595ade84658bc11707b6c0724a5188 1124 SMART SM00490 748 836 2.5E-16 T 13-10-2018 IPR001650 Helicase, C-terminal TOPB45_1048 ef595ade84658bc11707b6c0724a5188 1124 Gene3D G3DSA:3.40.50.10810 333 514 1.1E-13 T 13-10-2018 IPR038718 SNF2-like, N-terminal domain superfamily TOPB45_1048 ef595ade84658bc11707b6c0724a5188 1124 Pfam PF13091 PLD-like domain 20 197 1.7E-10 T 13-10-2018 IPR025202 Phospholipase D-like domain Reactome: R-HSA-1483148|Reactome: R-HSA-1483166 TOPB45_1048 ef595ade84658bc11707b6c0724a5188 1124 Gene3D G3DSA:3.40.50.10810 235 332 1.3E-5 T 13-10-2018 IPR038718 SNF2-like, N-terminal domain superfamily TOPB45_1048 ef595ade84658bc11707b6c0724a5188 1124 SUPERFAMILY SSF52540 245 497 3.01E-29 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1048 ef595ade84658bc11707b6c0724a5188 1124 SMART SM00487 257 428 1.2E-12 T 13-10-2018 IPR014001 Helicase superfamily 1/2, ATP-binding domain TOPB45_1048 ef595ade84658bc11707b6c0724a5188 1124 Gene3D G3DSA:3.30.870.10 4 222 3.9E-17 T 13-10-2018 TOPB45_1048 ef595ade84658bc11707b6c0724a5188 1124 SUPERFAMILY SSF52540 356 885 7.04E-38 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1331 8c4bf08133adda0eee72cf48f87fce7d 254 Pfam PF01311 Bacterial export proteins, family 1 12 241 2.7E-46 T 13-10-2018 IPR002010 Type III secretion system inner membrane R protein GO:0006605|GO:0016020 TOPB45_1331 8c4bf08133adda0eee72cf48f87fce7d 254 PRINTS PR00953 Type III secretion system inner membrane R protein family signature 178 200 4.4E-12 T 13-10-2018 IPR002010 Type III secretion system inner membrane R protein GO:0006605|GO:0016020 TOPB45_1331 8c4bf08133adda0eee72cf48f87fce7d 254 PRINTS PR00953 Type III secretion system inner membrane R protein family signature 20 41 4.4E-12 T 13-10-2018 IPR002010 Type III secretion system inner membrane R protein GO:0006605|GO:0016020 TOPB45_1331 8c4bf08133adda0eee72cf48f87fce7d 254 PRINTS PR00953 Type III secretion system inner membrane R protein family signature 200 219 4.4E-12 T 13-10-2018 IPR002010 Type III secretion system inner membrane R protein GO:0006605|GO:0016020 TOPB45_1173 5cc852f3416d63a840457fb022017d29 248 SMART SM00967 4 82 8.0E-11 T 13-10-2018 IPR013123 RNA 2-O ribose methyltransferase, substrate binding GO:0008168 Reactome: R-HSA-6793080 TOPB45_1173 5cc852f3416d63a840457fb022017d29 248 Pfam PF00588 SpoU rRNA Methylase family 99 238 5.4E-41 T 13-10-2018 IPR001537 tRNA/rRNA methyltransferase, SpoU type GO:0003723|GO:0006396|GO:0008173 TOPB45_1173 5cc852f3416d63a840457fb022017d29 248 SUPERFAMILY SSF75217 71 246 8.5E-49 T 13-10-2018 IPR029028 Alpha/beta knot methyltransferases TOPB45_1173 5cc852f3416d63a840457fb022017d29 248 SUPERFAMILY SSF55315 3 78 1.41E-11 T 13-10-2018 IPR029064 50S ribosomal protein L30e-like TOPB45_1173 5cc852f3416d63a840457fb022017d29 248 Gene3D G3DSA:3.30.1330.30 1 77 1.3E-10 T 13-10-2018 IPR029064 50S ribosomal protein L30e-like TOPB45_1173 5cc852f3416d63a840457fb022017d29 248 Pfam PF08032 RNA 2'-O ribose methyltransferase substrate binding 5 79 4.0E-14 T 13-10-2018 IPR013123 RNA 2-O ribose methyltransferase, substrate binding GO:0008168 Reactome: R-HSA-6793080 TOPB45_1173 5cc852f3416d63a840457fb022017d29 248 TIGRFAM TIGR00186 rRNA_methyl_3: RNA methyltransferase, TrmH family, group 3 1 245 1.8E-71 T 13-10-2018 IPR004441 RNA methyltransferase TrmH family GO:0006396|GO:0008173 Reactome: R-HSA-6793080 TOPB45_1173 5cc852f3416d63a840457fb022017d29 248 Gene3D G3DSA:3.40.1280.10 80 246 1.9E-56 T 13-10-2018 IPR029026 tRNA (guanine-N1-)-methyltransferase, N-terminal TOPB45_0058 e27a44993eccd1ec9e002cb425cfc657 136 TIGRFAM TIGR01395 FlgC: flagellar basal-body rod protein FlgC 7 136 7.9E-47 T 13-10-2018 IPR006299 Flagellar basal-body rod protein FlgC GO:0030694|GO:0071973 TOPB45_0058 e27a44993eccd1ec9e002cb425cfc657 136 Pfam PF06429 Flagellar basal body rod FlgEFG protein C-terminal 86 133 5.4E-9 T 13-10-2018 IPR010930 Flagellar basal-body/hook protein, C-terminal domain TOPB45_0314 7c7ced6c05a9a556275e61ac871670fa 209 Gene3D G3DSA:3.40.50.360 1 188 1.8E-42 T 13-10-2018 IPR029039 Flavoprotein-like superfamily TOPB45_0314 7c7ced6c05a9a556275e61ac871670fa 209 SUPERFAMILY SSF52218 1 187 1.33E-33 T 13-10-2018 IPR029039 Flavoprotein-like superfamily TOPB45_0314 7c7ced6c05a9a556275e61ac871670fa 209 Pfam PF03358 NADPH-dependent FMN reductase 1 132 7.7E-21 T 13-10-2018 IPR005025 NADPH-dependent FMN reductase-like GO:0016491 TOPB45_0502 646fe2bd4c2893af043ef504a5d864fd 147 SMART SM00028 71 104 2.3E-8 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_0502 646fe2bd4c2893af043ef504a5d864fd 147 SMART SM00028 3 36 9.3 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_0502 646fe2bd4c2893af043ef504a5d864fd 147 SMART SM00028 37 70 0.0028 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_0502 646fe2bd4c2893af043ef504a5d864fd 147 Pfam PF13181 Tetratricopeptide repeat 15 36 0.0042 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_0502 646fe2bd4c2893af043ef504a5d864fd 147 Pfam PF13181 Tetratricopeptide repeat 38 70 3.9E-5 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_0502 646fe2bd4c2893af043ef504a5d864fd 147 Gene3D G3DSA:1.25.40.10 10 70 1.5E-15 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_0502 646fe2bd4c2893af043ef504a5d864fd 147 SUPERFAMILY SSF48452 3 137 1.04E-31 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_0502 646fe2bd4c2893af043ef504a5d864fd 147 Pfam PF00515 Tetratricopeptide repeat 71 104 5.4E-10 T 13-10-2018 IPR001440 Tetratricopeptide repeat 1 GO:0005515 TOPB45_0502 646fe2bd4c2893af043ef504a5d864fd 147 Gene3D G3DSA:1.25.40.10 71 146 4.5E-15 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_1133 f850f5102c5e49cd5f42908acac8d866 431 Pfam PF05140 ResB-like family 12 270 1.1E-67 T 13-10-2018 IPR007816 ResB-like domain TOPB45_1133 f850f5102c5e49cd5f42908acac8d866 431 Pfam PF05140 ResB-like family 342 417 1.9E-11 T 13-10-2018 IPR007816 ResB-like domain TOPB45_0516 f9685a83487fd570723a6bbd0904a9b5 264 SUPERFAMILY SSF56059 69 248 3.07E-23 T 13-10-2018 TOPB45_0516 f9685a83487fd570723a6bbd0904a9b5 264 Pfam PF08443 RimK-like ATP-grasp domain 95 241 1.1E-9 T 13-10-2018 IPR013651 ATP-grasp fold, RimK-type Reactome: R-HSA-70614 TOPB45_0516 f9685a83487fd570723a6bbd0904a9b5 264 Gene3D G3DSA:3.30.1490.20 97 156 2.9E-8 T 13-10-2018 IPR013815 ATP-grasp fold, subdomain 1 GO:0005524 TOPB45_0516 f9685a83487fd570723a6bbd0904a9b5 264 Gene3D G3DSA:3.30.470.20 158 263 5.9E-11 T 13-10-2018 TOPB45_1439 9a357b465d40ddbf1b6b4a4083d89195 255 Gene3D G3DSA:3.10.330.20 3 62 1.4E-20 T 13-10-2018 TOPB45_1439 9a357b465d40ddbf1b6b4a4083d89195 255 Gene3D G3DSA:3.40.50.150 64 255 2.2E-64 T 13-10-2018 TOPB45_1439 9a357b465d40ddbf1b6b4a4083d89195 255 Pfam PF08704 tRNA methyltransferase complex GCD14 subunit 58 233 3.4E-28 T 13-10-2018 IPR014816 tRNA (1-methyladenosine) methyltransferase catalytic subunit Gcd14 GO:0016429|GO:0030488|GO:0031515 MetaCyc: PWY-6829 TOPB45_1439 9a357b465d40ddbf1b6b4a4083d89195 255 SUPERFAMILY SSF53335 3 251 8.52E-66 T 13-10-2018 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TOPB45_1439 9a357b465d40ddbf1b6b4a4083d89195 255 PIRSF PIRSF017269 1 255 4.9E-79 T 13-10-2018 IPR014816 tRNA (1-methyladenosine) methyltransferase catalytic subunit Gcd14 GO:0016429|GO:0030488|GO:0031515 MetaCyc: PWY-6829 TOPB45_1436 680a47f2047ee029defbfb690a06a4ab 433 Pfam PF00574 Clp protease 25 189 6.2E-7 T 13-10-2018 IPR023562 Clp protease proteolytic subunit /Translocation-enhancing protein TepA TOPB45_1436 680a47f2047ee029defbfb690a06a4ab 433 SUPERFAMILY SSF141322 361 428 4.45E-15 T 13-10-2018 TOPB45_1436 680a47f2047ee029defbfb690a06a4ab 433 Gene3D G3DSA:3.90.226.10 21 241 9.1E-58 T 13-10-2018 TOPB45_1436 680a47f2047ee029defbfb690a06a4ab 433 SUPERFAMILY SSF52096 10 189 4.2E-25 T 13-10-2018 IPR029045 ClpP/crotonase-like domain superfamily TOPB45_1436 680a47f2047ee029defbfb690a06a4ab 433 Pfam PF01957 NfeD-like C-terminal, partner-binding 290 427 2.7E-30 T 13-10-2018 IPR002810 NfeD-like, C-terminal domain TOPB45_1436 680a47f2047ee029defbfb690a06a4ab 433 Gene3D G3DSA:2.40.50.140 365 432 7.3E-16 T 13-10-2018 TOPB45_0703 c31c47d69c91d9e4aa66030a00cb0fac 60 Pfam PF13597 Anaerobic ribonucleoside-triphosphate reductase 16 44 3.4E-9 T 13-10-2018 IPR012833 Ribonucleoside-triphosphate reductase, anaerobic GO:0006260|GO:0008998|GO:0016491|GO:0055114 KEGG: 00230+1.1.98.6|KEGG: 00240+1.1.98.6|MetaCyc: PWY-7187|MetaCyc: PWY-7220|MetaCyc: PWY-7222 TOPB45_0408 ef4425b5d2eae4cc79e6ada482a68119 444 Pfam PF04095 Nicotinate phosphoribosyltransferase (NAPRTase) family 153 317 1.2E-12 T 13-10-2018 IPR007229 Nicotinate phosphoribosyltransferase family KEGG: 00760+6.3.4.21|MetaCyc: PWY-5381|Reactome: R-HSA-197264 TOPB45_0408 ef4425b5d2eae4cc79e6ada482a68119 444 Gene3D G3DSA:3.20.140.10 9 417 8.4E-128 T 13-10-2018 TOPB45_0408 ef4425b5d2eae4cc79e6ada482a68119 444 SUPERFAMILY SSF51690 137 424 9.27E-87 T 13-10-2018 IPR036068 Nicotinate phosphoribosyltransferase-like, C-terminal GO:0004514|GO:0009435 KEGG: 00760+6.3.4.21|MetaCyc: PWY-5381 TOPB45_0408 ef4425b5d2eae4cc79e6ada482a68119 444 SUPERFAMILY SSF54675 7 135 2.94E-37 T 13-10-2018 TOPB45_0408 ef4425b5d2eae4cc79e6ada482a68119 444 Gene3D G3DSA:3.20.20.70 149 317 8.4E-128 T 13-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 TOPB45_0408 ef4425b5d2eae4cc79e6ada482a68119 444 PIRSF PIRSF000484 3 443 3.8E-127 T 13-10-2018 IPR007229 Nicotinate phosphoribosyltransferase family KEGG: 00760+6.3.4.21|MetaCyc: PWY-5381|Reactome: R-HSA-197264 TOPB45_0408 ef4425b5d2eae4cc79e6ada482a68119 444 TIGRFAM TIGR01513 NAPRTase_put: nicotinate phosphoribosyltransferase 8 428 6.0E-142 T 13-10-2018 IPR006405 Nicotinate phosphoribosyltransferase pncB-type GO:0004516|GO:0019358 KEGG: 00760+6.3.4.21|MetaCyc: PWY-5381|Reactome: R-HSA-197264|Reactome: R-HSA-6798695 TOPB45_0377 4b65ec1c02dd52619f29e40d6c3fa95b 566 SUPERFAMILY SSF52821 447 556 1.06E-19 T 13-10-2018 IPR036873 Rhodanese-like domain superfamily TOPB45_0377 4b65ec1c02dd52619f29e40d6c3fa95b 566 SMART SM00450 468 565 1.5E-6 T 13-10-2018 IPR001763 Rhodanese-like domain TOPB45_0377 4b65ec1c02dd52619f29e40d6c3fa95b 566 Gene3D G3DSA:3.50.50.60 2 350 5.4E-147 T 13-10-2018 IPR036188 FAD/NAD(P)-binding domain superfamily TOPB45_0377 4b65ec1c02dd52619f29e40d6c3fa95b 566 SUPERFAMILY SSF51905 1 356 1.67E-46 T 13-10-2018 IPR036188 FAD/NAD(P)-binding domain superfamily TOPB45_0377 4b65ec1c02dd52619f29e40d6c3fa95b 566 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 3 22 3.3E-22 T 13-10-2018 TOPB45_0377 4b65ec1c02dd52619f29e40d6c3fa95b 566 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 272 294 3.3E-22 T 13-10-2018 TOPB45_0377 4b65ec1c02dd52619f29e40d6c3fa95b 566 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 111 129 3.3E-22 T 13-10-2018 TOPB45_0377 4b65ec1c02dd52619f29e40d6c3fa95b 566 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 158 176 3.3E-22 T 13-10-2018 TOPB45_0377 4b65ec1c02dd52619f29e40d6c3fa95b 566 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 244 260 3.3E-22 T 13-10-2018 TOPB45_0377 4b65ec1c02dd52619f29e40d6c3fa95b 566 Pfam PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 343 444 3.7E-6 T 13-10-2018 IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GO:0045454|GO:0055114 TOPB45_0377 4b65ec1c02dd52619f29e40d6c3fa95b 566 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 2 301 6.9E-59 T 13-10-2018 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TOPB45_0377 4b65ec1c02dd52619f29e40d6c3fa95b 566 SUPERFAMILY SSF55424 333 457 4.81E-16 T 13-10-2018 IPR016156 FAD/NAD-linked reductase, dimerisation domain superfamily GO:0016491|GO:0050660|GO:0055114 TOPB45_0377 4b65ec1c02dd52619f29e40d6c3fa95b 566 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 158 183 3.1E-11 T 13-10-2018 TOPB45_0377 4b65ec1c02dd52619f29e40d6c3fa95b 566 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 2 24 3.1E-11 T 13-10-2018 TOPB45_0377 4b65ec1c02dd52619f29e40d6c3fa95b 566 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 245 259 3.1E-11 T 13-10-2018 TOPB45_0377 4b65ec1c02dd52619f29e40d6c3fa95b 566 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 287 294 3.1E-11 T 13-10-2018 TOPB45_0377 4b65ec1c02dd52619f29e40d6c3fa95b 566 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 397 412 3.1E-11 T 13-10-2018 TOPB45_0377 4b65ec1c02dd52619f29e40d6c3fa95b 566 Gene3D G3DSA:3.40.250.10 469 565 1.0E-17 T 13-10-2018 IPR036873 Rhodanese-like domain superfamily TOPB45_0377 4b65ec1c02dd52619f29e40d6c3fa95b 566 Gene3D G3DSA:3.50.50.60 120 450 5.4E-147 T 13-10-2018 IPR036188 FAD/NAD(P)-binding domain superfamily TOPB45_0164 0a34cd4359f62ecba2a70caf59a59b61 1362 Gene3D G3DSA:3.90.1100.10 342 634 2.1E-70 T 13-10-2018 TOPB45_0164 0a34cd4359f62ecba2a70caf59a59b61 1362 TIGRFAM TIGR02013 rpoB: DNA-directed RNA polymerase, beta subunit 10 1359 0.0 T 13-10-2018 IPR010243 DNA-directed RNA polymerase beta subunit, bacterial-type GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TOPB45_0164 0a34cd4359f62ecba2a70caf59a59b61 1362 Pfam PF04565 RNA polymerase Rpb2, domain 3 520 588 8.6E-29 T 13-10-2018 IPR007645 RNA polymerase Rpb2, domain 3 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TOPB45_0164 0a34cd4359f62ecba2a70caf59a59b61 1362 Pfam PF04563 RNA polymerase beta subunit 27 505 5.4E-24 T 13-10-2018 IPR007644 RNA polymerase, beta subunit, protrusion GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TOPB45_0164 0a34cd4359f62ecba2a70caf59a59b61 1362 Gene3D G3DSA:3.90.1800.10 1272 1323 1.4E-9 T 13-10-2018 TOPB45_0164 0a34cd4359f62ecba2a70caf59a59b61 1362 Pfam PF04560 RNA polymerase Rpb2, domain 7 1286 1360 2.3E-23 T 13-10-2018 IPR007641 RNA polymerase Rpb2, domain 7 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TOPB45_0164 0a34cd4359f62ecba2a70caf59a59b61 1362 Hamap MF_01321 DNA-directed RNA polymerase subunit beta [rpoB]. 13 1362 12.105 T 13-10-2018 IPR010243 DNA-directed RNA polymerase beta subunit, bacterial-type GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TOPB45_0164 0a34cd4359f62ecba2a70caf59a59b61 1362 Gene3D G3DSA:2.40.50.100 722 800 8.2E-30 T 13-10-2018 TOPB45_0164 0a34cd4359f62ecba2a70caf59a59b61 1362 Pfam PF04561 RNA polymerase Rpb2, domain 2 356 461 2.7E-13 T 13-10-2018 IPR007642 RNA polymerase Rpb2, domain 2 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TOPB45_0164 0a34cd4359f62ecba2a70caf59a59b61 1362 Pfam PF04561 RNA polymerase Rpb2, domain 2 157 263 2.0E-11 T 13-10-2018 IPR007642 RNA polymerase Rpb2, domain 2 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TOPB45_0164 0a34cd4359f62ecba2a70caf59a59b61 1362 Pfam PF00562 RNA polymerase Rpb2, domain 6 724 1284 1.9E-162 T 13-10-2018 IPR007120 DNA-directed RNA polymerase, subunit 2, hybrid-binding domain GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TOPB45_0164 0a34cd4359f62ecba2a70caf59a59b61 1362 Gene3D G3DSA:3.90.1100.10 652 720 8.8E-19 T 13-10-2018 TOPB45_0164 0a34cd4359f62ecba2a70caf59a59b61 1362 Gene3D G3DSA:3.90.1100.10 18 175 4.1E-47 T 13-10-2018 TOPB45_0164 0a34cd4359f62ecba2a70caf59a59b61 1362 Pfam PF10385 RNA polymerase beta subunit external 1 domain 598 661 2.2E-17 T 13-10-2018 IPR019462 DNA-directed RNA polymerase, beta subunit, external 1 domain GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TOPB45_0164 0a34cd4359f62ecba2a70caf59a59b61 1362 ProSitePatterns PS01166 RNA polymerases beta chain signature. 1087 1099 - T 13-10-2018 IPR007121 RNA polymerase, beta subunit, conserved site GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TOPB45_0164 0a34cd4359f62ecba2a70caf59a59b61 1362 Gene3D G3DSA:2.40.270.10 1058 1262 2.0E-80 T 13-10-2018 IPR037033 DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TOPB45_0164 0a34cd4359f62ecba2a70caf59a59b61 1362 SUPERFAMILY SSF64484 12 1360 0.0 T 13-10-2018 TOPB45_0164 0a34cd4359f62ecba2a70caf59a59b61 1362 Gene3D G3DSA:2.40.50.150 834 961 2.4E-47 T 13-10-2018 IPR014724 RNA polymerase Rpb2, OB-fold GO:0003899 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TOPB45_1145 91e3cd3622c64a50efff391050610dce 254 SMART SM00363 1 65 5.2E-13 T 13-10-2018 IPR002942 RNA-binding S4 domain GO:0003723 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_1145 91e3cd3622c64a50efff391050610dce 254 Gene3D G3DSA:3.30.70.580 62 229 3.1E-46 T 13-10-2018 TOPB45_1145 91e3cd3622c64a50efff391050610dce 254 SUPERFAMILY SSF55120 60 230 1.12E-33 T 13-10-2018 IPR020103 Pseudouridine synthase, catalytic domain superfamily GO:0001522|GO:0003723|GO:0009451|GO:0009982 TOPB45_1145 91e3cd3622c64a50efff391050610dce 254 ProSitePatterns PS01149 Rsu family of pseudouridine synthase signature. 99 113 - T 13-10-2018 IPR018496 Pseudouridine synthase, RsuA/RluB/E/F, conserved site GO:0001522|GO:0003723|GO:0009451|GO:0016866 TOPB45_1145 91e3cd3622c64a50efff391050610dce 254 Pfam PF00849 RNA pseudouridylate synthase 62 193 1.7E-16 T 13-10-2018 IPR006145 Pseudouridine synthase, RsuA/RluB/C/D/E/F GO:0001522|GO:0003723|GO:0009451|GO:0009982 TOPB45_1145 91e3cd3622c64a50efff391050610dce 254 Gene3D G3DSA:3.10.290.10 1 57 2.4E-21 T 13-10-2018 IPR036986 RNA-binding S4 domain superfamily GO:0003723 TOPB45_1145 91e3cd3622c64a50efff391050610dce 254 Pfam PF01479 S4 domain 1 43 1.5E-13 T 13-10-2018 IPR002942 RNA-binding S4 domain GO:0003723 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_1145 91e3cd3622c64a50efff391050610dce 254 TIGRFAM TIGR00093 TIGR00093: pseudouridine synthase 66 225 1.6E-40 T 13-10-2018 IPR000748 Pseudouridine synthase, RsuA/RluB/E/F GO:0001522|GO:0003723|GO:0009451|GO:0016866 TOPB45_1145 91e3cd3622c64a50efff391050610dce 254 SUPERFAMILY SSF55174 1 57 8.05E-15 T 13-10-2018 TOPB45_1145 91e3cd3622c64a50efff391050610dce 254 Gene3D G3DSA:3.30.70.1560 128 212 3.1E-46 T 13-10-2018 TOPB45_0188 505d7d6bd19b7557b5d22616a56c4f6f 148 Gene3D G3DSA:3.40.5.10 1 62 2.9E-25 T 13-10-2018 IPR036935 Ribosomal protein L9, N-terminal domain superfamily Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0188 505d7d6bd19b7557b5d22616a56c4f6f 148 SUPERFAMILY SSF55658 1 54 3.31E-19 T 13-10-2018 IPR009027 Ribosomal protein L9/RNase H1, N-terminal TOPB45_0188 505d7d6bd19b7557b5d22616a56c4f6f 148 ProSitePatterns PS00651 Ribosomal protein L9 signature. 13 40 - T 13-10-2018 IPR020070 Ribosomal protein L9, N-terminal Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0188 505d7d6bd19b7557b5d22616a56c4f6f 148 Pfam PF01281 Ribosomal protein L9, N-terminal domain 1 47 1.2E-24 T 13-10-2018 IPR020070 Ribosomal protein L9, N-terminal Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0188 505d7d6bd19b7557b5d22616a56c4f6f 148 TIGRFAM TIGR00158 L9: ribosomal protein bL9 1 147 4.5E-40 T 13-10-2018 IPR020594 Ribosomal protein L9, bacteria/chloroplast GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0188 505d7d6bd19b7557b5d22616a56c4f6f 148 Hamap MF_00503 50S ribosomal protein L9 [rplI]. 1 147 24.844 T 13-10-2018 IPR020594 Ribosomal protein L9, bacteria/chloroplast GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0188 505d7d6bd19b7557b5d22616a56c4f6f 148 Pfam PF03948 Ribosomal protein L9, C-terminal domain 65 145 1.5E-22 T 13-10-2018 IPR020069 Ribosomal protein L9, C-terminal TOPB45_0188 505d7d6bd19b7557b5d22616a56c4f6f 148 Gene3D G3DSA:3.10.430.100 63 148 8.2E-24 T 13-10-2018 IPR036791 Ribosomal protein L9, C-terminal domain superfamily TOPB45_0188 505d7d6bd19b7557b5d22616a56c4f6f 148 SUPERFAMILY SSF55653 57 147 2.49E-22 T 13-10-2018 IPR036791 Ribosomal protein L9, C-terminal domain superfamily TOPB45_0885 5079ce082196a3aa6be4e51faf09c553 566 Gene3D G3DSA:1.10.645.10 1 551 7.5E-224 T 13-10-2018 IPR029014 [NiFe]-hydrogenase, large subunit Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_0885 5079ce082196a3aa6be4e51faf09c553 566 ProSitePatterns PS00508 Nickel-dependent hydrogenases large subunit signature 2. 542 551 - T 13-10-2018 IPR018194 Nickel-dependent hydrogenase, large subunit, nickel binding site GO:0008901|GO:0016151|GO:0055114 TOPB45_0885 5079ce082196a3aa6be4e51faf09c553 566 Pfam PF00374 Nickel-dependent hydrogenase 39 551 3.5E-215 T 13-10-2018 IPR001501 Nickel-dependent hydrogenase, large subunit GO:0016151 TOPB45_0885 5079ce082196a3aa6be4e51faf09c553 566 SUPERFAMILY SSF56762 1 551 3.27E-172 T 13-10-2018 IPR029014 [NiFe]-hydrogenase, large subunit Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_0114 3f087002549a4e5e409f153a3c05134d 242 Gene3D G3DSA:3.20.20.410 1 242 1.6E-77 T 13-10-2018 IPR036520 UPF0759 superfamily TOPB45_0114 3f087002549a4e5e409f153a3c05134d 242 SUPERFAMILY SSF117396 4 241 2.88E-79 T 13-10-2018 IPR036520 UPF0759 superfamily TOPB45_0114 3f087002549a4e5e409f153a3c05134d 242 Pfam PF01904 Protein of unknown function DUF72 22 238 1.5E-62 T 13-10-2018 IPR002763 Protein of unknown function DUF72 TOPB45_0316 5ab3df6c0596a52cb63016859e31d9fe 268 SUPERFAMILY SSF103088 141 232 6.28E-6 T 13-10-2018 IPR036737 OmpA-like domain superfamily TOPB45_0705 66cf95998611f2e9b3dfd63cfb7bca9b 442 Gene3D G3DSA:1.10.260.30 326 441 1.4E-41 T 13-10-2018 IPR036891 Signal recognition particle, SRP54 subunit, M-domain superfamily GO:0006614|GO:0008312|GO:0048500 Reactome: R-HSA-1799339 TOPB45_0705 66cf95998611f2e9b3dfd63cfb7bca9b 442 SMART SM00962 100 295 2.3E-115 T 13-10-2018 IPR000897 Signal recognition particle, SRP54 subunit, GTPase domain GO:0005525|GO:0006614 Reactome: R-HSA-1799339 TOPB45_0705 66cf95998611f2e9b3dfd63cfb7bca9b 442 Pfam PF02978 Signal peptide binding domain 326 421 2.2E-32 T 13-10-2018 IPR004125 Signal recognition particle, SRP54 subunit, M-domain GO:0006614|GO:0008312|GO:0048500 Reactome: R-HSA-1799339 TOPB45_0705 66cf95998611f2e9b3dfd63cfb7bca9b 442 SMART SM00382 99 300 2.7E-11 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_0705 66cf95998611f2e9b3dfd63cfb7bca9b 442 Pfam PF02881 SRP54-type protein, helical bundle domain 5 82 4.3E-21 T 13-10-2018 IPR013822 Signal recognition particle, SRP54 subunit, helical bundle GO:0005525|GO:0006614 Reactome: R-HSA-1799339 TOPB45_0705 66cf95998611f2e9b3dfd63cfb7bca9b 442 Pfam PF00448 SRP54-type protein, GTPase domain 101 295 2.4E-76 T 13-10-2018 IPR000897 Signal recognition particle, SRP54 subunit, GTPase domain GO:0005525|GO:0006614 Reactome: R-HSA-1799339 TOPB45_0705 66cf95998611f2e9b3dfd63cfb7bca9b 442 TIGRFAM TIGR00959 ffh: signal recognition particle protein 2 424 3.9E-183 T 13-10-2018 IPR004780 Signal recognition particle protein Ffh GO:0003924|GO:0005525|GO:0006614|GO:0048500 TOPB45_0705 66cf95998611f2e9b3dfd63cfb7bca9b 442 Hamap MF_00306 Signal recognition particle 54 kDa protein [srp54]. 5 440 34.725 T 13-10-2018 IPR022941 Signal recognition particle, SRP54 subunit GO:0003924|GO:0005525|GO:0006614|GO:0048500 Reactome: R-HSA-1799339 TOPB45_0705 66cf95998611f2e9b3dfd63cfb7bca9b 442 Gene3D G3DSA:3.40.50.300 90 284 4.7E-127 T 13-10-2018 TOPB45_0705 66cf95998611f2e9b3dfd63cfb7bca9b 442 ProSitePatterns PS00300 SRP54-type proteins GTP-binding domain signature. 268 281 - T 13-10-2018 IPR000897 Signal recognition particle, SRP54 subunit, GTPase domain GO:0005525|GO:0006614 Reactome: R-HSA-1799339 TOPB45_0705 66cf95998611f2e9b3dfd63cfb7bca9b 442 Gene3D G3DSA:1.20.120.140 5 305 4.7E-127 T 13-10-2018 TOPB45_0705 66cf95998611f2e9b3dfd63cfb7bca9b 442 SUPERFAMILY SSF47446 326 426 5.56E-35 T 13-10-2018 IPR036891 Signal recognition particle, SRP54 subunit, M-domain superfamily GO:0006614|GO:0008312|GO:0048500 Reactome: R-HSA-1799339 TOPB45_0705 66cf95998611f2e9b3dfd63cfb7bca9b 442 SUPERFAMILY SSF52540 42 352 9.3E-57 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0705 66cf95998611f2e9b3dfd63cfb7bca9b 442 SMART SM00963 1 86 2.3E-31 T 13-10-2018 IPR013822 Signal recognition particle, SRP54 subunit, helical bundle GO:0005525|GO:0006614 Reactome: R-HSA-1799339 TOPB45_0762 5778ec0a15daa86cfe9ef609bbc74f31 96 ProSitePatterns PS00056 Ribosomal protein S17 signature. 55 67 - T 13-10-2018 IPR019979 Ribosomal protein S17, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0762 5778ec0a15daa86cfe9ef609bbc74f31 96 SUPERFAMILY SSF50249 4 82 4.71E-35 T 13-10-2018 IPR012340 Nucleic acid-binding, OB-fold TOPB45_0762 5778ec0a15daa86cfe9ef609bbc74f31 96 PRINTS PR00973 Ribosomal protein S17 family signature 23 46 1.3E-13 T 13-10-2018 IPR000266 Ribosomal protein S17/S11 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0762 5778ec0a15daa86cfe9ef609bbc74f31 96 PRINTS PR00973 Ribosomal protein S17 family signature 65 72 1.3E-13 T 13-10-2018 IPR000266 Ribosomal protein S17/S11 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0762 5778ec0a15daa86cfe9ef609bbc74f31 96 PRINTS PR00973 Ribosomal protein S17 family signature 55 65 1.3E-13 T 13-10-2018 IPR000266 Ribosomal protein S17/S11 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0762 5778ec0a15daa86cfe9ef609bbc74f31 96 Gene3D G3DSA:2.40.50.140 3 82 4.3E-38 T 13-10-2018 TOPB45_0762 5778ec0a15daa86cfe9ef609bbc74f31 96 TIGRFAM TIGR03635 uS17_bact: ribosomal protein uS17 4 74 2.0E-37 T 13-10-2018 IPR019984 30S ribosomal protein S17 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0762 5778ec0a15daa86cfe9ef609bbc74f31 96 Pfam PF00366 Ribosomal protein S17 9 74 2.8E-35 T 13-10-2018 IPR000266 Ribosomal protein S17/S11 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0762 5778ec0a15daa86cfe9ef609bbc74f31 96 Hamap MF_01345_B 30S ribosomal protein S17 [rpsQ]. 4 79 25.93 T 13-10-2018 IPR019984 30S ribosomal protein S17 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0762 5778ec0a15daa86cfe9ef609bbc74f31 96 ProDom PD001295 RIBOSOMAL S17 30S RIBONUCLEOPROTEIN RRNA-BINDING RNA-BINDING 40S S11 S17P S11 4 74 1.0E-24 T 13-10-2018 IPR000266 Ribosomal protein S17/S11 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0740 ce92e1f8f4e1766130c08f8b1cb0eb50 301 Pfam PF01564 Spermine/spermidine synthase domain 72 254 2.8E-30 T 13-10-2018 TOPB45_0740 ce92e1f8f4e1766130c08f8b1cb0eb50 301 Hamap MF_00198 Polyamine aminopropyltransferase [speE]. 19 301 28.468 T 13-10-2018 IPR001045 Spermidine/spermine synthases GO:0003824 KEGG: 00270+2.5.1.16|KEGG: 00330+2.5.1.16|KEGG: 00410+2.5.1.16|KEGG: 00480+2.5.1.16|Reactome: R-HSA-351202 TOPB45_0740 ce92e1f8f4e1766130c08f8b1cb0eb50 301 SUPERFAMILY SSF53335 36 300 9.45E-54 T 13-10-2018 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TOPB45_0740 ce92e1f8f4e1766130c08f8b1cb0eb50 301 Gene3D G3DSA:3.40.50.150 68 301 6.0E-50 T 13-10-2018 TOPB45_0245 0b5987c683c79c2347828e6c5214c5c6 148 Hamap MF_00984 Single-stranded DNA-binding protein. 3 109 33.975 T 13-10-2018 IPR011344 Single-stranded DNA-binding protein GO:0003697|GO:0006260 Reactome: R-HSA-2151201 TOPB45_0245 0b5987c683c79c2347828e6c5214c5c6 148 Pfam PF00436 Single-strand binding protein family 3 105 1.8E-38 T 13-10-2018 IPR000424 Primosome PriB/single-strand DNA-binding GO:0003697 Reactome: R-HSA-2151201 TOPB45_0245 0b5987c683c79c2347828e6c5214c5c6 148 TIGRFAM TIGR00621 ssb: single-stranded DNA-binding protein 2 121 5.8E-44 T 13-10-2018 IPR011344 Single-stranded DNA-binding protein GO:0003697|GO:0006260 Reactome: R-HSA-2151201 TOPB45_0245 0b5987c683c79c2347828e6c5214c5c6 148 Gene3D G3DSA:2.40.50.140 1 121 3.3E-43 T 13-10-2018 TOPB45_0245 0b5987c683c79c2347828e6c5214c5c6 148 PIRSF PIRSF002070 1 148 1.5E-41 T 13-10-2018 TOPB45_0245 0b5987c683c79c2347828e6c5214c5c6 148 SUPERFAMILY SSF50249 1 148 9.94E-47 T 13-10-2018 IPR012340 Nucleic acid-binding, OB-fold TOPB45_0956 32064c7d35a7b43604e629b751299acb 294 ProSitePatterns PS00912 Dihydroorotate dehydrogenase signature 2. 237 257 - T 13-10-2018 IPR001295 Dihydroorotate dehydrogenase, conserved site GO:0004152|GO:0006207|GO:0055114 Reactome: R-HSA-500753 TOPB45_0956 32064c7d35a7b43604e629b751299acb 294 PIRSF PIRSF000164 1 291 1.2E-60 T 13-10-2018 IPR012135 Dihydroorotate dehydrogenase, class 1/ 2 GO:0004152|GO:0006222|GO:0055114 TOPB45_0956 32064c7d35a7b43604e629b751299acb 294 Hamap MF_00224 Dihydroorotate dehydrogenase [pyrD]. 3 291 31.669 T 13-10-2018 IPR024920 Dihydroorotate dehydrogenase, class 1 GO:0004152|GO:0005737|GO:0006221 TOPB45_0956 32064c7d35a7b43604e629b751299acb 294 Gene3D G3DSA:3.20.20.70 2 291 4.1E-75 T 13-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 TOPB45_0956 32064c7d35a7b43604e629b751299acb 294 Pfam PF01180 Dihydroorotate dehydrogenase 4 282 3.9E-59 T 13-10-2018 IPR005720 Dihydroorotate dehydrogenase domain GO:0005737|GO:0016627|GO:0055114 TOPB45_0956 32064c7d35a7b43604e629b751299acb 294 TIGRFAM TIGR01037 pyrD_sub1_fam: dihydroorotate dehydrogenase family protein 4 284 3.4E-81 T 13-10-2018 IPR005720 Dihydroorotate dehydrogenase domain GO:0005737|GO:0016627|GO:0055114 TOPB45_0956 32064c7d35a7b43604e629b751299acb 294 ProSitePatterns PS00911 Dihydroorotate dehydrogenase signature 1. 43 62 - T 13-10-2018 IPR001295 Dihydroorotate dehydrogenase, conserved site GO:0004152|GO:0006207|GO:0055114 Reactome: R-HSA-500753 TOPB45_0956 32064c7d35a7b43604e629b751299acb 294 SUPERFAMILY SSF51395 2 282 4.03E-69 T 13-10-2018 TOPB45_0496 e57ba9bd6333536756758a19abf0a337 410 SUPERFAMILY SSF53218 184 332 3.14E-40 T 13-10-2018 IPR036425 MoaB/Mog-like domain superfamily TOPB45_0496 e57ba9bd6333536756758a19abf0a337 410 Gene3D G3DSA:2.170.190.11 51 148 2.2E-102 T 13-10-2018 TOPB45_0496 e57ba9bd6333536756758a19abf0a337 410 SMART SM00852 187 326 1.8E-38 T 13-10-2018 IPR001453 MoaB/Mog domain TOPB45_0496 e57ba9bd6333536756758a19abf0a337 410 TIGRFAM TIGR00177 molyb_syn: molybdenum cofactor synthesis domain 184 322 2.2E-30 T 13-10-2018 IPR001453 MoaB/Mog domain TOPB45_0496 e57ba9bd6333536756758a19abf0a337 410 SUPERFAMILY SSF63882 7 182 2.75E-50 T 13-10-2018 IPR036135 MoeA, N-terminal and linker domain superfamily GO:0032324 KEGG: 00790+2.10.1.1|MetaCyc: PWY-6823|Reactome: R-HSA-947581 TOPB45_0496 e57ba9bd6333536756758a19abf0a337 410 SUPERFAMILY SSF63867 337 410 2.35E-16 T 13-10-2018 IPR036688 MoeA, C-terminal, domain IV superfamily GO:0032324 KEGG: 00790+2.10.1.1|MetaCyc: PWY-6823|Reactome: R-HSA-947581 TOPB45_0496 e57ba9bd6333536756758a19abf0a337 410 Pfam PF03453 MoeA N-terminal region (domain I and II) 13 174 6.7E-38 T 13-10-2018 IPR005110 MoeA, N-terminal and linker domain GO:0032324 KEGG: 00790+2.10.1.1|MetaCyc: PWY-6823|Reactome: R-HSA-947581 TOPB45_0496 e57ba9bd6333536756758a19abf0a337 410 Gene3D G3DSA:3.40.980.10 182 325 2.2E-102 T 13-10-2018 IPR036425 MoaB/Mog-like domain superfamily TOPB45_0496 e57ba9bd6333536756758a19abf0a337 410 Pfam PF00994 Probable molybdopterin binding domain 187 325 2.7E-28 T 13-10-2018 IPR001453 MoaB/Mog domain TOPB45_0496 e57ba9bd6333536756758a19abf0a337 410 Gene3D G3DSA:2.40.340.10 337 410 1.2E-23 T 13-10-2018 IPR036688 MoeA, C-terminal, domain IV superfamily GO:0032324 KEGG: 00790+2.10.1.1|MetaCyc: PWY-6823|Reactome: R-HSA-947581 TOPB45_0496 e57ba9bd6333536756758a19abf0a337 410 Pfam PF03454 MoeA C-terminal region (domain IV) 340 410 8.3E-16 T 13-10-2018 IPR005111 MoeA, C-terminal, domain IV GO:0032324 KEGG: 00790+2.10.1.1|MetaCyc: PWY-6823|Reactome: R-HSA-947581 TOPB45_0496 e57ba9bd6333536756758a19abf0a337 410 Gene3D G3DSA:3.90.105.10 30 181 2.2E-102 T 13-10-2018 TOPB45_0471 9dd524645ef73e524edccfd45078bcfc 292 Gene3D G3DSA:3.10.580.10 1 128 3.7E-28 T 13-10-2018 TOPB45_0471 9dd524645ef73e524edccfd45078bcfc 292 Pfam PF00571 CBS domain 79 124 2.5E-11 T 13-10-2018 IPR000644 CBS domain TOPB45_0471 9dd524645ef73e524edccfd45078bcfc 292 Pfam PF00571 CBS domain 3 54 1.7E-8 T 13-10-2018 IPR000644 CBS domain TOPB45_0471 9dd524645ef73e524edccfd45078bcfc 292 SUPERFAMILY SSF54631 1 125 6.84E-28 T 13-10-2018 TOPB45_0471 9dd524645ef73e524edccfd45078bcfc 292 SMART SM00267 119 286 9.0E-47 T 13-10-2018 IPR000160 GGDEF domain TOPB45_0471 9dd524645ef73e524edccfd45078bcfc 292 TIGRFAM TIGR00254 GGDEF: diguanylate cyclase (GGDEF) domain 131 286 7.3E-46 T 13-10-2018 IPR000160 GGDEF domain TOPB45_0471 9dd524645ef73e524edccfd45078bcfc 292 Pfam PF00990 Diguanylate cyclase, GGDEF domain 132 282 2.0E-42 T 13-10-2018 IPR000160 GGDEF domain TOPB45_0471 9dd524645ef73e524edccfd45078bcfc 292 SMART SM00116 10 58 0.12 T 13-10-2018 IPR000644 CBS domain TOPB45_0471 9dd524645ef73e524edccfd45078bcfc 292 SMART SM00116 79 127 1.7E-12 T 13-10-2018 IPR000644 CBS domain TOPB45_0471 9dd524645ef73e524edccfd45078bcfc 292 SUPERFAMILY SSF55073 135 288 6.67E-42 T 13-10-2018 IPR029787 Nucleotide cyclase TOPB45_0471 9dd524645ef73e524edccfd45078bcfc 292 Gene3D G3DSA:3.30.70.270 131 291 1.8E-48 T 13-10-2018 TOPB45_0162 8d20fb2fabfea027633fc6186d9c12d8 89 ProSitePatterns PS00362 Ribosomal protein S15 signature. 39 69 - T 13-10-2018 IPR000589 Ribosomal protein S15 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0162 8d20fb2fabfea027633fc6186d9c12d8 89 Gene3D G3DSA:1.10.287.10 1 89 3.0E-37 T 13-10-2018 TOPB45_0162 8d20fb2fabfea027633fc6186d9c12d8 89 TIGRFAM TIGR00952 S15_bact: ribosomal protein uS15 6 89 1.4E-38 T 13-10-2018 IPR005290 Ribosomal protein S15, bacterial-type GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0162 8d20fb2fabfea027633fc6186d9c12d8 89 ProDom PD157043 RIBOSOMAL S15 RIBONUCLEOPROTEIN RRNA-BINDING RNA-BINDING 30S CHLOROPLAST S15 MITOCHONDRIAL TYPE 10 88 8.0E-28 T 13-10-2018 TOPB45_0162 8d20fb2fabfea027633fc6186d9c12d8 89 SUPERFAMILY SSF47060 3 89 1.59E-36 T 13-10-2018 IPR009068 S15/NS1, RNA-binding TOPB45_0162 8d20fb2fabfea027633fc6186d9c12d8 89 SMART SM01387 8 88 1.8E-51 T 13-10-2018 IPR000589 Ribosomal protein S15 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0162 8d20fb2fabfea027633fc6186d9c12d8 89 Hamap MF_01343_B 30S ribosomal protein S15 [rpsO]. 3 89 23.048 T 13-10-2018 IPR005290 Ribosomal protein S15, bacterial-type GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0162 8d20fb2fabfea027633fc6186d9c12d8 89 Pfam PF00312 Ribosomal protein S15 8 87 4.3E-39 T 13-10-2018 IPR000589 Ribosomal protein S15 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_1580 f9a46880667d1e10ad75aeb39822efb2 84 Gene3D G3DSA:2.40.50.140 2 67 2.2E-29 T 13-10-2018 TOPB45_1580 f9a46880667d1e10ad75aeb39822efb2 84 SUPERFAMILY SSF50249 1 66 6.86E-24 T 13-10-2018 IPR012340 Nucleic acid-binding, OB-fold TOPB45_1580 f9a46880667d1e10ad75aeb39822efb2 84 SMART SM00357 3 66 2.2E-29 T 13-10-2018 IPR011129 Cold shock domain GO:0003676 TOPB45_1580 f9a46880667d1e10ad75aeb39822efb2 84 Pfam PF00313 'Cold-shock' DNA-binding domain 3 65 6.9E-29 T 13-10-2018 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 TOPB45_1580 f9a46880667d1e10ad75aeb39822efb2 84 ProSitePatterns PS00352 'Cold-shock' domain signature. 15 33 - T 13-10-2018 IPR019844 Cold-shock conserved site TOPB45_1580 f9a46880667d1e10ad75aeb39822efb2 84 PRINTS PR00050 Cold shock protein signature 39 57 3.8E-18 T 13-10-2018 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 TOPB45_1580 f9a46880667d1e10ad75aeb39822efb2 84 PRINTS PR00050 Cold shock protein signature 4 19 3.8E-18 T 13-10-2018 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 TOPB45_1580 f9a46880667d1e10ad75aeb39822efb2 84 PRINTS PR00050 Cold shock protein signature 24 33 3.8E-18 T 13-10-2018 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 TOPB45_1580 f9a46880667d1e10ad75aeb39822efb2 84 PIRSF PIRSF002599 1 83 2.0E-24 T 13-10-2018 IPR012156 Cold shock, CspA GO:0003676 TOPB45_1348 a2e09651d9c2af5d8f47f9cb6729f0d9 327 PRINTS PR00046 Major sigma-70 factor signature 107 120 1.2E-17 T 13-10-2018 IPR000943 RNA polymerase sigma-70 GO:0003700|GO:0006352|GO:0006355 TOPB45_1348 a2e09651d9c2af5d8f47f9cb6729f0d9 327 PRINTS PR00046 Major sigma-70 factor signature 294 305 1.2E-17 T 13-10-2018 IPR000943 RNA polymerase sigma-70 GO:0003700|GO:0006352|GO:0006355 TOPB45_1348 a2e09651d9c2af5d8f47f9cb6729f0d9 327 PRINTS PR00046 Major sigma-70 factor signature 131 139 1.2E-17 T 13-10-2018 IPR000943 RNA polymerase sigma-70 GO:0003700|GO:0006352|GO:0006355 TOPB45_1348 a2e09651d9c2af5d8f47f9cb6729f0d9 327 PRINTS PR00046 Major sigma-70 factor signature 279 294 1.2E-17 T 13-10-2018 IPR000943 RNA polymerase sigma-70 GO:0003700|GO:0006352|GO:0006355 TOPB45_1348 a2e09651d9c2af5d8f47f9cb6729f0d9 327 SUPERFAMILY SSF88659 164 231 6.1E-8 T 13-10-2018 IPR013324 RNA polymerase sigma factor, region 3/4-like TOPB45_1348 a2e09651d9c2af5d8f47f9cb6729f0d9 327 SUPERFAMILY SSF88946 42 152 8.16E-36 T 13-10-2018 IPR013325 RNA polymerase sigma factor, region 2 GO:0003700|GO:0006352|GO:0006355 TOPB45_1348 a2e09651d9c2af5d8f47f9cb6729f0d9 327 Pfam PF00140 Sigma-70 factor, region 1.2 43 69 1.3E-8 T 13-10-2018 IPR009042 RNA polymerase sigma-70 region 1.2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TOPB45_1348 a2e09651d9c2af5d8f47f9cb6729f0d9 327 Pfam PF04542 Sigma-70 region 2 82 151 3.4E-13 T 13-10-2018 IPR007627 RNA polymerase sigma-70 region 2 GO:0003700|GO:0006352|GO:0006355 TOPB45_1348 a2e09651d9c2af5d8f47f9cb6729f0d9 327 Gene3D G3DSA:1.10.601.10 30 151 5.2E-30 T 13-10-2018 TOPB45_1348 a2e09651d9c2af5d8f47f9cb6729f0d9 327 SUPERFAMILY SSF88659 216 317 3.92E-15 T 13-10-2018 IPR013324 RNA polymerase sigma factor, region 3/4-like TOPB45_1348 a2e09651d9c2af5d8f47f9cb6729f0d9 327 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 81 309 9.7E-23 T 13-10-2018 IPR014284 RNA polymerase sigma-70 like domain GO:0003700|GO:0006352|GO:0006355 TOPB45_1348 a2e09651d9c2af5d8f47f9cb6729f0d9 327 ProSitePatterns PS00715 Sigma-70 factors family signature 1. 107 120 - T 13-10-2018 IPR000943 RNA polymerase sigma-70 GO:0003700|GO:0006352|GO:0006355 TOPB45_1348 a2e09651d9c2af5d8f47f9cb6729f0d9 327 ProSitePatterns PS00716 Sigma-70 factors family signature 2. 279 305 - T 13-10-2018 IPR000943 RNA polymerase sigma-70 GO:0003700|GO:0006352|GO:0006355 TOPB45_1348 a2e09651d9c2af5d8f47f9cb6729f0d9 327 Pfam PF04539 Sigma-70 region 3 168 239 6.3E-9 T 13-10-2018 IPR007624 RNA polymerase sigma-70 region 3 GO:0003700|GO:0006352|GO:0006355 TOPB45_1348 a2e09651d9c2af5d8f47f9cb6729f0d9 327 Pfam PF04545 Sigma-70, region 4 267 307 3.0E-10 T 13-10-2018 IPR007630 RNA polymerase sigma-70 region 4 GO:0003700|GO:0006352|GO:0006355 TOPB45_1348 a2e09651d9c2af5d8f47f9cb6729f0d9 327 Gene3D G3DSA:1.10.10.10 162 233 5.2E-11 T 13-10-2018 IPR036388 Winged helix-like DNA-binding domain superfamily TOPB45_1348 a2e09651d9c2af5d8f47f9cb6729f0d9 327 Gene3D G3DSA:1.10.10.10 234 313 4.3E-12 T 13-10-2018 IPR036388 Winged helix-like DNA-binding domain superfamily TOPB45_1518 9979de74842e7da6ee35589118f952f4 376 Gene3D G3DSA:3.40.50.10470 177 375 3.6E-69 T 13-10-2018 TOPB45_1518 9979de74842e7da6ee35589118f952f4 376 Pfam PF01008 Initiation factor 2 subunit family 62 364 1.3E-78 T 13-10-2018 IPR000649 Initiation factor 2B-related GO:0044237 KEGG: 00270+5.3.1.23|MetaCyc: PWY-4361|MetaCyc: PWY-7174 TOPB45_1518 9979de74842e7da6ee35589118f952f4 376 Gene3D G3DSA:1.20.120.420 16 176 1.0E-37 T 13-10-2018 IPR027363 Methylthioribose-1-phosphate isomerase, N-terminal KEGG: 00270+5.3.1.23|MetaCyc: PWY-4361|MetaCyc: PWY-7174|Reactome: R-HSA-1237112 TOPB45_1518 9979de74842e7da6ee35589118f952f4 376 TIGRFAM TIGR00512 salvage_mtnA: S-methyl-5-thioribose-1-phosphate isomerase 23 363 1.1E-125 T 13-10-2018 IPR005251 Methylthioribose-1-phosphate isomerase GO:0044249 KEGG: 00270+5.3.1.23|MetaCyc: PWY-4361|MetaCyc: PWY-7174|Reactome: R-HSA-1237112 TOPB45_1518 9979de74842e7da6ee35589118f952f4 376 SUPERFAMILY SSF100950 19 370 1.33E-110 T 13-10-2018 IPR037171 NagB/RpiA transferase-like TOPB45_1518 9979de74842e7da6ee35589118f952f4 376 TIGRFAM TIGR00524 eIF-2B_rel: eIF-2B alpha/beta/delta-related uncharacterized proteins 47 364 7.0E-108 T 13-10-2018 IPR011559 Initiation factor 2B alpha/beta/delta GO:0044249 KEGG: 00270+5.3.1.23|MetaCyc: PWY-4361|MetaCyc: PWY-7174|Reactome: R-HSA-1237112 TOPB45_1518 9979de74842e7da6ee35589118f952f4 376 Hamap MF_01678 Putative methylthioribose-1-phosphate isomerase [mtnA]. 19 374 39.721 T 13-10-2018 IPR005251 Methylthioribose-1-phosphate isomerase GO:0044249 KEGG: 00270+5.3.1.23|MetaCyc: PWY-4361|MetaCyc: PWY-7174|Reactome: R-HSA-1237112 TOPB45_0139 118e1097e3a01a1bf3e6d0b8c1e5232b 436 Gene3D G3DSA:3.80.30.20 173 400 4.3E-47 T 13-10-2018 IPR023404 Radical SAM, alpha/beta horseshoe TOPB45_0139 118e1097e3a01a1bf3e6d0b8c1e5232b 436 Pfam PF04055 Radical SAM superfamily 178 355 3.3E-26 T 13-10-2018 IPR007197 Radical SAM GO:0003824|GO:0051536 TOPB45_0139 118e1097e3a01a1bf3e6d0b8c1e5232b 436 Gene3D G3DSA:3.40.50.280 4 141 6.1E-31 T 13-10-2018 TOPB45_0139 118e1097e3a01a1bf3e6d0b8c1e5232b 436 SUPERFAMILY SSF102114 177 397 2.22E-44 T 13-10-2018 TOPB45_0139 118e1097e3a01a1bf3e6d0b8c1e5232b 436 SMART SM00729 174 402 6.2E-47 T 13-10-2018 IPR006638 Elp3/MiaB/NifB GO:0003824|GO:0051536 TOPB45_0139 118e1097e3a01a1bf3e6d0b8c1e5232b 436 Pfam PF02310 B12 binding domain 46 126 1.2E-8 T 13-10-2018 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 TOPB45_0139 118e1097e3a01a1bf3e6d0b8c1e5232b 436 TIGRFAM TIGR04013 B12_SAM_MJ_1487: B12-binding domain/radical SAM domain protein, MJ_1487 family 10 409 2.0E-143 T 13-10-2018 IPR023980 Conserved hypothetical protein CHP04013, B12-binding/radical SAM-type TOPB45_0857 0c61903b23fa8baf9d80b1228fd8b7d8 273 TIGRFAM TIGR02070 mono_pep_trsgly: monofunctional biosynthetic peptidoglycan transglycosylase 10 224 1.8E-71 T 13-10-2018 IPR011812 Biosynthetic peptidoglycan transglycosylase GO:0009252|GO:0009274|GO:0016021|GO:0016763 KEGG: 00550+2.4.1.129|MetaCyc: PWY-5265|MetaCyc: PWY-6385|MetaCyc: PWY-6470|MetaCyc: PWY-6471 TOPB45_0857 0c61903b23fa8baf9d80b1228fd8b7d8 273 SUPERFAMILY SSF53955 56 235 7.87E-63 T 13-10-2018 IPR023346 Lysozyme-like domain superfamily TOPB45_0857 0c61903b23fa8baf9d80b1228fd8b7d8 273 Pfam PF00912 Transglycosylase 58 222 3.2E-55 T 13-10-2018 IPR001264 Glycosyl transferase, family 51 KEGG: 00550+2.4.1.129|MetaCyc: PWY-5265|MetaCyc: PWY-6385|MetaCyc: PWY-6470|MetaCyc: PWY-6471 TOPB45_0857 0c61903b23fa8baf9d80b1228fd8b7d8 273 Gene3D G3DSA:1.10.3810.10 47 239 4.8E-62 T 13-10-2018 IPR036950 Penicillin binding protein transglycosylase domain KEGG: 00550+2.4.1.129|MetaCyc: PWY-5265|MetaCyc: PWY-6385|MetaCyc: PWY-6470|MetaCyc: PWY-6471 TOPB45_0857 0c61903b23fa8baf9d80b1228fd8b7d8 273 Hamap MF_00766 Biosynthetic peptidoglycan transglycosylase [mtgA]. 6 229 37.014 T 13-10-2018 IPR011812 Biosynthetic peptidoglycan transglycosylase GO:0009252|GO:0009274|GO:0016021|GO:0016763 KEGG: 00550+2.4.1.129|MetaCyc: PWY-5265|MetaCyc: PWY-6385|MetaCyc: PWY-6470|MetaCyc: PWY-6471 TOPB45_0255 a11134031d161ddb2e495f7868d9178b 298 Pfam PF13616 PPIC-type PPIASE domain 132 241 1.1E-31 T 13-10-2018 TOPB45_0255 a11134031d161ddb2e495f7868d9178b 298 SUPERFAMILY SSF54534 133 241 9.17E-34 T 13-10-2018 TOPB45_0255 a11134031d161ddb2e495f7868d9178b 298 Gene3D G3DSA:3.10.50.40 141 244 4.0E-41 T 13-10-2018 TOPB45_0255 a11134031d161ddb2e495f7868d9178b 298 Gene3D G3DSA:1.10.4030.30 36 254 4.0E-41 T 13-10-2018 TOPB45_0255 a11134031d161ddb2e495f7868d9178b 298 SUPERFAMILY SSF109998 27 171 3.26E-16 T 13-10-2018 IPR027304 Trigger factor/SurA domain superfamily TOPB45_0255 a11134031d161ddb2e495f7868d9178b 298 ProSitePatterns PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature. 181 202 - T 13-10-2018 IPR023058 Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site Reactome: R-HSA-1169408|Reactome: R-HSA-6804756|Reactome: R-HSA-6811555|Reactome: R-HSA-936440 TOPB45_1502 d2758297602a4b740597520d7724e9cf 424 SUPERFAMILY SSF55205 16 422 2.88E-108 T 13-10-2018 IPR013792 RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta GO:0003824 TOPB45_1502 d2758297602a4b740597520d7724e9cf 424 Gene3D G3DSA:3.65.10.10 22 236 2.5E-130 T 13-10-2018 IPR036968 Enolpyruvate transferase domain superfamily GO:0016765 TOPB45_1502 d2758297602a4b740597520d7724e9cf 424 Gene3D G3DSA:3.65.10.10 237 417 2.5E-130 T 13-10-2018 IPR036968 Enolpyruvate transferase domain superfamily GO:0016765 TOPB45_1502 d2758297602a4b740597520d7724e9cf 424 PIRSF PIRSF000505 2 424 1.8E-134 T 13-10-2018 IPR006264 3-phosphoshikimate 1-carboxyvinyltransferase GO:0003866|GO:0009073 KEGG: 00400+2.5.1.19|MetaCyc: PWY-6163 TOPB45_1502 d2758297602a4b740597520d7724e9cf 424 Hamap MF_00210 3-phosphoshikimate 1-carboxyvinyltransferase [aroA]. 11 424 31.325 T 13-10-2018 IPR006264 3-phosphoshikimate 1-carboxyvinyltransferase GO:0003866|GO:0009073 KEGG: 00400+2.5.1.19|MetaCyc: PWY-6163 TOPB45_1502 d2758297602a4b740597520d7724e9cf 424 Pfam PF00275 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) 16 417 2.1E-109 T 13-10-2018 IPR001986 Enolpyruvate transferase domain GO:0016765 TOPB45_1502 d2758297602a4b740597520d7724e9cf 424 ProSitePatterns PS00885 EPSP synthase signature 2. 337 355 - T 13-10-2018 IPR023193 3-phosphoshikimate 1-carboxyvinyltransferase, conserved site KEGG: 00400+2.5.1.19|MetaCyc: PWY-6163 TOPB45_1502 d2758297602a4b740597520d7724e9cf 424 TIGRFAM TIGR01356 aroA: 3-phosphoshikimate 1-carboxyvinyltransferase 17 422 1.0E-125 T 13-10-2018 IPR006264 3-phosphoshikimate 1-carboxyvinyltransferase GO:0003866|GO:0009073 KEGG: 00400+2.5.1.19|MetaCyc: PWY-6163 TOPB45_1207 58dd44744927ea238b60b9143eb667ae 164 SUPERFAMILY SSF52374 3 162 1.29E-45 T 13-10-2018 TOPB45_1207 58dd44744927ea238b60b9143eb667ae 164 Pfam PF01467 Cytidylyltransferase-like 8 139 5.3E-20 T 13-10-2018 IPR004821 Cytidyltransferase-like domain GO:0003824|GO:0009058 TOPB45_1207 58dd44744927ea238b60b9143eb667ae 164 ProDom PD016147 LIGASE LYASE CITRATE PRO-3S-LYASE SYNTHETASE TRANSFERASE CYTIDYLTRANSFERASE-RELATED:CITRATE ACETATE:SH-CITRATE CITC PLASMID 2 64 0.006 T 13-10-2018 TOPB45_1207 58dd44744927ea238b60b9143eb667ae 164 TIGRFAM TIGR01510 coaD_prev_kdtB: pantetheine-phosphate adenylyltransferase 7 163 5.6E-63 T 13-10-2018 IPR001980 Phosphopantetheine adenylyltransferase GO:0004595|GO:0015937 KEGG: 00770+2.7.7.3|MetaCyc: PWY-7851 TOPB45_1207 58dd44744927ea238b60b9143eb667ae 164 Gene3D G3DSA:3.40.50.620 2 164 4.2E-59 T 13-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TOPB45_1207 58dd44744927ea238b60b9143eb667ae 164 Hamap MF_00151 Phosphopantetheine adenylyltransferase [coaD]. 5 164 36.653 T 13-10-2018 IPR001980 Phosphopantetheine adenylyltransferase GO:0004595|GO:0015937 KEGG: 00770+2.7.7.3|MetaCyc: PWY-7851 TOPB45_1207 58dd44744927ea238b60b9143eb667ae 164 PRINTS PR01020 Lipopolysaccharide core biosynthesis protein signature 23 44 2.8E-39 T 13-10-2018 IPR001980 Phosphopantetheine adenylyltransferase GO:0004595|GO:0015937 KEGG: 00770+2.7.7.3|MetaCyc: PWY-7851 TOPB45_1207 58dd44744927ea238b60b9143eb667ae 164 PRINTS PR01020 Lipopolysaccharide core biosynthesis protein signature 118 140 2.8E-39 T 13-10-2018 IPR001980 Phosphopantetheine adenylyltransferase GO:0004595|GO:0015937 KEGG: 00770+2.7.7.3|MetaCyc: PWY-7851 TOPB45_1207 58dd44744927ea238b60b9143eb667ae 164 PRINTS PR01020 Lipopolysaccharide core biosynthesis protein signature 5 23 2.8E-39 T 13-10-2018 IPR001980 Phosphopantetheine adenylyltransferase GO:0004595|GO:0015937 KEGG: 00770+2.7.7.3|MetaCyc: PWY-7851 TOPB45_1207 58dd44744927ea238b60b9143eb667ae 164 PRINTS PR01020 Lipopolysaccharide core biosynthesis protein signature 91 107 2.8E-39 T 13-10-2018 IPR001980 Phosphopantetheine adenylyltransferase GO:0004595|GO:0015937 KEGG: 00770+2.7.7.3|MetaCyc: PWY-7851 TOPB45_1207 58dd44744927ea238b60b9143eb667ae 164 TIGRFAM TIGR00125 cyt_tran_rel: cytidyltransferase-like domain 6 65 6.4E-19 T 13-10-2018 IPR004821 Cytidyltransferase-like domain GO:0003824|GO:0009058 TOPB45_1012 e0b7b5c45ce6ce0f3dfc42b934fc4867 141 Pfam PF00892 EamA-like transporter family 5 139 2.4E-24 T 13-10-2018 IPR000620 EamA domain GO:0016020|GO:0016021 TOPB45_1012 e0b7b5c45ce6ce0f3dfc42b934fc4867 141 SUPERFAMILY SSF103481 45 139 5.36E-13 T 13-10-2018 TOPB45_0785 6b1f39da86168ccae9bca860984a4fb3 194 TIGRFAM TIGR00493 clpP: ATP-dependent Clp endopeptidase, proteolytic subunit ClpP 4 191 6.5E-99 T 13-10-2018 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 TOPB45_0785 6b1f39da86168ccae9bca860984a4fb3 194 PRINTS PR00127 Clp protease catalytic subunit P signature 20 35 1.0E-51 T 13-10-2018 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 TOPB45_0785 6b1f39da86168ccae9bca860984a4fb3 194 PRINTS PR00127 Clp protease catalytic subunit P signature 112 131 1.0E-51 T 13-10-2018 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 TOPB45_0785 6b1f39da86168ccae9bca860984a4fb3 194 PRINTS PR00127 Clp protease catalytic subunit P signature 91 108 1.0E-51 T 13-10-2018 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 TOPB45_0785 6b1f39da86168ccae9bca860984a4fb3 194 PRINTS PR00127 Clp protease catalytic subunit P signature 169 188 1.0E-51 T 13-10-2018 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 TOPB45_0785 6b1f39da86168ccae9bca860984a4fb3 194 PRINTS PR00127 Clp protease catalytic subunit P signature 60 80 1.0E-51 T 13-10-2018 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 TOPB45_0785 6b1f39da86168ccae9bca860984a4fb3 194 ProSitePatterns PS00381 Endopeptidase Clp serine active site. 91 102 - T 13-10-2018 IPR018215 ClpP, Ser active site TOPB45_0785 6b1f39da86168ccae9bca860984a4fb3 194 Gene3D G3DSA:3.90.226.10 1 194 4.9E-85 T 13-10-2018 TOPB45_0785 6b1f39da86168ccae9bca860984a4fb3 194 SUPERFAMILY SSF52096 11 191 1.63E-73 T 13-10-2018 IPR029045 ClpP/crotonase-like domain superfamily TOPB45_0785 6b1f39da86168ccae9bca860984a4fb3 194 Pfam PF00574 Clp protease 14 192 2.3E-85 T 13-10-2018 IPR023562 Clp protease proteolytic subunit /Translocation-enhancing protein TepA TOPB45_0785 6b1f39da86168ccae9bca860984a4fb3 194 Hamap MF_00444 ATP-dependent Clp protease proteolytic subunit [clpP]. 4 194 43.732 T 13-10-2018 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 TOPB45_0836 2c7d214f1ad3e0266617509e6f9cf420 288 Pfam PF01343 Peptidase family S49 98 248 2.7E-52 T 13-10-2018 IPR002142 Peptidase S49 GO:0006508|GO:0008233 TOPB45_0836 2c7d214f1ad3e0266617509e6f9cf420 288 Gene3D G3DSA:3.40.1750.20 138 204 6.7E-75 T 13-10-2018 TOPB45_0836 2c7d214f1ad3e0266617509e6f9cf420 288 PRINTS PR00127 Clp protease catalytic subunit P signature 211 230 9.7E-6 T 13-10-2018 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 TOPB45_0836 2c7d214f1ad3e0266617509e6f9cf420 288 PRINTS PR00127 Clp protease catalytic subunit P signature 105 122 9.7E-6 T 13-10-2018 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 TOPB45_0836 2c7d214f1ad3e0266617509e6f9cf420 288 PRINTS PR00127 Clp protease catalytic subunit P signature 73 93 9.7E-6 T 13-10-2018 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 TOPB45_0836 2c7d214f1ad3e0266617509e6f9cf420 288 SUPERFAMILY SSF52096 19 234 3.83E-42 T 13-10-2018 IPR029045 ClpP/crotonase-like domain superfamily TOPB45_0836 2c7d214f1ad3e0266617509e6f9cf420 288 Gene3D G3DSA:3.90.226.10 45 242 6.7E-75 T 13-10-2018 TOPB45_0836 2c7d214f1ad3e0266617509e6f9cf420 288 TIGRFAM TIGR00706 SppA_dom: signal peptide peptidase SppA, 36K type 43 247 2.8E-75 T 13-10-2018 IPR004635 Peptidase S49, SppA GO:0006508|GO:0008233 TOPB45_0734 9fd2268003752746c588ecf6b93a486e 278 SUPERFAMILY SSF52540 2 222 1.6E-67 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0734 9fd2268003752746c588ecf6b93a486e 278 SMART SM00382 26 206 3.3E-11 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_0734 9fd2268003752746c588ecf6b93a486e 278 Pfam PF00005 ABC transporter 18 158 9.1E-34 T 13-10-2018 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TOPB45_0734 9fd2268003752746c588ecf6b93a486e 278 Gene3D G3DSA:3.40.50.300 1 232 2.9E-71 T 13-10-2018 TOPB45_0734 9fd2268003752746c588ecf6b93a486e 278 ProSitePatterns PS00211 ABC transporters family signature. 131 145 - T 13-10-2018 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TOPB45_0050 973442e72a5320a3d032d3040d709a54 277 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 92 274 9.4E-31 T 13-10-2018 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0016020|GO:0055085 TOPB45_0050 973442e72a5320a3d032d3040d709a54 277 Pfam PF12911 N-terminal TM domain of oligopeptide transport permease C 2 51 1.0E-10 T 13-10-2018 IPR025966 Oligopeptide transport permease C-like, N-terminal domain TOPB45_0050 973442e72a5320a3d032d3040d709a54 277 Gene3D G3DSA:1.10.3720.10 63 276 2.5E-21 T 13-10-2018 IPR035906 MetI-like superfamily TOPB45_0050 973442e72a5320a3d032d3040d709a54 277 SUPERFAMILY SSF161098 69 257 9.29E-26 T 13-10-2018 IPR035906 MetI-like superfamily TOPB45_1355 27b0bf03ca799444a4624e8bf35c5614 701 Pfam PF00580 UvrD/REP helicase N-terminal domain 10 277 4.6E-63 T 13-10-2018 IPR034739 UvrD/AddA helicase, N-terminal GO:0005524 TOPB45_1355 27b0bf03ca799444a4624e8bf35c5614 701 Gene3D G3DSA:3.40.50.300 10 279 5.6E-83 T 13-10-2018 TOPB45_1355 27b0bf03ca799444a4624e8bf35c5614 701 SUPERFAMILY SSF52540 6 634 1.82E-136 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1355 27b0bf03ca799444a4624e8bf35c5614 701 Gene3D G3DSA:1.10.10.160 110 195 5.6E-83 T 13-10-2018 IPR013986 DExx box DNA helicase domain superfamily TOPB45_1355 27b0bf03ca799444a4624e8bf35c5614 701 Gene3D G3DSA:3.40.50.300 287 628 3.0E-81 T 13-10-2018 TOPB45_1355 27b0bf03ca799444a4624e8bf35c5614 701 Pfam PF13361 UvrD-like helicase C-terminal domain 283 605 6.5E-54 T 13-10-2018 IPR014017 UvrD-like DNA helicase, C-terminal GO:0005524|GO:0016787 TOPB45_1355 27b0bf03ca799444a4624e8bf35c5614 701 Gene3D G3DSA:1.10.486.10 388 532 3.0E-81 T 13-10-2018 TOPB45_0653 dc268e9e1ab1f30904eadc1e11e3178c 202 Pfam PF00515 Tetratricopeptide repeat 89 122 1.9E-12 T 13-10-2018 IPR001440 Tetratricopeptide repeat 1 GO:0005515 TOPB45_0653 dc268e9e1ab1f30904eadc1e11e3178c 202 SUPERFAMILY SSF48452 18 186 5.41E-41 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_0653 dc268e9e1ab1f30904eadc1e11e3178c 202 Gene3D G3DSA:1.25.40.10 86 200 6.5E-29 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_0653 dc268e9e1ab1f30904eadc1e11e3178c 202 Pfam PF13432 Tetratricopeptide repeat 26 74 2.1E-10 T 13-10-2018 TOPB45_0653 dc268e9e1ab1f30904eadc1e11e3178c 202 Gene3D G3DSA:1.25.40.10 2 48 1.2E-9 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_0653 dc268e9e1ab1f30904eadc1e11e3178c 202 SMART SM00028 157 190 14.0 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_0653 dc268e9e1ab1f30904eadc1e11e3178c 202 SMART SM00028 89 122 7.2E-10 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_0653 dc268e9e1ab1f30904eadc1e11e3178c 202 SMART SM00028 123 156 0.19 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_0653 dc268e9e1ab1f30904eadc1e11e3178c 202 SMART SM00028 21 54 7.9E-6 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_0653 dc268e9e1ab1f30904eadc1e11e3178c 202 SMART SM00028 55 88 0.19 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_0653 dc268e9e1ab1f30904eadc1e11e3178c 202 Gene3D G3DSA:1.25.40.10 49 85 5.9E-7 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_0653 dc268e9e1ab1f30904eadc1e11e3178c 202 Pfam PF13181 Tetratricopeptide repeat 123 156 4.4E-5 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_0653 dc268e9e1ab1f30904eadc1e11e3178c 202 Pfam PF13181 Tetratricopeptide repeat 159 185 0.11 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_1473 e7d348c37ebe0c54a8cf7b09f009ac2d 432 Gene3D G3DSA:3.30.2010.10 171 251 9.4E-10 T 13-10-2018 TOPB45_1473 e7d348c37ebe0c54a8cf7b09f009ac2d 432 Pfam PF01435 Peptidase family M48 177 355 3.1E-12 T 13-10-2018 IPR001915 Peptidase M48 GO:0004222|GO:0006508 TOPB45_0700 b255edb6d4dd1dc0e6345251c28a4f20 50 Gene3D G3DSA:2.20.28.10 1 37 4.3E-6 T 13-10-2018 TOPB45_0700 b255edb6d4dd1dc0e6345251c28a4f20 50 SUPERFAMILY SSF57802 1 31 2.83E-7 T 13-10-2018 TOPB45_1201 be05dcba6159adf8eab87123bae5ca3f 544 Pfam PF13183 4Fe-4S dicluster domain 91 176 5.1E-10 T 13-10-2018 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain TOPB45_1201 be05dcba6159adf8eab87123bae5ca3f 544 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 162 173 - T 13-10-2018 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site TOPB45_1201 be05dcba6159adf8eab87123bae5ca3f 544 SUPERFAMILY SSF46548 80 192 6.1E-16 T 13-10-2018 IPR009051 Alpha-helical ferredoxin GO:0051536 TOPB45_1201 be05dcba6159adf8eab87123bae5ca3f 544 Pfam PF02754 Cysteine-rich domain 398 455 1.3E-4 T 13-10-2018 IPR004017 Cysteine-rich domain TOPB45_1001 dd5329777591aeebed240a85784fc817 265 Pfam PF01075 Glycosyltransferase family 9 (heptosyltransferase) 118 247 1.1E-13 T 13-10-2018 IPR002201 Glycosyl transferase, family 9 GO:0016757 TOPB45_1001 dd5329777591aeebed240a85784fc817 265 SUPERFAMILY SSF53756 2 247 4.71E-36 T 13-10-2018 TOPB45_1001 dd5329777591aeebed240a85784fc817 265 Gene3D G3DSA:3.40.50.2000 108 251 1.3E-17 T 13-10-2018 TOPB45_1606 503ab42c870bf78d2ca4607ca3c13414 140 Gene3D G3DSA:1.10.10.10 1 82 6.9E-30 T 13-10-2018 IPR036388 Winged helix-like DNA-binding domain superfamily TOPB45_1606 503ab42c870bf78d2ca4607ca3c13414 140 Gene3D G3DSA:3.30.1490.190 84 138 2.2E-10 T 13-10-2018 TOPB45_1606 503ab42c870bf78d2ca4607ca3c13414 140 Pfam PF01475 Ferric uptake regulator family 13 105 6.4E-32 T 13-10-2018 IPR002481 Ferric-uptake regulator GO:0003700|GO:0006355 TOPB45_1606 503ab42c870bf78d2ca4607ca3c13414 140 SUPERFAMILY SSF46785 4 132 3.17E-36 T 13-10-2018 IPR036390 Winged helix DNA-binding domain superfamily TOPB45_1080 4f02a0650d40c57aca0cfa8caf931e2d 245 SUPERFAMILY SSF53448 1 240 1.73E-55 T 13-10-2018 IPR029044 Nucleotide-diphospho-sugar transferases TOPB45_1080 4f02a0650d40c57aca0cfa8caf931e2d 245 Pfam PF02348 Cytidylyltransferase 4 216 5.0E-49 T 13-10-2018 IPR003329 Acylneuraminate cytidylyltransferase KEGG: 00540+2.7.7.38|MetaCyc: PWY-1269|Reactome: R-HSA-4085001 TOPB45_1080 4f02a0650d40c57aca0cfa8caf931e2d 245 Gene3D G3DSA:3.90.550.10 1 240 8.3E-82 T 13-10-2018 IPR029044 Nucleotide-diphospho-sugar transferases TOPB45_1080 4f02a0650d40c57aca0cfa8caf931e2d 245 TIGRFAM TIGR00466 kdsB: 3-deoxy-D-manno-octulosonate cytidylyltransferase 2 235 3.7E-73 T 13-10-2018 IPR004528 3-deoxy-D-manno-octulosonate cytidylyltransferase GO:0005737|GO:0008690 KEGG: 00540+2.7.7.38|MetaCyc: PWY-1269 TOPB45_1080 4f02a0650d40c57aca0cfa8caf931e2d 245 Hamap MF_00057 8-amino-3,8-dideoxy-manno-octulosonate cytidylyltransferase [kdsB]. 1 242 38.746 T 13-10-2018 IPR004528 3-deoxy-D-manno-octulosonate cytidylyltransferase GO:0005737|GO:0008690 KEGG: 00540+2.7.7.38|MetaCyc: PWY-1269 TOPB45_1396 713c321307f60ad54bccdacc33e55a37 248 SUPERFAMILY SSF117892 49 182 3.01E-47 T 13-10-2018 IPR036013 Band 7/SPFH domain superfamily TOPB45_1396 713c321307f60ad54bccdacc33e55a37 248 PRINTS PR00721 Stomatin signature 195 218 7.8E-69 T 13-10-2018 IPR001972 Stomatin family GO:0016020 TOPB45_1396 713c321307f60ad54bccdacc33e55a37 248 PRINTS PR00721 Stomatin signature 25 47 7.8E-69 T 13-10-2018 IPR001972 Stomatin family GO:0016020 TOPB45_1396 713c321307f60ad54bccdacc33e55a37 248 PRINTS PR00721 Stomatin signature 107 124 7.8E-69 T 13-10-2018 IPR001972 Stomatin family GO:0016020 TOPB45_1396 713c321307f60ad54bccdacc33e55a37 248 PRINTS PR00721 Stomatin signature 170 191 7.8E-69 T 13-10-2018 IPR001972 Stomatin family GO:0016020 TOPB45_1396 713c321307f60ad54bccdacc33e55a37 248 PRINTS PR00721 Stomatin signature 127 150 7.8E-69 T 13-10-2018 IPR001972 Stomatin family GO:0016020 TOPB45_1396 713c321307f60ad54bccdacc33e55a37 248 PRINTS PR00721 Stomatin signature 72 93 7.8E-69 T 13-10-2018 IPR001972 Stomatin family GO:0016020 TOPB45_1396 713c321307f60ad54bccdacc33e55a37 248 PRINTS PR00721 Stomatin signature 151 169 7.8E-69 T 13-10-2018 IPR001972 Stomatin family GO:0016020 TOPB45_1396 713c321307f60ad54bccdacc33e55a37 248 Pfam PF01145 SPFH domain / Band 7 family 22 191 4.5E-38 T 13-10-2018 IPR001107 Band 7 domain TOPB45_1396 713c321307f60ad54bccdacc33e55a37 248 SMART SM00244 18 175 5.3E-70 T 13-10-2018 IPR001107 Band 7 domain TOPB45_1396 713c321307f60ad54bccdacc33e55a37 248 ProSitePatterns PS01270 Band 7 protein family signature. 131 159 - T 13-10-2018 IPR018080 Band 7/stomatin-like, conserved site TOPB45_1396 713c321307f60ad54bccdacc33e55a37 248 Gene3D G3DSA:3.30.479.30 46 177 1.9E-54 T 13-10-2018 TOPB45_0538 9ff080ea18da26515ed859cba1863781 53 ProSitePatterns PS00202 Rubredoxin signature. 33 43 - T 13-10-2018 IPR018527 Rubredoxin, iron-binding site GO:0046872 TOPB45_0538 9ff080ea18da26515ed859cba1863781 53 Pfam PF00301 Rubredoxin 3 49 6.7E-25 T 13-10-2018 IPR024935 Rubredoxin domain GO:0005506 TOPB45_0538 9ff080ea18da26515ed859cba1863781 53 SUPERFAMILY SSF57802 1 51 2.52E-23 T 13-10-2018 TOPB45_0538 9ff080ea18da26515ed859cba1863781 53 Gene3D G3DSA:2.20.28.10 1 52 8.8E-28 T 13-10-2018 TOPB45_0538 9ff080ea18da26515ed859cba1863781 53 PIRSF PIRSF000071 1 53 3.8E-29 T 13-10-2018 IPR024922 Rubredoxin GO:0005506|GO:0009055 TOPB45_0538 9ff080ea18da26515ed859cba1863781 53 PRINTS PR00163 Rubredoxin signature 3 19 2.7E-12 T 13-10-2018 IPR024935 Rubredoxin domain GO:0005506 TOPB45_0538 9ff080ea18da26515ed859cba1863781 53 PRINTS PR00163 Rubredoxin signature 33 49 2.7E-12 T 13-10-2018 IPR024935 Rubredoxin domain GO:0005506 TOPB45_0371 708c4584dda37e277c3bf900f9f5e018 368 SUPERFAMILY SSF51735 4 364 3.89E-84 T 13-10-2018 IPR036291 NAD(P)-binding domain superfamily TOPB45_0371 708c4584dda37e277c3bf900f9f5e018 368 Pfam PF01658 Myo-inositol-1-phosphate synthase 200 308 1.4E-31 T 13-10-2018 IPR013021 Myo-inositol-1-phosphate synthase, GAPDH-like KEGG: 00521+5.5.1.4|KEGG: 00562+5.5.1.4|MetaCyc: PWY-2301|MetaCyc: PWY-4661|MetaCyc: PWY-6372|MetaCyc: PWY-6580|MetaCyc: PWY-6664|Reactome: R-HSA-1855183 TOPB45_0371 708c4584dda37e277c3bf900f9f5e018 368 SUPERFAMILY SSF55347 198 308 5.36E-36 T 13-10-2018 TOPB45_0371 708c4584dda37e277c3bf900f9f5e018 368 Gene3D G3DSA:3.30.360.10 199 308 6.0E-118 T 13-10-2018 TOPB45_0371 708c4584dda37e277c3bf900f9f5e018 368 PIRSF PIRSF015578 1 365 3.5E-93 T 13-10-2018 IPR002587 Myo-inositol-1-phosphate synthase GO:0004512|GO:0006021|GO:0008654 KEGG: 00521+5.5.1.4|KEGG: 00562+5.5.1.4|MetaCyc: PWY-2301|MetaCyc: PWY-4661|MetaCyc: PWY-6372|MetaCyc: PWY-6580|MetaCyc: PWY-6664|Reactome: R-HSA-1855183 TOPB45_0371 708c4584dda37e277c3bf900f9f5e018 368 Gene3D G3DSA:3.40.50.720 5 361 6.0E-118 T 13-10-2018 TOPB45_0261 83f29b74a8767619cf72327663fcbfc5 320 PRINTS PR00100 Aspartate/ornithine carbamoyltransferase superfamily signature 52 71 1.9E-16 T 13-10-2018 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 TOPB45_0261 83f29b74a8767619cf72327663fcbfc5 320 PRINTS PR00100 Aspartate/ornithine carbamoyltransferase superfamily signature 263 272 1.9E-16 T 13-10-2018 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 TOPB45_0261 83f29b74a8767619cf72327663fcbfc5 320 PRINTS PR00100 Aspartate/ornithine carbamoyltransferase superfamily signature 275 298 1.9E-16 T 13-10-2018 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 TOPB45_0261 83f29b74a8767619cf72327663fcbfc5 320 PRINTS PR00100 Aspartate/ornithine carbamoyltransferase superfamily signature 136 147 1.9E-16 T 13-10-2018 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 TOPB45_0261 83f29b74a8767619cf72327663fcbfc5 320 Pfam PF02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain 6 149 8.0E-44 T 13-10-2018 IPR006132 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding GO:0006520|GO:0016743 TOPB45_0261 83f29b74a8767619cf72327663fcbfc5 320 Hamap MF_00001 Aspartate carbamoyltransferase [pyrB]. 5 312 39.133 T 13-10-2018 IPR002082 Aspartate carbamoyltransferase GO:0004070|GO:0006207 KEGG: 00240+2.1.3.2|KEGG: 00250+2.1.3.2|MetaCyc: PWY-5686|MetaCyc: PWY-7790|MetaCyc: PWY-7791|Reactome: R-HSA-500753 TOPB45_0261 83f29b74a8767619cf72327663fcbfc5 320 Gene3D G3DSA:3.40.50.1370 7 307 3.6E-91 T 13-10-2018 IPR036901 Aspartate/ornithine carbamoyltransferase superfamily GO:0006520|GO:0016597|GO:0016743 TOPB45_0261 83f29b74a8767619cf72327663fcbfc5 320 ProSitePatterns PS00097 Aspartate and ornithine carbamoyltransferases signature. 52 59 - T 13-10-2018 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 TOPB45_0261 83f29b74a8767619cf72327663fcbfc5 320 SUPERFAMILY SSF53671 2 311 9.43E-92 T 13-10-2018 IPR036901 Aspartate/ornithine carbamoyltransferase superfamily GO:0006520|GO:0016597|GO:0016743 TOPB45_0261 83f29b74a8767619cf72327663fcbfc5 320 TIGRFAM TIGR00670 asp_carb_tr: aspartate carbamoyltransferase 6 309 5.9E-95 T 13-10-2018 IPR002082 Aspartate carbamoyltransferase GO:0004070|GO:0006207 KEGG: 00240+2.1.3.2|KEGG: 00250+2.1.3.2|MetaCyc: PWY-5686|MetaCyc: PWY-7790|MetaCyc: PWY-7791|Reactome: R-HSA-500753 TOPB45_0261 83f29b74a8767619cf72327663fcbfc5 320 Gene3D G3DSA:3.40.50.1370 136 297 3.6E-91 T 13-10-2018 IPR036901 Aspartate/ornithine carbamoyltransferase superfamily GO:0006520|GO:0016597|GO:0016743 TOPB45_0261 83f29b74a8767619cf72327663fcbfc5 320 Pfam PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain 156 307 7.8E-24 T 13-10-2018 IPR006131 Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain GO:0006520|GO:0016597|GO:0016743 TOPB45_0261 83f29b74a8767619cf72327663fcbfc5 320 PRINTS PR00101 Aspartate carbamoyltransferase signature 291 305 6.3E-33 T 13-10-2018 IPR002082 Aspartate carbamoyltransferase GO:0004070|GO:0006207 KEGG: 00240+2.1.3.2|KEGG: 00250+2.1.3.2|MetaCyc: PWY-5686|MetaCyc: PWY-7790|MetaCyc: PWY-7791|Reactome: R-HSA-500753 TOPB45_0261 83f29b74a8767619cf72327663fcbfc5 320 PRINTS PR00101 Aspartate carbamoyltransferase signature 135 152 6.3E-33 T 13-10-2018 IPR002082 Aspartate carbamoyltransferase GO:0004070|GO:0006207 KEGG: 00240+2.1.3.2|KEGG: 00250+2.1.3.2|MetaCyc: PWY-5686|MetaCyc: PWY-7790|MetaCyc: PWY-7791|Reactome: R-HSA-500753 TOPB45_0261 83f29b74a8767619cf72327663fcbfc5 320 PRINTS PR00101 Aspartate carbamoyltransferase signature 226 235 6.3E-33 T 13-10-2018 IPR002082 Aspartate carbamoyltransferase GO:0004070|GO:0006207 KEGG: 00240+2.1.3.2|KEGG: 00250+2.1.3.2|MetaCyc: PWY-5686|MetaCyc: PWY-7790|MetaCyc: PWY-7791|Reactome: R-HSA-500753 TOPB45_0261 83f29b74a8767619cf72327663fcbfc5 320 PRINTS PR00101 Aspartate carbamoyltransferase signature 42 64 6.3E-33 T 13-10-2018 IPR002082 Aspartate carbamoyltransferase GO:0004070|GO:0006207 KEGG: 00240+2.1.3.2|KEGG: 00250+2.1.3.2|MetaCyc: PWY-5686|MetaCyc: PWY-7790|MetaCyc: PWY-7791|Reactome: R-HSA-500753 TOPB45_0261 83f29b74a8767619cf72327663fcbfc5 320 PRINTS PR00101 Aspartate carbamoyltransferase signature 267 272 6.3E-33 T 13-10-2018 IPR002082 Aspartate carbamoyltransferase GO:0004070|GO:0006207 KEGG: 00240+2.1.3.2|KEGG: 00250+2.1.3.2|MetaCyc: PWY-5686|MetaCyc: PWY-7790|MetaCyc: PWY-7791|Reactome: R-HSA-500753 TOPB45_0261 83f29b74a8767619cf72327663fcbfc5 320 PRINTS PR00101 Aspartate carbamoyltransferase signature 80 89 6.3E-33 T 13-10-2018 IPR002082 Aspartate carbamoyltransferase GO:0004070|GO:0006207 KEGG: 00240+2.1.3.2|KEGG: 00250+2.1.3.2|MetaCyc: PWY-5686|MetaCyc: PWY-7790|MetaCyc: PWY-7791|Reactome: R-HSA-500753 TOPB45_1325 23ad1df736ff63ad86092d8a275ebd4f 127 Gene3D G3DSA:3.40.50.2300 2 126 2.9E-40 T 13-10-2018 TOPB45_1325 23ad1df736ff63ad86092d8a275ebd4f 127 SMART SM00448 7 121 2.0E-36 T 13-10-2018 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TOPB45_1325 23ad1df736ff63ad86092d8a275ebd4f 127 Pfam PF00072 Response regulator receiver domain 9 121 7.3E-32 T 13-10-2018 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TOPB45_1325 23ad1df736ff63ad86092d8a275ebd4f 127 SUPERFAMILY SSF52172 6 126 1.99E-38 T 13-10-2018 IPR011006 CheY-like superfamily TOPB45_0527 cad4260ac88934a32a85ebaa647ae322 289 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 86 274 8.5E-24 T 13-10-2018 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0016020|GO:0055085 TOPB45_0527 cad4260ac88934a32a85ebaa647ae322 289 Gene3D G3DSA:1.10.3720.10 62 276 1.4E-30 T 13-10-2018 IPR035906 MetI-like superfamily TOPB45_0527 cad4260ac88934a32a85ebaa647ae322 289 TIGRFAM TIGR00974 3a0107s02c: phosphate ABC transporter, permease protein PstA 13 275 1.5E-83 T 13-10-2018 IPR005672 Phosphate transport system permease protein PstA GO:0005315|GO:0005887|GO:0035435 TOPB45_0527 cad4260ac88934a32a85ebaa647ae322 289 SUPERFAMILY SSF161098 22 271 2.06E-32 T 13-10-2018 IPR035906 MetI-like superfamily TOPB45_0635 b5aaaad92c0dcf5577a983e5fc5924cc 440 Pfam PF01979 Amidohydrolase family 56 403 6.6E-74 T 13-10-2018 IPR006680 Amidohydrolase-related GO:0016787 TOPB45_0635 b5aaaad92c0dcf5577a983e5fc5924cc 440 Gene3D G3DSA:3.20.20.140 60 349 3.3E-152 T 13-10-2018 TOPB45_0635 b5aaaad92c0dcf5577a983e5fc5924cc 440 SUPERFAMILY SSF51338 4 428 3.4E-26 T 13-10-2018 IPR011059 Metal-dependent hydrolase, composite domain superfamily GO:0016810 TOPB45_0635 b5aaaad92c0dcf5577a983e5fc5924cc 440 Hamap MF_01281 5'-deoxyadenosine deaminase [dadD]. 2 430 43.109 T 13-10-2018 IPR023512 Deaminase MtaD/DadD GO:0019239 TOPB45_0635 b5aaaad92c0dcf5577a983e5fc5924cc 440 SUPERFAMILY SSF51556 59 353 9.83E-99 T 13-10-2018 IPR032466 Metal-dependent hydrolase TOPB45_0635 b5aaaad92c0dcf5577a983e5fc5924cc 440 Gene3D G3DSA:2.30.40.10 14 422 3.3E-152 T 13-10-2018 IPR011059 Metal-dependent hydrolase, composite domain superfamily GO:0016810 TOPB45_0970 f6406d5df56190d8001264eede2e7f2d 441 ProSitePatterns PS00688 Sigma-54 interaction domain C-terminal part signature. 351 360 - T 13-10-2018 IPR025944 Sigma-54 interaction domain, conserved site TOPB45_0970 f6406d5df56190d8001264eede2e7f2d 441 Gene3D G3DSA:1.10.8.60 309 375 2.1E-21 T 13-10-2018 TOPB45_0970 f6406d5df56190d8001264eede2e7f2d 441 SMART SM00448 5 117 2.2E-28 T 13-10-2018 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TOPB45_0970 f6406d5df56190d8001264eede2e7f2d 441 Pfam PF00158 Sigma-54 interaction domain 146 304 3.3E-63 T 13-10-2018 IPR002078 RNA polymerase sigma factor 54 interaction domain GO:0005524|GO:0006355|GO:0008134 TOPB45_0970 f6406d5df56190d8001264eede2e7f2d 441 SUPERFAMILY SSF52540 146 376 2.19E-65 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0970 f6406d5df56190d8001264eede2e7f2d 441 SMART SM00382 159 301 2.5E-9 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_0970 f6406d5df56190d8001264eede2e7f2d 441 ProSitePatterns PS00675 Sigma-54 interaction domain ATP-binding region A signature. 163 176 - T 13-10-2018 IPR025662 Sigma-54 interaction domain, ATP-binding site 1 TOPB45_0970 f6406d5df56190d8001264eede2e7f2d 441 Gene3D G3DSA:3.40.50.300 144 308 1.3E-60 T 13-10-2018 TOPB45_0970 f6406d5df56190d8001264eede2e7f2d 441 PRINTS PR01590 FIS bacterial regulatory protein HTH signature 419 439 3.6E-14 T 13-10-2018 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 TOPB45_0970 f6406d5df56190d8001264eede2e7f2d 441 PRINTS PR01590 FIS bacterial regulatory protein HTH signature 402 419 3.6E-14 T 13-10-2018 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 TOPB45_0970 f6406d5df56190d8001264eede2e7f2d 441 SUPERFAMILY SSF46689 350 439 3.84E-17 T 13-10-2018 IPR009057 Homeobox-like domain superfamily GO:0003677 TOPB45_0970 f6406d5df56190d8001264eede2e7f2d 441 Gene3D G3DSA:1.10.10.60 381 440 6.8E-20 T 13-10-2018 TOPB45_0970 f6406d5df56190d8001264eede2e7f2d 441 SUPERFAMILY SSF52172 6 182 2.85E-35 T 13-10-2018 IPR011006 CheY-like superfamily TOPB45_0970 f6406d5df56190d8001264eede2e7f2d 441 Pfam PF00072 Response regulator receiver domain 7 109 8.0E-25 T 13-10-2018 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TOPB45_0970 f6406d5df56190d8001264eede2e7f2d 441 Pfam PF02954 Bacterial regulatory protein, Fis family 395 436 4.0E-18 T 13-10-2018 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 TOPB45_0970 f6406d5df56190d8001264eede2e7f2d 441 Gene3D G3DSA:3.40.50.2300 1 135 1.9E-33 T 13-10-2018 TOPB45_1614 f9689a9f6121defaf7b2fe038ce50046 237 Pfam PF00902 Sec-independent protein translocase protein (TatC) 13 219 2.4E-34 T 13-10-2018 IPR002033 Sec-independent periplasmic protein translocase TatC GO:0016021 TOPB45_1614 f9689a9f6121defaf7b2fe038ce50046 237 PRINTS PR01840 Bacterial Sec-independent translocation TatC protein family signature 154 182 5.7E-9 T 13-10-2018 IPR002033 Sec-independent periplasmic protein translocase TatC GO:0016021 TOPB45_1614 f9689a9f6121defaf7b2fe038ce50046 237 PRINTS PR01840 Bacterial Sec-independent translocation TatC protein family signature 104 130 5.7E-9 T 13-10-2018 IPR002033 Sec-independent periplasmic protein translocase TatC GO:0016021 TOPB45_1614 f9689a9f6121defaf7b2fe038ce50046 237 PRINTS PR01840 Bacterial Sec-independent translocation TatC protein family signature 10 37 5.7E-9 T 13-10-2018 IPR002033 Sec-independent periplasmic protein translocase TatC GO:0016021 TOPB45_1614 f9689a9f6121defaf7b2fe038ce50046 237 PRINTS PR01840 Bacterial Sec-independent translocation TatC protein family signature 86 104 5.7E-9 T 13-10-2018 IPR002033 Sec-independent periplasmic protein translocase TatC GO:0016021 TOPB45_0955 ca39f3ea4ccc7e77395784c35e0858c5 288 Gene3D G3DSA:3.90.1280.10 230 286 7.2E-18 T 13-10-2018 IPR016154 Heat shock protein Hsp33, C-terminal GO:0005737|GO:0006457|GO:0051082 TOPB45_0955 ca39f3ea4ccc7e77395784c35e0858c5 288 SUPERFAMILY SSF64397 3 236 5.1E-64 T 13-10-2018 IPR016153 Heat shock protein Hsp33, N-terminal GO:0005737|GO:0006457|GO:0051082 TOPB45_0955 ca39f3ea4ccc7e77395784c35e0858c5 288 PIRSF PIRSF005261 1 287 6.6E-73 T 13-10-2018 IPR000397 Heat shock protein Hsp33 GO:0005737|GO:0006457|GO:0051082 TOPB45_0955 ca39f3ea4ccc7e77395784c35e0858c5 288 Gene3D G3DSA:3.55.30.10 1 229 2.0E-79 T 13-10-2018 IPR016153 Heat shock protein Hsp33, N-terminal GO:0005737|GO:0006457|GO:0051082 TOPB45_0955 ca39f3ea4ccc7e77395784c35e0858c5 288 Pfam PF01430 Hsp33 protein 3 273 3.6E-80 T 13-10-2018 IPR000397 Heat shock protein Hsp33 GO:0005737|GO:0006457|GO:0051082 TOPB45_0955 ca39f3ea4ccc7e77395784c35e0858c5 288 Hamap MF_00117 33 kDa chaperonin [hslO]. 1 286 34.005 T 13-10-2018 IPR000397 Heat shock protein Hsp33 GO:0005737|GO:0006457|GO:0051082 TOPB45_0955 ca39f3ea4ccc7e77395784c35e0858c5 288 SUPERFAMILY SSF118352 228 285 3.66E-17 T 13-10-2018 IPR016154 Heat shock protein Hsp33, C-terminal GO:0005737|GO:0006457|GO:0051082 TOPB45_1251 82fa68a6e57aa8980cfbad0c1668a4ad 455 SUPERFAMILY SSF53686 29 426 4.71E-112 T 13-10-2018 IPR036052 Tryptophan synthase beta subunit-like PLP-dependent enzyme TOPB45_1251 82fa68a6e57aa8980cfbad0c1668a4ad 455 Hamap MF_00133 Tryptophan synthase beta chain [trpB]. 21 427 42.278 T 13-10-2018 IPR023026 Tryptophan synthase beta chain/beta chain-like GO:0000162|GO:0004834 KEGG: 00260+4.2.1.20|KEGG: 00400+4.2.1.20 TOPB45_1251 82fa68a6e57aa8980cfbad0c1668a4ad 455 TIGRFAM TIGR01415 trpB_rel: pyridoxal-phosphate dependent TrpB-like enzyme 13 429 5.0E-214 T 13-10-2018 IPR006316 Tryptophan synthase, beta chain-like GO:0000162|GO:0004834|GO:0030170 KEGG: 00260+4.2.1.20|KEGG: 00400+4.2.1.20 TOPB45_1251 82fa68a6e57aa8980cfbad0c1668a4ad 455 PIRSF PIRSF500824 1 436 1.0E-214 T 13-10-2018 IPR006316 Tryptophan synthase, beta chain-like GO:0000162|GO:0004834|GO:0030170 KEGG: 00260+4.2.1.20|KEGG: 00400+4.2.1.20 TOPB45_1251 82fa68a6e57aa8980cfbad0c1668a4ad 455 PIRSF PIRSF001413 9 433 1.8E-131 T 13-10-2018 IPR023026 Tryptophan synthase beta chain/beta chain-like GO:0000162|GO:0004834 KEGG: 00260+4.2.1.20|KEGG: 00400+4.2.1.20 TOPB45_1251 82fa68a6e57aa8980cfbad0c1668a4ad 455 Gene3D G3DSA:3.40.50.1100 13 420 1.7E-178 T 13-10-2018 TOPB45_1251 82fa68a6e57aa8980cfbad0c1668a4ad 455 Gene3D G3DSA:3.40.50.1100 14 238 1.7E-178 T 13-10-2018 TOPB45_1251 82fa68a6e57aa8980cfbad0c1668a4ad 455 ProSitePatterns PS00168 Tryptophan synthase beta chain pyridoxal-phosphate attachment site. 105 119 - T 13-10-2018 IPR006653 Tryptophan synthase, beta chain, conserved site GO:0004834|GO:0006568 KEGG: 00260+4.2.1.20|KEGG: 00400+4.2.1.20 TOPB45_1251 82fa68a6e57aa8980cfbad0c1668a4ad 455 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 77 414 4.5E-44 T 13-10-2018 IPR001926 Pyridoxal-phosphate dependent enzyme TOPB45_0580 0883a7105ed498eaa5c96525fb08adec 283 Pfam PF03446 NAD binding domain of 6-phosphogluconate dehydrogenase 2 151 7.1E-31 T 13-10-2018 IPR006115 6-phosphogluconate dehydrogenase, NADP-binding GO:0050661 TOPB45_0580 0883a7105ed498eaa5c96525fb08adec 283 SUPERFAMILY SSF51735 1 154 8.78E-36 T 13-10-2018 IPR036291 NAD(P)-binding domain superfamily TOPB45_0580 0883a7105ed498eaa5c96525fb08adec 283 PIRSF PIRSF000103 1 281 2.1E-67 T 13-10-2018 IPR015815 3-hydroxyisobutyrate dehydrogenase-related GO:0016491|GO:0055114 Reactome: R-HSA-70895 TOPB45_0580 0883a7105ed498eaa5c96525fb08adec 283 Pfam PF14833 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase 157 277 1.6E-23 T 13-10-2018 IPR029154 3-hydroxyisobutyrate dehydrogenase, NAD-binding domain GO:0051287 TOPB45_0580 0883a7105ed498eaa5c96525fb08adec 283 Gene3D G3DSA:3.40.50.720 1 153 2.8E-37 T 13-10-2018 TOPB45_0580 0883a7105ed498eaa5c96525fb08adec 283 SUPERFAMILY SSF48179 156 279 4.08E-27 T 13-10-2018 IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily GO:0055114 TOPB45_0580 0883a7105ed498eaa5c96525fb08adec 283 Gene3D G3DSA:1.10.1040.10 155 281 4.6E-28 T 13-10-2018 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 TOPB45_1569 23f5ee4dcfa11f6e50962c3d94969100 235 PRINTS PR01008 Flagellar L-ring protein signature 148 163 1.8E-17 T 13-10-2018 IPR000527 Flagellar L-ring protein GO:0003774|GO:0009427|GO:0071973 TOPB45_1569 23f5ee4dcfa11f6e50962c3d94969100 235 PRINTS PR01008 Flagellar L-ring protein signature 174 190 1.8E-17 T 13-10-2018 IPR000527 Flagellar L-ring protein GO:0003774|GO:0009427|GO:0071973 TOPB45_1569 23f5ee4dcfa11f6e50962c3d94969100 235 PRINTS PR01008 Flagellar L-ring protein signature 195 209 1.8E-17 T 13-10-2018 IPR000527 Flagellar L-ring protein GO:0003774|GO:0009427|GO:0071973 TOPB45_1569 23f5ee4dcfa11f6e50962c3d94969100 235 PRINTS PR01008 Flagellar L-ring protein signature 70 82 1.8E-17 T 13-10-2018 IPR000527 Flagellar L-ring protein GO:0003774|GO:0009427|GO:0071973 TOPB45_1569 23f5ee4dcfa11f6e50962c3d94969100 235 Pfam PF02107 Flagellar L-ring protein 49 234 6.0E-50 T 13-10-2018 IPR000527 Flagellar L-ring protein GO:0003774|GO:0009427|GO:0071973 TOPB45_1569 23f5ee4dcfa11f6e50962c3d94969100 235 Hamap MF_00415 Flagellar L-ring protein [flgH]. 6 233 23.021 T 13-10-2018 IPR000527 Flagellar L-ring protein GO:0003774|GO:0009427|GO:0071973 TOPB45_0152 7a0bb19551ef3b41517d8358805cd04b 123 PRINTS PR01264 Bacterial mechano-sensitive ion channel signature 71 79 5.6E-8 T 13-10-2018 IPR001185 Large-conductance mechanosensitive channel GO:0008381|GO:0016021|GO:0034220 TOPB45_0152 7a0bb19551ef3b41517d8358805cd04b 123 PRINTS PR01264 Bacterial mechano-sensitive ion channel signature 4 18 5.6E-8 T 13-10-2018 IPR001185 Large-conductance mechanosensitive channel GO:0008381|GO:0016021|GO:0034220 TOPB45_0152 7a0bb19551ef3b41517d8358805cd04b 123 PRINTS PR01264 Bacterial mechano-sensitive ion channel signature 81 90 5.6E-8 T 13-10-2018 IPR001185 Large-conductance mechanosensitive channel GO:0008381|GO:0016021|GO:0034220 TOPB45_0152 7a0bb19551ef3b41517d8358805cd04b 123 SUPERFAMILY SSF81330 10 114 3.66E-28 T 13-10-2018 IPR036019 Gated mechanosensitive channel TOPB45_0152 7a0bb19551ef3b41517d8358805cd04b 123 ProSitePatterns PS01327 Large-conductance mechanosensitive channels mscL family signature. 11 24 - T 13-10-2018 IPR019823 Large-conductance mechanosensitive channel, conserved site TOPB45_0152 7a0bb19551ef3b41517d8358805cd04b 123 TIGRFAM TIGR00220 mscL: large conductance mechanosensitive channel protein 1 121 2.0E-32 T 13-10-2018 IPR001185 Large-conductance mechanosensitive channel GO:0008381|GO:0016021|GO:0034220 TOPB45_0152 7a0bb19551ef3b41517d8358805cd04b 123 Hamap MF_00115 Large-conductance mechanosensitive channel [mscL]. 1 121 21.325 T 13-10-2018 IPR001185 Large-conductance mechanosensitive channel GO:0008381|GO:0016021|GO:0034220 TOPB45_0152 7a0bb19551ef3b41517d8358805cd04b 123 Gene3D G3DSA:1.10.1200.120 1 123 2.4E-34 T 13-10-2018 IPR036019 Gated mechanosensitive channel TOPB45_0152 7a0bb19551ef3b41517d8358805cd04b 123 Pfam PF01741 Large-conductance mechanosensitive channel, MscL 1 119 8.3E-36 T 13-10-2018 IPR037673 Large-conductance mechanosensitive channel/anditomin synthesis protein L TOPB45_1157 cd63ca7852a198bf189f5264a2b89b1d 385 SUPERFAMILY SSF101960 50 379 6.67E-76 T 13-10-2018 IPR037284 SUF system FeS cluster assembly, SufBD superfamily TOPB45_1157 cd63ca7852a198bf189f5264a2b89b1d 385 Pfam PF01458 Uncharacterized protein family (UPF0051) 135 358 5.6E-52 T 13-10-2018 IPR000825 SUF system FeS cluster assembly, SufBD GO:0016226 TOPB45_0301 0cb7ccdb940ea5b21576a455bca9861e 237 SUPERFAMILY SSF53271 81 234 3.15E-26 T 13-10-2018 IPR029057 Phosphoribosyltransferase-like TOPB45_0301 0cb7ccdb940ea5b21576a455bca9861e 237 Gene3D G3DSA:3.40.50.2020 145 236 2.2E-17 T 13-10-2018 TOPB45_0301 0cb7ccdb940ea5b21576a455bca9861e 237 Pfam PF00156 Phosphoribosyl transferase domain 180 233 1.1E-10 T 13-10-2018 IPR000836 Phosphoribosyltransferase domain GO:0009116 TOPB45_0550 5ab3681bd49a4beeee26ff1823357779 657 SMART SM00283 270 531 7.5E-75 T 13-10-2018 IPR004089 Methyl-accepting chemotaxis protein (MCP) signalling domain GO:0007165|GO:0016020 TOPB45_0550 5ab3681bd49a4beeee26ff1823357779 657 PRINTS PR00260 Bacterial chemotaxis sensory transducer signature 11 36 5.2E-27 T 13-10-2018 IPR004090 Chemotaxis methyl-accepting receptor GO:0004888|GO:0006935|GO:0007165|GO:0016020 TOPB45_0550 5ab3681bd49a4beeee26ff1823357779 657 PRINTS PR00260 Bacterial chemotaxis sensory transducer signature 368 395 5.2E-27 T 13-10-2018 IPR004090 Chemotaxis methyl-accepting receptor GO:0004888|GO:0006935|GO:0007165|GO:0016020 TOPB45_0550 5ab3681bd49a4beeee26ff1823357779 657 PRINTS PR00260 Bacterial chemotaxis sensory transducer signature 445 474 5.2E-27 T 13-10-2018 IPR004090 Chemotaxis methyl-accepting receptor GO:0004888|GO:0006935|GO:0007165|GO:0016020 TOPB45_0550 5ab3681bd49a4beeee26ff1823357779 657 PRINTS PR00260 Bacterial chemotaxis sensory transducer signature 291 320 5.2E-27 T 13-10-2018 IPR004090 Chemotaxis methyl-accepting receptor GO:0004888|GO:0006935|GO:0007165|GO:0016020 TOPB45_0550 5ab3681bd49a4beeee26ff1823357779 657 PRINTS PR00260 Bacterial chemotaxis sensory transducer signature 397 426 5.2E-27 T 13-10-2018 IPR004090 Chemotaxis methyl-accepting receptor GO:0004888|GO:0006935|GO:0007165|GO:0016020 TOPB45_0550 5ab3681bd49a4beeee26ff1823357779 657 Pfam PF13682 Chemoreceptor zinc-binding domain 547 613 1.3E-8 T 13-10-2018 IPR025991 Chemoreceptor zinc-binding domain TOPB45_0550 5ab3681bd49a4beeee26ff1823357779 657 Pfam PF00015 Methyl-accepting chemotaxis protein (MCP) signalling domain 335 499 3.3E-45 T 13-10-2018 IPR004089 Methyl-accepting chemotaxis protein (MCP) signalling domain GO:0007165|GO:0016020 TOPB45_0550 5ab3681bd49a4beeee26ff1823357779 657 Gene3D G3DSA:1.10.287.950 203 528 2.4E-69 T 13-10-2018 TOPB45_0550 5ab3681bd49a4beeee26ff1823357779 657 SUPERFAMILY SSF58104 222 532 3.66E-70 T 13-10-2018 TOPB45_0945 2d9353e5a51c4ee2a4b245bbc86252fe 310 Gene3D G3DSA:3.30.43.10 1 93 9.0E-25 T 13-10-2018 IPR016167 FAD-binding, type PCMH, subdomain 1 TOPB45_0945 2d9353e5a51c4ee2a4b245bbc86252fe 310 Gene3D G3DSA:3.90.78.10 223 308 1.2E-34 T 13-10-2018 IPR036635 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain superfamily GO:0008762|GO:0055114 KEGG: 00520+1.3.1.98|KEGG: 00550+1.3.1.98|MetaCyc: PWY-6386|MetaCyc: PWY-6387|MetaCyc: PWY-7953 TOPB45_0945 2d9353e5a51c4ee2a4b245bbc86252fe 310 Pfam PF02873 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain 211 304 2.2E-29 T 13-10-2018 IPR011601 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal GO:0008762|GO:0055114 KEGG: 00520+1.3.1.98|KEGG: 00550+1.3.1.98|MetaCyc: PWY-6386|MetaCyc: PWY-6387|MetaCyc: PWY-7953 TOPB45_0945 2d9353e5a51c4ee2a4b245bbc86252fe 310 SUPERFAMILY SSF56176 28 216 4.02E-35 T 13-10-2018 IPR036318 FAD-binding, type PCMH-like superfamily GO:0050660 TOPB45_0945 2d9353e5a51c4ee2a4b245bbc86252fe 310 Hamap MF_00037 UDP-N-acetylenolpyruvoylglucosamine reductase [murB]. 1 310 76.94 T 13-10-2018 IPR003170 UDP-N-acetylenolpyruvoylglucosamine reductase GO:0008762|GO:0055114 KEGG: 00520+1.3.1.98|KEGG: 00550+1.3.1.98|MetaCyc: PWY-6386|MetaCyc: PWY-6387|MetaCyc: PWY-7953 TOPB45_0945 2d9353e5a51c4ee2a4b245bbc86252fe 310 Pfam PF01565 FAD binding domain 44 162 2.4E-18 T 13-10-2018 IPR006094 FAD linked oxidase, N-terminal GO:0016491|GO:0050660|GO:0055114 TOPB45_0945 2d9353e5a51c4ee2a4b245bbc86252fe 310 Gene3D G3DSA:3.30.465.10 105 221 2.0E-27 T 13-10-2018 IPR016169 FAD-binding, type PCMH, subdomain 2 TOPB45_0945 2d9353e5a51c4ee2a4b245bbc86252fe 310 SUPERFAMILY SSF56194 207 307 3.14E-35 T 13-10-2018 IPR036635 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain superfamily GO:0008762|GO:0055114 KEGG: 00520+1.3.1.98|KEGG: 00550+1.3.1.98|MetaCyc: PWY-6386|MetaCyc: PWY-6387|MetaCyc: PWY-7953 TOPB45_0945 2d9353e5a51c4ee2a4b245bbc86252fe 310 TIGRFAM TIGR00179 murB: UDP-N-acetylenolpyruvoylglucosamine reductase 29 306 5.1E-69 T 13-10-2018 IPR003170 UDP-N-acetylenolpyruvoylglucosamine reductase GO:0008762|GO:0055114 KEGG: 00520+1.3.1.98|KEGG: 00550+1.3.1.98|MetaCyc: PWY-6386|MetaCyc: PWY-6387|MetaCyc: PWY-7953 TOPB45_0263 8457d67f8c10fa8f570a9635696e8bda 301 Hamap MF_00388 UDP-3-O-acyl-N-acetylglucosamine deacetylase [lpxC]. 2 277 35.097 T 13-10-2018 IPR004463 UDP-3-O-acyl N-acetylglucosamine deacetylase GO:0008759|GO:0009245 KEGG: 00540+3.5.1.108 TOPB45_0263 8457d67f8c10fa8f570a9635696e8bda 301 Gene3D G3DSA:3.30.230.20 1 125 9.2E-36 T 13-10-2018 IPR015870 UDP-3-O-acyl N-acetylglucosamine deacetylase, N-terminal GO:0008759|GO:0009245 KEGG: 00540+3.5.1.108 TOPB45_0263 8457d67f8c10fa8f570a9635696e8bda 301 Pfam PF03331 UDP-3-O-acyl N-acetylglycosamine deacetylase 4 273 7.5E-84 T 13-10-2018 IPR004463 UDP-3-O-acyl N-acetylglucosamine deacetylase GO:0008759|GO:0009245 KEGG: 00540+3.5.1.108 TOPB45_0263 8457d67f8c10fa8f570a9635696e8bda 301 TIGRFAM TIGR00325 lpxC: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 4 271 3.0E-71 T 13-10-2018 IPR004463 UDP-3-O-acyl N-acetylglucosamine deacetylase GO:0008759|GO:0009245 KEGG: 00540+3.5.1.108 TOPB45_0263 8457d67f8c10fa8f570a9635696e8bda 301 Gene3D G3DSA:3.30.1700.10 129 290 1.7E-46 T 13-10-2018 IPR011334 UDP-3-O-acyl N-acetylglucosamine deacetylase, C-terminal GO:0008759|GO:0009245 KEGG: 00540+3.5.1.108 TOPB45_0263 8457d67f8c10fa8f570a9635696e8bda 301 SUPERFAMILY SSF54211 136 274 1.44E-35 T 13-10-2018 IPR020568 Ribosomal protein S5 domain 2-type fold TOPB45_0263 8457d67f8c10fa8f570a9635696e8bda 301 SUPERFAMILY SSF54211 3 120 4.17E-30 T 13-10-2018 IPR020568 Ribosomal protein S5 domain 2-type fold TOPB45_0249 a1484035c8f5da1197cc58defae884c5 455 Pfam PF02310 B12 binding domain 20 121 2.5E-13 T 13-10-2018 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 TOPB45_0249 a1484035c8f5da1197cc58defae884c5 455 Gene3D G3DSA:3.80.30.20 177 372 1.1E-27 T 13-10-2018 IPR023404 Radical SAM, alpha/beta horseshoe TOPB45_0249 a1484035c8f5da1197cc58defae884c5 455 Pfam PF04055 Radical SAM superfamily 182 342 7.8E-22 T 13-10-2018 IPR007197 Radical SAM GO:0003824|GO:0051536 TOPB45_0249 a1484035c8f5da1197cc58defae884c5 455 ProSitePatterns PS01278 Methylthiotransferase radical SAM domain signature. 182 202 - T 13-10-2018 IPR020612 Methylthiotransferase, conserved site GO:0051539 TOPB45_0249 a1484035c8f5da1197cc58defae884c5 455 SUPERFAMILY SSF102114 148 374 1.57E-39 T 13-10-2018 TOPB45_0249 a1484035c8f5da1197cc58defae884c5 455 Gene3D G3DSA:3.40.50.280 14 134 1.4E-12 T 13-10-2018 TOPB45_0249 a1484035c8f5da1197cc58defae884c5 455 SMART SM00729 178 383 6.1E-36 T 13-10-2018 IPR006638 Elp3/MiaB/NifB GO:0003824|GO:0051536 TOPB45_0420 87bf46140e62a9c9c31ac5bc9e77563a 254 SUPERFAMILY SSF56529 47 250 7.2E-76 T 13-10-2018 IPR036663 Fumarylacetoacetase-like, C-terminal domain superfamily GO:0003824 TOPB45_0420 87bf46140e62a9c9c31ac5bc9e77563a 254 Pfam PF10370 Domain of unknown function (DUF2437) 1 49 4.7E-8 T 13-10-2018 IPR018833 Domain of unknown function DUF2437 TOPB45_0420 87bf46140e62a9c9c31ac5bc9e77563a 254 Gene3D G3DSA:3.90.850.10 25 253 6.8E-81 T 13-10-2018 IPR036663 Fumarylacetoacetase-like, C-terminal domain superfamily GO:0003824 TOPB45_0420 87bf46140e62a9c9c31ac5bc9e77563a 254 Pfam PF01557 Fumarylacetoacetate (FAA) hydrolase family 54 249 1.8E-62 T 13-10-2018 IPR011234 Fumarylacetoacetase-like, C-terminal GO:0003824 TOPB45_0948 7ce4015b0c96668f765de39aec55a5dc 372 SMART SM00864 17 209 2.2E-108 T 13-10-2018 IPR003008 Tubulin/FtsZ, GTPase domain GO:0003924 Reactome: R-HSA-380320 TOPB45_0948 7ce4015b0c96668f765de39aec55a5dc 372 Pfam PF00091 Tubulin/FtsZ family, GTPase domain 17 175 2.3E-43 T 13-10-2018 IPR003008 Tubulin/FtsZ, GTPase domain GO:0003924 Reactome: R-HSA-380320 TOPB45_0948 7ce4015b0c96668f765de39aec55a5dc 372 SUPERFAMILY SSF52490 17 209 4.71E-68 T 13-10-2018 IPR036525 Tubulin/FtsZ, GTPase domain superfamily Reactome: R-HSA-380320 TOPB45_0948 7ce4015b0c96668f765de39aec55a5dc 372 SUPERFAMILY SSF55307 208 325 7.33E-35 T 13-10-2018 IPR008280 Tubulin/FtsZ, C-terminal Reactome: R-HSA-380320 TOPB45_0948 7ce4015b0c96668f765de39aec55a5dc 372 PRINTS PR00423 Cell division protein FtsZ signature 130 151 1.6E-40 T 13-10-2018 IPR003008 Tubulin/FtsZ, GTPase domain GO:0003924 Reactome: R-HSA-380320 TOPB45_0948 7ce4015b0c96668f765de39aec55a5dc 372 PRINTS PR00423 Cell division protein FtsZ signature 193 215 1.6E-40 T 13-10-2018 IPR003008 Tubulin/FtsZ, GTPase domain GO:0003924 Reactome: R-HSA-380320 TOPB45_0948 7ce4015b0c96668f765de39aec55a5dc 372 PRINTS PR00423 Cell division protein FtsZ signature 102 122 1.6E-40 T 13-10-2018 IPR003008 Tubulin/FtsZ, GTPase domain GO:0003924 Reactome: R-HSA-380320 TOPB45_0948 7ce4015b0c96668f765de39aec55a5dc 372 PRINTS PR00423 Cell division protein FtsZ signature 217 238 1.6E-40 T 13-10-2018 IPR003008 Tubulin/FtsZ, GTPase domain GO:0003924 Reactome: R-HSA-380320 TOPB45_0948 7ce4015b0c96668f765de39aec55a5dc 372 Gene3D G3DSA:3.40.50.1440 7 223 4.5E-79 T 13-10-2018 IPR036525 Tubulin/FtsZ, GTPase domain superfamily Reactome: R-HSA-380320 TOPB45_0948 7ce4015b0c96668f765de39aec55a5dc 372 Gene3D G3DSA:3.30.1330.20 230 350 1.2E-34 T 13-10-2018 IPR037103 Tubulin/FtsZ, C-terminal domain superfamily Reactome: R-HSA-380320 TOPB45_0948 7ce4015b0c96668f765de39aec55a5dc 372 TIGRFAM TIGR00065 ftsZ: cell division protein FtsZ 13 346 2.0E-126 T 13-10-2018 IPR000158 Cell division protein FtsZ GO:0005525 TOPB45_0948 7ce4015b0c96668f765de39aec55a5dc 372 ProSitePatterns PS01135 FtsZ protein signature 2. 101 122 - T 13-10-2018 IPR020805 Cell division protein FtsZ, conserved site GO:0005525|GO:0005737 TOPB45_0948 7ce4015b0c96668f765de39aec55a5dc 372 Hamap MF_00909 Cell division protein FtsZ [ftsZ]. 13 362 36.944 T 13-10-2018 IPR000158 Cell division protein FtsZ GO:0005525 TOPB45_0948 7ce4015b0c96668f765de39aec55a5dc 372 Pfam PF12327 FtsZ family, C-terminal domain 227 323 1.4E-28 T 13-10-2018 IPR024757 Cell division protein FtsZ, C-terminal TOPB45_0948 7ce4015b0c96668f765de39aec55a5dc 372 SMART SM00865 211 331 7.9E-46 T 13-10-2018 IPR018316 Tubulin/FtsZ, 2-layer sandwich domain Reactome: R-HSA-380320 TOPB45_0086 9ef551903e4fafc3e06b99d6ed350f3e 536 Pfam PF07559 Flagellar basal body protein FlaE 212 416 4.4E-17 T 13-10-2018 IPR011491 Flagellar hook protein FlgE TOPB45_0086 9ef551903e4fafc3e06b99d6ed350f3e 536 TIGRFAM TIGR03506 FlgEFG_subfam: flagellar hook-basal body protein 6 516 4.5E-92 T 13-10-2018 IPR020013 Flagellar hook-basal body protein, FlgE/F/G TOPB45_0086 9ef551903e4fafc3e06b99d6ed350f3e 536 Gene3D G3DSA:2.60.98.20 159 324 4.8E-5 T 13-10-2018 IPR037058 Flagellar hook protein FlgE superfamily TOPB45_0086 9ef551903e4fafc3e06b99d6ed350f3e 536 Pfam PF06429 Flagellar basal body rod FlgEFG protein C-terminal 457 534 9.6E-20 T 13-10-2018 IPR010930 Flagellar basal-body/hook protein, C-terminal domain TOPB45_0086 9ef551903e4fafc3e06b99d6ed350f3e 536 SUPERFAMILY SSF117143 84 496 2.35E-59 T 13-10-2018 IPR037925 Flagellar hook-basal body protein, FlgE/F/G-like TOPB45_0517 b92faea58ce6da27fde19f0655aa292d 454 Pfam PF00919 Uncharacterized protein family UPF0004 3 88 8.1E-19 T 13-10-2018 IPR013848 Methylthiotransferase, N-terminal GO:0051539 TOPB45_0517 b92faea58ce6da27fde19f0655aa292d 454 TIGRFAM TIGR01579 MiaB-like-C: MiaB-like tRNA modifying enzyme 6 421 1.0E-116 T 13-10-2018 IPR006467 MiaB-like tRNA modifying enzyme GO:0016740 TOPB45_0517 b92faea58ce6da27fde19f0655aa292d 454 Gene3D G3DSA:3.80.30.20 149 385 7.6E-75 T 13-10-2018 IPR023404 Radical SAM, alpha/beta horseshoe TOPB45_0517 b92faea58ce6da27fde19f0655aa292d 454 SUPERFAMILY SSF102114 142 377 1.44E-50 T 13-10-2018 TOPB45_0517 b92faea58ce6da27fde19f0655aa292d 454 TIGRFAM TIGR00089 TIGR00089: radical SAM methylthiotransferase, MiaB/RimO family 3 448 5.3E-112 T 13-10-2018 IPR005839 Methylthiotransferase GO:0006400|GO:0016740|GO:0051539 TOPB45_0517 b92faea58ce6da27fde19f0655aa292d 454 SMART SM00729 151 373 5.4E-46 T 13-10-2018 IPR006638 Elp3/MiaB/NifB GO:0003824|GO:0051536 TOPB45_0517 b92faea58ce6da27fde19f0655aa292d 454 Pfam PF04055 Radical SAM superfamily 156 331 2.2E-23 T 13-10-2018 IPR007197 Radical SAM GO:0003824|GO:0051536 TOPB45_0517 b92faea58ce6da27fde19f0655aa292d 454 ProSitePatterns PS01278 Methylthiotransferase radical SAM domain signature. 155 175 - T 13-10-2018 IPR020612 Methylthiotransferase, conserved site GO:0051539 TOPB45_0517 b92faea58ce6da27fde19f0655aa292d 454 Gene3D G3DSA:3.40.50.12160 2 131 4.3E-16 T 13-10-2018 IPR038135 Methylthiotransferase, N-terminal domain superfamily TOPB45_0718 2b7f0575d3d2a0f973134a5da525f66f 268 Gene3D G3DSA:3.30.70.660 111 251 1.2E-45 T 13-10-2018 IPR020095 Pseudouridine synthase I, TruA, C-terminal GO:0003723|GO:0009982 TOPB45_0718 2b7f0575d3d2a0f973134a5da525f66f 268 Gene3D G3DSA:3.30.70.580 4 110 2.7E-34 T 13-10-2018 TOPB45_0718 2b7f0575d3d2a0f973134a5da525f66f 268 TIGRFAM TIGR00071 hisT_truA: tRNA pseudouridine(38-40) synthase 8 247 2.0E-63 T 13-10-2018 IPR001406 Pseudouridine synthase I, TruA GO:0001522|GO:0003723|GO:0009451|GO:0009982 TOPB45_0718 2b7f0575d3d2a0f973134a5da525f66f 268 SUPERFAMILY SSF55120 5 257 9.93E-85 T 13-10-2018 IPR020103 Pseudouridine synthase, catalytic domain superfamily GO:0001522|GO:0003723|GO:0009451|GO:0009982 TOPB45_0718 2b7f0575d3d2a0f973134a5da525f66f 268 Hamap MF_00171 tRNA pseudouridine synthase A [truA]. 7 252 34.835 T 13-10-2018 IPR001406 Pseudouridine synthase I, TruA GO:0001522|GO:0003723|GO:0009451|GO:0009982 TOPB45_0718 2b7f0575d3d2a0f973134a5da525f66f 268 PIRSF PIRSF001430 6 266 1.3E-84 T 13-10-2018 IPR001406 Pseudouridine synthase I, TruA GO:0001522|GO:0003723|GO:0009451|GO:0009982 TOPB45_0718 2b7f0575d3d2a0f973134a5da525f66f 268 Pfam PF01416 tRNA pseudouridine synthase 13 105 1.2E-9 T 13-10-2018 IPR020097 Pseudouridine synthase I, TruA, alpha/beta domain GO:0001522|GO:0003723|GO:0009451|GO:0009982 TOPB45_0718 2b7f0575d3d2a0f973134a5da525f66f 268 Pfam PF01416 tRNA pseudouridine synthase 153 253 1.8E-26 T 13-10-2018 IPR020097 Pseudouridine synthase I, TruA, alpha/beta domain GO:0001522|GO:0003723|GO:0009451|GO:0009982 TOPB45_0957 5eb4889fa96deac53614d0825c40111f 257 Gene3D G3DSA:2.10.240.10 214 253 1.0E-10 T 13-10-2018 IPR037117 Dihydroorotate dehydrogenase, electron transfer subunit, Fe-S binding domain superfamily TOPB45_0957 5eb4889fa96deac53614d0825c40111f 257 Pfam PF00175 Oxidoreductase NAD-binding domain 106 199 3.1E-4 T 13-10-2018 IPR001433 Oxidoreductase FAD/NAD(P)-binding GO:0016491|GO:0055114 TOPB45_0957 5eb4889fa96deac53614d0825c40111f 257 Gene3D G3DSA:3.40.50.80 96 213 1.4E-20 T 13-10-2018 IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domain TOPB45_0957 5eb4889fa96deac53614d0825c40111f 257 Pfam PF10418 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B 214 252 6.0E-13 T 13-10-2018 IPR019480 Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain TOPB45_0957 5eb4889fa96deac53614d0825c40111f 257 SUPERFAMILY SSF52343 91 251 9.95E-27 T 13-10-2018 IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domain TOPB45_0957 5eb4889fa96deac53614d0825c40111f 257 SUPERFAMILY SSF63380 3 96 2.15E-17 T 13-10-2018 IPR017938 Riboflavin synthase-like beta-barrel TOPB45_0957 5eb4889fa96deac53614d0825c40111f 257 PIRSF PIRSF006816 1 255 1.7E-57 T 13-10-2018 IPR012165 Cytochrome-c3 hydrogenase, gamma subunit GO:0006221|GO:0050660|GO:0051537 TOPB45_0957 5eb4889fa96deac53614d0825c40111f 257 Gene3D G3DSA:2.40.30.10 2 94 3.2E-25 T 13-10-2018 TOPB45_0711 dd72deb40afa01f211f06596c72d3261 717 Gene3D G3DSA:3.40.1110.10 444 544 6.9E-76 T 13-10-2018 IPR023299 P-type ATPase, cytoplasmic domain N GO:0000166 Reactome: R-HSA-936837 TOPB45_0711 dd72deb40afa01f211f06596c72d3261 717 SUPERFAMILY SSF55008 3 72 1.96E-15 T 13-10-2018 IPR036163 Heavy metal-associated domain superfamily GO:0030001|GO:0046872 TOPB45_0711 dd72deb40afa01f211f06596c72d3261 717 PRINTS PR00120 H+-transporting ATPase (proton pump) signature 612 628 8.4E-13 T 13-10-2018 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 TOPB45_0711 dd72deb40afa01f211f06596c72d3261 717 PRINTS PR00120 H+-transporting ATPase (proton pump) signature 643 668 8.4E-13 T 13-10-2018 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 TOPB45_0711 dd72deb40afa01f211f06596c72d3261 717 PRINTS PR00120 H+-transporting ATPase (proton pump) signature 584 600 8.4E-13 T 13-10-2018 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 TOPB45_0711 dd72deb40afa01f211f06596c72d3261 717 SUPERFAMILY SSF81665 158 426 2.22E-9 T 13-10-2018 IPR023298 P-type ATPase, transmembrane domain superfamily Reactome: R-HSA-936837 TOPB45_0711 dd72deb40afa01f211f06596c72d3261 717 TIGRFAM TIGR01525 ATPase-IB_hvy: heavy metal translocating P-type ATPase 151 713 1.1E-174 T 13-10-2018 IPR027256 P-type ATPase, subfamily IB GO:0006812|GO:0016021|GO:0019829 Reactome: R-HSA-936837 TOPB45_0711 dd72deb40afa01f211f06596c72d3261 717 Gene3D G3DSA:3.40.50.1000 414 664 6.9E-76 T 13-10-2018 IPR023214 HAD superfamily TOPB45_0711 dd72deb40afa01f211f06596c72d3261 717 Pfam PF00403 Heavy-metal-associated domain 10 68 5.0E-12 T 13-10-2018 IPR006121 Heavy metal-associated domain, HMA GO:0030001|GO:0046872 TOPB45_0711 dd72deb40afa01f211f06596c72d3261 717 ProSitePatterns PS01047 Heavy-metal-associated domain. 12 41 - T 13-10-2018 IPR017969 Heavy-metal-associated, conserved site GO:0030001|GO:0046872 TOPB45_0711 dd72deb40afa01f211f06596c72d3261 717 Gene3D G3DSA:2.70.150.20 201 316 1.2E-34 T 13-10-2018 TOPB45_0711 dd72deb40afa01f211f06596c72d3261 717 SUPERFAMILY SSF81653 216 312 1.2E-22 T 13-10-2018 IPR008250 P-type ATPase, A domain superfamily Reactome: R-HSA-936837 TOPB45_0711 dd72deb40afa01f211f06596c72d3261 717 ProSitePatterns PS00154 E1-E2 ATPases phosphorylation site. 435 441 - T 13-10-2018 IPR018303 P-type ATPase, phosphorylation site Reactome: R-HSA-936837 TOPB45_0711 dd72deb40afa01f211f06596c72d3261 717 Gene3D G3DSA:3.30.70.100 7 89 2.6E-16 T 13-10-2018 TOPB45_0711 dd72deb40afa01f211f06596c72d3261 717 Pfam PF00122 E1-E2 ATPase 212 412 4.0E-48 T 13-10-2018 TOPB45_0711 dd72deb40afa01f211f06596c72d3261 717 TIGRFAM TIGR01494 ATPase_P-type: HAD ATPase, P-type, family IC 184 700 3.6E-89 T 13-10-2018 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 TOPB45_0711 dd72deb40afa01f211f06596c72d3261 717 Pfam PF00702 haloacid dehalogenase-like hydrolase 430 626 8.9E-37 T 13-10-2018 TOPB45_0711 dd72deb40afa01f211f06596c72d3261 717 SUPERFAMILY SSF56784 431 712 6.0E-59 T 13-10-2018 IPR036412 HAD-like superfamily TOPB45_0711 dd72deb40afa01f211f06596c72d3261 717 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 262 276 1.1E-30 T 13-10-2018 TOPB45_0711 dd72deb40afa01f211f06596c72d3261 717 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 612 631 1.1E-30 T 13-10-2018 TOPB45_0711 dd72deb40afa01f211f06596c72d3261 717 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 635 647 1.1E-30 T 13-10-2018 TOPB45_0711 dd72deb40afa01f211f06596c72d3261 717 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 537 548 1.1E-30 T 13-10-2018 TOPB45_0711 dd72deb40afa01f211f06596c72d3261 717 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 433 447 1.1E-30 T 13-10-2018 TOPB45_0711 dd72deb40afa01f211f06596c72d3261 717 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 559 569 1.1E-30 T 13-10-2018 TOPB45_1039 8d4581fd6168e3061bbd385e6427a439 1138 Gene3D G3DSA:3.40.50.300 870 1133 9.6E-42 T 13-10-2018 TOPB45_1039 8d4581fd6168e3061bbd385e6427a439 1138 Gene3D G3DSA:3.40.50.300 1 246 5.9E-52 T 13-10-2018 TOPB45_1039 8d4581fd6168e3061bbd385e6427a439 1138 Hamap MF_01894 Chromosome partition protein Smc [smc]. 1 1130 17.125 T 13-10-2018 IPR011890 Structural maintenance of chromosomes protein, prokaryotic GO:0007062|GO:0030261 TOPB45_1039 8d4581fd6168e3061bbd385e6427a439 1138 PIRSF PIRSF005719 608 1131 3.0E-86 T 13-10-2018 IPR024704 Structural maintenance of chromosomes protein TOPB45_1039 8d4581fd6168e3061bbd385e6427a439 1138 PIRSF PIRSF005719 1 514 3.7E-102 T 13-10-2018 IPR024704 Structural maintenance of chromosomes protein TOPB45_1039 8d4581fd6168e3061bbd385e6427a439 1138 Pfam PF02463 RecF/RecN/SMC N terminal domain 2 1121 6.9E-44 T 13-10-2018 IPR003395 RecF/RecN/SMC, N-terminal TOPB45_1039 8d4581fd6168e3061bbd385e6427a439 1138 SUPERFAMILY SSF52540 1 1133 1.33E-44 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1039 8d4581fd6168e3061bbd385e6427a439 1138 SUPERFAMILY SSF57997 633 843 4.32E-7 T 13-10-2018 TOPB45_1553 a40ab4f436f0bbf7939395051638f8e1 628 Pfam PF03717 Penicillin-binding Protein dimerisation domain 74 242 5.6E-43 T 13-10-2018 IPR005311 Penicillin-binding protein, dimerisation domain GO:0008658 TOPB45_1553 a40ab4f436f0bbf7939395051638f8e1 628 SUPERFAMILY SSF56601 261 612 6.8E-102 T 13-10-2018 IPR012338 Beta-lactamase/transpeptidase-like TOPB45_1553 a40ab4f436f0bbf7939395051638f8e1 628 TIGRFAM TIGR03423 pbp2_mrdA: penicillin-binding protein 2 29 607 4.9E-194 T 13-10-2018 IPR017790 Penicillin-binding protein 2 GO:0008658|GO:0009002|GO:0009252|GO:0016020 KEGG: 00550+3.4.16.4|MetaCyc: PWY-5265|MetaCyc: PWY-6471 TOPB45_1553 a40ab4f436f0bbf7939395051638f8e1 628 Pfam PF00905 Penicillin binding protein transpeptidase domain 277 604 1.5E-77 T 13-10-2018 IPR001460 Penicillin-binding protein, transpeptidase GO:0008658 TOPB45_1553 a40ab4f436f0bbf7939395051638f8e1 628 SUPERFAMILY SSF56519 68 259 1.96E-45 T 13-10-2018 IPR036138 Penicillin-binding protein, dimerisation domain superfamily GO:0008658 TOPB45_1553 a40ab4f436f0bbf7939395051638f8e1 628 Gene3D G3DSA:3.90.1310.30 67 258 6.6E-39 T 13-10-2018 TOPB45_1553 a40ab4f436f0bbf7939395051638f8e1 628 Gene3D G3DSA:3.40.710.10 259 612 1.3E-102 T 13-10-2018 TOPB45_1607 395e398aae1db5a31f11257aea60a92a 270 SUPERFAMILY SSF102705 5 261 2.88E-67 T 13-10-2018 IPR036069 GTP cyclohydrolase 1 type 2/Nif3 superfamily TOPB45_1607 395e398aae1db5a31f11257aea60a92a 270 Pfam PF01784 NIF3 (NGG1p interacting factor 3) 7 244 5.0E-63 T 13-10-2018 IPR002678 GTP cyclohydrolase 1 type 2/Nif3 TOPB45_1607 395e398aae1db5a31f11257aea60a92a 270 Gene3D G3DSA:3.40.1390.30 102 223 1.7E-58 T 13-10-2018 TOPB45_1607 395e398aae1db5a31f11257aea60a92a 270 TIGRFAM TIGR00486 YbgI_SA1388: dinuclear metal center protein, YbgI/SA1388 family 5 258 9.7E-55 T 13-10-2018 IPR002678 GTP cyclohydrolase 1 type 2/Nif3 TOPB45_1607 395e398aae1db5a31f11257aea60a92a 270 Gene3D G3DSA:3.40.1390.30 6 233 1.7E-58 T 13-10-2018 TOPB45_0362 fb84818777dec9356dbc9c5ce07d9f84 389 TIGRFAM TIGR02032 GG-red-SF: geranylgeranyl reductase family 8 293 2.6E-57 T 13-10-2018 IPR011777 Geranylgeranyl reductase family GO:0016628|GO:0055114 TOPB45_0362 fb84818777dec9356dbc9c5ce07d9f84 389 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 9 31 4.7E-6 T 13-10-2018 TOPB45_0362 fb84818777dec9356dbc9c5ce07d9f84 389 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 152 161 4.7E-6 T 13-10-2018 TOPB45_0362 fb84818777dec9356dbc9c5ce07d9f84 389 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 8 168 3.9E-11 T 13-10-2018 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TOPB45_0362 fb84818777dec9356dbc9c5ce07d9f84 389 Gene3D G3DSA:3.50.50.60 5 388 5.0E-78 T 13-10-2018 IPR036188 FAD/NAD(P)-binding domain superfamily TOPB45_0362 fb84818777dec9356dbc9c5ce07d9f84 389 SUPERFAMILY SSF51905 5 356 1.24E-36 T 13-10-2018 IPR036188 FAD/NAD(P)-binding domain superfamily TOPB45_0512 7ec405f21f07f97beadde3ab8d6f7aed 352 Pfam PF00534 Glycosyl transferases group 1 188 319 9.5E-23 T 13-10-2018 IPR001296 Glycosyl transferase, family 1 TOPB45_0512 7ec405f21f07f97beadde3ab8d6f7aed 352 Gene3D G3DSA:3.40.50.2000 173 317 6.9E-63 T 13-10-2018 TOPB45_0512 7ec405f21f07f97beadde3ab8d6f7aed 352 Gene3D G3DSA:3.40.50.2000 15 172 6.9E-63 T 13-10-2018 TOPB45_0512 7ec405f21f07f97beadde3ab8d6f7aed 352 SUPERFAMILY SSF53756 4 347 3.0E-51 T 13-10-2018 TOPB45_0565 261401844b66e1c537d86f69c07737b4 351 Gene3D G3DSA:3.30.420.40 26 348 6.8E-42 T 13-10-2018 TOPB45_0565 261401844b66e1c537d86f69c07737b4 351 Gene3D G3DSA:3.30.420.40 188 314 6.8E-42 T 13-10-2018 TOPB45_0565 261401844b66e1c537d86f69c07737b4 351 SUPERFAMILY SSF53067 187 315 1.05E-10 T 13-10-2018 TOPB45_0565 261401844b66e1c537d86f69c07737b4 351 Gene3D G3DSA:3.30.1490.300 99 150 6.8E-42 T 13-10-2018 TOPB45_0565 261401844b66e1c537d86f69c07737b4 351 Pfam PF11104 Type IV pilus assembly protein PilM; 27 350 1.0E-23 T 13-10-2018 IPR005883 Type IV pilus assembly protein PilM TOPB45_0940 a3789f60b74f7839acfba2ad727181ff 471 SUPERFAMILY SSF53623 115 315 1.07E-43 T 13-10-2018 IPR036565 Mur-like, catalytic domain superfamily GO:0005524|GO:0009058 Reactome: R-HSA-196757 TOPB45_0940 a3789f60b74f7839acfba2ad727181ff 471 Pfam PF01225 Mur ligase family, catalytic domain 30 107 1.4E-10 T 13-10-2018 IPR000713 Mur ligase, N-terminal catalytic domain GO:0005524|GO:0009058 TOPB45_0940 a3789f60b74f7839acfba2ad727181ff 471 Pfam PF02875 Mur ligase family, glutamate ligase domain 326 404 1.6E-17 T 13-10-2018 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 TOPB45_0940 a3789f60b74f7839acfba2ad727181ff 471 Pfam PF08245 Mur ligase middle domain 118 304 1.1E-42 T 13-10-2018 IPR013221 Mur ligase, central GO:0005524|GO:0009058 TOPB45_0940 a3789f60b74f7839acfba2ad727181ff 471 SUPERFAMILY SSF53244 327 466 1.1E-29 T 13-10-2018 IPR036615 Mur ligase, C-terminal domain superfamily GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 TOPB45_0940 a3789f60b74f7839acfba2ad727181ff 471 Gene3D G3DSA:3.40.1190.10 94 319 3.4E-57 T 13-10-2018 IPR036565 Mur-like, catalytic domain superfamily GO:0005524|GO:0009058 Reactome: R-HSA-196757 TOPB45_0940 a3789f60b74f7839acfba2ad727181ff 471 SUPERFAMILY SSF63418 7 110 1.31E-23 T 13-10-2018 IPR035911 MurE/MurF, N-terminal TOPB45_0940 a3789f60b74f7839acfba2ad727181ff 471 TIGRFAM TIGR01143 murF: UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase 34 466 1.1E-121 T 13-10-2018 IPR005863 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase GO:0005524|GO:0005737|GO:0047480|GO:0071555 KEGG: 00300+6.3.2.10|KEGG: 00550+6.3.2.10|MetaCyc: PWY-6386|MetaCyc: PWY-6387|MetaCyc: PWY-7953 TOPB45_0940 a3789f60b74f7839acfba2ad727181ff 471 Gene3D G3DSA:3.90.190.20 324 470 3.2E-39 T 13-10-2018 IPR036615 Mur ligase, C-terminal domain superfamily GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 TOPB45_0940 a3789f60b74f7839acfba2ad727181ff 471 Hamap MF_02019 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [murF]. 7 467 30.81 T 13-10-2018 IPR005863 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase GO:0005524|GO:0005737|GO:0047480|GO:0071555 KEGG: 00300+6.3.2.10|KEGG: 00550+6.3.2.10|MetaCyc: PWY-6386|MetaCyc: PWY-6387|MetaCyc: PWY-7953 TOPB45_0940 a3789f60b74f7839acfba2ad727181ff 471 Gene3D G3DSA:3.40.1390.10 4 85 5.4E-20 T 13-10-2018 TOPB45_1416 4ace228bba25bd692cbb1e09cc1a1ebf 86 ProDom PD028235 EXONUCLEASE SMALL SUBUNIT VII EXODEOXYRIBONUCLEASE HYDROLASE NUCLEASE PROBABLE VII SIMILAR 2 51 3.0E-6 T 13-10-2018 IPR003761 Exonuclease VII, small subunit GO:0006308|GO:0008855|GO:0009318 TOPB45_1416 4ace228bba25bd692cbb1e09cc1a1ebf 86 SUPERFAMILY SSF116842 3 68 5.89E-20 T 13-10-2018 TOPB45_1416 4ace228bba25bd692cbb1e09cc1a1ebf 86 Hamap MF_00337 Exodeoxyribonuclease 7 small subunit [xseB]. 9 69 15.052 T 13-10-2018 IPR003761 Exonuclease VII, small subunit GO:0006308|GO:0008855|GO:0009318 TOPB45_1416 4ace228bba25bd692cbb1e09cc1a1ebf 86 Pfam PF02609 Exonuclease VII small subunit 10 61 6.3E-19 T 13-10-2018 IPR003761 Exonuclease VII, small subunit GO:0006308|GO:0008855|GO:0009318 TOPB45_1416 4ace228bba25bd692cbb1e09cc1a1ebf 86 TIGRFAM TIGR01280 xseB: exodeoxyribonuclease VII, small subunit 9 64 7.1E-21 T 13-10-2018 IPR003761 Exonuclease VII, small subunit GO:0006308|GO:0008855|GO:0009318 TOPB45_1416 4ace228bba25bd692cbb1e09cc1a1ebf 86 Gene3D G3DSA:1.10.287.1040 4 79 1.6E-19 T 13-10-2018 IPR037004 Exonuclease VII, small subunit superfamily GO:0006308|GO:0008855|GO:0009318 TOPB45_0886 4efca409e1f389d831c02637902ce96a 305 SUPERFAMILY SSF56770 42 302 1.44E-94 T 13-10-2018 TOPB45_0886 4efca409e1f389d831c02637902ce96a 305 Gene3D G3DSA:3.40.50.700 37 216 4.1E-72 T 13-10-2018 IPR037024 [NiFe]-hydrogenase, small subunit, N-terminal domain superfamily TOPB45_0886 4efca409e1f389d831c02637902ce96a 305 Gene3D G3DSA:4.10.480.10 220 305 1.9E-38 T 13-10-2018 IPR037148 [NiFe]-hydrogenase, small subunit, C-terminal domain superfamily TOPB45_0886 4efca409e1f389d831c02637902ce96a 305 PIRSF PIRSF000310 1 305 7.8E-142 T 13-10-2018 IPR001821 [NiFe]-hydrogenase, small subunit GO:0008901|GO:0009375|GO:0051536|GO:0055114 TOPB45_0886 4efca409e1f389d831c02637902ce96a 305 TIGRFAM TIGR00391 hydA: hydrogenase (NiFe) small subunit (hydA) 7 301 1.7E-138 T 13-10-2018 IPR001821 [NiFe]-hydrogenase, small subunit GO:0008901|GO:0009375|GO:0051536|GO:0055114 TOPB45_0886 4efca409e1f389d831c02637902ce96a 305 PRINTS PR00614 Ni-Fe hydrogenase small subunit signature 275 288 1.2E-81 T 13-10-2018 TOPB45_0886 4efca409e1f389d831c02637902ce96a 305 PRINTS PR00614 Ni-Fe hydrogenase small subunit signature 38 60 1.2E-81 T 13-10-2018 TOPB45_0886 4efca409e1f389d831c02637902ce96a 305 PRINTS PR00614 Ni-Fe hydrogenase small subunit signature 247 273 1.2E-81 T 13-10-2018 TOPB45_0886 4efca409e1f389d831c02637902ce96a 305 PRINTS PR00614 Ni-Fe hydrogenase small subunit signature 61 85 1.2E-81 T 13-10-2018 TOPB45_0886 4efca409e1f389d831c02637902ce96a 305 PRINTS PR00614 Ni-Fe hydrogenase small subunit signature 179 202 1.2E-81 T 13-10-2018 TOPB45_0886 4efca409e1f389d831c02637902ce96a 305 PRINTS PR00614 Ni-Fe hydrogenase small subunit signature 107 130 1.2E-81 T 13-10-2018 TOPB45_0886 4efca409e1f389d831c02637902ce96a 305 PRINTS PR00614 Ni-Fe hydrogenase small subunit signature 150 174 1.2E-81 T 13-10-2018 TOPB45_0886 4efca409e1f389d831c02637902ce96a 305 PRINTS PR00614 Ni-Fe hydrogenase small subunit signature 223 241 1.2E-81 T 13-10-2018 TOPB45_0886 4efca409e1f389d831c02637902ce96a 305 PRINTS PR00614 Ni-Fe hydrogenase small subunit signature 205 222 1.2E-81 T 13-10-2018 TOPB45_0886 4efca409e1f389d831c02637902ce96a 305 Pfam PF14720 NiFe/NiFeSe hydrogenase small subunit C-terminal 218 301 9.1E-35 T 13-10-2018 IPR027394 Cytochrome-c3 hydrogenase, C-terminal TOPB45_0886 4efca409e1f389d831c02637902ce96a 305 TIGRFAM TIGR01409 TAT_signal_seq: Tat (twin-arginine translocation) pathway signal sequence 7 25 4.2E-4 T 13-10-2018 IPR019546 Twin-arginine translocation pathway, signal sequence, bacterial/archaeal TOPB45_0886 4efca409e1f389d831c02637902ce96a 305 Pfam PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 53 198 6.3E-35 T 13-10-2018 IPR006137 NADH:ubiquinone oxidoreductase-like, 20kDa subunit GO:0051536|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_1423 505d30173ad507e72f613eb9fe373ab0 285 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 94 105 - T 13-10-2018 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site TOPB45_1423 505d30173ad507e72f613eb9fe373ab0 285 Gene3D G3DSA:3.30.70.20 63 110 1.1E-10 T 13-10-2018 TOPB45_1423 505d30173ad507e72f613eb9fe373ab0 285 Pfam PF01656 CobQ/CobB/MinD/ParA nucleotide binding domain 4 261 1.8E-17 T 13-10-2018 IPR002586 CobQ/CobB/MinD/ParA nucleotide binding domain TOPB45_1423 505d30173ad507e72f613eb9fe373ab0 285 SUPERFAMILY SSF54862 58 116 3.63E-17 T 13-10-2018 TOPB45_1423 505d30173ad507e72f613eb9fe373ab0 285 SUPERFAMILY SSF52540 1 283 3.05E-33 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1423 505d30173ad507e72f613eb9fe373ab0 285 Pfam PF00037 4Fe-4S binding domain 62 84 3.1E-7 T 13-10-2018 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain TOPB45_1289 ecc02c751a8f5b4aa4594e0d7d16de29 265 Pfam PF03819 MazG nucleotide pyrophosphohydrolase domain 32 105 9.4E-24 T 13-10-2018 IPR004518 NTP pyrophosphohydrolase MazG, putative catalytic core TOPB45_1289 ecc02c751a8f5b4aa4594e0d7d16de29 265 Pfam PF03819 MazG nucleotide pyrophosphohydrolase domain 165 227 6.1E-9 T 13-10-2018 IPR004518 NTP pyrophosphohydrolase MazG, putative catalytic core TOPB45_1289 ecc02c751a8f5b4aa4594e0d7d16de29 265 SUPERFAMILY SSF101386 9 106 6.98E-23 T 13-10-2018 TOPB45_1289 ecc02c751a8f5b4aa4594e0d7d16de29 265 TIGRFAM TIGR00444 mazG: MazG family protein 16 257 4.3E-80 T 13-10-2018 IPR011551 NTP pyrophosphohydrolase MazG TOPB45_1289 ecc02c751a8f5b4aa4594e0d7d16de29 265 Gene3D G3DSA:1.10.287.1080 6 129 6.2E-39 T 13-10-2018 TOPB45_1289 ecc02c751a8f5b4aa4594e0d7d16de29 265 SUPERFAMILY SSF101386 137 236 5.61E-21 T 13-10-2018 TOPB45_1289 ecc02c751a8f5b4aa4594e0d7d16de29 265 Gene3D G3DSA:1.10.287.1080 131 260 1.3E-40 T 13-10-2018 TOPB45_1551 dd1a8784cf85f364a548eb3d04c6f3fc 141 Hamap MF_01398 ATP synthase subunit b [atpF]. 1 139 9.653 T 13-10-2018 IPR002146 ATP synthase, F0 complex, subunit b/b', bacterial/chloroplast GO:0015078|GO:0015986|GO:0045263 TOPB45_1551 dd1a8784cf85f364a548eb3d04c6f3fc 141 Pfam PF00430 ATP synthase B/B' CF(0) 7 137 2.6E-13 T 13-10-2018 IPR002146 ATP synthase, F0 complex, subunit b/b', bacterial/chloroplast GO:0015078|GO:0015986|GO:0045263 TOPB45_0085 9b2573e092ba18a70116a08d04fd5431 332 TIGRFAM TIGR00747 fabH: 3-oxoacyl-[acyl-carrier-protein] synthase III 7 332 1.3E-119 T 13-10-2018 IPR004655 3-oxoacyl-[acyl-carrier-protein] synthase 3 GO:0004315|GO:0006633 KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 TOPB45_0085 9b2573e092ba18a70116a08d04fd5431 332 Pfam PF08545 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III 111 191 1.9E-28 T 13-10-2018 IPR013751 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III GO:0004315|GO:0006633 KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 TOPB45_0085 9b2573e092ba18a70116a08d04fd5431 332 Gene3D G3DSA:3.40.47.10 4 332 1.1E-129 T 13-10-2018 IPR016039 Thiolase-like GO:0003824 TOPB45_0085 9b2573e092ba18a70116a08d04fd5431 332 SUPERFAMILY SSF53901 8 332 3.02E-64 T 13-10-2018 IPR016039 Thiolase-like GO:0003824 TOPB45_0085 9b2573e092ba18a70116a08d04fd5431 332 Hamap MF_01815 3-oxoacyl-[acyl-carrier-protein] synthase 3 [fabH]. 6 332 68.183 T 13-10-2018 IPR004655 3-oxoacyl-[acyl-carrier-protein] synthase 3 GO:0004315|GO:0006633 KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 TOPB45_0085 9b2573e092ba18a70116a08d04fd5431 332 Pfam PF08541 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal 243 332 3.8E-37 T 13-10-2018 IPR013747 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III, C-terminal KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 TOPB45_1185 7b05cc34da9afd98cc5c07f1ee88d222 113 SUPERFAMILY SSF54197 1 112 3.69E-42 T 13-10-2018 IPR036265 HIT-like superfamily TOPB45_1185 7b05cc34da9afd98cc5c07f1ee88d222 113 ProSitePatterns PS00892 HIT domain signature. 86 104 - T 13-10-2018 IPR019808 Histidine triad, conserved site TOPB45_1185 7b05cc34da9afd98cc5c07f1ee88d222 113 Gene3D G3DSA:3.30.428.10 1 113 3.5E-44 T 13-10-2018 IPR036265 HIT-like superfamily TOPB45_1185 7b05cc34da9afd98cc5c07f1ee88d222 113 Pfam PF01230 HIT domain 11 107 1.0E-29 T 13-10-2018 IPR001310 Histidine triad (HIT) protein TOPB45_1185 7b05cc34da9afd98cc5c07f1ee88d222 113 PRINTS PR00332 Histidine triad family signature 93 103 1.5E-19 T 13-10-2018 IPR001310 Histidine triad (HIT) protein TOPB45_1185 7b05cc34da9afd98cc5c07f1ee88d222 113 PRINTS PR00332 Histidine triad family signature 25 43 1.5E-19 T 13-10-2018 IPR001310 Histidine triad (HIT) protein TOPB45_1185 7b05cc34da9afd98cc5c07f1ee88d222 113 PRINTS PR00332 Histidine triad family signature 4 20 1.5E-19 T 13-10-2018 IPR001310 Histidine triad (HIT) protein TOPB45_1337 7fbf21ed3ee9d7e40b4fcdb60726cb5f 159 Pfam PF03748 Flagellar basal body-associated protein FliL 64 158 4.0E-22 T 13-10-2018 IPR005503 Flagellar basal body-associated protein FliL GO:0006935|GO:0009425|GO:0071973 TOPB45_1415 b2a754b0dfab42d11570f47a99828108 301 ProSitePatterns PS00444 Polyprenyl synthases signature 2. 220 232 - T 13-10-2018 IPR033749 Polyprenyl synthetase, conserved site TOPB45_1415 b2a754b0dfab42d11570f47a99828108 301 Gene3D G3DSA:1.10.600.10 5 301 1.0E-96 T 13-10-2018 IPR008949 Isoprenoid synthase domain superfamily TOPB45_1415 b2a754b0dfab42d11570f47a99828108 301 SUPERFAMILY SSF48576 7 294 3.29E-82 T 13-10-2018 IPR008949 Isoprenoid synthase domain superfamily TOPB45_1415 b2a754b0dfab42d11570f47a99828108 301 Pfam PF00348 Polyprenyl synthetase 40 272 2.0E-53 T 13-10-2018 IPR000092 Polyprenyl synthetase GO:0008299 TOPB45_1415 b2a754b0dfab42d11570f47a99828108 301 ProSitePatterns PS00723 Polyprenyl synthases signature 1. 86 102 - T 13-10-2018 IPR033749 Polyprenyl synthetase, conserved site TOPB45_1159 079b8a91dd1ce51dfb4975d4ed254691 414 Pfam PF00565 Staphylococcal nuclease homologue 339 412 2.2E-4 T 13-10-2018 IPR016071 Staphylococcal nuclease (SNase-like), OB-fold Reactome: R-HSA-6802952 TOPB45_1159 079b8a91dd1ce51dfb4975d4ed254691 414 SUPERFAMILY SSF53335 3 258 7.76E-55 T 13-10-2018 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TOPB45_1159 079b8a91dd1ce51dfb4975d4ed254691 414 Gene3D G3DSA:3.40.50.150 5 269 1.6E-73 T 13-10-2018 TOPB45_1159 079b8a91dd1ce51dfb4975d4ed254691 414 PRINTS PR00508 S21 class N4 adenine-specific DNA methyltransferase signature 237 257 1.6E-29 T 13-10-2018 IPR001091 Restriction/modification DNA-methylase GO:0003677|GO:0006306|GO:0008170 TOPB45_1159 079b8a91dd1ce51dfb4975d4ed254691 414 PRINTS PR00508 S21 class N4 adenine-specific DNA methyltransferase signature 60 80 1.6E-29 T 13-10-2018 IPR001091 Restriction/modification DNA-methylase GO:0003677|GO:0006306|GO:0008170 TOPB45_1159 079b8a91dd1ce51dfb4975d4ed254691 414 PRINTS PR00508 S21 class N4 adenine-specific DNA methyltransferase signature 195 212 1.6E-29 T 13-10-2018 IPR001091 Restriction/modification DNA-methylase GO:0003677|GO:0006306|GO:0008170 TOPB45_1159 079b8a91dd1ce51dfb4975d4ed254691 414 PRINTS PR00508 S21 class N4 adenine-specific DNA methyltransferase signature 214 232 1.6E-29 T 13-10-2018 IPR001091 Restriction/modification DNA-methylase GO:0003677|GO:0006306|GO:0008170 TOPB45_1159 079b8a91dd1ce51dfb4975d4ed254691 414 PRINTS PR00508 S21 class N4 adenine-specific DNA methyltransferase signature 22 36 1.6E-29 T 13-10-2018 IPR001091 Restriction/modification DNA-methylase GO:0003677|GO:0006306|GO:0008170 TOPB45_1159 079b8a91dd1ce51dfb4975d4ed254691 414 Gene3D G3DSA:2.40.50.90 299 413 7.8E-7 T 13-10-2018 IPR035437 SNase-like, OB-fold superfamily TOPB45_1159 079b8a91dd1ce51dfb4975d4ed254691 414 Pfam PF01555 DNA methylase 23 254 1.1E-48 T 13-10-2018 IPR002941 DNA methylase N-4/N-6 GO:0003677|GO:0006306|GO:0008170 TOPB45_1159 079b8a91dd1ce51dfb4975d4ed254691 414 SUPERFAMILY SSF50199 305 409 1.16E-9 T 13-10-2018 TOPB45_1159 079b8a91dd1ce51dfb4975d4ed254691 414 ProSitePatterns PS00093 N-4 cytosine-specific DNA methylases signature. 27 32 - T 13-10-2018 IPR017985 DNA methylase, N-4 cytosine-specific, conserved site GO:0003677|GO:0015667|GO:0090124 TOPB45_1126 6eed51c91a650738ac55f51aa48f7f2b 183 PIRSF PIRSF005785 1 181 7.4E-50 T 13-10-2018 IPR012091 Peptidase M54, archaemetzincin, archaeal/bacterial GO:0006508|GO:0008237|GO:0008270 TOPB45_1126 6eed51c91a650738ac55f51aa48f7f2b 183 Gene3D G3DSA:3.40.390.10 6 178 4.3E-49 T 13-10-2018 IPR024079 Metallopeptidase, catalytic domain superfamily GO:0008237 TOPB45_1126 6eed51c91a650738ac55f51aa48f7f2b 183 Pfam PF07998 Peptidase family M54 7 174 1.6E-27 T 13-10-2018 IPR012962 Peptidase M54, archaemetzincin GO:0008270 TOPB45_1126 6eed51c91a650738ac55f51aa48f7f2b 183 SUPERFAMILY SSF55486 68 167 9.24E-11 T 13-10-2018 TOPB45_1406 7c826932eabe2a7a491faebaa0450d35 413 Gene3D G3DSA:3.30.70.3340 21 151 3.2E-59 T 13-10-2018 TOPB45_1406 7c826932eabe2a7a491faebaa0450d35 413 SUPERFAMILY SSF55124 25 160 4.65E-52 T 13-10-2018 IPR036136 Nitrite/Sulfite reductase ferredoxin-like domain superfamily GO:0016491|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 TOPB45_1406 7c826932eabe2a7a491faebaa0450d35 413 Pfam PF01077 Nitrite and sulphite reductase 4Fe-4S domain 154 378 2.4E-39 T 13-10-2018 IPR006067 Nitrite/sulphite reductase 4Fe-4S domain GO:0016491|GO:0020037|GO:0051536|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 TOPB45_1406 7c826932eabe2a7a491faebaa0450d35 413 SUPERFAMILY SSF56014 152 391 1.18E-42 T 13-10-2018 TOPB45_1406 7c826932eabe2a7a491faebaa0450d35 413 Gene3D G3DSA:3.30.70.20 227 291 1.2E-98 T 13-10-2018 TOPB45_1406 7c826932eabe2a7a491faebaa0450d35 413 SUPERFAMILY SSF54862 205 288 6.9E-9 T 13-10-2018 TOPB45_1406 7c826932eabe2a7a491faebaa0450d35 413 Pfam PF00037 4Fe-4S binding domain 270 288 7.9E-5 T 13-10-2018 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain TOPB45_1406 7c826932eabe2a7a491faebaa0450d35 413 TIGRFAM TIGR02066 dsrB: sulfite reductase, dissimilatory-type beta subunit 51 398 8.0E-158 T 13-10-2018 IPR011808 Sulphite reductase, dissimilatory-type beta subunit GO:0006790|GO:0009055|GO:0018551|GO:0051539 KEGG: 00633+1.8.99.5|KEGG: 00920+1.8.99.5|MetaCyc: PWY-5306|MetaCyc: PWY-5360 TOPB45_1406 7c826932eabe2a7a491faebaa0450d35 413 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 276 287 - T 13-10-2018 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site TOPB45_1406 7c826932eabe2a7a491faebaa0450d35 413 Gene3D G3DSA:3.30.413.10 159 385 1.2E-98 T 13-10-2018 TOPB45_1406 7c826932eabe2a7a491faebaa0450d35 413 Pfam PF03460 Nitrite/Sulfite reductase ferredoxin-like half domain 74 137 3.7E-13 T 13-10-2018 IPR005117 Nitrite/Sulfite reductase ferredoxin-like domain GO:0016491|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 TOPB45_0551 6118bdf6a399391e35a27bf4ab616ecb 476 Pfam PF13435 Cytochrome c554 and c-prime 115 181 2.3E-6 T 13-10-2018 IPR023155 Cytochrome c-552/4 TOPB45_0551 6118bdf6a399391e35a27bf4ab616ecb 476 Gene3D G3DSA:1.10.780.10 13 141 4.8E-11 T 13-10-2018 TOPB45_0551 6118bdf6a399391e35a27bf4ab616ecb 476 Pfam PF13447 Seven times multi-haem cytochrome CxxCH 211 298 1.1E-18 T 13-10-2018 TOPB45_0551 6118bdf6a399391e35a27bf4ab616ecb 476 SUPERFAMILY SSF48695 20 463 5.1E-59 T 13-10-2018 IPR036280 Multiheme cytochrome superfamily TOPB45_0551 6118bdf6a399391e35a27bf4ab616ecb 476 Gene3D G3DSA:1.10.1130.10 146 247 1.4E-5 T 13-10-2018 TOPB45_1458 4922cee3f75ba31f23a70125ef754f2b 72 Pfam PF09723 Zinc ribbon domain 1 41 4.0E-14 T 13-10-2018 IPR013429 Putative regulatory protein, FmdB, Zinc ribbon domain TOPB45_1458 4922cee3f75ba31f23a70125ef754f2b 72 TIGRFAM TIGR02605 CxxC_CxxC_SSSS: putative regulatory protein, FmdB family 1 48 1.0E-15 T 13-10-2018 IPR013429 Putative regulatory protein, FmdB, Zinc ribbon domain TOPB45_1458 4922cee3f75ba31f23a70125ef754f2b 72 SMART SM00834 1 42 1.2E-14 T 13-10-2018 IPR013429 Putative regulatory protein, FmdB, Zinc ribbon domain TOPB45_0012 04533b03649229913c8c6d6e815a093b 522 Hamap MF_01966 NAD(P)H-hydrate epimerase [nnrE]. 5 219 27.026 T 13-10-2018 IPR004443 YjeF N-terminal domain MetaCyc: PWY-6938 TOPB45_0012 04533b03649229913c8c6d6e815a093b 522 Gene3D G3DSA:3.40.50.10260 2 226 7.0E-70 T 13-10-2018 IPR036652 YjeF N-terminal domain superfamily MetaCyc: PWY-6938 TOPB45_0012 04533b03649229913c8c6d6e815a093b 522 Pfam PF01256 Carbohydrate kinase 257 512 3.3E-54 T 13-10-2018 IPR000631 ATP-dependent (S)-NAD(P)H-hydrate dehydratase GO:0052855 Reactome: R-HSA-197264 TOPB45_0012 04533b03649229913c8c6d6e815a093b 522 SUPERFAMILY SSF53613 236 517 6.84E-69 T 13-10-2018 IPR029056 Ribokinase-like TOPB45_0012 04533b03649229913c8c6d6e815a093b 522 TIGRFAM TIGR00197 yjeF_nterm: YjeF family N-terminal domain 3 220 2.1E-51 T 13-10-2018 IPR004443 YjeF N-terminal domain MetaCyc: PWY-6938 TOPB45_0012 04533b03649229913c8c6d6e815a093b 522 SUPERFAMILY SSF64153 1 256 3.79E-65 T 13-10-2018 IPR036652 YjeF N-terminal domain superfamily MetaCyc: PWY-6938 TOPB45_0012 04533b03649229913c8c6d6e815a093b 522 TIGRFAM TIGR00196 yjeF_cterm: YjeF family C-terminal domain 238 515 4.3E-67 T 13-10-2018 IPR000631 ATP-dependent (S)-NAD(P)H-hydrate dehydratase GO:0052855 Reactome: R-HSA-197264 TOPB45_0012 04533b03649229913c8c6d6e815a093b 522 PIRSF PIRSF017184 1 521 3.3E-146 T 13-10-2018 IPR030677 Bifunctional NAD(P)H-hydrate repair enzyme Nnr GO:0052855 MetaCyc: PWY-6938 TOPB45_0012 04533b03649229913c8c6d6e815a093b 522 Gene3D G3DSA:3.40.1190.20 231 519 1.4E-79 T 13-10-2018 IPR029056 Ribokinase-like TOPB45_0012 04533b03649229913c8c6d6e815a093b 522 Hamap MF_01965 ADP-dependent (S)-NAD(P)H-hydrate dehydratase [nnrD]. 234 519 21.702 T 13-10-2018 IPR000631 ATP-dependent (S)-NAD(P)H-hydrate dehydratase GO:0052855 Reactome: R-HSA-197264 TOPB45_0012 04533b03649229913c8c6d6e815a093b 522 Pfam PF03853 YjeF-related protein N-terminus 25 198 9.6E-47 T 13-10-2018 IPR004443 YjeF N-terminal domain MetaCyc: PWY-6938 TOPB45_1125 6f8cd28e3c62e1100fcb282f910195a9 595 TIGRFAM TIGR00254 GGDEF: diguanylate cyclase (GGDEF) domain 433 592 3.7E-46 T 13-10-2018 IPR000160 GGDEF domain TOPB45_1125 6f8cd28e3c62e1100fcb282f910195a9 595 Gene3D G3DSA:3.30.70.270 424 594 2.7E-50 T 13-10-2018 TOPB45_1125 6f8cd28e3c62e1100fcb282f910195a9 595 Pfam PF00990 Diguanylate cyclase, GGDEF domain 435 588 1.1E-44 T 13-10-2018 IPR000160 GGDEF domain TOPB45_1125 6f8cd28e3c62e1100fcb282f910195a9 595 Pfam PF05228 CHASE4 domain 52 196 3.6E-26 T 13-10-2018 IPR007892 CHASE4 TOPB45_1125 6f8cd28e3c62e1100fcb282f910195a9 595 SUPERFAMILY SSF55073 440 592 8.63E-43 T 13-10-2018 IPR029787 Nucleotide cyclase TOPB45_1125 6f8cd28e3c62e1100fcb282f910195a9 595 SMART SM00267 424 594 4.7E-59 T 13-10-2018 IPR000160 GGDEF domain TOPB45_0271 4bbc7e8ac7037620cbca55a56a963d39 278 Pfam PF02621 Menaquinone biosynthesis 4 260 1.1E-49 T 13-10-2018 IPR003773 Menaquinone biosynthesis enzyme TOPB45_0271 4bbc7e8ac7037620cbca55a56a963d39 278 Hamap MF_00995 Chorismate dehydratase [mqnA]. 5 266 24.752 T 13-10-2018 IPR030868 Chorismate dehydratase GO:0009234|GO:0016829 KEGG: 00130+4.2.1.151|MetaCyc: PWY-7371|MetaCyc: PWY-7374 TOPB45_0271 4bbc7e8ac7037620cbca55a56a963d39 278 Gene3D G3DSA:3.40.190.10 76 180 1.3E-64 T 13-10-2018 TOPB45_0271 4bbc7e8ac7037620cbca55a56a963d39 278 SUPERFAMILY SSF53850 4 268 1.09E-59 T 13-10-2018 TOPB45_0271 4bbc7e8ac7037620cbca55a56a963d39 278 Gene3D G3DSA:3.40.190.10 6 253 1.3E-64 T 13-10-2018 TOPB45_1538 e4f77ef8e9125a2c307a364827f290f9 285 Pfam PF01618 MotA/TolQ/ExbB proton channel family 130 226 1.2E-8 T 13-10-2018 IPR002898 MotA/TolQ/ExbB proton channel TOPB45_1538 e4f77ef8e9125a2c307a364827f290f9 285 ProSitePatterns PS01307 Flagellar motor protein motA family signature. 206 223 - T 13-10-2018 IPR000540 Flagellar motor protein MotA, conserved site TOPB45_1538 e4f77ef8e9125a2c307a364827f290f9 285 TIGRFAM TIGR03818 MotA1: flagellar motor stator protein MotA 1 282 7.2E-109 T 13-10-2018 IPR022522 Flagellar motor stator, MotA TOPB45_1514 19b0d83ae0e214d43302cbe248142ad3 144 Pfam PF13237 4Fe-4S dicluster domain 79 127 4.8E-9 T 13-10-2018 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain TOPB45_1514 19b0d83ae0e214d43302cbe248142ad3 144 SUPERFAMILY SSF54862 69 134 2.39E-18 T 13-10-2018 TOPB45_1514 19b0d83ae0e214d43302cbe248142ad3 144 Gene3D G3DSA:3.30.70.20 81 133 1.3E-12 T 13-10-2018 TOPB45_1514 19b0d83ae0e214d43302cbe248142ad3 144 SUPERFAMILY SSF55021 7 76 7.85E-15 T 13-10-2018 TOPB45_1514 19b0d83ae0e214d43302cbe248142ad3 144 Gene3D G3DSA:3.30.70.260 4 78 1.1E-9 T 13-10-2018 TOPB45_1514 19b0d83ae0e214d43302cbe248142ad3 144 Pfam PF09383 NIL domain 9 73 1.7E-11 T 13-10-2018 IPR018449 NIL domain TOPB45_1514 19b0d83ae0e214d43302cbe248142ad3 144 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 86 97 - T 13-10-2018 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site TOPB45_1514 19b0d83ae0e214d43302cbe248142ad3 144 SMART SM00930 3 75 2.7E-13 T 13-10-2018 IPR018449 NIL domain TOPB45_0689 0b830c387330ce794499a677aefe3760 175 TIGRFAM TIGR00168 infC: translation initiation factor IF-3 11 172 6.8E-64 T 13-10-2018 IPR001288 Translation initiation factor 3 GO:0003743|GO:0006413 Reactome: R-HSA-5368286 TOPB45_0689 0b830c387330ce794499a677aefe3760 175 SUPERFAMILY SSF55200 87 174 3.53E-29 T 13-10-2018 IPR036788 Translation initiation factor 3 (IF-3), C-terminal domain superfamily GO:0006413 Reactome: R-HSA-5368286 TOPB45_0689 0b830c387330ce794499a677aefe3760 175 Gene3D G3DSA:3.10.20.80 5 79 2.2E-33 T 13-10-2018 IPR036787 Translation initiation factor 3 (IF-3), N-terminal domain superfamily GO:0003743|GO:0006413 Reactome: R-HSA-5368286 TOPB45_0689 0b830c387330ce794499a677aefe3760 175 Hamap MF_00080 Translation initiation factor IF-3 [infC]. 5 174 29.225 T 13-10-2018 IPR001288 Translation initiation factor 3 GO:0003743|GO:0006413 Reactome: R-HSA-5368286 TOPB45_0689 0b830c387330ce794499a677aefe3760 175 Pfam PF00707 Translation initiation factor IF-3, C-terminal domain 87 171 3.2E-33 T 13-10-2018 IPR019815 Translation initiation factor 3, C-terminal GO:0006413 Reactome: R-HSA-5368286 TOPB45_0689 0b830c387330ce794499a677aefe3760 175 Gene3D G3DSA:3.30.110.10 80 175 2.7E-33 T 13-10-2018 IPR036788 Translation initiation factor 3 (IF-3), C-terminal domain superfamily GO:0006413 Reactome: R-HSA-5368286 TOPB45_0689 0b830c387330ce794499a677aefe3760 175 Pfam PF05198 Translation initiation factor IF-3, N-terminal domain 11 80 3.9E-31 T 13-10-2018 IPR019814 Translation initiation factor 3, N-terminal GO:0003743|GO:0006413 Reactome: R-HSA-5368286 TOPB45_0689 0b830c387330ce794499a677aefe3760 175 SUPERFAMILY SSF54364 9 82 3.79E-29 T 13-10-2018 IPR036787 Translation initiation factor 3 (IF-3), N-terminal domain superfamily GO:0003743|GO:0006413 Reactome: R-HSA-5368286 TOPB45_0198 dddd7e6d9033d67c675e80abcba8f939 201 Gene3D G3DSA:3.30.1370.110 69 199 4.5E-35 T 13-10-2018 TOPB45_0198 dddd7e6d9033d67c675e80abcba8f939 201 SUPERFAMILY SSF160443 110 194 8.24E-14 T 13-10-2018 IPR036063 Smr domain superfamily TOPB45_0198 dddd7e6d9033d67c675e80abcba8f939 201 SMART SM00463 109 195 2.4E-10 T 13-10-2018 IPR002625 Smr domain TOPB45_0198 dddd7e6d9033d67c675e80abcba8f939 201 Pfam PF01713 Smr domain 112 194 5.7E-20 T 13-10-2018 IPR002625 Smr domain TOPB45_0784 2b8cbd97b39e06cd0e6fa3fc122ec442 431 TIGRFAM TIGR00115 tig: trigger factor 13 397 4.8E-87 T 13-10-2018 IPR005215 Trigger factor GO:0015031 TOPB45_0784 2b8cbd97b39e06cd0e6fa3fc122ec442 431 Gene3D G3DSA:1.10.3120.10 118 422 2.2E-54 T 13-10-2018 IPR037041 Trigger factor, C-terminal domain superfamily GO:0006457|GO:0015031 TOPB45_0784 2b8cbd97b39e06cd0e6fa3fc122ec442 431 PIRSF PIRSF003095 1 431 1.7E-86 T 13-10-2018 IPR005215 Trigger factor GO:0015031 TOPB45_0784 2b8cbd97b39e06cd0e6fa3fc122ec442 431 Gene3D G3DSA:3.10.50.40 153 251 2.2E-54 T 13-10-2018 TOPB45_0784 2b8cbd97b39e06cd0e6fa3fc122ec442 431 Pfam PF05697 Bacterial trigger factor protein (TF) 1 146 1.9E-30 T 13-10-2018 IPR008881 Trigger factor, ribosome-binding, bacterial GO:0006457|GO:0015031 TOPB45_0784 2b8cbd97b39e06cd0e6fa3fc122ec442 431 Hamap MF_00303 Trigger factor [tig]. 1 424 18.454 T 13-10-2018 IPR005215 Trigger factor GO:0015031 TOPB45_0784 2b8cbd97b39e06cd0e6fa3fc122ec442 431 SUPERFAMILY SSF109998 253 427 9.16E-31 T 13-10-2018 IPR027304 Trigger factor/SurA domain superfamily TOPB45_0784 2b8cbd97b39e06cd0e6fa3fc122ec442 431 SUPERFAMILY SSF102735 1 128 3.53E-27 T 13-10-2018 IPR036611 Trigger factor ribosome-binding domain superfamily GO:0006457|GO:0015031 TOPB45_0784 2b8cbd97b39e06cd0e6fa3fc122ec442 431 Gene3D G3DSA:3.30.70.1050 1 116 8.0E-28 T 13-10-2018 IPR036611 Trigger factor ribosome-binding domain superfamily GO:0006457|GO:0015031 TOPB45_0784 2b8cbd97b39e06cd0e6fa3fc122ec442 431 Pfam PF05698 Bacterial trigger factor protein (TF) C-terminus 267 399 2.9E-22 T 13-10-2018 IPR008880 Trigger factor, C-terminal GO:0006457|GO:0015031 TOPB45_0784 2b8cbd97b39e06cd0e6fa3fc122ec442 431 SUPERFAMILY SSF54534 135 252 3.05E-12 T 13-10-2018 TOPB45_0713 06dfa8abc4b77ef897fa533c584ed520 688 Pfam PF02436 Conserved carboxylase domain 314 549 2.0E-44 T 13-10-2018 IPR003379 Carboxylase, conserved domain Reactome: R-HSA-196780|Reactome: R-HSA-3371599|Reactome: R-HSA-70263 TOPB45_0713 06dfa8abc4b77ef897fa533c584ed520 688 Gene3D G3DSA:2.40.50.100 597 669 3.6E-20 T 13-10-2018 TOPB45_0713 06dfa8abc4b77ef897fa533c584ed520 688 Gene3D G3DSA:3.20.20.70 4 531 6.2E-108 T 13-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 TOPB45_0713 06dfa8abc4b77ef897fa533c584ed520 688 SUPERFAMILY SSF51569 23 310 1.17E-43 T 13-10-2018 TOPB45_0713 06dfa8abc4b77ef897fa533c584ed520 688 Pfam PF00364 Biotin-requiring enzyme 596 668 1.2E-12 T 13-10-2018 IPR000089 Biotin/lipoyl attachment TOPB45_0713 06dfa8abc4b77ef897fa533c584ed520 688 SUPERFAMILY SSF51230 592 668 7.98E-16 T 13-10-2018 IPR011053 Single hybrid motif TOPB45_0713 06dfa8abc4b77ef897fa533c584ed520 688 Pfam PF00682 HMGL-like 26 282 3.1E-11 T 13-10-2018 IPR000891 Pyruvate carboxyltransferase GO:0003824 TOPB45_0713 06dfa8abc4b77ef897fa533c584ed520 688 SUPERFAMILY SSF89000 319 532 3.49E-26 T 13-10-2018 TOPB45_0646 8fd5de68ef6d4374f72d47634520b90a 147 Pfam PF01842 ACT domain 74 123 3.8E-7 T 13-10-2018 IPR002912 ACT domain TOPB45_0646 8fd5de68ef6d4374f72d47634520b90a 147 SUPERFAMILY SSF55021 5 68 4.33E-14 T 13-10-2018 TOPB45_0646 8fd5de68ef6d4374f72d47634520b90a 147 SUPERFAMILY SSF55021 74 140 1.44E-11 T 13-10-2018 TOPB45_0646 8fd5de68ef6d4374f72d47634520b90a 147 Gene3D G3DSA:3.30.2130.10 2 144 2.0E-41 T 13-10-2018 TOPB45_0081 0d4ecde4444c362d73c92c538c550ebd 519 Gene3D G3DSA:3.60.15.10 264 517 4.8E-25 T 13-10-2018 IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like TOPB45_0081 0d4ecde4444c362d73c92c538c550ebd 519 SUPERFAMILY SSF55021 19 77 1.47E-7 T 13-10-2018 TOPB45_0081 0d4ecde4444c362d73c92c538c550ebd 519 SUPERFAMILY SSF55021 99 154 4.85E-6 T 13-10-2018 TOPB45_0081 0d4ecde4444c362d73c92c538c550ebd 519 Gene3D G3DSA:3.30.2130.10 15 162 4.1E-7 T 13-10-2018 TOPB45_0081 0d4ecde4444c362d73c92c538c550ebd 519 Pfam PF00753 Metallo-beta-lactamase superfamily 274 457 1.3E-13 T 13-10-2018 IPR001279 Metallo-beta-lactamase TOPB45_0081 0d4ecde4444c362d73c92c538c550ebd 519 SMART SM00849 277 509 1.9E-14 T 13-10-2018 IPR001279 Metallo-beta-lactamase TOPB45_0081 0d4ecde4444c362d73c92c538c550ebd 519 SUPERFAMILY SSF56281 275 513 4.06E-26 T 13-10-2018 IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like TOPB45_0360 8af74fb706f769adbe6cfc727b8b1a0a 250 Gene3D G3DSA:3.40.50.300 8 242 2.0E-6 T 13-10-2018 TOPB45_0769 535f552f4a0979f43aad629a2e8e13ac 129 Pfam PF00861 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast 9 129 1.2E-48 T 13-10-2018 IPR005484 Ribosomal protein L18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0769 535f552f4a0979f43aad629a2e8e13ac 129 Hamap MF_01337_B 50S ribosomal protein L18 [rplR]. 9 129 29.61 T 13-10-2018 IPR004389 Ribosomal protein L18, bacterial-type GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0769 535f552f4a0979f43aad629a2e8e13ac 129 TIGRFAM TIGR00060 L18_bact: ribosomal protein uL18 10 129 5.5E-42 T 13-10-2018 IPR004389 Ribosomal protein L18, bacterial-type GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0769 535f552f4a0979f43aad629a2e8e13ac 129 SUPERFAMILY SSF53137 10 127 1.13E-53 T 13-10-2018 TOPB45_0769 535f552f4a0979f43aad629a2e8e13ac 129 Gene3D G3DSA:3.30.420.100 8 129 1.2E-46 T 13-10-2018 TOPB45_1278 baa652a5a6e2a89455733f6e65582158 221 SMART SM00382 29 216 1.5E-10 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_1278 baa652a5a6e2a89455733f6e65582158 221 Pfam PF00005 ABC transporter 22 167 5.6E-36 T 13-10-2018 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TOPB45_1278 baa652a5a6e2a89455733f6e65582158 221 Gene3D G3DSA:3.40.50.300 1 221 1.4E-61 T 13-10-2018 TOPB45_1278 baa652a5a6e2a89455733f6e65582158 221 SUPERFAMILY SSF52540 3 219 8.3E-60 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1278 baa652a5a6e2a89455733f6e65582158 221 ProSitePatterns PS00211 ABC transporters family signature. 140 154 - T 13-10-2018 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TOPB45_0421 ba0150418b2a1744d31ffa753e5567ed 364 Pfam PF13353 4Fe-4S single cluster domain 23 129 5.5E-11 T 13-10-2018 TOPB45_0421 ba0150418b2a1744d31ffa753e5567ed 364 Pfam PF13186 Iron-sulfur cluster-binding domain 265 325 8.9E-6 T 13-10-2018 IPR023885 4Fe4S-binding SPASM domain TOPB45_0421 ba0150418b2a1744d31ffa753e5567ed 364 Gene3D G3DSA:3.20.20.70 15 335 1.6E-56 T 13-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 TOPB45_0421 ba0150418b2a1744d31ffa753e5567ed 364 SUPERFAMILY SSF102114 15 332 4.97E-75 T 13-10-2018 TOPB45_0421 ba0150418b2a1744d31ffa753e5567ed 364 SMART SM00729 16 216 8.3E-4 T 13-10-2018 IPR006638 Elp3/MiaB/NifB GO:0003824|GO:0051536 TOPB45_0421 ba0150418b2a1744d31ffa753e5567ed 364 TIGRFAM TIGR04085 rSAM_more_4Fe4S: radical SAM additional 4Fe4S-binding SPASM domain 265 351 2.1E-10 T 13-10-2018 IPR023885 4Fe4S-binding SPASM domain TOPB45_0421 ba0150418b2a1744d31ffa753e5567ed 364 Pfam PF04055 Radical SAM superfamily 21 177 7.6E-25 T 13-10-2018 IPR007197 Radical SAM GO:0003824|GO:0051536 TOPB45_0421 ba0150418b2a1744d31ffa753e5567ed 364 TIGRFAM TIGR04545 rSAM_ahbD_hemeb: heme b synthase 17 355 8.2E-162 T 13-10-2018 IPR030896 Heme b synthase TOPB45_0421 ba0150418b2a1744d31ffa753e5567ed 364 PIRSF PIRSF037420 3 364 6.3E-110 T 13-10-2018 IPR017200 Coenzyme PQQ synthesis protein E TOPB45_1138 914213149b9c8105743aa8626da1b3df 203 ProSitePatterns PS00760 Signal peptidases I lysine active site. 94 106 - T 13-10-2018 IPR019757 Peptidase S26A, signal peptidase I, lysine active site GO:0008236|GO:0016021 TOPB45_1138 914213149b9c8105743aa8626da1b3df 203 ProSitePatterns PS00501 Signal peptidases I serine active site. 37 44 - T 13-10-2018 IPR019756 Peptidase S26A, signal peptidase I, serine active site GO:0008236|GO:0016021 Reactome: R-HSA-1799339|Reactome: R-HSA-381771|Reactome: R-HSA-400511|Reactome: R-HSA-422085 TOPB45_1138 914213149b9c8105743aa8626da1b3df 203 SUPERFAMILY SSF51306 26 201 4.76E-62 T 13-10-2018 IPR036286 LexA/Signal peptidase-like superfamily TOPB45_1138 914213149b9c8105743aa8626da1b3df 203 TIGRFAM TIGR02227 sigpep_I_bact: signal peptidase I 11 186 1.4E-53 T 13-10-2018 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 TOPB45_1138 914213149b9c8105743aa8626da1b3df 203 PRINTS PR00727 Bacterial leader peptidase 1 (S26A) family signature 146 165 6.1E-23 T 13-10-2018 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 TOPB45_1138 914213149b9c8105743aa8626da1b3df 203 PRINTS PR00727 Bacterial leader peptidase 1 (S26A) family signature 28 44 6.1E-23 T 13-10-2018 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 TOPB45_1138 914213149b9c8105743aa8626da1b3df 203 PRINTS PR00727 Bacterial leader peptidase 1 (S26A) family signature 92 104 6.1E-23 T 13-10-2018 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 TOPB45_1138 914213149b9c8105743aa8626da1b3df 203 ProSitePatterns PS00761 Signal peptidases I signature 3. 151 164 - T 13-10-2018 IPR019758 Peptidase S26A, signal peptidase I, conserved site GO:0008236|GO:0016021 TOPB45_1138 914213149b9c8105743aa8626da1b3df 203 Pfam PF00717 Peptidase S24-like 34 116 5.4E-19 T 13-10-2018 IPR015927 Peptidase S24/S26A/S26B/S26C TOPB45_1384 c43a12655139fb530031b0ae42a6835b 415 Pfam PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 197 355 1.2E-28 T 13-10-2018 IPR020829 Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_1384 c43a12655139fb530031b0ae42a6835b 415 SUPERFAMILY SSF55347 192 345 1.25E-33 T 13-10-2018 TOPB45_1384 c43a12655139fb530031b0ae42a6835b 415 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 140 153 6.8E-17 T 13-10-2018 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_1384 c43a12655139fb530031b0ae42a6835b 415 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 322 337 6.8E-17 T 13-10-2018 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_1384 c43a12655139fb530031b0ae42a6835b 415 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 186 204 6.8E-17 T 13-10-2018 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_1384 c43a12655139fb530031b0ae42a6835b 415 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 277 294 6.8E-17 T 13-10-2018 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_1384 c43a12655139fb530031b0ae42a6835b 415 ProSitePatterns PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. 190 197 - T 13-10-2018 IPR020830 Glyceraldehyde 3-phosphate dehydrogenase, active site GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_1384 c43a12655139fb530031b0ae42a6835b 415 Pfam PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 10 125 4.6E-21 T 13-10-2018 IPR020828 Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_1384 c43a12655139fb530031b0ae42a6835b 415 SMART SM00846 9 192 1.3E-34 T 13-10-2018 IPR020828 Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_1384 c43a12655139fb530031b0ae42a6835b 415 Gene3D G3DSA:3.30.360.10 193 396 2.7E-101 T 13-10-2018 TOPB45_1384 c43a12655139fb530031b0ae42a6835b 415 SUPERFAMILY SSF51735 10 208 2.04E-37 T 13-10-2018 IPR036291 NAD(P)-binding domain superfamily TOPB45_1384 c43a12655139fb530031b0ae42a6835b 415 Gene3D G3DSA:3.40.50.720 10 407 2.7E-101 T 13-10-2018 TOPB45_0721 178bcb43b2c9a570d9fe86472ededc1a 490 TIGRFAM TIGR00435 cysS: cysteine--tRNA ligase 7 487 8.8E-167 T 13-10-2018 IPR015803 Cysteine-tRNA ligase GO:0004817|GO:0005524|GO:0006423 KEGG: 00970+6.1.1.16 TOPB45_0721 178bcb43b2c9a570d9fe86472ededc1a 490 SUPERFAMILY SSF47323 346 488 6.93E-25 T 13-10-2018 IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 TOPB45_0721 178bcb43b2c9a570d9fe86472ededc1a 490 Hamap MF_00041 Cysteine--tRNA ligase [cysS]. 7 490 37.635 T 13-10-2018 IPR015803 Cysteine-tRNA ligase GO:0004817|GO:0005524|GO:0006423 KEGG: 00970+6.1.1.16 TOPB45_0721 178bcb43b2c9a570d9fe86472ededc1a 490 Pfam PF09190 DALR domain 358 426 3.2E-9 T 13-10-2018 IPR015273 Cysteinyl-tRNA synthetase, class Ia, DALR GO:0000166|GO:0004817|GO:0005524|GO:0005737|GO:0006423 KEGG: 00970+6.1.1.16 TOPB45_0721 178bcb43b2c9a570d9fe86472ededc1a 490 Pfam PF01406 tRNA synthetases class I (C) catalytic domain 22 316 6.3E-132 T 13-10-2018 IPR032678 tRNA synthetases class I, catalytic domain KEGG: 00970+6.1.1.16 TOPB45_0721 178bcb43b2c9a570d9fe86472ededc1a 490 SMART SM00840 358 427 7.9E-8 T 13-10-2018 IPR015273 Cysteinyl-tRNA synthetase, class Ia, DALR GO:0000166|GO:0004817|GO:0005524|GO:0005737|GO:0006423 KEGG: 00970+6.1.1.16 TOPB45_0721 178bcb43b2c9a570d9fe86472ededc1a 490 Gene3D G3DSA:3.40.50.620 1 309 1.1E-137 T 13-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TOPB45_0721 178bcb43b2c9a570d9fe86472ededc1a 490 PRINTS PR00983 Cysteinyl-tRNA synthetase signature 66 75 1.2E-30 T 13-10-2018 IPR024909 Cysteinyl-tRNA synthetase/mycothiol ligase KEGG: 00970+6.1.1.16 TOPB45_0721 178bcb43b2c9a570d9fe86472ededc1a 490 PRINTS PR00983 Cysteinyl-tRNA synthetase signature 226 247 1.2E-30 T 13-10-2018 IPR024909 Cysteinyl-tRNA synthetase/mycothiol ligase KEGG: 00970+6.1.1.16 TOPB45_0721 178bcb43b2c9a570d9fe86472ededc1a 490 PRINTS PR00983 Cysteinyl-tRNA synthetase signature 30 41 1.2E-30 T 13-10-2018 IPR024909 Cysteinyl-tRNA synthetase/mycothiol ligase KEGG: 00970+6.1.1.16 TOPB45_0721 178bcb43b2c9a570d9fe86472ededc1a 490 PRINTS PR00983 Cysteinyl-tRNA synthetase signature 195 213 1.2E-30 T 13-10-2018 IPR024909 Cysteinyl-tRNA synthetase/mycothiol ligase KEGG: 00970+6.1.1.16 TOPB45_0721 178bcb43b2c9a570d9fe86472ededc1a 490 SUPERFAMILY SSF52374 7 317 1.51E-102 T 13-10-2018 TOPB45_0721 178bcb43b2c9a570d9fe86472ededc1a 490 Gene3D G3DSA:1.20.120.640 310 489 1.0E-31 T 13-10-2018 TOPB45_1504 9fed72b9679e8c4593b7950347a223f8 226 Pfam PF01487 Type I 3-dehydroquinase 3 218 5.5E-45 T 13-10-2018 IPR001381 3-dehydroquinate dehydratase type I GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 TOPB45_1504 9fed72b9679e8c4593b7950347a223f8 226 Hamap MF_00214 3-dehydroquinate dehydratase [aroD]. 1 221 26.964 T 13-10-2018 IPR001381 3-dehydroquinate dehydratase type I GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 TOPB45_1504 9fed72b9679e8c4593b7950347a223f8 226 Gene3D G3DSA:3.20.20.70 1 224 5.8E-47 T 13-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 TOPB45_1504 9fed72b9679e8c4593b7950347a223f8 226 SUPERFAMILY SSF51569 1 222 8.42E-47 T 13-10-2018 TOPB45_1109 ffb54f165932dda224a06407a2bb3e7c 803 Pfam PF01966 HD domain 7 101 5.9E-6 T 13-10-2018 IPR006674 HD domain TOPB45_1109 ffb54f165932dda224a06407a2bb3e7c 803 SUPERFAMILY SSF109604 9 102 4.28E-6 T 13-10-2018 TOPB45_1109 ffb54f165932dda224a06407a2bb3e7c 803 Gene3D G3DSA:1.10.3210.10 2 176 2.4E-12 T 13-10-2018 TOPB45_1109 ffb54f165932dda224a06407a2bb3e7c 803 TIGRFAM TIGR02578 cas_TM1811_Csm1: CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE 12 690 2.0E-111 T 13-10-2018 IPR013408 CRISPR-associated protein Csm1 TOPB45_1109 ffb54f165932dda224a06407a2bb3e7c 803 Gene3D G3DSA:3.30.70.2230 540 697 1.9E-37 T 13-10-2018 TOPB45_1163 c02baf75f6463d29cb42df570e5fb694 485 SMART SM00316 36 119 2.0E-7 T 13-10-2018 IPR022967 RNA-binding domain, S1 TOPB45_1163 c02baf75f6463d29cb42df570e5fb694 485 Gene3D G3DSA:2.40.50.140 31 125 9.4E-27 T 13-10-2018 TOPB45_1163 c02baf75f6463d29cb42df570e5fb694 485 TIGRFAM TIGR00757 RNaseEG: ribonuclease, Rne/Rng family 12 423 1.7E-153 T 13-10-2018 IPR004659 Ribonuclease E/G GO:0003723|GO:0004540|GO:0006396 TOPB45_1163 c02baf75f6463d29cb42df570e5fb694 485 Gene3D G3DSA:3.40.1260.20 399 485 1.2E-6 T 13-10-2018 TOPB45_1163 c02baf75f6463d29cb42df570e5fb694 485 Pfam PF10150 Ribonuclease E/G family 121 389 9.8E-106 T 13-10-2018 IPR019307 RNA-binding protein AU-1/Ribonuclease E/G GO:0003723 TOPB45_1163 c02baf75f6463d29cb42df570e5fb694 485 SUPERFAMILY SSF50249 38 124 1.47E-16 T 13-10-2018 IPR012340 Nucleic acid-binding, OB-fold TOPB45_0494 3239b3112475b80272e6c9798b52f70d 245 SUPERFAMILY SSF52467 4 244 1.25E-84 T 13-10-2018 IPR029035 DHS-like NAD/FAD-binding domain superfamily TOPB45_0494 3239b3112475b80272e6c9798b52f70d 245 Gene3D G3DSA:3.30.1600.10 31 165 2.2E-88 T 13-10-2018 IPR026591 Sirtuin, catalytic core small domain superfamily TOPB45_0494 3239b3112475b80272e6c9798b52f70d 245 Gene3D G3DSA:3.40.50.1220 6 228 2.2E-88 T 13-10-2018 TOPB45_0494 3239b3112475b80272e6c9798b52f70d 245 Pfam PF02146 Sir2 family 22 195 3.7E-53 T 13-10-2018 IPR003000 Sirtuin family GO:0070403 TOPB45_0951 8fb5e2b397a8df588bfd5655dc92327b 206 Hamap MF_00135 N-(5'-phosphoribosyl)anthranilate isomerase [trpF]. 2 204 33.506 T 13-10-2018 IPR001240 N-(5'phosphoribosyl) anthranilate isomerase (PRAI) GO:0004640|GO:0006568 KEGG: 00400+5.3.1.24 TOPB45_0951 8fb5e2b397a8df588bfd5655dc92327b 206 Gene3D G3DSA:3.20.20.70 1 204 3.7E-59 T 13-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 TOPB45_0951 8fb5e2b397a8df588bfd5655dc92327b 206 SUPERFAMILY SSF51366 3 202 1.57E-50 T 13-10-2018 IPR011060 Ribulose-phosphate binding barrel GO:0003824 TOPB45_0951 8fb5e2b397a8df588bfd5655dc92327b 206 Pfam PF00697 N-(5'phosphoribosyl)anthranilate (PRA) isomerase 4 199 4.1E-39 T 13-10-2018 IPR001240 N-(5'phosphoribosyl) anthranilate isomerase (PRAI) GO:0004640|GO:0006568 KEGG: 00400+5.3.1.24 TOPB45_0048 20743a12d1a454dffc1d28b8dc75de0a 233 Gene3D G3DSA:3.30.420.40 97 187 6.2E-34 T 13-10-2018 TOPB45_0048 20743a12d1a454dffc1d28b8dc75de0a 233 TIGRFAM TIGR03725 T6A_YeaZ: tRNA threonylcarbamoyl adenosine modification protein YeaZ 6 220 2.9E-32 T 13-10-2018 IPR022496 tRNA threonylcarbamoyl adenosine modification protein TsaB GO:0002949 TOPB45_0048 20743a12d1a454dffc1d28b8dc75de0a 233 Gene3D G3DSA:3.30.420.40 6 221 6.2E-34 T 13-10-2018 TOPB45_0048 20743a12d1a454dffc1d28b8dc75de0a 233 SUPERFAMILY SSF53067 5 105 5.7E-20 T 13-10-2018 TOPB45_0048 20743a12d1a454dffc1d28b8dc75de0a 233 Pfam PF00814 Glycoprotease family 37 147 1.9E-15 T 13-10-2018 IPR000905 Gcp-like domain TOPB45_1297 d55c3e7b69625afd975d2ec5758a191e 264 SMART SM00893 23 214 3.9E-40 T 13-10-2018 IPR014730 Electron transfer flavoprotein, alpha/beta-subunit, N-terminal Reactome: R-HSA-611105 TOPB45_1297 d55c3e7b69625afd975d2ec5758a191e 264 Gene3D G3DSA:3.40.50.620 3 263 1.2E-80 T 13-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TOPB45_1297 d55c3e7b69625afd975d2ec5758a191e 264 Pfam PF01012 Electron transfer flavoprotein domain 25 208 1.6E-37 T 13-10-2018 IPR014730 Electron transfer flavoprotein, alpha/beta-subunit, N-terminal Reactome: R-HSA-611105 TOPB45_1297 d55c3e7b69625afd975d2ec5758a191e 264 SUPERFAMILY SSF52402 3 258 4.54E-62 T 13-10-2018 TOPB45_1297 d55c3e7b69625afd975d2ec5758a191e 264 PIRSF PIRSF000090 2 263 1.0E-70 T 13-10-2018 IPR012255 Electron transfer flavoprotein, beta subunit GO:0009055 Reactome: R-HSA-611105|Reactome: R-HSA-8876725 TOPB45_0125 3553e441595cfcb6b685ab0d31b0079a 104 Pfam PF10865 Domain of unknown function (DUF2703) 14 97 5.5E-6 T 13-10-2018 IPR021219 Protein of unknown function DUF2703 TOPB45_0125 3553e441595cfcb6b685ab0d31b0079a 104 Gene3D G3DSA:3.40.30.10 1 65 4.2E-9 T 13-10-2018 TOPB45_0126 7d31ad4e4a476c70d10d66efd93d8818 345 Pfam PF02885 Glycosyl transferase family, helical bundle domain 4 64 3.6E-9 T 13-10-2018 IPR017459 Glycosyl transferase family 3, N-terminal domain Reactome: R-HSA-73614|Reactome: R-HSA-73621 TOPB45_0126 7d31ad4e4a476c70d10d66efd93d8818 345 SUPERFAMILY SSF52418 78 342 9.68E-83 T 13-10-2018 IPR035902 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain superfamily Reactome: R-HSA-73614|Reactome: R-HSA-73621 TOPB45_0126 7d31ad4e4a476c70d10d66efd93d8818 345 Pfam PF00591 Glycosyl transferase family, a/b domain 78 329 6.0E-82 T 13-10-2018 IPR000312 Glycosyl transferase, family 3 GO:0016757 Reactome: R-HSA-73614|Reactome: R-HSA-73621 TOPB45_0126 7d31ad4e4a476c70d10d66efd93d8818 345 Hamap MF_00211 Anthranilate phosphoribosyltransferase [trpD]. 5 339 34.242 T 13-10-2018 IPR005940 Anthranilate phosphoribosyl transferase GO:0000162|GO:0004048 KEGG: 00400+2.4.2.18 TOPB45_0126 7d31ad4e4a476c70d10d66efd93d8818 345 SUPERFAMILY SSF47648 3 69 1.22E-11 T 13-10-2018 IPR036320 Glycosyl transferase family 3, N-terminal domain superfamily Reactome: R-HSA-73614|Reactome: R-HSA-73621 TOPB45_0126 7d31ad4e4a476c70d10d66efd93d8818 345 Gene3D G3DSA:3.40.1030.10 71 322 2.3E-112 T 13-10-2018 IPR035902 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain superfamily Reactome: R-HSA-73614|Reactome: R-HSA-73621 TOPB45_0126 7d31ad4e4a476c70d10d66efd93d8818 345 TIGRFAM TIGR01245 trpD: anthranilate phosphoribosyltransferase 8 338 1.3E-108 T 13-10-2018 IPR005940 Anthranilate phosphoribosyl transferase GO:0000162|GO:0004048 KEGG: 00400+2.4.2.18 TOPB45_0126 7d31ad4e4a476c70d10d66efd93d8818 345 Gene3D G3DSA:1.20.970.10 7 187 2.3E-112 T 13-10-2018 TOPB45_0524 82d1f9d82926ad1ba962449a05da8096 322 Pfam PF00156 Phosphoribosyl transferase domain 226 292 4.3E-9 T 13-10-2018 IPR000836 Phosphoribosyltransferase domain GO:0009116 TOPB45_0524 82d1f9d82926ad1ba962449a05da8096 322 Gene3D G3DSA:3.40.50.2020 128 322 3.6E-48 T 13-10-2018 TOPB45_0524 82d1f9d82926ad1ba962449a05da8096 322 Hamap MF_01208 Orotate phosphoribosyltransferase [pyrE]. 86 322 21.583 T 13-10-2018 IPR023031 Orotate phosphoribosyltransferase GO:0004588|GO:0006221 KEGG: 00240+2.4.2.10|KEGG: 00983+2.4.2.10|MetaCyc: PWY-5686|MetaCyc: PWY-7790|MetaCyc: PWY-7791|Reactome: R-HSA-500753 TOPB45_0524 82d1f9d82926ad1ba962449a05da8096 322 TIGRFAM TIGR00336 pyrE: orotate phosphoribosyltransferase 152 309 1.1E-37 T 13-10-2018 IPR004467 Orotate phosphoribosyl transferase domain GO:0004588 KEGG: 00240+2.4.2.10|KEGG: 00983+2.4.2.10|MetaCyc: PWY-5686|MetaCyc: PWY-7790|MetaCyc: PWY-7791|Reactome: R-HSA-500753 TOPB45_0524 82d1f9d82926ad1ba962449a05da8096 322 SUPERFAMILY SSF141371 2 116 8.24E-19 T 13-10-2018 TOPB45_0524 82d1f9d82926ad1ba962449a05da8096 322 Pfam PF07238 PilZ domain 2 97 1.2E-11 T 13-10-2018 IPR009875 PilZ domain GO:0035438 TOPB45_0524 82d1f9d82926ad1ba962449a05da8096 322 SUPERFAMILY SSF53271 152 312 2.41E-32 T 13-10-2018 IPR029057 Phosphoribosyltransferase-like TOPB45_0524 82d1f9d82926ad1ba962449a05da8096 322 Gene3D G3DSA:2.40.10.220 1 118 6.0E-20 T 13-10-2018 TOPB45_0666 62d15138ec3b92c9e8329474ff5590ac 473 SUPERFAMILY SSF47384 245 318 1.33E-11 T 13-10-2018 IPR036097 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily GO:0000155|GO:0007165 TOPB45_0666 62d15138ec3b92c9e8329474ff5590ac 473 Gene3D G3DSA:1.10.287.130 239 319 3.8E-16 T 13-10-2018 TOPB45_0666 62d15138ec3b92c9e8329474ff5590ac 473 Gene3D G3DSA:3.30.565.10 322 472 4.0E-40 T 13-10-2018 IPR036890 Histidine kinase/HSP90-like ATPase superfamily TOPB45_0666 62d15138ec3b92c9e8329474ff5590ac 473 Pfam PF00512 His Kinase A (phospho-acceptor) domain 255 318 7.0E-9 T 13-10-2018 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TOPB45_0666 62d15138ec3b92c9e8329474ff5590ac 473 PRINTS PR00344 Bacterial sensor protein C-terminal signature 404 418 5.3E-19 T 13-10-2018 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TOPB45_0666 62d15138ec3b92c9e8329474ff5590ac 473 PRINTS PR00344 Bacterial sensor protein C-terminal signature 433 451 5.3E-19 T 13-10-2018 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TOPB45_0666 62d15138ec3b92c9e8329474ff5590ac 473 PRINTS PR00344 Bacterial sensor protein C-terminal signature 457 470 5.3E-19 T 13-10-2018 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TOPB45_0666 62d15138ec3b92c9e8329474ff5590ac 473 PRINTS PR00344 Bacterial sensor protein C-terminal signature 422 432 5.3E-19 T 13-10-2018 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 TOPB45_0666 62d15138ec3b92c9e8329474ff5590ac 473 SMART SM00304 188 240 2.2E-7 T 13-10-2018 IPR003660 HAMP domain GO:0007165|GO:0016021 TOPB45_0666 62d15138ec3b92c9e8329474ff5590ac 473 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 367 472 3.0E-18 T 13-10-2018 IPR003594 Histidine kinase/HSP90-like ATPase TOPB45_0666 62d15138ec3b92c9e8329474ff5590ac 473 SMART SM00387 365 473 8.2E-27 T 13-10-2018 IPR003594 Histidine kinase/HSP90-like ATPase TOPB45_0666 62d15138ec3b92c9e8329474ff5590ac 473 Pfam PF00672 HAMP domain 191 237 3.4E-9 T 13-10-2018 IPR003660 HAMP domain GO:0007165|GO:0016021 TOPB45_0666 62d15138ec3b92c9e8329474ff5590ac 473 Gene3D G3DSA:1.10.8.500 188 238 8.8E-13 T 13-10-2018 TOPB45_0666 62d15138ec3b92c9e8329474ff5590ac 473 SUPERFAMILY SSF55874 320 471 1.31E-37 T 13-10-2018 IPR036890 Histidine kinase/HSP90-like ATPase superfamily TOPB45_0666 62d15138ec3b92c9e8329474ff5590ac 473 SMART SM00388 253 322 3.2E-7 T 13-10-2018 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 TOPB45_0666 62d15138ec3b92c9e8329474ff5590ac 473 SUPERFAMILY SSF158472 190 237 1.7E-11 T 13-10-2018 TOPB45_0657 a825ff2bd69750bb105701f8756c4ab5 692 SMART SM00116 646 692 2.1E-11 T 13-10-2018 IPR000644 CBS domain TOPB45_0657 a825ff2bd69750bb105701f8756c4ab5 692 SMART SM00116 580 629 9.6E-8 T 13-10-2018 IPR000644 CBS domain TOPB45_0657 a825ff2bd69750bb105701f8756c4ab5 692 SMART SM00116 510 558 21.0 T 13-10-2018 IPR000644 CBS domain TOPB45_0657 a825ff2bd69750bb105701f8756c4ab5 692 SMART SM00116 448 495 0.032 T 13-10-2018 IPR000644 CBS domain TOPB45_0657 a825ff2bd69750bb105701f8756c4ab5 692 Pfam PF00571 CBS domain 449 494 3.3E-7 T 13-10-2018 IPR000644 CBS domain TOPB45_0657 a825ff2bd69750bb105701f8756c4ab5 692 Pfam PF00571 CBS domain 574 627 1.4E-9 T 13-10-2018 IPR000644 CBS domain TOPB45_0657 a825ff2bd69750bb105701f8756c4ab5 692 Pfam PF00571 CBS domain 639 692 4.5E-16 T 13-10-2018 IPR000644 CBS domain TOPB45_0657 a825ff2bd69750bb105701f8756c4ab5 692 SUPERFAMILY SSF54631 448 554 5.31E-16 T 13-10-2018 TOPB45_0657 a825ff2bd69750bb105701f8756c4ab5 692 SUPERFAMILY SSF54631 568 692 1.64E-35 T 13-10-2018 TOPB45_0657 a825ff2bd69750bb105701f8756c4ab5 692 ProSitePatterns PS00217 Sugar transport proteins signature 2. 124 149 - T 13-10-2018 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 TOPB45_0657 a825ff2bd69750bb105701f8756c4ab5 692 Gene3D G3DSA:3.10.580.10 564 692 1.5E-33 T 13-10-2018 TOPB45_0657 a825ff2bd69750bb105701f8756c4ab5 692 Gene3D G3DSA:1.20.1250.20 12 445 1.3E-56 T 13-10-2018 TOPB45_0657 a825ff2bd69750bb105701f8756c4ab5 692 Pfam PF00083 Sugar (and other) transporter 15 221 3.1E-18 T 13-10-2018 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 TOPB45_0657 a825ff2bd69750bb105701f8756c4ab5 692 SUPERFAMILY SSF103473 13 436 1.7E-60 T 13-10-2018 IPR036259 MFS transporter superfamily TOPB45_0657 a825ff2bd69750bb105701f8756c4ab5 692 Gene3D G3DSA:3.10.580.10 446 559 7.4E-15 T 13-10-2018 TOPB45_0657 a825ff2bd69750bb105701f8756c4ab5 692 Pfam PF07690 Major Facilitator Superfamily 265 442 3.4E-10 T 13-10-2018 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TOPB45_0346 639c89c082b7cd7083f6980da450e49f 394 Gene3D G3DSA:3.40.50.2000 1 217 3.4E-18 T 13-10-2018 TOPB45_0346 639c89c082b7cd7083f6980da450e49f 394 SUPERFAMILY SSF53756 1 393 8.97E-64 T 13-10-2018 TOPB45_0346 639c89c082b7cd7083f6980da450e49f 394 Pfam PF13439 Glycosyltransferase Family 4 16 191 5.4E-11 T 13-10-2018 IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain Reactome: R-HSA-446193|Reactome: R-HSA-4549349 TOPB45_0346 639c89c082b7cd7083f6980da450e49f 394 Pfam PF00534 Glycosyl transferases group 1 216 356 1.5E-29 T 13-10-2018 IPR001296 Glycosyl transferase, family 1 TOPB45_0346 639c89c082b7cd7083f6980da450e49f 394 Gene3D G3DSA:3.40.50.2000 218 373 2.4E-33 T 13-10-2018 TOPB45_1069 411306db8b6aa7ee2dac7d3816726487 225 Gene3D G3DSA:3.40.50.300 3 225 1.2E-69 T 13-10-2018 TOPB45_1069 411306db8b6aa7ee2dac7d3816726487 225 Pfam PF00005 ABC transporter 25 173 1.3E-32 T 13-10-2018 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TOPB45_1069 411306db8b6aa7ee2dac7d3816726487 225 SMART SM00382 34 220 4.0E-14 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_1069 411306db8b6aa7ee2dac7d3816726487 225 ProSitePatterns PS00211 ABC transporters family signature. 146 160 - T 13-10-2018 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TOPB45_1069 411306db8b6aa7ee2dac7d3816726487 225 SUPERFAMILY SSF52540 6 224 1.77E-73 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0313 c5256cb55ac0558015010977b300a070 211 SUPERFAMILY SSF51391 3 208 1.16E-61 T 13-10-2018 IPR036206 Thiamin phosphate synthase superfamily KEGG: 00730+2.5.1.3|MetaCyc: PWY-6893|MetaCyc: PWY-6894|MetaCyc: PWY-6897|MetaCyc: PWY-6907|MetaCyc: PWY-6908|MetaCyc: PWY-7356|MetaCyc: PWY-7357 TOPB45_0313 c5256cb55ac0558015010977b300a070 211 Pfam PF02581 Thiamine monophosphate synthase 6 188 2.6E-55 T 13-10-2018 IPR022998 Thiamine phosphate synthase/TenI KEGG: 00730+2.5.1.3|MetaCyc: PWY-6893|MetaCyc: PWY-6894|MetaCyc: PWY-6897|MetaCyc: PWY-6907|MetaCyc: PWY-6908|MetaCyc: PWY-7356|MetaCyc: PWY-7357 TOPB45_0313 c5256cb55ac0558015010977b300a070 211 TIGRFAM TIGR00693 thiE: thiamine-phosphate diphosphorylase 6 200 7.5E-58 T 13-10-2018 IPR034291 Thiamine phosphate synthase GO:0004789|GO:0009228 KEGG: 00730+2.5.1.3|MetaCyc: PWY-6893|MetaCyc: PWY-6894|MetaCyc: PWY-6897|MetaCyc: PWY-6907|MetaCyc: PWY-6908|MetaCyc: PWY-7356|MetaCyc: PWY-7357 TOPB45_0313 c5256cb55ac0558015010977b300a070 211 Hamap MF_00097 Thiamine-phosphate synthase [thiE]. 3 206 25.199 T 13-10-2018 IPR034291 Thiamine phosphate synthase GO:0004789|GO:0009228 KEGG: 00730+2.5.1.3|MetaCyc: PWY-6893|MetaCyc: PWY-6894|MetaCyc: PWY-6897|MetaCyc: PWY-6907|MetaCyc: PWY-6908|MetaCyc: PWY-7356|MetaCyc: PWY-7357 TOPB45_0313 c5256cb55ac0558015010977b300a070 211 Gene3D G3DSA:3.20.20.70 2 208 2.5E-60 T 13-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 TOPB45_1233 905ff65534741f181644b7be4beaf686 105 Gene3D G3DSA:3.30.460.10 1 105 9.1E-19 T 13-10-2018 TOPB45_1233 905ff65534741f181644b7be4beaf686 105 SUPERFAMILY SSF81301 4 105 2.73E-16 T 13-10-2018 TOPB45_1233 905ff65534741f181644b7be4beaf686 105 Pfam PF01909 Nucleotidyltransferase domain 6 100 8.5E-12 T 13-10-2018 IPR002934 Polymerase, nucleotidyl transferase domain GO:0016779 TOPB45_1349 64a8febf51153aab2759cc061ce8bad2 528 Gene3D G3DSA:1.25.40.10 318 518 9.8E-34 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_1349 64a8febf51153aab2759cc061ce8bad2 528 Gene3D G3DSA:1.25.40.10 17 317 3.6E-40 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_1349 64a8febf51153aab2759cc061ce8bad2 528 Pfam PF13181 Tetratricopeptide repeat 274 300 0.03 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_1349 64a8febf51153aab2759cc061ce8bad2 528 Pfam PF13181 Tetratricopeptide repeat 172 203 1.1E-4 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_1349 64a8febf51153aab2759cc061ce8bad2 528 Pfam PF14559 Tetratricopeptide repeat 47 112 6.1E-10 T 13-10-2018 TOPB45_1349 64a8febf51153aab2759cc061ce8bad2 528 SMART SM00028 408 442 83.0 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_1349 64a8febf51153aab2759cc061ce8bad2 528 SMART SM00028 478 511 2.7 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_1349 64a8febf51153aab2759cc061ce8bad2 528 SMART SM00028 103 136 200.0 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_1349 64a8febf51153aab2759cc061ce8bad2 528 SMART SM00028 137 170 1.7 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_1349 64a8febf51153aab2759cc061ce8bad2 528 SMART SM00028 69 102 60.0 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_1349 64a8febf51153aab2759cc061ce8bad2 528 SMART SM00028 38 68 340.0 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_1349 64a8febf51153aab2759cc061ce8bad2 528 SMART SM00028 171 204 0.0045 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_1349 64a8febf51153aab2759cc061ce8bad2 528 SMART SM00028 443 476 1.6E-4 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_1349 64a8febf51153aab2759cc061ce8bad2 528 SMART SM00028 273 306 19.0 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_1349 64a8febf51153aab2759cc061ce8bad2 528 SUPERFAMILY SSF48452 26 123 8.22E-8 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_1349 64a8febf51153aab2759cc061ce8bad2 528 SUPERFAMILY SSF48452 100 300 5.56E-24 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_1349 64a8febf51153aab2759cc061ce8bad2 528 Pfam PF13432 Tetratricopeptide repeat 417 476 1.9E-7 T 13-10-2018 TOPB45_1349 64a8febf51153aab2759cc061ce8bad2 528 Pfam PF13176 Tetratricopeptide repeat 483 507 0.0013 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_1349 64a8febf51153aab2759cc061ce8bad2 528 SUPERFAMILY SSF48452 337 506 5.5E-25 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_0545 7bcb5eeb8505fd2cb8e610fd277603e4 337 Gene3D G3DSA:3.30.930.10 10 337 2.2E-117 T 13-10-2018 TOPB45_0545 7bcb5eeb8505fd2cb8e610fd277603e4 337 Hamap MF_00281 Phenylalanine--tRNA ligase alpha subunit [pheS]. 10 336 45.512 T 13-10-2018 IPR022911 Phenylalanine-tRNA ligase alpha chain 1, bacterial GO:0004826 KEGG: 00970+6.1.1.20 TOPB45_0545 7bcb5eeb8505fd2cb8e610fd277603e4 337 Pfam PF01409 tRNA synthetases class II core domain (F) 91 336 3.2E-100 T 13-10-2018 IPR002319 Phenylalanyl-tRNA synthetase GO:0000049|GO:0004812|GO:0005524|GO:0005737|GO:0043039 KEGG: 00970+6.1.1.20 TOPB45_0545 7bcb5eeb8505fd2cb8e610fd277603e4 337 SUPERFAMILY SSF55681 91 337 1.63E-79 T 13-10-2018 TOPB45_0545 7bcb5eeb8505fd2cb8e610fd277603e4 337 Pfam PF02912 Aminoacyl tRNA synthetase class II, N-terminal domain 22 87 9.8E-18 T 13-10-2018 IPR004188 Phenylalanine-tRNA ligase, class II, N-terminal GO:0000166|GO:0004826|GO:0005524|GO:0005737|GO:0006432 KEGG: 00970+6.1.1.20 TOPB45_0545 7bcb5eeb8505fd2cb8e610fd277603e4 337 SUPERFAMILY SSF46589 17 98 1.78E-16 T 13-10-2018 IPR010978 Class I and II aminoacyl-tRNA synthetase, tRNA-binding arm GO:0000166 TOPB45_0545 7bcb5eeb8505fd2cb8e610fd277603e4 337 TIGRFAM TIGR00468 pheS: phenylalanine--tRNA ligase, alpha subunit 42 337 2.1E-100 T 13-10-2018 IPR004529 Phenylalanyl-tRNA synthetase, class IIc, alpha subunit GO:0000166|GO:0004826|GO:0005524|GO:0005737|GO:0006432 KEGG: 00970+6.1.1.20|Reactome: R-HSA-379716 TOPB45_0312 7e70bc35b5ec5d7ab776886e245fae41 230 Pfam PF13353 4Fe-4S single cluster domain 15 110 1.4E-10 T 13-10-2018 TOPB45_0312 7e70bc35b5ec5d7ab776886e245fae41 230 Gene3D G3DSA:3.20.20.70 1 225 3.7E-31 T 13-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 TOPB45_0312 7e70bc35b5ec5d7ab776886e245fae41 230 SMART SM00729 16 219 1.6E-4 T 13-10-2018 IPR006638 Elp3/MiaB/NifB GO:0003824|GO:0051536 TOPB45_0312 7e70bc35b5ec5d7ab776886e245fae41 230 TIGRFAM TIGR02495 NrdG2: anaerobic ribonucleoside-triphosphate reductase activating protein 2 190 1.5E-48 T 13-10-2018 IPR012840 Anaerobic ribonucleoside-triphosphate reductase activating protein TOPB45_0312 7e70bc35b5ec5d7ab776886e245fae41 230 SUPERFAMILY SSF102114 12 223 7.72E-27 T 13-10-2018 TOPB45_0312 7e70bc35b5ec5d7ab776886e245fae41 230 Pfam PF04055 Radical SAM superfamily 22 165 1.1E-16 T 13-10-2018 IPR007197 Radical SAM GO:0003824|GO:0051536 TOPB45_0057 446e5b6b33dd97294227b47eb8273e21 131 ProSitePatterns PS00588 Flagella basal body rod proteins signature. 15 35 - T 13-10-2018 IPR019776 Flagellar basal body rod protein, conserved site TOPB45_0057 446e5b6b33dd97294227b47eb8273e21 131 TIGRFAM TIGR01396 FlgB: flagellar basal-body rod protein FlgB 5 126 1.0E-26 T 13-10-2018 IPR006300 Flagellar basal-body rod protein FlgB GO:0030694|GO:0071973 TOPB45_0057 446e5b6b33dd97294227b47eb8273e21 131 Pfam PF00460 Flagella basal body rod protein 26 39 5.9E-5 T 13-10-2018 IPR001444 Flagellar basal body rod protein, N-terminal GO:0071973 TOPB45_0057 446e5b6b33dd97294227b47eb8273e21 131 PIRSF PIRSF002889 1 129 1.8E-29 T 13-10-2018 IPR006300 Flagellar basal-body rod protein FlgB GO:0030694|GO:0071973 TOPB45_1179 500079036460f4e27271b0553ee2613c 105 SUPERFAMILY SSF50037 51 101 5.04E-10 T 13-10-2018 IPR008988 Transcriptional repressor, C-terminal TOPB45_1179 500079036460f4e27271b0553ee2613c 105 Pfam PF04023 FeoA domain 9 101 2.7E-14 T 13-10-2018 IPR007167 Ferrous iron transporter FeoA domain GO:0046914 TOPB45_1179 500079036460f4e27271b0553ee2613c 105 SMART SM00899 9 103 1.9E-9 T 13-10-2018 IPR007167 Ferrous iron transporter FeoA domain GO:0046914 TOPB45_1179 500079036460f4e27271b0553ee2613c 105 Gene3D G3DSA:2.30.30.90 47 103 3.4E-12 T 13-10-2018 IPR038157 Ferrous iron transporter, core domain TOPB45_0310 f01c1dac06be93ca56eb9f8bb9da8b48 470 SUPERFAMILY SSF56935 92 470 3.04E-12 T 13-10-2018 TOPB45_0879 0e96dbd1c171ecae7ae8af73b03bb5a4 250 Hamap MF_01393 ATP synthase subunit a [atpB]. 1 249 13.561 T 13-10-2018 IPR000568 ATP synthase, F0 complex, subunit A GO:0015078|GO:0015986|GO:0045263 Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_0879 0e96dbd1c171ecae7ae8af73b03bb5a4 250 TIGRFAM TIGR01131 ATP_synt_6_or_A: ATP synthase F0, A subunit 42 243 1.7E-34 T 13-10-2018 IPR000568 ATP synthase, F0 complex, subunit A GO:0015078|GO:0015986|GO:0045263 Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_0879 0e96dbd1c171ecae7ae8af73b03bb5a4 250 SUPERFAMILY SSF81336 99 242 1.83E-29 T 13-10-2018 IPR035908 ATP synthase, F0 complex, subunit A superfamily Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_0879 0e96dbd1c171ecae7ae8af73b03bb5a4 250 PRINTS PR00123 ATP synthase A subunit signature 164 179 1.9E-13 T 13-10-2018 IPR000568 ATP synthase, F0 complex, subunit A GO:0015078|GO:0015986|GO:0045263 Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_0879 0e96dbd1c171ecae7ae8af73b03bb5a4 250 PRINTS PR00123 ATP synthase A subunit signature 229 244 1.9E-13 T 13-10-2018 IPR000568 ATP synthase, F0 complex, subunit A GO:0015078|GO:0015986|GO:0045263 Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_0879 0e96dbd1c171ecae7ae8af73b03bb5a4 250 PRINTS PR00123 ATP synthase A subunit signature 105 121 1.9E-13 T 13-10-2018 IPR000568 ATP synthase, F0 complex, subunit A GO:0015078|GO:0015986|GO:0045263 Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_0879 0e96dbd1c171ecae7ae8af73b03bb5a4 250 PRINTS PR00123 ATP synthase A subunit signature 184 206 1.9E-13 T 13-10-2018 IPR000568 ATP synthase, F0 complex, subunit A GO:0015078|GO:0015986|GO:0045263 Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_0879 0e96dbd1c171ecae7ae8af73b03bb5a4 250 Pfam PF00119 ATP synthase A chain 43 242 7.8E-46 T 13-10-2018 IPR000568 ATP synthase, F0 complex, subunit A GO:0015078|GO:0015986|GO:0045263 Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_0879 0e96dbd1c171ecae7ae8af73b03bb5a4 250 ProSitePatterns PS00449 ATP synthase a subunit signature. 187 196 - T 13-10-2018 IPR023011 ATP synthase, F0 complex, subunit A, active site Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_0879 0e96dbd1c171ecae7ae8af73b03bb5a4 250 Gene3D G3DSA:1.20.120.220 99 249 5.6E-34 T 13-10-2018 IPR035908 ATP synthase, F0 complex, subunit A superfamily Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_0070 76051dc5d0769a5749768ec24e1a651f 277 ProSitePatterns PS01242 Zinc finger FPG-type signature. 251 275 - T 13-10-2018 IPR015887 DNA glycosylase/AP lyase, zinc finger domain, DNA-binding site GO:0003677|GO:0003906|GO:0006281|GO:0008270|GO:0016799 TOPB45_0070 76051dc5d0769a5749768ec24e1a651f 277 SMART SM01232 138 228 4.8E-31 T 13-10-2018 IPR015886 DNA glycosylase/AP lyase, H2TH DNA-binding GO:0003684|GO:0003906|GO:0006289|GO:0008270|GO:0016799 TOPB45_0070 76051dc5d0769a5749768ec24e1a651f 277 SUPERFAMILY SSF81624 2 147 5.89E-24 T 13-10-2018 IPR035937 MutM-like, N-terminal TOPB45_0070 76051dc5d0769a5749768ec24e1a651f 277 SMART SM00898 2 122 1.2E-23 T 13-10-2018 IPR012319 Formamidopyrimidine-DNA glycosylase, catalytic domain GO:0003684|GO:0003906|GO:0006284|GO:0008270|GO:0016799 TOPB45_0070 76051dc5d0769a5749768ec24e1a651f 277 SUPERFAMILY SSF46946 138 225 4.97E-24 T 13-10-2018 IPR010979 Ribosomal protein S13-like, H2TH GO:0003676 TOPB45_0070 76051dc5d0769a5749768ec24e1a651f 277 Pfam PF01149 Formamidopyrimidine-DNA glycosylase N-terminal domain 1 121 1.5E-22 T 13-10-2018 IPR012319 Formamidopyrimidine-DNA glycosylase, catalytic domain GO:0003684|GO:0003906|GO:0006284|GO:0008270|GO:0016799 TOPB45_0070 76051dc5d0769a5749768ec24e1a651f 277 Gene3D G3DSA:3.20.190.10 1 139 5.2E-30 T 13-10-2018 IPR035937 MutM-like, N-terminal TOPB45_0070 76051dc5d0769a5749768ec24e1a651f 277 SUPERFAMILY SSF57716 224 275 4.28E-14 T 13-10-2018 TOPB45_0070 76051dc5d0769a5749768ec24e1a651f 277 TIGRFAM TIGR00577 fpg: DNA-formamidopyrimidine glycosylase 1 275 4.1E-76 T 13-10-2018 IPR020629 Formamidopyrimidine-DNA glycosylase GO:0003906|GO:0006281|GO:0008270|GO:0008534 TOPB45_0070 76051dc5d0769a5749768ec24e1a651f 277 Gene3D G3DSA:1.10.8.50 141 276 2.6E-44 T 13-10-2018 TOPB45_0070 76051dc5d0769a5749768ec24e1a651f 277 Pfam PF06831 Formamidopyrimidine-DNA glycosylase H2TH domain 142 225 6.9E-24 T 13-10-2018 IPR015886 DNA glycosylase/AP lyase, H2TH DNA-binding GO:0003684|GO:0003906|GO:0006289|GO:0008270|GO:0016799 TOPB45_0286 d7f8b77ce1eb4029235360a604c33d3a 442 Gene3D G3DSA:3.20.20.540 43 365 6.2E-149 T 13-10-2018 IPR038521 ThiC/Bza superfamily KEGG: 00730+4.1.99.17|MetaCyc: PWY-6890 TOPB45_0286 d7f8b77ce1eb4029235360a604c33d3a 442 TIGRFAM TIGR00190 thiC: phosphomethylpyrimidine synthase 7 425 1.8E-194 T 13-10-2018 IPR002817 Phosphomethylpyrimidine synthase ThiC/5-hydroxybenzimidazole synthase BzaA/B GO:0009228|GO:0051536 KEGG: 00730+4.1.99.17|MetaCyc: PWY-6890 TOPB45_0286 d7f8b77ce1eb4029235360a604c33d3a 442 Pfam PF01964 Radical SAM ThiC family 5 424 1.5E-198 T 13-10-2018 IPR002817 Phosphomethylpyrimidine synthase ThiC/5-hydroxybenzimidazole synthase BzaA/B GO:0009228|GO:0051536 KEGG: 00730+4.1.99.17|MetaCyc: PWY-6890 TOPB45_0286 d7f8b77ce1eb4029235360a604c33d3a 442 Hamap MF_00089 Phosphomethylpyrimidine synthase [thiC]. 2 429 89.153 T 13-10-2018 IPR037509 Phosphomethylpyrimidine synthase GO:0009228|GO:0016830 KEGG: 00730+4.1.99.17|MetaCyc: PWY-6890 TOPB45_0681 d766d6579715cbca46dd5788cab078b9 399 Pfam PF00155 Aminotransferase class I and II 32 391 7.8E-68 T 13-10-2018 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 TOPB45_0681 d766d6579715cbca46dd5788cab078b9 399 SUPERFAMILY SSF53383 1 397 5.45E-117 T 13-10-2018 IPR015424 Pyridoxal phosphate-dependent transferase TOPB45_0681 d766d6579715cbca46dd5788cab078b9 399 Gene3D G3DSA:3.90.1150.10 26 390 2.2E-134 T 13-10-2018 IPR015422 Pyridoxal phosphate-dependent transferase domain 1 GO:0003824 TOPB45_0681 d766d6579715cbca46dd5788cab078b9 399 Gene3D G3DSA:3.40.640.10 63 285 2.2E-134 T 13-10-2018 IPR015421 Pyridoxal phosphate-dependent transferase, major domain GO:0003824 TOPB45_0681 d766d6579715cbca46dd5788cab078b9 399 ProSitePatterns PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 235 248 - T 13-10-2018 IPR004838 Aminotransferases, class-I, pyridoxal-phosphate-binding site GO:0003824|GO:0009058|GO:0030170 TOPB45_0982 697f92ccd9f6080daec6c55d35fba211 207 Gene3D G3DSA:3.30.420.10 7 207 1.0E-71 T 13-10-2018 IPR036397 Ribonuclease H superfamily GO:0003676 TOPB45_0982 697f92ccd9f6080daec6c55d35fba211 207 Hamap MF_00052_B Ribonuclease HII [rnhB]. 25 205 33.957 T 13-10-2018 IPR022898 Ribonuclease HII GO:0004523 TOPB45_0982 697f92ccd9f6080daec6c55d35fba211 207 SUPERFAMILY SSF53098 16 206 3.79E-62 T 13-10-2018 IPR012337 Ribonuclease H-like superfamily TOPB45_0982 697f92ccd9f6080daec6c55d35fba211 207 Pfam PF01351 Ribonuclease HII 27 203 3.1E-37 T 13-10-2018 IPR024567 Ribonuclease HII/HIII domain TOPB45_0695 fe2e101315b0d7dabb901581de673b4e 223 PIRSF PIRSF001461 5 223 9.3E-97 T 13-10-2018 IPR026019 Ribulose-phosphate 3-epimerase GO:0004750|GO:0006098 KEGG: 00030+5.1.3.1|KEGG: 00040+5.1.3.1|KEGG: 00710+5.1.3.1|MetaCyc: PWY-1861|MetaCyc: PWY-5723|Reactome: R-HSA-71336 TOPB45_0695 fe2e101315b0d7dabb901581de673b4e 223 ProSitePatterns PS01086 Ribulose-phosphate 3-epimerase family signature 2. 140 162 - T 13-10-2018 IPR000056 Ribulose-phosphate 3-epimerase-like GO:0005975|GO:0016857 KEGG: 00030+5.1.3.1|KEGG: 00040+5.1.3.1|KEGG: 00710+5.1.3.1|MetaCyc: PWY-1861|MetaCyc: PWY-5723|Reactome: R-HSA-71336 TOPB45_0695 fe2e101315b0d7dabb901581de673b4e 223 ProSitePatterns PS01085 Ribulose-phosphate 3-epimerase family signature 1. 38 52 - T 13-10-2018 IPR000056 Ribulose-phosphate 3-epimerase-like GO:0005975|GO:0016857 KEGG: 00030+5.1.3.1|KEGG: 00040+5.1.3.1|KEGG: 00710+5.1.3.1|MetaCyc: PWY-1861|MetaCyc: PWY-5723|Reactome: R-HSA-71336 TOPB45_0695 fe2e101315b0d7dabb901581de673b4e 223 SUPERFAMILY SSF51366 8 221 7.07E-79 T 13-10-2018 IPR011060 Ribulose-phosphate binding barrel GO:0003824 TOPB45_0695 fe2e101315b0d7dabb901581de673b4e 223 TIGRFAM TIGR01163 rpe: ribulose-phosphate 3-epimerase 10 220 1.2E-91 T 13-10-2018 IPR000056 Ribulose-phosphate 3-epimerase-like GO:0005975|GO:0016857 KEGG: 00030+5.1.3.1|KEGG: 00040+5.1.3.1|KEGG: 00710+5.1.3.1|MetaCyc: PWY-1861|MetaCyc: PWY-5723|Reactome: R-HSA-71336 TOPB45_0695 fe2e101315b0d7dabb901581de673b4e 223 Pfam PF00834 Ribulose-phosphate 3 epimerase family 11 207 2.3E-85 T 13-10-2018 IPR000056 Ribulose-phosphate 3-epimerase-like GO:0005975|GO:0016857 KEGG: 00030+5.1.3.1|KEGG: 00040+5.1.3.1|KEGG: 00710+5.1.3.1|MetaCyc: PWY-1861|MetaCyc: PWY-5723|Reactome: R-HSA-71336 TOPB45_0695 fe2e101315b0d7dabb901581de673b4e 223 Gene3D G3DSA:3.20.20.70 3 223 3.9E-91 T 13-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 TOPB45_1057 80c717eec80d4d5bf2ba91b1f46f9a2f 160 SUPERFAMILY SSF81301 31 151 4.25E-6 T 13-10-2018 TOPB45_0847 e143a6033680dc0ea0b7a64bf66c2702 129 Gene3D G3DSA:3.30.700.10 6 129 3.8E-23 T 13-10-2018 TOPB45_0847 e143a6033680dc0ea0b7a64bf66c2702 129 TIGRFAM TIGR02532 IV_pilin_GFxxxE: prepilin-type N-terminal cleavage/methylation domain 3 26 1.9E-10 T 13-10-2018 IPR012902 Prokaryotic N-terminal methylation site TOPB45_0847 e143a6033680dc0ea0b7a64bf66c2702 129 Pfam PF07963 Prokaryotic N-terminal methylation motif 2 26 3.3E-10 T 13-10-2018 IPR012902 Prokaryotic N-terminal methylation site TOPB45_0847 e143a6033680dc0ea0b7a64bf66c2702 129 ProSitePatterns PS00409 Prokaryotic N-terminal methylation site. 4 24 - T 13-10-2018 IPR012902 Prokaryotic N-terminal methylation site TOPB45_0847 e143a6033680dc0ea0b7a64bf66c2702 129 SUPERFAMILY SSF54523 6 125 1.05E-20 T 13-10-2018 TOPB45_1188 ec3239e3df03f068695842c70da22a17 319 SMART SM00729 11 215 5.1E-16 T 13-10-2018 IPR006638 Elp3/MiaB/NifB GO:0003824|GO:0051536 TOPB45_1188 ec3239e3df03f068695842c70da22a17 319 Pfam PF04055 Radical SAM superfamily 15 176 4.2E-34 T 13-10-2018 IPR007197 Radical SAM GO:0003824|GO:0051536 TOPB45_1188 ec3239e3df03f068695842c70da22a17 319 Hamap MF_01225_B GTP 3',8-cyclase [moaA]. 2 319 39.75 T 13-10-2018 IPR013483 Molybdenum cofactor biosynthesis protein A GO:0006777|GO:0046872 KEGG: 00790+4.1.99.22|MetaCyc: PWY-6823|Reactome: R-HSA-947581 TOPB45_1188 ec3239e3df03f068695842c70da22a17 319 Pfam PF06463 Molybdenum Cofactor Synthesis C 182 306 2.0E-37 T 13-10-2018 IPR010505 Molybdenum cofactor synthesis C-terminal GO:0006777|GO:0019008|GO:0051539 KEGG: 00790+4.1.99.22|MetaCyc: PWY-6823|Reactome: R-HSA-947581 TOPB45_1188 ec3239e3df03f068695842c70da22a17 319 TIGRFAM TIGR02666 moaA: molybdenum cofactor biosynthesis protein A 2 318 2.3E-114 T 13-10-2018 IPR013483 Molybdenum cofactor biosynthesis protein A GO:0006777|GO:0046872 KEGG: 00790+4.1.99.22|MetaCyc: PWY-6823|Reactome: R-HSA-947581 TOPB45_1188 ec3239e3df03f068695842c70da22a17 319 SUPERFAMILY SSF102114 2 274 8.37E-78 T 13-10-2018 TOPB45_1188 ec3239e3df03f068695842c70da22a17 319 Pfam PF13353 4Fe-4S single cluster domain 18 122 4.4E-11 T 13-10-2018 TOPB45_1188 ec3239e3df03f068695842c70da22a17 319 Gene3D G3DSA:3.20.20.70 1 319 6.6E-102 T 13-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 TOPB45_1476 1f05a5aefd52b04d18b466fd11835114 358 Gene3D G3DSA:1.20.59.10 2 90 2.1E-24 T 13-10-2018 IPR036979 Chorismate mutase domain superfamily GO:0046417 KEGG: 00400+5.4.99.5|MetaCyc: PWY-3461|MetaCyc: PWY-3462|MetaCyc: PWY-6120|MetaCyc: PWY-6627|MetaCyc: PWY-7626 TOPB45_1476 1f05a5aefd52b04d18b466fd11835114 358 SUPERFAMILY SSF53850 90 274 1.41E-60 T 13-10-2018 TOPB45_1476 1f05a5aefd52b04d18b466fd11835114 358 Gene3D G3DSA:3.30.70.260 267 358 1.4E-34 T 13-10-2018 TOPB45_1476 1f05a5aefd52b04d18b466fd11835114 358 Gene3D G3DSA:3.40.190.10 93 263 3.6E-59 T 13-10-2018 TOPB45_1476 1f05a5aefd52b04d18b466fd11835114 358 Pfam PF01842 ACT domain 276 339 1.4E-11 T 13-10-2018 IPR002912 ACT domain TOPB45_1476 1f05a5aefd52b04d18b466fd11835114 358 SMART SM00830 10 89 1.6E-21 T 13-10-2018 IPR002701 Chorismate mutase II, prokaryotic-type GO:0046417 KEGG: 00400+5.4.99.5|MetaCyc: PWY-3461|MetaCyc: PWY-3462|MetaCyc: PWY-6120|MetaCyc: PWY-6627|MetaCyc: PWY-7626 TOPB45_1476 1f05a5aefd52b04d18b466fd11835114 358 Pfam PF00800 Prephenate dehydratase 91 266 2.3E-62 T 13-10-2018 IPR001086 Prephenate dehydratase GO:0004664|GO:0009094 KEGG: 00400+4.2.1.51|MetaCyc: PWY-7432 TOPB45_1476 1f05a5aefd52b04d18b466fd11835114 358 SUPERFAMILY SSF48600 5 93 1.53E-19 T 13-10-2018 IPR036263 Chorismate mutase type II superfamily GO:0046417 KEGG: 00400+5.4.99.5|MetaCyc: PWY-3461|MetaCyc: PWY-3462|MetaCyc: PWY-6120|MetaCyc: PWY-6627|MetaCyc: PWY-7626 TOPB45_1476 1f05a5aefd52b04d18b466fd11835114 358 PIRSF PIRSF001500 1 358 1.4E-127 T 13-10-2018 IPR008242 Bifunctional P-protein, chorismate mutase/prephenate dehydratase GO:0004106|GO:0004664|GO:0005737|GO:0009094 KEGG: 00400+4.2.1.51|MetaCyc: PWY-7432 TOPB45_1476 1f05a5aefd52b04d18b466fd11835114 358 SUPERFAMILY SSF55021 260 355 7.75E-32 T 13-10-2018 TOPB45_1476 1f05a5aefd52b04d18b466fd11835114 358 Gene3D G3DSA:3.40.190.10 171 254 3.6E-59 T 13-10-2018 TOPB45_1476 1f05a5aefd52b04d18b466fd11835114 358 ProSitePatterns PS00857 Prephenate dehydratase signature 1. 241 263 - T 13-10-2018 IPR018528 Prephenate dehydratase, conserved site GO:0004664|GO:0009094 KEGG: 00400+4.2.1.51|MetaCyc: PWY-7432 TOPB45_1476 1f05a5aefd52b04d18b466fd11835114 358 ProSitePatterns PS00858 Prephenate dehydratase signature 2. 303 310 - T 13-10-2018 IPR018528 Prephenate dehydratase, conserved site GO:0004664|GO:0009094 KEGG: 00400+4.2.1.51|MetaCyc: PWY-7432 TOPB45_1476 1f05a5aefd52b04d18b466fd11835114 358 Pfam PF01817 Chorismate mutase type II 10 87 5.5E-19 T 13-10-2018 IPR002701 Chorismate mutase II, prokaryotic-type GO:0046417 KEGG: 00400+5.4.99.5|MetaCyc: PWY-3461|MetaCyc: PWY-3462|MetaCyc: PWY-6120|MetaCyc: PWY-6627|MetaCyc: PWY-7626 TOPB45_0896 6709a7329fc74bd57b0e120fcd269b92 158 Pfam PF13247 4Fe-4S dicluster domain 54 144 3.6E-27 T 13-10-2018 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain TOPB45_0896 6709a7329fc74bd57b0e120fcd269b92 158 SUPERFAMILY SSF54862 3 145 4.92E-49 T 13-10-2018 TOPB45_0896 6709a7329fc74bd57b0e120fcd269b92 158 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 92 103 - T 13-10-2018 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site TOPB45_0896 6709a7329fc74bd57b0e120fcd269b92 158 Gene3D G3DSA:3.30.70.20 34 157 5.3E-42 T 13-10-2018 TOPB45_0451 b7a4314db1241974e26c8f134201dfbe 362 Pfam PF01761 3-dehydroquinate synthase 67 327 1.1E-97 T 13-10-2018 IPR030960 3-dehydroquinate synthase domain KEGG: 00400+4.2.3.4|MetaCyc: PWY-6164 TOPB45_0451 b7a4314db1241974e26c8f134201dfbe 362 SUPERFAMILY SSF56796 6 353 5.63E-105 T 13-10-2018 TOPB45_0451 b7a4314db1241974e26c8f134201dfbe 362 PIRSF PIRSF001455 3 360 1.0E-117 T 13-10-2018 IPR030963 3-dehydroquinate synthase family GO:0009073|GO:0016838 KEGG: 00400+4.2.3.4|MetaCyc: PWY-6164 TOPB45_0451 b7a4314db1241974e26c8f134201dfbe 362 Gene3D G3DSA:3.40.50.1970 1 172 1.5E-63 T 13-10-2018 TOPB45_0451 b7a4314db1241974e26c8f134201dfbe 362 Hamap MF_00110 3-dehydroquinate synthase [aroB]. 1 362 66.8 T 13-10-2018 IPR016037 3-dehydroquinate synthase AroB GO:0003856|GO:0005737|GO:0009073 KEGG: 00400+4.2.3.4|MetaCyc: PWY-6164 TOPB45_0451 b7a4314db1241974e26c8f134201dfbe 362 Gene3D G3DSA:1.20.1090.10 173 360 3.6E-55 T 13-10-2018 TOPB45_0451 b7a4314db1241974e26c8f134201dfbe 362 TIGRFAM TIGR01357 aroB: 3-dehydroquinate synthase 12 349 1.0E-117 T 13-10-2018 IPR016037 3-dehydroquinate synthase AroB GO:0003856|GO:0005737|GO:0009073 KEGG: 00400+4.2.3.4|MetaCyc: PWY-6164 TOPB45_1129 0ce0699a8fde440de0cd99961072d98c 129 PRINTS PR00609 Class III cytochrome C signature 44 53 1.2E-7 T 13-10-2018 IPR002322 Cytochrome c, class III GO:0009055|GO:0020037 TOPB45_1129 0ce0699a8fde440de0cd99961072d98c 129 PRINTS PR00609 Class III cytochrome C signature 120 127 1.2E-7 T 13-10-2018 IPR002322 Cytochrome c, class III GO:0009055|GO:0020037 TOPB45_1129 0ce0699a8fde440de0cd99961072d98c 129 PRINTS PR00609 Class III cytochrome C signature 58 65 1.2E-7 T 13-10-2018 IPR002322 Cytochrome c, class III GO:0009055|GO:0020037 TOPB45_1129 0ce0699a8fde440de0cd99961072d98c 129 PRINTS PR00609 Class III cytochrome C signature 102 113 1.2E-7 T 13-10-2018 IPR002322 Cytochrome c, class III GO:0009055|GO:0020037 TOPB45_1129 0ce0699a8fde440de0cd99961072d98c 129 Pfam PF02085 Class III cytochrome C family 36 127 3.5E-15 T 13-10-2018 IPR020942 Class III cytochrome C GO:0009055|GO:0020037 TOPB45_1129 0ce0699a8fde440de0cd99961072d98c 129 Gene3D G3DSA:3.90.10.10 19 129 2.7E-20 T 13-10-2018 TOPB45_1129 0ce0699a8fde440de0cd99961072d98c 129 SUPERFAMILY SSF48695 26 129 1.96E-15 T 13-10-2018 IPR036280 Multiheme cytochrome superfamily TOPB45_1123 34a27d0a77b6f70a4991750900bf7b0e 239 SMART SM00363 1 59 1.3E-11 T 13-10-2018 IPR002942 RNA-binding S4 domain GO:0003723 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_1123 34a27d0a77b6f70a4991750900bf7b0e 239 Gene3D G3DSA:3.10.290.10 1 56 3.4E-18 T 13-10-2018 IPR036986 RNA-binding S4 domain superfamily GO:0003723 TOPB45_1123 34a27d0a77b6f70a4991750900bf7b0e 239 Pfam PF01479 S4 domain 1 43 1.0E-12 T 13-10-2018 IPR002942 RNA-binding S4 domain GO:0003723 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_1123 34a27d0a77b6f70a4991750900bf7b0e 239 Pfam PF00849 RNA pseudouridylate synthase 63 192 3.5E-14 T 13-10-2018 IPR006145 Pseudouridine synthase, RsuA/RluB/C/D/E/F GO:0001522|GO:0003723|GO:0009451|GO:0009982 TOPB45_1123 34a27d0a77b6f70a4991750900bf7b0e 239 TIGRFAM TIGR00093 TIGR00093: pseudouridine synthase 67 223 9.3E-44 T 13-10-2018 IPR000748 Pseudouridine synthase, RsuA/RluB/E/F GO:0001522|GO:0003723|GO:0009451|GO:0016866 TOPB45_1123 34a27d0a77b6f70a4991750900bf7b0e 239 ProSitePatterns PS01149 Rsu family of pseudouridine synthase signature. 101 115 - T 13-10-2018 IPR018496 Pseudouridine synthase, RsuA/RluB/E/F, conserved site GO:0001522|GO:0003723|GO:0009451|GO:0016866 TOPB45_1123 34a27d0a77b6f70a4991750900bf7b0e 239 Gene3D G3DSA:3.30.70.580 63 228 3.0E-52 T 13-10-2018 TOPB45_1123 34a27d0a77b6f70a4991750900bf7b0e 239 SUPERFAMILY SSF55174 1 87 5.15E-17 T 13-10-2018 TOPB45_1123 34a27d0a77b6f70a4991750900bf7b0e 239 Gene3D G3DSA:3.30.70.1560 130 211 3.0E-52 T 13-10-2018 TOPB45_1123 34a27d0a77b6f70a4991750900bf7b0e 239 SUPERFAMILY SSF55120 61 229 3.36E-36 T 13-10-2018 IPR020103 Pseudouridine synthase, catalytic domain superfamily GO:0001522|GO:0003723|GO:0009451|GO:0009982 TOPB45_0996 24055b7dba0e268049c1c56404f6998e 346 SUPERFAMILY SSF102405 65 270 3.82E-42 T 13-10-2018 TOPB45_0996 24055b7dba0e268049c1c56404f6998e 346 Gene3D G3DSA:1.10.10.10 276 342 1.7E-6 T 13-10-2018 IPR036388 Winged helix-like DNA-binding domain superfamily TOPB45_0996 24055b7dba0e268049c1c56404f6998e 346 Pfam PF02481 DNA recombination-mediator protein A 55 261 2.1E-81 T 13-10-2018 IPR003488 DNA recombination-mediator protein A GO:0009294 TOPB45_0996 24055b7dba0e268049c1c56404f6998e 346 Gene3D G3DSA:3.40.50.450 10 275 3.6E-98 T 13-10-2018 TOPB45_0996 24055b7dba0e268049c1c56404f6998e 346 TIGRFAM TIGR00732 dprA: DNA protecting protein DprA 54 268 3.3E-81 T 13-10-2018 IPR003488 DNA recombination-mediator protein A GO:0009294 TOPB45_1274 a002fd059cbd4ccf599fa2c4603f788b 220 Gene3D G3DSA:2.40.50.100 16 102 7.2E-13 T 13-10-2018 TOPB45_1274 a002fd059cbd4ccf599fa2c4603f788b 220 SUPERFAMILY SSF51230 18 99 8.7E-6 T 13-10-2018 IPR011053 Single hybrid motif TOPB45_1540 fa15d9d61803b1121b367f8418d4af73 437 SUPERFAMILY SSF52540 4 80 1.64E-5 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1540 fa15d9d61803b1121b367f8418d4af73 437 Gene3D G3DSA:3.40.50.300 4 168 2.3E-46 T 13-10-2018 TOPB45_1540 fa15d9d61803b1121b367f8418d4af73 437 Pfam PF14714 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal 354 434 4.5E-22 T 13-10-2018 IPR032859 GTPase Der, C-terminal KH-domain-like TOPB45_1540 fa15d9d61803b1121b367f8418d4af73 437 SUPERFAMILY SSF82653 355 422 1.18E-8 T 13-10-2018 TOPB45_1540 fa15d9d61803b1121b367f8418d4af73 437 Gene3D G3DSA:3.30.300.20 350 436 5.2E-22 T 13-10-2018 IPR015946 K homology domain-like, alpha/beta TOPB45_1540 fa15d9d61803b1121b367f8418d4af73 437 Pfam PF01926 50S ribosome-binding GTPase 177 296 2.2E-25 T 13-10-2018 IPR006073 GTP binding domain GO:0005525 TOPB45_1540 fa15d9d61803b1121b367f8418d4af73 437 Pfam PF01926 50S ribosome-binding GTPase 3 120 1.4E-26 T 13-10-2018 IPR006073 GTP binding domain GO:0005525 TOPB45_1540 fa15d9d61803b1121b367f8418d4af73 437 PRINTS PR00449 Transforming protein P21 ras signature 326 348 2.3E-5 T 13-10-2018 TOPB45_1540 fa15d9d61803b1121b367f8418d4af73 437 PRINTS PR00449 Transforming protein P21 ras signature 286 299 2.3E-5 T 13-10-2018 TOPB45_1540 fa15d9d61803b1121b367f8418d4af73 437 PRINTS PR00449 Transforming protein P21 ras signature 176 197 2.3E-5 T 13-10-2018 TOPB45_1540 fa15d9d61803b1121b367f8418d4af73 437 Gene3D G3DSA:3.40.50.300 173 349 2.9E-49 T 13-10-2018 TOPB45_1540 fa15d9d61803b1121b367f8418d4af73 437 Hamap MF_00195 GTPase Der [der]. 1 437 35.18 T 13-10-2018 IPR016484 GTP-binding protein EngA GO:0005525 TOPB45_1540 fa15d9d61803b1121b367f8418d4af73 437 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 176 345 2.2E-27 T 13-10-2018 IPR005225 Small GTP-binding protein domain GO:0005525 TOPB45_1540 fa15d9d61803b1121b367f8418d4af73 437 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 2 160 1.5E-29 T 13-10-2018 IPR005225 Small GTP-binding protein domain GO:0005525 TOPB45_1540 fa15d9d61803b1121b367f8418d4af73 437 SUPERFAMILY SSF52540 70 345 1.04E-56 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1540 fa15d9d61803b1121b367f8418d4af73 437 TIGRFAM TIGR03594 GTPase_EngA: ribosome-associated GTPase EngA 3 434 5.0E-150 T 13-10-2018 IPR016484 GTP-binding protein EngA GO:0005525 TOPB45_1540 fa15d9d61803b1121b367f8418d4af73 437 PIRSF PIRSF006485 1 437 1.0E-148 T 13-10-2018 IPR016484 GTP-binding protein EngA GO:0005525 TOPB45_0667 00959f5ce9deae735a000c24474819f4 195 SUPERFAMILY SSF48317 53 190 2.09E-23 T 13-10-2018 IPR036938 Phosphatidic acid phosphatase type 2/haloperoxidase superfamily TOPB45_0667 00959f5ce9deae735a000c24474819f4 195 Gene3D G3DSA:1.20.144.10 118 193 3.3E-12 T 13-10-2018 TOPB45_0667 00959f5ce9deae735a000c24474819f4 195 SMART SM00014 79 189 7.5E-9 T 13-10-2018 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase TOPB45_0667 00959f5ce9deae735a000c24474819f4 195 Pfam PF01569 PAP2 superfamily 82 189 8.2E-17 T 13-10-2018 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase TOPB45_0778 92f8fc7943d739febce564e4fd72acaa 123 Pfam PF00416 Ribosomal protein S13/S18 4 109 5.3E-35 T 13-10-2018 IPR001892 Ribosomal protein S13 GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0778 92f8fc7943d739febce564e4fd72acaa 123 PIRSF PIRSF002134 1 123 4.9E-45 T 13-10-2018 IPR001892 Ribosomal protein S13 GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0778 92f8fc7943d739febce564e4fd72acaa 123 Gene3D G3DSA:4.10.910.10 73 123 1.5E-23 T 13-10-2018 IPR027437 30s ribosomal protein S13, C-terminal Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0778 92f8fc7943d739febce564e4fd72acaa 123 Hamap MF_01315 30S ribosomal protein S13 [rpsM]. 1 119 27.633 T 13-10-2018 IPR001892 Ribosomal protein S13 GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0778 92f8fc7943d739febce564e4fd72acaa 123 SUPERFAMILY SSF46946 4 121 7.36E-46 T 13-10-2018 IPR010979 Ribosomal protein S13-like, H2TH GO:0003676 TOPB45_0778 92f8fc7943d739febce564e4fd72acaa 123 Gene3D G3DSA:1.10.8.50 1 72 1.3E-30 T 13-10-2018 TOPB45_0778 92f8fc7943d739febce564e4fd72acaa 123 TIGRFAM TIGR03631 uS13_bact: ribosomal protein uS13 3 114 2.7E-52 T 13-10-2018 IPR019980 Ribosomal protein S13, bacterial-type GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0778 92f8fc7943d739febce564e4fd72acaa 123 ProSitePatterns PS00646 Ribosomal protein S13 signature. 88 101 - T 13-10-2018 IPR018269 Ribosomal protein S13, conserved site GO:0003723|GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0142 8c211d390e6eb7e492598954f627a0a4 252 SUPERFAMILY SSF56281 26 246 8.12E-30 T 13-10-2018 IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like TOPB45_0142 8c211d390e6eb7e492598954f627a0a4 252 Pfam PF00753 Metallo-beta-lactamase superfamily 36 178 1.0E-12 T 13-10-2018 IPR001279 Metallo-beta-lactamase TOPB45_0142 8c211d390e6eb7e492598954f627a0a4 252 Gene3D G3DSA:3.60.15.10 5 244 2.1E-41 T 13-10-2018 IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like TOPB45_0142 8c211d390e6eb7e492598954f627a0a4 252 SMART SM00849 37 241 6.3E-11 T 13-10-2018 IPR001279 Metallo-beta-lactamase TOPB45_0772 7bdc7bb175e96630bfd4b46f44ea38d4 153 ProSitePatterns PS00475 Ribosomal protein L15 signature. 115 145 - T 13-10-2018 IPR001196 Ribosomal protein L15, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0772 7bdc7bb175e96630bfd4b46f44ea38d4 153 Hamap MF_01341 50S ribosomal protein L15 [rplO]. 7 151 21.414 T 13-10-2018 IPR030878 Ribosomal protein L15 GO:0003735|GO:0006412|GO:0015934 TOPB45_0772 7bdc7bb175e96630bfd4b46f44ea38d4 153 Pfam PF00828 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A 31 149 2.2E-37 T 13-10-2018 IPR021131 Ribosomal protein L18e/L15P TOPB45_0772 7bdc7bb175e96630bfd4b46f44ea38d4 153 TIGRFAM TIGR01071 rplO_bact: ribosomal protein uL15 7 149 3.5E-53 T 13-10-2018 IPR005749 Ribosomal protein L15, bacterial-type GO:0003735|GO:0006412|GO:0015934 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0772 7bdc7bb175e96630bfd4b46f44ea38d4 153 SUPERFAMILY SSF52080 9 149 9.42E-47 T 13-10-2018 IPR036227 Ribosomal L18e/L15P superfamily TOPB45_0772 7bdc7bb175e96630bfd4b46f44ea38d4 153 Gene3D G3DSA:3.100.10.10 71 153 5.2E-22 T 13-10-2018 TOPB45_1556 8a3dbe52af56f81987b0830886f4056c 463 SUPERFAMILY SSF53686 1 460 3.02E-158 T 13-10-2018 IPR036052 Tryptophan synthase beta subunit-like PLP-dependent enzyme TOPB45_1556 8a3dbe52af56f81987b0830886f4056c 463 Pfam PF14821 Threonine synthase N terminus 2 79 3.7E-29 T 13-10-2018 IPR029144 Threonine synthase, N-terminal TOPB45_1556 8a3dbe52af56f81987b0830886f4056c 463 TIGRFAM TIGR00260 thrC: threonine synthase 65 432 1.7E-93 T 13-10-2018 IPR004450 Threonine synthase-like TOPB45_1556 8a3dbe52af56f81987b0830886f4056c 463 Gene3D G3DSA:3.90.1380.10 1 85 2.6E-29 T 13-10-2018 IPR037158 Threonine synthase, N-terminal domain superfamily TOPB45_1556 8a3dbe52af56f81987b0830886f4056c 463 Gene3D G3DSA:3.40.50.1100 106 443 1.9E-148 T 13-10-2018 TOPB45_1556 8a3dbe52af56f81987b0830886f4056c 463 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 92 396 9.8E-16 T 13-10-2018 IPR001926 Pyridoxal-phosphate dependent enzyme TOPB45_1556 8a3dbe52af56f81987b0830886f4056c 463 Gene3D G3DSA:3.40.50.1100 95 430 1.9E-148 T 13-10-2018 TOPB45_1127 9d8f915c0afb27c42d50e77f9f37def4 903 SUPERFAMILY SSF48695 34 229 1.03E-21 T 13-10-2018 IPR036280 Multiheme cytochrome superfamily TOPB45_1127 9d8f915c0afb27c42d50e77f9f37def4 903 ProSitePatterns PS00018 EF-hand calcium-binding domain. 760 772 - T 13-10-2018 IPR018247 EF-Hand 1, calcium-binding site TOPB45_1127 9d8f915c0afb27c42d50e77f9f37def4 903 Gene3D G3DSA:3.90.10.10 516 631 2.4E-6 T 13-10-2018 TOPB45_1127 9d8f915c0afb27c42d50e77f9f37def4 903 Gene3D G3DSA:3.90.10.10 163 279 1.2E-5 T 13-10-2018 TOPB45_1127 9d8f915c0afb27c42d50e77f9f37def4 903 Gene3D G3DSA:3.90.10.10 283 399 4.3E-5 T 13-10-2018 TOPB45_1127 9d8f915c0afb27c42d50e77f9f37def4 903 Gene3D G3DSA:3.90.10.10 400 515 5.5E-6 T 13-10-2018 TOPB45_1127 9d8f915c0afb27c42d50e77f9f37def4 903 Gene3D G3DSA:3.90.10.10 49 162 7.6E-8 T 13-10-2018 TOPB45_1127 9d8f915c0afb27c42d50e77f9f37def4 903 Pfam PF13435 Cytochrome c554 and c-prime 629 720 7.7E-4 T 13-10-2018 IPR023155 Cytochrome c-552/4 TOPB45_1127 9d8f915c0afb27c42d50e77f9f37def4 903 SUPERFAMILY SSF48695 268 514 1.61E-20 T 13-10-2018 IPR036280 Multiheme cytochrome superfamily TOPB45_1127 9d8f915c0afb27c42d50e77f9f37def4 903 SUPERFAMILY SSF48695 477 821 1.26E-28 T 13-10-2018 IPR036280 Multiheme cytochrome superfamily TOPB45_1127 9d8f915c0afb27c42d50e77f9f37def4 903 Gene3D G3DSA:1.10.1130.10 632 804 3.7E-5 T 13-10-2018 TOPB45_1162 d08211235750185bb7a31688eb2d1a75 278 TIGRFAM TIGR01697 PNPH-PUNA-XAPA: inosine/guanosine/xanthosine phosphorylase family 28 273 6.5E-92 T 13-10-2018 IPR011268 Purine nucleoside phosphorylase GO:0004731|GO:0006139 KEGG: 00230+2.4.2.1|KEGG: 00240+2.4.2.1|KEGG: 00760+2.4.2.1|MetaCyc: PWY-4202|MetaCyc: PWY-5532|MetaCyc: PWY-5695|MetaCyc: PWY-6608|MetaCyc: PWY-6609|MetaCyc: PWY-6611|MetaCyc: PWY-6620|MetaCyc: PWY-6627|MetaCyc: PWY-6644|MetaCyc: PWY-7179|MetaCyc: PWY-7179-1|Reactome: R-HSA-6798695|Reactome: R-HSA-74217|Reactome: R-HSA-74259 TOPB45_1162 d08211235750185bb7a31688eb2d1a75 278 PIRSF PIRSF000477 1 276 8.4E-98 T 13-10-2018 IPR011268 Purine nucleoside phosphorylase GO:0004731|GO:0006139 KEGG: 00230+2.4.2.1|KEGG: 00240+2.4.2.1|KEGG: 00760+2.4.2.1|MetaCyc: PWY-4202|MetaCyc: PWY-5532|MetaCyc: PWY-5695|MetaCyc: PWY-6608|MetaCyc: PWY-6609|MetaCyc: PWY-6611|MetaCyc: PWY-6620|MetaCyc: PWY-6627|MetaCyc: PWY-6644|MetaCyc: PWY-7179|MetaCyc: PWY-7179-1|Reactome: R-HSA-6798695|Reactome: R-HSA-74217|Reactome: R-HSA-74259 TOPB45_1162 d08211235750185bb7a31688eb2d1a75 278 SUPERFAMILY SSF53167 7 276 1.95E-83 T 13-10-2018 IPR035994 Nucleoside phosphorylase superfamily GO:0003824|GO:0009116 TOPB45_1162 d08211235750185bb7a31688eb2d1a75 278 Pfam PF01048 Phosphorylase superfamily 27 274 1.4E-47 T 13-10-2018 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 TOPB45_1162 d08211235750185bb7a31688eb2d1a75 278 Gene3D G3DSA:3.40.50.1580 1 275 1.2E-100 T 13-10-2018 TOPB45_1162 d08211235750185bb7a31688eb2d1a75 278 TIGRFAM TIGR01700 PNPH: purine nucleoside phosphorylase I, inosine and guanosine-specific 27 273 8.4E-96 T 13-10-2018 IPR011270 Purine nucleoside phosphorylase I, inosine/guanosine-specific GO:0004731|GO:0006139 KEGG: 00230+2.4.2.1|KEGG: 00240+2.4.2.1|KEGG: 00760+2.4.2.1|MetaCyc: PWY-4202|MetaCyc: PWY-5532|MetaCyc: PWY-5695|MetaCyc: PWY-6608|MetaCyc: PWY-6609|MetaCyc: PWY-6611|MetaCyc: PWY-6620|MetaCyc: PWY-6627|MetaCyc: PWY-6644|MetaCyc: PWY-7179|MetaCyc: PWY-7179-1|Reactome: R-HSA-6798695|Reactome: R-HSA-74217|Reactome: R-HSA-74259 TOPB45_1166 14f1b75952f81743f9188c2bde1c0983 574 Gene3D G3DSA:3.40.50.300 331 574 1.2E-83 T 13-10-2018 TOPB45_1166 14f1b75952f81743f9188c2bde1c0983 574 SMART SM00382 361 547 1.9E-14 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_1166 14f1b75952f81743f9188c2bde1c0983 574 Pfam PF00005 ABC transporter 352 501 1.5E-30 T 13-10-2018 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TOPB45_1166 14f1b75952f81743f9188c2bde1c0983 574 ProSitePatterns PS00211 ABC transporters family signature. 473 487 - T 13-10-2018 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TOPB45_1166 14f1b75952f81743f9188c2bde1c0983 574 SUPERFAMILY SSF90123 8 320 3.66E-62 T 13-10-2018 IPR036640 ABC transporter type 1, transmembrane domain superfamily GO:0005524|GO:0016021 TOPB45_1166 14f1b75952f81743f9188c2bde1c0983 574 Pfam PF00664 ABC transporter transmembrane region 23 292 1.1E-38 T 13-10-2018 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0016021|GO:0042626|GO:0055085 TOPB45_1166 14f1b75952f81743f9188c2bde1c0983 574 Gene3D G3DSA:1.20.1560.10 5 323 1.0E-67 T 13-10-2018 IPR036640 ABC transporter type 1, transmembrane domain superfamily GO:0005524|GO:0016021 TOPB45_1166 14f1b75952f81743f9188c2bde1c0983 574 SUPERFAMILY SSF52540 328 570 4.77E-88 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1311 f920647fde9c70e1a1e8b19830b4386f 250 Pfam PF02361 Cobalt transport protein 11 215 8.2E-32 T 13-10-2018 IPR003339 ABC/ECF transporter, transmembrane component TOPB45_1311 f920647fde9c70e1a1e8b19830b4386f 250 TIGRFAM TIGR02454 ECF_T_CbiQ: cobalt ECF transporter T component CbiQ 16 211 3.5E-39 T 13-10-2018 IPR012809 Cobalt ECF transporter T component CbiQ GO:0005887|GO:0006824|GO:0043190 TOPB45_0238 59c8f12e5684bda825806c664fbb92db 301 PRINTS PR01386 Cytochrome c-type biogenesis protein CcmC signature 235 255 1.3E-5 T 13-10-2018 IPR003557 Cytochrome c-type biogenesis protein CcmC GO:0015232|GO:0015886|GO:0016020|GO:0017004 TOPB45_0238 59c8f12e5684bda825806c664fbb92db 301 PRINTS PR01386 Cytochrome c-type biogenesis protein CcmC signature 214 234 1.3E-5 T 13-10-2018 IPR003557 Cytochrome c-type biogenesis protein CcmC GO:0015232|GO:0015886|GO:0016020|GO:0017004 TOPB45_0238 59c8f12e5684bda825806c664fbb92db 301 TIGRFAM TIGR03144 cytochr_II_ccsB: cytochrome c-type biogenesis protein CcsB 69 299 2.2E-76 T 13-10-2018 IPR017562 Cytochrome c-type biogenesis protein CcsA GO:0017004 TOPB45_0238 59c8f12e5684bda825806c664fbb92db 301 Pfam PF01578 Cytochrome C assembly protein 96 296 2.1E-55 T 13-10-2018 IPR002541 Cytochrome c assembly protein GO:0017004|GO:0020037 TOPB45_0472 4a1dd6459d66a0866944173ab28fa47a 152 Gene3D G3DSA:3.40.140.10 1 152 9.1E-60 T 13-10-2018 TOPB45_0472 4a1dd6459d66a0866944173ab28fa47a 152 ProSitePatterns PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 56 93 - T 13-10-2018 IPR016192 APOBEC/CMP deaminase, zinc-binding GO:0008270|GO:0016787 TOPB45_0472 4a1dd6459d66a0866944173ab28fa47a 152 SUPERFAMILY SSF53927 4 152 1.17E-52 T 13-10-2018 IPR016193 Cytidine deaminase-like GO:0003824 TOPB45_0472 4a1dd6459d66a0866944173ab28fa47a 152 Hamap MF_00972 tRNA-specific adenosine deaminase [tadA]. 10 152 45.698 T 13-10-2018 IPR028883 tRNA-specific adenosine deaminase GO:0002100|GO:0008251 Reactome: R-HSA-6782315 TOPB45_0472 4a1dd6459d66a0866944173ab28fa47a 152 Pfam PF14437 MafB19-like deaminase 6 151 3.2E-31 T 13-10-2018 IPR028883 tRNA-specific adenosine deaminase GO:0002100|GO:0008251 Reactome: R-HSA-6782315 TOPB45_0272 7240428891a134831c83e4b3780de32e 227 SUPERFAMILY SSF53335 10 218 3.22E-35 T 13-10-2018 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TOPB45_0272 7240428891a134831c83e4b3780de32e 227 Pfam PF01209 ubiE/COQ5 methyltransferase family 5 226 2.5E-58 T 13-10-2018 IPR004033 UbiE/COQ5 methyltransferase GO:0008168 KEGG: 00130+2.1.1.163|MetaCyc: PWY-5839|MetaCyc: PWY-5844|MetaCyc: PWY-5849|MetaCyc: PWY-5890|MetaCyc: PWY-5891|MetaCyc: PWY-5892|MetaCyc: PWY-5895|Reactome: R-HSA-2142789 TOPB45_0272 7240428891a134831c83e4b3780de32e 227 Hamap MF_01813 Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE [ubiE]. 1 226 31.977 T 13-10-2018 IPR004033 UbiE/COQ5 methyltransferase GO:0008168 KEGG: 00130+2.1.1.163|MetaCyc: PWY-5839|MetaCyc: PWY-5844|MetaCyc: PWY-5849|MetaCyc: PWY-5890|MetaCyc: PWY-5891|MetaCyc: PWY-5892|MetaCyc: PWY-5895|Reactome: R-HSA-2142789 TOPB45_0272 7240428891a134831c83e4b3780de32e 227 ProSitePatterns PS01184 ubiE/COQ5 methyltransferase family signature 2. 134 148 - T 13-10-2018 IPR023576 UbiE/COQ5 methyltransferase, conserved site GO:0008168 KEGG: 00130+2.1.1.163|MetaCyc: PWY-5839|MetaCyc: PWY-5844|MetaCyc: PWY-5849|MetaCyc: PWY-5890|MetaCyc: PWY-5891|MetaCyc: PWY-5892|MetaCyc: PWY-5895 TOPB45_0272 7240428891a134831c83e4b3780de32e 227 Gene3D G3DSA:3.40.50.150 14 227 1.2E-55 T 13-10-2018 TOPB45_0272 7240428891a134831c83e4b3780de32e 227 TIGRFAM TIGR01934 MenG_MenH_UbiE: ubiquinone/menaquinone biosynthesis methyltransferase 8 226 6.1E-66 T 13-10-2018 IPR004033 UbiE/COQ5 methyltransferase GO:0008168 KEGG: 00130+2.1.1.163|MetaCyc: PWY-5839|MetaCyc: PWY-5844|MetaCyc: PWY-5849|MetaCyc: PWY-5890|MetaCyc: PWY-5891|MetaCyc: PWY-5892|MetaCyc: PWY-5895|Reactome: R-HSA-2142789 TOPB45_0607 2b4135f98fa53f156bfde6b9b45708f9 169 PIRSF PIRSF006162 11 167 1.5E-35 T 13-10-2018 IPR026037 Phosphatidylglycerophosphatase A KEGG: 00564+3.1.3.27|MetaCyc: PWY-5269|MetaCyc: PWY-5668|MetaCyc: PWY-7817 TOPB45_0607 2b4135f98fa53f156bfde6b9b45708f9 169 Pfam PF04608 Phosphatidylglycerophosphatase A 23 158 7.7E-34 T 13-10-2018 IPR007686 YutG/PgpA domain GO:0006629|GO:0008962 TOPB45_0607 2b4135f98fa53f156bfde6b9b45708f9 169 SUPERFAMILY SSF101307 18 159 1.83E-26 T 13-10-2018 IPR036681 PgpA-like superfamily GO:0006629|GO:0008962 TOPB45_0187 45ac30fe81adbf954385a1ca6946bba5 461 Gene3D G3DSA:3.40.50.300 182 459 3.3E-107 T 13-10-2018 TOPB45_0187 45ac30fe81adbf954385a1ca6946bba5 461 SUPERFAMILY SSF52540 198 446 1.03E-52 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0187 45ac30fe81adbf954385a1ca6946bba5 461 Gene3D G3DSA:1.10.860.10 19 181 6.3E-50 T 13-10-2018 IPR016136 DNA helicase DnaB, N-terminal/DNA primase DnaG, C-terminal TOPB45_0187 45ac30fe81adbf954385a1ca6946bba5 461 SMART SM00382 217 414 2.0E-4 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_0187 45ac30fe81adbf954385a1ca6946bba5 461 SUPERFAMILY SSF48024 25 134 2.62E-35 T 13-10-2018 IPR036185 DNA helicase, DnaB-like, N-terminal domain superfamily GO:0003678|GO:0005524|GO:0006260 TOPB45_0187 45ac30fe81adbf954385a1ca6946bba5 461 Pfam PF03796 DnaB-like helicase C terminal domain 200 454 4.7E-111 T 13-10-2018 IPR007694 DNA helicase, DnaB-like, C-terminal GO:0003678|GO:0005524|GO:0006260 Reactome: R-HSA-2151201 TOPB45_0187 45ac30fe81adbf954385a1ca6946bba5 461 Pfam PF00772 DnaB-like helicase N terminal domain 25 126 2.7E-32 T 13-10-2018 IPR007693 DNA helicase, DnaB-like, N-terminal GO:0003678|GO:0005524|GO:0006260 TOPB45_0187 45ac30fe81adbf954385a1ca6946bba5 461 TIGRFAM TIGR00665 DnaB: replicative DNA helicase 24 456 1.9E-170 T 13-10-2018 IPR007692 DNA helicase, DnaB type GO:0003677|GO:0003678|GO:0005524|GO:0006260 TOPB45_1177 305361039a13a9e6d747ba26deb0de8d 130 SUPERFAMILY SSF53146 1 108 1.44E-24 T 13-10-2018 IPR036105 Dinitrogenase iron-molybdenum cofactor biosynthesis superfamily TOPB45_1177 305361039a13a9e6d747ba26deb0de8d 130 Gene3D G3DSA:3.30.420.130 1 111 2.3E-24 T 13-10-2018 IPR036105 Dinitrogenase iron-molybdenum cofactor biosynthesis superfamily TOPB45_1177 305361039a13a9e6d747ba26deb0de8d 130 Pfam PF02579 Dinitrogenase iron-molybdenum cofactor 19 102 5.4E-17 T 13-10-2018 IPR003731 Dinitrogenase iron-molybdenum cofactor biosynthesis TOPB45_1543 bc76f30e43da5830ddcb55226802cf4c 231 TIGRFAM TIGR00044 TIGR00044: pyridoxal phosphate enzyme, YggS family 14 230 1.1E-56 T 13-10-2018 IPR011078 Pyridoxal phosphate homeostasis protein GO:0030170 TOPB45_1543 bc76f30e43da5830ddcb55226802cf4c 231 Pfam PF01168 Alanine racemase, N-terminal domain 17 230 2.9E-17 T 13-10-2018 IPR001608 Alanine racemase, N-terminal KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 TOPB45_1543 bc76f30e43da5830ddcb55226802cf4c 231 Gene3D G3DSA:3.20.20.10 2 231 2.3E-77 T 13-10-2018 IPR029066 PLP-binding barrel TOPB45_1543 bc76f30e43da5830ddcb55226802cf4c 231 SUPERFAMILY SSF51419 7 228 7.85E-72 T 13-10-2018 IPR029066 PLP-binding barrel TOPB45_1543 bc76f30e43da5830ddcb55226802cf4c 231 PIRSF PIRSF004848 3 231 1.0E-74 T 13-10-2018 IPR011078 Pyridoxal phosphate homeostasis protein GO:0030170 TOPB45_1543 bc76f30e43da5830ddcb55226802cf4c 231 Hamap MF_02087 Pyridoxal phosphate homeostasis protein. 9 229 30.024 T 13-10-2018 IPR011078 Pyridoxal phosphate homeostasis protein GO:0030170 TOPB45_1212 4051d1eef3f61d036fbc37270141fc51 653 Gene3D G3DSA:3.55.50.30 166 273 1.8E-28 T 13-10-2018 TOPB45_1212 4051d1eef3f61d036fbc37270141fc51 653 Gene3D G3DSA:3.30.1370.120 274 379 3.3E-16 T 13-10-2018 IPR038591 NolW-like superfamily TOPB45_1212 4051d1eef3f61d036fbc37270141fc51 653 Pfam PF00263 Bacterial type II and III secretion system protein 486 643 3.7E-41 T 13-10-2018 IPR004846 Type II/III secretion system GO:0009306 TOPB45_1212 4051d1eef3f61d036fbc37270141fc51 653 PRINTS PR00811 Bacterial general secretion pathway protein D signature 609 627 2.8E-13 T 13-10-2018 IPR001775 GspD/PilQ family TOPB45_1212 4051d1eef3f61d036fbc37270141fc51 653 PRINTS PR00811 Bacterial general secretion pathway protein D signature 482 506 2.8E-13 T 13-10-2018 IPR001775 GspD/PilQ family TOPB45_1212 4051d1eef3f61d036fbc37270141fc51 653 PRINTS PR00811 Bacterial general secretion pathway protein D signature 632 646 2.8E-13 T 13-10-2018 IPR001775 GspD/PilQ family TOPB45_1212 4051d1eef3f61d036fbc37270141fc51 653 PRINTS PR00811 Bacterial general secretion pathway protein D signature 378 388 2.8E-13 T 13-10-2018 IPR001775 GspD/PilQ family TOPB45_1212 4051d1eef3f61d036fbc37270141fc51 653 TIGRFAM TIGR02515 IV_pilus_PilQ: type IV pilus secretin PilQ 187 643 1.0E-95 T 13-10-2018 IPR013355 Type IV pilus secretin PilQ TOPB45_1212 4051d1eef3f61d036fbc37270141fc51 653 Pfam PF03958 Bacterial type II/III secretion system short domain 308 378 1.2E-9 T 13-10-2018 IPR005644 NolW-like TOPB45_0106 e85c1c6e0fd1bc82b0aa7c499f27b91f 158 SUPERFAMILY SSF52121 5 155 1.7E-64 T 13-10-2018 IPR036467 Lumazine/riboflavin synthase superfamily GO:0009231|GO:0009349 KEGG: 00740+2.5.1.78|MetaCyc: PWY-6167|MetaCyc: PWY-6168 TOPB45_0106 e85c1c6e0fd1bc82b0aa7c499f27b91f 158 Pfam PF00885 6,7-dimethyl-8-ribityllumazine synthase 15 152 5.4E-61 T 13-10-2018 IPR002180 Lumazine/riboflavin synthase GO:0009231|GO:0009349 KEGG: 00740+2.5.1.78|MetaCyc: PWY-6167|MetaCyc: PWY-6168 TOPB45_0106 e85c1c6e0fd1bc82b0aa7c499f27b91f 158 Gene3D G3DSA:3.40.50.960 4 156 6.8E-65 T 13-10-2018 IPR036467 Lumazine/riboflavin synthase superfamily GO:0009231|GO:0009349 KEGG: 00740+2.5.1.78|MetaCyc: PWY-6167|MetaCyc: PWY-6168 TOPB45_0106 e85c1c6e0fd1bc82b0aa7c499f27b91f 158 TIGRFAM TIGR00114 lumazine-synth: 6,7-dimethyl-8-ribityllumazine synthase 15 151 2.9E-59 T 13-10-2018 IPR034964 Lumazine synthase GO:0000906|GO:0009231 KEGG: 00740+2.5.1.78|MetaCyc: PWY-6167|MetaCyc: PWY-6168 TOPB45_0106 e85c1c6e0fd1bc82b0aa7c499f27b91f 158 Hamap MF_00178 6,7-dimethyl-8-ribityllumazine synthase [ribH]. 10 155 31.835 T 13-10-2018 IPR034964 Lumazine synthase GO:0000906|GO:0009231 KEGG: 00740+2.5.1.78|MetaCyc: PWY-6167|MetaCyc: PWY-6168 TOPB45_1103 fa9208033d3d80ddb54fe2e53592b0cd 134 Gene3D G3DSA:3.40.50.1010 3 132 5.4E-22 T 13-10-2018 TOPB45_1103 fa9208033d3d80ddb54fe2e53592b0cd 134 SUPERFAMILY SSF88723 1 133 6.73E-20 T 13-10-2018 IPR029060 PIN-like domain superfamily TOPB45_1103 fa9208033d3d80ddb54fe2e53592b0cd 134 Pfam PF01850 PIN domain 4 127 2.2E-17 T 13-10-2018 IPR002716 PIN domain TOPB45_0180 f2acfd5db8d60c647fba38cb221c32e7 328 ProSitePatterns PS00444 Polyprenyl synthases signature 2. 209 221 - T 13-10-2018 IPR033749 Polyprenyl synthetase, conserved site TOPB45_0180 f2acfd5db8d60c647fba38cb221c32e7 328 ProSitePatterns PS00723 Polyprenyl synthases signature 1. 87 101 - T 13-10-2018 IPR033749 Polyprenyl synthetase, conserved site TOPB45_0180 f2acfd5db8d60c647fba38cb221c32e7 328 Pfam PF00348 Polyprenyl synthetase 31 278 6.8E-68 T 13-10-2018 IPR000092 Polyprenyl synthetase GO:0008299 TOPB45_0180 f2acfd5db8d60c647fba38cb221c32e7 328 SUPERFAMILY SSF48576 6 327 1.02E-85 T 13-10-2018 IPR008949 Isoprenoid synthase domain superfamily TOPB45_0180 f2acfd5db8d60c647fba38cb221c32e7 328 Gene3D G3DSA:1.10.600.10 2 328 3.7E-97 T 13-10-2018 IPR008949 Isoprenoid synthase domain superfamily TOPB45_0597 8b404bb4b811027eb04a6e83f01c5012 489 Hamap MF_00120 Glutamyl-tRNA(Gln) amidotransferase subunit A [gatA]. 14 479 92.58 T 13-10-2018 IPR004412 Glutamyl-tRNA(Gln) amidotransferase A subunit GO:0006412|GO:0030956|GO:0050567 KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 TOPB45_0597 8b404bb4b811027eb04a6e83f01c5012 489 Gene3D G3DSA:3.90.1300.10 6 486 3.5E-186 T 13-10-2018 IPR036928 Amidase signature (AS) superfamily KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 TOPB45_0597 8b404bb4b811027eb04a6e83f01c5012 489 SUPERFAMILY SSF75304 3 477 7.33E-159 T 13-10-2018 IPR036928 Amidase signature (AS) superfamily KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 TOPB45_0597 8b404bb4b811027eb04a6e83f01c5012 489 PIRSF PIRSF001221 2 451 8.8E-40 T 13-10-2018 TOPB45_0597 8b404bb4b811027eb04a6e83f01c5012 489 PIRSF PIRSF001221 446 480 3.2E-4 T 13-10-2018 TOPB45_0597 8b404bb4b811027eb04a6e83f01c5012 489 ProSitePatterns PS00571 Amidases signature. 154 185 - T 13-10-2018 IPR020556 Amidase, conserved site KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921|Reactome: R-HSA-2142753 TOPB45_0597 8b404bb4b811027eb04a6e83f01c5012 489 TIGRFAM TIGR00132 gatA: aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, A subunit 17 479 4.0E-193 T 13-10-2018 IPR004412 Glutamyl-tRNA(Gln) amidotransferase A subunit GO:0006412|GO:0030956|GO:0050567 KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 TOPB45_0597 8b404bb4b811027eb04a6e83f01c5012 489 Pfam PF01425 Amidase 27 468 6.3E-160 T 13-10-2018 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 TOPB45_1083 3355e9b75b8250d07024db70ea7f2a8d 325 SMART SM00267 2 153 4.3E-5 T 13-10-2018 IPR000160 GGDEF domain TOPB45_1083 3355e9b75b8250d07024db70ea7f2a8d 325 SUPERFAMILY SSF141868 191 310 3.53E-15 T 13-10-2018 IPR035919 EAL domain superfamily TOPB45_1083 3355e9b75b8250d07024db70ea7f2a8d 325 Pfam PF00990 Diguanylate cyclase, GGDEF domain 29 146 5.5E-13 T 13-10-2018 IPR000160 GGDEF domain TOPB45_1083 3355e9b75b8250d07024db70ea7f2a8d 325 Gene3D G3DSA:3.30.70.270 4 160 9.3E-20 T 13-10-2018 TOPB45_1083 3355e9b75b8250d07024db70ea7f2a8d 325 SUPERFAMILY SSF55073 18 155 9.42E-19 T 13-10-2018 IPR029787 Nucleotide cyclase TOPB45_1083 3355e9b75b8250d07024db70ea7f2a8d 325 TIGRFAM TIGR00254 GGDEF: diguanylate cyclase (GGDEF) domain 28 152 5.7E-15 T 13-10-2018 IPR000160 GGDEF domain TOPB45_1083 3355e9b75b8250d07024db70ea7f2a8d 325 Gene3D G3DSA:3.20.20.450 189 316 9.7E-17 T 13-10-2018 IPR035919 EAL domain superfamily TOPB45_1083 3355e9b75b8250d07024db70ea7f2a8d 325 Pfam PF00563 EAL domain 191 304 6.5E-13 T 13-10-2018 IPR001633 EAL domain TOPB45_0684 dc3f342bc4b474577ee5c035f0b165cc 215 SUPERFAMILY SSF89392 25 210 9.81E-33 T 13-10-2018 IPR029046 Lipoprotein localisation LolA/LolB/LppX TOPB45_0684 dc3f342bc4b474577ee5c035f0b165cc 215 Gene3D G3DSA:2.50.20.10 25 210 1.3E-38 T 13-10-2018 TOPB45_0684 dc3f342bc4b474577ee5c035f0b165cc 215 Pfam PF03548 Outer membrane lipoprotein carrier protein LolA 36 200 5.0E-29 T 13-10-2018 IPR004564 Outer membrane lipoprotein carrier protein LolA-like TOPB45_1284 b63fc2c94bcd7a5fe96e9bec3f00984c 690 Pfam PF02092 Glycyl-tRNA synthetase beta subunit 5 551 1.2E-176 T 13-10-2018 IPR015944 Glycine-tRNA ligase, beta subunit GO:0000166|GO:0004820|GO:0005524|GO:0005737|GO:0006426 KEGG: 00970+6.1.1.14 TOPB45_1284 b63fc2c94bcd7a5fe96e9bec3f00984c 690 SUPERFAMILY SSF109604 337 491 7.69E-8 T 13-10-2018 TOPB45_1284 b63fc2c94bcd7a5fe96e9bec3f00984c 690 Pfam PF05746 DALR anticodon binding domain 584 677 2.7E-8 T 13-10-2018 IPR008909 DALR anticodon binding GO:0004814|GO:0005524|GO:0006420 TOPB45_1284 b63fc2c94bcd7a5fe96e9bec3f00984c 690 Hamap MF_00255 Glycine--tRNA ligase beta subunit [glyS]. 2 689 22.978 T 13-10-2018 IPR015944 Glycine-tRNA ligase, beta subunit GO:0000166|GO:0004820|GO:0005524|GO:0005737|GO:0006426 KEGG: 00970+6.1.1.14 TOPB45_1284 b63fc2c94bcd7a5fe96e9bec3f00984c 690 TIGRFAM TIGR00211 glyS: glycine--tRNA ligase, beta subunit 3 689 2.5E-187 T 13-10-2018 IPR015944 Glycine-tRNA ligase, beta subunit GO:0000166|GO:0004820|GO:0005524|GO:0005737|GO:0006426 KEGG: 00970+6.1.1.14 TOPB45_1284 b63fc2c94bcd7a5fe96e9bec3f00984c 690 PRINTS PR01045 Glycyl-tRNA synthetase beta subunit signature 6 19 2.7E-29 T 13-10-2018 IPR015944 Glycine-tRNA ligase, beta subunit GO:0000166|GO:0004820|GO:0005524|GO:0005737|GO:0006426 KEGG: 00970+6.1.1.14 TOPB45_1284 b63fc2c94bcd7a5fe96e9bec3f00984c 690 PRINTS PR01045 Glycyl-tRNA synthetase beta subunit signature 49 61 2.7E-29 T 13-10-2018 IPR015944 Glycine-tRNA ligase, beta subunit GO:0000166|GO:0004820|GO:0005524|GO:0005737|GO:0006426 KEGG: 00970+6.1.1.14 TOPB45_1284 b63fc2c94bcd7a5fe96e9bec3f00984c 690 PRINTS PR01045 Glycyl-tRNA synthetase beta subunit signature 245 260 2.7E-29 T 13-10-2018 IPR015944 Glycine-tRNA ligase, beta subunit GO:0000166|GO:0004820|GO:0005524|GO:0005737|GO:0006426 KEGG: 00970+6.1.1.14 TOPB45_1284 b63fc2c94bcd7a5fe96e9bec3f00984c 690 PRINTS PR01045 Glycyl-tRNA synthetase beta subunit signature 395 414 2.7E-29 T 13-10-2018 IPR015944 Glycine-tRNA ligase, beta subunit GO:0000166|GO:0004820|GO:0005524|GO:0005737|GO:0006426 KEGG: 00970+6.1.1.14 TOPB45_1284 b63fc2c94bcd7a5fe96e9bec3f00984c 690 PRINTS PR01045 Glycyl-tRNA synthetase beta subunit signature 317 333 2.7E-29 T 13-10-2018 IPR015944 Glycine-tRNA ligase, beta subunit GO:0000166|GO:0004820|GO:0005524|GO:0005737|GO:0006426 KEGG: 00970+6.1.1.14 TOPB45_1563 fe2b43edee870823d68b6e63fcf73943 410 SUPERFAMILY SSF69304 144 407 1.57E-35 T 13-10-2018 TOPB45_1563 fe2b43edee870823d68b6e63fcf73943 410 Pfam PF07676 WD40-like Beta Propeller Repeat 315 343 0.013 T 13-10-2018 IPR011659 WD40-like Beta Propeller TOPB45_1563 fe2b43edee870823d68b6e63fcf73943 410 Gene3D G3DSA:2.120.10.30 151 408 1.3E-37 T 13-10-2018 IPR011042 Six-bladed beta-propeller, TolB-like TOPB45_0521 2d9cdbb122896b4a3996650510fb6362 236 Gene3D G3DSA:1.20.5.170 55 106 1.7E-9 T 13-10-2018 TOPB45_0529 f00df99436b3a448ddf486566e433c83 382 Gene3D G3DSA:3.60.70.12 1 255 1.6E-94 T 13-10-2018 IPR016117 ArgJ-like domain superfamily KEGG: 00220+2.3.1.35+2.3.1.1|MetaCyc: PWY-5154 TOPB45_0529 f00df99436b3a448ddf486566e433c83 382 Hamap MF_01106 Arginine biosynthesis bifunctional protein ArgJ [argJ]. 1 382 118.178 T 13-10-2018 IPR002813 Arginine biosynthesis protein ArgJ GO:0004358|GO:0006526 KEGG: 00220+2.3.1.35+2.3.1.1|MetaCyc: PWY-5154 TOPB45_0529 f00df99436b3a448ddf486566e433c83 382 ProDom PD004193 ACETYLTRANSFERASE ORNITHINE ARGININE BIOSYNTHESIS ARGJ GLUTAMATE N-ACETYLTRANSFERASE TRANSFERASE ACYLTRANSFERASE BIFUNCTIONAL 15 380 2.0E-81 T 13-10-2018 TOPB45_0529 f00df99436b3a448ddf486566e433c83 382 Pfam PF01960 ArgJ family 10 382 9.0E-134 T 13-10-2018 IPR002813 Arginine biosynthesis protein ArgJ GO:0004358|GO:0006526 KEGG: 00220+2.3.1.35+2.3.1.1|MetaCyc: PWY-5154 TOPB45_0529 f00df99436b3a448ddf486566e433c83 382 TIGRFAM TIGR00120 ArgJ: glutamate N-acetyltransferase/amino-acid acetyltransferase 3 382 1.1E-122 T 13-10-2018 IPR002813 Arginine biosynthesis protein ArgJ GO:0004358|GO:0006526 KEGG: 00220+2.3.1.35+2.3.1.1|MetaCyc: PWY-5154 TOPB45_0529 f00df99436b3a448ddf486566e433c83 382 SUPERFAMILY SSF56266 3 378 1.7E-128 T 13-10-2018 IPR016117 ArgJ-like domain superfamily KEGG: 00220+2.3.1.35+2.3.1.1|MetaCyc: PWY-5154 TOPB45_0529 f00df99436b3a448ddf486566e433c83 382 Gene3D G3DSA:3.10.20.340 256 382 3.5E-40 T 13-10-2018 TOPB45_0154 aef361144cf733723f01e9505308419a 159 Pfam PF01613 Flavin reductase like domain 11 149 2.4E-35 T 13-10-2018 IPR002563 Flavin reductase like domain GO:0010181 TOPB45_0154 aef361144cf733723f01e9505308419a 159 SMART SM00903 11 155 1.1E-40 T 13-10-2018 IPR002563 Flavin reductase like domain GO:0010181 TOPB45_0154 aef361144cf733723f01e9505308419a 159 Gene3D G3DSA:2.30.110.10 2 150 4.2E-46 T 13-10-2018 IPR012349 FMN-binding split barrel GO:0048037 TOPB45_0154 aef361144cf733723f01e9505308419a 159 SUPERFAMILY SSF50475 9 153 6.87E-48 T 13-10-2018 TOPB45_0338 589631659245e5799d5ea7eb73791e81 382 TIGRFAM TIGR00031 UDP-GALP_mutase: UDP-galactopyranose mutase 2 381 1.2E-149 T 13-10-2018 IPR004379 UDP-galactopyranose mutase GO:0008767 KEGG: 00052+5.4.99.9|KEGG: 00520+5.4.99.9|MetaCyc: PWY-6397|MetaCyc: PWY-7328|MetaCyc: PWY-7622 TOPB45_0338 589631659245e5799d5ea7eb73791e81 382 Pfam PF03275 UDP-galactopyranose mutase 151 363 2.1E-76 T 13-10-2018 IPR015899 UDP-galactopyranose mutase, C-terminal GO:0008767 KEGG: 00052+5.4.99.9|KEGG: 00520+5.4.99.9|MetaCyc: PWY-6397|MetaCyc: PWY-7328|MetaCyc: PWY-7622 TOPB45_0338 589631659245e5799d5ea7eb73791e81 382 Gene3D G3DSA:3.40.50.720 146 286 6.1E-30 T 13-10-2018 TOPB45_0338 589631659245e5799d5ea7eb73791e81 382 Gene3D G3DSA:3.40.50.720 296 381 4.0E-16 T 13-10-2018 TOPB45_0338 589631659245e5799d5ea7eb73791e81 382 Gene3D G3DSA:3.40.50.720 1 87 2.7E-30 T 13-10-2018 TOPB45_0338 589631659245e5799d5ea7eb73791e81 382 SUPERFAMILY SSF51971 5 377 1.41E-44 T 13-10-2018 TOPB45_0338 589631659245e5799d5ea7eb73791e81 382 SUPERFAMILY SSF54373 262 330 2.94E-20 T 13-10-2018 TOPB45_0338 589631659245e5799d5ea7eb73791e81 382 Pfam PF13450 NAD(P)-binding Rossmann-like domain 6 72 1.5E-17 T 13-10-2018 TOPB45_1566 2bedc04f13984cd79cb7c1ceea4661fc 109 SUPERFAMILY SSF140566 6 83 7.98E-6 T 13-10-2018 IPR036679 FlgN-like superfamily GO:0005515|GO:0044780 TOPB45_0853 9802689f8ace21a96904a4e141b2d379 272 Pfam PF03544 Gram-negative bacterial TonB protein C-terminal 192 266 3.7E-19 T 13-10-2018 IPR037682 TonB, C-terminal GO:0055085 TOPB45_0853 9802689f8ace21a96904a4e141b2d379 272 TIGRFAM TIGR01352 tonB_Cterm: TonB family C-terminal domain 194 266 1.3E-18 T 13-10-2018 IPR006260 TonB/TolA, C-terminal TOPB45_0853 9802689f8ace21a96904a4e141b2d379 272 Gene3D G3DSA:3.30.1150.10 180 269 6.5E-22 T 13-10-2018 TOPB45_0853 9802689f8ace21a96904a4e141b2d379 272 SUPERFAMILY SSF74653 182 267 2.35E-16 T 13-10-2018 TOPB45_0985 aaae964d292af09012afd418348ef32b 591 TIGRFAM TIGR02504 NrdJ_Z: ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent 16 571 2.0E-215 T 13-10-2018 IPR013344 Ribonucleotide reductase, adenosylcobalamin-dependent GO:0000166|GO:0004748|GO:0031419|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|KEGG: 00983+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227 TOPB45_0985 aaae964d292af09012afd418348ef32b 591 SUPERFAMILY SSF51998 92 572 1.1E-153 T 13-10-2018 TOPB45_0985 aaae964d292af09012afd418348ef32b 591 Pfam PF02867 Ribonucleotide reductase, barrel domain 93 561 1.5E-157 T 13-10-2018 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|KEGG: 00983+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 TOPB45_0985 aaae964d292af09012afd418348ef32b 591 Gene3D G3DSA:3.20.70.20 1 574 2.8E-232 T 13-10-2018 TOPB45_0985 aaae964d292af09012afd418348ef32b 591 PRINTS PR01183 Ribonucleotide reductase large chain signature 412 439 3.6E-33 T 13-10-2018 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|KEGG: 00983+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 TOPB45_0985 aaae964d292af09012afd418348ef32b 591 PRINTS PR01183 Ribonucleotide reductase large chain signature 343 365 3.6E-33 T 13-10-2018 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|KEGG: 00983+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 TOPB45_0985 aaae964d292af09012afd418348ef32b 591 PRINTS PR01183 Ribonucleotide reductase large chain signature 168 187 3.6E-33 T 13-10-2018 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|KEGG: 00983+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 TOPB45_0985 aaae964d292af09012afd418348ef32b 591 PRINTS PR01183 Ribonucleotide reductase large chain signature 305 328 3.6E-33 T 13-10-2018 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|KEGG: 00983+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 TOPB45_0985 aaae964d292af09012afd418348ef32b 591 PRINTS PR01183 Ribonucleotide reductase large chain signature 371 394 3.6E-33 T 13-10-2018 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|KEGG: 00983+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 TOPB45_0985 aaae964d292af09012afd418348ef32b 591 Pfam PF00317 Ribonucleotide reductase, all-alpha domain 12 90 1.3E-25 T 13-10-2018 IPR013509 Ribonucleotide reductase large subunit, N-terminal GO:0004748|GO:0005524|GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|KEGG: 00983+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 TOPB45_0985 aaae964d292af09012afd418348ef32b 591 SUPERFAMILY SSF48168 12 91 6.8E-16 T 13-10-2018 IPR008926 Ribonucleotide reductase R1 subunit, N-terminal KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|KEGG: 00983+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 TOPB45_1600 10e7c469c4b4ad5001108df6c4c1806a 389 SUPERFAMILY SSF52922 250 373 2.49E-35 T 13-10-2018 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824 TOPB45_1600 10e7c469c4b4ad5001108df6c4c1806a 389 Pfam PF17147 Pyruvate:ferredoxin oxidoreductase core domain II 259 363 1.8E-28 T 13-10-2018 IPR033412 Pyruvate:ferredoxin oxidoreductase, core domain II TOPB45_1600 10e7c469c4b4ad5001108df6c4c1806a 389 Pfam PF01855 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg 16 233 8.4E-74 T 13-10-2018 IPR002880 Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal GO:0016491|GO:0055114 TOPB45_1600 10e7c469c4b4ad5001108df6c4c1806a 389 SUPERFAMILY SSF52518 11 248 3.06E-68 T 13-10-2018 IPR029061 Thiamin diphosphate-binding fold TOPB45_1600 10e7c469c4b4ad5001108df6c4c1806a 389 Gene3D G3DSA:3.40.50.920 250 385 2.6E-42 T 13-10-2018 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824 TOPB45_1600 10e7c469c4b4ad5001108df6c4c1806a 389 Gene3D G3DSA:3.40.50.970 1 249 2.6E-95 T 13-10-2018 TOPB45_0492 b61e64934bc829fbc28f688b39bd3b77 259 Hamap MF_01013 Imidazole glycerol phosphate synthase subunit HisF [hisF]. 1 256 45.356 T 13-10-2018 IPR004651 Histidine biosynthesis, HisF GO:0000105|GO:0000107|GO:0005737 TOPB45_0492 b61e64934bc829fbc28f688b39bd3b77 259 TIGRFAM TIGR00735 hisF: imidazoleglycerol phosphate synthase, cyclase subunit 1 256 3.9E-111 T 13-10-2018 IPR004651 Histidine biosynthesis, HisF GO:0000105|GO:0000107|GO:0005737 TOPB45_0492 b61e64934bc829fbc28f688b39bd3b77 259 Gene3D G3DSA:3.20.20.70 1 259 1.6E-100 T 13-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 TOPB45_0492 b61e64934bc829fbc28f688b39bd3b77 259 SUPERFAMILY SSF51366 1 257 2.28E-76 T 13-10-2018 IPR011060 Ribulose-phosphate binding barrel GO:0003824 TOPB45_0492 b61e64934bc829fbc28f688b39bd3b77 259 Pfam PF00977 Histidine biosynthesis protein 5 240 8.3E-81 T 13-10-2018 IPR006062 Histidine biosynthesis GO:0000105 TOPB45_0963 6aed030d37a32f35804494bcf8a87c0e 314 TIGRFAM TIGR01444 fkbM_fam: methyltransferase, FkbM family 133 265 2.4E-26 T 13-10-2018 IPR006342 Methyltransferase FkbM TOPB45_0963 6aed030d37a32f35804494bcf8a87c0e 314 SUPERFAMILY SSF53335 26 303 1.43E-52 T 13-10-2018 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TOPB45_0963 6aed030d37a32f35804494bcf8a87c0e 314 Gene3D G3DSA:3.40.50.150 115 305 1.1E-47 T 13-10-2018 TOPB45_0963 6aed030d37a32f35804494bcf8a87c0e 314 Pfam PF05050 Methyltransferase FkbM domain 136 278 7.2E-16 T 13-10-2018 IPR006342 Methyltransferase FkbM TOPB45_0321 943e636d5367d65f534c25b9a5644adb 463 Pfam PF00483 Nucleotidyl transferase 3 279 1.0E-58 T 13-10-2018 IPR005835 Nucleotidyl transferase domain GO:0009058|GO:0016779 TOPB45_0321 943e636d5367d65f534c25b9a5644adb 463 Gene3D G3DSA:3.90.550.10 1 342 1.8E-120 T 13-10-2018 IPR029044 Nucleotide-diphospho-sugar transferases TOPB45_0321 943e636d5367d65f534c25b9a5644adb 463 Gene3D G3DSA:2.60.120.10 346 452 2.3E-19 T 13-10-2018 IPR014710 RmlC-like jelly roll fold TOPB45_0321 943e636d5367d65f534c25b9a5644adb 463 SUPERFAMILY SSF53448 1 272 2.09E-72 T 13-10-2018 IPR029044 Nucleotide-diphospho-sugar transferases TOPB45_0321 943e636d5367d65f534c25b9a5644adb 463 TIGRFAM TIGR01479 GMP_PMI: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase 4 461 1.7E-179 T 13-10-2018 IPR006375 Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase GO:0000271|GO:0016779 KEGG: 00051+2.7.7.13|KEGG: 00520+2.7.7.13|MetaCyc: PWY-5659|MetaCyc: PWY-882 TOPB45_0321 943e636d5367d65f534c25b9a5644adb 463 Pfam PF01050 Mannose-6-phosphate isomerase 308 457 1.4E-68 T 13-10-2018 IPR001538 Mannose-6-phosphate isomerase, type II, C-terminal GO:0005976|GO:0016779 KEGG: 00051+2.7.7.13|KEGG: 00520+2.7.7.13|MetaCyc: PWY-5659|MetaCyc: PWY-882 TOPB45_0321 943e636d5367d65f534c25b9a5644adb 463 SUPERFAMILY SSF51182 187 461 1.5E-78 T 13-10-2018 IPR011051 RmlC-like cupin domain superfamily TOPB45_0375 7ca5b566d64acf8fe1288dd27ca7a273 497 SUPERFAMILY SSF56322 20 491 1.96E-153 T 13-10-2018 IPR005801 ADC synthase GO:0009058 TOPB45_0375 7ca5b566d64acf8fe1288dd27ca7a273 497 TIGRFAM TIGR00564 trpE_most: anthranilate synthase component I 31 490 2.0E-165 T 13-10-2018 IPR005256 Anthranilate synthase component I, PabB-like GO:0000162|GO:0004049 KEGG: 00400+4.1.3.27|KEGG: 00405+4.1.3.27|MetaCyc: PWY-5958|MetaCyc: PWY-6660|MetaCyc: PWY-6661 TOPB45_0375 7ca5b566d64acf8fe1288dd27ca7a273 497 Pfam PF04715 Anthranilate synthase component I, N terminal region 31 173 2.9E-30 T 13-10-2018 IPR006805 Anthranilate synthase component I, N-terminal GO:0009058 KEGG: 00400+4.1.3.27|KEGG: 00405+4.1.3.27|MetaCyc: PWY-5958|MetaCyc: PWY-6660|MetaCyc: PWY-6661 TOPB45_0375 7ca5b566d64acf8fe1288dd27ca7a273 497 Pfam PF00425 chorismate binding enzyme 229 482 1.7E-98 T 13-10-2018 IPR015890 Chorismate-utilising enzyme, C-terminal TOPB45_0375 7ca5b566d64acf8fe1288dd27ca7a273 497 Gene3D G3DSA:3.60.120.10 3 496 6.9E-172 T 13-10-2018 IPR005801 ADC synthase GO:0009058 TOPB45_0375 7ca5b566d64acf8fe1288dd27ca7a273 497 PRINTS PR00095 Anthranilate synthase component I signature 424 438 1.4E-23 T 13-10-2018 IPR019999 Anthranilate synthase component I-like GO:0009058 KEGG: 00400+4.1.3.27|KEGG: 00405+4.1.3.27|MetaCyc: PWY-5958|MetaCyc: PWY-6660|MetaCyc: PWY-6661 TOPB45_0375 7ca5b566d64acf8fe1288dd27ca7a273 497 PRINTS PR00095 Anthranilate synthase component I signature 344 357 1.4E-23 T 13-10-2018 IPR019999 Anthranilate synthase component I-like GO:0009058 KEGG: 00400+4.1.3.27|KEGG: 00405+4.1.3.27|MetaCyc: PWY-5958|MetaCyc: PWY-6660|MetaCyc: PWY-6661 TOPB45_0375 7ca5b566d64acf8fe1288dd27ca7a273 497 PRINTS PR00095 Anthranilate synthase component I signature 330 343 1.4E-23 T 13-10-2018 IPR019999 Anthranilate synthase component I-like GO:0009058 KEGG: 00400+4.1.3.27|KEGG: 00405+4.1.3.27|MetaCyc: PWY-5958|MetaCyc: PWY-6660|MetaCyc: PWY-6661 TOPB45_0375 7ca5b566d64acf8fe1288dd27ca7a273 497 PRINTS PR00095 Anthranilate synthase component I signature 439 453 1.4E-23 T 13-10-2018 IPR019999 Anthranilate synthase component I-like GO:0009058 KEGG: 00400+4.1.3.27|KEGG: 00405+4.1.3.27|MetaCyc: PWY-5958|MetaCyc: PWY-6660|MetaCyc: PWY-6661 TOPB45_0797 272ed11a0787e23f0f382c0657473d5f 517 SUPERFAMILY SSF88659 353 427 7.19E-16 T 13-10-2018 IPR013324 RNA polymerase sigma factor, region 3/4-like TOPB45_0797 272ed11a0787e23f0f382c0657473d5f 517 Pfam PF04539 Sigma-70 region 3 359 436 3.8E-17 T 13-10-2018 IPR007624 RNA polymerase sigma-70 region 3 GO:0003700|GO:0006352|GO:0006355 TOPB45_0797 272ed11a0787e23f0f382c0657473d5f 517 Gene3D G3DSA:1.10.10.10 353 429 1.3E-22 T 13-10-2018 IPR036388 Winged helix-like DNA-binding domain superfamily TOPB45_0797 272ed11a0787e23f0f382c0657473d5f 517 Gene3D G3DSA:1.10.10.10 431 514 9.4E-31 T 13-10-2018 IPR036388 Winged helix-like DNA-binding domain superfamily TOPB45_0797 272ed11a0787e23f0f382c0657473d5f 517 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 278 502 2.4E-37 T 13-10-2018 IPR014284 RNA polymerase sigma-70 like domain GO:0003700|GO:0006352|GO:0006355 TOPB45_0797 272ed11a0787e23f0f382c0657473d5f 517 SUPERFAMILY SSF88659 412 504 2.05E-24 T 13-10-2018 IPR013324 RNA polymerase sigma factor, region 3/4-like TOPB45_0797 272ed11a0787e23f0f382c0657473d5f 517 ProSitePatterns PS00715 Sigma-70 factors family signature 1. 304 317 - T 13-10-2018 IPR000943 RNA polymerase sigma-70 GO:0003700|GO:0006352|GO:0006355 TOPB45_0797 272ed11a0787e23f0f382c0657473d5f 517 Pfam PF04545 Sigma-70, region 4 449 502 2.1E-17 T 13-10-2018 IPR007630 RNA polymerase sigma-70 region 4 GO:0003700|GO:0006352|GO:0006355 TOPB45_0797 272ed11a0787e23f0f382c0657473d5f 517 Pfam PF00140 Sigma-70 factor, region 1.2 47 79 1.5E-6 T 13-10-2018 IPR009042 RNA polymerase sigma-70 region 1.2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 TOPB45_0797 272ed11a0787e23f0f382c0657473d5f 517 Gene3D G3DSA:1.10.601.10 45 352 3.3E-68 T 13-10-2018 TOPB45_0797 272ed11a0787e23f0f382c0657473d5f 517 SUPERFAMILY SSF88946 64 347 3.77E-46 T 13-10-2018 IPR013325 RNA polymerase sigma factor, region 2 GO:0003700|GO:0006352|GO:0006355 TOPB45_0797 272ed11a0787e23f0f382c0657473d5f 517 Pfam PF04542 Sigma-70 region 2 280 349 5.8E-20 T 13-10-2018 IPR007627 RNA polymerase sigma-70 region 2 GO:0003700|GO:0006352|GO:0006355 TOPB45_0797 272ed11a0787e23f0f382c0657473d5f 517 ProSitePatterns PS00716 Sigma-70 factors family signature 2. 474 500 - T 13-10-2018 IPR000943 RNA polymerase sigma-70 GO:0003700|GO:0006352|GO:0006355 TOPB45_0797 272ed11a0787e23f0f382c0657473d5f 517 PRINTS PR00046 Major sigma-70 factor signature 474 489 2.4E-29 T 13-10-2018 IPR000943 RNA polymerase sigma-70 GO:0003700|GO:0006352|GO:0006355 TOPB45_0797 272ed11a0787e23f0f382c0657473d5f 517 PRINTS PR00046 Major sigma-70 factor signature 489 500 2.4E-29 T 13-10-2018 IPR000943 RNA polymerase sigma-70 GO:0003700|GO:0006352|GO:0006355 TOPB45_0797 272ed11a0787e23f0f382c0657473d5f 517 PRINTS PR00046 Major sigma-70 factor signature 328 336 2.4E-29 T 13-10-2018 IPR000943 RNA polymerase sigma-70 GO:0003700|GO:0006352|GO:0006355 TOPB45_0797 272ed11a0787e23f0f382c0657473d5f 517 PRINTS PR00046 Major sigma-70 factor signature 304 317 2.4E-29 T 13-10-2018 IPR000943 RNA polymerase sigma-70 GO:0003700|GO:0006352|GO:0006355 TOPB45_0797 272ed11a0787e23f0f382c0657473d5f 517 PRINTS PR00046 Major sigma-70 factor signature 453 465 2.4E-29 T 13-10-2018 IPR000943 RNA polymerase sigma-70 GO:0003700|GO:0006352|GO:0006355 TOPB45_0406 5f461d0433d398c85e49dcf30bcb3a41 152 PRINTS PR01438 Universal stress protein signature 123 145 5.5E-14 T 13-10-2018 IPR006015 Universal stress protein A TOPB45_0406 5f461d0433d398c85e49dcf30bcb3a41 152 PRINTS PR01438 Universal stress protein signature 105 117 5.5E-14 T 13-10-2018 IPR006015 Universal stress protein A TOPB45_0406 5f461d0433d398c85e49dcf30bcb3a41 152 PRINTS PR01438 Universal stress protein signature 4 22 5.5E-14 T 13-10-2018 IPR006015 Universal stress protein A TOPB45_0406 5f461d0433d398c85e49dcf30bcb3a41 152 Gene3D G3DSA:3.40.50.620 1 151 2.9E-35 T 13-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TOPB45_0406 5f461d0433d398c85e49dcf30bcb3a41 152 SUPERFAMILY SSF52402 4 145 5.23E-33 T 13-10-2018 TOPB45_0406 5f461d0433d398c85e49dcf30bcb3a41 152 PIRSF PIRSF006276 2 147 7.6E-21 T 13-10-2018 IPR006015 Universal stress protein A TOPB45_0406 5f461d0433d398c85e49dcf30bcb3a41 152 Pfam PF00582 Universal stress protein family 4 143 5.6E-28 T 13-10-2018 IPR006016 UspA TOPB45_0071 d08af8d818a2893d48cab4799ba3e29f 350 Pfam PF01594 AI-2E family transporter 10 344 4.2E-57 T 13-10-2018 IPR002549 Transmembrane protein TqsA-like TOPB45_0883 93487dc4ade6f6bd6ac146be9fedab06 79 Gene3D G3DSA:2.40.50.970 1 76 1.7E-27 T 13-10-2018 IPR037254 HupF/HypC superfamily TOPB45_0883 93487dc4ade6f6bd6ac146be9fedab06 79 SUPERFAMILY SSF159127 1 73 2.75E-24 T 13-10-2018 IPR037254 HupF/HypC superfamily TOPB45_0883 93487dc4ade6f6bd6ac146be9fedab06 79 TIGRFAM TIGR00074 hypC_hupF: hydrogenase assembly chaperone HypC/HupF 1 75 2.7E-24 T 13-10-2018 IPR001109 Hydrogenase expression/formation protein, HupF/HypC TOPB45_0883 93487dc4ade6f6bd6ac146be9fedab06 79 Pfam PF01455 HupF/HypC family 1 67 2.0E-25 T 13-10-2018 IPR001109 Hydrogenase expression/formation protein, HupF/HypC TOPB45_0883 93487dc4ade6f6bd6ac146be9fedab06 79 PRINTS PR00445 HupF/HypC hydrogenase expression/synthesis family signature 18 34 4.8E-13 T 13-10-2018 IPR001109 Hydrogenase expression/formation protein, HupF/HypC TOPB45_0883 93487dc4ade6f6bd6ac146be9fedab06 79 PRINTS PR00445 HupF/HypC hydrogenase expression/synthesis family signature 58 70 4.8E-13 T 13-10-2018 IPR001109 Hydrogenase expression/formation protein, HupF/HypC TOPB45_0883 93487dc4ade6f6bd6ac146be9fedab06 79 PRINTS PR00445 HupF/HypC hydrogenase expression/synthesis family signature 40 56 4.8E-13 T 13-10-2018 IPR001109 Hydrogenase expression/formation protein, HupF/HypC TOPB45_0883 93487dc4ade6f6bd6ac146be9fedab06 79 PRINTS PR00445 HupF/HypC hydrogenase expression/synthesis family signature 2 9 4.8E-13 T 13-10-2018 IPR001109 Hydrogenase expression/formation protein, HupF/HypC TOPB45_0290 ec1775d373d14068e027f06da5c66de2 239 Pfam PF00303 Thymidylate synthase 112 236 4.4E-12 T 13-10-2018 IPR023451 Thymidylate synthase/dCMP hydroxymethylase domain KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|Reactome: R-HSA-499943|Reactome: R-HSA-539107 TOPB45_0290 ec1775d373d14068e027f06da5c66de2 239 Gene3D G3DSA:3.30.572.10 78 239 3.2E-21 T 13-10-2018 IPR036926 Thymidylate synthase/dCMP hydroxymethylase superfamily KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|Reactome: R-HSA-499943|Reactome: R-HSA-539107 TOPB45_0290 ec1775d373d14068e027f06da5c66de2 239 SUPERFAMILY SSF55831 15 236 4.19E-25 T 13-10-2018 IPR036926 Thymidylate synthase/dCMP hydroxymethylase superfamily KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|Reactome: R-HSA-499943|Reactome: R-HSA-539107 TOPB45_1330 ad172800663ccd79ba12af449702db48 366 PRINTS PR00950 Type III secretion system inner membrane S protein family signature 302 323 1.6E-33 T 13-10-2018 IPR006135 Type III secretion system substrate exporter GO:0009306|GO:0016020 TOPB45_1330 ad172800663ccd79ba12af449702db48 366 PRINTS PR00950 Type III secretion system inner membrane S protein family signature 10 32 1.6E-33 T 13-10-2018 IPR006135 Type III secretion system substrate exporter GO:0009306|GO:0016020 TOPB45_1330 ad172800663ccd79ba12af449702db48 366 PRINTS PR00950 Type III secretion system inner membrane S protein family signature 272 287 1.6E-33 T 13-10-2018 IPR006135 Type III secretion system substrate exporter GO:0009306|GO:0016020 TOPB45_1330 ad172800663ccd79ba12af449702db48 366 PRINTS PR00950 Type III secretion system inner membrane S protein family signature 228 245 1.6E-33 T 13-10-2018 IPR006135 Type III secretion system substrate exporter GO:0009306|GO:0016020 TOPB45_1330 ad172800663ccd79ba12af449702db48 366 PRINTS PR00950 Type III secretion system inner membrane S protein family signature 208 226 1.6E-33 T 13-10-2018 IPR006135 Type III secretion system substrate exporter GO:0009306|GO:0016020 TOPB45_1330 ad172800663ccd79ba12af449702db48 366 SUPERFAMILY SSF160544 244 351 4.84E-41 T 13-10-2018 IPR029025 Type III secretion system substrate exporter, C-terminal TOPB45_1330 ad172800663ccd79ba12af449702db48 366 TIGRFAM TIGR00328 flhB: flagellar biosynthetic protein FlhB 7 353 1.8E-114 T 13-10-2018 IPR006136 Flagellar biosynthetic protein FlhB GO:0015031|GO:0016021|GO:0044780 TOPB45_1330 ad172800663ccd79ba12af449702db48 366 Gene3D G3DSA:3.40.1690.10 218 358 2.9E-53 T 13-10-2018 IPR029025 Type III secretion system substrate exporter, C-terminal TOPB45_1330 ad172800663ccd79ba12af449702db48 366 Pfam PF01312 FlhB HrpN YscU SpaS Family 7 347 8.3E-120 T 13-10-2018 IPR006135 Type III secretion system substrate exporter GO:0009306|GO:0016020 TOPB45_0839 e82f802f8a566310352ffcb4f28f89b4 403 Gene3D G3DSA:1.20.81.30 253 363 3.3E-27 T 13-10-2018 TOPB45_0839 e82f802f8a566310352ffcb4f28f89b4 403 Gene3D G3DSA:1.20.81.30 51 168 2.8E-34 T 13-10-2018 TOPB45_0839 e82f802f8a566310352ffcb4f28f89b4 403 Pfam PF00482 Type II secretion system (T2SS), protein F 66 189 1.7E-32 T 13-10-2018 IPR018076 Type II secretion system F domain TOPB45_0839 e82f802f8a566310352ffcb4f28f89b4 403 Pfam PF00482 Type II secretion system (T2SS), protein F 270 391 1.4E-25 T 13-10-2018 IPR018076 Type II secretion system F domain TOPB45_0839 e82f802f8a566310352ffcb4f28f89b4 403 PRINTS PR00812 Bacterial general secretion pathway protein F signature 380 399 9.5E-19 T 13-10-2018 IPR003004 GspF/PilC family TOPB45_0839 e82f802f8a566310352ffcb4f28f89b4 403 PRINTS PR00812 Bacterial general secretion pathway protein F signature 62 74 9.5E-19 T 13-10-2018 IPR003004 GspF/PilC family TOPB45_0839 e82f802f8a566310352ffcb4f28f89b4 403 PRINTS PR00812 Bacterial general secretion pathway protein F signature 161 189 9.5E-19 T 13-10-2018 IPR003004 GspF/PilC family TOPB45_0839 e82f802f8a566310352ffcb4f28f89b4 403 PRINTS PR00812 Bacterial general secretion pathway protein F signature 364 378 9.5E-19 T 13-10-2018 IPR003004 GspF/PilC family TOPB45_1277 c54b6d92825d54742aa992a0e0d66fce 606 SUPERFAMILY SSF54534 369 452 1.57E-5 T 13-10-2018 TOPB45_1277 c54b6d92825d54742aa992a0e0d66fce 606 Pfam PF13145 PPIC-type PPIASE domain 366 463 4.3E-9 T 13-10-2018 IPR000297 Peptidyl-prolyl cis-trans isomerase, PpiC-type GO:0003755 TOPB45_1277 c54b6d92825d54742aa992a0e0d66fce 606 Pfam PF13145 PPIC-type PPIASE domain 241 356 9.8E-14 T 13-10-2018 IPR000297 Peptidyl-prolyl cis-trans isomerase, PpiC-type GO:0003755 TOPB45_1277 c54b6d92825d54742aa992a0e0d66fce 606 SUPERFAMILY SSF54534 263 346 1.77E-7 T 13-10-2018 TOPB45_1277 c54b6d92825d54742aa992a0e0d66fce 606 Gene3D G3DSA:3.10.50.40 368 473 1.5E-6 T 13-10-2018 TOPB45_1277 c54b6d92825d54742aa992a0e0d66fce 606 Pfam PF13624 SurA N-terminal domain 1 160 5.0E-47 T 13-10-2018 TOPB45_1277 c54b6d92825d54742aa992a0e0d66fce 606 Gene3D G3DSA:3.10.50.40 261 345 5.2E-12 T 13-10-2018 TOPB45_1277 c54b6d92825d54742aa992a0e0d66fce 606 Gene3D G3DSA:1.10.4030.30 237 367 5.2E-12 T 13-10-2018 TOPB45_1277 c54b6d92825d54742aa992a0e0d66fce 606 SUPERFAMILY SSF109998 39 183 2.16E-26 T 13-10-2018 IPR027304 Trigger factor/SurA domain superfamily TOPB45_1277 c54b6d92825d54742aa992a0e0d66fce 606 Gene3D G3DSA:1.10.4030.30 41 185 4.0E-18 T 13-10-2018 TOPB45_1175 18c7df759e5a67829dc57aaf2b480b41 211 SMART SM00481 2 74 3.7E-15 T 13-10-2018 IPR003141 Polymerase/histidinol phosphatase, N-terminal TOPB45_1175 18c7df759e5a67829dc57aaf2b480b41 211 Pfam PF02811 PHP domain 3 74 3.9E-7 T 13-10-2018 IPR004013 PHP domain GO:0003824 TOPB45_1175 18c7df759e5a67829dc57aaf2b480b41 211 SUPERFAMILY SSF89550 9 205 1.57E-40 T 13-10-2018 IPR016195 Polymerase/histidinol phosphatase-like GO:0003824 Reactome: R-HSA-6784531|Reactome: R-HSA-6791226 TOPB45_1175 18c7df759e5a67829dc57aaf2b480b41 211 Gene3D G3DSA:3.20.20.140 1 209 5.4E-27 T 13-10-2018 TOPB45_1398 4e64c749edf2d1da323ffe40538ddc96 563 SUPERFAMILY SSF52518 369 561 2.03E-69 T 13-10-2018 IPR029061 Thiamin diphosphate-binding fold TOPB45_1398 4e64c749edf2d1da323ffe40538ddc96 563 Gene3D G3DSA:3.40.50.1220 191 360 1.7E-139 T 13-10-2018 TOPB45_1398 4e64c749edf2d1da323ffe40538ddc96 563 Pfam PF02776 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain 1 166 6.0E-59 T 13-10-2018 IPR012001 Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain GO:0030976 TOPB45_1398 4e64c749edf2d1da323ffe40538ddc96 563 Pfam PF02775 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain 392 539 1.5E-51 T 13-10-2018 IPR011766 Thiamine pyrophosphate enzyme, C-terminal TPP-binding GO:0003824|GO:0030976 TOPB45_1398 4e64c749edf2d1da323ffe40538ddc96 563 Gene3D G3DSA:3.40.50.970 1 183 1.4E-71 T 13-10-2018 TOPB45_1398 4e64c749edf2d1da323ffe40538ddc96 563 SUPERFAMILY SSF52518 1 179 1.51E-64 T 13-10-2018 IPR029061 Thiamin diphosphate-binding fold TOPB45_1398 4e64c749edf2d1da323ffe40538ddc96 563 TIGRFAM TIGR00118 acolac_lg: acetolactate synthase, large subunit, biosynthetic type 1 562 8.8E-267 T 13-10-2018 IPR012846 Acetolactate synthase, large subunit, biosynthetic GO:0000287|GO:0003984|GO:0009082|GO:0030976|GO:0050660 KEGG: 00290+2.2.1.6|KEGG: 00650+2.2.1.6|KEGG: 00660+2.2.1.6|KEGG: 00770+2.2.1.6|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-5938|MetaCyc: PWY-5939|MetaCyc: PWY-6389|MetaCyc: PWY-7111 TOPB45_1398 4e64c749edf2d1da323ffe40538ddc96 563 ProSitePatterns PS00187 Thiamine pyrophosphate enzymes signature. 428 447 - T 13-10-2018 IPR000399 TPP-binding enzyme, conserved site GO:0000287|GO:0030976 TOPB45_1398 4e64c749edf2d1da323ffe40538ddc96 563 SUPERFAMILY SSF52467 183 360 8.73E-68 T 13-10-2018 IPR029035 DHS-like NAD/FAD-binding domain superfamily TOPB45_1398 4e64c749edf2d1da323ffe40538ddc96 563 Gene3D G3DSA:3.40.50.970 361 539 1.7E-139 T 13-10-2018 TOPB45_1398 4e64c749edf2d1da323ffe40538ddc96 563 Pfam PF00205 Thiamine pyrophosphate enzyme, central domain 191 325 3.0E-48 T 13-10-2018 IPR012000 Thiamine pyrophosphate enzyme, central domain GO:0000287|GO:0030976 TOPB45_0587 f2e952c4da8ca50b9c93532736a799b1 44 Hamap MF_00391 50S ribosomal protein L34 [rpmH]. 1 44 16.38 T 13-10-2018 IPR000271 Ribosomal protein L34 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0587 f2e952c4da8ca50b9c93532736a799b1 44 Pfam PF00468 Ribosomal protein L34 1 44 5.7E-22 T 13-10-2018 IPR000271 Ribosomal protein L34 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0587 f2e952c4da8ca50b9c93532736a799b1 44 ProDom PD003101 RIBOSOMAL L34 RIBONUCLEOPROTEIN 50S CHLOROPLAST PLASTID L34 MITOCHONDRIAL PEPTIDE SEQUENCING 1 24 4.0E-4 T 13-10-2018 IPR000271 Ribosomal protein L34 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0587 f2e952c4da8ca50b9c93532736a799b1 44 TIGRFAM TIGR01030 rpmH_bact: ribosomal protein bL34 1 44 5.9E-21 T 13-10-2018 IPR000271 Ribosomal protein L34 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_1365 0c939beb00d20c9206b39f7bc1ed06f1 280 TIGRFAM TIGR01496 DHPS: dihydropteroate synthase 21 276 1.4E-103 T 13-10-2018 IPR006390 Dihydropteroate synthase GO:0004156|GO:0009396 KEGG: 00790+2.5.1.15|MetaCyc: PWY-6614 TOPB45_1365 0c939beb00d20c9206b39f7bc1ed06f1 280 ProSitePatterns PS00793 Dihydropteroate synthase signature 2. 54 67 - T 13-10-2018 IPR000489 Pterin-binding domain GO:0042558 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 TOPB45_1365 0c939beb00d20c9206b39f7bc1ed06f1 280 Gene3D G3DSA:3.20.20.20 4 280 5.3E-110 T 13-10-2018 IPR011005 Dihydropteroate synthase-like GO:0044237 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 TOPB45_1365 0c939beb00d20c9206b39f7bc1ed06f1 280 SUPERFAMILY SSF51717 8 278 8.11E-102 T 13-10-2018 IPR011005 Dihydropteroate synthase-like GO:0044237 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 TOPB45_1365 0c939beb00d20c9206b39f7bc1ed06f1 280 Pfam PF00809 Pterin binding enzyme 22 262 2.2E-90 T 13-10-2018 IPR000489 Pterin-binding domain GO:0042558 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 TOPB45_1121 c3271309f98617a93948c9ae32038359 120 Pfam PF06094 Gamma-glutamyl cyclotransferase, AIG2-like 4 115 5.6E-24 T 13-10-2018 IPR009288 Gamma-glutamylcyclotransferase, AIG2-like TOPB45_1121 c3271309f98617a93948c9ae32038359 120 SUPERFAMILY SSF110857 1 117 5.62E-32 T 13-10-2018 IPR036568 Gamma-glutamyl cyclotransferase-like superfamily TOPB45_1121 c3271309f98617a93948c9ae32038359 120 Gene3D G3DSA:3.10.490.10 3 120 1.1E-33 T 13-10-2018 TOPB45_1531 726c57001488aaf09ca519ad929ad8f6 1221 Pfam PF13109 AsmA-like C-terminal region 1035 1162 1.4E-8 T 13-10-2018 IPR039441 AsmA-like C-terminal region TOPB45_1501 e21437bf14616bfe05e34fc9ae8bc5c1 176 PRINTS PR01100 Shikimate kinase family signature 95 112 9.7E-20 T 13-10-2018 TOPB45_1501 e21437bf14616bfe05e34fc9ae8bc5c1 176 PRINTS PR01100 Shikimate kinase family signature 4 19 9.7E-20 T 13-10-2018 TOPB45_1501 e21437bf14616bfe05e34fc9ae8bc5c1 176 PRINTS PR01100 Shikimate kinase family signature 28 41 9.7E-20 T 13-10-2018 TOPB45_1501 e21437bf14616bfe05e34fc9ae8bc5c1 176 PRINTS PR01100 Shikimate kinase family signature 74 83 9.7E-20 T 13-10-2018 TOPB45_1501 e21437bf14616bfe05e34fc9ae8bc5c1 176 PRINTS PR01100 Shikimate kinase family signature 56 64 9.7E-20 T 13-10-2018 TOPB45_1501 e21437bf14616bfe05e34fc9ae8bc5c1 176 Gene3D G3DSA:3.40.50.300 1 176 5.9E-57 T 13-10-2018 TOPB45_1501 e21437bf14616bfe05e34fc9ae8bc5c1 176 ProSitePatterns PS01128 Shikimate kinase signature. 57 82 - T 13-10-2018 IPR023000 Shikimate kinase, conserved site KEGG: 00400+2.7.1.71|MetaCyc: PWY-6163 TOPB45_1501 e21437bf14616bfe05e34fc9ae8bc5c1 176 SUPERFAMILY SSF52540 3 170 2.97E-29 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1501 e21437bf14616bfe05e34fc9ae8bc5c1 176 Hamap MF_00109 Shikimate kinase [aroK]. 1 171 26.438 T 13-10-2018 IPR000623 Shikimate kinase/Threonine synthase-like 1 KEGG: 00400+2.7.1.71|MetaCyc: PWY-6163 TOPB45_1501 e21437bf14616bfe05e34fc9ae8bc5c1 176 Pfam PF01202 Shikimate kinase 11 170 3.5E-45 T 13-10-2018 IPR031322 Shikimate kinase/gluconokinase KEGG: 00400+2.7.1.71|MetaCyc: PWY-6163 TOPB45_1404 41cbcc722efbe1fe9924f7d128df982a 311 Gene3D G3DSA:3.90.1200.10 93 311 6.7E-38 T 13-10-2018 TOPB45_1404 41cbcc722efbe1fe9924f7d128df982a 311 Gene3D G3DSA:3.30.200.20 1 89 6.5E-11 T 13-10-2018 TOPB45_1404 41cbcc722efbe1fe9924f7d128df982a 311 SUPERFAMILY SSF56112 8 281 5.78E-33 T 13-10-2018 IPR011009 Protein kinase-like domain superfamily TOPB45_1404 41cbcc722efbe1fe9924f7d128df982a 311 Pfam PF01636 Phosphotransferase enzyme family 18 244 1.2E-14 T 13-10-2018 IPR002575 Aminoglycoside phosphotransferase TOPB45_0077 6a1c4bc39f75a7e36265a04b9c96e890 189 Gene3D G3DSA:3.40.50.1470 1 185 1.1E-63 T 13-10-2018 IPR036416 Peptidyl-tRNA hydrolase superfamily GO:0004045 MetaCyc: PWY-6308 TOPB45_0077 6a1c4bc39f75a7e36265a04b9c96e890 189 SUPERFAMILY SSF53178 1 184 1.96E-57 T 13-10-2018 IPR036416 Peptidyl-tRNA hydrolase superfamily GO:0004045 MetaCyc: PWY-6308 TOPB45_0077 6a1c4bc39f75a7e36265a04b9c96e890 189 Hamap MF_00083 Peptidyl-tRNA hydrolase [pth]. 1 175 32.535 T 13-10-2018 IPR001328 Peptidyl-tRNA hydrolase GO:0004045 MetaCyc: PWY-6308 TOPB45_0077 6a1c4bc39f75a7e36265a04b9c96e890 189 ProSitePatterns PS01195 Peptidyl-tRNA hydrolase signature 1. 14 27 - T 13-10-2018 IPR018171 Peptidyl-tRNA hydrolase, conserved site GO:0004045 MetaCyc: PWY-6308 TOPB45_0077 6a1c4bc39f75a7e36265a04b9c96e890 189 TIGRFAM TIGR00447 pth: aminoacyl-tRNA hydrolase 3 183 1.8E-53 T 13-10-2018 IPR001328 Peptidyl-tRNA hydrolase GO:0004045 MetaCyc: PWY-6308 TOPB45_0077 6a1c4bc39f75a7e36265a04b9c96e890 189 Pfam PF01195 Peptidyl-tRNA hydrolase 3 182 4.2E-54 T 13-10-2018 IPR001328 Peptidyl-tRNA hydrolase GO:0004045 MetaCyc: PWY-6308 TOPB45_1466 cf643cb6f9c1dae6dfa1dad09257c155 157 Gene3D G3DSA:3.40.1550.10 3 154 2.2E-28 T 13-10-2018 IPR028976 CheC-like superfamily TOPB45_1466 cf643cb6f9c1dae6dfa1dad09257c155 157 SUPERFAMILY SSF103039 6 145 6.93E-20 T 13-10-2018 IPR028976 CheC-like superfamily TOPB45_1466 cf643cb6f9c1dae6dfa1dad09257c155 157 Pfam PF13690 Chemotaxis phosphatase CheX 43 139 2.1E-18 T 13-10-2018 IPR028051 Chemotaxis phosphatase CheX-like domain TOPB45_0780 e2dd70b884b130667c146a22e1101cb4 210 Hamap MF_01306_B 30S ribosomal protein S4 [rpsD]. 1 210 37.158 T 13-10-2018 IPR005709 Ribosomal protein S4, bacterial-type GO:0003735|GO:0006412|GO:0015935 TOPB45_0780 e2dd70b884b130667c146a22e1101cb4 210 Pfam PF01479 S4 domain 100 147 4.5E-20 T 13-10-2018 IPR002942 RNA-binding S4 domain GO:0003723 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0780 e2dd70b884b130667c146a22e1101cb4 210 Gene3D G3DSA:3.10.290.10 99 195 3.5E-91 T 13-10-2018 IPR036986 RNA-binding S4 domain superfamily GO:0003723 TOPB45_0780 e2dd70b884b130667c146a22e1101cb4 210 TIGRFAM TIGR01017 rpsD_bact: ribosomal protein uS4 3 210 4.7E-79 T 13-10-2018 IPR005709 Ribosomal protein S4, bacterial-type GO:0003735|GO:0006412|GO:0015935 TOPB45_0780 e2dd70b884b130667c146a22e1101cb4 210 SUPERFAMILY SSF55174 2 210 3.27E-74 T 13-10-2018 TOPB45_0780 e2dd70b884b130667c146a22e1101cb4 210 Pfam PF00163 Ribosomal protein S4/S9 N-terminal domain 3 99 2.9E-35 T 13-10-2018 IPR001912 Ribosomal protein S4/S9, N-terminal GO:0005622|GO:0019843 Reactome: R-HSA-6790901|Reactome: R-HSA-6791226 TOPB45_0780 e2dd70b884b130667c146a22e1101cb4 210 SMART SM00363 100 164 6.3E-20 T 13-10-2018 IPR002942 RNA-binding S4 domain GO:0003723 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0780 e2dd70b884b130667c146a22e1101cb4 210 SMART SM01390 3 99 1.2E-56 T 13-10-2018 IPR001912 Ribosomal protein S4/S9, N-terminal GO:0005622|GO:0019843 Reactome: R-HSA-6790901|Reactome: R-HSA-6791226 TOPB45_0780 e2dd70b884b130667c146a22e1101cb4 210 Gene3D G3DSA:1.10.1050.10 6 210 3.5E-91 T 13-10-2018 TOPB45_0189 b0f3926b955c0ed2ec4afb55726b3c85 84 ProDom PD002239 RIBOSOMAL S18 RIBONUCLEOPROTEIN 30S RRNA-BINDING RNA-BINDING CHLOROPLAST PLASTID MITOCHONDRIAL ACETYLATION 28 80 2.0E-13 T 13-10-2018 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0189 b0f3926b955c0ed2ec4afb55726b3c85 84 SUPERFAMILY SSF46911 8 80 3.14E-28 T 13-10-2018 IPR036870 Ribosomal protein S18 superfamily Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0189 b0f3926b955c0ed2ec4afb55726b3c85 84 PRINTS PR00974 Ribosomal protein S18 family signature 67 77 9.1E-12 T 13-10-2018 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0189 b0f3926b955c0ed2ec4afb55726b3c85 84 PRINTS PR00974 Ribosomal protein S18 family signature 53 67 9.1E-12 T 13-10-2018 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0189 b0f3926b955c0ed2ec4afb55726b3c85 84 PRINTS PR00974 Ribosomal protein S18 family signature 35 45 9.1E-12 T 13-10-2018 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0189 b0f3926b955c0ed2ec4afb55726b3c85 84 Gene3D G3DSA:4.10.640.10 2 82 2.5E-28 T 13-10-2018 IPR036870 Ribosomal protein S18 superfamily Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0189 b0f3926b955c0ed2ec4afb55726b3c85 84 TIGRFAM TIGR00165 S18: ribosomal protein bS18 13 80 2.9E-26 T 13-10-2018 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0189 b0f3926b955c0ed2ec4afb55726b3c85 84 Hamap MF_00270 30S ribosomal protein S18 [rpsR]. 9 80 19.854 T 13-10-2018 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0189 b0f3926b955c0ed2ec4afb55726b3c85 84 Pfam PF01084 Ribosomal protein S18 25 75 2.2E-24 T 13-10-2018 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0461 f2719caa1396d3364300022ec86aae9a 259 Gene3D G3DSA:3.10.270.10 1 256 6.8E-103 T 13-10-2018 TOPB45_0461 f2719caa1396d3364300022ec86aae9a 259 Hamap MF_01527_B GTP cyclohydrolase FolE2 [folE2]. 3 257 38.239 T 13-10-2018 IPR022838 GTP cyclohydrolase FolE2 GO:0003934|GO:0035998 KEGG: 00790+3.5.4.16|MetaCyc: PWY-5663|MetaCyc: PWY-5664|MetaCyc: PWY-6147|MetaCyc: PWY-6703|MetaCyc: PWY-6983|MetaCyc: PWY-7442|MetaCyc: PWY-7852 TOPB45_0461 f2719caa1396d3364300022ec86aae9a 259 Pfam PF02649 Type I GTP cyclohydrolase folE2 3 252 1.8E-100 T 13-10-2018 IPR003801 GTP cyclohydrolase FolE2/MptA GO:0003933 KEGG: 00790+3.5.4.16|MetaCyc: PWY-5663|MetaCyc: PWY-5664|MetaCyc: PWY-6147|MetaCyc: PWY-6703|MetaCyc: PWY-6983|MetaCyc: PWY-7442|MetaCyc: PWY-7852 TOPB45_0461 f2719caa1396d3364300022ec86aae9a 259 TIGRFAM TIGR00294 TIGR00294: GTP cyclohydrolase 108 252 5.4E-35 T 13-10-2018 IPR003801 GTP cyclohydrolase FolE2/MptA GO:0003933 KEGG: 00790+3.5.4.16|MetaCyc: PWY-5663|MetaCyc: PWY-5664|MetaCyc: PWY-6147|MetaCyc: PWY-6703|MetaCyc: PWY-6983|MetaCyc: PWY-7442|MetaCyc: PWY-7852 TOPB45_0526 c91964d034628e3915120830bdda3d0b 311 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 89 299 6.6E-14 T 13-10-2018 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0016020|GO:0055085 TOPB45_0526 c91964d034628e3915120830bdda3d0b 311 SUPERFAMILY SSF161098 24 298 1.2E-31 T 13-10-2018 IPR035906 MetI-like superfamily TOPB45_0526 c91964d034628e3915120830bdda3d0b 311 TIGRFAM TIGR02138 phosphate_pstC: phosphate ABC transporter, permease protein PstC 13 305 7.8E-88 T 13-10-2018 IPR011864 Phosphate ABC transporter, permease protein PstC GO:0005315|GO:0006817|GO:0016021 TOPB45_0526 c91964d034628e3915120830bdda3d0b 311 Gene3D G3DSA:1.10.3720.10 57 309 1.7E-29 T 13-10-2018 IPR035906 MetI-like superfamily TOPB45_1399 303dc7405789341e00226aa1b97bba98 165 SUPERFAMILY SSF55021 83 163 2.75E-28 T 13-10-2018 TOPB45_1399 303dc7405789341e00226aa1b97bba98 165 TIGRFAM TIGR00119 acolac_sm: acetolactate synthase, small subunit 4 161 1.1E-61 T 13-10-2018 IPR004789 Acetolactate synthase, small subunit GO:0003984|GO:0009082 KEGG: 00290+2.2.1.6|KEGG: 00650+2.2.1.6|KEGG: 00660+2.2.1.6|KEGG: 00770+2.2.1.6|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-5938|MetaCyc: PWY-5939|MetaCyc: PWY-6389|MetaCyc: PWY-7111 TOPB45_1399 303dc7405789341e00226aa1b97bba98 165 Pfam PF10369 Small subunit of acetolactate synthase 88 160 3.6E-31 T 13-10-2018 IPR019455 Acetolactate synthase, small subunit, C-terminal KEGG: 00290+2.2.1.6|KEGG: 00650+2.2.1.6|KEGG: 00660+2.2.1.6|KEGG: 00770+2.2.1.6|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-5938|MetaCyc: PWY-5939|MetaCyc: PWY-6389|MetaCyc: PWY-7111 TOPB45_1399 303dc7405789341e00226aa1b97bba98 165 SUPERFAMILY SSF55021 5 78 4.31E-21 T 13-10-2018 TOPB45_1399 303dc7405789341e00226aa1b97bba98 165 Gene3D G3DSA:3.30.70.260 2 82 3.4E-33 T 13-10-2018 TOPB45_1399 303dc7405789341e00226aa1b97bba98 165 Pfam PF13710 ACT domain 15 76 2.3E-13 T 13-10-2018 TOPB45_1399 303dc7405789341e00226aa1b97bba98 165 ProDom PD002844 SMALL SUBUNIT ACETOLACTATE SYNTHASE SYNTHASE TRANSFERASE ACID BIOSYNTHESIS III LYASE 5 79 4.0E-24 T 13-10-2018 TOPB45_1399 303dc7405789341e00226aa1b97bba98 165 Gene3D G3DSA:3.30.70.1150 87 165 9.8E-33 T 13-10-2018 IPR027271 Acetolactate synthase/Transcription factor NikR, C-terminal TOPB45_1571 7b99fa80e780373b1bad4a674d33f1fa 260 Pfam PF06429 Flagellar basal body rod FlgEFG protein C-terminal 180 258 2.2E-24 T 13-10-2018 IPR010930 Flagellar basal-body/hook protein, C-terminal domain TOPB45_1571 7b99fa80e780373b1bad4a674d33f1fa 260 TIGRFAM TIGR02488 flgG_G_neg: flagellar basal-body rod protein FlgG 4 258 1.5E-100 T 13-10-2018 IPR012834 Flagellar basal-body rod FlgG GO:0009426|GO:0071973 TOPB45_1571 7b99fa80e780373b1bad4a674d33f1fa 260 TIGRFAM TIGR03506 FlgEFG_subfam: flagellar hook-basal body protein 3 135 4.7E-48 T 13-10-2018 IPR020013 Flagellar hook-basal body protein, FlgE/F/G TOPB45_1571 7b99fa80e780373b1bad4a674d33f1fa 260 TIGRFAM TIGR03506 FlgEFG_subfam: flagellar hook-basal body protein 142 241 1.5E-33 T 13-10-2018 IPR020013 Flagellar hook-basal body protein, FlgE/F/G TOPB45_1571 7b99fa80e780373b1bad4a674d33f1fa 260 ProSitePatterns PS00588 Flagella basal body rod proteins signature. 11 31 - T 13-10-2018 IPR019776 Flagellar basal body rod protein, conserved site TOPB45_1571 7b99fa80e780373b1bad4a674d33f1fa 260 SUPERFAMILY SSF117143 93 220 8.24E-38 T 13-10-2018 IPR037925 Flagellar hook-basal body protein, FlgE/F/G-like TOPB45_1571 7b99fa80e780373b1bad4a674d33f1fa 260 Pfam PF00460 Flagella basal body rod protein 5 35 4.4E-12 T 13-10-2018 IPR001444 Flagellar basal body rod protein, N-terminal GO:0071973 TOPB45_1318 2a2bedeab1265b28cc962211f4156936 301 Gene3D G3DSA:2.10.230.10 97 159 2.9E-21 T 13-10-2018 TOPB45_1318 2a2bedeab1265b28cc962211f4156936 301 SUPERFAMILY SSF49493 66 214 2.88E-8 T 13-10-2018 IPR008971 HSP40/DnaJ peptide-binding GO:0006457|GO:0051082 TOPB45_1318 2a2bedeab1265b28cc962211f4156936 301 Pfam PF01556 DnaJ C terminal domain 73 278 7.7E-22 T 13-10-2018 IPR002939 Chaperone DnaJ, C-terminal TOPB45_1318 2a2bedeab1265b28cc962211f4156936 301 SUPERFAMILY SSF57938 90 161 8.76E-14 T 13-10-2018 IPR036410 Heat shock protein DnaJ, cysteine-rich domain superfamily TOPB45_1318 2a2bedeab1265b28cc962211f4156936 301 SUPERFAMILY SSF46565 9 52 7.33E-9 T 13-10-2018 IPR036869 Chaperone J-domain superfamily TOPB45_1318 2a2bedeab1265b28cc962211f4156936 301 Gene3D G3DSA:1.10.287.110 2 59 2.7E-9 T 13-10-2018 IPR036869 Chaperone J-domain superfamily TOPB45_1318 2a2bedeab1265b28cc962211f4156936 301 Pfam PF00684 DnaJ central domain 97 159 7.1E-10 T 13-10-2018 IPR001305 Heat shock protein DnaJ, cysteine-rich domain GO:0031072|GO:0051082 TOPB45_1318 2a2bedeab1265b28cc962211f4156936 301 Gene3D G3DSA:2.60.260.20 72 186 2.9E-21 T 13-10-2018 TOPB45_1318 2a2bedeab1265b28cc962211f4156936 301 SUPERFAMILY SSF49493 206 289 1.1E-9 T 13-10-2018 IPR008971 HSP40/DnaJ peptide-binding GO:0006457|GO:0051082 TOPB45_1318 2a2bedeab1265b28cc962211f4156936 301 Gene3D G3DSA:2.60.260.20 201 301 5.4E-15 T 13-10-2018 TOPB45_0556 7a21deab5aaf001d39f251236b614587 227 SUPERFAMILY SSF52833 10 226 3.24E-73 T 13-10-2018 IPR036249 Thioredoxin-like superfamily TOPB45_0556 7a21deab5aaf001d39f251236b614587 227 Pfam PF10417 C-terminal domain of 1-Cys peroxiredoxin 164 213 3.1E-19 T 13-10-2018 IPR019479 Peroxiredoxin, C-terminal GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15|Reactome: R-HSA-3299685 TOPB45_0556 7a21deab5aaf001d39f251236b614587 227 Pfam PF00578 AhpC/TSA family 13 143 4.7E-34 T 13-10-2018 IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant GO:0016209|GO:0016491|GO:0055114 KEGG: 00480+1.11.1.15|Reactome: R-HSA-3299685 TOPB45_0556 7a21deab5aaf001d39f251236b614587 227 Hamap MF_00401 Peroxiredoxin. 11 226 47.868 T 13-10-2018 IPR022915 Peroxiredoxin, TDXH subfamily GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 TOPB45_0556 7a21deab5aaf001d39f251236b614587 227 PIRSF PIRSF000239 6 226 8.8E-80 T 13-10-2018 IPR024706 Peroxiredoxin, AhpC-type KEGG: 00480+1.11.1.15|Reactome: R-HSA-3299685 TOPB45_0556 7a21deab5aaf001d39f251236b614587 227 Gene3D G3DSA:3.30.1020.20 153 227 4.3E-25 T 13-10-2018 TOPB45_0556 7a21deab5aaf001d39f251236b614587 227 Gene3D G3DSA:3.40.30.10 11 152 1.1E-50 T 13-10-2018 TOPB45_0860 9635ef10ba588dbd5c74e41bea79eda3 139 Gene3D G3DSA:3.10.129.10 3 136 1.2E-29 T 13-10-2018 TOPB45_0860 9635ef10ba588dbd5c74e41bea79eda3 139 TIGRFAM TIGR00369 unchar_dom_1: uncharacterized domain 1 31 131 2.7E-13 T 13-10-2018 IPR003736 Phenylacetic acid degradation-related domain Reactome: R-HSA-77289 TOPB45_0860 9635ef10ba588dbd5c74e41bea79eda3 139 SUPERFAMILY SSF54637 6 131 5.87E-30 T 13-10-2018 IPR029069 HotDog domain superfamily TOPB45_0860 9635ef10ba588dbd5c74e41bea79eda3 139 Pfam PF03061 Thioesterase superfamily 50 123 5.7E-12 T 13-10-2018 IPR006683 Thioesterase domain Reactome: R-HSA-77289 TOPB45_1635 627df56a3b22121efb245717f4d7b42f 319 TIGRFAM TIGR01727 oligo_HPY: oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain 231 317 1.8E-20 T 13-10-2018 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 TOPB45_1635 627df56a3b22121efb245717f4d7b42f 319 ProSitePatterns PS00211 ABC transporters family signature. 154 168 - T 13-10-2018 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TOPB45_1635 627df56a3b22121efb245717f4d7b42f 319 Pfam PF00005 ABC transporter 32 182 2.4E-33 T 13-10-2018 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TOPB45_1635 627df56a3b22121efb245717f4d7b42f 319 SUPERFAMILY SSF52540 6 251 2.48E-63 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1635 627df56a3b22121efb245717f4d7b42f 319 SMART SM00382 39 231 3.6E-10 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_1635 627df56a3b22121efb245717f4d7b42f 319 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 233 298 1.5E-12 T 13-10-2018 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 TOPB45_1635 627df56a3b22121efb245717f4d7b42f 319 Gene3D G3DSA:3.40.50.300 3 319 1.2E-83 T 13-10-2018 TOPB45_0656 3101ce14221e808928e80bd5522d4af2 774 TIGRFAM TIGR03936 sam_1_link_chp: radical SAM-linked protein 606 681 7.8E-23 T 13-10-2018 IPR018768 Domain of unknown function DUF2344 TOPB45_0656 3101ce14221e808928e80bd5522d4af2 774 Pfam PF04055 Radical SAM superfamily 240 406 3.5E-17 T 13-10-2018 IPR007197 Radical SAM GO:0003824|GO:0051536 TOPB45_0656 3101ce14221e808928e80bd5522d4af2 774 SUPERFAMILY SSF102114 211 572 3.92E-42 T 13-10-2018 TOPB45_0656 3101ce14221e808928e80bd5522d4af2 774 Gene3D G3DSA:3.80.30.20 233 466 1.3E-23 T 13-10-2018 IPR023404 Radical SAM, alpha/beta horseshoe TOPB45_0656 3101ce14221e808928e80bd5522d4af2 774 SMART SM00729 235 454 6.1E-29 T 13-10-2018 IPR006638 Elp3/MiaB/NifB GO:0003824|GO:0051536 TOPB45_0656 3101ce14221e808928e80bd5522d4af2 774 Pfam PF10105 Uncharacterized protein conserved in bacteria (DUF2344) 607 681 3.2E-19 T 13-10-2018 IPR018768 Domain of unknown function DUF2344 TOPB45_0204 b9f649290737e1157996b6efc3a66c8c 122 Hamap MF_00446 Aspartate 1-decarboxylase [panD]. 1 122 54.199 T 13-10-2018 IPR003190 Aspartate decarboxylase GO:0004068|GO:0006523 KEGG: 00410+4.1.1.11|KEGG: 00770+4.1.1.11|MetaCyc: PWY-5155 TOPB45_0204 b9f649290737e1157996b6efc3a66c8c 122 PIRSF PIRSF006246 1 121 2.8E-45 T 13-10-2018 IPR003190 Aspartate decarboxylase GO:0004068|GO:0006523 KEGG: 00410+4.1.1.11|KEGG: 00770+4.1.1.11|MetaCyc: PWY-5155 TOPB45_0204 b9f649290737e1157996b6efc3a66c8c 122 SUPERFAMILY SSF50692 1 114 9.94E-40 T 13-10-2018 IPR009010 Aspartate decarboxylase-like domain superfamily TOPB45_0204 b9f649290737e1157996b6efc3a66c8c 122 TIGRFAM TIGR00223 panD: aspartate 1-decarboxylase 1 115 2.4E-37 T 13-10-2018 IPR003190 Aspartate decarboxylase GO:0004068|GO:0006523 KEGG: 00410+4.1.1.11|KEGG: 00770+4.1.1.11|MetaCyc: PWY-5155 TOPB45_0204 b9f649290737e1157996b6efc3a66c8c 122 Gene3D G3DSA:2.40.40.20 1 120 4.9E-43 T 13-10-2018 TOPB45_0204 b9f649290737e1157996b6efc3a66c8c 122 Pfam PF02261 Aspartate decarboxylase 1 112 8.7E-43 T 13-10-2018 IPR003190 Aspartate decarboxylase GO:0004068|GO:0006523 KEGG: 00410+4.1.1.11|KEGG: 00770+4.1.1.11|MetaCyc: PWY-5155 TOPB45_0204 b9f649290737e1157996b6efc3a66c8c 122 ProDom PD009294 ASPARTATE 1-DECARBOXYLASE DECARBOXYLASE CHAIN LYASE ALPHA ALPHA- CONTAINS: PRECURSOR BETA 5 115 3.0E-26 T 13-10-2018 IPR003190 Aspartate decarboxylase GO:0004068|GO:0006523 KEGG: 00410+4.1.1.11|KEGG: 00770+4.1.1.11|MetaCyc: PWY-5155 TOPB45_0491 0bbbe921374086572b35ab2ac5763cd9 193 Pfam PF09335 SNARE associated Golgi protein 43 160 1.6E-25 T 13-10-2018 IPR032816 SNARE associated Golgi protein TOPB45_0177 2730bb582304e8dda6103adb385a806e 166 TIGRFAM TIGR02060 aprB: adenylylsulfate reductase, beta subunit 1 134 6.6E-64 T 13-10-2018 IPR011802 Adenylylsulphate reductase, beta subunit TOPB45_0177 2730bb582304e8dda6103adb385a806e 166 Pfam PF13187 4Fe-4S dicluster domain 9 62 1.9E-9 T 13-10-2018 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain TOPB45_0177 2730bb582304e8dda6103adb385a806e 166 SUPERFAMILY SSF54862 4 120 4.03E-24 T 13-10-2018 TOPB45_0177 2730bb582304e8dda6103adb385a806e 166 Gene3D G3DSA:3.30.720.40 68 145 1.5E-24 T 13-10-2018 IPR038465 APS reductase, beta subunit, C-terminal domain superfamily TOPB45_0177 2730bb582304e8dda6103adb385a806e 166 Pfam PF12139 Adenosine-5'-phosphosulfate reductase beta subunit 64 138 8.2E-26 T 13-10-2018 IPR022738 Adenylylsulphate reductase, beta subunit, C-terminal TOPB45_0177 2730bb582304e8dda6103adb385a806e 166 Gene3D G3DSA:3.30.70.20 2 67 4.5E-29 T 13-10-2018 TOPB45_0177 2730bb582304e8dda6103adb385a806e 166 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 47 58 - T 13-10-2018 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site TOPB45_0270 09f322c3beca5bfaee9db1c9a005753c 409 Gene3D G3DSA:2.30.40.10 29 401 8.7E-70 T 13-10-2018 IPR011059 Metal-dependent hydrolase, composite domain superfamily GO:0016810 TOPB45_0270 09f322c3beca5bfaee9db1c9a005753c 409 Gene3D G3DSA:3.20.20.140 69 366 8.7E-70 T 13-10-2018 TOPB45_0270 09f322c3beca5bfaee9db1c9a005753c 409 SUPERFAMILY SSF51556 67 363 2.28E-58 T 13-10-2018 IPR032466 Metal-dependent hydrolase TOPB45_0270 09f322c3beca5bfaee9db1c9a005753c 409 Pfam PF01979 Amidohydrolase family 64 383 1.0E-40 T 13-10-2018 IPR006680 Amidohydrolase-related GO:0016787 TOPB45_0270 09f322c3beca5bfaee9db1c9a005753c 409 SUPERFAMILY SSF51338 12 82 3.02E-10 T 13-10-2018 IPR011059 Metal-dependent hydrolase, composite domain superfamily GO:0016810 TOPB45_1460 f915fe8242bad432387b5741da56d488 327 TIGRFAM TIGR02197 heptose_epim: ADP-glyceromanno-heptose 6-epimerase 6 320 3.1E-125 T 13-10-2018 IPR011912 ADP-L-glycero-D-manno-heptose-6-epimerase GO:0005975|GO:0008712|GO:0050661 KEGG: 00540+5.1.3.20 TOPB45_1460 f915fe8242bad432387b5741da56d488 327 Hamap MF_01601 ADP-L-glycero-D-manno-heptose-6-epimerase [hldD]. 5 321 47.763 T 13-10-2018 IPR011912 ADP-L-glycero-D-manno-heptose-6-epimerase GO:0005975|GO:0008712|GO:0050661 KEGG: 00540+5.1.3.20 TOPB45_1460 f915fe8242bad432387b5741da56d488 327 Gene3D G3DSA:3.40.50.720 7 315 1.8E-125 T 13-10-2018 TOPB45_1460 f915fe8242bad432387b5741da56d488 327 SUPERFAMILY SSF51735 1 323 2.71E-59 T 13-10-2018 IPR036291 NAD(P)-binding domain superfamily TOPB45_1460 f915fe8242bad432387b5741da56d488 327 Gene3D G3DSA:3.90.25.10 172 302 1.8E-125 T 13-10-2018 TOPB45_1460 f915fe8242bad432387b5741da56d488 327 Pfam PF01370 NAD dependent epimerase/dehydratase family 6 247 9.2E-42 T 13-10-2018 IPR001509 NAD-dependent epimerase/dehydratase GO:0003824|GO:0050662 TOPB45_1309 7fd37e55d7b2eee00d61a43ee98e0c78 171 SUPERFAMILY SSF47240 1 160 2.57E-60 T 13-10-2018 IPR009078 Ferritin-like superfamily TOPB45_1309 7fd37e55d7b2eee00d61a43ee98e0c78 171 Gene3D G3DSA:1.20.1260.10 1 164 3.7E-55 T 13-10-2018 IPR012347 Ferritin-like TOPB45_1309 7fd37e55d7b2eee00d61a43ee98e0c78 171 Pfam PF00210 Ferritin-like domain 7 143 2.7E-45 T 13-10-2018 IPR008331 Ferritin/DPS protein domain GO:0006879|GO:0008199 TOPB45_0519 a6fb00ca1a7659c8539940ba9d8cb7d6 192 Pfam PF02677 Uncharacterized BCR, COG1636 2 173 6.7E-55 T 13-10-2018 IPR003828 Epoxyqueuosine reductase QueH MetaCyc: PWY-6700 TOPB45_0519 a6fb00ca1a7659c8539940ba9d8cb7d6 192 Hamap MF_02089 Epoxyqueuosine reductase QueH [queH]. 2 174 30.065 T 13-10-2018 IPR003828 Epoxyqueuosine reductase QueH MetaCyc: PWY-6700 TOPB45_0649 b19d6625763230d4439116bdf63e1b4c 529 Pfam PF02652 L-lactate permease 1 523 2.2E-43 T 13-10-2018 IPR003804 L-lactate permease GO:0005887|GO:0015129|GO:0015727 TOPB45_0476 ca162c8b4fff9c230191f7411f20c8ab 177 TIGRFAM TIGR01670 KdsC-phosphatas: 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family 14 166 3.1E-54 T 13-10-2018 IPR010023 KdsC family GO:0016788 KEGG: 00540+3.1.3.45|MetaCyc: PWY-1269|MetaCyc: PWY-7674 TOPB45_0476 ca162c8b4fff9c230191f7411f20c8ab 177 PIRSF PIRSF006118 1 176 2.5E-67 T 13-10-2018 IPR010023 KdsC family GO:0016788 KEGG: 00540+3.1.3.45|MetaCyc: PWY-1269|MetaCyc: PWY-7674 TOPB45_0476 ca162c8b4fff9c230191f7411f20c8ab 177 Pfam PF08282 haloacid dehalogenase-like hydrolase 85 150 9.9E-9 T 13-10-2018 TOPB45_0476 ca162c8b4fff9c230191f7411f20c8ab 177 Gene3D G3DSA:3.40.50.1000 8 175 8.7E-56 T 13-10-2018 IPR023214 HAD superfamily TOPB45_0476 ca162c8b4fff9c230191f7411f20c8ab 177 SUPERFAMILY SSF56784 10 173 3.25E-40 T 13-10-2018 IPR036412 HAD-like superfamily TOPB45_0476 ca162c8b4fff9c230191f7411f20c8ab 177 TIGRFAM TIGR01662 HAD-SF-IIIA: HAD hydrolase, family IIIA 15 127 1.0E-15 T 13-10-2018 IPR006549 HAD-superfamily hydrolase,subfamily IIIA Reactome: R-HSA-5649702 TOPB45_1520 4648c3c1f0cdde8001e12cfeadd02759 146 SUPERFAMILY SSF51283 2 143 8.24E-34 T 13-10-2018 IPR036157 dUTPase-like superfamily TOPB45_1520 4648c3c1f0cdde8001e12cfeadd02759 146 TIGRFAM TIGR00576 dut: dUTP diphosphatase 3 143 6.6E-31 T 13-10-2018 IPR008181 Deoxyuridine triphosphate nucleotidohydrolase GO:0004170|GO:0046080 KEGG: 00240+3.6.1.23|KEGG: 00983+3.6.1.23 TOPB45_1520 4648c3c1f0cdde8001e12cfeadd02759 146 Gene3D G3DSA:2.70.40.10 1 143 9.4E-40 T 13-10-2018 IPR036157 dUTPase-like superfamily TOPB45_1520 4648c3c1f0cdde8001e12cfeadd02759 146 Pfam PF00692 dUTPase 12 143 2.3E-24 T 13-10-2018 IPR029054 dUTPase-like TOPB45_0706 e08395a28b53792b3d9907e358005212 85 SUPERFAMILY SSF54565 3 79 2.49E-31 T 13-10-2018 IPR023803 Ribosomal protein S16 domain superfamily Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0706 e08395a28b53792b3d9907e358005212 85 Gene3D G3DSA:3.30.1320.10 1 85 2.5E-33 T 13-10-2018 IPR023803 Ribosomal protein S16 domain superfamily Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0706 e08395a28b53792b3d9907e358005212 85 TIGRFAM TIGR00002 S16: ribosomal protein bS16 3 79 8.5E-33 T 13-10-2018 IPR000307 Ribosomal protein S16 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0706 e08395a28b53792b3d9907e358005212 85 Hamap MF_00385 30S ribosomal protein S16 [rpsP]. 2 77 24.624 T 13-10-2018 IPR000307 Ribosomal protein S16 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0706 e08395a28b53792b3d9907e358005212 85 Pfam PF00886 Ribosomal protein S16 9 67 2.8E-24 T 13-10-2018 IPR000307 Ribosomal protein S16 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0727 7ae32dd3615b71acd7ddf3e0e4458a25 762 Pfam PF00593 TonB dependent receptor 269 761 1.1E-29 T 13-10-2018 IPR000531 TonB-dependent receptor-like, beta-barrel TOPB45_0727 7ae32dd3615b71acd7ddf3e0e4458a25 762 Pfam PF07715 TonB-dependent Receptor Plug Domain 77 165 9.8E-9 T 13-10-2018 IPR012910 TonB-dependent receptor, plug domain TOPB45_0727 7ae32dd3615b71acd7ddf3e0e4458a25 762 Gene3D G3DSA:2.40.170.20 182 762 2.2E-60 T 13-10-2018 IPR036942 TonB-dependent receptor-like, beta-barrel domain superfamily TOPB45_0727 7ae32dd3615b71acd7ddf3e0e4458a25 762 Gene3D G3DSA:2.170.130.10 31 174 2.3E-9 T 13-10-2018 IPR037066 TonB-dependent receptor, plug domain superfamily TOPB45_0727 7ae32dd3615b71acd7ddf3e0e4458a25 762 SUPERFAMILY SSF56935 37 762 5.86E-80 T 13-10-2018 TOPB45_1467 7e7b1af7ea52223ed456eb391d1d68bd 540 PRINTS PR00260 Bacterial chemotaxis sensory transducer signature 299 328 6.4E-25 T 13-10-2018 IPR004090 Chemotaxis methyl-accepting receptor GO:0004888|GO:0006935|GO:0007165|GO:0016020 TOPB45_1467 7e7b1af7ea52223ed456eb391d1d68bd 540 PRINTS PR00260 Bacterial chemotaxis sensory transducer signature 453 482 6.4E-25 T 13-10-2018 IPR004090 Chemotaxis methyl-accepting receptor GO:0004888|GO:0006935|GO:0007165|GO:0016020 TOPB45_1467 7e7b1af7ea52223ed456eb391d1d68bd 540 PRINTS PR00260 Bacterial chemotaxis sensory transducer signature 376 403 6.4E-25 T 13-10-2018 IPR004090 Chemotaxis methyl-accepting receptor GO:0004888|GO:0006935|GO:0007165|GO:0016020 TOPB45_1467 7e7b1af7ea52223ed456eb391d1d68bd 540 PRINTS PR00260 Bacterial chemotaxis sensory transducer signature 405 434 6.4E-25 T 13-10-2018 IPR004090 Chemotaxis methyl-accepting receptor GO:0004888|GO:0006935|GO:0007165|GO:0016020 TOPB45_1467 7e7b1af7ea52223ed456eb391d1d68bd 540 Pfam PF00015 Methyl-accepting chemotaxis protein (MCP) signalling domain 347 505 3.7E-39 T 13-10-2018 IPR004089 Methyl-accepting chemotaxis protein (MCP) signalling domain GO:0007165|GO:0016020 TOPB45_1467 7e7b1af7ea52223ed456eb391d1d68bd 540 ProDom PD936484 POLYPROTEIN GLYCOPROTEIN M G2 TRANSMEMBRANE NONSTRUCTURAL MEMBRANE CONTAINS: PRECURSOR SIGNAL 50 535 1.0E-4 T 13-10-2018 TOPB45_1467 7e7b1af7ea52223ed456eb391d1d68bd 540 SMART SM00304 211 263 3.4E-7 T 13-10-2018 IPR003660 HAMP domain GO:0007165|GO:0016021 TOPB45_1467 7e7b1af7ea52223ed456eb391d1d68bd 540 Pfam PF00672 HAMP domain 212 251 1.3E-6 T 13-10-2018 IPR003660 HAMP domain GO:0007165|GO:0016021 TOPB45_1467 7e7b1af7ea52223ed456eb391d1d68bd 540 Gene3D G3DSA:1.10.287.950 210 540 9.4E-72 T 13-10-2018 TOPB45_1467 7e7b1af7ea52223ed456eb391d1d68bd 540 Pfam PF12729 Four helix bundle sensory module for signal transduction 4 176 2.2E-19 T 13-10-2018 IPR024478 Chemotaxis methyl-accepting receptor HlyB-like, 4HB MCP domain TOPB45_1467 7e7b1af7ea52223ed456eb391d1d68bd 540 SUPERFAMILY SSF58104 231 540 1.7E-68 T 13-10-2018 TOPB45_1467 7e7b1af7ea52223ed456eb391d1d68bd 540 SMART SM00283 278 539 1.5E-64 T 13-10-2018 IPR004089 Methyl-accepting chemotaxis protein (MCP) signalling domain GO:0007165|GO:0016020 TOPB45_0059 3816ed7764974ce0c6e15aaf4bcbe7d0 97 PRINTS PR01006 Flagellar hook-basal body complex protein FliE signature 27 43 1.3E-8 T 13-10-2018 IPR001624 Flagellar hook-basal body complex protein FliE GO:0003774|GO:0005198|GO:0009288|GO:0071973 TOPB45_0059 3816ed7764974ce0c6e15aaf4bcbe7d0 97 PRINTS PR01006 Flagellar hook-basal body complex protein FliE signature 82 95 1.3E-8 T 13-10-2018 IPR001624 Flagellar hook-basal body complex protein FliE GO:0003774|GO:0005198|GO:0009288|GO:0071973 TOPB45_0059 3816ed7764974ce0c6e15aaf4bcbe7d0 97 PRINTS PR01006 Flagellar hook-basal body complex protein FliE signature 61 77 1.3E-8 T 13-10-2018 IPR001624 Flagellar hook-basal body complex protein FliE GO:0003774|GO:0005198|GO:0009288|GO:0071973 TOPB45_0059 3816ed7764974ce0c6e15aaf4bcbe7d0 97 Pfam PF02049 Flagellar hook-basal body complex protein FliE 14 97 4.0E-24 T 13-10-2018 IPR001624 Flagellar hook-basal body complex protein FliE GO:0003774|GO:0005198|GO:0009288|GO:0071973 TOPB45_0059 3816ed7764974ce0c6e15aaf4bcbe7d0 97 TIGRFAM TIGR00205 fliE: flagellar hook-basal body complex protein FliE 13 97 3.8E-21 T 13-10-2018 IPR001624 Flagellar hook-basal body complex protein FliE GO:0003774|GO:0005198|GO:0009288|GO:0071973 TOPB45_0059 3816ed7764974ce0c6e15aaf4bcbe7d0 97 Hamap MF_00724 Flagellar hook-basal body complex protein FliE [fliE]. 1 97 15.629 T 13-10-2018 IPR001624 Flagellar hook-basal body complex protein FliE GO:0003774|GO:0005198|GO:0009288|GO:0071973 TOPB45_0022 dbc795232eacc702e5bd92d761166757 362 Gene3D G3DSA:1.10.150.530 3 63 2.7E-18 T 13-10-2018 TOPB45_0022 dbc795232eacc702e5bd92d761166757 362 SUPERFAMILY SSF102114 103 322 1.23E-16 T 13-10-2018 TOPB45_0022 dbc795232eacc702e5bd92d761166757 362 TIGRFAM TIGR00048 rRNA_mod_RlmN: 23S rRNA (adenine(2503)-C(2))-methyltransferase 2 346 5.1E-131 T 13-10-2018 IPR027492 Dual-specificity RNA methyltransferase RlmN GO:0030488|GO:0070475 TOPB45_0022 dbc795232eacc702e5bd92d761166757 362 Hamap MF_01849 Dual-specificity RNA methyltransferase RlmN [rlmN]. 3 346 69.253 T 13-10-2018 IPR027492 Dual-specificity RNA methyltransferase RlmN GO:0030488|GO:0070475 TOPB45_0022 dbc795232eacc702e5bd92d761166757 362 PIRSF PIRSF006004 2 358 7.3E-133 T 13-10-2018 IPR004383 Ribosomal RNA large subunit methyltransferase RlmN/Cfr GO:0005737|GO:0006364|GO:0008173 TOPB45_0022 dbc795232eacc702e5bd92d761166757 362 Pfam PF13394 4Fe-4S single cluster domain 111 205 1.5E-5 T 13-10-2018 TOPB45_0022 dbc795232eacc702e5bd92d761166757 362 SMART SM00729 102 314 0.0028 T 13-10-2018 IPR006638 Elp3/MiaB/NifB GO:0003824|GO:0051536 TOPB45_0022 dbc795232eacc702e5bd92d761166757 362 Pfam PF04055 Radical SAM superfamily 106 270 7.2E-15 T 13-10-2018 IPR007197 Radical SAM GO:0003824|GO:0051536 TOPB45_0022 dbc795232eacc702e5bd92d761166757 362 Gene3D G3DSA:3.20.20.70 65 330 4.2E-106 T 13-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 TOPB45_0416 856c71bc2fb8e2cf9b7b970bbd40c9ef 310 SMART SM00962 108 309 9.0E-111 T 13-10-2018 IPR000897 Signal recognition particle, SRP54 subunit, GTPase domain GO:0005525|GO:0006614 Reactome: R-HSA-1799339 TOPB45_0416 856c71bc2fb8e2cf9b7b970bbd40c9ef 310 Pfam PF02881 SRP54-type protein, helical bundle domain 25 91 1.8E-7 T 13-10-2018 IPR013822 Signal recognition particle, SRP54 subunit, helical bundle GO:0005525|GO:0006614 Reactome: R-HSA-1799339 TOPB45_0416 856c71bc2fb8e2cf9b7b970bbd40c9ef 310 TIGRFAM TIGR00064 ftsY: signal recognition particle-docking protein FtsY 42 307 1.7E-99 T 13-10-2018 IPR004390 Signal-recognition particle receptor FtsY GO:0006614 TOPB45_0416 856c71bc2fb8e2cf9b7b970bbd40c9ef 310 SMART SM00963 14 95 3.0E-9 T 13-10-2018 IPR013822 Signal recognition particle, SRP54 subunit, helical bundle GO:0005525|GO:0006614 Reactome: R-HSA-1799339 TOPB45_0416 856c71bc2fb8e2cf9b7b970bbd40c9ef 310 Hamap MF_00920 Signal recognition particle receptor FtsY [ftsY]. 38 309 56.661 T 13-10-2018 IPR004390 Signal-recognition particle receptor FtsY GO:0006614 TOPB45_0416 856c71bc2fb8e2cf9b7b970bbd40c9ef 310 Gene3D G3DSA:3.40.50.300 108 297 2.7E-103 T 13-10-2018 TOPB45_0416 856c71bc2fb8e2cf9b7b970bbd40c9ef 310 Gene3D G3DSA:1.20.120.140 12 307 2.7E-103 T 13-10-2018 TOPB45_0416 856c71bc2fb8e2cf9b7b970bbd40c9ef 310 SMART SM00382 107 264 3.8E-9 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_0416 856c71bc2fb8e2cf9b7b970bbd40c9ef 310 SUPERFAMILY SSF52540 104 308 2.03E-51 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0416 856c71bc2fb8e2cf9b7b970bbd40c9ef 310 ProSitePatterns PS00300 SRP54-type proteins GTP-binding domain signature. 282 295 - T 13-10-2018 IPR000897 Signal recognition particle, SRP54 subunit, GTPase domain GO:0005525|GO:0006614 Reactome: R-HSA-1799339 TOPB45_0416 856c71bc2fb8e2cf9b7b970bbd40c9ef 310 Pfam PF00448 SRP54-type protein, GTPase domain 108 308 3.8E-76 T 13-10-2018 IPR000897 Signal recognition particle, SRP54 subunit, GTPase domain GO:0005525|GO:0006614 Reactome: R-HSA-1799339 TOPB45_0416 856c71bc2fb8e2cf9b7b970bbd40c9ef 310 SUPERFAMILY SSF47364 9 89 6.54E-16 T 13-10-2018 IPR036225 SRP/SRP receptor, N-terminal Reactome: R-HSA-1799339 TOPB45_1519 71ff54cc810d884fe943f65bf07b90bc 209 Gene3D G3DSA:1.10.10.10 5 76 2.8E-25 T 13-10-2018 IPR036388 Winged helix-like DNA-binding domain superfamily TOPB45_1519 71ff54cc810d884fe943f65bf07b90bc 209 Hamap MF_01131 Redox-sensing transcriptional repressor Rex [rex]. 1 209 25.264 T 13-10-2018 IPR022876 Redox-sensing transcriptional repressor Rex GO:0005737|GO:0045892|GO:0051775 TOPB45_1519 71ff54cc810d884fe943f65bf07b90bc 209 SUPERFAMILY SSF46785 7 79 4.17E-16 T 13-10-2018 IPR036390 Winged helix DNA-binding domain superfamily TOPB45_1519 71ff54cc810d884fe943f65bf07b90bc 209 Pfam PF02629 CoA binding domain 82 177 7.4E-7 T 13-10-2018 IPR003781 CoA-binding GO:0048037 TOPB45_1519 71ff54cc810d884fe943f65bf07b90bc 209 SUPERFAMILY SSF51735 84 205 7.48E-5 T 13-10-2018 IPR036291 NAD(P)-binding domain superfamily TOPB45_1519 71ff54cc810d884fe943f65bf07b90bc 209 Pfam PF06971 Putative DNA-binding protein N-terminus 7 53 2.9E-18 T 13-10-2018 IPR009718 Rex DNA-binding, C-terminal domain GO:0005737|GO:0045892|GO:0051775 TOPB45_1519 71ff54cc810d884fe943f65bf07b90bc 209 Gene3D G3DSA:3.40.50.720 81 209 3.9E-23 T 13-10-2018 TOPB45_0138 9d1ea101fad4cdf1617fde08f2bfa1a7 395 Gene3D G3DSA:3.90.1150.10 11 382 5.9E-146 T 13-10-2018 IPR015422 Pyridoxal phosphate-dependent transferase domain 1 GO:0003824 TOPB45_0138 9d1ea101fad4cdf1617fde08f2bfa1a7 395 SUPERFAMILY SSF53383 12 392 4.17E-128 T 13-10-2018 IPR015424 Pyridoxal phosphate-dependent transferase TOPB45_0138 9d1ea101fad4cdf1617fde08f2bfa1a7 395 TIGRFAM TIGR00707 argD: transaminase, acetylornithine/succinylornithine family 14 392 1.4E-149 T 13-10-2018 IPR004636 Acetylornithine/Succinylornithine transaminase family GO:0006525|GO:0008483 TOPB45_0138 9d1ea101fad4cdf1617fde08f2bfa1a7 395 ProSitePatterns PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 218 255 - T 13-10-2018 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 TOPB45_0138 9d1ea101fad4cdf1617fde08f2bfa1a7 395 Hamap MF_01107 Acetylornithine/succinyldiaminopimelate aminotransferase [argD]. 11 395 68.067 T 13-10-2018 IPR004636 Acetylornithine/Succinylornithine transaminase family GO:0006525|GO:0008483 TOPB45_0138 9d1ea101fad4cdf1617fde08f2bfa1a7 395 Pfam PF00202 Aminotransferase class-III 20 392 1.6E-126 T 13-10-2018 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 TOPB45_0138 9d1ea101fad4cdf1617fde08f2bfa1a7 395 Gene3D G3DSA:3.40.640.10 55 302 5.9E-146 T 13-10-2018 IPR015421 Pyridoxal phosphate-dependent transferase, major domain GO:0003824 TOPB45_0138 9d1ea101fad4cdf1617fde08f2bfa1a7 395 PIRSF PIRSF000521 169 395 1.3E-41 T 13-10-2018 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 TOPB45_0138 9d1ea101fad4cdf1617fde08f2bfa1a7 395 PIRSF PIRSF000521 16 152 2.3E-6 T 13-10-2018 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 TOPB45_0672 d6e9c514ff88af62346517b7bdfb6971 360 Pfam PF01855 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg 17 225 3.4E-51 T 13-10-2018 IPR002880 Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal GO:0016491|GO:0055114 TOPB45_0672 d6e9c514ff88af62346517b7bdfb6971 360 Pfam PF17147 Pyruvate:ferredoxin oxidoreductase core domain II 249 328 9.0E-18 T 13-10-2018 IPR033412 Pyruvate:ferredoxin oxidoreductase, core domain II TOPB45_0672 d6e9c514ff88af62346517b7bdfb6971 360 SUPERFAMILY SSF52922 239 351 7.72E-17 T 13-10-2018 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824 TOPB45_0672 d6e9c514ff88af62346517b7bdfb6971 360 Gene3D G3DSA:3.40.50.920 237 353 3.2E-16 T 13-10-2018 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824 TOPB45_0672 d6e9c514ff88af62346517b7bdfb6971 360 Gene3D G3DSA:3.40.50.970 1 190 5.8E-64 T 13-10-2018 TOPB45_0672 d6e9c514ff88af62346517b7bdfb6971 360 SUPERFAMILY SSF52518 4 197 3.2E-57 T 13-10-2018 IPR029061 Thiamin diphosphate-binding fold TOPB45_0528 fffab4e024a3ac182acbcc3884bd119f 252 ProSitePatterns PS00211 ABC transporters family signature. 149 163 - T 13-10-2018 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 TOPB45_0528 fffab4e024a3ac182acbcc3884bd119f 252 SMART SM00382 31 232 3.5E-13 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_0528 fffab4e024a3ac182acbcc3884bd119f 252 Gene3D G3DSA:3.40.50.300 1 248 8.2E-72 T 13-10-2018 TOPB45_0528 fffab4e024a3ac182acbcc3884bd119f 252 SUPERFAMILY SSF52540 6 238 2.24E-64 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0528 fffab4e024a3ac182acbcc3884bd119f 252 Pfam PF00005 ABC transporter 22 177 9.7E-34 T 13-10-2018 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TOPB45_0528 fffab4e024a3ac182acbcc3884bd119f 252 TIGRFAM TIGR00972 3a0107s01c2: phosphate ABC transporter, ATP-binding protein 7 252 7.5E-123 T 13-10-2018 IPR005670 Phosphate transport system permease protein 1 GO:0005315|GO:0016020|GO:0035435 TOPB45_1081 b362f757fd7c2322dad89e6a6383364c 268 TIGRFAM TIGR04336 AmmeMemoSam_B: AmmeMemoRadiSam system protein B 3 267 6.7E-93 T 13-10-2018 TOPB45_1081 b362f757fd7c2322dad89e6a6383364c 268 Pfam PF01875 Memo-like protein 4 265 2.9E-74 T 13-10-2018 IPR002737 MEMO1 family Reactome: R-HSA-6785631 TOPB45_1081 b362f757fd7c2322dad89e6a6383364c 268 Hamap MF_00055 MEMO1 family protein . 1 268 55.9 T 13-10-2018 IPR002737 MEMO1 family Reactome: R-HSA-6785631 TOPB45_1081 b362f757fd7c2322dad89e6a6383364c 268 SUPERFAMILY SSF53213 56 189 3.66E-7 T 13-10-2018 TOPB45_1081 b362f757fd7c2322dad89e6a6383364c 268 Gene3D G3DSA:3.40.830.10 1 268 1.5E-64 T 13-10-2018 TOPB45_1631 a659b67e06c1125b4166e28e1bb565ad 135 Pfam PF03646 FlaG protein 53 131 5.9E-16 T 13-10-2018 IPR005186 FlaG protein TOPB45_1631 a659b67e06c1125b4166e28e1bb565ad 135 SUPERFAMILY SSF160214 53 116 1.22E-16 T 13-10-2018 IPR035924 FlaG-like superfamily TOPB45_1631 a659b67e06c1125b4166e28e1bb565ad 135 Gene3D G3DSA:3.30.160.170 24 118 4.2E-11 T 13-10-2018 IPR035924 FlaG-like superfamily TOPB45_1073 30fa9f9e9e7b378198c796b8dac274d8 204 TIGRFAM TIGR00427 TIGR00427: membrane protein, MarC family 4 200 7.4E-60 T 13-10-2018 IPR002771 Multiple antibiotic resistance (MarC)-related GO:0016021 TOPB45_1073 30fa9f9e9e7b378198c796b8dac274d8 204 Pfam PF01914 MarC family integral membrane protein 5 204 4.5E-62 T 13-10-2018 IPR002771 Multiple antibiotic resistance (MarC)-related GO:0016021 TOPB45_1181 00d6ae6ad5b21d29d481f89e4e66ca77 202 Pfam PF01966 HD domain 49 172 1.7E-20 T 13-10-2018 IPR006674 HD domain TOPB45_1181 00d6ae6ad5b21d29d481f89e4e66ca77 202 SUPERFAMILY SSF109604 37 194 9.71E-34 T 13-10-2018 TOPB45_1181 00d6ae6ad5b21d29d481f89e4e66ca77 202 Gene3D G3DSA:1.10.3210.10 4 201 3.4E-60 T 13-10-2018 TOPB45_1181 00d6ae6ad5b21d29d481f89e4e66ca77 202 SMART SM00471 43 181 2.5E-9 T 13-10-2018 IPR003607 HD/PDEase domain TOPB45_1440 93da4a58ed4576667a99fb53d6bf3a74 463 Gene3D G3DSA:2.30.250.10 104 244 3.0E-135 T 13-10-2018 IPR023358 Peptidase M18, domain 2 GO:0004177 TOPB45_1440 93da4a58ed4576667a99fb53d6bf3a74 463 SUPERFAMILY SSF53187 17 462 4.4E-84 T 13-10-2018 TOPB45_1440 93da4a58ed4576667a99fb53d6bf3a74 463 SUPERFAMILY SSF101821 105 240 3.11E-32 T 13-10-2018 TOPB45_1440 93da4a58ed4576667a99fb53d6bf3a74 463 Gene3D G3DSA:3.40.630.10 38 460 3.0E-135 T 13-10-2018 TOPB45_1440 93da4a58ed4576667a99fb53d6bf3a74 463 PRINTS PR00932 Aminopeptidase I zinc metalloprotease (M18) signature 428 443 2.9E-27 T 13-10-2018 IPR001948 Peptidase M18 GO:0004177|GO:0006508|GO:0008270 TOPB45_1440 93da4a58ed4576667a99fb53d6bf3a74 463 PRINTS PR00932 Aminopeptidase I zinc metalloprotease (M18) signature 162 179 2.9E-27 T 13-10-2018 IPR001948 Peptidase M18 GO:0004177|GO:0006508|GO:0008270 TOPB45_1440 93da4a58ed4576667a99fb53d6bf3a74 463 PRINTS PR00932 Aminopeptidase I zinc metalloprotease (M18) signature 334 350 2.9E-27 T 13-10-2018 IPR001948 Peptidase M18 GO:0004177|GO:0006508|GO:0008270 TOPB45_1440 93da4a58ed4576667a99fb53d6bf3a74 463 PRINTS PR00932 Aminopeptidase I zinc metalloprotease (M18) signature 289 307 2.9E-27 T 13-10-2018 IPR001948 Peptidase M18 GO:0004177|GO:0006508|GO:0008270 TOPB45_1440 93da4a58ed4576667a99fb53d6bf3a74 463 PRINTS PR00932 Aminopeptidase I zinc metalloprotease (M18) signature 93 109 2.9E-27 T 13-10-2018 IPR001948 Peptidase M18 GO:0004177|GO:0006508|GO:0008270 TOPB45_1440 93da4a58ed4576667a99fb53d6bf3a74 463 PRINTS PR00932 Aminopeptidase I zinc metalloprotease (M18) signature 126 146 2.9E-27 T 13-10-2018 IPR001948 Peptidase M18 GO:0004177|GO:0006508|GO:0008270 TOPB45_1440 93da4a58ed4576667a99fb53d6bf3a74 463 Pfam PF02127 Aminopeptidase I zinc metalloprotease (M18) 39 460 3.9E-88 T 13-10-2018 IPR001948 Peptidase M18 GO:0004177|GO:0006508|GO:0008270 TOPB45_0725 7893fc133956357debb24fd70ae49558 98 SUPERFAMILY SSF46565 12 84 7.72E-17 T 13-10-2018 IPR036869 Chaperone J-domain superfamily TOPB45_0725 7893fc133956357debb24fd70ae49558 98 SMART SM00271 11 65 3.9E-11 T 13-10-2018 IPR001623 DnaJ domain TOPB45_0725 7893fc133956357debb24fd70ae49558 98 Pfam PF00226 DnaJ domain 15 61 1.9E-11 T 13-10-2018 IPR001623 DnaJ domain TOPB45_0725 7893fc133956357debb24fd70ae49558 98 Gene3D G3DSA:1.10.287.110 4 63 7.2E-18 T 13-10-2018 IPR036869 Chaperone J-domain superfamily TOPB45_0634 5fbe71e2d11ae362e25e8e7580ed76a6 352 SUPERFAMILY SSF75138 208 322 7.98E-28 T 13-10-2018 IPR028979 HPr(Ser) kinase/phosphorylase-like, N-terminal domain superfamily TOPB45_0634 5fbe71e2d11ae362e25e8e7580ed76a6 352 SUPERFAMILY SSF52540 3 216 3.29E-14 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0634 5fbe71e2d11ae362e25e8e7580ed76a6 352 Gene3D G3DSA:3.40.1390.20 201 339 3.5E-41 T 13-10-2018 IPR028979 HPr(Ser) kinase/phosphorylase-like, N-terminal domain superfamily TOPB45_0634 5fbe71e2d11ae362e25e8e7580ed76a6 352 Pfam PF13500 AAA domain 4 205 8.9E-13 T 13-10-2018 TOPB45_0634 5fbe71e2d11ae362e25e8e7580ed76a6 352 Pfam PF07085 DRTGG domain 213 317 1.3E-24 T 13-10-2018 IPR010766 DRTGG KEGG: 00430+2.3.1.8|KEGG: 00620+2.3.1.8|KEGG: 00640+2.3.1.8|KEGG: 00680+2.3.1.8|KEGG: 00720+2.3.1.8|MetaCyc: PWY-1281|MetaCyc: PWY-5482|MetaCyc: PWY-5485|MetaCyc: PWY-5497|MetaCyc: PWY-6637 TOPB45_0662 a8b74599018091f745115179e222b706 427 Pfam PF00202 Aminotransferase class-III 31 396 5.0E-79 T 13-10-2018 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 TOPB45_0662 a8b74599018091f745115179e222b706 427 ProSitePatterns PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 235 271 - T 13-10-2018 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 TOPB45_0662 a8b74599018091f745115179e222b706 427 Gene3D G3DSA:3.40.640.10 70 318 2.3E-178 T 13-10-2018 IPR015421 Pyridoxal phosphate-dependent transferase, major domain GO:0003824 TOPB45_0662 a8b74599018091f745115179e222b706 427 Hamap MF_00375 Glutamate-1-semialdehyde 2,1-aminomutase [hemL]. 4 426 102.788 T 13-10-2018 IPR004639 Tetrapyrrole biosynthesis, glutamate-1-semialdehyde aminotransferase GO:0033014|GO:0042286 KEGG: 00860+5.4.3.8|MetaCyc: PWY-5188 TOPB45_0662 a8b74599018091f745115179e222b706 427 Gene3D G3DSA:3.90.1150.10 9 418 2.3E-178 T 13-10-2018 IPR015422 Pyridoxal phosphate-dependent transferase domain 1 GO:0003824 TOPB45_0662 a8b74599018091f745115179e222b706 427 SUPERFAMILY SSF53383 4 426 1.13E-131 T 13-10-2018 IPR015424 Pyridoxal phosphate-dependent transferase TOPB45_0662 a8b74599018091f745115179e222b706 427 TIGRFAM TIGR00713 hemL: glutamate-1-semialdehyde-2,1-aminomutase 4 425 1.2E-194 T 13-10-2018 IPR004639 Tetrapyrrole biosynthesis, glutamate-1-semialdehyde aminotransferase GO:0033014|GO:0042286 KEGG: 00860+5.4.3.8|MetaCyc: PWY-5188 TOPB45_0806 9c1140967ec19d1701417bb5245fb223 598 SUPERFAMILY SSF50156 230 305 1.55E-5 T 13-10-2018 IPR036034 PDZ superfamily GO:0005515 TOPB45_0806 9c1140967ec19d1701417bb5245fb223 598 Gene3D G3DSA:1.25.40.10 312 446 1.1E-8 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_0806 9c1140967ec19d1701417bb5245fb223 598 Gene3D G3DSA:2.30.42.10 217 311 7.5E-8 T 13-10-2018 TOPB45_0806 9c1140967ec19d1701417bb5245fb223 598 SUPERFAMILY SSF48452 321 425 4.83E-8 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_0487 d487b1c6483a363c11adba17f3a940dd 218 Gene3D G3DSA:3.20.20.70 1 216 6.7E-89 T 13-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 TOPB45_0487 d487b1c6483a363c11adba17f3a940dd 218 TIGRFAM TIGR00875 fsa_talC_mipB: fructose-6-phosphate aldolase 1 212 3.6E-91 T 13-10-2018 IPR004731 Transaldolase type 3B/Fructose-6-phosphate aldolase GO:0005975 KEGG: 00030+2.2.1.2|MetaCyc: PWY-1861|MetaCyc: PWY-5723 TOPB45_0487 d487b1c6483a363c11adba17f3a940dd 218 ProSitePatterns PS00958 Transaldolase active site. 81 98 - T 13-10-2018 IPR018225 Transaldolase, active site GO:0005975 KEGG: 00030+2.2.1.2|MetaCyc: PWY-1861|MetaCyc: PWY-5723|Reactome: R-HSA-163754|Reactome: R-HSA-6791055|Reactome: R-HSA-6791462|Reactome: R-HSA-71336|Reactome: R-HSA-8950505 TOPB45_0487 d487b1c6483a363c11adba17f3a940dd 218 ProSitePatterns PS01054 Transaldolase signature 1. 24 32 - T 13-10-2018 IPR018225 Transaldolase, active site GO:0005975 KEGG: 00030+2.2.1.2|MetaCyc: PWY-1861|MetaCyc: PWY-5723|Reactome: R-HSA-163754|Reactome: R-HSA-6791055|Reactome: R-HSA-6791462|Reactome: R-HSA-71336|Reactome: R-HSA-8950505 TOPB45_0487 d487b1c6483a363c11adba17f3a940dd 218 SUPERFAMILY SSF51569 1 213 3.56E-76 T 13-10-2018 TOPB45_0487 d487b1c6483a363c11adba17f3a940dd 218 Pfam PF00923 Transaldolase/Fructose-6-phosphate aldolase 3 203 9.4E-60 T 13-10-2018 IPR001585 Transaldolase/Fructose-6-phosphate aldolase GO:0005975 KEGG: 00030+2.2.1.2|MetaCyc: PWY-1861|MetaCyc: PWY-5723|Reactome: R-HSA-163754|Reactome: R-HSA-6791055|Reactome: R-HSA-6791462|Reactome: R-HSA-71336|Reactome: R-HSA-8950505 TOPB45_0487 d487b1c6483a363c11adba17f3a940dd 218 Hamap MF_00494 Probable transaldolase [tal]. 1 215 43.544 T 13-10-2018 IPR022999 Transaldolase type 3B, putative GO:0004801 KEGG: 00030+2.2.1.2|MetaCyc: PWY-1861|MetaCyc: PWY-5723 TOPB45_0337 58d31f5d43f8f9f3a3a180002c322d2f 240 Gene3D G3DSA:3.40.50.150 1 220 1.1E-45 T 13-10-2018 TOPB45_0337 58d31f5d43f8f9f3a3a180002c322d2f 240 SUPERFAMILY SSF53335 60 210 3.54E-15 T 13-10-2018 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TOPB45_0337 58d31f5d43f8f9f3a3a180002c322d2f 240 Pfam PF13578 Methyltransferase domain 76 189 1.8E-8 T 13-10-2018 TOPB45_0582 7ea1628662690119e6fd1eeeae270114 290 TIGRFAM TIGR00277 HDIG: HDIG domain 109 209 1.2E-10 T 13-10-2018 IPR006675 HDIG domain TOPB45_0582 7ea1628662690119e6fd1eeeae270114 290 SUPERFAMILY SSF109604 14 271 2.51E-66 T 13-10-2018 TOPB45_0582 7ea1628662690119e6fd1eeeae270114 290 Pfam PF08668 HDOD domain 22 209 3.3E-60 T 13-10-2018 IPR013976 Metal-dependent hydrolase HDOD TOPB45_0582 7ea1628662690119e6fd1eeeae270114 290 SMART SM00471 106 241 8.4E-7 T 13-10-2018 IPR003607 HD/PDEase domain TOPB45_0582 7ea1628662690119e6fd1eeeae270114 290 Gene3D G3DSA:1.10.3210.10 3 283 1.2E-77 T 13-10-2018 TOPB45_0019 59ef069b665b9afbfc9a4d489ec70148 388 Gene3D G3DSA:3.80.30.20 1 307 9.3E-91 T 13-10-2018 IPR023404 Radical SAM, alpha/beta horseshoe TOPB45_0019 59ef069b665b9afbfc9a4d489ec70148 388 Pfam PF06969 HemN C-terminal domain 315 371 3.5E-8 T 13-10-2018 IPR010723 HemN, C-terminal TOPB45_0019 59ef069b665b9afbfc9a4d489ec70148 388 Pfam PF04055 Radical SAM superfamily 11 182 2.7E-14 T 13-10-2018 IPR007197 Radical SAM GO:0003824|GO:0051536 TOPB45_0019 59ef069b665b9afbfc9a4d489ec70148 388 TIGRFAM TIGR00539 hemN_rel: putative oxygen-independent coproporphyrinogen III oxidase 8 360 1.1E-83 T 13-10-2018 IPR004559 Oxygen-independent coproporphyrinogen III oxidase-like GO:0004109|GO:0005737|GO:0006779|GO:0055114 TOPB45_0019 59ef069b665b9afbfc9a4d489ec70148 388 SUPERFAMILY SSF102114 6 383 3.79E-97 T 13-10-2018 TOPB45_0019 59ef069b665b9afbfc9a4d489ec70148 388 SMART SM00729 5 230 1.8E-40 T 13-10-2018 IPR006638 Elp3/MiaB/NifB GO:0003824|GO:0051536 TOPB45_0117 690dc1e32ed169eb693469f86c4caa8d 275 Hamap MF_00996 1,4-dihydroxy-6-naphtoate synthase [mqnD]. 5 269 33.675 T 13-10-2018 IPR030869 1,4-dihydroxy-6-naphtoate synthase GO:0009234|GO:0016829 TOPB45_0117 690dc1e32ed169eb693469f86c4caa8d 275 SUPERFAMILY SSF53850 6 260 1.81E-60 T 13-10-2018 TOPB45_0117 690dc1e32ed169eb693469f86c4caa8d 275 Gene3D G3DSA:3.40.190.10 8 258 9.7E-83 T 13-10-2018 TOPB45_0117 690dc1e32ed169eb693469f86c4caa8d 275 Pfam PF02621 Menaquinone biosynthesis 6 260 1.3E-59 T 13-10-2018 IPR003773 Menaquinone biosynthesis enzyme TOPB45_0117 690dc1e32ed169eb693469f86c4caa8d 275 Gene3D G3DSA:3.40.190.10 82 177 9.7E-83 T 13-10-2018 TOPB45_1373 88a5bb8326e86091ef18ffebdfa55454 298 SUPERFAMILY SSF46565 4 66 6.15E-9 T 13-10-2018 IPR036869 Chaperone J-domain superfamily TOPB45_1373 88a5bb8326e86091ef18ffebdfa55454 298 Gene3D G3DSA:1.10.287.110 1 71 8.2E-9 T 13-10-2018 IPR036869 Chaperone J-domain superfamily TOPB45_0041 308174ffba732f2a63b3c2f4675bad52 120 SUPERFAMILY SSF57716 80 116 3.65E-11 T 13-10-2018 TOPB45_0041 308174ffba732f2a63b3c2f4675bad52 120 ProSitePatterns PS01102 Prokaryotic dksA C4-type zinc finger. 83 107 - T 13-10-2018 IPR020458 Zinc finger, DksA/TraR C4-type conserved site TOPB45_0041 308174ffba732f2a63b3c2f4675bad52 120 Pfam PF01258 Prokaryotic dksA/traR C4-type zinc finger 78 113 1.3E-12 T 13-10-2018 IPR000962 Zinc finger, DksA/TraR C4-type GO:0008270 TOPB45_0041 308174ffba732f2a63b3c2f4675bad52 120 SUPERFAMILY SSF109635 1 79 9.94E-24 T 13-10-2018 IPR037187 DksA, N-terminal domain superfamily TOPB45_0041 308174ffba732f2a63b3c2f4675bad52 120 TIGRFAM TIGR02420 dksA: RNA polymerase-binding protein DksA 1 109 4.0E-39 T 13-10-2018 IPR012784 RNA polymerase-binding transcription factor DksA GO:0008270 TOPB45_0041 308174ffba732f2a63b3c2f4675bad52 120 Gene3D G3DSA:1.20.120.910 1 119 1.3E-38 T 13-10-2018 TOPB45_0884 cafffda58e09f7f4b72785cfa79fabc9 377 TIGRFAM TIGR00075 hypD: hydrogenase expression/formation protein HypD 12 374 5.7E-138 T 13-10-2018 IPR002780 Hydrogenase formation HypD protein GO:0046872 TOPB45_0884 cafffda58e09f7f4b72785cfa79fabc9 377 Gene3D G3DSA:3.40.50.11750 24 268 7.4E-104 T 13-10-2018 TOPB45_0884 cafffda58e09f7f4b72785cfa79fabc9 377 Gene3D G3DSA:1.10.10.2140 324 374 2.2E-24 T 13-10-2018 TOPB45_0884 cafffda58e09f7f4b72785cfa79fabc9 377 Gene3D G3DSA:3.40.50.11740 69 308 7.4E-104 T 13-10-2018 TOPB45_0884 cafffda58e09f7f4b72785cfa79fabc9 377 Pfam PF01924 Hydrogenase formation hypA family 20 372 3.6E-144 T 13-10-2018 IPR002780 Hydrogenase formation HypD protein GO:0046872 TOPB45_0884 cafffda58e09f7f4b72785cfa79fabc9 377 PIRSF PIRSF005622 8 377 5.2E-148 T 13-10-2018 IPR002780 Hydrogenase formation HypD protein GO:0046872 TOPB45_1598 eb95e18fb4e9d528db7ebca18637be72 185 TIGRFAM TIGR02175 PorC_KorC: 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family 1 180 4.1E-67 T 13-10-2018 IPR011894 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate GO:0016625|GO:0055114 TOPB45_1598 eb95e18fb4e9d528db7ebca18637be72 185 Gene3D G3DSA:3.40.920.10 1 182 3.9E-67 T 13-10-2018 IPR002869 Pyruvate-flavodoxin oxidoreductase, central domain GO:0016491|GO:0055114 TOPB45_1598 eb95e18fb4e9d528db7ebca18637be72 185 Pfam PF01558 Pyruvate ferredoxin/flavodoxin oxidoreductase 10 176 5.4E-38 T 13-10-2018 IPR019752 Pyruvate/ketoisovalerate oxidoreductase, catalytic domain GO:0016903|GO:0055114 TOPB45_1598 eb95e18fb4e9d528db7ebca18637be72 185 SUPERFAMILY SSF53323 1 179 4.84E-51 T 13-10-2018 IPR002869 Pyruvate-flavodoxin oxidoreductase, central domain GO:0016491|GO:0055114 TOPB45_0699 65dd0cab5ce6e224738e8280cfe56a29 383 Gene3D G3DSA:1.20.1250.20 3 195 4.7E-12 T 13-10-2018 TOPB45_0699 65dd0cab5ce6e224738e8280cfe56a29 383 Gene3D G3DSA:1.20.1250.20 206 381 9.1E-15 T 13-10-2018 TOPB45_0699 65dd0cab5ce6e224738e8280cfe56a29 383 SUPERFAMILY SSF103473 10 378 4.58E-35 T 13-10-2018 IPR036259 MFS transporter superfamily TOPB45_0699 65dd0cab5ce6e224738e8280cfe56a29 383 Pfam PF07690 Major Facilitator Superfamily 237 366 4.1E-9 T 13-10-2018 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TOPB45_0699 65dd0cab5ce6e224738e8280cfe56a29 383 Pfam PF07690 Major Facilitator Superfamily 37 221 1.6E-9 T 13-10-2018 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TOPB45_1629 d7f8bcbb41325b3fd4d503a9dab41481 129 TIGRFAM TIGR00208 fliS: flagellar protein FliS 4 122 3.3E-20 T 13-10-2018 IPR003713 Flagellar protein FliS GO:0044780 TOPB45_1629 d7f8bcbb41325b3fd4d503a9dab41481 129 Pfam PF02561 Flagellar protein FliS 4 121 2.3E-33 T 13-10-2018 IPR003713 Flagellar protein FliS GO:0044780 TOPB45_1629 d7f8bcbb41325b3fd4d503a9dab41481 129 SUPERFAMILY SSF101116 2 124 4.19E-30 T 13-10-2018 IPR036584 Flagellar protein FliS superfamily GO:0044780 TOPB45_1629 d7f8bcbb41325b3fd4d503a9dab41481 129 PIRSF PIRSF039090 1 128 5.8E-28 T 13-10-2018 IPR003713 Flagellar protein FliS GO:0044780 TOPB45_1629 d7f8bcbb41325b3fd4d503a9dab41481 129 Gene3D G3DSA:1.20.120.340 1 126 5.4E-37 T 13-10-2018 TOPB45_1586 c61873eb9abd24b33ed296f92b3c8aa4 645 Gene3D G3DSA:3.30.499.20 4 267 4.0E-87 T 13-10-2018 TOPB45_1586 c61873eb9abd24b33ed296f92b3c8aa4 645 SUPERFAMILY SSF53732 1 430 4.58E-144 T 13-10-2018 IPR036008 Aconitase, iron-sulfur domain KEGG: 00290+4.2.1.33 TOPB45_1586 c61873eb9abd24b33ed296f92b3c8aa4 645 Pfam PF00694 Aconitase C-terminal domain 505 581 5.1E-24 T 13-10-2018 IPR000573 Aconitase A/isopropylmalate dehydratase small subunit, swivel domain KEGG: 00290+4.2.1.33 TOPB45_1586 c61873eb9abd24b33ed296f92b3c8aa4 645 Gene3D G3DSA:3.20.19.10 455 645 1.8E-44 T 13-10-2018 IPR015928 Aconitase/3-isopropylmalate dehydratase, swivel KEGG: 00290+4.2.1.33 TOPB45_1586 c61873eb9abd24b33ed296f92b3c8aa4 645 SUPERFAMILY SSF52016 438 644 1.1E-51 T 13-10-2018 TOPB45_1586 c61873eb9abd24b33ed296f92b3c8aa4 645 Gene3D G3DSA:3.30.499.10 270 433 2.0E-42 T 13-10-2018 IPR015931 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 KEGG: 00290+4.2.1.33 TOPB45_1586 c61873eb9abd24b33ed296f92b3c8aa4 645 Pfam PF00330 Aconitase family (aconitate hydratase) 8 407 1.6E-103 T 13-10-2018 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain KEGG: 00290+4.2.1.33 TOPB45_1586 c61873eb9abd24b33ed296f92b3c8aa4 645 PRINTS PR00415 Aconitase family signature 90 98 4.9E-21 T 13-10-2018 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain KEGG: 00290+4.2.1.33 TOPB45_1586 c61873eb9abd24b33ed296f92b3c8aa4 645 PRINTS PR00415 Aconitase family signature 110 123 4.9E-21 T 13-10-2018 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain KEGG: 00290+4.2.1.33 TOPB45_1586 c61873eb9abd24b33ed296f92b3c8aa4 645 PRINTS PR00415 Aconitase family signature 186 199 4.9E-21 T 13-10-2018 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain KEGG: 00290+4.2.1.33 TOPB45_1586 c61873eb9abd24b33ed296f92b3c8aa4 645 PRINTS PR00415 Aconitase family signature 200 213 4.9E-21 T 13-10-2018 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain KEGG: 00290+4.2.1.33 TOPB45_1586 c61873eb9abd24b33ed296f92b3c8aa4 645 PRINTS PR00415 Aconitase family signature 349 362 4.9E-21 T 13-10-2018 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain KEGG: 00290+4.2.1.33 TOPB45_1586 c61873eb9abd24b33ed296f92b3c8aa4 645 PRINTS PR00415 Aconitase family signature 124 139 4.9E-21 T 13-10-2018 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain KEGG: 00290+4.2.1.33 TOPB45_1586 c61873eb9abd24b33ed296f92b3c8aa4 645 TIGRFAM TIGR01342 acon_putative: putative aconitate hydratase 4 644 8.4E-285 T 13-10-2018 IPR006250 Aconitase, putative TOPB45_0279 71d267fe3ac2a644bcd56929c481bce9 852 TIGRFAM TIGR02094 more_P_ylases: alpha-glucan phosphorylases 107 702 2.5E-202 T 13-10-2018 IPR011834 Alpha-glucan phosphorylase GO:0004645|GO:0005975|GO:0030170 KEGG: 00500+2.4.1.1|MetaCyc: PWY-5941|MetaCyc: PWY-6731|MetaCyc: PWY-6737|MetaCyc: PWY-7238 TOPB45_0279 71d267fe3ac2a644bcd56929c481bce9 852 Pfam PF00343 Carbohydrate phosphorylase 125 174 2.0E-4 T 13-10-2018 IPR000811 Glycosyl transferase, family 35 GO:0005975|GO:0008184 KEGG: 00500+2.4.1.1|MetaCyc: PWY-5941|MetaCyc: PWY-6731|MetaCyc: PWY-6737|MetaCyc: PWY-7238|Reactome: R-HSA-70221 TOPB45_0279 71d267fe3ac2a644bcd56929c481bce9 852 Pfam PF00343 Carbohydrate phosphorylase 272 617 4.1E-26 T 13-10-2018 IPR000811 Glycosyl transferase, family 35 GO:0005975|GO:0008184 KEGG: 00500+2.4.1.1|MetaCyc: PWY-5941|MetaCyc: PWY-6731|MetaCyc: PWY-6737|MetaCyc: PWY-7238|Reactome: R-HSA-70221 TOPB45_0279 71d267fe3ac2a644bcd56929c481bce9 852 PIRSF PIRSF000460 1 783 3.4E-212 T 13-10-2018 IPR000811 Glycosyl transferase, family 35 GO:0005975|GO:0008184 KEGG: 00500+2.4.1.1|MetaCyc: PWY-5941|MetaCyc: PWY-6731|MetaCyc: PWY-6737|MetaCyc: PWY-7238|Reactome: R-HSA-70221 TOPB45_0279 71d267fe3ac2a644bcd56929c481bce9 852 Gene3D G3DSA:3.40.50.2000 267 416 1.4E-13 T 13-10-2018 TOPB45_0279 71d267fe3ac2a644bcd56929c481bce9 852 SUPERFAMILY SSF53756 4 734 1.35E-166 T 13-10-2018 TOPB45_0279 71d267fe3ac2a644bcd56929c481bce9 852 Pfam PF11897 Protein of unknown function (DUF3417) 12 120 5.6E-24 T 13-10-2018 IPR024517 Glycogen phosphorylase, domain of unknown function DUF3417 KEGG: 00500+2.4.1.1|MetaCyc: PWY-5941|MetaCyc: PWY-6731|MetaCyc: PWY-6737|MetaCyc: PWY-7238 TOPB45_0279 71d267fe3ac2a644bcd56929c481bce9 852 Gene3D G3DSA:3.40.50.2000 116 210 1.2E-9 T 13-10-2018 TOPB45_0279 71d267fe3ac2a644bcd56929c481bce9 852 Gene3D G3DSA:3.40.50.2000 417 699 2.3E-38 T 13-10-2018 TOPB45_0510 e7d208c2d851eb96ae955f620a7f621c 370 SUPERFAMILY SSF53756 45 368 3.04E-63 T 13-10-2018 TOPB45_0510 e7d208c2d851eb96ae955f620a7f621c 370 Pfam PF00534 Glycosyl transferases group 1 177 348 2.0E-37 T 13-10-2018 IPR001296 Glycosyl transferase, family 1 TOPB45_0510 e7d208c2d851eb96ae955f620a7f621c 370 Gene3D G3DSA:3.40.50.2000 47 365 2.1E-56 T 13-10-2018 TOPB45_0510 e7d208c2d851eb96ae955f620a7f621c 370 Gene3D G3DSA:3.40.50.2000 166 353 2.1E-56 T 13-10-2018 TOPB45_1464 cc900ddb3f8d64aa8866e262bf096f07 373 Gene3D G3DSA:3.20.20.70 1 223 1.2E-73 T 13-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 TOPB45_1464 cc900ddb3f8d64aa8866e262bf096f07 373 Hamap MF_00042 Ribonuclease H [rnhA]. 227 372 29.103 T 13-10-2018 IPR022892 Ribonuclease HI GO:0004523 TOPB45_1464 cc900ddb3f8d64aa8866e262bf096f07 373 SMART SM01133 6 217 2.8E-56 T 13-10-2018 IPR002915 DeoC/FbaB/ lacD aldolase GO:0016829 Reactome: R-HSA-6798695|Reactome: R-HSA-71336 TOPB45_1464 cc900ddb3f8d64aa8866e262bf096f07 373 Pfam PF00075 RNase H 228 366 1.2E-42 T 13-10-2018 IPR002156 Ribonuclease H domain GO:0003676|GO:0004523 TOPB45_1464 cc900ddb3f8d64aa8866e262bf096f07 373 TIGRFAM TIGR00126 deoC: deoxyribose-phosphate aldolase 7 215 4.7E-58 T 13-10-2018 IPR011343 Deoxyribose-phosphate aldolase GO:0004139|GO:0005737|GO:0009264 KEGG: 00030+4.1.2.4|MetaCyc: PWY-7180|Reactome: R-HSA-6798695|Reactome: R-HSA-71336 TOPB45_1464 cc900ddb3f8d64aa8866e262bf096f07 373 Pfam PF01791 DeoC/LacD family aldolase 20 216 3.8E-13 T 13-10-2018 IPR002915 DeoC/FbaB/ lacD aldolase GO:0016829 Reactome: R-HSA-6798695|Reactome: R-HSA-71336 TOPB45_1464 cc900ddb3f8d64aa8866e262bf096f07 373 Hamap MF_00114 Deoxyribose-phosphate aldolase [deoC]. 5 219 27.759 T 13-10-2018 IPR028581 Deoxyribose-phosphate aldolase type I GO:0004139 KEGG: 00030+4.1.2.4|MetaCyc: PWY-7180 TOPB45_1464 cc900ddb3f8d64aa8866e262bf096f07 373 SUPERFAMILY SSF51569 4 218 1.26E-60 T 13-10-2018 TOPB45_1464 cc900ddb3f8d64aa8866e262bf096f07 373 SUPERFAMILY SSF53098 229 368 2.71E-50 T 13-10-2018 IPR012337 Ribonuclease H-like superfamily TOPB45_1464 cc900ddb3f8d64aa8866e262bf096f07 373 Gene3D G3DSA:3.30.420.10 224 372 9.2E-55 T 13-10-2018 IPR036397 Ribonuclease H superfamily GO:0003676 TOPB45_0752 e5649fb035b13232cce9506ba78f4974 103 Gene3D G3DSA:3.30.70.600 1 103 1.2E-41 T 13-10-2018 IPR036838 Ribosomal protein S10 domain superfamily TOPB45_0752 e5649fb035b13232cce9506ba78f4974 103 Pfam PF00338 Ribosomal protein S10p/S20e 8 102 7.4E-39 T 13-10-2018 IPR027486 Ribosomal protein S10 domain TOPB45_0752 e5649fb035b13232cce9506ba78f4974 103 Hamap MF_00508 30S ribosomal protein S10 [rpsJ]. 4 103 27.976 T 13-10-2018 IPR001848 Ribosomal protein S10 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0752 e5649fb035b13232cce9506ba78f4974 103 SMART SM01403 8 102 7.2E-59 T 13-10-2018 IPR027486 Ribosomal protein S10 domain TOPB45_0752 e5649fb035b13232cce9506ba78f4974 103 PRINTS PR00971 Ribosomal protein S10 family signature 6 19 1.1E-20 T 13-10-2018 IPR001848 Ribosomal protein S10 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0752 e5649fb035b13232cce9506ba78f4974 103 PRINTS PR00971 Ribosomal protein S10 family signature 41 56 1.1E-20 T 13-10-2018 IPR001848 Ribosomal protein S10 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0752 e5649fb035b13232cce9506ba78f4974 103 PRINTS PR00971 Ribosomal protein S10 family signature 62 76 1.1E-20 T 13-10-2018 IPR001848 Ribosomal protein S10 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0752 e5649fb035b13232cce9506ba78f4974 103 ProSitePatterns PS00361 Ribosomal protein S10 signature. 30 45 - T 13-10-2018 IPR018268 Ribosomal protein S10, conserved site GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0752 e5649fb035b13232cce9506ba78f4974 103 SUPERFAMILY SSF54999 6 103 1.7E-40 T 13-10-2018 IPR036838 Ribosomal protein S10 domain superfamily TOPB45_0752 e5649fb035b13232cce9506ba78f4974 103 TIGRFAM TIGR01049 rpsJ_bact: ribosomal protein uS10 5 103 6.4E-47 T 13-10-2018 IPR001848 Ribosomal protein S10 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_1343 08e65234b44f435f9c0d4414f1228139 232 Pfam PF07277 SapC 15 227 7.1E-41 T 13-10-2018 IPR010836 SapC TOPB45_1570 d2d5a92fd2e940e84238d9631b4bed2f 235 Pfam PF13144 Chaperone for flagella basal body P-ring formation 39 233 2.5E-40 T 13-10-2018 IPR017585 Flagella basal body P-ring formation protein FlgA, C-terminal TOPB45_1570 d2d5a92fd2e940e84238d9631b4bed2f 235 TIGRFAM TIGR03170 flgA_cterm: flagella basal body P-ring formation protein FlgA 102 233 1.6E-36 T 13-10-2018 IPR017585 Flagella basal body P-ring formation protein FlgA, C-terminal TOPB45_1570 d2d5a92fd2e940e84238d9631b4bed2f 235 SMART SM00858 110 172 1.2E-9 T 13-10-2018 IPR013974 SAF domain Reactome: R-HSA-4085001 TOPB45_1570 d2d5a92fd2e940e84238d9631b4bed2f 235 Gene3D G3DSA:2.30.30.760 176 235 3.6E-12 T 13-10-2018 TOPB45_1570 d2d5a92fd2e940e84238d9631b4bed2f 235 Gene3D G3DSA:3.90.1210.10 109 175 7.5E-8 T 13-10-2018 TOPB45_1358 30300355b7aecb7b4230f71fa7be57fa 103 Hamap MF_01363 50S ribosomal protein L21 [rplU]. 1 103 25.648 T 13-10-2018 IPR001787 Ribosomal protein L21 GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_1358 30300355b7aecb7b4230f71fa7be57fa 103 ProSitePatterns PS01169 Ribosomal protein L21 signature. 72 94 - T 13-10-2018 IPR018258 Ribosomal protein L21, conserved site GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_1358 30300355b7aecb7b4230f71fa7be57fa 103 TIGRFAM TIGR00061 L21: ribosomal protein bL21 3 101 7.7E-34 T 13-10-2018 IPR001787 Ribosomal protein L21 GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_1358 30300355b7aecb7b4230f71fa7be57fa 103 SUPERFAMILY SSF141091 3 102 4.71E-35 T 13-10-2018 IPR036164 L21-like superfamily Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_1358 30300355b7aecb7b4230f71fa7be57fa 103 Pfam PF00829 Ribosomal prokaryotic L21 protein 2 101 2.0E-38 T 13-10-2018 IPR028909 Ribosomal protein L21-like GO:0005840 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_1249 07db18283e46b17208ad5cb8fd639e71 141 Gene3D G3DSA:2.40.30.70 6 141 1.7E-39 T 13-10-2018 IPR036414 YaeB, N-terminal domain superfamily TOPB45_1249 07db18283e46b17208ad5cb8fd639e71 141 Pfam PF01980 Uncharacterised protein family UPF0066 21 132 9.0E-33 T 13-10-2018 IPR023370 YaeB-like, N-terminal domain TOPB45_1249 07db18283e46b17208ad5cb8fd639e71 141 TIGRFAM TIGR00104 tRNA_TsaA: tRNA-Thr(GGU) m(6)t(6)A37 methyltransferase TsaA 5 137 1.7E-33 T 13-10-2018 IPR023370 YaeB-like, N-terminal domain TOPB45_1249 07db18283e46b17208ad5cb8fd639e71 141 SUPERFAMILY SSF118196 5 137 7.98E-39 T 13-10-2018 IPR036413 YaeB-like superfamily TOPB45_0116 d971ae891da11a119d1d799e4dd3d475 208 Gene3D G3DSA:3.40.50.1580 1 207 6.4E-27 T 13-10-2018 TOPB45_0116 d971ae891da11a119d1d799e4dd3d475 208 Pfam PF01048 Phosphorylase superfamily 28 196 3.0E-15 T 13-10-2018 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 TOPB45_0116 d971ae891da11a119d1d799e4dd3d475 208 SUPERFAMILY SSF53167 17 186 8.38E-26 T 13-10-2018 IPR035994 Nucleoside phosphorylase superfamily GO:0003824|GO:0009116 TOPB45_1537 1f31490faff88da3fcce06bfcdff86be 170 Pfam PF07238 PilZ domain 69 157 4.7E-10 T 13-10-2018 IPR009875 PilZ domain GO:0035438 TOPB45_1537 1f31490faff88da3fcce06bfcdff86be 170 SUPERFAMILY SSF141371 84 159 5.89E-5 T 13-10-2018 TOPB45_0825 1d8587ef5fb9bc8fdf774436f7d9d097 791 Pfam PF02632 BioY family 54 193 1.4E-42 T 13-10-2018 IPR003784 BioY protein GO:0005886|GO:0015225|GO:0015878 TOPB45_0825 1d8587ef5fb9bc8fdf774436f7d9d097 791 SUPERFAMILY SSF56935 236 791 1.44E-69 T 13-10-2018 TOPB45_0825 1d8587ef5fb9bc8fdf774436f7d9d097 791 Gene3D G3DSA:1.10.1760.20 22 197 4.5E-52 T 13-10-2018 TOPB45_0825 1d8587ef5fb9bc8fdf774436f7d9d097 791 Pfam PF00593 TonB dependent receptor 386 769 1.1E-22 T 13-10-2018 IPR000531 TonB-dependent receptor-like, beta-barrel TOPB45_0825 1d8587ef5fb9bc8fdf774436f7d9d097 791 Gene3D G3DSA:2.170.130.10 227 354 2.7E-12 T 13-10-2018 IPR037066 TonB-dependent receptor, plug domain superfamily TOPB45_0825 1d8587ef5fb9bc8fdf774436f7d9d097 791 Gene3D G3DSA:2.40.170.20 367 791 2.1E-34 T 13-10-2018 IPR036942 TonB-dependent receptor-like, beta-barrel domain superfamily TOPB45_0825 1d8587ef5fb9bc8fdf774436f7d9d097 791 Pfam PF07715 TonB-dependent Receptor Plug Domain 249 350 4.3E-11 T 13-10-2018 IPR012910 TonB-dependent receptor, plug domain TOPB45_0066 d76e1e39fc61b3d82574be8ec35c35e5 255 PRINTS PR01840 Bacterial Sec-independent translocation TatC protein family signature 97 123 1.6E-7 T 13-10-2018 IPR002033 Sec-independent periplasmic protein translocase TatC GO:0016021 TOPB45_0066 d76e1e39fc61b3d82574be8ec35c35e5 255 PRINTS PR01840 Bacterial Sec-independent translocation TatC protein family signature 148 176 1.6E-7 T 13-10-2018 IPR002033 Sec-independent periplasmic protein translocase TatC GO:0016021 TOPB45_0066 d76e1e39fc61b3d82574be8ec35c35e5 255 Hamap MF_00902 Sec-independent protein translocase protein TatC [tatC]. 3 233 12.473 T 13-10-2018 IPR002033 Sec-independent periplasmic protein translocase TatC GO:0016021 TOPB45_0066 d76e1e39fc61b3d82574be8ec35c35e5 255 Pfam PF00902 Sec-independent protein translocase protein (TatC) 23 216 8.7E-36 T 13-10-2018 IPR002033 Sec-independent periplasmic protein translocase TatC GO:0016021 TOPB45_0782 41d9f729f4f536eaee3ac04b3f981b0e 166 Gene3D G3DSA:3.90.1030.10 1 116 1.5E-48 T 13-10-2018 IPR036373 Ribosomal protein L17 superfamily GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0782 41d9f729f4f536eaee3ac04b3f981b0e 166 Hamap MF_01368 50S ribosomal protein L17 [rplQ]. 5 116 26.85 T 13-10-2018 IPR000456 Ribosomal protein L17 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0782 41d9f729f4f536eaee3ac04b3f981b0e 166 TIGRFAM TIGR00059 L17: ribosomal protein bL17 8 117 2.2E-43 T 13-10-2018 IPR000456 Ribosomal protein L17 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0782 41d9f729f4f536eaee3ac04b3f981b0e 166 Pfam PF01196 Ribosomal protein L17 21 116 1.1E-36 T 13-10-2018 IPR000456 Ribosomal protein L17 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0782 41d9f729f4f536eaee3ac04b3f981b0e 166 SUPERFAMILY SSF64263 1 118 3.4E-47 T 13-10-2018 IPR036373 Ribosomal protein L17 superfamily GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0891 573b1abbdbf447da9c42eca90454f377 242 Gene3D G3DSA:3.30.1330.130 60 210 5.4E-11 T 13-10-2018 TOPB45_0891 573b1abbdbf447da9c42eca90454f377 242 Pfam PF02663 FmdE, Molybdenum formylmethanofuran dehydrogenase operon 72 211 5.7E-24 T 13-10-2018 IPR003814 Formylmethanofuran dehydrogenase, subunit E domain TOPB45_0891 573b1abbdbf447da9c42eca90454f377 242 SUPERFAMILY SSF143555 66 217 2.88E-18 T 13-10-2018 TOPB45_1238 e977a061db32d6f89be81a7461d6dc91 284 Pfam PF01256 Carbohydrate kinase 116 262 1.1E-10 T 13-10-2018 IPR000631 ATP-dependent (S)-NAD(P)H-hydrate dehydratase GO:0052855 Reactome: R-HSA-197264 TOPB45_1238 e977a061db32d6f89be81a7461d6dc91 284 SUPERFAMILY SSF53613 95 280 5.92E-21 T 13-10-2018 IPR029056 Ribokinase-like TOPB45_1238 e977a061db32d6f89be81a7461d6dc91 284 Gene3D G3DSA:3.40.1190.20 98 282 3.0E-18 T 13-10-2018 IPR029056 Ribokinase-like TOPB45_1238 e977a061db32d6f89be81a7461d6dc91 284 ProSitePatterns PS01050 YjeF C-terminal domain signature 2. 222 232 - T 13-10-2018 IPR017953 Carbohydrate kinase, predicted, conserved site TOPB45_1128 26a0f1da5d84c893f5cb814c96ddf916 210 Pfam PF01292 Prokaryotic cytochrome b561 7 202 9.1E-27 T 13-10-2018 IPR011577 Cytochrome b561, bacterial/Ni-hydrogenase GO:0009055|GO:0016021 TOPB45_1128 26a0f1da5d84c893f5cb814c96ddf916 210 SUPERFAMILY SSF81342 1 207 4.0E-33 T 13-10-2018 IPR016174 Di-haem cytochrome, transmembrane GO:0016020|GO:0022904 Reactome: R-HSA-611105 TOPB45_1128 26a0f1da5d84c893f5cb814c96ddf916 210 Gene3D G3DSA:1.20.950.20 1 192 1.2E-27 T 13-10-2018 TOPB45_1128 26a0f1da5d84c893f5cb814c96ddf916 210 PRINTS PR00161 Nickel-dependent hydrogenase/B-type cytochrome signature 127 146 2.1E-9 T 13-10-2018 IPR000516 Nickel-dependent hydrogenase b-type cytochrome subunit GO:0005506|GO:0009055|GO:0016021 TOPB45_1128 26a0f1da5d84c893f5cb814c96ddf916 210 PRINTS PR00161 Nickel-dependent hydrogenase/B-type cytochrome signature 9 32 2.1E-9 T 13-10-2018 IPR000516 Nickel-dependent hydrogenase b-type cytochrome subunit GO:0005506|GO:0009055|GO:0016021 TOPB45_0206 8956d276628a93864eee8664bc878c06 284 Pfam PF03734 L,D-transpeptidase catalytic domain 24 182 8.2E-14 T 13-10-2018 IPR005490 L,D-transpeptidase catalytic domain GO:0016740 TOPB45_0206 8956d276628a93864eee8664bc878c06 284 SUPERFAMILY SSF141523 23 183 2.22E-15 T 13-10-2018 IPR038063 L,D-transpeptidase catalytic domain-like TOPB45_0299 73a3d3c260c07479f47fc6616b81cb72 103 SUPERFAMILY SSF101498 39 97 3.66E-12 T 13-10-2018 IPR035890 Anti-sigma-28 factor FlgM superfamily TOPB45_0299 73a3d3c260c07479f47fc6616b81cb72 103 Pfam PF04316 Anti-sigma-28 factor, FlgM 45 95 1.7E-13 T 13-10-2018 IPR031316 Anti-sigma-28 factor FlgM, C-terminal TOPB45_0299 73a3d3c260c07479f47fc6616b81cb72 103 TIGRFAM TIGR03824 FlgM_jcvi: flagellar biosynthesis anti-sigma factor FlgM 22 97 4.1E-14 T 13-10-2018 IPR007412 Anti-sigma-28 factor, FlgM GO:0045892 TOPB45_1587 2b099fd80399ae8b8049df391e58c07a 274 Pfam PF13406 Transglycosylase SLT domain 29 247 1.4E-50 T 13-10-2018 IPR031304 Transglycosylase SLT domain 2 TOPB45_1587 2b099fd80399ae8b8049df391e58c07a 274 Gene3D G3DSA:1.10.530.10 189 251 2.2E-9 T 13-10-2018 TOPB45_1587 2b099fd80399ae8b8049df391e58c07a 274 Gene3D G3DSA:1.10.530.10 59 129 3.6E-8 T 13-10-2018 TOPB45_1587 2b099fd80399ae8b8049df391e58c07a 274 SUPERFAMILY SSF53955 67 273 1.32E-42 T 13-10-2018 IPR023346 Lysozyme-like domain superfamily TOPB45_1451 23b18d8e491ddea3c0744e9a1c7f22ed 164 Pfam PF08534 Redoxin 37 147 6.8E-9 T 13-10-2018 IPR013740 Redoxin GO:0016491 Reactome: R-HSA-3299685|Reactome: R-HSA-5628897 TOPB45_1451 23b18d8e491ddea3c0744e9a1c7f22ed 164 SUPERFAMILY SSF52833 5 160 1.88E-21 T 13-10-2018 IPR036249 Thioredoxin-like superfamily TOPB45_1451 23b18d8e491ddea3c0744e9a1c7f22ed 164 Gene3D G3DSA:3.40.30.10 25 163 7.1E-22 T 13-10-2018 TOPB45_1446 ef817fb06c655cbe9d8d84b72d90674e 421 Gene3D G3DSA:1.20.1270.370 61 262 1.2E-38 T 13-10-2018 TOPB45_1446 ef817fb06c655cbe9d8d84b72d90674e 421 Gene3D G3DSA:3.40.50.11900 278 421 2.4E-41 T 13-10-2018 TOPB45_1446 ef817fb06c655cbe9d8d84b72d90674e 421 Pfam PF06050 2-hydroxyglutaryl-CoA dehydratase, D-component 77 421 3.4E-79 T 13-10-2018 IPR010327 FldB/FldC dehydratase alpha/beta subunit TOPB45_1446 ef817fb06c655cbe9d8d84b72d90674e 421 Gene3D G3DSA:3.40.50.11890 70 196 1.2E-38 T 13-10-2018 TOPB45_0435 dc11bb644daf0bb08f4e8a9de84f7500 717 Pfam PF04453 Organic solvent tolerance protein 290 635 1.2E-9 T 13-10-2018 IPR007543 Organic solvent tolerance protein, C-terminal GO:0010033|GO:0019867|GO:0061024 TOPB45_1046 c94ee1b6ca809adeafd7141718bdc218 117 SMART SM00959 18 61 0.0059 T 13-10-2018 IPR011112 Rho termination factor, N-terminal GO:0006353 TOPB45_1140 de45ea864f2e8ac04abed37ed714b4ec 445 Gene3D G3DSA:1.20.58.220 3 220 5.1E-60 T 13-10-2018 IPR038078 PhoU-like domain superfamily TOPB45_1140 de45ea864f2e8ac04abed37ed714b4ec 445 Pfam PF01865 Protein of unknown function DUF47 231 444 1.5E-26 T 13-10-2018 IPR018445 Putative phosphate transport regulator TOPB45_1140 de45ea864f2e8ac04abed37ed714b4ec 445 Gene3D G3DSA:1.20.58.220 223 445 6.8E-36 T 13-10-2018 IPR038078 PhoU-like domain superfamily TOPB45_1140 de45ea864f2e8ac04abed37ed714b4ec 445 Pfam PF01895 PhoU domain 17 104 1.0E-22 T 13-10-2018 IPR026022 PhoU domain TOPB45_1140 de45ea864f2e8ac04abed37ed714b4ec 445 Pfam PF01895 PhoU domain 123 206 5.3E-18 T 13-10-2018 IPR026022 PhoU domain TOPB45_1140 de45ea864f2e8ac04abed37ed714b4ec 445 SUPERFAMILY SSF109755 247 425 3.53E-7 T 13-10-2018 TOPB45_1140 de45ea864f2e8ac04abed37ed714b4ec 445 SUPERFAMILY SSF109755 6 219 3.87E-56 T 13-10-2018 TOPB45_1140 de45ea864f2e8ac04abed37ed714b4ec 445 TIGRFAM TIGR02135 phoU_full: phosphate transport system regulatory protein PhoU 6 216 3.8E-52 T 13-10-2018 IPR028366 Phosphate transport system protein PhoU GO:0005737|GO:0030643|GO:0045936 TOPB45_1268 dce95cf9cfe7f7fcc81ed03c444d61a3 93 Pfam PF02325 YGGT family 14 83 1.0E-24 T 13-10-2018 IPR003425 CCB3/YggT GO:0016020 TOPB45_0800 02bd4e812263c063054e2de8db6ef243 422 Gene3D G3DSA:3.30.2010.10 56 138 1.2E-9 T 13-10-2018 TOPB45_0800 02bd4e812263c063054e2de8db6ef243 422 SMART SM00028 304 337 2.6 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_0800 02bd4e812263c063054e2de8db6ef243 422 SMART SM00028 338 371 25.0 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_0800 02bd4e812263c063054e2de8db6ef243 422 SMART SM00028 270 303 0.9 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_0800 02bd4e812263c063054e2de8db6ef243 422 SMART SM00028 372 405 4.0E-5 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_0800 02bd4e812263c063054e2de8db6ef243 422 Pfam PF07719 Tetratricopeptide repeat 375 405 4.4E-6 T 13-10-2018 IPR013105 Tetratricopeptide repeat 2 TOPB45_0800 02bd4e812263c063054e2de8db6ef243 422 SUPERFAMILY SSF48452 271 419 5.69E-27 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_0800 02bd4e812263c063054e2de8db6ef243 422 Pfam PF14559 Tetratricopeptide repeat 281 325 3.7E-6 T 13-10-2018 TOPB45_0800 02bd4e812263c063054e2de8db6ef243 422 SMART SM00386 352 385 120.0 T 13-10-2018 IPR003107 HAT (Half-A-TPR) repeat GO:0006396 TOPB45_0800 02bd4e812263c063054e2de8db6ef243 422 SMART SM00386 284 318 3.2 T 13-10-2018 IPR003107 HAT (Half-A-TPR) repeat GO:0006396 TOPB45_0800 02bd4e812263c063054e2de8db6ef243 422 SMART SM00386 386 422 160.0 T 13-10-2018 IPR003107 HAT (Half-A-TPR) repeat GO:0006396 TOPB45_0800 02bd4e812263c063054e2de8db6ef243 422 Gene3D G3DSA:1.25.40.10 208 422 7.5E-30 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_0800 02bd4e812263c063054e2de8db6ef243 422 Pfam PF01435 Peptidase family M48 62 240 2.8E-37 T 13-10-2018 IPR001915 Peptidase M48 GO:0004222|GO:0006508 TOPB45_0800 02bd4e812263c063054e2de8db6ef243 422 Pfam PF13181 Tetratricopeptide repeat 346 370 0.17 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_1390 1954fa5793005b6b16930408a076f7dd 475 TIGRFAM TIGR02395 rpoN_sigma: RNA polymerase sigma-54 factor 11 462 5.9E-126 T 13-10-2018 IPR000394 RNA polymerase sigma factor 54 GO:0001216|GO:0016987 TOPB45_1390 1954fa5793005b6b16930408a076f7dd 475 Gene3D G3DSA:1.10.10.60 403 463 6.2E-23 T 13-10-2018 TOPB45_1390 1954fa5793005b6b16930408a076f7dd 475 Pfam PF04963 Sigma-54 factor, core binding domain 99 286 6.5E-47 T 13-10-2018 IPR007046 RNA polymerase sigma factor 54, core-binding domain GO:0003677|GO:0006352 TOPB45_1390 1954fa5793005b6b16930408a076f7dd 475 PRINTS PR00045 Sigma-54 factor signature 172 189 2.8E-26 T 13-10-2018 IPR000394 RNA polymerase sigma factor 54 GO:0001216|GO:0016987 TOPB45_1390 1954fa5793005b6b16930408a076f7dd 475 PRINTS PR00045 Sigma-54 factor signature 379 390 2.8E-26 T 13-10-2018 IPR000394 RNA polymerase sigma factor 54 GO:0001216|GO:0016987 TOPB45_1390 1954fa5793005b6b16930408a076f7dd 475 PRINTS PR00045 Sigma-54 factor signature 438 456 2.8E-26 T 13-10-2018 IPR000394 RNA polymerase sigma factor 54 GO:0001216|GO:0016987 TOPB45_1390 1954fa5793005b6b16930408a076f7dd 475 PRINTS PR00045 Sigma-54 factor signature 363 375 2.8E-26 T 13-10-2018 IPR000394 RNA polymerase sigma factor 54 GO:0001216|GO:0016987 TOPB45_1390 1954fa5793005b6b16930408a076f7dd 475 Pfam PF00309 Sigma-54 factor, Activator interacting domain (AID) 7 50 1.1E-10 T 13-10-2018 IPR000394 RNA polymerase sigma factor 54 GO:0001216|GO:0016987 TOPB45_1390 1954fa5793005b6b16930408a076f7dd 475 PIRSF PIRSF000774 1 465 9.1E-126 T 13-10-2018 IPR000394 RNA polymerase sigma factor 54 GO:0001216|GO:0016987 TOPB45_1390 1954fa5793005b6b16930408a076f7dd 475 ProSitePatterns PS00717 Sigma-54 factors family signature 1. 351 370 - T 13-10-2018 IPR000394 RNA polymerase sigma factor 54 GO:0001216|GO:0016987 TOPB45_1390 1954fa5793005b6b16930408a076f7dd 475 Gene3D G3DSA:1.10.10.1330 106 221 9.0E-30 T 13-10-2018 IPR038709 RNA polymerase sigma-54 factor, core-binding domain superfamily TOPB45_1390 1954fa5793005b6b16930408a076f7dd 475 ProSitePatterns PS00718 Sigma-54 factors family signature 2. 443 450 - T 13-10-2018 IPR000394 RNA polymerase sigma factor 54 GO:0001216|GO:0016987 TOPB45_1390 1954fa5793005b6b16930408a076f7dd 475 Pfam PF04552 Sigma-54, DNA binding domain 304 462 2.3E-61 T 13-10-2018 IPR007634 RNA polymerase sigma factor 54, DNA-binding TOPB45_0913 07bb118abd2f7e08598262dc240347f0 143 Pfam PF10614 Type VIII secretion system (T8SS), CsgF protein 9 140 1.8E-46 T 13-10-2018 IPR018893 Type VIII secretion system, CsgF TOPB45_0931 4076e2f82da0d56bda49a608387efc7c 224 SUPERFAMILY SSF52540 1 215 7.55E-63 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0931 4076e2f82da0d56bda49a608387efc7c 224 Pfam PF00005 ABC transporter 17 155 2.4E-36 T 13-10-2018 IPR003439 ABC transporter-like GO:0005524|GO:0016887 TOPB45_0931 4076e2f82da0d56bda49a608387efc7c 224 Gene3D G3DSA:3.40.50.300 1 223 1.5E-61 T 13-10-2018 TOPB45_0931 4076e2f82da0d56bda49a608387efc7c 224 SMART SM00382 26 208 5.1E-10 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_0590 f78a39323b8fd42fb072ef2b0617f162 540 Hamap MF_01810 Membrane protein insertase YidC [yidC]. 3 538 19.811 T 13-10-2018 IPR019998 Membrane insertase YidC GO:0016021|GO:0032977 TOPB45_0590 f78a39323b8fd42fb072ef2b0617f162 540 TIGRFAM TIGR03593 yidC_nterm: membrane protein insertase, YidC/Oxa1 family, N-terminal domain 3 343 4.8E-52 T 13-10-2018 IPR028053 Membrane insertase YidC, N-terminal TOPB45_0590 f78a39323b8fd42fb072ef2b0617f162 540 Pfam PF02096 60Kd inner membrane protein 345 534 8.5E-60 T 13-10-2018 IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18 GO:0016021|GO:0032977 TOPB45_0590 f78a39323b8fd42fb072ef2b0617f162 540 PRINTS PR00701 60kDa inner membrane protein signature 162 182 6.6E-21 T 13-10-2018 IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18 GO:0016021|GO:0032977 TOPB45_0590 f78a39323b8fd42fb072ef2b0617f162 540 PRINTS PR00701 60kDa inner membrane protein signature 502 525 6.6E-21 T 13-10-2018 IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18 GO:0016021|GO:0032977 TOPB45_0590 f78a39323b8fd42fb072ef2b0617f162 540 PRINTS PR00701 60kDa inner membrane protein signature 466 488 6.6E-21 T 13-10-2018 IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18 GO:0016021|GO:0032977 TOPB45_0590 f78a39323b8fd42fb072ef2b0617f162 540 PRINTS PR00701 60kDa inner membrane protein signature 78 99 6.6E-21 T 13-10-2018 IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18 GO:0016021|GO:0032977 TOPB45_0590 f78a39323b8fd42fb072ef2b0617f162 540 PRINTS PR00701 60kDa inner membrane protein signature 1 20 6.6E-21 T 13-10-2018 IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18 GO:0016021|GO:0032977 TOPB45_0590 f78a39323b8fd42fb072ef2b0617f162 540 Gene3D G3DSA:2.70.98.90 71 321 4.5E-23 T 13-10-2018 IPR038221 YidC, periplasmic domain superfamily TOPB45_0590 f78a39323b8fd42fb072ef2b0617f162 540 TIGRFAM TIGR03592 yidC_oxa1_cterm: membrane protein insertase, YidC/Oxa1 family 344 534 1.1E-66 T 13-10-2018 IPR028055 Membrane insertase YidC/Oxa1, C-terminal Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0590 f78a39323b8fd42fb072ef2b0617f162 540 Pfam PF14849 YidC periplasmic domain 74 333 1.6E-35 T 13-10-2018 IPR038210 Membrane insertase YidC, periplasmic domain TOPB45_0590 f78a39323b8fd42fb072ef2b0617f162 540 PRINTS PR01900 YidC translocation/secretion protein signature 491 515 1.3E-19 T 13-10-2018 IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18 GO:0016021|GO:0032977 TOPB45_0590 f78a39323b8fd42fb072ef2b0617f162 540 PRINTS PR01900 YidC translocation/secretion protein signature 472 487 1.3E-19 T 13-10-2018 IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18 GO:0016021|GO:0032977 TOPB45_0590 f78a39323b8fd42fb072ef2b0617f162 540 PRINTS PR01900 YidC translocation/secretion protein signature 330 346 1.3E-19 T 13-10-2018 IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18 GO:0016021|GO:0032977 TOPB45_0871 d57357088eed9e094da5190512c2fce2 644 Gene3D G3DSA:3.10.620.30 330 487 6.7E-18 T 13-10-2018 TOPB45_0871 d57357088eed9e094da5190512c2fce2 644 SUPERFAMILY SSF54001 280 586 7.71E-46 T 13-10-2018 IPR038765 Papain-like cysteine peptidase superfamily TOPB45_0871 d57357088eed9e094da5190512c2fce2 644 Pfam PF11992 Domain of unknown function (DUF3488) 23 333 5.9E-57 T 13-10-2018 IPR021878 Protein of unknown function DUF3488 TOPB45_0871 d57357088eed9e094da5190512c2fce2 644 SMART SM00460 406 477 6.2E-23 T 13-10-2018 IPR002931 Transglutaminase-like TOPB45_0871 d57357088eed9e094da5190512c2fce2 644 Pfam PF01841 Transglutaminase-like superfamily 364 475 3.9E-20 T 13-10-2018 IPR002931 Transglutaminase-like TOPB45_0063 1b791fd81124bb38b31c8672f71772ed 438 TIGRFAM TIGR01026 fliI_yscN: ATPase, FliI/YscN family 4 434 1.8E-178 T 13-10-2018 IPR005714 ATPase, type III secretion system, FliI/YscN GO:0005737|GO:0009058|GO:0016887|GO:0030254|GO:0030257 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7980 TOPB45_0063 1b791fd81124bb38b31c8672f71772ed 438 Gene3D G3DSA:3.40.50.12240 14 437 1.1E-154 T 13-10-2018 TOPB45_0063 1b791fd81124bb38b31c8672f71772ed 438 ProSitePatterns PS00152 ATP synthase alpha and beta subunits signature. 345 354 - T 13-10-2018 IPR020003 ATPase, alpha/beta subunit, nucleotide-binding domain, active site GO:0005524 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7980 TOPB45_0063 1b791fd81124bb38b31c8672f71772ed 438 SMART SM00382 156 338 4.0E-9 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_0063 1b791fd81124bb38b31c8672f71772ed 438 SUPERFAMILY SSF52540 92 359 1.47E-95 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0063 1b791fd81124bb38b31c8672f71772ed 438 Pfam PF02874 ATP synthase alpha/beta family, beta-barrel domain 28 84 7.1E-5 T 13-10-2018 IPR004100 ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain GO:0046034|GO:1902600 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7980 TOPB45_0063 1b791fd81124bb38b31c8672f71772ed 438 Pfam PF00006 ATP synthase alpha/beta family, nucleotide-binding domain 144 354 1.0E-72 T 13-10-2018 IPR000194 ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain GO:0005524 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7980 TOPB45_1203 773756b7dd22edef19c3c5606aef5c06 259 SUPERFAMILY SSF54862 45 257 1.42E-54 T 13-10-2018 TOPB45_1203 773756b7dd22edef19c3c5606aef5c06 259 Pfam PF13247 4Fe-4S dicluster domain 119 224 2.4E-17 T 13-10-2018 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain TOPB45_1203 773756b7dd22edef19c3c5606aef5c06 259 Gene3D G3DSA:3.30.70.20 40 259 7.9E-56 T 13-10-2018 TOPB45_1203 773756b7dd22edef19c3c5606aef5c06 259 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 152 163 - T 13-10-2018 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site TOPB45_0520 868c1f74c2d788417927f5f95daca8a7 119 Pfam PF02391 MoaE protein 21 117 1.0E-18 T 13-10-2018 IPR003448 Molybdopterin biosynthesis MoaE GO:0006777 KEGG: 00790+2.8.1.12|MetaCyc: PWY-6823|MetaCyc: PWY-7887|Reactome: R-HSA-947581 TOPB45_0520 868c1f74c2d788417927f5f95daca8a7 119 Gene3D G3DSA:3.90.1170.40 3 119 3.9E-19 T 13-10-2018 IPR036563 Molybdopterin biosynthesis MoaE subunit superfamily GO:0006777 KEGG: 00790+2.8.1.12|MetaCyc: PWY-6823|MetaCyc: PWY-7887|Reactome: R-HSA-947581 TOPB45_0520 868c1f74c2d788417927f5f95daca8a7 119 SUPERFAMILY SSF54690 20 117 4.05E-19 T 13-10-2018 IPR036563 Molybdopterin biosynthesis MoaE subunit superfamily GO:0006777 KEGG: 00790+2.8.1.12|MetaCyc: PWY-6823|MetaCyc: PWY-7887|Reactome: R-HSA-947581 TOPB45_0615 d64ecd96cb6693bebf172782bf6707d0 274 SUPERFAMILY SSF51735 5 146 3.78E-29 T 13-10-2018 IPR036291 NAD(P)-binding domain superfamily TOPB45_0615 d64ecd96cb6693bebf172782bf6707d0 274 SUPERFAMILY SSF48179 149 257 1.81E-22 T 13-10-2018 IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily GO:0055114 TOPB45_0615 d64ecd96cb6693bebf172782bf6707d0 274 Gene3D G3DSA:3.40.50.720 1 154 1.3E-35 T 13-10-2018 TOPB45_0615 d64ecd96cb6693bebf172782bf6707d0 274 Gene3D G3DSA:1.10.3660.10 156 266 1.1E-17 T 13-10-2018 TOPB45_0615 d64ecd96cb6693bebf172782bf6707d0 274 Pfam PF02153 Prephenate dehydrogenase 39 252 9.2E-36 T 13-10-2018 IPR003099 Prephenate dehydrogenase GO:0004665|GO:0006571|GO:0008977|GO:0055114 KEGG: 00400+1.3.1.12|KEGG: 00401+1.3.1.12|MetaCyc: PWY-7303 TOPB45_1273 9aae5b2275f6f784ccefcade8337d16c 738 SUPERFAMILY SSF52096 485 735 6.75E-46 T 13-10-2018 IPR029045 ClpP/crotonase-like domain superfamily TOPB45_1273 9aae5b2275f6f784ccefcade8337d16c 738 Gene3D G3DSA:3.90.226.10 481 730 2.9E-45 T 13-10-2018 TOPB45_1273 9aae5b2275f6f784ccefcade8337d16c 738 SUPERFAMILY SSF52096 55 321 5.77E-47 T 13-10-2018 IPR029045 ClpP/crotonase-like domain superfamily TOPB45_1273 9aae5b2275f6f784ccefcade8337d16c 738 Pfam PF03255 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit 30 172 7.2E-28 T 13-10-2018 IPR001095 Acetyl-CoA carboxylase, alpha subunit GO:0003989|GO:0006633|GO:0009317 MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6722 TOPB45_1273 9aae5b2275f6f784ccefcade8337d16c 738 PRINTS PR01070 Acetyl-CoA carboxylase carboxyl transferase beta subunit signature 680 691 1.6E-8 T 13-10-2018 IPR000438 Acetyl-CoA carboxylase carboxyl transferase, beta subunit GO:0003989|GO:0006633|GO:0009317 MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6722 TOPB45_1273 9aae5b2275f6f784ccefcade8337d16c 738 PRINTS PR01070 Acetyl-CoA carboxylase carboxyl transferase beta subunit signature 614 632 1.6E-8 T 13-10-2018 IPR000438 Acetyl-CoA carboxylase carboxyl transferase, beta subunit GO:0003989|GO:0006633|GO:0009317 MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6722 TOPB45_1273 9aae5b2275f6f784ccefcade8337d16c 738 PRINTS PR01070 Acetyl-CoA carboxylase carboxyl transferase beta subunit signature 579 593 1.6E-8 T 13-10-2018 IPR000438 Acetyl-CoA carboxylase carboxyl transferase, beta subunit GO:0003989|GO:0006633|GO:0009317 MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6722 TOPB45_0651 535df29ca780c3c6179005568666c862 197 SMART SM00028 24 57 210.0 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_0651 535df29ca780c3c6179005568666c862 197 SMART SM00028 144 177 0.12 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_0651 535df29ca780c3c6179005568666c862 197 SMART SM00028 64 97 0.011 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_0651 535df29ca780c3c6179005568666c862 197 SMART SM00028 104 137 220.0 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_0651 535df29ca780c3c6179005568666c862 197 SUPERFAMILY SSF48452 44 183 2.21E-22 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_0651 535df29ca780c3c6179005568666c862 197 Pfam PF13424 Tetratricopeptide repeat 103 175 1.7E-11 T 13-10-2018 TOPB45_0651 535df29ca780c3c6179005568666c862 197 Pfam PF13424 Tetratricopeptide repeat 35 96 4.9E-9 T 13-10-2018 TOPB45_0651 535df29ca780c3c6179005568666c862 197 Gene3D G3DSA:1.25.40.10 12 196 4.0E-27 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_1270 56fc6e911d73ecc13326172b8a3bf99f 316 Gene3D G3DSA:3.40.50.150 108 316 1.0E-60 T 13-10-2018 TOPB45_1270 56fc6e911d73ecc13326172b8a3bf99f 316 TIGRFAM TIGR00446 nop2p: NOL1/NOP2/sun family putative RNA methylase 40 313 3.7E-67 T 13-10-2018 IPR011023 Nop2p GO:0003723|GO:0006364|GO:0008757 Reactome: R-HSA-6790901|Reactome: R-HSA-8869496 TOPB45_1270 56fc6e911d73ecc13326172b8a3bf99f 316 PRINTS PR02008 RNA (C5-cytosine) methyltransferase signature 297 314 9.2E-22 T 13-10-2018 IPR023267 RNA (C5-cytosine) methyltransferase TOPB45_1270 56fc6e911d73ecc13326172b8a3bf99f 316 PRINTS PR02008 RNA (C5-cytosine) methyltransferase signature 120 130 9.2E-22 T 13-10-2018 IPR023267 RNA (C5-cytosine) methyltransferase TOPB45_1270 56fc6e911d73ecc13326172b8a3bf99f 316 PRINTS PR02008 RNA (C5-cytosine) methyltransferase signature 185 197 9.2E-22 T 13-10-2018 IPR023267 RNA (C5-cytosine) methyltransferase TOPB45_1270 56fc6e911d73ecc13326172b8a3bf99f 316 PRINTS PR02008 RNA (C5-cytosine) methyltransferase signature 236 252 9.2E-22 T 13-10-2018 IPR023267 RNA (C5-cytosine) methyltransferase TOPB45_1270 56fc6e911d73ecc13326172b8a3bf99f 316 Gene3D G3DSA:3.30.70.3130 2 104 1.3E-10 T 13-10-2018 TOPB45_1270 56fc6e911d73ecc13326172b8a3bf99f 316 Pfam PF01189 16S rRNA methyltransferase RsmB/F 108 313 2.5E-43 T 13-10-2018 IPR001678 SAM-dependent methyltransferase RsmB/NOP2-type GO:0008168 TOPB45_1270 56fc6e911d73ecc13326172b8a3bf99f 316 SUPERFAMILY SSF53335 17 315 1.14E-51 T 13-10-2018 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TOPB45_1510 1639f902f5c89a1264d1464d6caeada8 293 Gene3D G3DSA:3.90.550.10 1 292 4.2E-78 T 13-10-2018 IPR029044 Nucleotide-diphospho-sugar transferases TOPB45_1510 1639f902f5c89a1264d1464d6caeada8 293 Pfam PF00483 Nucleotidyl transferase 4 269 1.9E-27 T 13-10-2018 IPR005835 Nucleotidyl transferase domain GO:0009058|GO:0016779 TOPB45_1510 1639f902f5c89a1264d1464d6caeada8 293 SUPERFAMILY SSF53448 1 272 6.98E-56 T 13-10-2018 IPR029044 Nucleotide-diphospho-sugar transferases TOPB45_0395 8a84b10e6d86211fad5676894881e490 402 Gene3D G3DSA:3.20.20.20 104 400 5.5E-123 T 13-10-2018 IPR011005 Dihydropteroate synthase-like GO:0044237 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 TOPB45_0395 8a84b10e6d86211fad5676894881e490 402 Pfam PF03599 CO dehydrogenase/acetyl-CoA synthase delta subunit 105 345 3.8E-43 T 13-10-2018 IPR016041 CO dehydrogenase/acetyl-CoA synthase delta subunit, TIM barrel TOPB45_0395 8a84b10e6d86211fad5676894881e490 402 SUPERFAMILY SSF51717 139 350 6.8E-15 T 13-10-2018 IPR011005 Dihydropteroate synthase-like GO:0044237 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 TOPB45_1621 a700497140a7e07fefe9a3ae6aca0025 211 Pfam PF01797 Transposase IS200 like 68 141 4.9E-6 T 13-10-2018 IPR002686 Transposase IS200-like GO:0003677|GO:0004803|GO:0006313 TOPB45_1621 a700497140a7e07fefe9a3ae6aca0025 211 Gene3D G3DSA:3.30.70.1290 1 188 4.3E-32 T 13-10-2018 IPR036515 Transposase IS200-like superfamily GO:0003677|GO:0004803|GO:0006313 TOPB45_1621 a700497140a7e07fefe9a3ae6aca0025 211 SMART SM01321 2 143 1.2E-9 T 13-10-2018 IPR002686 Transposase IS200-like GO:0003677|GO:0004803|GO:0006313 TOPB45_1621 a700497140a7e07fefe9a3ae6aca0025 211 SUPERFAMILY SSF143422 64 149 3.53E-14 T 13-10-2018 IPR036515 Transposase IS200-like superfamily GO:0003677|GO:0004803|GO:0006313 TOPB45_1336 65d13f117e61af56fbc8c30bd0d225b9 333 Gene3D G3DSA:2.30.330.10 245 330 3.5E-14 T 13-10-2018 IPR036429 SpoA-like superfamily TOPB45_1336 65d13f117e61af56fbc8c30bd0d225b9 333 SUPERFAMILY SSF101801 248 322 6.8E-20 T 13-10-2018 IPR036429 SpoA-like superfamily TOPB45_1336 65d13f117e61af56fbc8c30bd0d225b9 333 PRINTS PR00955 Flagellar motor switch protein FliM signature 115 134 6.8E-19 T 13-10-2018 IPR001689 Flagellar motor switch protein FliM GO:0003774|GO:0009425|GO:0071973 TOPB45_1336 65d13f117e61af56fbc8c30bd0d225b9 333 PRINTS PR00955 Flagellar motor switch protein FliM signature 212 230 6.8E-19 T 13-10-2018 IPR001689 Flagellar motor switch protein FliM GO:0003774|GO:0009425|GO:0071973 TOPB45_1336 65d13f117e61af56fbc8c30bd0d225b9 333 PRINTS PR00955 Flagellar motor switch protein FliM signature 90 106 6.8E-19 T 13-10-2018 IPR001689 Flagellar motor switch protein FliM GO:0003774|GO:0009425|GO:0071973 TOPB45_1336 65d13f117e61af56fbc8c30bd0d225b9 333 PRINTS PR00955 Flagellar motor switch protein FliM signature 3 16 6.8E-19 T 13-10-2018 IPR001689 Flagellar motor switch protein FliM GO:0003774|GO:0009425|GO:0071973 TOPB45_1336 65d13f117e61af56fbc8c30bd0d225b9 333 SUPERFAMILY SSF103039 56 230 8.37E-20 T 13-10-2018 IPR028976 CheC-like superfamily TOPB45_1336 65d13f117e61af56fbc8c30bd0d225b9 333 TIGRFAM TIGR01397 fliM_switch: flagellar motor switch protein FliM 4 319 1.1E-88 T 13-10-2018 IPR001689 Flagellar motor switch protein FliM GO:0003774|GO:0009425|GO:0071973 TOPB45_1336 65d13f117e61af56fbc8c30bd0d225b9 333 PIRSF PIRSF002888 2 331 1.0E-91 T 13-10-2018 IPR001689 Flagellar motor switch protein FliM GO:0003774|GO:0009425|GO:0071973 TOPB45_1336 65d13f117e61af56fbc8c30bd0d225b9 333 Gene3D G3DSA:3.40.1550.10 47 231 1.3E-49 T 13-10-2018 IPR028976 CheC-like superfamily TOPB45_1336 65d13f117e61af56fbc8c30bd0d225b9 333 Pfam PF01052 Type III flagellar switch regulator (C-ring) FliN C-term 254 321 1.8E-24 T 13-10-2018 IPR001543 Surface presentation of antigen (SpoA) TOPB45_1336 65d13f117e61af56fbc8c30bd0d225b9 333 Pfam PF02154 Flagellar motor switch protein FliM 39 230 2.1E-50 T 13-10-2018 IPR001689 Flagellar motor switch protein FliM GO:0003774|GO:0009425|GO:0071973 TOPB45_1477 25436d15284c742d863aea8bd1dc54c6 84 Pfam PF04296 Protein of unknown function (DUF448) 10 74 1.3E-14 T 13-10-2018 IPR007393 Domain of unknown function DUF448 TOPB45_1477 25436d15284c742d863aea8bd1dc54c6 84 SUPERFAMILY SSF64376 6 75 1.07E-14 T 13-10-2018 IPR035931 YlxR-like superfamily TOPB45_1477 25436d15284c742d863aea8bd1dc54c6 84 Gene3D G3DSA:3.30.1230.10 1 83 1.3E-15 T 13-10-2018 IPR035931 YlxR-like superfamily TOPB45_0875 d8833ee9d8f0a2fa189bb5c141bc6542 432 Gene3D G3DSA:2.40.50.140 2 74 5.9E-18 T 13-10-2018 TOPB45_0875 d8833ee9d8f0a2fa189bb5c141bc6542 432 Pfam PF05958 tRNA (Uracil-5-)-methyltransferase 85 431 6.1E-17 T 13-10-2018 IPR010280 (Uracil-5)-methyltransferase family GO:0006396|GO:0008173 TOPB45_0875 d8833ee9d8f0a2fa189bb5c141bc6542 432 TIGRFAM TIGR00479 rumA: 23S rRNA (uracil-5-)-methyltransferase RumA 14 423 5.3E-70 T 13-10-2018 TOPB45_0875 d8833ee9d8f0a2fa189bb5c141bc6542 432 SUPERFAMILY SSF53335 63 430 7.6E-51 T 13-10-2018 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TOPB45_0875 d8833ee9d8f0a2fa189bb5c141bc6542 432 ProSitePatterns PS01231 RNA methyltransferase trmA family signature 2. 413 423 - T 13-10-2018 IPR030391 RNA methyltransferase TrmA, conserved site TOPB45_0875 d8833ee9d8f0a2fa189bb5c141bc6542 432 Gene3D G3DSA:3.40.50.150 75 425 3.1E-61 T 13-10-2018 TOPB45_0875 d8833ee9d8f0a2fa189bb5c141bc6542 432 ProSitePatterns PS01230 RNA methyltransferase trmA family signature 1. 362 392 - T 13-10-2018 IPR030390 RNA methyltransferase TrmA, active site TOPB45_0875 d8833ee9d8f0a2fa189bb5c141bc6542 432 Pfam PF01938 TRAM domain 5 53 1.6E-7 T 13-10-2018 IPR002792 TRAM domain TOPB45_0875 d8833ee9d8f0a2fa189bb5c141bc6542 432 Gene3D G3DSA:3.40.1350.30 123 262 3.1E-61 T 13-10-2018 TOPB45_0875 d8833ee9d8f0a2fa189bb5c141bc6542 432 SUPERFAMILY SSF50249 3 61 5.71E-9 T 13-10-2018 IPR012340 Nucleic acid-binding, OB-fold TOPB45_0418 f6ec19c0f1b6420eef462075483ea4da 756 Pfam PF01300 Telomere recombination 211 384 8.1E-47 T 13-10-2018 IPR006070 YrdC-like domain GO:0003725 TOPB45_0418 f6ec19c0f1b6420eef462075483ea4da 756 SUPERFAMILY SSF54975 3 88 5.67E-24 T 13-10-2018 IPR036046 Acylphosphatase-like domain superfamily KEGG: 00620+3.6.1.7|KEGG: 00627+3.6.1.7 TOPB45_0418 f6ec19c0f1b6420eef462075483ea4da 756 SUPERFAMILY SSF55821 176 394 7.94E-44 T 13-10-2018 IPR017945 DHBP synthase RibB-like alpha/beta domain superfamily TOPB45_0418 f6ec19c0f1b6420eef462075483ea4da 756 TIGRFAM TIGR00143 hypF: carbamoyltransferase HypF 7 749 5.2E-247 T 13-10-2018 IPR004421 Carbamoyltransferase, HypF-type GO:0016743|GO:0046872|GO:0046944 TOPB45_0418 f6ec19c0f1b6420eef462075483ea4da 756 Pfam PF07503 HypF finger 157 190 5.2E-17 T 13-10-2018 IPR011125 Zinc finger, HypF-type GO:0008270 TOPB45_0418 f6ec19c0f1b6420eef462075483ea4da 756 Pfam PF07503 HypF finger 107 140 1.9E-18 T 13-10-2018 IPR011125 Zinc finger, HypF-type GO:0008270 TOPB45_0418 f6ec19c0f1b6420eef462075483ea4da 756 Gene3D G3DSA:3.30.110.120 254 372 7.5E-151 T 13-10-2018 TOPB45_0418 f6ec19c0f1b6420eef462075483ea4da 756 PIRSF PIRSF006256 1 755 4.8E-284 T 13-10-2018 IPR004421 Carbamoyltransferase, HypF-type GO:0016743|GO:0046872|GO:0046944 TOPB45_0418 f6ec19c0f1b6420eef462075483ea4da 756 Pfam PF00708 Acylphosphatase 6 86 6.7E-23 T 13-10-2018 IPR001792 Acylphosphatase-like domain KEGG: 00620+3.6.1.7|KEGG: 00627+3.6.1.7 TOPB45_0418 f6ec19c0f1b6420eef462075483ea4da 756 Gene3D G3DSA:3.30.420.360 384 748 3.4E-126 T 13-10-2018 TOPB45_0418 f6ec19c0f1b6420eef462075483ea4da 756 SUPERFAMILY SSF53067 199 748 9.71E-5 T 13-10-2018 TOPB45_0418 f6ec19c0f1b6420eef462075483ea4da 756 Gene3D G3DSA:3.90.870.50 7 363 7.5E-151 T 13-10-2018 TOPB45_0418 f6ec19c0f1b6420eef462075483ea4da 756 ProSitePatterns PS00150 Acylphosphatase signature 1. 9 19 - T 13-10-2018 IPR017968 Acylphosphatase, conserved site KEGG: 00620+3.6.1.7|KEGG: 00627+3.6.1.7 TOPB45_0418 f6ec19c0f1b6420eef462075483ea4da 756 Gene3D G3DSA:3.30.420.350 486 736 3.4E-126 T 13-10-2018 TOPB45_1272 bdc07e2b5dd6c0e38991c14ffdc37b66 463 Gene3D G3DSA:3.30.1490.20 127 208 3.0E-90 T 13-10-2018 IPR013815 ATP-grasp fold, subdomain 1 GO:0005524 TOPB45_1272 bdc07e2b5dd6c0e38991c14ffdc37b66 463 Gene3D G3DSA:3.30.470.20 80 451 3.0E-90 T 13-10-2018 TOPB45_1272 bdc07e2b5dd6c0e38991c14ffdc37b66 463 SUPERFAMILY SSF52440 2 108 1.08E-38 T 13-10-2018 IPR016185 Pre-ATP-grasp domain superfamily TOPB45_1272 bdc07e2b5dd6c0e38991c14ffdc37b66 463 SUPERFAMILY SSF51246 350 450 5.02E-17 T 13-10-2018 IPR011054 Rudiment single hybrid motif Reactome: R-HSA-196780 TOPB45_1272 bdc07e2b5dd6c0e38991c14ffdc37b66 463 Pfam PF02785 Biotin carboxylase C-terminal domain 355 437 4.5E-13 T 13-10-2018 IPR005482 Biotin carboxylase, C-terminal Reactome: R-HSA-196780|Reactome: R-HSA-3371599 TOPB45_1272 bdc07e2b5dd6c0e38991c14ffdc37b66 463 Gene3D G3DSA:3.40.50.20 1 79 3.0E-28 T 13-10-2018 TOPB45_1272 bdc07e2b5dd6c0e38991c14ffdc37b66 463 ProSitePatterns PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 300 307 - T 13-10-2018 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 TOPB45_1272 bdc07e2b5dd6c0e38991c14ffdc37b66 463 SUPERFAMILY SSF56059 78 362 1.54E-36 T 13-10-2018 TOPB45_1272 bdc07e2b5dd6c0e38991c14ffdc37b66 463 Pfam PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 116 341 1.6E-31 T 13-10-2018 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 TOPB45_1272 bdc07e2b5dd6c0e38991c14ffdc37b66 463 Pfam PF00289 Biotin carboxylase, N-terminal domain 2 106 1.5E-35 T 13-10-2018 IPR005481 Biotin carboxylase-like, N-terminal domain Reactome: R-HSA-196780|Reactome: R-HSA-3371599 TOPB45_1272 bdc07e2b5dd6c0e38991c14ffdc37b66 463 SMART SM00878 355 462 3.4E-9 T 13-10-2018 IPR005482 Biotin carboxylase, C-terminal Reactome: R-HSA-196780|Reactome: R-HSA-3371599 TOPB45_0616 58f9a8ec3bbd83a3d6e1cc48e74f749c 263 ProSitePatterns PS01311 Prolipoprotein diacylglyceryl transferase signature. 138 150 - T 13-10-2018 IPR001640 Prolipoprotein diacylglyceryl transferase GO:0016020|GO:0016757|GO:0042158 TOPB45_0616 58f9a8ec3bbd83a3d6e1cc48e74f749c 263 Pfam PF01790 Prolipoprotein diacylglyceryl transferase 9 252 3.5E-76 T 13-10-2018 IPR001640 Prolipoprotein diacylglyceryl transferase GO:0016020|GO:0016757|GO:0042158 TOPB45_0616 58f9a8ec3bbd83a3d6e1cc48e74f749c 263 Hamap MF_01147 Prolipoprotein diacylglyceryl transferase [lgt]. 6 258 19.181 T 13-10-2018 IPR001640 Prolipoprotein diacylglyceryl transferase GO:0016020|GO:0016757|GO:0042158 TOPB45_0616 58f9a8ec3bbd83a3d6e1cc48e74f749c 263 TIGRFAM TIGR00544 lgt: prolipoprotein diacylglyceryl transferase 3 252 2.3E-66 T 13-10-2018 IPR001640 Prolipoprotein diacylglyceryl transferase GO:0016020|GO:0016757|GO:0042158 TOPB45_0575 fd91743bfeca9eba2d2cf20d944f330a 187 SUPERFAMILY SSF52499 5 187 1.22E-43 T 13-10-2018 IPR036380 Isochorismatase-like superfamily GO:0003824 TOPB45_0575 fd91743bfeca9eba2d2cf20d944f330a 187 Pfam PF00857 Isochorismatase family 12 164 3.3E-25 T 13-10-2018 IPR000868 Isochorismatase-like GO:0003824 TOPB45_0575 fd91743bfeca9eba2d2cf20d944f330a 187 Gene3D G3DSA:3.40.50.850 4 187 4.0E-48 T 13-10-2018 IPR036380 Isochorismatase-like superfamily GO:0003824 TOPB45_1315 ab7a6155fe0ae45a853e931006e98d2a 350 SUPERFAMILY SSF51726 8 341 2.62E-20 T 13-10-2018 IPR038071 UROD/MetE-like superfamily Reactome: R-HSA-189451 TOPB45_0765 b81ebd93bda696006d1407b5313f16d1 179 Gene3D G3DSA:3.30.1440.10 2 179 4.6E-78 T 13-10-2018 IPR022803 Ribosomal protein L5 domain superfamily Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0765 b81ebd93bda696006d1407b5313f16d1 179 SUPERFAMILY SSF55282 4 178 4.24E-74 T 13-10-2018 IPR022803 Ribosomal protein L5 domain superfamily Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0765 b81ebd93bda696006d1407b5313f16d1 179 Pfam PF00673 ribosomal L5P family C-terminus 84 177 7.3E-39 T 13-10-2018 IPR031309 Ribosomal protein L5, C-terminal Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0765 b81ebd93bda696006d1407b5313f16d1 179 PIRSF PIRSF002161 1 179 9.1E-66 T 13-10-2018 IPR002132 Ribosomal protein L5 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0765 b81ebd93bda696006d1407b5313f16d1 179 Pfam PF00281 Ribosomal protein L5 24 80 7.1E-25 T 13-10-2018 IPR031310 Ribosomal protein L5, N-terminal Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0765 b81ebd93bda696006d1407b5313f16d1 179 Hamap MF_01333_B 50S ribosomal protein L5 [rplE]. 1 179 41.708 T 13-10-2018 IPR020930 Ribosomal protein L5, bacterial-type GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0523 b862bd78da00b37aa2c8de506966e8f6 97 Pfam PF04023 FeoA domain 2 70 6.5E-10 T 13-10-2018 IPR007167 Ferrous iron transporter FeoA domain GO:0046914 TOPB45_0523 b862bd78da00b37aa2c8de506966e8f6 97 SMART SM00899 1 71 4.8E-12 T 13-10-2018 IPR007167 Ferrous iron transporter FeoA domain GO:0046914 TOPB45_0523 b862bd78da00b37aa2c8de506966e8f6 97 Gene3D G3DSA:2.30.30.90 1 76 7.3E-12 T 13-10-2018 IPR038157 Ferrous iron transporter, core domain TOPB45_0523 b862bd78da00b37aa2c8de506966e8f6 97 SUPERFAMILY SSF50037 3 72 5.04E-11 T 13-10-2018 IPR008988 Transcriptional repressor, C-terminal TOPB45_0300 94d654842c841cb594d68b2caa1e7751 404 Pfam PF01467 Cytidylyltransferase-like 272 365 3.2E-18 T 13-10-2018 IPR004821 Cytidyltransferase-like domain GO:0003824|GO:0009058 TOPB45_0300 94d654842c841cb594d68b2caa1e7751 404 TIGRFAM TIGR02199 rfaE_dom_II: bifunctional protein RfaE, domain II 259 399 8.4E-62 T 13-10-2018 IPR011914 RfaE bifunctional protein, domain II GO:0005975|GO:0016773|GO:0016779 KEGG: 00540+2.7.7.70+2.7.1.167 TOPB45_0300 94d654842c841cb594d68b2caa1e7751 404 TIGRFAM TIGR00125 cyt_tran_rel: cytidyltransferase-like domain 270 334 3.1E-15 T 13-10-2018 IPR004821 Cytidyltransferase-like domain GO:0003824|GO:0009058 TOPB45_0300 94d654842c841cb594d68b2caa1e7751 404 Gene3D G3DSA:3.40.50.620 240 404 7.4E-45 T 13-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TOPB45_0300 94d654842c841cb594d68b2caa1e7751 404 Pfam PF00795 Carbon-nitrogen hydrolase 6 222 2.2E-26 T 13-10-2018 IPR003010 Carbon-nitrogen hydrolase GO:0006807 TOPB45_0300 94d654842c841cb594d68b2caa1e7751 404 SUPERFAMILY SSF56317 2 229 5.62E-44 T 13-10-2018 IPR036526 Carbon-nitrogen hydrolase superfamily TOPB45_0300 94d654842c841cb594d68b2caa1e7751 404 SUPERFAMILY SSF52374 269 398 1.88E-25 T 13-10-2018 TOPB45_0300 94d654842c841cb594d68b2caa1e7751 404 Gene3D G3DSA:3.60.110.10 1 236 7.9E-47 T 13-10-2018 IPR036526 Carbon-nitrogen hydrolase superfamily TOPB45_0021 195f373fc95a7af625eed997481f67d8 338 Pfam PF04055 Radical SAM superfamily 78 235 2.8E-24 T 13-10-2018 IPR007197 Radical SAM GO:0003824|GO:0051536 TOPB45_0021 195f373fc95a7af625eed997481f67d8 338 Gene3D G3DSA:3.20.20.70 66 282 1.8E-36 T 13-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 TOPB45_0021 195f373fc95a7af625eed997481f67d8 338 PIRSF PIRSF004869 1 313 4.1E-105 T 13-10-2018 IPR016431 Pyruvate-formate lyase-activating enzyme, predicted TOPB45_0021 195f373fc95a7af625eed997481f67d8 338 SUPERFAMILY SSF102114 45 314 1.02E-37 T 13-10-2018 TOPB45_0021 195f373fc95a7af625eed997481f67d8 338 TIGRFAM TIGR04337 AmmeMemoSam_rS: AmmeMemoRadiSam system radical SAM enzyme 7 337 4.2E-104 T 13-10-2018 IPR027596 AmmeMemoRadiSam system radical SAM enzyme TOPB45_0021 195f373fc95a7af625eed997481f67d8 338 SMART SM00729 72 278 0.0014 T 13-10-2018 IPR006638 Elp3/MiaB/NifB GO:0003824|GO:0051536 TOPB45_1287 debbfc1f5704af28c5baff42b12de5f3 429 Gene3D G3DSA:3.30.499.20 7 272 1.8E-96 T 13-10-2018 TOPB45_1287 debbfc1f5704af28c5baff42b12de5f3 429 ProSitePatterns PS00450 Aconitase family signature 1. 296 312 - T 13-10-2018 IPR018136 Aconitase family, 4Fe-4S cluster binding site KEGG: 00290+4.2.1.33 TOPB45_1287 debbfc1f5704af28c5baff42b12de5f3 429 SUPERFAMILY SSF53732 3 423 3.27E-136 T 13-10-2018 IPR036008 Aconitase, iron-sulfur domain KEGG: 00290+4.2.1.33 TOPB45_1287 debbfc1f5704af28c5baff42b12de5f3 429 TIGRFAM TIGR02086 IPMI_arch: 3-isopropylmalate dehydratase, large subunit 6 421 1.5E-156 T 13-10-2018 IPR011826 Homoaconitase/3-isopropylmalate dehydratase, large subunit, prokaryotic GO:0003861|GO:0009098|GO:0051539 KEGG: 00290+4.2.1.33 TOPB45_1287 debbfc1f5704af28c5baff42b12de5f3 429 Gene3D G3DSA:3.30.499.10 276 428 6.8E-53 T 13-10-2018 IPR015931 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 KEGG: 00290+4.2.1.33 TOPB45_1287 debbfc1f5704af28c5baff42b12de5f3 429 TIGRFAM TIGR01343 hacA_fam: homoaconitate hydratase family protein 7 420 7.4E-173 T 13-10-2018 IPR006251 Homoaconitase/3-isopropylmalate dehydratase, large subunit GO:0008652|GO:0016836|GO:0051539 KEGG: 00290+4.2.1.33 TOPB45_1287 debbfc1f5704af28c5baff42b12de5f3 429 ProSitePatterns PS01244 Aconitase family signature 2. 356 369 - T 13-10-2018 IPR018136 Aconitase family, 4Fe-4S cluster binding site KEGG: 00290+4.2.1.33 TOPB45_1287 debbfc1f5704af28c5baff42b12de5f3 429 TIGRFAM TIGR02083 LEU2: 3-isopropylmalate dehydratase, large subunit 6 423 6.1E-212 T 13-10-2018 IPR011823 3-isopropylmalate dehydratase, large subunit, bacteria GO:0003861|GO:0009098|GO:0051539 KEGG: 00290+4.2.1.33 TOPB45_1287 debbfc1f5704af28c5baff42b12de5f3 429 Hamap MF_01027 3-isopropylmalate dehydratase large subunit [leuC]. 6 423 48.951 T 13-10-2018 IPR011826 Homoaconitase/3-isopropylmalate dehydratase, large subunit, prokaryotic GO:0003861|GO:0009098|GO:0051539 KEGG: 00290+4.2.1.33 TOPB45_1287 debbfc1f5704af28c5baff42b12de5f3 429 PRINTS PR00415 Aconitase family signature 117 130 4.4E-17 T 13-10-2018 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain KEGG: 00290+4.2.1.33 TOPB45_1287 debbfc1f5704af28c5baff42b12de5f3 429 PRINTS PR00415 Aconitase family signature 131 146 4.4E-17 T 13-10-2018 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain KEGG: 00290+4.2.1.33 TOPB45_1287 debbfc1f5704af28c5baff42b12de5f3 429 PRINTS PR00415 Aconitase family signature 356 369 4.4E-17 T 13-10-2018 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain KEGG: 00290+4.2.1.33 TOPB45_1287 debbfc1f5704af28c5baff42b12de5f3 429 PRINTS PR00415 Aconitase family signature 193 206 4.4E-17 T 13-10-2018 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain KEGG: 00290+4.2.1.33 TOPB45_1287 debbfc1f5704af28c5baff42b12de5f3 429 PRINTS PR00415 Aconitase family signature 207 220 4.4E-17 T 13-10-2018 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain KEGG: 00290+4.2.1.33 TOPB45_1287 debbfc1f5704af28c5baff42b12de5f3 429 Pfam PF00330 Aconitase family (aconitate hydratase) 10 415 8.6E-88 T 13-10-2018 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain KEGG: 00290+4.2.1.33 TOPB45_1115 db8067b221359e6e982abd816a9e9bad 455 TIGRFAM TIGR01897 cas_MJ1666: CRISPR-associated protein, MJ1666 family 1 443 1.8E-46 T 13-10-2018 IPR010171 CRISPR-associated protein, MJ1666 TOPB45_1115 db8067b221359e6e982abd816a9e9bad 455 Gene3D G3DSA:3.40.50.10640 11 319 6.4E-6 T 13-10-2018 TOPB45_1115 db8067b221359e6e982abd816a9e9bad 455 SUPERFAMILY SSF160980 2 449 5.23E-41 T 13-10-2018 TOPB45_1115 db8067b221359e6e982abd816a9e9bad 455 Pfam PF09455 CRISPR-associated (Cas) DxTHG family 2 422 3.8E-28 T 13-10-2018 IPR019016 CRISPR-associated DxTHG protein TOPB45_1115 db8067b221359e6e982abd816a9e9bad 455 Gene3D G3DSA:1.10.3740.10 373 453 6.8E-10 T 13-10-2018 IPR027419 CRISPR-associated protein Csx1, C-terminal TOPB45_1239 2cb4d73fdb3fb51346c393d6b0f71c3b 184 Pfam PF11823 Protein of unknown function (DUF3343) 22 87 2.1E-16 T 13-10-2018 IPR021778 Domain of unknown function DUF3343 TOPB45_1507 11819330d6e6f532b473502113837e82 119 Gene3D G3DSA:3.40.50.2300 7 119 1.1E-19 T 13-10-2018 TOPB45_1507 11819330d6e6f532b473502113837e82 119 SUPERFAMILY SSF52172 12 117 1.57E-17 T 13-10-2018 IPR011006 CheY-like superfamily TOPB45_1507 11819330d6e6f532b473502113837e82 119 Pfam PF00072 Response regulator receiver domain 11 113 1.2E-12 T 13-10-2018 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TOPB45_1167 662a9a9da1415f8178334236791c1670 286 Hamap MF_00188 Protease HtpX [htpX]. 4 282 30.106 T 13-10-2018 IPR022919 Peptidase M48, protease HtpX, putative GO:0004222 TOPB45_1167 662a9a9da1415f8178334236791c1670 286 Gene3D G3DSA:3.30.2010.10 59 148 2.3E-32 T 13-10-2018 TOPB45_1167 662a9a9da1415f8178334236791c1670 286 Pfam PF01435 Peptidase family M48 65 281 4.9E-41 T 13-10-2018 IPR001915 Peptidase M48 GO:0004222|GO:0006508 TOPB45_1403 a997aeeb105f3f767d740bb08c22ae47 293 Gene3D G3DSA:3.90.550.10 1 246 3.1E-47 T 13-10-2018 IPR029044 Nucleotide-diphospho-sugar transferases TOPB45_1403 a997aeeb105f3f767d740bb08c22ae47 293 SUPERFAMILY SSF51161 209 286 2.04E-5 T 13-10-2018 IPR011004 Trimeric LpxA-like superfamily TOPB45_1403 a997aeeb105f3f767d740bb08c22ae47 293 SUPERFAMILY SSF53448 2 227 4.28E-45 T 13-10-2018 IPR029044 Nucleotide-diphospho-sugar transferases TOPB45_1403 a997aeeb105f3f767d740bb08c22ae47 293 Pfam PF00483 Nucleotidyl transferase 3 131 2.4E-18 T 13-10-2018 IPR005835 Nucleotidyl transferase domain GO:0009058|GO:0016779 TOPB45_0742 4176953d7679887ab332a5cb70bee732 187 PIRSF PIRSF006019 1 166 4.2E-49 T 13-10-2018 IPR016473 Deoxycytidylate deaminase GO:0004132|GO:0006220|GO:0008270 KEGG: 00240+3.5.4.12|MetaCyc: PWY-7210|Reactome: R-HSA-499943 TOPB45_0742 4176953d7679887ab332a5cb70bee732 187 ProSitePatterns PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 85 120 - T 13-10-2018 IPR016192 APOBEC/CMP deaminase, zinc-binding GO:0008270|GO:0016787 TOPB45_0742 4176953d7679887ab332a5cb70bee732 187 Gene3D G3DSA:3.40.140.10 2 175 1.3E-44 T 13-10-2018 TOPB45_0742 4176953d7679887ab332a5cb70bee732 187 SUPERFAMILY SSF53927 11 158 9.37E-37 T 13-10-2018 IPR016193 Cytidine deaminase-like GO:0003824 TOPB45_0742 4176953d7679887ab332a5cb70bee732 187 Pfam PF00383 Cytidine and deoxycytidylate deaminase zinc-binding region 9 130 9.4E-25 T 13-10-2018 IPR002125 Cytidine and deoxycytidylate deaminase domain TOPB45_0722 01892165d2ecbe89e24256950f818e68 251 Pfam PF01656 CobQ/CobB/MinD/ParA nucleotide binding domain 9 228 1.0E-13 T 13-10-2018 IPR002586 CobQ/CobB/MinD/ParA nucleotide binding domain TOPB45_0722 01892165d2ecbe89e24256950f818e68 251 Gene3D G3DSA:3.40.50.300 3 250 2.3E-45 T 13-10-2018 TOPB45_0722 01892165d2ecbe89e24256950f818e68 251 PIRSF PIRSF005647 3 251 1.0E-57 T 13-10-2018 IPR014433 Nickel insertion ATPase/GTPase (CO dehydrogenase maturation factor), CooC type TOPB45_0722 01892165d2ecbe89e24256950f818e68 251 SUPERFAMILY SSF52540 2 250 7.65E-30 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0276 32639abb2bf6157217b2f336c77eaf2c 264 Hamap MF_00361 NAD kinase [nadK]. 2 264 27.843 T 13-10-2018 IPR002504 NAD kinase GO:0003951|GO:0006741 KEGG: 00760+2.7.1.23|MetaCyc: PWY-5083|MetaCyc: PWY-7268|MetaCyc: PWY-7269|Reactome: R-HSA-196807 TOPB45_0276 32639abb2bf6157217b2f336c77eaf2c 264 Pfam PF01513 ATP-NAD kinase 41 248 2.0E-48 T 13-10-2018 IPR002504 NAD kinase GO:0003951|GO:0006741 KEGG: 00760+2.7.1.23|MetaCyc: PWY-5083|MetaCyc: PWY-7268|MetaCyc: PWY-7269|Reactome: R-HSA-196807 TOPB45_0276 32639abb2bf6157217b2f336c77eaf2c 264 SUPERFAMILY SSF111331 36 264 3.01E-69 T 13-10-2018 IPR016064 NAD kinase/diacylglycerol kinase-like domain superfamily TOPB45_0276 32639abb2bf6157217b2f336c77eaf2c 264 Gene3D G3DSA:2.60.200.30 110 241 1.7E-72 T 13-10-2018 IPR017437 ATP-NAD kinase, PpnK-type, C-terminal GO:0003951|GO:0019674 KEGG: 00760+2.7.1.23|MetaCyc: PWY-5083|MetaCyc: PWY-7268|MetaCyc: PWY-7269|Reactome: R-HSA-196807 TOPB45_0276 32639abb2bf6157217b2f336c77eaf2c 264 Gene3D G3DSA:3.40.50.10330 32 264 1.7E-72 T 13-10-2018 IPR017438 Inorganic polyphosphate/ATP-NAD kinase, N-terminal GO:0003951 TOPB45_1076 6e32fe0cd88b671eeed48ae037ca0c16 328 Gene3D G3DSA:3.90.1640.10 1 206 1.7E-44 T 13-10-2018 TOPB45_1076 6e32fe0cd88b671eeed48ae037ca0c16 328 SUPERFAMILY SSF64182 16 317 1.83E-54 T 13-10-2018 IPR038763 DHH phosphoesterase superfamily TOPB45_1076 6e32fe0cd88b671eeed48ae037ca0c16 328 Pfam PF01368 DHH family 18 164 2.3E-13 T 13-10-2018 IPR001667 DDH domain KEGG: 00190+3.6.1.1|MetaCyc: PWY-7805|MetaCyc: PWY-7807 TOPB45_1076 6e32fe0cd88b671eeed48ae037ca0c16 328 Pfam PF02272 DHHA1 domain 215 322 3.3E-13 T 13-10-2018 IPR003156 DHHA1 domain GO:0003676 KEGG: 00970+6.1.1.7|Reactome: R-HSA-379716 TOPB45_1076 6e32fe0cd88b671eeed48ae037ca0c16 328 Gene3D G3DSA:3.10.310.30 207 327 1.4E-25 T 13-10-2018 TOPB45_1555 3496d77458e48ff974ff5a3f44e283e2 273 PIRSF PIRSF038471 1 270 5.7E-57 T 13-10-2018 IPR007221 Rod shape-determining protein MreC GO:0008360 TOPB45_1555 3496d77458e48ff974ff5a3f44e283e2 273 TIGRFAM TIGR00219 mreC: rod shape-determining protein MreC 5 266 9.5E-34 T 13-10-2018 IPR007221 Rod shape-determining protein MreC GO:0008360 TOPB45_1555 3496d77458e48ff974ff5a3f44e283e2 273 Gene3D G3DSA:2.40.10.340 112 264 3.3E-39 T 13-10-2018 TOPB45_1555 3496d77458e48ff974ff5a3f44e283e2 273 Pfam PF04085 rod shape-determining protein MreC 114 265 1.3E-39 T 13-10-2018 IPR007221 Rod shape-determining protein MreC GO:0008360 TOPB45_1555 3496d77458e48ff974ff5a3f44e283e2 273 Gene3D G3DSA:2.40.10.350 176 253 3.3E-39 T 13-10-2018 TOPB45_0833 c2d427edaf985c4db5c9d09e33025d37 292 SUPERFAMILY SSF56349 2 286 2.91E-61 T 13-10-2018 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 TOPB45_0833 c2d427edaf985c4db5c9d09e33025d37 292 TIGRFAM TIGR02225 recomb_XerD: tyrosine recombinase XerD 6 292 2.3E-109 T 13-10-2018 IPR011932 Tyrosine recombinase XerD GO:0006310|GO:0009009 TOPB45_0833 c2d427edaf985c4db5c9d09e33025d37 292 Gene3D G3DSA:1.10.443.10 106 286 9.2E-70 T 13-10-2018 IPR013762 Integrase-like, catalytic domain superfamily GO:0003677|GO:0006310|GO:0015074 TOPB45_0833 c2d427edaf985c4db5c9d09e33025d37 292 Hamap MF_01808 Tyrosine recombinase XerC [xerC]. 3 292 56.267 T 13-10-2018 IPR023009 Tyrosine recombinase XerC/XerD TOPB45_0833 c2d427edaf985c4db5c9d09e33025d37 292 Pfam PF00589 Phage integrase family 106 278 3.6E-52 T 13-10-2018 IPR002104 Integrase, catalytic domain GO:0003677|GO:0006310|GO:0015074 TOPB45_0833 c2d427edaf985c4db5c9d09e33025d37 292 Pfam PF02899 Phage integrase, N-terminal SAM-like domain 5 85 1.3E-17 T 13-10-2018 IPR004107 Integrase, SAM-like, N-terminal GO:0003677|GO:0015074 TOPB45_0833 c2d427edaf985c4db5c9d09e33025d37 292 Gene3D G3DSA:1.10.150.130 2 93 3.5E-19 T 13-10-2018 IPR010998 Integrase/recombinase, N-terminal TOPB45_0543 2a83a3e4600615d9a0d9ae357b5d63a9 97 Gene3D G3DSA:4.10.520.10 2 97 1.0E-19 T 13-10-2018 IPR010992 Integration host factor (IHF)-like DNA-binding domain superfamily GO:0003677 TOPB45_0543 2a83a3e4600615d9a0d9ae357b5d63a9 97 SUPERFAMILY SSF47729 3 89 2.36E-17 T 13-10-2018 IPR010992 Integration host factor (IHF)-like DNA-binding domain superfamily GO:0003677 TOPB45_0543 2a83a3e4600615d9a0d9ae357b5d63a9 97 SMART SM00411 4 93 5.5E-11 T 13-10-2018 IPR000119 Histone-like DNA-binding protein GO:0003677 TOPB45_0543 2a83a3e4600615d9a0d9ae357b5d63a9 97 Pfam PF00216 Bacterial DNA-binding protein 5 89 1.0E-18 T 13-10-2018 IPR000119 Histone-like DNA-binding protein GO:0003677 TOPB45_1077 c49f083f70d3c818c82d02a45f208d67 113 TIGRFAM TIGR00082 rbfA: ribosome-binding factor A 2 111 4.0E-26 T 13-10-2018 IPR000238 Ribosome-binding factor A GO:0006364 TOPB45_1077 c49f083f70d3c818c82d02a45f208d67 113 Hamap MF_00003 Ribosome-binding factor A [rbfA]. 3 106 22.878 T 13-10-2018 IPR000238 Ribosome-binding factor A GO:0006364 TOPB45_1077 c49f083f70d3c818c82d02a45f208d67 113 Gene3D G3DSA:3.30.300.20 1 113 1.9E-31 T 13-10-2018 IPR015946 K homology domain-like, alpha/beta TOPB45_1077 c49f083f70d3c818c82d02a45f208d67 113 ProDom PD007327 FACTOR A RIBOSOME-BINDING PROCESSING RRNA 3D-STRUCTURE RIBOSOMAL-BINDING PRECURSOR A RBFA 7 93 2.0E-12 T 13-10-2018 IPR000238 Ribosome-binding factor A GO:0006364 TOPB45_1077 c49f083f70d3c818c82d02a45f208d67 113 SUPERFAMILY SSF89919 2 109 6.15E-27 T 13-10-2018 IPR023799 Ribosome-binding factor A domain superfamily TOPB45_1077 c49f083f70d3c818c82d02a45f208d67 113 Pfam PF02033 Ribosome-binding factor A 4 106 4.2E-28 T 13-10-2018 IPR000238 Ribosome-binding factor A GO:0006364 TOPB45_0100 ef6648a42c380c2abf76d541427cf6d9 117 Gene3D G3DSA:1.20.58.1610 1 117 5.2E-44 T 13-10-2018 IPR038430 NADH:ubiquinone oxidoreductase, subunit 3 superfamily Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_0100 ef6648a42c380c2abf76d541427cf6d9 117 Hamap MF_01394 NAD(P)H-quinone oxidoreductase subunit 3, chloroplastic [ndhC]. 1 117 19.312 T 13-10-2018 IPR023043 NAD(P)H-quinone oxidoreductase subunit 3, bacterial/plastid GO:0016651|GO:0055114 TOPB45_0100 ef6648a42c380c2abf76d541427cf6d9 117 Pfam PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 20 116 9.4E-39 T 13-10-2018 IPR000440 NADH:ubiquinone/plastoquinone oxidoreductase, chain 3 GO:0008137|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_0438 c6b6f3163fefedac5cecba15c8f5848a 321 Gene3D G3DSA:2.40.50.100 52 226 2.1E-56 T 13-10-2018 TOPB45_0438 c6b6f3163fefedac5cecba15c8f5848a 321 Gene3D G3DSA:1.10.287.470 86 191 2.1E-56 T 13-10-2018 TOPB45_0438 c6b6f3163fefedac5cecba15c8f5848a 321 SUPERFAMILY SSF111369 52 311 4.97E-20 T 13-10-2018 TOPB45_0438 c6b6f3163fefedac5cecba15c8f5848a 321 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion 52 306 1.0E-25 T 13-10-2018 IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain TOPB45_0438 c6b6f3163fefedac5cecba15c8f5848a 321 Gene3D G3DSA:2.40.30.170 227 313 2.1E-56 T 13-10-2018 TOPB45_0438 c6b6f3163fefedac5cecba15c8f5848a 321 TIGRFAM TIGR01730 RND_mfp: efflux transporter, RND family, MFP subunit 52 313 1.6E-30 T 13-10-2018 IPR006143 RND efflux pump, membrane fusion protein GO:0005215|GO:0016020|GO:0055085 TOPB45_0342 ed716f9ee3b823e99680f9e2c7c0cca0 279 SUPERFAMILY SSF53448 8 265 8.26E-47 T 13-10-2018 IPR029044 Nucleotide-diphospho-sugar transferases TOPB45_0342 ed716f9ee3b823e99680f9e2c7c0cca0 279 Pfam PF00535 Glycosyl transferase family 2 8 192 2.8E-14 T 13-10-2018 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 TOPB45_0342 ed716f9ee3b823e99680f9e2c7c0cca0 279 Gene3D G3DSA:3.90.550.10 4 240 3.1E-38 T 13-10-2018 IPR029044 Nucleotide-diphospho-sugar transferases TOPB45_0444 a504ac91c61c8e608d777eae03d445c8 214 SUPERFAMILY SSF53254 10 190 7.5E-38 T 13-10-2018 IPR029033 Histidine phosphatase superfamily TOPB45_0444 a504ac91c61c8e608d777eae03d445c8 214 Pfam PF00300 Histidine phosphatase superfamily (branch 1) 11 199 8.5E-43 T 13-10-2018 IPR013078 Histidine phosphatase superfamily, clade-1 TOPB45_0444 a504ac91c61c8e608d777eae03d445c8 214 SMART SM00855 10 160 7.3E-8 T 13-10-2018 IPR013078 Histidine phosphatase superfamily, clade-1 TOPB45_0444 a504ac91c61c8e608d777eae03d445c8 214 Gene3D G3DSA:3.40.50.1240 9 207 1.1E-43 T 13-10-2018 IPR029033 Histidine phosphatase superfamily TOPB45_1089 0011caf81eb468c6161e82eaa2674faf 2281 SUPERFAMILY SSF103515 2003 2281 2.62E-23 T 13-10-2018 IPR036709 Autotransporter beta-domain superfamily TOPB45_1089 0011caf81eb468c6161e82eaa2674faf 2281 SMART SM00869 2005 2271 5.1E-14 T 13-10-2018 IPR005546 Autotransporter beta-domain TOPB45_1223 ea60ddd732f70d7959db596ca386a973 277 Pfam PF09704 CRISPR-associated protein (Cas_Cas5) 4 200 2.8E-19 T 13-10-2018 IPR021124 CRISPR-associated protein, Cas5 GO:0043571 TOPB45_1223 ea60ddd732f70d7959db596ca386a973 277 Gene3D G3DSA:3.30.70.2660 2 164 9.8E-8 T 13-10-2018 TOPB45_1223 ea60ddd732f70d7959db596ca386a973 277 TIGRFAM TIGR02593 CRISPR_cas5: CRISPR-associated protein Cas5 3 45 4.6E-15 T 13-10-2018 IPR013422 CRISPR-associated protein Cas5, N-terminal TOPB45_1223 ea60ddd732f70d7959db596ca386a973 277 TIGRFAM TIGR01895 cas_Cas5t: CRISPR-associated protein Cas5, subtype I-B/TNEAP 1 263 6.4E-38 T 13-10-2018 IPR013337 CRISPR-associated protein Cas5, Tneap type TOPB45_0205 4e598850b3505cc7a6bf8dc7786a1d6a 282 SUPERFAMILY SSF52374 1 279 5.63E-110 T 13-10-2018 TOPB45_0205 4e598850b3505cc7a6bf8dc7786a1d6a 282 Gene3D G3DSA:3.30.1300.10 178 277 1.1E-33 T 13-10-2018 TOPB45_0205 4e598850b3505cc7a6bf8dc7786a1d6a 282 Pfam PF02569 Pantoate-beta-alanine ligase 3 277 3.5E-106 T 13-10-2018 IPR003721 Pantoate-beta-alanine ligase GO:0004592|GO:0015940 KEGG: 00410+6.3.2.1|KEGG: 00770+6.3.2.1 TOPB45_0205 4e598850b3505cc7a6bf8dc7786a1d6a 282 Hamap MF_00158 Pantothenate synthetase [panC]. 2 279 40.846 T 13-10-2018 IPR003721 Pantoate-beta-alanine ligase GO:0004592|GO:0015940 KEGG: 00410+6.3.2.1|KEGG: 00770+6.3.2.1 TOPB45_0205 4e598850b3505cc7a6bf8dc7786a1d6a 282 Gene3D G3DSA:3.40.50.620 1 177 1.7E-78 T 13-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TOPB45_0205 4e598850b3505cc7a6bf8dc7786a1d6a 282 TIGRFAM TIGR00018 panC: pantoate--beta-alanine ligase 1 280 5.3E-106 T 13-10-2018 IPR003721 Pantoate-beta-alanine ligase GO:0004592|GO:0015940 KEGG: 00410+6.3.2.1|KEGG: 00770+6.3.2.1 TOPB45_0205 4e598850b3505cc7a6bf8dc7786a1d6a 282 TIGRFAM TIGR00125 cyt_tran_rel: cytidyltransferase-like domain 24 86 2.4E-11 T 13-10-2018 IPR004821 Cytidyltransferase-like domain GO:0003824|GO:0009058 TOPB45_0640 ec6937e65c663d4fb81c27f71c3d8f2c 208 ProSitePatterns PS00379 CDP-alcohol phosphatidyltransferases signature. 68 90 - T 13-10-2018 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 TOPB45_0640 ec6937e65c663d4fb81c27f71c3d8f2c 208 Gene3D G3DSA:1.20.120.1760 6 199 9.7E-32 T 13-10-2018 TOPB45_0640 ec6937e65c663d4fb81c27f71c3d8f2c 208 Pfam PF01066 CDP-alcohol phosphatidyltransferase 28 90 2.2E-11 T 13-10-2018 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 TOPB45_1143 d962b382172266bca78817bc5bd4b931 221 Pfam PF01135 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) 15 215 4.0E-64 T 13-10-2018 TOPB45_1143 d962b382172266bca78817bc5bd4b931 221 SUPERFAMILY SSF53335 14 215 1.67E-49 T 13-10-2018 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TOPB45_1143 d962b382172266bca78817bc5bd4b931 221 TIGRFAM TIGR00080 pimt: protein-L-isoaspartate O-methyltransferase 15 216 4.7E-70 T 13-10-2018 IPR000682 Protein-L-isoaspartate(D-aspartate) O-methyltransferase GO:0004719|GO:0006464 TOPB45_1143 d962b382172266bca78817bc5bd4b931 221 ProSitePatterns PS01279 Protein-L-isoaspartate(D-aspartate) O-methyltransferase signature. 140 155 - T 13-10-2018 IPR000682 Protein-L-isoaspartate(D-aspartate) O-methyltransferase GO:0004719|GO:0006464 TOPB45_1143 d962b382172266bca78817bc5bd4b931 221 Gene3D G3DSA:3.40.50.150 2 221 2.2E-77 T 13-10-2018 TOPB45_1143 d962b382172266bca78817bc5bd4b931 221 Hamap MF_00090 Protein-L-isoaspartate O-methyltransferase [pcm]. 6 219 39.655 T 13-10-2018 IPR000682 Protein-L-isoaspartate(D-aspartate) O-methyltransferase GO:0004719|GO:0006464 TOPB45_0880 aa898b31bd3c061d9b78a61cd3a6390f 123 PRINTS PR00124 ATP synthase C subunit signature 81 106 5.7E-18 T 13-10-2018 IPR000454 ATP synthase, F0 complex, subunit C GO:0015078|GO:0015986|GO:0045263 Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_0880 aa898b31bd3c061d9b78a61cd3a6390f 123 PRINTS PR00124 ATP synthase C subunit signature 64 79 5.7E-18 T 13-10-2018 IPR000454 ATP synthase, F0 complex, subunit C GO:0015078|GO:0015986|GO:0045263 Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_0880 aa898b31bd3c061d9b78a61cd3a6390f 123 PRINTS PR00124 ATP synthase C subunit signature 43 62 5.7E-18 T 13-10-2018 IPR000454 ATP synthase, F0 complex, subunit C GO:0015078|GO:0015986|GO:0045263 Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_0880 aa898b31bd3c061d9b78a61cd3a6390f 123 ProSitePatterns PS00605 ATP synthase c subunit signature. 71 92 - T 13-10-2018 IPR020537 ATP synthase, F0 complex, subunit C, DCCD-binding site Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_0880 aa898b31bd3c061d9b78a61cd3a6390f 123 Pfam PF00137 ATP synthase subunit C 42 105 5.1E-16 T 13-10-2018 IPR002379 V-ATPase proteolipid subunit C-like domain GO:0015078|GO:0015991|GO:0033177 TOPB45_0880 aa898b31bd3c061d9b78a61cd3a6390f 123 TIGRFAM TIGR01260 ATP_synt_c: ATP synthase F0, C subunit 51 108 2.5E-17 T 13-10-2018 IPR005953 ATP synthase, F0 complex, subunit C, bacterial/chloroplast GO:0015078|GO:0015986|GO:0045263 TOPB45_0880 aa898b31bd3c061d9b78a61cd3a6390f 123 Gene3D G3DSA:1.20.20.10 25 109 1.1E-27 T 13-10-2018 IPR038662 F1F0 ATP synthase subunit C superfamily Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_0880 aa898b31bd3c061d9b78a61cd3a6390f 123 SUPERFAMILY SSF81333 37 110 9.02E-20 T 13-10-2018 IPR035921 F/V-ATP synthase subunit C superfamily TOPB45_0880 aa898b31bd3c061d9b78a61cd3a6390f 123 Hamap MF_01396 ATP synthase subunit c [atpH]. 41 106 15.516 T 13-10-2018 IPR000454 ATP synthase, F0 complex, subunit C GO:0015078|GO:0015986|GO:0045263 Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_0207 ece9cdccc2f1168f4e2fa442bc57e96e 130 SUPERFAMILY SSF111038 5 128 4.19E-43 T 13-10-2018 IPR035917 YjbQ-like superfamily TOPB45_0207 ece9cdccc2f1168f4e2fa442bc57e96e 130 PIRSF PIRSF004681 1 130 2.8E-38 T 13-10-2018 IPR001602 Uncharacterised protein family UPF0047 TOPB45_0207 ece9cdccc2f1168f4e2fa442bc57e96e 130 TIGRFAM TIGR00149 TIGR00149_YjbQ: secondary thiamine-phosphate synthase enzyme 5 127 4.0E-48 T 13-10-2018 IPR001602 Uncharacterised protein family UPF0047 TOPB45_0207 ece9cdccc2f1168f4e2fa442bc57e96e 130 Pfam PF01894 Uncharacterised protein family UPF0047 18 126 4.9E-37 T 13-10-2018 IPR001602 Uncharacterised protein family UPF0047 TOPB45_0207 ece9cdccc2f1168f4e2fa442bc57e96e 130 Gene3D G3DSA:2.60.120.460 1 130 2.4E-46 T 13-10-2018 IPR035917 YjbQ-like superfamily TOPB45_0207 ece9cdccc2f1168f4e2fa442bc57e96e 130 ProSitePatterns PS01314 Uncharacterized protein family UPF0047 signature. 92 110 - T 13-10-2018 IPR001602 Uncharacterised protein family UPF0047 TOPB45_0605 36c462819988113b2a2111a8fa3b2803 194 Pfam PF02834 LigT like Phosphoesterase 8 92 3.7E-17 T 13-10-2018 IPR014051 Phosphoesterase, HXTX TOPB45_0605 36c462819988113b2a2111a8fa3b2803 194 Pfam PF02834 LigT like Phosphoesterase 98 181 1.6E-8 T 13-10-2018 IPR014051 Phosphoesterase, HXTX TOPB45_0605 36c462819988113b2a2111a8fa3b2803 194 SUPERFAMILY SSF55144 3 191 2.44E-37 T 13-10-2018 IPR009097 Cyclic phosphodiesterase TOPB45_0605 36c462819988113b2a2111a8fa3b2803 194 Gene3D G3DSA:3.90.1140.10 2 191 8.1E-52 T 13-10-2018 TOPB45_0605 36c462819988113b2a2111a8fa3b2803 194 TIGRFAM TIGR02258 2_5_ligase: 2'-5' RNA ligase 2 189 4.8E-45 T 13-10-2018 IPR004175 RNA 2',3'-cyclic phosphodiesterase GO:0004113|GO:0008664 TOPB45_0605 36c462819988113b2a2111a8fa3b2803 194 Hamap MF_01940 RNA 2',3'-cyclic phosphodiesterase [thpR]. 2 189 25.8 T 13-10-2018 IPR004175 RNA 2',3'-cyclic phosphodiesterase GO:0004113|GO:0008664 TOPB45_0095 2b5271ace9fe710638187e71fc1eab9c 180 Pfam PF12838 4Fe-4S dicluster domain 62 116 1.0E-10 T 13-10-2018 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain TOPB45_0095 2b5271ace9fe710638187e71fc1eab9c 180 SUPERFAMILY SSF54862 60 152 1.67E-23 T 13-10-2018 TOPB45_0095 2b5271ace9fe710638187e71fc1eab9c 180 Gene3D G3DSA:3.30.70.3270 34 163 2.4E-33 T 13-10-2018 TOPB45_0095 2b5271ace9fe710638187e71fc1eab9c 180 Hamap MF_01351 NAD(P)H-quinone oxidoreductase subunit I, chloroplastic [ndhI]. 6 146 26.216 T 13-10-2018 IPR010226 NADH-quinone oxidoreductase, chain I GO:0016020|GO:0016651|GO:0051539|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_0095 2b5271ace9fe710638187e71fc1eab9c 180 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 102 113 - T 13-10-2018 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site TOPB45_0095 2b5271ace9fe710638187e71fc1eab9c 180 TIGRFAM TIGR01971 NuoI: NADH-quinone oxidoreductase, chain I 16 140 1.3E-36 T 13-10-2018 IPR010226 NADH-quinone oxidoreductase, chain I GO:0016020|GO:0016651|GO:0051539|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_1019 4fbcd3569ae7068cf850d49603ab1c90 249 Hamap MF_01139 Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) [uppS]. 17 245 39.671 T 13-10-2018 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 TOPB45_1019 4fbcd3569ae7068cf850d49603ab1c90 249 SUPERFAMILY SSF64005 12 239 1.83E-84 T 13-10-2018 IPR036424 Decaprenyl diphosphate synthase-like superfamily GO:0016765 Reactome: R-HSA-446199 TOPB45_1019 4fbcd3569ae7068cf850d49603ab1c90 249 Pfam PF01255 Putative undecaprenyl diphosphate synthase 24 244 1.2E-78 T 13-10-2018 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 TOPB45_1019 4fbcd3569ae7068cf850d49603ab1c90 249 Gene3D G3DSA:3.40.1180.10 3 245 1.1E-94 T 13-10-2018 IPR036424 Decaprenyl diphosphate synthase-like superfamily GO:0016765 Reactome: R-HSA-446199 TOPB45_1019 4fbcd3569ae7068cf850d49603ab1c90 249 TIGRFAM TIGR00055 uppS: di-trans,poly-cis-decaprenylcistransferase 17 244 6.1E-88 T 13-10-2018 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 TOPB45_1521 e0bd82e43acf98b50057110fe4e6f578 192 Pfam PF00081 Iron/manganese superoxide dismutases, alpha-hairpin domain 24 80 1.3E-4 T 13-10-2018 IPR019831 Manganese/iron superoxide dismutase, N-terminal GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854|Reactome: R-HSA-2151201|Reactome: R-HSA-3299685|Reactome: R-HSA-8862803|Reactome: R-HSA-8950505 TOPB45_1521 e0bd82e43acf98b50057110fe4e6f578 192 Gene3D G3DSA:2.40.500.20 82 192 6.7E-32 T 13-10-2018 IPR036314 Manganese/iron superoxide dismutase, C-terminal domain superfamily MetaCyc: PWY-6854|Reactome: R-HSA-2151201|Reactome: R-HSA-3299685|Reactome: R-HSA-8862803|Reactome: R-HSA-8950505 TOPB45_1521 e0bd82e43acf98b50057110fe4e6f578 192 Gene3D G3DSA:1.10.287.990 17 81 1.9E-7 T 13-10-2018 IPR036324 Manganese/iron superoxide dismutase, N-terminal domain superfamily MetaCyc: PWY-6854|Reactome: R-HSA-2151201|Reactome: R-HSA-3299685|Reactome: R-HSA-8862803|Reactome: R-HSA-8950505 TOPB45_1521 e0bd82e43acf98b50057110fe4e6f578 192 PIRSF PIRSF000349 3 192 2.8E-44 T 13-10-2018 IPR001189 Manganese/iron superoxide dismutase GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854|Reactome: R-HSA-2151201|Reactome: R-HSA-3299685|Reactome: R-HSA-8862803|Reactome: R-HSA-8950505 TOPB45_1521 e0bd82e43acf98b50057110fe4e6f578 192 SUPERFAMILY SSF54719 89 190 3.8E-34 T 13-10-2018 IPR036314 Manganese/iron superoxide dismutase, C-terminal domain superfamily MetaCyc: PWY-6854|Reactome: R-HSA-2151201|Reactome: R-HSA-3299685|Reactome: R-HSA-8862803|Reactome: R-HSA-8950505 TOPB45_1521 e0bd82e43acf98b50057110fe4e6f578 192 Pfam PF02777 Iron/manganese superoxide dismutases, C-terminal domain 90 189 7.3E-26 T 13-10-2018 IPR019832 Manganese/iron superoxide dismutase, C-terminal GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854|Reactome: R-HSA-2151201|Reactome: R-HSA-3299685|Reactome: R-HSA-8862803|Reactome: R-HSA-8950505 TOPB45_1521 e0bd82e43acf98b50057110fe4e6f578 192 SUPERFAMILY SSF46609 12 81 2.9E-11 T 13-10-2018 IPR036324 Manganese/iron superoxide dismutase, N-terminal domain superfamily MetaCyc: PWY-6854|Reactome: R-HSA-2151201|Reactome: R-HSA-3299685|Reactome: R-HSA-8862803|Reactome: R-HSA-8950505 TOPB45_0347 1542edc7fb21980a7776d2e2ac26c61c 327 Pfam PF00535 Glycosyl transferase family 2 76 179 2.6E-6 T 13-10-2018 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 TOPB45_0347 1542edc7fb21980a7776d2e2ac26c61c 327 SUPERFAMILY SSF53448 2 307 7.36E-29 T 13-10-2018 IPR029044 Nucleotide-diphospho-sugar transferases TOPB45_0347 1542edc7fb21980a7776d2e2ac26c61c 327 Gene3D G3DSA:3.90.550.10 57 262 1.1E-24 T 13-10-2018 IPR029044 Nucleotide-diphospho-sugar transferases TOPB45_0541 53e46c056cbd1f7ba6e5ca019ea3af60 133 TIGRFAM TIGR00320 dfx_rbo: desulfoferrodoxin 1 125 9.3E-60 T 13-10-2018 IPR004793 Desulfoferrodoxin GO:0005506|GO:0019430 TOPB45_0541 53e46c056cbd1f7ba6e5ca019ea3af60 133 Pfam PF01880 Desulfoferrodoxin 42 125 1.3E-24 T 13-10-2018 IPR002742 Desulfoferrodoxin, ferrous iron-binding domain GO:0005506|GO:0016491|GO:0055114 TOPB45_0541 53e46c056cbd1f7ba6e5ca019ea3af60 133 TIGRFAM TIGR00332 neela_ferrous: desulfoferrodoxin ferrous iron-binding domain 43 127 1.4E-24 T 13-10-2018 IPR002742 Desulfoferrodoxin, ferrous iron-binding domain GO:0005506|GO:0016491|GO:0055114 TOPB45_0541 53e46c056cbd1f7ba6e5ca019ea3af60 133 Gene3D G3DSA:2.20.28.100 1 38 2.8E-15 T 13-10-2018 IPR038094 Desulforodoxin domain superfamily TOPB45_0541 53e46c056cbd1f7ba6e5ca019ea3af60 133 SUPERFAMILY SSF57802 4 37 1.65E-11 T 13-10-2018 TOPB45_0541 53e46c056cbd1f7ba6e5ca019ea3af60 133 TIGRFAM TIGR00319 desulf_FeS4: desulfoferrodoxin FeS4 iron-binding domain 1 34 1.9E-17 T 13-10-2018 IPR004462 Desulforodoxin domain GO:0005506 TOPB45_0541 53e46c056cbd1f7ba6e5ca019ea3af60 133 Pfam PF06397 Desulfoferrodoxin, N-terminal domain 3 37 1.1E-18 T 13-10-2018 IPR004462 Desulforodoxin domain GO:0005506 TOPB45_0541 53e46c056cbd1f7ba6e5ca019ea3af60 133 SUPERFAMILY SSF49367 34 127 4.71E-34 T 13-10-2018 IPR036073 Desulfoferrodoxin, ferrous iron-binding domain superfamily GO:0005506|GO:0016491|GO:0055114 TOPB45_0541 53e46c056cbd1f7ba6e5ca019ea3af60 133 Gene3D G3DSA:2.60.40.730 40 127 8.1E-34 T 13-10-2018 IPR036073 Desulfoferrodoxin, ferrous iron-binding domain superfamily GO:0005506|GO:0016491|GO:0055114 TOPB45_0161 6e9480950f93337d8de5983b41a7b2cf 268 Pfam PF01551 Peptidase family M23 167 261 1.6E-34 T 13-10-2018 IPR016047 Peptidase M23 TOPB45_0161 6e9480950f93337d8de5983b41a7b2cf 268 SUPERFAMILY SSF51261 31 265 1.57E-55 T 13-10-2018 IPR011055 Duplicated hybrid motif TOPB45_0161 6e9480950f93337d8de5983b41a7b2cf 268 Gene3D G3DSA:2.70.70.10 115 267 2.0E-50 T 13-10-2018 IPR011055 Duplicated hybrid motif TOPB45_0135 e3c68cea911d00be8c40f3b8fb8334fd 252 SUPERFAMILY SSF159713 5 240 4.32E-42 T 13-10-2018 TOPB45_0135 e3c68cea911d00be8c40f3b8fb8334fd 252 Pfam PF13938 Putative heavy-metal chelation 17 94 5.9E-19 T 13-10-2018 IPR025251 Domain of unknown function DUF4213 TOPB45_0135 e3c68cea911d00be8c40f3b8fb8334fd 252 Gene3D G3DSA:3.30.390.100 18 223 4.3E-22 T 13-10-2018 TOPB45_0135 e3c68cea911d00be8c40f3b8fb8334fd 252 Gene3D G3DSA:3.40.50.11590 108 217 4.3E-22 T 13-10-2018 TOPB45_0135 e3c68cea911d00be8c40f3b8fb8334fd 252 Pfam PF04016 Putative heavy-metal chelation 111 242 9.3E-27 T 13-10-2018 IPR007161 Putative heavy-metal chelation domain TOPB45_0014 42ce222cec3773d73f305ed8c8262d72 151 Gene3D G3DSA:3.40.1400.10 1 145 2.7E-63 T 13-10-2018 IPR036569 Sugar-phosphate isomerase, RpiB/LacA/LacB superfamily GO:0005975|GO:0016853 KEGG: 00052+5.3.1.26 TOPB45_0014 42ce222cec3773d73f305ed8c8262d72 151 TIGRFAM TIGR00689 rpiB_lacA_lacB: sugar-phosphate isomerase, RpiB/LacA/LacB family 5 146 5.6E-60 T 13-10-2018 IPR003500 Sugar-phosphate isomerase, RpiB/LacA/LacB family GO:0005975|GO:0016853 KEGG: 00052+5.3.1.26 TOPB45_0014 42ce222cec3773d73f305ed8c8262d72 151 Pfam PF02502 Ribose/Galactose Isomerase 5 141 3.8E-59 T 13-10-2018 IPR003500 Sugar-phosphate isomerase, RpiB/LacA/LacB family GO:0005975|GO:0016853 KEGG: 00052+5.3.1.26 TOPB45_0014 42ce222cec3773d73f305ed8c8262d72 151 PIRSF PIRSF005384 3 149 7.2E-60 T 13-10-2018 IPR003500 Sugar-phosphate isomerase, RpiB/LacA/LacB family GO:0005975|GO:0016853 KEGG: 00052+5.3.1.26 TOPB45_0014 42ce222cec3773d73f305ed8c8262d72 151 SUPERFAMILY SSF89623 4 145 5.76E-59 T 13-10-2018 IPR036569 Sugar-phosphate isomerase, RpiB/LacA/LacB superfamily GO:0005975|GO:0016853 KEGG: 00052+5.3.1.26 TOPB45_0014 42ce222cec3773d73f305ed8c8262d72 151 TIGRFAM TIGR01120 rpiB: ribose 5-phosphate isomerase B 5 144 1.1E-58 T 13-10-2018 IPR004785 Ribose 5-phosphate isomerase B GO:0004751|GO:0006098 TOPB45_1298 9e6e27eaf6273044ad2883c4a53a3ec8 383 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 7 118 1.0E-29 T 13-10-2018 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0016627|GO:0050660|GO:0055114 TOPB45_1298 9e6e27eaf6273044ad2883c4a53a3ec8 383 ProSitePatterns PS00072 Acyl-CoA dehydrogenases signature 1. 124 136 - T 13-10-2018 IPR006089 Acyl-CoA dehydrogenase, conserved site GO:0003995|GO:0055114 TOPB45_1298 9e6e27eaf6273044ad2883c4a53a3ec8 383 ProSitePatterns PS00073 Acyl-CoA dehydrogenases signature 2. 337 356 - T 13-10-2018 IPR006089 Acyl-CoA dehydrogenase, conserved site GO:0003995|GO:0055114 TOPB45_1298 9e6e27eaf6273044ad2883c4a53a3ec8 383 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 229 378 1.7E-47 T 13-10-2018 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 TOPB45_1298 9e6e27eaf6273044ad2883c4a53a3ec8 383 Gene3D G3DSA:1.10.540.10 1 119 4.0E-34 T 13-10-2018 IPR037069 Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily GO:0016627|GO:0050660|GO:0055114 TOPB45_1298 9e6e27eaf6273044ad2883c4a53a3ec8 383 PIRSF PIRSF016578 8 381 4.6E-17 T 13-10-2018 TOPB45_1298 9e6e27eaf6273044ad2883c4a53a3ec8 383 SUPERFAMILY SSF56645 3 240 7.59E-82 T 13-10-2018 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily GO:0016627|GO:0055114 TOPB45_1298 9e6e27eaf6273044ad2883c4a53a3ec8 383 Gene3D G3DSA:1.20.140.10 234 383 6.7E-54 T 13-10-2018 TOPB45_1298 9e6e27eaf6273044ad2883c4a53a3ec8 383 SUPERFAMILY SSF47203 227 382 4.83E-56 T 13-10-2018 IPR036250 Acyl-CoA dehydrogenase-like, C-terminal GO:0016627|GO:0055114 TOPB45_1298 9e6e27eaf6273044ad2883c4a53a3ec8 383 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 122 217 5.6E-27 T 13-10-2018 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0016627|GO:0055114 TOPB45_1298 9e6e27eaf6273044ad2883c4a53a3ec8 383 Gene3D G3DSA:2.40.110.10 121 233 3.2E-42 T 13-10-2018 TOPB45_1582 c2f5d3a7a1820c1ac317a7198e47b57c 493 Pfam PF14010 Phosphoenolpyruvate carboxylase 3 493 1.2E-188 T 13-10-2018 IPR007566 Phosphoenolpyruvate carboxylase, archaeal-type GO:0006099|GO:0008964|GO:0015977 KEGG: 00620+4.1.1.31|KEGG: 00680+4.1.1.31|KEGG: 00710+4.1.1.31|KEGG: 00720+4.1.1.31|MetaCyc: PWY-1622|MetaCyc: PWY-241|MetaCyc: PWY-5913|MetaCyc: PWY-6142|MetaCyc: PWY-6146|MetaCyc: PWY-6549|MetaCyc: PWY-7115|MetaCyc: PWY-7117|MetaCyc: PWY-7124 TOPB45_1582 c2f5d3a7a1820c1ac317a7198e47b57c 493 PIRSF PIRSF006677 1 493 9.9E-188 T 13-10-2018 IPR007566 Phosphoenolpyruvate carboxylase, archaeal-type GO:0006099|GO:0008964|GO:0015977 KEGG: 00620+4.1.1.31|KEGG: 00680+4.1.1.31|KEGG: 00710+4.1.1.31|KEGG: 00720+4.1.1.31|MetaCyc: PWY-1622|MetaCyc: PWY-241|MetaCyc: PWY-5913|MetaCyc: PWY-6142|MetaCyc: PWY-6146|MetaCyc: PWY-6549|MetaCyc: PWY-7115|MetaCyc: PWY-7117|MetaCyc: PWY-7124 TOPB45_1582 c2f5d3a7a1820c1ac317a7198e47b57c 493 TIGRFAM TIGR02751 PEPCase_arch: phosphoenolpyruvate carboxylase 3 493 4.0E-188 T 13-10-2018 IPR007566 Phosphoenolpyruvate carboxylase, archaeal-type GO:0006099|GO:0008964|GO:0015977 KEGG: 00620+4.1.1.31|KEGG: 00680+4.1.1.31|KEGG: 00710+4.1.1.31|KEGG: 00720+4.1.1.31|MetaCyc: PWY-1622|MetaCyc: PWY-241|MetaCyc: PWY-5913|MetaCyc: PWY-6142|MetaCyc: PWY-6146|MetaCyc: PWY-6549|MetaCyc: PWY-7115|MetaCyc: PWY-7117|MetaCyc: PWY-7124 TOPB45_1582 c2f5d3a7a1820c1ac317a7198e47b57c 493 Hamap MF_01904 Phosphoenolpyruvate carboxylase [ppcA]. 2 493 39.023 T 13-10-2018 IPR007566 Phosphoenolpyruvate carboxylase, archaeal-type GO:0006099|GO:0008964|GO:0015977 KEGG: 00620+4.1.1.31|KEGG: 00680+4.1.1.31|KEGG: 00710+4.1.1.31|KEGG: 00720+4.1.1.31|MetaCyc: PWY-1622|MetaCyc: PWY-241|MetaCyc: PWY-5913|MetaCyc: PWY-6142|MetaCyc: PWY-6146|MetaCyc: PWY-6549|MetaCyc: PWY-7115|MetaCyc: PWY-7117|MetaCyc: PWY-7124 TOPB45_1582 c2f5d3a7a1820c1ac317a7198e47b57c 493 SUPERFAMILY SSF51621 80 426 2.93E-40 T 13-10-2018 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily GO:0003824 TOPB45_1527 f8b9fc218a2e974a410708080b9cfacd 215 Gene3D G3DSA:3.30.70.1070 139 208 2.5E-15 T 13-10-2018 IPR036680 Sporulation-like domain superfamily GO:0042834 TOPB45_1527 f8b9fc218a2e974a410708080b9cfacd 215 Pfam PF05036 Sporulation related domain 139 201 5.1E-15 T 13-10-2018 IPR007730 Sporulation-like domain GO:0042834 TOPB45_1527 f8b9fc218a2e974a410708080b9cfacd 215 SUPERFAMILY SSF110997 138 210 1.18E-12 T 13-10-2018 IPR036680 Sporulation-like domain superfamily GO:0042834 TOPB45_1256 b87866f44a9dc8dd64f4dad6f5678a6b 254 Gene3D G3DSA:3.40.50.620 7 254 8.7E-89 T 13-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TOPB45_1256 b87866f44a9dc8dd64f4dad6f5678a6b 254 TIGRFAM TIGR00552 nadE: NAD+ synthetase 9 249 5.9E-82 T 13-10-2018 IPR003694 NAD(+) synthetase GO:0003952|GO:0005524|GO:0009435 KEGG: 00760+6.3.1.5|Reactome: R-HSA-196807 TOPB45_1256 b87866f44a9dc8dd64f4dad6f5678a6b 254 Pfam PF02540 NAD synthase 9 249 5.7E-87 T 13-10-2018 IPR022310 NAD/GMP synthase TOPB45_1256 b87866f44a9dc8dd64f4dad6f5678a6b 254 SUPERFAMILY SSF52402 3 249 6.4E-75 T 13-10-2018 TOPB45_1256 b87866f44a9dc8dd64f4dad6f5678a6b 254 Hamap MF_00193 NH(3)-dependent NAD(+) synthetase [nadE]. 5 252 48.064 T 13-10-2018 IPR022926 NH(3)-dependent NAD(+) synthetase GO:0008795|GO:0009435 KEGG: 00760+6.3.1.5 TOPB45_1532 b01d1b35f07658e1bc7a18900b38fe17 315 Pfam PF04166 Pyridoxal phosphate biosynthetic protein PdxA 38 308 4.7E-99 T 13-10-2018 IPR005255 PdxA family GO:0051287|GO:0055114 KEGG: 00750+1.1.1.262 TOPB45_1532 b01d1b35f07658e1bc7a18900b38fe17 315 TIGRFAM TIGR00557 pdxA: 4-hydroxythreonine-4-phosphate dehydrogenase PdxA 5 312 7.7E-105 T 13-10-2018 IPR005255 PdxA family GO:0051287|GO:0055114 KEGG: 00750+1.1.1.262 TOPB45_1532 b01d1b35f07658e1bc7a18900b38fe17 315 Gene3D G3DSA:3.40.718.10 1 314 3.7E-117 T 13-10-2018 TOPB45_1532 b01d1b35f07658e1bc7a18900b38fe17 315 SUPERFAMILY SSF53659 5 314 8.92E-98 T 13-10-2018 TOPB45_1035 e893c9add0857885f3b83bc399d1093e 113 Gene3D G3DSA:2.60.120.10 3 109 5.4E-22 T 13-10-2018 IPR014710 RmlC-like jelly roll fold TOPB45_1035 e893c9add0857885f3b83bc399d1093e 113 SUPERFAMILY SSF51182 16 111 2.72E-22 T 13-10-2018 IPR011051 RmlC-like cupin domain superfamily TOPB45_1035 e893c9add0857885f3b83bc399d1093e 113 Pfam PF07883 Cupin domain 39 107 1.5E-15 T 13-10-2018 IPR013096 Cupin 2, conserved barrel TOPB45_0425 2bdb03b94ea4f3434eddac7064394ab8 421 Gene3D G3DSA:3.40.309.10 230 378 9.8E-170 T 13-10-2018 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0016491|GO:0016620|GO:0055114 TOPB45_0425 2bdb03b94ea4f3434eddac7064394ab8 421 ProSitePatterns PS01223 Gamma-glutamyl phosphate reductase signature. 327 348 - T 13-10-2018 IPR020593 Gamma-glutamyl phosphate reductase GPR, conserved site GO:0004350|GO:0006561|GO:0055114 KEGG: 00330+1.2.1.41|KEGG: 00332+1.2.1.41|MetaCyc: PWY-3341|MetaCyc: PWY-6922|Reactome: R-HSA-70614 TOPB45_0425 2bdb03b94ea4f3434eddac7064394ab8 421 Hamap MF_00412 Gamma-glutamyl phosphate reductase [proA]. 9 420 42.348 T 13-10-2018 IPR000965 GPR domain GO:0004350|GO:0006561|GO:0055114 KEGG: 00330+1.2.1.41|KEGG: 00332+1.2.1.41|MetaCyc: PWY-3341|MetaCyc: PWY-6922|Reactome: R-HSA-70614 TOPB45_0425 2bdb03b94ea4f3434eddac7064394ab8 421 Gene3D G3DSA:3.40.605.10 22 415 9.8E-170 T 13-10-2018 IPR016162 Aldehyde dehydrogenase, N-terminal GO:0016491|GO:0055114 TOPB45_0425 2bdb03b94ea4f3434eddac7064394ab8 421 SUPERFAMILY SSF53720 9 420 5.5E-122 T 13-10-2018 IPR016161 Aldehyde/histidinol dehydrogenase GO:0016491|GO:0055114 TOPB45_0425 2bdb03b94ea4f3434eddac7064394ab8 421 PIRSF PIRSF000151 4 421 8.3E-181 T 13-10-2018 IPR012134 Glutamate-5-semialdehyde dehydrogenase GO:0004350|GO:0006561|GO:0050661|GO:0055114 KEGG: 00330+1.2.1.41|KEGG: 00332+1.2.1.41|MetaCyc: PWY-3341|MetaCyc: PWY-6922 TOPB45_0425 2bdb03b94ea4f3434eddac7064394ab8 421 TIGRFAM TIGR00407 proA: glutamate-5-semialdehyde dehydrogenase 17 410 2.7E-148 T 13-10-2018 IPR000965 GPR domain GO:0004350|GO:0006561|GO:0055114 KEGG: 00330+1.2.1.41|KEGG: 00332+1.2.1.41|MetaCyc: PWY-3341|MetaCyc: PWY-6922|Reactome: R-HSA-70614 TOPB45_0425 2bdb03b94ea4f3434eddac7064394ab8 421 Pfam PF00171 Aldehyde dehydrogenase family 10 290 1.0E-18 T 13-10-2018 IPR015590 Aldehyde dehydrogenase domain GO:0016491|GO:0055114 TOPB45_1564 ede36baf25018ab56db02e3b610a803b 313 TIGRFAM TIGR02550 flagell_flgL: flagellar hook-associated protein 3 2 197 1.1E-40 T 13-10-2018 IPR013384 Flagellar hook-associated protein 3 GO:0009424|GO:0071973 TOPB45_1564 ede36baf25018ab56db02e3b610a803b 313 Pfam PF00669 Bacterial flagellin N-terminal helical region 14 140 2.2E-17 T 13-10-2018 IPR001029 Flagellin, D0/D1 domain GO:0005198|GO:0071973 TOPB45_1564 ede36baf25018ab56db02e3b610a803b 313 SUPERFAMILY SSF64518 1 313 4.45E-49 T 13-10-2018 TOPB45_1564 ede36baf25018ab56db02e3b610a803b 313 Gene3D G3DSA:1.20.1330.10 40 260 1.3E-38 T 13-10-2018 TOPB45_0977 6e879d53d4aadcffcd0edbcdc28ef6cc 384 Pfam PF09414 RNA ligase 95 251 1.7E-15 T 13-10-2018 IPR021122 RNA ligase domain, REL/Rln2 TOPB45_0977 6e879d53d4aadcffcd0edbcdc28ef6cc 384 TIGRFAM TIGR01209 TIGR01209: RNA ligase, Pab1020 family 29 379 5.4E-90 T 13-10-2018 IPR001072 RNA ligase, Pab1020 family TOPB45_0977 6e879d53d4aadcffcd0edbcdc28ef6cc 384 Gene3D G3DSA:3.30.1490.70 79 252 1.6E-62 T 13-10-2018 TOPB45_0977 6e879d53d4aadcffcd0edbcdc28ef6cc 384 SUPERFAMILY SSF56091 71 245 1.04E-25 T 13-10-2018 TOPB45_0977 6e879d53d4aadcffcd0edbcdc28ef6cc 384 Gene3D G3DSA:3.30.70.2160 253 384 2.1E-33 T 13-10-2018 TOPB45_0977 6e879d53d4aadcffcd0edbcdc28ef6cc 384 PRINTS PR01048 Hypothetical protein Y414 family signature 73 91 2.5E-39 T 13-10-2018 IPR001072 RNA ligase, Pab1020 family TOPB45_0977 6e879d53d4aadcffcd0edbcdc28ef6cc 384 PRINTS PR01048 Hypothetical protein Y414 family signature 148 163 2.5E-39 T 13-10-2018 IPR001072 RNA ligase, Pab1020 family TOPB45_0977 6e879d53d4aadcffcd0edbcdc28ef6cc 384 PRINTS PR01048 Hypothetical protein Y414 family signature 95 108 2.5E-39 T 13-10-2018 IPR001072 RNA ligase, Pab1020 family TOPB45_0977 6e879d53d4aadcffcd0edbcdc28ef6cc 384 PRINTS PR01048 Hypothetical protein Y414 family signature 299 313 2.5E-39 T 13-10-2018 IPR001072 RNA ligase, Pab1020 family TOPB45_0977 6e879d53d4aadcffcd0edbcdc28ef6cc 384 PRINTS PR01048 Hypothetical protein Y414 family signature 247 260 2.5E-39 T 13-10-2018 IPR001072 RNA ligase, Pab1020 family TOPB45_0977 6e879d53d4aadcffcd0edbcdc28ef6cc 384 PRINTS PR01048 Hypothetical protein Y414 family signature 359 379 2.5E-39 T 13-10-2018 IPR001072 RNA ligase, Pab1020 family TOPB45_0977 6e879d53d4aadcffcd0edbcdc28ef6cc 384 PRINTS PR01048 Hypothetical protein Y414 family signature 116 131 2.5E-39 T 13-10-2018 IPR001072 RNA ligase, Pab1020 family TOPB45_0977 6e879d53d4aadcffcd0edbcdc28ef6cc 384 PRINTS PR01048 Hypothetical protein Y414 family signature 271 289 2.5E-39 T 13-10-2018 IPR001072 RNA ligase, Pab1020 family TOPB45_0977 6e879d53d4aadcffcd0edbcdc28ef6cc 384 PRINTS PR01048 Hypothetical protein Y414 family signature 52 66 2.5E-39 T 13-10-2018 IPR001072 RNA ligase, Pab1020 family TOPB45_0977 6e879d53d4aadcffcd0edbcdc28ef6cc 384 PRINTS PR01048 Hypothetical protein Y414 family signature 174 195 2.5E-39 T 13-10-2018 IPR001072 RNA ligase, Pab1020 family TOPB45_0977 6e879d53d4aadcffcd0edbcdc28ef6cc 384 Gene3D G3DSA:3.30.470.30 104 207 1.6E-62 T 13-10-2018 TOPB45_0591 d79043ccd48732c684425e9a6667c512 212 Gene3D G3DSA:3.30.300.20 63 149 4.2E-7 T 13-10-2018 IPR015946 K homology domain-like, alpha/beta TOPB45_0591 d79043ccd48732c684425e9a6667c512 212 SMART SM01245 4 56 3.6E-5 T 13-10-2018 IPR032782 Jag, N-terminal TOPB45_0591 d79043ccd48732c684425e9a6667c512 212 Pfam PF14804 Jag N-terminus 6 54 2.6E-11 T 13-10-2018 IPR032782 Jag, N-terminal TOPB45_0591 d79043ccd48732c684425e9a6667c512 212 Gene3D G3DSA:3.30.30.80 2 56 1.1E-7 T 13-10-2018 IPR038247 Jag, N-terminal domain superfamily TOPB45_0092 f30c380ad6e4e45deae76746c433134b 657 Pfam PF00662 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus 75 131 1.5E-21 T 13-10-2018 IPR001516 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminal Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_0092 f30c380ad6e4e45deae76746c433134b 657 TIGRFAM TIGR01974 NDH_I_L: proton-translocating NADH-quinone oxidoreductase, chain L 16 652 2.3E-225 T 13-10-2018 IPR003945 NADH-plastoquinone oxidoreductase, chain 5 GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_0092 f30c380ad6e4e45deae76746c433134b 657 Pfam PF01010 NADH-dehyrogenase subunit F, TMs, (complex I) C-terminus 470 555 2.1E-8 T 13-10-2018 IPR002128 NADH:ubiquinone/plastoquinone oxidoreductase, chloroplast chain 5, C-terminal TOPB45_0092 f30c380ad6e4e45deae76746c433134b 657 PRINTS PR01435 NADH-plastoquinone oxidoreductase chain 5 signature 94 114 1.5E-15 T 13-10-2018 IPR018393 NADH-plastoquinone oxidoreductase, chain 5 subgroup GO:0008137|GO:0042773|GO:0055114 TOPB45_0092 f30c380ad6e4e45deae76746c433134b 657 PRINTS PR01435 NADH-plastoquinone oxidoreductase chain 5 signature 525 546 1.5E-15 T 13-10-2018 IPR018393 NADH-plastoquinone oxidoreductase, chain 5 subgroup GO:0008137|GO:0042773|GO:0055114 TOPB45_0092 f30c380ad6e4e45deae76746c433134b 657 PRINTS PR01435 NADH-plastoquinone oxidoreductase chain 5 signature 282 304 1.5E-15 T 13-10-2018 IPR018393 NADH-plastoquinone oxidoreductase, chain 5 subgroup GO:0008137|GO:0042773|GO:0055114 TOPB45_0092 f30c380ad6e4e45deae76746c433134b 657 PRINTS PR01435 NADH-plastoquinone oxidoreductase chain 5 signature 439 461 1.5E-15 T 13-10-2018 IPR018393 NADH-plastoquinone oxidoreductase, chain 5 subgroup GO:0008137|GO:0042773|GO:0055114 TOPB45_0092 f30c380ad6e4e45deae76746c433134b 657 PRINTS PR01435 NADH-plastoquinone oxidoreductase chain 5 signature 68 92 1.5E-15 T 13-10-2018 IPR018393 NADH-plastoquinone oxidoreductase, chain 5 subgroup GO:0008137|GO:0042773|GO:0055114 TOPB45_0092 f30c380ad6e4e45deae76746c433134b 657 PRINTS PR01435 NADH-plastoquinone oxidoreductase chain 5 signature 46 65 1.5E-15 T 13-10-2018 IPR018393 NADH-plastoquinone oxidoreductase, chain 5 subgroup GO:0008137|GO:0042773|GO:0055114 TOPB45_0092 f30c380ad6e4e45deae76746c433134b 657 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 440 459 6.9E-67 T 13-10-2018 TOPB45_0092 f30c380ad6e4e45deae76746c433134b 657 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 332 344 6.9E-67 T 13-10-2018 TOPB45_0092 f30c380ad6e4e45deae76746c433134b 657 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 92 117 6.9E-67 T 13-10-2018 TOPB45_0092 f30c380ad6e4e45deae76746c433134b 657 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 167 188 6.9E-67 T 13-10-2018 TOPB45_0092 f30c380ad6e4e45deae76746c433134b 657 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 120 140 6.9E-67 T 13-10-2018 TOPB45_0092 f30c380ad6e4e45deae76746c433134b 657 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 242 263 6.9E-67 T 13-10-2018 TOPB45_0092 f30c380ad6e4e45deae76746c433134b 657 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 264 290 6.9E-67 T 13-10-2018 TOPB45_0092 f30c380ad6e4e45deae76746c433134b 657 Pfam PF00361 Proton-conducting membrane transporter 143 436 2.0E-87 T 13-10-2018 IPR001750 NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_0630 72560556eac2d6c3a392ce5da1f8f4e8 661 SMART SM00955 274 556 1.9E-84 T 13-10-2018 IPR001900 Ribonuclease II/R GO:0003723|GO:0004540 TOPB45_0630 72560556eac2d6c3a392ce5da1f8f4e8 661 Pfam PF00773 RNB domain 274 554 5.6E-66 T 13-10-2018 IPR001900 Ribonuclease II/R GO:0003723|GO:0004540 TOPB45_0630 72560556eac2d6c3a392ce5da1f8f4e8 661 SUPERFAMILY SSF50249 226 596 3.83E-91 T 13-10-2018 IPR012340 Nucleic acid-binding, OB-fold TOPB45_0723 2d86211ab7492a4dc8e06df41edbb088 530 SUPERFAMILY SSF110921 431 518 1.83E-16 T 13-10-2018 IPR036230 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain superfamily KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871 TOPB45_0723 2d86211ab7492a4dc8e06df41edbb088 530 SMART SM00917 378 523 8.1E-36 T 13-10-2018 IPR013709 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain GO:0003852|GO:0009098 KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871 TOPB45_0723 2d86211ab7492a4dc8e06df41edbb088 530 ProSitePatterns PS00815 Alpha-isopropylmalate and homocitrate synthases signature 1. 13 29 - T 13-10-2018 IPR002034 Alpha-isopropylmalate/homocitrate synthase, conserved site GO:0019752|GO:0046912 KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871 TOPB45_0723 2d86211ab7492a4dc8e06df41edbb088 530 Gene3D G3DSA:3.20.20.70 5 329 6.6E-108 T 13-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 TOPB45_0723 2d86211ab7492a4dc8e06df41edbb088 530 TIGRFAM TIGR00977 citramal_synth: citramalate synthase 5 528 1.1E-233 T 13-10-2018 IPR005675 Citramalate synthase GO:0019752|GO:0046912 KEGG: 00290+2.3.1.182|KEGG: 00660+2.3.1.182|MetaCyc: PWY-5101 TOPB45_0723 2d86211ab7492a4dc8e06df41edbb088 530 Pfam PF08502 LeuA allosteric (dimerisation) domain 379 522 1.4E-25 T 13-10-2018 IPR013709 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain GO:0003852|GO:0009098 KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871 TOPB45_0723 2d86211ab7492a4dc8e06df41edbb088 530 Pfam PF00682 HMGL-like 5 279 2.1E-49 T 13-10-2018 IPR000891 Pyruvate carboxyltransferase GO:0003824 TOPB45_0723 2d86211ab7492a4dc8e06df41edbb088 530 SUPERFAMILY SSF51569 3 296 2.2E-81 T 13-10-2018 TOPB45_1550 55d08944c61f25fd5aa832f8cbee21bd 197 TIGRFAM TIGR01144 ATP_synt_b: ATP synthase F0, B subunit 46 190 1.7E-24 T 13-10-2018 IPR005864 ATP synthase, F0 complex, subunit b, bacterial GO:0015078|GO:0015986|GO:0045263 TOPB45_1550 55d08944c61f25fd5aa832f8cbee21bd 197 Hamap MF_01398 ATP synthase subunit b [atpF]. 33 173 12.591 T 13-10-2018 IPR002146 ATP synthase, F0 complex, subunit b/b', bacterial/chloroplast GO:0015078|GO:0015986|GO:0045263 TOPB45_1550 55d08944c61f25fd5aa832f8cbee21bd 197 Pfam PF00430 ATP synthase B/B' CF(0) 42 171 8.3E-22 T 13-10-2018 IPR002146 ATP synthase, F0 complex, subunit b/b', bacterial/chloroplast GO:0015078|GO:0015986|GO:0045263 TOPB45_0055 0479d98214f0d80091389d449a933166 623 SMART SM00028 193 226 31.0 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_0055 0479d98214f0d80091389d449a933166 623 SMART SM00028 392 425 1.4 T 13-10-2018 IPR019734 Tetratricopeptide repeat GO:0005515 TOPB45_0055 0479d98214f0d80091389d449a933166 623 Gene3D G3DSA:1.25.40.10 382 466 3.6E-5 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_0055 0479d98214f0d80091389d449a933166 623 SUPERFAMILY SSF48452 177 274 5.42E-6 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_0055 0479d98214f0d80091389d449a933166 623 Gene3D G3DSA:1.25.40.10 186 378 2.3E-10 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_1568 ca5e3592a030b0fdebdf9874934716d7 388 Pfam PF02119 Flagellar P-ring protein 25 387 1.3E-142 T 13-10-2018 IPR001782 Flagellar P-ring protein GO:0005198|GO:0009428|GO:0030288|GO:0071973 TOPB45_1568 ca5e3592a030b0fdebdf9874934716d7 388 PRINTS PR01010 Flagellar P-ring protein signature 275 287 2.8E-73 T 13-10-2018 IPR001782 Flagellar P-ring protein GO:0005198|GO:0009428|GO:0030288|GO:0071973 TOPB45_1568 ca5e3592a030b0fdebdf9874934716d7 388 PRINTS PR01010 Flagellar P-ring protein signature 25 40 2.8E-73 T 13-10-2018 IPR001782 Flagellar P-ring protein GO:0005198|GO:0009428|GO:0030288|GO:0071973 TOPB45_1568 ca5e3592a030b0fdebdf9874934716d7 388 PRINTS PR01010 Flagellar P-ring protein signature 123 141 2.8E-73 T 13-10-2018 IPR001782 Flagellar P-ring protein GO:0005198|GO:0009428|GO:0030288|GO:0071973 TOPB45_1568 ca5e3592a030b0fdebdf9874934716d7 388 PRINTS PR01010 Flagellar P-ring protein signature 84 103 2.8E-73 T 13-10-2018 IPR001782 Flagellar P-ring protein GO:0005198|GO:0009428|GO:0030288|GO:0071973 TOPB45_1568 ca5e3592a030b0fdebdf9874934716d7 388 PRINTS PR01010 Flagellar P-ring protein signature 40 55 2.8E-73 T 13-10-2018 IPR001782 Flagellar P-ring protein GO:0005198|GO:0009428|GO:0030288|GO:0071973 TOPB45_1568 ca5e3592a030b0fdebdf9874934716d7 388 PRINTS PR01010 Flagellar P-ring protein signature 59 74 2.8E-73 T 13-10-2018 IPR001782 Flagellar P-ring protein GO:0005198|GO:0009428|GO:0030288|GO:0071973 TOPB45_1568 ca5e3592a030b0fdebdf9874934716d7 388 PRINTS PR01010 Flagellar P-ring protein signature 211 229 2.8E-73 T 13-10-2018 IPR001782 Flagellar P-ring protein GO:0005198|GO:0009428|GO:0030288|GO:0071973 TOPB45_1568 ca5e3592a030b0fdebdf9874934716d7 388 PRINTS PR01010 Flagellar P-ring protein signature 106 123 2.8E-73 T 13-10-2018 IPR001782 Flagellar P-ring protein GO:0005198|GO:0009428|GO:0030288|GO:0071973 TOPB45_1568 ca5e3592a030b0fdebdf9874934716d7 388 Hamap MF_00416 Flagellar P-ring protein [flgI]. 7 388 36.277 T 13-10-2018 IPR001782 Flagellar P-ring protein GO:0005198|GO:0009428|GO:0030288|GO:0071973 TOPB45_0173 625cc4c88523d964a4be0213a2cdc716 397 SUPERFAMILY SSF103501 231 386 2.09E-15 T 13-10-2018 IPR036197 NarG-like superfamily TOPB45_0173 625cc4c88523d964a4be0213a2cdc716 397 Pfam PF13187 4Fe-4S dicluster domain 28 87 1.6E-7 T 13-10-2018 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain TOPB45_0173 625cc4c88523d964a4be0213a2cdc716 397 Gene3D G3DSA:1.10.1060.10 2 105 2.5E-7 T 13-10-2018 IPR009051 Alpha-helical ferredoxin GO:0051536 TOPB45_0173 625cc4c88523d964a4be0213a2cdc716 397 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 73 84 - T 13-10-2018 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site TOPB45_0173 625cc4c88523d964a4be0213a2cdc716 397 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 29 40 - T 13-10-2018 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site TOPB45_0173 625cc4c88523d964a4be0213a2cdc716 397 SUPERFAMILY SSF46548 24 97 1.92E-15 T 13-10-2018 IPR009051 Alpha-helical ferredoxin GO:0051536 TOPB45_1397 19d4a49a8921e00ea0c9382a9d746818 74 Gene3D G3DSA:1.20.58.660 2 72 3.7E-8 T 13-10-2018 TOPB45_1397 19d4a49a8921e00ea0c9382a9d746818 74 Pfam PF04325 Protein of unknown function (DUF465) 17 64 6.6E-10 T 13-10-2018 IPR007420 Protein of unknown function DUF465 TOPB45_1141 d2e39c5b629e909f041940965c4337e2 408 SUPERFAMILY SSF52402 43 266 3.75E-45 T 13-10-2018 TOPB45_1141 d2e39c5b629e909f041940965c4337e2 408 Gene3D G3DSA:3.40.50.620 20 338 1.9E-72 T 13-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TOPB45_1141 d2e39c5b629e909f041940965c4337e2 408 TIGRFAM TIGR00269 TIGR00269: TIGR00269 family protein 215 321 3.7E-21 T 13-10-2018 IPR000541 Cytoplasmic tRNA 2-thiolation protein 1 GO:0000049|GO:0002098|GO:0034227 Reactome: R-HSA-6782315 TOPB45_1141 d2e39c5b629e909f041940965c4337e2 408 Pfam PF01171 PP-loop family 70 240 3.3E-16 T 13-10-2018 IPR011063 tRNA(Ile)-lysidine/2-thiocytidine synthase, N-terminal Reactome: R-HSA-6782315 TOPB45_0426 010017b70e919d3fb91bcbc43a3d85d6 211 TIGRFAM TIGR00482 TIGR00482: nicotinate (nicotinamide) nucleotide adenylyltransferase 11 210 6.3E-51 T 13-10-2018 IPR005248 Nicotinate/nicotinamide nucleotide adenylyltransferase GO:0009435|GO:0016779 KEGG: 00760+2.7.7.18|MetaCyc: PWY-5381|MetaCyc: PWY-5653|MetaCyc: PWY-7761|Reactome: R-HSA-196807 TOPB45_0426 010017b70e919d3fb91bcbc43a3d85d6 211 Pfam PF01467 Cytidylyltransferase-like 11 184 1.6E-26 T 13-10-2018 IPR004821 Cytidyltransferase-like domain GO:0003824|GO:0009058 TOPB45_0426 010017b70e919d3fb91bcbc43a3d85d6 211 TIGRFAM TIGR00125 cyt_tran_rel: cytidyltransferase-like domain 10 72 6.4E-9 T 13-10-2018 IPR004821 Cytidyltransferase-like domain GO:0003824|GO:0009058 TOPB45_0426 010017b70e919d3fb91bcbc43a3d85d6 211 SUPERFAMILY SSF52374 7 211 1.31E-51 T 13-10-2018 TOPB45_0426 010017b70e919d3fb91bcbc43a3d85d6 211 Hamap MF_00244 Probable nicotinate-nucleotide adenylyltransferase [nadD]. 7 211 30.313 T 13-10-2018 IPR005248 Nicotinate/nicotinamide nucleotide adenylyltransferase GO:0009435|GO:0016779 KEGG: 00760+2.7.7.18|MetaCyc: PWY-5381|MetaCyc: PWY-5653|MetaCyc: PWY-7761|Reactome: R-HSA-196807 TOPB45_0426 010017b70e919d3fb91bcbc43a3d85d6 211 Gene3D G3DSA:3.40.50.620 6 211 9.6E-60 T 13-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TOPB45_1100 1f958ba4e28ebcd9411263a79df8d5f7 160 SUPERFAMILY SSF81301 31 152 1.08E-6 T 13-10-2018 TOPB45_1237 ce5ca2960892ec1e981183803804d352 374 Gene3D G3DSA:3.40.640.10 1 245 1.5E-85 T 13-10-2018 IPR015421 Pyridoxal phosphate-dependent transferase, major domain GO:0003824 TOPB45_1237 ce5ca2960892ec1e981183803804d352 374 Pfam PF01041 DegT/DnrJ/EryC1/StrS aminotransferase family 16 365 1.4E-111 T 13-10-2018 IPR000653 DegT/DnrJ/EryC1/StrS aminotransferase TOPB45_1237 ce5ca2960892ec1e981183803804d352 374 SUPERFAMILY SSF53383 13 369 3.9E-111 T 13-10-2018 IPR015424 Pyridoxal phosphate-dependent transferase TOPB45_1237 ce5ca2960892ec1e981183803804d352 374 Gene3D G3DSA:3.90.1150.10 247 371 5.8E-40 T 13-10-2018 IPR015422 Pyridoxal phosphate-dependent transferase domain 1 GO:0003824 TOPB45_1237 ce5ca2960892ec1e981183803804d352 374 PIRSF PIRSF000390 1 371 1.7E-105 T 13-10-2018 IPR000653 DegT/DnrJ/EryC1/StrS aminotransferase TOPB45_0760 9fa2cdcbcc1f4cc3aedbe9e1d0075b6b 138 TIGRFAM TIGR01164 rplP_bact: ribosomal protein uL16 3 127 7.3E-60 T 13-10-2018 IPR000114 Ribosomal protein L16 GO:0003735|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0760 9fa2cdcbcc1f4cc3aedbe9e1d0075b6b 138 Pfam PF00252 Ribosomal protein L16p/L10e 5 133 3.7E-53 T 13-10-2018 IPR016180 Ribosomal protein L10e/L16 GO:0003735|GO:0005840|GO:0006412 TOPB45_0760 9fa2cdcbcc1f4cc3aedbe9e1d0075b6b 138 SUPERFAMILY SSF54686 3 137 2.62E-59 T 13-10-2018 IPR036920 Ribosomal protein L10e/L16 superfamily GO:0003735|GO:0005840|GO:0006412 TOPB45_0760 9fa2cdcbcc1f4cc3aedbe9e1d0075b6b 138 PRINTS PR00060 Ribosomal protein L16 signature 43 54 2.1E-36 T 13-10-2018 IPR000114 Ribosomal protein L16 GO:0003735|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0760 9fa2cdcbcc1f4cc3aedbe9e1d0075b6b 138 PRINTS PR00060 Ribosomal protein L16 signature 25 37 2.1E-36 T 13-10-2018 IPR000114 Ribosomal protein L16 GO:0003735|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0760 9fa2cdcbcc1f4cc3aedbe9e1d0075b6b 138 PRINTS PR00060 Ribosomal protein L16 signature 59 88 2.1E-36 T 13-10-2018 IPR000114 Ribosomal protein L16 GO:0003735|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0760 9fa2cdcbcc1f4cc3aedbe9e1d0075b6b 138 PRINTS PR00060 Ribosomal protein L16 signature 89 118 2.1E-36 T 13-10-2018 IPR000114 Ribosomal protein L16 GO:0003735|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0760 9fa2cdcbcc1f4cc3aedbe9e1d0075b6b 138 ProSitePatterns PS00701 Ribosomal protein L16 signature 2. 83 94 - T 13-10-2018 IPR020798 Ribosomal protein L16, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0760 9fa2cdcbcc1f4cc3aedbe9e1d0075b6b 138 Gene3D G3DSA:3.90.1170.10 2 138 3.1E-60 T 13-10-2018 IPR036920 Ribosomal protein L10e/L16 superfamily GO:0003735|GO:0005840|GO:0006412 TOPB45_0760 9fa2cdcbcc1f4cc3aedbe9e1d0075b6b 138 ProSitePatterns PS00586 Ribosomal protein L16 signature 1. 60 71 - T 13-10-2018 IPR020798 Ribosomal protein L16, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0760 9fa2cdcbcc1f4cc3aedbe9e1d0075b6b 138 Hamap MF_01342 50S ribosomal protein L16 [rplP]. 2 135 38.44 T 13-10-2018 IPR000114 Ribosomal protein L16 GO:0003735|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_1275 f480be5a441d4ca20cbafc6f232c8811 260 SUPERFAMILY SSF55681 10 183 3.15E-34 T 13-10-2018 TOPB45_1275 f480be5a441d4ca20cbafc6f232c8811 260 Pfam PF03099 Biotin/lipoate A/B protein ligase family 51 127 9.9E-8 T 13-10-2018 IPR004143 Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL), catalytic domain GO:0006464 KEGG: 00785+2.3.1.181|MetaCyc: PWY-6987|MetaCyc: PWY-7382 TOPB45_1275 f480be5a441d4ca20cbafc6f232c8811 260 Gene3D G3DSA:3.30.930.10 12 199 3.6E-35 T 13-10-2018 TOPB45_1275 f480be5a441d4ca20cbafc6f232c8811 260 TIGRFAM TIGR00121 birA_ligase: biotin--[acetyl-CoA-carboxylase] ligase 18 256 1.3E-28 T 13-10-2018 IPR004408 Biotin--acetyl-CoA-carboxylase ligase GO:0004077|GO:0006464 KEGG: 00780+6.3.4.15|Reactome: R-HSA-196780|Reactome: R-HSA-3371599 TOPB45_1539 d8d2d9403c28d66b8e333df9f4796a94 255 SUPERFAMILY SSF103088 135 244 1.57E-21 T 13-10-2018 IPR036737 OmpA-like domain superfamily TOPB45_1539 d8d2d9403c28d66b8e333df9f4796a94 255 Pfam PF00691 OmpA family 142 234 9.5E-16 T 13-10-2018 IPR006665 OmpA-like domain TOPB45_1539 d8d2d9403c28d66b8e333df9f4796a94 255 Pfam PF13677 Membrane MotB of proton-channel complex MotA/MotB 12 61 5.7E-15 T 13-10-2018 IPR025713 Motility protein B, N-terminal domain TOPB45_1539 d8d2d9403c28d66b8e333df9f4796a94 255 Gene3D G3DSA:3.30.1330.60 93 254 5.7E-41 T 13-10-2018 IPR036737 OmpA-like domain superfamily TOPB45_0779 c76647272ee78fc80406744beef24d95 128 SUPERFAMILY SSF53137 14 128 2.27E-49 T 13-10-2018 TOPB45_0779 c76647272ee78fc80406744beef24d95 128 Pfam PF00411 Ribosomal protein S11 18 127 4.4E-47 T 13-10-2018 IPR001971 Ribosomal protein S11 GO:0003735|GO:0005840|GO:0006412 TOPB45_0779 c76647272ee78fc80406744beef24d95 128 Gene3D G3DSA:3.30.420.80 2 128 1.3E-54 T 13-10-2018 IPR036967 Ribosomal protein S11 superfamily GO:0003735|GO:0005840|GO:0006412 TOPB45_0779 c76647272ee78fc80406744beef24d95 128 TIGRFAM TIGR03632 uS11_bact: ribosomal protein uS11 9 125 5.9E-55 T 13-10-2018 IPR019981 Ribosomal protein S11, bacterial-type GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0779 c76647272ee78fc80406744beef24d95 128 ProSitePatterns PS00054 Ribosomal protein S11 signature. 96 118 - T 13-10-2018 IPR018102 Ribosomal S11, conserved site TOPB45_0779 c76647272ee78fc80406744beef24d95 128 PIRSF PIRSF002131 1 128 2.2E-53 T 13-10-2018 IPR001971 Ribosomal protein S11 GO:0003735|GO:0005840|GO:0006412 TOPB45_0779 c76647272ee78fc80406744beef24d95 128 Hamap MF_01310 30S ribosomal protein S11 [rpsK]. 5 128 33.01 T 13-10-2018 IPR001971 Ribosomal protein S11 GO:0003735|GO:0005840|GO:0006412 TOPB45_1319 09228e4ea74f90cd87ed01fa30dce344 274 SMART SM00138 3 271 5.3E-88 T 13-10-2018 IPR000780 MCP methyltransferase, CheR-type GO:0008757 TOPB45_1319 09228e4ea74f90cd87ed01fa30dce344 274 PRINTS PR00996 Glutamate methyltransferase family signature 65 77 3.0E-38 T 13-10-2018 IPR000780 MCP methyltransferase, CheR-type GO:0008757 TOPB45_1319 09228e4ea74f90cd87ed01fa30dce344 274 PRINTS PR00996 Glutamate methyltransferase family signature 141 157 3.0E-38 T 13-10-2018 IPR000780 MCP methyltransferase, CheR-type GO:0008757 TOPB45_1319 09228e4ea74f90cd87ed01fa30dce344 274 PRINTS PR00996 Glutamate methyltransferase family signature 210 224 3.0E-38 T 13-10-2018 IPR000780 MCP methyltransferase, CheR-type GO:0008757 TOPB45_1319 09228e4ea74f90cd87ed01fa30dce344 274 PRINTS PR00996 Glutamate methyltransferase family signature 25 38 3.0E-38 T 13-10-2018 IPR000780 MCP methyltransferase, CheR-type GO:0008757 TOPB45_1319 09228e4ea74f90cd87ed01fa30dce344 274 PRINTS PR00996 Glutamate methyltransferase family signature 105 125 3.0E-38 T 13-10-2018 IPR000780 MCP methyltransferase, CheR-type GO:0008757 TOPB45_1319 09228e4ea74f90cd87ed01fa30dce344 274 PRINTS PR00996 Glutamate methyltransferase family signature 229 252 3.0E-38 T 13-10-2018 IPR000780 MCP methyltransferase, CheR-type GO:0008757 TOPB45_1319 09228e4ea74f90cd87ed01fa30dce344 274 Gene3D G3DSA:3.40.50.150 71 272 1.8E-59 T 13-10-2018 TOPB45_1319 09228e4ea74f90cd87ed01fa30dce344 274 Pfam PF01739 CheR methyltransferase, SAM binding domain 72 251 1.2E-59 T 13-10-2018 IPR022642 MCP methyltransferase, CheR-type, SAM-binding domain, C-terminal TOPB45_1319 09228e4ea74f90cd87ed01fa30dce344 274 SUPERFAMILY SSF53335 72 255 2.67E-48 T 13-10-2018 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TOPB45_1319 09228e4ea74f90cd87ed01fa30dce344 274 Pfam PF03705 CheR methyltransferase, all-alpha domain 6 52 3.4E-7 T 13-10-2018 IPR022641 Chemotaxis receptor methyltransferase CheR, N-terminal TOPB45_1319 09228e4ea74f90cd87ed01fa30dce344 274 SUPERFAMILY SSF47757 2 71 1.03E-9 T 13-10-2018 TOPB45_1407 df3e3aec9dedea98106b102715cd7ee6 432 SUPERFAMILY SSF56014 160 289 8.97E-34 T 13-10-2018 TOPB45_1407 df3e3aec9dedea98106b102715cd7ee6 432 SUPERFAMILY SSF55124 6 159 1.14E-65 T 13-10-2018 IPR036136 Nitrite/Sulfite reductase ferredoxin-like domain superfamily GO:0016491|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 TOPB45_1407 df3e3aec9dedea98106b102715cd7ee6 432 Gene3D G3DSA:3.30.70.2500 57 157 6.7E-47 T 13-10-2018 TOPB45_1407 df3e3aec9dedea98106b102715cd7ee6 432 TIGRFAM TIGR02064 dsrA: sulfite reductase, dissimilatory-type alpha subunit 13 425 6.0E-167 T 13-10-2018 IPR011806 Sulphite reductase, dissimilatory-type alpha subunit GO:0018551|GO:0020037|GO:0051539|GO:0055114 TOPB45_1407 df3e3aec9dedea98106b102715cd7ee6 432 SUPERFAMILY SSF56014 272 430 6.1E-35 T 13-10-2018 TOPB45_1407 df3e3aec9dedea98106b102715cd7ee6 432 Pfam PF01077 Nitrite and sulphite reductase 4Fe-4S domain 159 389 2.7E-37 T 13-10-2018 IPR006067 Nitrite/sulphite reductase 4Fe-4S domain GO:0016491|GO:0020037|GO:0051536|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 TOPB45_1407 df3e3aec9dedea98106b102715cd7ee6 432 Gene3D G3DSA:3.30.70.20 232 317 1.8E-106 T 13-10-2018 TOPB45_1407 df3e3aec9dedea98106b102715cd7ee6 432 Gene3D G3DSA:3.30.413.10 158 409 1.8E-106 T 13-10-2018 TOPB45_0308 05d71dbfd79f7d6548228c62cf800880 460 Gene3D G3DSA:3.40.50.150 151 458 1.4E-85 T 13-10-2018 TOPB45_0308 05d71dbfd79f7d6548228c62cf800880 460 SUPERFAMILY SSF48013 8 160 3.27E-31 T 13-10-2018 IPR035926 NusB-like superfamily TOPB45_0308 05d71dbfd79f7d6548228c62cf800880 460 Pfam PF01189 16S rRNA methyltransferase RsmB/F 254 456 7.1E-66 T 13-10-2018 IPR001678 SAM-dependent methyltransferase RsmB/NOP2-type GO:0008168 TOPB45_0308 05d71dbfd79f7d6548228c62cf800880 460 Pfam PF01029 NusB family 8 132 2.0E-25 T 13-10-2018 IPR006027 NusB/RsmB/TIM44 GO:0003723|GO:0006355 TOPB45_0308 05d71dbfd79f7d6548228c62cf800880 460 SUPERFAMILY SSF53335 146 459 1.72E-77 T 13-10-2018 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TOPB45_0308 05d71dbfd79f7d6548228c62cf800880 460 ProSitePatterns PS01153 NOL1/NOP2/sun family signature. 332 343 - T 13-10-2018 IPR018314 Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site GO:0003723|GO:0008168 TOPB45_0308 05d71dbfd79f7d6548228c62cf800880 460 TIGRFAM TIGR00563 rsmB: 16S rRNA (cytosine(967)-C(5))-methyltransferase 10 458 2.0E-110 T 13-10-2018 IPR004573 rRNA small subunit methyltransferase B GO:0006364|GO:0008649 TOPB45_0308 05d71dbfd79f7d6548228c62cf800880 460 Gene3D G3DSA:1.10.940.10 5 150 3.9E-33 T 13-10-2018 IPR035926 NusB-like superfamily TOPB45_0308 05d71dbfd79f7d6548228c62cf800880 460 PRINTS PR02008 RNA (C5-cytosine) methyltransferase signature 265 275 4.8E-28 T 13-10-2018 IPR023267 RNA (C5-cytosine) methyltransferase TOPB45_0308 05d71dbfd79f7d6548228c62cf800880 460 PRINTS PR02008 RNA (C5-cytosine) methyltransferase signature 441 458 4.8E-28 T 13-10-2018 IPR023267 RNA (C5-cytosine) methyltransferase TOPB45_0308 05d71dbfd79f7d6548228c62cf800880 460 PRINTS PR02008 RNA (C5-cytosine) methyltransferase signature 236 250 4.8E-28 T 13-10-2018 IPR023267 RNA (C5-cytosine) methyltransferase TOPB45_0308 05d71dbfd79f7d6548228c62cf800880 460 PRINTS PR02008 RNA (C5-cytosine) methyltransferase signature 333 345 4.8E-28 T 13-10-2018 IPR023267 RNA (C5-cytosine) methyltransferase TOPB45_0308 05d71dbfd79f7d6548228c62cf800880 460 PRINTS PR02008 RNA (C5-cytosine) methyltransferase signature 383 399 4.8E-28 T 13-10-2018 IPR023267 RNA (C5-cytosine) methyltransferase TOPB45_1197 95bafc22c5aa55aa0a503004542d4c84 245 SUPERFAMILY SSF51366 7 238 3.77E-63 T 13-10-2018 IPR011060 Ribulose-phosphate binding barrel GO:0003824 TOPB45_1197 95bafc22c5aa55aa0a503004542d4c84 245 ProSitePatterns PS00156 Orotidine 5'-phosphate decarboxylase active site. 63 76 - T 13-10-2018 IPR018089 Orotidine 5'-phosphate decarboxylase, active site GO:0004590|GO:0006207 KEGG: 00240+4.1.1.23|MetaCyc: PWY-5686|MetaCyc: PWY-7790|MetaCyc: PWY-7791|Reactome: R-HSA-500753 TOPB45_1197 95bafc22c5aa55aa0a503004542d4c84 245 TIGRFAM TIGR01740 pyrF: orotidine 5'-phosphate decarboxylase 12 230 7.3E-54 T 13-10-2018 IPR014732 Orotidine 5'-phosphate decarboxylase GO:0004590|GO:0044205 KEGG: 00240+4.1.1.23|MetaCyc: PWY-5686|MetaCyc: PWY-7790|MetaCyc: PWY-7791|Reactome: R-HSA-500753 TOPB45_1197 95bafc22c5aa55aa0a503004542d4c84 245 SMART SM00934 10 230 2.7E-70 T 13-10-2018 IPR001754 Orotidine 5'-phosphate decarboxylase domain GO:0004590|GO:0006207 KEGG: 00240+4.1.1.23|MetaCyc: PWY-5686|MetaCyc: PWY-7790|MetaCyc: PWY-7791|Reactome: R-HSA-500753 TOPB45_1197 95bafc22c5aa55aa0a503004542d4c84 245 Gene3D G3DSA:3.20.20.70 8 241 7.0E-72 T 13-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 TOPB45_1197 95bafc22c5aa55aa0a503004542d4c84 245 Pfam PF00215 Orotidine 5'-phosphate decarboxylase / HUMPS family 14 229 1.5E-38 T 13-10-2018 IPR001754 Orotidine 5'-phosphate decarboxylase domain GO:0004590|GO:0006207 KEGG: 00240+4.1.1.23|MetaCyc: PWY-5686|MetaCyc: PWY-7790|MetaCyc: PWY-7791|Reactome: R-HSA-500753 TOPB45_1197 95bafc22c5aa55aa0a503004542d4c84 245 Hamap MF_01200_B Orotidine 5'-phosphate decarboxylase [pyrF]. 8 235 30.978 T 13-10-2018 IPR014732 Orotidine 5'-phosphate decarboxylase GO:0004590|GO:0044205 KEGG: 00240+4.1.1.23|MetaCyc: PWY-5686|MetaCyc: PWY-7790|MetaCyc: PWY-7791|Reactome: R-HSA-500753 TOPB45_1122 e9b119805a45139aba3648fea6ea54d6 130 Pfam PF02656 Domain of unknown function (DUF202) 14 93 3.7E-19 T 13-10-2018 IPR003807 Domain of unknown function DUF202 TOPB45_1293 6c5fb0c0e4fe343b05dfa2a7a9b8707b 598 PRINTS PR01042 Aspartyl-tRNA synthetase signature 214 227 1.4E-25 T 13-10-2018 IPR002312 Aspartyl/Asparaginyl-tRNA synthetase, class IIb GO:0000166|GO:0004812|GO:0005524|GO:0006418 TOPB45_1293 6c5fb0c0e4fe343b05dfa2a7a9b8707b 598 PRINTS PR01042 Aspartyl-tRNA synthetase signature 197 209 1.4E-25 T 13-10-2018 IPR002312 Aspartyl/Asparaginyl-tRNA synthetase, class IIb GO:0000166|GO:0004812|GO:0005524|GO:0006418 TOPB45_1293 6c5fb0c0e4fe343b05dfa2a7a9b8707b 598 PRINTS PR01042 Aspartyl-tRNA synthetase signature 482 498 1.4E-25 T 13-10-2018 IPR002312 Aspartyl/Asparaginyl-tRNA synthetase, class IIb GO:0000166|GO:0004812|GO:0005524|GO:0006418 TOPB45_1293 6c5fb0c0e4fe343b05dfa2a7a9b8707b 598 PRINTS PR01042 Aspartyl-tRNA synthetase signature 526 540 1.4E-25 T 13-10-2018 IPR002312 Aspartyl/Asparaginyl-tRNA synthetase, class IIb GO:0000166|GO:0004812|GO:0005524|GO:0006418 TOPB45_1293 6c5fb0c0e4fe343b05dfa2a7a9b8707b 598 Gene3D G3DSA:3.30.930.10 123 589 1.6E-191 T 13-10-2018 TOPB45_1293 6c5fb0c0e4fe343b05dfa2a7a9b8707b 598 Pfam PF00152 tRNA synthetases class II (D, K and N) 125 566 3.8E-108 T 13-10-2018 IPR004364 Aminoacyl-tRNA synthetase, class II (D/K/N) GO:0000166|GO:0004812|GO:0005524|GO:0006418 TOPB45_1293 6c5fb0c0e4fe343b05dfa2a7a9b8707b 598 SUPERFAMILY SSF55261 296 427 2.29E-31 T 13-10-2018 IPR004115 GAD-like domain superfamily GO:0004812|GO:0005524|GO:0005737 Reactome: R-HSA-379726 TOPB45_1293 6c5fb0c0e4fe343b05dfa2a7a9b8707b 598 Gene3D G3DSA:3.30.1360.30 279 427 1.6E-191 T 13-10-2018 IPR004115 GAD-like domain superfamily GO:0004812|GO:0005524|GO:0005737 Reactome: R-HSA-379726 TOPB45_1293 6c5fb0c0e4fe343b05dfa2a7a9b8707b 598 SUPERFAMILY SSF50249 5 109 4.76E-31 T 13-10-2018 IPR012340 Nucleic acid-binding, OB-fold TOPB45_1293 6c5fb0c0e4fe343b05dfa2a7a9b8707b 598 Hamap MF_00044 Aspartate--tRNA(Asp/Asn) ligase [aspS]. 4 592 33.868 T 13-10-2018 IPR004524 Aspartate-tRNA ligase, type 1 GO:0005524|GO:0016874 Reactome: R-HSA-379726 TOPB45_1293 6c5fb0c0e4fe343b05dfa2a7a9b8707b 598 Gene3D G3DSA:2.40.50.140 1 108 3.5E-32 T 13-10-2018 TOPB45_1293 6c5fb0c0e4fe343b05dfa2a7a9b8707b 598 TIGRFAM TIGR00459 aspS_bact: aspartate--tRNA ligase 4 589 2.5E-228 T 13-10-2018 IPR004524 Aspartate-tRNA ligase, type 1 GO:0005524|GO:0016874 Reactome: R-HSA-379726 TOPB45_1293 6c5fb0c0e4fe343b05dfa2a7a9b8707b 598 Pfam PF01336 OB-fold nucleic acid binding domain 23 106 1.8E-16 T 13-10-2018 IPR004365 OB-fold nucleic acid binding domain, AA-tRNA synthetase-type GO:0003676 TOPB45_1293 6c5fb0c0e4fe343b05dfa2a7a9b8707b 598 SUPERFAMILY SSF55681 121 588 5.16E-104 T 13-10-2018 TOPB45_1293 6c5fb0c0e4fe343b05dfa2a7a9b8707b 598 Pfam PF02938 GAD domain 315 413 3.1E-19 T 13-10-2018 IPR029351 GAD domain Reactome: R-HSA-379726 TOPB45_0394 8e52a39db5fca1ac73eaeb36d16a4a31 762 Gene3D G3DSA:1.10.8.190 1 112 5.0E-36 T 13-10-2018 TOPB45_0394 8e52a39db5fca1ac73eaeb36d16a4a31 762 Gene3D G3DSA:3.30.1650.10 346 528 3.3E-75 T 13-10-2018 IPR038571 Bifunctional carbon monoxide dehydrogenase/acetyl-coa synthase, domain 3 superfamily KEGG: 00720+2.3.1.169|MetaCyc: PWY-7784 TOPB45_0394 8e52a39db5fca1ac73eaeb36d16a4a31 762 Gene3D G3DSA:3.40.970.20 529 618 3.1E-39 T 13-10-2018 TOPB45_0394 8e52a39db5fca1ac73eaeb36d16a4a31 762 TIGRFAM TIGR00316 cdhC: CO dehydrogenase/CO-methylating acetyl-CoA synthase complex, beta subunit 347 757 5.5E-136 T 13-10-2018 IPR004461 CO dehydrogenase/acetyl-CoA synthase complex beta subunit GO:0006084|GO:0018492 KEGG: 00720+2.3.1.169|MetaCyc: PWY-7784 TOPB45_0394 8e52a39db5fca1ac73eaeb36d16a4a31 762 Gene3D G3DSA:3.40.1470.10 634 762 5.9E-50 T 13-10-2018 TOPB45_0394 8e52a39db5fca1ac73eaeb36d16a4a31 762 SUPERFAMILY SSF56821 7 761 3.8E-226 T 13-10-2018 IPR011254 Prismane-like superfamily GO:0003824|GO:0016491|GO:0055114 TOPB45_0394 8e52a39db5fca1ac73eaeb36d16a4a31 762 Pfam PF03598 CO dehydrogenase/acetyl-CoA synthase complex beta subunit 348 508 1.6E-67 T 13-10-2018 IPR004461 CO dehydrogenase/acetyl-CoA synthase complex beta subunit GO:0006084|GO:0018492 KEGG: 00720+2.3.1.169|MetaCyc: PWY-7784 TOPB45_0394 8e52a39db5fca1ac73eaeb36d16a4a31 762 Gene3D G3DSA:3.40.50.2030 118 339 3.4E-55 T 13-10-2018 IPR016099 Prismane-like, alpha/beta-sandwich GO:0003824|GO:0055114 KEGG: 00910+1.7.99.1 TOPB45_0683 3d1802cb8163fc4e11449c922dcd110b 204 Pfam PF09335 SNARE associated Golgi protein 37 166 9.9E-16 T 13-10-2018 IPR032816 SNARE associated Golgi protein TOPB45_0652 20073b043a11f770dd03bd271c2d9d76 351 SUPERFAMILY SSF48371 168 323 1.28E-9 T 13-10-2018 IPR016024 Armadillo-type fold TOPB45_0987 766a0f729cc6ce436b932a6dbe2d750f 160 SUPERFAMILY SSF64438 3 125 6.13E-14 T 13-10-2018 IPR011324 Cytotoxic necrotizing factor-like, catalytic TOPB45_0987 766a0f729cc6ce436b932a6dbe2d750f 160 Gene3D G3DSA:3.30.1330.200 1 156 2.6E-15 T 13-10-2018 IPR038592 CheD-like superfamily TOPB45_0643 87146b215e70626e769aac6a562e94c7 516 Pfam PF02775 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain 360 500 1.3E-28 T 13-10-2018 IPR011766 Thiamine pyrophosphate enzyme, C-terminal TPP-binding GO:0003824|GO:0030976 TOPB45_0643 87146b215e70626e769aac6a562e94c7 516 SUPERFAMILY SSF52518 330 508 5.57E-31 T 13-10-2018 IPR029061 Thiamin diphosphate-binding fold TOPB45_0643 87146b215e70626e769aac6a562e94c7 516 Gene3D G3DSA:3.40.50.970 1 182 2.5E-45 T 13-10-2018 TOPB45_0643 87146b215e70626e769aac6a562e94c7 516 Gene3D G3DSA:3.40.50.970 347 512 1.2E-20 T 13-10-2018 TOPB45_0643 87146b215e70626e769aac6a562e94c7 516 SUPERFAMILY SSF52518 1 193 2.42E-48 T 13-10-2018 IPR029061 Thiamin diphosphate-binding fold TOPB45_0643 87146b215e70626e769aac6a562e94c7 516 PIRSF PIRSF006439 1 516 8.6E-182 T 13-10-2018 IPR017721 Indolepyruvate ferredoxin oxidoreductase, alpha subunit GO:0043805|GO:0055114 TOPB45_1335 601240af9ab578672482001835002c1c 184 Gene3D G3DSA:2.30.330.10 92 184 1.1E-35 T 13-10-2018 IPR036429 SpoA-like superfamily TOPB45_1335 601240af9ab578672482001835002c1c 184 PRINTS PR00956 Flagellar motor switch protein FliN signature 120 136 8.2E-28 T 13-10-2018 IPR001172 Flagellar motor switch FliN/Type III secretion HrcQb GO:0003774|GO:0006935|GO:0009425|GO:0071973 TOPB45_1335 601240af9ab578672482001835002c1c 184 PRINTS PR00956 Flagellar motor switch protein FliN signature 136 149 8.2E-28 T 13-10-2018 IPR001172 Flagellar motor switch FliN/Type III secretion HrcQb GO:0003774|GO:0006935|GO:0009425|GO:0071973 TOPB45_1335 601240af9ab578672482001835002c1c 184 PRINTS PR00956 Flagellar motor switch protein FliN signature 103 119 8.2E-28 T 13-10-2018 IPR001172 Flagellar motor switch FliN/Type III secretion HrcQb GO:0003774|GO:0006935|GO:0009425|GO:0071973 TOPB45_1335 601240af9ab578672482001835002c1c 184 PRINTS PR00956 Flagellar motor switch protein FliN signature 149 164 8.2E-28 T 13-10-2018 IPR001172 Flagellar motor switch FliN/Type III secretion HrcQb GO:0003774|GO:0006935|GO:0009425|GO:0071973 TOPB45_1335 601240af9ab578672482001835002c1c 184 SUPERFAMILY SSF101801 101 181 5.49E-26 T 13-10-2018 IPR036429 SpoA-like superfamily TOPB45_1335 601240af9ab578672482001835002c1c 184 TIGRFAM TIGR02480 fliN: flagellar motor switch protein FliN 101 175 6.7E-33 T 13-10-2018 IPR012826 Flagellar motor switch FliN GO:0006935|GO:0009288|GO:0016020|GO:0071973 TOPB45_1335 601240af9ab578672482001835002c1c 184 Pfam PF01052 Type III flagellar switch regulator (C-ring) FliN C-term 104 173 1.8E-27 T 13-10-2018 IPR001543 Surface presentation of antigen (SpoA) TOPB45_1512 3acbaebce1455e97bc6394f4d071bfb9 387 SUPERFAMILY SSF52540 20 347 8.05E-54 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1512 3acbaebce1455e97bc6394f4d071bfb9 387 TIGRFAM TIGR01420 pilT_fam: twitching motility protein 17 356 8.0E-107 T 13-10-2018 IPR006321 Pilus retraction protein PilT GO:0005524 TOPB45_1512 3acbaebce1455e97bc6394f4d071bfb9 387 Gene3D G3DSA:3.40.50.300 114 370 1.4E-84 T 13-10-2018 TOPB45_1512 3acbaebce1455e97bc6394f4d071bfb9 387 Pfam PF00437 Type II/IV secretion system protein 89 258 2.4E-38 T 13-10-2018 IPR001482 Type II/IV secretion system protein TOPB45_1512 3acbaebce1455e97bc6394f4d071bfb9 387 SMART SM00382 135 260 0.0013 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_1512 3acbaebce1455e97bc6394f4d071bfb9 387 Gene3D G3DSA:3.30.450.90 3 112 2.9E-13 T 13-10-2018 TOPB45_0150 b06581fcfd908deaf5f031ace318c17c 132 Pfam PF08780 Nucleotidyltransferase substrate binding protein like 7 126 1.8E-33 T 13-10-2018 IPR010235 Nucleotidyltransferase substrate binding protein, HI0074 TOPB45_0150 b06581fcfd908deaf5f031ace318c17c 132 TIGRFAM TIGR01987 HI0074: nucleotidyltransferase substrate binding protein, HI0074 family 7 126 4.3E-31 T 13-10-2018 IPR010235 Nucleotidyltransferase substrate binding protein, HI0074 TOPB45_0150 b06581fcfd908deaf5f031ace318c17c 132 SUPERFAMILY SSF81593 3 124 2.47E-34 T 13-10-2018 TOPB45_0150 b06581fcfd908deaf5f031ace318c17c 132 Gene3D G3DSA:1.20.120.330 10 127 2.8E-44 T 13-10-2018 TOPB45_1260 f6a61f7207c5bb0c5c0e4bc08f33d5ad 113 SMART SM00938 4 106 3.9E-53 T 13-10-2018 IPR002187 Nitrogen regulatory protein PII GO:0006808|GO:0030234 TOPB45_1260 f6a61f7207c5bb0c5c0e4bc08f33d5ad 113 Pfam PF00543 Nitrogen regulatory protein P-II 4 106 2.4E-38 T 13-10-2018 IPR002187 Nitrogen regulatory protein PII GO:0006808|GO:0030234 TOPB45_1260 f6a61f7207c5bb0c5c0e4bc08f33d5ad 113 SUPERFAMILY SSF54913 1 113 1.14E-40 T 13-10-2018 IPR011322 Nitrogen regulatory PII-like, alpha/beta TOPB45_1260 f6a61f7207c5bb0c5c0e4bc08f33d5ad 113 PRINTS PR00340 P-II protein signature 2 17 5.3E-27 T 13-10-2018 IPR002187 Nitrogen regulatory protein PII GO:0006808|GO:0030234 TOPB45_1260 f6a61f7207c5bb0c5c0e4bc08f33d5ad 113 PRINTS PR00340 P-II protein signature 53 76 5.3E-27 T 13-10-2018 IPR002187 Nitrogen regulatory protein PII GO:0006808|GO:0030234 TOPB45_1260 f6a61f7207c5bb0c5c0e4bc08f33d5ad 113 PRINTS PR00340 P-II protein signature 84 104 5.3E-27 T 13-10-2018 IPR002187 Nitrogen regulatory protein PII GO:0006808|GO:0030234 TOPB45_1260 f6a61f7207c5bb0c5c0e4bc08f33d5ad 113 Gene3D G3DSA:3.30.70.120 1 113 9.1E-45 T 13-10-2018 IPR015867 Nitrogen regulatory protein PII/ATP phosphoribosyltransferase, C-terminal TOPB45_1260 f6a61f7207c5bb0c5c0e4bc08f33d5ad 113 ProSitePatterns PS00638 P-II protein C-terminal region signature. 84 97 - T 13-10-2018 IPR017918 Nitrogen regulatory protein PII, conserved site GO:0006808|GO:0030234 TOPB45_0511 010763362730f85e7b21b80cbc3b9c35 409 Pfam PF04932 O-Antigen ligase 190 340 8.9E-12 T 13-10-2018 IPR007016 O-antigen ligase-related TOPB45_0645 4edd23fcfeeffbedc87a552b0bb84e7d 434 SUPERFAMILY SSF56801 37 407 1.13E-59 T 13-10-2018 TOPB45_0645 4edd23fcfeeffbedc87a552b0bb84e7d 434 PIRSF PIRSF006444 1 433 3.7E-205 T 13-10-2018 IPR011880 Phenylacetate-CoA ligase GO:0010124|GO:0047475 KEGG: 00360+6.2.1.30|MetaCyc: PWY-1341|MetaCyc: PWY-6318|MetaCyc: PWY-7716 TOPB45_0645 4edd23fcfeeffbedc87a552b0bb84e7d 434 Pfam PF14535 AMP-binding enzyme C-terminal domain 335 431 1.4E-32 T 13-10-2018 IPR028154 AMP-dependent ligase, C-terminal TOPB45_0645 4edd23fcfeeffbedc87a552b0bb84e7d 434 Gene3D G3DSA:3.40.50.12780 1 328 1.7E-133 T 13-10-2018 TOPB45_0645 4edd23fcfeeffbedc87a552b0bb84e7d 434 Gene3D G3DSA:3.30.300.30 329 432 6.4E-35 T 13-10-2018 TOPB45_0645 4edd23fcfeeffbedc87a552b0bb84e7d 434 Pfam PF00501 AMP-binding enzyme 87 285 3.6E-16 T 13-10-2018 IPR000873 AMP-dependent synthetase/ligase GO:0003824 TOPB45_1359 ba419814410e305cbb4b8b5ca274a764 83 TIGRFAM TIGR00062 L27: ribosomal protein bL27 1 80 8.8E-37 T 13-10-2018 IPR001684 Ribosomal protein L27 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_1359 ba419814410e305cbb4b8b5ca274a764 83 ProSitePatterns PS00831 Ribosomal protein L27 signature. 34 48 - T 13-10-2018 IPR018261 Ribosomal protein L27, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_1359 ba419814410e305cbb4b8b5ca274a764 83 SUPERFAMILY SSF110324 2 80 2.09E-33 T 13-10-2018 TOPB45_1359 ba419814410e305cbb4b8b5ca274a764 83 ProDom PD003114 RIBOSOMAL L27 50S RIBONUCLEOPROTEIN CHLOROPLAST MITOCHONDRIAL PEPTIDE 60S TRANSIT PRECURSOR 28 83 2.0E-13 T 13-10-2018 IPR001684 Ribosomal protein L27 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_1359 ba419814410e305cbb4b8b5ca274a764 83 Hamap MF_00539 50S ribosomal protein L27 [rpmA]. 1 83 27.87 T 13-10-2018 IPR001684 Ribosomal protein L27 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_1359 ba419814410e305cbb4b8b5ca274a764 83 PRINTS PR00063 Ribosomal protein L27 signature 4 28 4.6E-38 T 13-10-2018 IPR001684 Ribosomal protein L27 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_1359 ba419814410e305cbb4b8b5ca274a764 83 PRINTS PR00063 Ribosomal protein L27 signature 29 53 4.6E-38 T 13-10-2018 IPR001684 Ribosomal protein L27 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_1359 ba419814410e305cbb4b8b5ca274a764 83 PRINTS PR00063 Ribosomal protein L27 signature 54 78 4.6E-38 T 13-10-2018 IPR001684 Ribosomal protein L27 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_1359 ba419814410e305cbb4b8b5ca274a764 83 Gene3D G3DSA:2.40.50.100 20 83 1.8E-29 T 13-10-2018 TOPB45_1359 ba419814410e305cbb4b8b5ca274a764 83 Pfam PF01016 Ribosomal L27 protein 2 80 2.2E-38 T 13-10-2018 IPR001684 Ribosomal protein L27 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_1176 0986ec6c856f60c843f0d354e4f42cea 171 SUPERFAMILY SSF103256 2 136 9.55E-46 T 13-10-2018 IPR036104 Bifunctional nuclease superfamily GO:0004518 TOPB45_1176 0986ec6c856f60c843f0d354e4f42cea 171 Pfam PF02577 Bifunctional nuclease 7 131 1.3E-46 T 13-10-2018 IPR003729 Bifunctional nuclease domain GO:0004518 TOPB45_1176 0986ec6c856f60c843f0d354e4f42cea 171 Gene3D G3DSA:3.10.690.10 1 142 1.4E-51 T 13-10-2018 IPR036104 Bifunctional nuclease superfamily GO:0004518 TOPB45_0557 e2efe9d558f3c12c401f84cdda3c8fac 78 Pfam PF06969 HemN C-terminal domain 7 72 2.1E-6 T 13-10-2018 IPR010723 HemN, C-terminal TOPB45_0557 e2efe9d558f3c12c401f84cdda3c8fac 78 SUPERFAMILY SSF46785 16 75 1.15E-9 T 13-10-2018 IPR036390 Winged helix DNA-binding domain superfamily TOPB45_0557 e2efe9d558f3c12c401f84cdda3c8fac 78 Gene3D G3DSA:1.10.10.10 11 76 4.4E-8 T 13-10-2018 IPR036388 Winged helix-like DNA-binding domain superfamily TOPB45_1329 568b1c1a63d1495652fa8dacafeec4e1 687 ProSitePatterns PS00994 Bacterial export FHIPEP family signature. 141 164 - T 13-10-2018 IPR025505 FHIPEP conserved site TOPB45_1329 568b1c1a63d1495652fa8dacafeec4e1 687 Gene3D G3DSA:1.10.490.80 584 682 6.8E-23 T 13-10-2018 TOPB45_1329 568b1c1a63d1495652fa8dacafeec4e1 687 Pfam PF00771 FHIPEP family 26 674 3.0E-255 T 13-10-2018 IPR001712 Type III secretion system FHIPEP GO:0009306|GO:0016020 TOPB45_1329 568b1c1a63d1495652fa8dacafeec4e1 687 TIGRFAM TIGR01398 FlhA: flagellar biosynthesis protein FlhA 16 682 9.3E-255 T 13-10-2018 IPR006301 Flagellar biosynthesis protein FlhA GO:0016021|GO:0044780 TOPB45_1329 568b1c1a63d1495652fa8dacafeec4e1 687 Gene3D G3DSA:3.40.30.60 350 494 1.3E-50 T 13-10-2018 TOPB45_1329 568b1c1a63d1495652fa8dacafeec4e1 687 Gene3D G3DSA:1.10.8.540 495 582 8.6E-27 T 13-10-2018 TOPB45_1329 568b1c1a63d1495652fa8dacafeec4e1 687 PRINTS PR00949 Type III secretion system inner membrane A protein family signature 69 88 8.5E-56 T 13-10-2018 IPR001712 Type III secretion system FHIPEP GO:0009306|GO:0016020 TOPB45_1329 568b1c1a63d1495652fa8dacafeec4e1 687 PRINTS PR00949 Type III secretion system inner membrane A protein family signature 155 173 8.5E-56 T 13-10-2018 IPR001712 Type III secretion system FHIPEP GO:0009306|GO:0016020 TOPB45_1329 568b1c1a63d1495652fa8dacafeec4e1 687 PRINTS PR00949 Type III secretion system inner membrane A protein family signature 236 250 8.5E-56 T 13-10-2018 IPR001712 Type III secretion system FHIPEP GO:0009306|GO:0016020 TOPB45_1329 568b1c1a63d1495652fa8dacafeec4e1 687 PRINTS PR00949 Type III secretion system inner membrane A protein family signature 136 152 8.5E-56 T 13-10-2018 IPR001712 Type III secretion system FHIPEP GO:0009306|GO:0016020 TOPB45_1329 568b1c1a63d1495652fa8dacafeec4e1 687 PRINTS PR00949 Type III secretion system inner membrane A protein family signature 32 45 8.5E-56 T 13-10-2018 IPR001712 Type III secretion system FHIPEP GO:0009306|GO:0016020 TOPB45_1329 568b1c1a63d1495652fa8dacafeec4e1 687 PRINTS PR00949 Type III secretion system inner membrane A protein family signature 185 202 8.5E-56 T 13-10-2018 IPR001712 Type III secretion system FHIPEP GO:0009306|GO:0016020 TOPB45_1329 568b1c1a63d1495652fa8dacafeec4e1 687 PIRSF PIRSF005419 1 687 6.5E-248 T 13-10-2018 IPR001712 Type III secretion system FHIPEP GO:0009306|GO:0016020 TOPB45_1374 8ee651d19a012397eec00f5de1b50085 228 SUPERFAMILY SSF53167 43 224 4.97E-26 T 13-10-2018 IPR035994 Nucleoside phosphorylase superfamily GO:0003824|GO:0009116 TOPB45_1374 8ee651d19a012397eec00f5de1b50085 228 Pfam PF01048 Phosphorylase superfamily 63 224 8.5E-16 T 13-10-2018 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 TOPB45_1374 8ee651d19a012397eec00f5de1b50085 228 Gene3D G3DSA:3.40.50.1580 24 224 2.6E-27 T 13-10-2018 TOPB45_0598 2a6454548204788f29fd576244e3d799 281 Gene3D G3DSA:1.10.10.2830 101 215 2.3E-39 T 13-10-2018 TOPB45_0598 2a6454548204788f29fd576244e3d799 281 Gene3D G3DSA:3.90.1530.30 36 100 2.8E-24 T 13-10-2018 TOPB45_0598 2a6454548204788f29fd576244e3d799 281 SUPERFAMILY SSF109709 106 216 3.66E-36 T 13-10-2018 TOPB45_0598 2a6454548204788f29fd576244e3d799 281 SUPERFAMILY SSF110849 22 116 5.75E-27 T 13-10-2018 IPR036086 ParB/Sulfiredoxin superfamily TOPB45_0598 2a6454548204788f29fd576244e3d799 281 TIGRFAM TIGR00180 parB_part: ParB/RepB/Spo0J family partition protein 23 195 7.0E-55 T 13-10-2018 IPR004437 ParB/RepB/Spo0J partition protein family GO:0003677 TOPB45_0598 2a6454548204788f29fd576244e3d799 281 Pfam PF02195 ParB-like nuclease domain 24 113 5.3E-25 T 13-10-2018 IPR003115 ParB/Sulfiredoxin TOPB45_0598 2a6454548204788f29fd576244e3d799 281 SMART SM00470 23 114 2.1E-32 T 13-10-2018 IPR003115 ParB/Sulfiredoxin TOPB45_0254 3fea8c00dd748b6270338f6afc23a72f 258 SUPERFAMILY SSF51161 100 245 1.16E-19 T 13-10-2018 IPR011004 Trimeric LpxA-like superfamily TOPB45_0254 3fea8c00dd748b6270338f6afc23a72f 258 Gene3D G3DSA:2.160.10.10 77 246 4.3E-32 T 13-10-2018 TOPB45_0176 8f34364c3aeb7595a4a6434cd9d573bf 666 TIGRFAM TIGR02061 aprA: adenylylsulfate reductase, alpha subunit 24 660 2.1E-300 T 13-10-2018 IPR011803 Adenylylsulphate reductase, alpha subunit KEGG: 00920+1.8.99.2|MetaCyc: PWY-5278|MetaCyc: PWY-5279 TOPB45_0176 8f34364c3aeb7595a4a6434cd9d573bf 666 Gene3D G3DSA:3.50.50.90 22 659 5.8E-283 T 13-10-2018 TOPB45_0176 8f34364c3aeb7595a4a6434cd9d573bf 666 SUPERFAMILY SSF51905 14 514 7.46E-64 T 13-10-2018 IPR036188 FAD/NAD(P)-binding domain superfamily TOPB45_0176 8f34364c3aeb7595a4a6434cd9d573bf 666 PIRSF PIRSF000171 13 663 2.1E-243 T 13-10-2018 TOPB45_0176 8f34364c3aeb7595a4a6434cd9d573bf 666 SUPERFAMILY SSF46977 528 660 8.5E-41 T 13-10-2018 IPR037099 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-71403 TOPB45_0176 8f34364c3aeb7595a4a6434cd9d573bf 666 SUPERFAMILY SSF56425 274 419 4.08E-68 T 13-10-2018 IPR027477 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily Reactome: R-HSA-611105|Reactome: R-HSA-71403 TOPB45_0176 8f34364c3aeb7595a4a6434cd9d573bf 666 Gene3D G3DSA:3.90.700.10 299 429 5.8E-283 T 13-10-2018 IPR027477 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily Reactome: R-HSA-611105|Reactome: R-HSA-71403 TOPB45_0176 8f34364c3aeb7595a4a6434cd9d573bf 666 Pfam PF00890 FAD binding domain 24 275 8.0E-12 T 13-10-2018 IPR003953 FAD-dependent oxidoreductase 2, FAD binding domain Reactome: R-HSA-611105|Reactome: R-HSA-71403 TOPB45_0176 8f34364c3aeb7595a4a6434cd9d573bf 666 Pfam PF02910 Fumarate reductase flavoprotein C-term 542 655 3.5E-6 T 13-10-2018 IPR015939 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-71403 TOPB45_1356 fe5f6998656717babd39b2e9ddd1cea8 277 Pfam PF07238 PilZ domain 186 256 9.5E-5 T 13-10-2018 IPR009875 PilZ domain GO:0035438 TOPB45_0716 2e2420a036f022e19d66530f431cd35f 129 Gene3D G3DSA:3.30.230.10 1 129 7.6E-52 T 13-10-2018 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup TOPB45_0716 2e2420a036f022e19d66530f431cd35f 129 Pfam PF00380 Ribosomal protein S9/S16 8 129 1.5E-47 T 13-10-2018 IPR000754 Ribosomal protein S9 GO:0003735|GO:0005840|GO:0006412 TOPB45_0716 2e2420a036f022e19d66530f431cd35f 129 ProSitePatterns PS00360 Ribosomal protein S9 signature. 68 86 - T 13-10-2018 IPR020574 Ribosomal protein S9, conserved site GO:0003735|GO:0005840|GO:0006412 TOPB45_0716 2e2420a036f022e19d66530f431cd35f 129 Hamap MF_00532_B 30S ribosomal protein S9 [rpsI]. 1 129 29.312 T 13-10-2018 IPR023035 Ribosomal protein S9, bacterial/plastid TOPB45_0716 2e2420a036f022e19d66530f431cd35f 129 SUPERFAMILY SSF54211 3 129 8.72E-46 T 13-10-2018 IPR020568 Ribosomal protein S5 domain 2-type fold TOPB45_0433 933825654277f161821a4982fb103daf 1142 Gene3D G3DSA:1.10.10.1600 439 515 1.8E-20 T 13-10-2018 TOPB45_0433 933825654277f161821a4982fb103daf 1142 Gene3D G3DSA:3.20.20.140 1 276 2.0E-107 T 13-10-2018 TOPB45_0433 933825654277f161821a4982fb103daf 1142 TIGRFAM TIGR00594 polc: DNA polymerase III, alpha subunit 4 1014 0.0 T 13-10-2018 IPR004805 DNA polymerase III, alpha subunit GO:0006260|GO:0008408 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TOPB45_0433 933825654277f161821a4982fb103daf 1142 SMART SM00481 5 72 3.5E-28 T 13-10-2018 IPR003141 Polymerase/histidinol phosphatase, N-terminal TOPB45_0433 933825654277f161821a4982fb103daf 1142 Pfam PF07733 Bacterial DNA polymerase III alpha subunit 298 729 2.1E-173 T 13-10-2018 IPR011708 Bacterial DNA polymerase III, alpha subunit GO:0006260|GO:0008408 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TOPB45_0433 933825654277f161821a4982fb103daf 1142 Pfam PF02811 PHP domain 6 177 3.1E-54 T 13-10-2018 IPR004013 PHP domain GO:0003824 TOPB45_0433 933825654277f161821a4982fb103daf 1142 Gene3D G3DSA:2.40.50.140 962 1054 1.2E-8 T 13-10-2018 TOPB45_0433 933825654277f161821a4982fb103daf 1142 Gene3D G3DSA:1.10.150.870 778 876 1.7E-7 T 13-10-2018 TOPB45_0433 933825654277f161821a4982fb103daf 1142 SUPERFAMILY SSF89550 4 260 1.41E-36 T 13-10-2018 IPR016195 Polymerase/histidinol phosphatase-like GO:0003824 Reactome: R-HSA-6784531|Reactome: R-HSA-6791226 TOPB45_0433 933825654277f161821a4982fb103daf 1142 Pfam PF14579 Helix-hairpin-helix motif 803 888 9.3E-27 T 13-10-2018 IPR029460 DNA polymerase, helix-hairpin-helix motif KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 TOPB45_0927 1bedb7d3914e87d61f0cc5fbdd072332 471 SUPERFAMILY SSF53244 320 449 3.89E-23 T 13-10-2018 IPR036615 Mur ligase, C-terminal domain superfamily GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 TOPB45_0927 1bedb7d3914e87d61f0cc5fbdd072332 471 Pfam PF01225 Mur ligase family, catalytic domain 3 99 1.1E-7 T 13-10-2018 IPR000713 Mur ligase, N-terminal catalytic domain GO:0005524|GO:0009058 TOPB45_0927 1bedb7d3914e87d61f0cc5fbdd072332 471 Pfam PF08245 Mur ligase middle domain 110 299 1.3E-23 T 13-10-2018 IPR013221 Mur ligase, central GO:0005524|GO:0009058 TOPB45_0927 1bedb7d3914e87d61f0cc5fbdd072332 471 Gene3D G3DSA:3.40.1190.10 94 318 3.0E-50 T 13-10-2018 IPR036565 Mur-like, catalytic domain superfamily GO:0005524|GO:0009058 Reactome: R-HSA-196757 TOPB45_0927 1bedb7d3914e87d61f0cc5fbdd072332 471 SUPERFAMILY SSF53623 94 318 6.02E-43 T 13-10-2018 IPR036565 Mur-like, catalytic domain superfamily GO:0005524|GO:0009058 Reactome: R-HSA-196757 TOPB45_0927 1bedb7d3914e87d61f0cc5fbdd072332 471 Gene3D G3DSA:3.90.190.20 319 468 8.2E-25 T 13-10-2018 IPR036615 Mur ligase, C-terminal domain superfamily GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 TOPB45_0927 1bedb7d3914e87d61f0cc5fbdd072332 471 Pfam PF02875 Mur ligase family, glutamate ligase domain 321 394 3.2E-9 T 13-10-2018 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 TOPB45_0927 1bedb7d3914e87d61f0cc5fbdd072332 471 SUPERFAMILY SSF51984 1 91 1.86E-15 T 13-10-2018 TOPB45_0927 1bedb7d3914e87d61f0cc5fbdd072332 471 Gene3D G3DSA:3.40.50.720 1 91 5.5E-23 T 13-10-2018 TOPB45_1604 1e95d00d7a6c5373fa2c73ab1cae25b8 222 Pfam PF06508 Queuosine biosynthesis protein QueC 6 211 2.0E-75 T 13-10-2018 IPR018317 Queuosine biosynthesis protein QueC KEGG: 00790+6.3.4.20|MetaCyc: PWY-6703 TOPB45_1604 1e95d00d7a6c5373fa2c73ab1cae25b8 222 PIRSF PIRSF006293 2 222 1.4E-78 T 13-10-2018 IPR018317 Queuosine biosynthesis protein QueC KEGG: 00790+6.3.4.20|MetaCyc: PWY-6703 TOPB45_1604 1e95d00d7a6c5373fa2c73ab1cae25b8 222 Hamap MF_01633 7-cyano-7-deazaguanine synthase [queC]. 4 217 49.563 T 13-10-2018 IPR018317 Queuosine biosynthesis protein QueC KEGG: 00790+6.3.4.20|MetaCyc: PWY-6703 TOPB45_1604 1e95d00d7a6c5373fa2c73ab1cae25b8 222 Gene3D G3DSA:3.40.50.620 3 222 1.7E-77 T 13-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TOPB45_1604 1e95d00d7a6c5373fa2c73ab1cae25b8 222 SUPERFAMILY SSF52402 6 219 5.51E-56 T 13-10-2018 TOPB45_1604 1e95d00d7a6c5373fa2c73ab1cae25b8 222 TIGRFAM TIGR00364 TIGR00364: queuosine biosynthesis protein QueC 6 204 7.2E-62 T 13-10-2018 IPR018317 Queuosine biosynthesis protein QueC KEGG: 00790+6.3.4.20|MetaCyc: PWY-6703 TOPB45_1051 372c8304445490cfc889c14bfcb805b4 423 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 209 329 3.7E-16 T 13-10-2018 IPR003959 ATPase, AAA-type, core GO:0005524 TOPB45_1051 372c8304445490cfc889c14bfcb805b4 423 SUPERFAMILY SSF52540 196 362 3.63E-25 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1051 372c8304445490cfc889c14bfcb805b4 423 SMART SM00382 204 332 1.1E-9 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_1051 372c8304445490cfc889c14bfcb805b4 423 Gene3D G3DSA:3.40.50.300 172 330 6.0E-25 T 13-10-2018 TOPB45_1623 dacd1b64375943f4926002d8a3e886f0 251 SUPERFAMILY SSF143631 10 238 4.84E-66 T 13-10-2018 IPR003374 ApbE-like superfamily TOPB45_1623 dacd1b64375943f4926002d8a3e886f0 251 Gene3D G3DSA:3.10.520.10 14 242 5.5E-77 T 13-10-2018 TOPB45_1623 dacd1b64375943f4926002d8a3e886f0 251 PIRSF PIRSF006421 12 247 2.0E-58 T 13-10-2018 IPR007183 Uncharacterised protein family UPF0280 TOPB45_0227 bce966112fe17ffbd91ff0b887dd6407 1044 Gene3D G3DSA:1.20.1640.10 513 1023 1.1E-294 T 13-10-2018 TOPB45_0227 bce966112fe17ffbd91ff0b887dd6407 1044 Gene3D G3DSA:3.30.70.1440 669 866 1.1E-294 T 13-10-2018 TOPB45_0227 bce966112fe17ffbd91ff0b887dd6407 1044 Pfam PF00873 AcrB/AcrD/AcrF family 2 1027 9.1E-301 T 13-10-2018 IPR001036 Acriflavin resistance protein GO:0016020|GO:0022857|GO:0055085 TOPB45_0227 bce966112fe17ffbd91ff0b887dd6407 1044 Gene3D G3DSA:3.30.2090.10 180 277 1.1E-294 T 13-10-2018 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains TOPB45_0227 bce966112fe17ffbd91ff0b887dd6407 1044 SUPERFAMILY SSF82693 565 671 9.94E-24 T 13-10-2018 TOPB45_0227 bce966112fe17ffbd91ff0b887dd6407 1044 Gene3D G3DSA:3.30.70.1430 39 817 1.1E-294 T 13-10-2018 TOPB45_0227 bce966112fe17ffbd91ff0b887dd6407 1044 PRINTS PR00702 Acriflavin resistance protein family signature 338 361 1.7E-73 T 13-10-2018 IPR001036 Acriflavin resistance protein GO:0016020|GO:0022857|GO:0055085 TOPB45_0227 bce966112fe17ffbd91ff0b887dd6407 1044 PRINTS PR00702 Acriflavin resistance protein family signature 9 33 1.7E-73 T 13-10-2018 IPR001036 Acriflavin resistance protein GO:0016020|GO:0022857|GO:0055085 TOPB45_0227 bce966112fe17ffbd91ff0b887dd6407 1044 PRINTS PR00702 Acriflavin resistance protein family signature 365 386 1.7E-73 T 13-10-2018 IPR001036 Acriflavin resistance protein GO:0016020|GO:0022857|GO:0055085 TOPB45_0227 bce966112fe17ffbd91ff0b887dd6407 1044 PRINTS PR00702 Acriflavin resistance protein family signature 552 569 1.7E-73 T 13-10-2018 IPR001036 Acriflavin resistance protein GO:0016020|GO:0022857|GO:0055085 TOPB45_0227 bce966112fe17ffbd91ff0b887dd6407 1044 PRINTS PR00702 Acriflavin resistance protein family signature 393 417 1.7E-73 T 13-10-2018 IPR001036 Acriflavin resistance protein GO:0016020|GO:0022857|GO:0055085 TOPB45_0227 bce966112fe17ffbd91ff0b887dd6407 1044 PRINTS PR00702 Acriflavin resistance protein family signature 471 494 1.7E-73 T 13-10-2018 IPR001036 Acriflavin resistance protein GO:0016020|GO:0022857|GO:0055085 TOPB45_0227 bce966112fe17ffbd91ff0b887dd6407 1044 PRINTS PR00702 Acriflavin resistance protein family signature 37 55 1.7E-73 T 13-10-2018 IPR001036 Acriflavin resistance protein GO:0016020|GO:0022857|GO:0055085 TOPB45_0227 bce966112fe17ffbd91ff0b887dd6407 1044 PRINTS PR00702 Acriflavin resistance protein family signature 621 635 1.7E-73 T 13-10-2018 IPR001036 Acriflavin resistance protein GO:0016020|GO:0022857|GO:0055085 TOPB45_0227 bce966112fe17ffbd91ff0b887dd6407 1044 PRINTS PR00702 Acriflavin resistance protein family signature 446 469 1.7E-73 T 13-10-2018 IPR001036 Acriflavin resistance protein GO:0016020|GO:0022857|GO:0055085 TOPB45_0227 bce966112fe17ffbd91ff0b887dd6407 1044 Gene3D G3DSA:1.20.1640.10 9 512 1.1E-294 T 13-10-2018 TOPB45_0227 bce966112fe17ffbd91ff0b887dd6407 1044 Gene3D G3DSA:3.30.70.1430 567 668 1.1E-294 T 13-10-2018 TOPB45_0227 bce966112fe17ffbd91ff0b887dd6407 1044 SUPERFAMILY SSF82693 40 131 2.09E-25 T 13-10-2018 TOPB45_0227 bce966112fe17ffbd91ff0b887dd6407 1044 SUPERFAMILY SSF82714 184 274 7.98E-18 T 13-10-2018 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains TOPB45_0227 bce966112fe17ffbd91ff0b887dd6407 1044 Gene3D G3DSA:3.30.2090.10 721 809 1.1E-294 T 13-10-2018 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains TOPB45_0227 bce966112fe17ffbd91ff0b887dd6407 1044 SUPERFAMILY SSF82693 137 332 3.77E-15 T 13-10-2018 TOPB45_0227 bce966112fe17ffbd91ff0b887dd6407 1044 Gene3D G3DSA:3.30.70.1320 134 334 1.1E-294 T 13-10-2018 TOPB45_0227 bce966112fe17ffbd91ff0b887dd6407 1044 TIGRFAM TIGR00915 2A0602: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family 3 1029 0.0 T 13-10-2018 IPR004764 Hydrophobe/amphiphile efflux-1 HAE1 GO:0006855|GO:0015562|GO:0016021 TOPB45_0227 bce966112fe17ffbd91ff0b887dd6407 1044 SUPERFAMILY SSF82714 722 805 4.97E-19 T 13-10-2018 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains TOPB45_0227 bce966112fe17ffbd91ff0b887dd6407 1044 SUPERFAMILY SSF82866 299 499 1.02E-45 T 13-10-2018 TOPB45_0227 bce966112fe17ffbd91ff0b887dd6407 1044 SUPERFAMILY SSF82866 806 1027 1.83E-45 T 13-10-2018 TOPB45_0028 ce180da865b28413e9e685de73b86283 318 Gene3D G3DSA:3.30.360.10 126 303 1.4E-60 T 13-10-2018 TOPB45_0028 ce180da865b28413e9e685de73b86283 318 SUPERFAMILY SSF55347 144 285 7.52E-11 T 13-10-2018 TOPB45_0028 ce180da865b28413e9e685de73b86283 318 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 4 125 1.0E-22 T 13-10-2018 IPR000683 Oxidoreductase, N-terminal GO:0016491 TOPB45_0028 ce180da865b28413e9e685de73b86283 318 Gene3D G3DSA:3.40.50.720 4 291 1.4E-60 T 13-10-2018 TOPB45_0028 ce180da865b28413e9e685de73b86283 318 SUPERFAMILY SSF51735 3 155 4.4E-36 T 13-10-2018 IPR036291 NAD(P)-binding domain superfamily TOPB45_0201 ba3c2da953e0e5d4498efd86377ad293 183 PIRSF PIRSF039093 6 183 9.4E-88 T 13-10-2018 IPR022281 ATP-dependent protease, HslV subunit GO:0004298|GO:0006508|GO:0009376 TOPB45_0201 ba3c2da953e0e5d4498efd86377ad293 183 Hamap MF_00248 ATP-dependent protease subunit HslV [hslV]. 12 183 41.498 T 13-10-2018 IPR022281 ATP-dependent protease, HslV subunit GO:0004298|GO:0006508|GO:0009376 TOPB45_0201 ba3c2da953e0e5d4498efd86377ad293 183 TIGRFAM TIGR03692 ATP_dep_HslV: ATP-dependent protease HslVU, peptidase subunit 13 183 6.4E-84 T 13-10-2018 IPR022281 ATP-dependent protease, HslV subunit GO:0004298|GO:0006508|GO:0009376 TOPB45_0201 ba3c2da953e0e5d4498efd86377ad293 183 SUPERFAMILY SSF56235 9 182 1.57E-57 T 13-10-2018 IPR029055 Nucleophile aminohydrolases, N-terminal TOPB45_0201 ba3c2da953e0e5d4498efd86377ad293 183 Pfam PF00227 Proteasome subunit 9 181 5.5E-24 T 13-10-2018 IPR001353 Proteasome, subunit alpha/beta GO:0004298|GO:0005839|GO:0051603 Reactome: R-HSA-1169091|Reactome: R-HSA-1234176|Reactome: R-HSA-1236974|Reactome: R-HSA-1236978|Reactome: R-HSA-174084|Reactome: R-HSA-174113|Reactome: R-HSA-174154|Reactome: R-HSA-174178|Reactome: R-HSA-174184|Reactome: R-HSA-180534|Reactome: R-HSA-180585|Reactome: R-HSA-187577|Reactome: R-HSA-195253|Reactome: R-HSA-202424|Reactome: R-HSA-211733|Reactome: R-HSA-2467813|Reactome: R-HSA-2871837|Reactome: R-HSA-349425|Reactome: R-HSA-350562|Reactome: R-HSA-382556|Reactome: R-HSA-450408|Reactome: R-HSA-4608870|Reactome: R-HSA-4641257|Reactome: R-HSA-4641258|Reactome: R-HSA-5358346|Reactome: R-HSA-5362768|Reactome: R-HSA-5607761|Reactome: R-HSA-5607764|Reactome: R-HSA-5610780|Reactome: R-HSA-5610783|Reactome: R-HSA-5610785|Reactome: R-HSA-5632684|Reactome: R-HSA-5658442|Reactome: R-HSA-5668541|Reactome: R-HSA-5676590|Reactome: R-HSA-5678895|Reactome: R-HSA-5687128|Reactome: R-HSA-5689603|Reactome: R-HSA-5689880|Reactome: R-HSA-68827|Reactome: R-HSA-68949|Reactome: R-HSA-69017|Reactome: R-HSA-69229|Reactome: R-HSA-69481|Reactome: R-HSA-69601|Reactome: R-HSA-8852276|Reactome: R-HSA-8854050|Reactome: R-HSA-8939236|Reactome: R-HSA-8939902|Reactome: R-HSA-8941858|Reactome: R-HSA-8948751|Reactome: R-HSA-8951664|Reactome: R-HSA-9010553|Reactome: R-HSA-9020702|Reactome: R-HSA-9604323|Reactome: R-HSA-983168 TOPB45_0201 ba3c2da953e0e5d4498efd86377ad293 183 Gene3D G3DSA:3.60.20.10 8 183 1.5E-66 T 13-10-2018 IPR029055 Nucleophile aminohydrolases, N-terminal TOPB45_0929 27136266a169005cbbe7596c37f7b0c2 311 SUPERFAMILY SSF52402 4 231 6.16E-22 T 13-10-2018 TOPB45_0929 27136266a169005cbbe7596c37f7b0c2 311 Pfam PF02568 Thiamine biosynthesis protein (ThiI) 4 146 5.5E-9 T 13-10-2018 IPR020536 Thil, AANH domain GO:0004810 KEGG: 00730+2.8.1.4 TOPB45_0929 27136266a169005cbbe7596c37f7b0c2 311 Gene3D G3DSA:3.40.50.620 3 190 6.6E-37 T 13-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TOPB45_0675 ce3196e4f5a5295ffb4b4abb44b83ee0 144 Pfam PF01597 Glycine cleavage H-protein 9 123 1.6E-28 T 13-10-2018 IPR033753 Glycine cleavage system H-protein/Simiate TOPB45_0675 ce3196e4f5a5295ffb4b4abb44b83ee0 144 Gene3D G3DSA:2.40.50.100 1 126 2.5E-37 T 13-10-2018 TOPB45_0675 ce3196e4f5a5295ffb4b4abb44b83ee0 144 SUPERFAMILY SSF51230 4 123 8.63E-29 T 13-10-2018 IPR011053 Single hybrid motif TOPB45_0334 58fdc205215d1fcde71ffb2b7adde784 73 Pfam PF10047 Protein of unknown function (DUF2281) 7 65 4.3E-19 T 13-10-2018 IPR018739 Domain of unknown function DUF2281 TOPB45_1007 40b5b1ab83d384099b781a77a26d7128 311 TIGRFAM TIGR00460 fmt: methionyl-tRNA formyltransferase 5 303 1.2E-90 T 13-10-2018 IPR005794 Methionyl-tRNA formyltransferase GO:0004479|GO:0071951 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9|Reactome: R-HSA-5368286 TOPB45_1007 40b5b1ab83d384099b781a77a26d7128 311 Pfam PF02911 Formyl transferase, C-terminal domain 206 302 4.8E-27 T 13-10-2018 IPR005793 Formyl transferase, C-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 TOPB45_1007 40b5b1ab83d384099b781a77a26d7128 311 ProSitePatterns PS00373 Phosphoribosylglycinamide formyltransferase active site. 134 157 - T 13-10-2018 IPR001555 Phosphoribosylglycinamide formyltransferase, active site KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 TOPB45_1007 40b5b1ab83d384099b781a77a26d7128 311 Gene3D G3DSA:3.40.50.170 1 207 1.0E-81 T 13-10-2018 TOPB45_1007 40b5b1ab83d384099b781a77a26d7128 311 Hamap MF_00182 Methionyl-tRNA formyltransferase [fmt]. 4 305 36.02 T 13-10-2018 IPR005794 Methionyl-tRNA formyltransferase GO:0004479|GO:0071951 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9|Reactome: R-HSA-5368286 TOPB45_1007 40b5b1ab83d384099b781a77a26d7128 311 SUPERFAMILY SSF53328 5 208 6.02E-68 T 13-10-2018 IPR036477 Formyl transferase, N-terminal domain superfamily GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 TOPB45_1007 40b5b1ab83d384099b781a77a26d7128 311 Gene3D G3DSA:3.10.25.10 208 309 1.7E-29 T 13-10-2018 IPR037022 Formyl transferase, C-terminal domain superfamily GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 TOPB45_1007 40b5b1ab83d384099b781a77a26d7128 311 Pfam PF00551 Formyl transferase 5 182 7.5E-47 T 13-10-2018 IPR002376 Formyl transferase, N-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 TOPB45_1007 40b5b1ab83d384099b781a77a26d7128 311 SUPERFAMILY SSF50486 206 308 2.67E-28 T 13-10-2018 IPR011034 Formyl transferase-like, C-terminal domain superfamily GO:0003824 TOPB45_1513 5c7c81f05541b0e1083abc7dd66c46d1 363 TIGRFAM TIGR01420 pilT_fam: twitching motility protein 4 343 3.7E-142 T 13-10-2018 IPR006321 Pilus retraction protein PilT GO:0005524 TOPB45_1513 5c7c81f05541b0e1083abc7dd66c46d1 363 Gene3D G3DSA:3.30.450.90 1 100 1.1E-34 T 13-10-2018 TOPB45_1513 5c7c81f05541b0e1083abc7dd66c46d1 363 ProSitePatterns PS00662 Bacterial type II secretion system protein E signature. 194 208 - T 13-10-2018 IPR001482 Type II/IV secretion system protein TOPB45_1513 5c7c81f05541b0e1083abc7dd66c46d1 363 Gene3D G3DSA:3.40.50.300 102 356 6.3E-97 T 13-10-2018 TOPB45_1513 5c7c81f05541b0e1083abc7dd66c46d1 363 SUPERFAMILY SSF52540 3 336 1.7E-70 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1513 5c7c81f05541b0e1083abc7dd66c46d1 363 SMART SM00382 123 249 4.5E-5 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_1513 5c7c81f05541b0e1083abc7dd66c46d1 363 Pfam PF00437 Type II/IV secretion system protein 36 266 3.7E-37 T 13-10-2018 IPR001482 Type II/IV secretion system protein TOPB45_0090 7f27ae7e3fe4e3def8f39e76eb7709a9 482 TIGRFAM TIGR01770 NDH_I_N: proton-translocating NADH-quinone oxidoreductase, chain N 9 463 5.7E-109 T 13-10-2018 IPR010096 NAD(P)H-quinone oxidoreductase, subunit N/subunit 2 GO:0008137|GO:0042773|GO:0055114 TOPB45_0090 7f27ae7e3fe4e3def8f39e76eb7709a9 482 Hamap MF_00445 NAD(P)H-quinone oxidoreductase subunit 2, chloroplastic [ndhB]. 5 464 16.051 T 13-10-2018 IPR010096 NAD(P)H-quinone oxidoreductase, subunit N/subunit 2 GO:0008137|GO:0042773|GO:0055114 TOPB45_0090 7f27ae7e3fe4e3def8f39e76eb7709a9 482 Pfam PF00361 Proton-conducting membrane transporter 120 412 2.5E-62 T 13-10-2018 IPR001750 NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_1214 8f32921e63b14b4612e7ea33952c6100 115 PRINTS PR01853 Bacterial YajC preprotein translocase signature 71 89 4.0E-15 T 13-10-2018 IPR003849 Preprotein translocase YajC TOPB45_1214 8f32921e63b14b4612e7ea33952c6100 115 PRINTS PR01853 Bacterial YajC preprotein translocase signature 33 53 4.0E-15 T 13-10-2018 IPR003849 Preprotein translocase YajC TOPB45_1214 8f32921e63b14b4612e7ea33952c6100 115 SMART SM01323 31 113 1.1E-32 T 13-10-2018 IPR003849 Preprotein translocase YajC TOPB45_1214 8f32921e63b14b4612e7ea33952c6100 115 Pfam PF02699 Preprotein translocase subunit 35 110 4.3E-26 T 13-10-2018 IPR003849 Preprotein translocase YajC TOPB45_1214 8f32921e63b14b4612e7ea33952c6100 115 TIGRFAM TIGR00739 yajC: preprotein translocase, YajC subunit 32 110 5.9E-27 T 13-10-2018 IPR003849 Preprotein translocase YajC TOPB45_0026 59c168b7fe0dc7cbe73dc690b226f8f3 430 PIRSF PIRSF000414 24 430 1.2E-103 T 13-10-2018 IPR002695 Bifunctional purine biosynthesis protein PurH-like GO:0003937|GO:0004643|GO:0006164 KEGG: 00230+3.5.4.10+2.1.2.3|KEGG: 00670+2.1.2.3|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234|Reactome: R-HSA-73817 TOPB45_0026 59c168b7fe0dc7cbe73dc690b226f8f3 430 Pfam PF01808 AICARFT/IMPCHase bienzyme 45 317 9.9E-61 T 13-10-2018 IPR002695 Bifunctional purine biosynthesis protein PurH-like GO:0003937|GO:0004643|GO:0006164 KEGG: 00230+3.5.4.10+2.1.2.3|KEGG: 00670+2.1.2.3|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234|Reactome: R-HSA-73817 TOPB45_0026 59c168b7fe0dc7cbe73dc690b226f8f3 430 SUPERFAMILY SSF53927 47 430 2.11E-99 T 13-10-2018 IPR016193 Cytidine deaminase-like GO:0003824 TOPB45_0026 59c168b7fe0dc7cbe73dc690b226f8f3 430 Gene3D G3DSA:3.40.140.20 46 216 2.0E-45 T 13-10-2018 IPR024051 AICAR transformylase, duplicated domain superfamily KEGG: 00230+3.5.4.10+2.1.2.3|KEGG: 00670+2.1.2.3|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234|Reactome: R-HSA-73817 TOPB45_0026 59c168b7fe0dc7cbe73dc690b226f8f3 430 SMART SM00798 11 319 1.4E-35 T 13-10-2018 IPR002695 Bifunctional purine biosynthesis protein PurH-like GO:0003937|GO:0004643|GO:0006164 KEGG: 00230+3.5.4.10+2.1.2.3|KEGG: 00670+2.1.2.3|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234|Reactome: R-HSA-73817 TOPB45_1468 889af9e18997125756be589f02800388 160 SUPERFAMILY SSF50341 23 159 4.05E-29 T 13-10-2018 IPR036061 CheW-like domain superfamily GO:0006935|GO:0007165 TOPB45_1468 889af9e18997125756be589f02800388 160 Pfam PF01584 CheW-like domain 27 159 2.5E-24 T 13-10-2018 IPR002545 CheW-like domain GO:0006935|GO:0007165 TOPB45_1468 889af9e18997125756be589f02800388 160 Gene3D G3DSA:2.40.50.180 43 158 2.5E-30 T 13-10-2018 TOPB45_1468 889af9e18997125756be589f02800388 160 SMART SM00260 22 158 4.6E-24 T 13-10-2018 IPR002545 CheW-like domain GO:0006935|GO:0007165 TOPB45_1468 889af9e18997125756be589f02800388 160 Gene3D G3DSA:2.30.30.40 28 152 2.5E-30 T 13-10-2018 TOPB45_1291 6a31aff70dc474adf6293210cb999f2f 269 SUPERFAMILY SSF81345 13 265 1.03E-11 T 13-10-2018 IPR037294 ABC transporter, BtuC-like TOPB45_1291 6a31aff70dc474adf6293210cb999f2f 269 Pfam PF00950 ABC 3 transport family 8 264 2.2E-31 T 13-10-2018 IPR001626 ABC transporter, TroCD-like GO:0005887|GO:0042626|GO:0043190|GO:0055085 TOPB45_1409 a13ce15b8df161c39ba271b4bf68e97b 253 Gene3D G3DSA:3.40.140.10 110 253 5.5E-51 T 13-10-2018 TOPB45_1409 a13ce15b8df161c39ba271b4bf68e97b 253 Pfam PF02634 FdhD/NarQ family 26 251 2.2E-69 T 13-10-2018 IPR003786 Sulfur carrier protein FdhD GO:0016783 TOPB45_1409 a13ce15b8df161c39ba271b4bf68e97b 253 PIRSF PIRSF015626 2 253 3.9E-73 T 13-10-2018 IPR003786 Sulfur carrier protein FdhD GO:0016783 TOPB45_1409 a13ce15b8df161c39ba271b4bf68e97b 253 Hamap MF_00187 Sulfur carrier protein FdhD [fdhD]. 2 252 29.837 T 13-10-2018 IPR003786 Sulfur carrier protein FdhD GO:0016783 TOPB45_1409 a13ce15b8df161c39ba271b4bf68e97b 253 TIGRFAM TIGR00129 fdhD_narQ: formate dehydrogenase family accessory protein FdhD 21 252 5.7E-61 T 13-10-2018 IPR003786 Sulfur carrier protein FdhD GO:0016783 TOPB45_1409 a13ce15b8df161c39ba271b4bf68e97b 253 Gene3D G3DSA:3.10.20.10 27 105 7.0E-9 T 13-10-2018 TOPB45_1409 a13ce15b8df161c39ba271b4bf68e97b 253 SUPERFAMILY SSF53927 4 251 3.61E-67 T 13-10-2018 IPR016193 Cytidine deaminase-like GO:0003824 TOPB45_0829 76ac32be24a76e2303db5232caff750f 332 Gene3D G3DSA:1.10.1060.10 1 83 2.9E-8 T 13-10-2018 IPR009051 Alpha-helical ferredoxin GO:0051536 TOPB45_0829 76ac32be24a76e2303db5232caff750f 332 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 55 66 - T 13-10-2018 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site TOPB45_0829 76ac32be24a76e2303db5232caff750f 332 Pfam PF02754 Cysteine-rich domain 116 198 8.1E-8 T 13-10-2018 IPR004017 Cysteine-rich domain TOPB45_0829 76ac32be24a76e2303db5232caff750f 332 Pfam PF02754 Cysteine-rich domain 266 315 0.14 T 13-10-2018 IPR004017 Cysteine-rich domain TOPB45_0829 76ac32be24a76e2303db5232caff750f 332 SUPERFAMILY SSF54862 9 85 2.01E-13 T 13-10-2018 TOPB45_0829 76ac32be24a76e2303db5232caff750f 332 Pfam PF13183 4Fe-4S dicluster domain 11 69 2.3E-9 T 13-10-2018 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain TOPB45_0829 76ac32be24a76e2303db5232caff750f 332 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 13 24 - T 13-10-2018 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site TOPB45_1401 b146d42d7e5fd2d3e465e8afda73ff56 248 Pfam PF00902 Sec-independent protein translocase protein (TatC) 15 226 1.6E-57 T 13-10-2018 IPR002033 Sec-independent periplasmic protein translocase TatC GO:0016021 TOPB45_1401 b146d42d7e5fd2d3e465e8afda73ff56 248 Hamap MF_00902 Sec-independent protein translocase protein TatC [tatC]. 8 245 15.0 T 13-10-2018 IPR002033 Sec-independent periplasmic protein translocase TatC GO:0016021 TOPB45_1401 b146d42d7e5fd2d3e465e8afda73ff56 248 PRINTS PR01840 Bacterial Sec-independent translocation TatC protein family signature 89 107 1.1E-30 T 13-10-2018 IPR002033 Sec-independent periplasmic protein translocase TatC GO:0016021 TOPB45_1401 b146d42d7e5fd2d3e465e8afda73ff56 248 PRINTS PR01840 Bacterial Sec-independent translocation TatC protein family signature 158 186 1.1E-30 T 13-10-2018 IPR002033 Sec-independent periplasmic protein translocase TatC GO:0016021 TOPB45_1401 b146d42d7e5fd2d3e465e8afda73ff56 248 PRINTS PR01840 Bacterial Sec-independent translocation TatC protein family signature 12 39 1.1E-30 T 13-10-2018 IPR002033 Sec-independent periplasmic protein translocase TatC GO:0016021 TOPB45_1401 b146d42d7e5fd2d3e465e8afda73ff56 248 PRINTS PR01840 Bacterial Sec-independent translocation TatC protein family signature 107 133 1.1E-30 T 13-10-2018 IPR002033 Sec-independent periplasmic protein translocase TatC GO:0016021 TOPB45_1401 b146d42d7e5fd2d3e465e8afda73ff56 248 TIGRFAM TIGR00945 tatC: twin arginine-targeting protein translocase TatC 13 231 1.7E-55 T 13-10-2018 IPR002033 Sec-independent periplasmic protein translocase TatC GO:0016021 TOPB45_1015 f6c38a24c234285bd86efdb0266a7518 281 Gene3D G3DSA:3.40.50.10490 8 219 1.8E-95 T 13-10-2018 TOPB45_1015 f6c38a24c234285bd86efdb0266a7518 281 Gene3D G3DSA:1.10.287.610 103 150 1.8E-95 T 13-10-2018 TOPB45_1015 f6c38a24c234285bd86efdb0266a7518 281 SUPERFAMILY SSF52313 6 231 2.35E-99 T 13-10-2018 IPR023591 Ribosomal protein S2, flavodoxin-like domain superfamily TOPB45_1015 f6c38a24c234285bd86efdb0266a7518 281 PRINTS PR00395 Ribosomal protein S2 signature 37 46 6.0E-40 T 13-10-2018 IPR001865 Ribosomal protein S2 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_1015 f6c38a24c234285bd86efdb0266a7518 281 PRINTS PR00395 Ribosomal protein S2 signature 196 210 6.0E-40 T 13-10-2018 IPR001865 Ribosomal protein S2 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_1015 f6c38a24c234285bd86efdb0266a7518 281 PRINTS PR00395 Ribosomal protein S2 signature 6 24 6.0E-40 T 13-10-2018 IPR001865 Ribosomal protein S2 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_1015 f6c38a24c234285bd86efdb0266a7518 281 PRINTS PR00395 Ribosomal protein S2 signature 175 186 6.0E-40 T 13-10-2018 IPR001865 Ribosomal protein S2 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_1015 f6c38a24c234285bd86efdb0266a7518 281 PRINTS PR00395 Ribosomal protein S2 signature 158 175 6.0E-40 T 13-10-2018 IPR001865 Ribosomal protein S2 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_1015 f6c38a24c234285bd86efdb0266a7518 281 PRINTS PR00395 Ribosomal protein S2 signature 87 104 6.0E-40 T 13-10-2018 IPR001865 Ribosomal protein S2 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_1015 f6c38a24c234285bd86efdb0266a7518 281 ProSitePatterns PS00962 Ribosomal protein S2 signature 1. 6 17 - T 13-10-2018 IPR018130 Ribosomal protein S2, conserved site GO:0003735|GO:0005840|GO:0006412 TOPB45_1015 f6c38a24c234285bd86efdb0266a7518 281 Hamap MF_00291_B 30S ribosomal protein S2 [rpsB]. 2 225 43.579 T 13-10-2018 IPR005706 Ribosomal protein S2, bacteria/mitochondria/plastid GO:0003735|GO:0006412|GO:0015935 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_1015 f6c38a24c234285bd86efdb0266a7518 281 TIGRFAM TIGR01011 rpsB_bact: ribosomal protein uS2 4 225 1.9E-109 T 13-10-2018 IPR005706 Ribosomal protein S2, bacteria/mitochondria/plastid GO:0003735|GO:0006412|GO:0015935 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_1015 f6c38a24c234285bd86efdb0266a7518 281 Pfam PF00318 Ribosomal protein S2 9 224 9.4E-101 T 13-10-2018 IPR001865 Ribosomal protein S2 GO:0003735|GO:0005622|GO:0005840|GO:0006412 TOPB45_0992 94ad2b229b5ce13eed33a9c74a4f1947 499 Gene3D G3DSA:3.40.50.300 13 178 8.8E-104 T 13-10-2018 TOPB45_0992 94ad2b229b5ce13eed33a9c74a4f1947 499 Pfam PF13177 DNA polymerase III, delta subunit 20 179 7.3E-50 T 13-10-2018 TOPB45_0992 94ad2b229b5ce13eed33a9c74a4f1947 499 SMART SM00382 37 180 3.0E-10 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_0992 94ad2b229b5ce13eed33a9c74a4f1947 499 TIGRFAM TIGR02397 dnaX_nterm: DNA polymerase III, subunit gamma and tau 3 354 8.8E-130 T 13-10-2018 IPR012763 DNA polymerase III, subunit gamma/ tau GO:0003887|GO:0005524|GO:0006260|GO:0009360 TOPB45_0992 94ad2b229b5ce13eed33a9c74a4f1947 499 Gene3D G3DSA:1.10.8.60 8 232 8.8E-104 T 13-10-2018 TOPB45_0992 94ad2b229b5ce13eed33a9c74a4f1947 499 Gene3D G3DSA:1.20.272.10 242 359 6.0E-5 T 13-10-2018 TOPB45_0992 94ad2b229b5ce13eed33a9c74a4f1947 499 SUPERFAMILY SSF52540 32 227 1.84E-63 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0992 94ad2b229b5ce13eed33a9c74a4f1947 499 SUPERFAMILY SSF48019 250 362 4.68E-13 T 13-10-2018 IPR008921 DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal GO:0003677|GO:0006260 Reactome: R-HSA-110312|Reactome: R-HSA-110314|Reactome: R-HSA-110320|Reactome: R-HSA-174411|Reactome: R-HSA-5651801|Reactome: R-HSA-5655862|Reactome: R-HSA-5656121|Reactome: R-HSA-5656169|Reactome: R-HSA-5685942|Reactome: R-HSA-5696397|Reactome: R-HSA-5696400|Reactome: R-HSA-6782135|Reactome: R-HSA-6782210|Reactome: R-HSA-69091 TOPB45_0992 94ad2b229b5ce13eed33a9c74a4f1947 499 Pfam PF12169 DNA polymerase III subunits gamma and tau domain III 245 367 8.6E-10 T 13-10-2018 IPR022754 DNA polymerase III, gamma subunit, domain III GO:0003887 TOPB45_0639 c661a7a186a03f3fc0ace3d6925c8206 220 SUPERFAMILY SSF53597 1 213 8.74E-54 T 13-10-2018 IPR024072 Dihydrofolate reductase-like domain superfamily Reactome: R-HSA-196757 TOPB45_0639 c661a7a186a03f3fc0ace3d6925c8206 220 Gene3D G3DSA:3.40.430.10 2 220 6.5E-57 T 13-10-2018 IPR024072 Dihydrofolate reductase-like domain superfamily Reactome: R-HSA-196757 TOPB45_0639 c661a7a186a03f3fc0ace3d6925c8206 220 TIGRFAM TIGR00227 ribD_Cterm: riboflavin-specific deaminase C-terminal domain 3 208 5.8E-53 T 13-10-2018 IPR011549 Riboflavin-specific deaminase, C-terminal GO:0008703|GO:0009231|GO:0050661|GO:0055114 TOPB45_0639 c661a7a186a03f3fc0ace3d6925c8206 220 TIGRFAM TIGR01508 rib_reduct_arch: diaminohydroxyphosphoribosylaminopyrimidine reductase 4 210 3.8E-56 T 13-10-2018 IPR006401 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine 1-reductase, archaeal GO:0016491|GO:0055114 KEGG: 00740+1.1.1.302|MetaCyc: PWY-6167|MetaCyc: PWY-6168 TOPB45_0639 c661a7a186a03f3fc0ace3d6925c8206 220 Pfam PF01872 RibD C-terminal domain 4 210 3.8E-54 T 13-10-2018 IPR002734 Bacterial bifunctional deaminase-reductase, C-terminal GO:0008703|GO:0009231|GO:0055114 TOPB45_0131 695c537d9984b1a8f74d8aa6103ca389 202 SUPERFAMILY SSF53335 18 195 3.72E-38 T 13-10-2018 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TOPB45_0131 695c537d9984b1a8f74d8aa6103ca389 202 Gene3D G3DSA:3.40.50.150 15 199 5.6E-56 T 13-10-2018 TOPB45_0131 695c537d9984b1a8f74d8aa6103ca389 202 PIRSF PIRSF005461 2 202 3.0E-71 T 13-10-2018 IPR015507 Ribosomal RNA large subunit methyltransferase E GO:0001510|GO:0008168 TOPB45_0131 695c537d9984b1a8f74d8aa6103ca389 202 Hamap MF_01547 Ribosomal RNA large subunit methyltransferase E [rlmE]. 3 195 28.193 T 13-10-2018 IPR015507 Ribosomal RNA large subunit methyltransferase E GO:0001510|GO:0008168 TOPB45_0131 695c537d9984b1a8f74d8aa6103ca389 202 Pfam PF01728 FtsJ-like methyltransferase 19 194 1.5E-51 T 13-10-2018 IPR002877 Ribosomal RNA methyltransferase FtsJ domain GO:0008168|GO:0032259 TOPB45_0936 10024e22e85c80f474ad3d0d1ee33fff 286 Hamap MF_01007 Ribosomal RNA small subunit methyltransferase H [rsmH]. 4 286 32.442 T 13-10-2018 IPR002903 Ribosomal RNA small subunit methyltransferase H GO:0008168 TOPB45_0936 10024e22e85c80f474ad3d0d1ee33fff 286 SUPERFAMILY SSF81799 112 208 6.8E-23 T 13-10-2018 IPR023397 S-adenosyl-L-methionine-dependent methyltransferase, MraW, recognition domain superfamily GO:0008168 TOPB45_0936 10024e22e85c80f474ad3d0d1ee33fff 286 Gene3D G3DSA:1.10.150.170 110 210 4.2E-95 T 13-10-2018 IPR023397 S-adenosyl-L-methionine-dependent methyltransferase, MraW, recognition domain superfamily GO:0008168 TOPB45_0936 10024e22e85c80f474ad3d0d1ee33fff 286 SUPERFAMILY SSF53335 3 286 3.25E-39 T 13-10-2018 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TOPB45_0936 10024e22e85c80f474ad3d0d1ee33fff 286 TIGRFAM TIGR00006 TIGR00006: 16S rRNA (cytosine(1402)-N(4))-methyltransferase 2 285 3.4E-87 T 13-10-2018 IPR002903 Ribosomal RNA small subunit methyltransferase H GO:0008168 TOPB45_0936 10024e22e85c80f474ad3d0d1ee33fff 286 PIRSF PIRSF004486 1 286 1.8E-96 T 13-10-2018 IPR002903 Ribosomal RNA small subunit methyltransferase H GO:0008168 TOPB45_0936 10024e22e85c80f474ad3d0d1ee33fff 286 Gene3D G3DSA:3.40.50.150 4 282 4.2E-95 T 13-10-2018 TOPB45_0936 10024e22e85c80f474ad3d0d1ee33fff 286 Pfam PF01795 MraW methylase family 2 286 1.1E-92 T 13-10-2018 IPR002903 Ribosomal RNA small subunit methyltransferase H GO:0008168 TOPB45_1261 bc62c369716e2814882ce13ccfa8c771 398 Pfam PF01548 Transposase 5 153 7.2E-32 T 13-10-2018 IPR002525 Transposase, IS111A/IS1328/IS1533, N-terminal GO:0003677|GO:0004803|GO:0006313 TOPB45_1261 bc62c369716e2814882ce13ccfa8c771 398 Pfam PF02371 Transposase IS116/IS110/IS902 family 265 347 1.9E-22 T 13-10-2018 IPR003346 Transposase, IS116/IS110/IS902 GO:0003677|GO:0004803|GO:0006313 TOPB45_0613 c7f32cd1ea95524b73564c12c645f8bc 287 Pfam PF00535 Glycosyl transferase family 2 7 130 9.0E-35 T 13-10-2018 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 TOPB45_0613 c7f32cd1ea95524b73564c12c645f8bc 287 Gene3D G3DSA:3.90.550.10 1 252 4.8E-66 T 13-10-2018 IPR029044 Nucleotide-diphospho-sugar transferases TOPB45_0613 c7f32cd1ea95524b73564c12c645f8bc 287 SUPERFAMILY SSF53448 4 198 2.6E-62 T 13-10-2018 IPR029044 Nucleotide-diphospho-sugar transferases TOPB45_1024 dd1d7191aae6b952dfca78e9bdf57956 206 SMART SM00749 67 130 1.3E-10 T 13-10-2018 IPR014004 Transport-associated and nodulation domain, bacteria TOPB45_1024 dd1d7191aae6b952dfca78e9bdf57956 206 SMART SM00749 143 206 1.4E-11 T 13-10-2018 IPR014004 Transport-associated and nodulation domain, bacteria TOPB45_1024 dd1d7191aae6b952dfca78e9bdf57956 206 Pfam PF04972 BON domain 138 205 1.1E-19 T 13-10-2018 IPR007055 BON domain TOPB45_1024 dd1d7191aae6b952dfca78e9bdf57956 206 Pfam PF04972 BON domain 62 129 1.4E-19 T 13-10-2018 IPR007055 BON domain TOPB45_0531 ebad0accf818a43820390dd8e982785f 77 Pfam PF13412 Winged helix-turn-helix DNA-binding 21 51 4.3E-5 T 13-10-2018 TOPB45_0531 ebad0accf818a43820390dd8e982785f 77 Gene3D G3DSA:1.10.10.10 16 61 1.5E-6 T 13-10-2018 IPR036388 Winged helix-like DNA-binding domain superfamily TOPB45_0919 f6a6e1e43d392d553b54103b840b8967 304 Gene3D G3DSA:3.40.50.300 39 198 5.6E-16 T 13-10-2018 TOPB45_0919 f6a6e1e43d392d553b54103b840b8967 304 SMART SM00382 54 195 2.5E-5 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_0919 f6a6e1e43d392d553b54103b840b8967 304 Pfam PF13401 AAA domain 54 183 5.0E-21 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_0919 f6a6e1e43d392d553b54103b840b8967 304 SUPERFAMILY SSF52540 17 276 1.95E-30 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1608 a65075d34c71fbd984c66a7b21680cd3 256 Pfam PF02591 C4-type zinc ribbon domain 198 229 1.4E-11 T 13-10-2018 IPR003743 C4-type zinc ribbon domain TOPB45_0799 3f52a26634e36daef6ceb189d32318b7 290 Pfam PF01925 Sulfite exporter TauE/SafE 23 283 3.4E-37 T 13-10-2018 IPR002781 Transmembrane protein TauE-like GO:0016021 TOPB45_0186 aba451c46f047ebe86eb2355f58e59c6 281 SUPERFAMILY SSF52402 147 280 4.02E-25 T 13-10-2018 TOPB45_0186 aba451c46f047ebe86eb2355f58e59c6 281 PRINTS PR01438 Universal stress protein signature 118 140 5.9E-19 T 13-10-2018 IPR006015 Universal stress protein A TOPB45_0186 aba451c46f047ebe86eb2355f58e59c6 281 PRINTS PR01438 Universal stress protein signature 100 112 5.9E-19 T 13-10-2018 IPR006015 Universal stress protein A TOPB45_0186 aba451c46f047ebe86eb2355f58e59c6 281 PRINTS PR01438 Universal stress protein signature 2 20 5.9E-19 T 13-10-2018 IPR006015 Universal stress protein A TOPB45_0186 aba451c46f047ebe86eb2355f58e59c6 281 SUPERFAMILY SSF52402 2 140 4.29E-38 T 13-10-2018 TOPB45_0186 aba451c46f047ebe86eb2355f58e59c6 281 Gene3D G3DSA:3.40.50.620 1 140 9.2E-41 T 13-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TOPB45_0186 aba451c46f047ebe86eb2355f58e59c6 281 Gene3D G3DSA:3.40.50.620 144 281 3.7E-26 T 13-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TOPB45_0186 aba451c46f047ebe86eb2355f58e59c6 281 Pfam PF00582 Universal stress protein family 1 140 9.7E-36 T 13-10-2018 IPR006016 UspA TOPB45_0186 aba451c46f047ebe86eb2355f58e59c6 281 Pfam PF00582 Universal stress protein family 147 280 1.5E-22 T 13-10-2018 IPR006016 UspA TOPB45_1375 b782262a9f5031eebe224450a1fa67ba 385 TIGRFAM TIGR00230 sfsA: sugar fermentation stimulation protein 10 220 9.6E-49 T 13-10-2018 IPR005224 Sugar fermentation stimulation protein TOPB45_1375 b782262a9f5031eebe224450a1fa67ba 385 Pfam PF01986 Domain of unknown function DUF123 269 355 1.0E-25 T 13-10-2018 IPR002837 Protein of unknown function DUF123 TOPB45_1375 b782262a9f5031eebe224450a1fa67ba 385 Gene3D G3DSA:2.40.50.580 8 81 2.0E-17 T 13-10-2018 TOPB45_1375 b782262a9f5031eebe224450a1fa67ba 385 SMART SM00465 247 357 2.0E-9 T 13-10-2018 IPR000305 GIY-YIG endonuclease TOPB45_1375 b782262a9f5031eebe224450a1fa67ba 385 Pfam PF03749 Sugar fermentation stimulation protein 17 219 6.6E-49 T 13-10-2018 IPR005224 Sugar fermentation stimulation protein TOPB45_1375 b782262a9f5031eebe224450a1fa67ba 385 Gene3D G3DSA:3.40.1350.60 82 232 7.6E-37 T 13-10-2018 TOPB45_0864 060a18c8fe7e97e4d83bf5e1b5884db1 355 SUPERFAMILY SSF56300 1 275 7.74E-41 T 13-10-2018 TOPB45_0864 060a18c8fe7e97e4d83bf5e1b5884db1 355 Gene3D G3DSA:3.60.21.10 1 232 2.7E-38 T 13-10-2018 IPR029052 Metallo-dependent phosphatase-like TOPB45_0864 060a18c8fe7e97e4d83bf5e1b5884db1 355 Pfam PF00149 Calcineurin-like phosphoesterase 1 186 2.0E-16 T 13-10-2018 IPR004843 Calcineurin-like phosphoesterase domain, ApaH type GO:0016787 TOPB45_0759 a93e8703e77b618df17b32e3f02ac81e 220 SUPERFAMILY SSF54821 109 207 1.31E-40 T 13-10-2018 IPR036419 Ribosomal protein S3, C-terminal domain superfamily GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0759 a93e8703e77b618df17b32e3f02ac81e 220 Hamap MF_01309_B 30S ribosomal protein S3 [rpsC]. 1 207 38.833 T 13-10-2018 IPR005704 Ribosomal protein S3, bacterial GO:0003735|GO:0006412|GO:0015935 TOPB45_0759 a93e8703e77b618df17b32e3f02ac81e 220 Pfam PF07650 KH domain 39 112 1.6E-17 T 13-10-2018 IPR004044 K Homology domain, type 2 GO:0003723 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0759 a93e8703e77b618df17b32e3f02ac81e 220 SUPERFAMILY SSF54814 2 103 1.31E-36 T 13-10-2018 IPR009019 K homology domain superfamily, prokaryotic type GO:0003723 TOPB45_0759 a93e8703e77b618df17b32e3f02ac81e 220 Pfam PF00189 Ribosomal protein S3, C-terminal domain 121 203 2.9E-38 T 13-10-2018 IPR001351 Ribosomal protein S3, C-terminal GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0759 a93e8703e77b618df17b32e3f02ac81e 220 TIGRFAM TIGR01009 rpsC_bact: ribosomal protein uS3 1 210 8.4E-95 T 13-10-2018 IPR005704 Ribosomal protein S3, bacterial GO:0003735|GO:0006412|GO:0015935 TOPB45_0759 a93e8703e77b618df17b32e3f02ac81e 220 ProSitePatterns PS00548 Ribosomal protein S3 signature. 164 198 - T 13-10-2018 IPR018280 Ribosomal protein S3, conserved site Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0759 a93e8703e77b618df17b32e3f02ac81e 220 SMART SM00322 60 126 1.5E-5 T 13-10-2018 IPR004087 K Homology domain GO:0003676 TOPB45_0759 a93e8703e77b618df17b32e3f02ac81e 220 Gene3D G3DSA:3.30.300.20 17 108 1.3E-30 T 13-10-2018 IPR015946 K homology domain-like, alpha/beta TOPB45_0759 a93e8703e77b618df17b32e3f02ac81e 220 Gene3D G3DSA:3.30.1140.32 109 209 1.4E-42 T 13-10-2018 IPR036419 Ribosomal protein S3, C-terminal domain superfamily GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_1372 ab041988f204f65926b8d0c334d15944 364 SUPERFAMILY SSF102114 141 344 2.94E-16 T 13-10-2018 TOPB45_1372 ab041988f204f65926b8d0c334d15944 364 PIRSF PIRSF004869 5 364 1.4E-80 T 13-10-2018 IPR016431 Pyruvate-formate lyase-activating enzyme, predicted TOPB45_1372 ab041988f204f65926b8d0c334d15944 364 Gene3D G3DSA:3.20.20.70 132 355 8.7E-27 T 13-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 TOPB45_1372 ab041988f204f65926b8d0c334d15944 364 Pfam PF13353 4Fe-4S single cluster domain 139 231 1.4E-5 T 13-10-2018 TOPB45_1372 ab041988f204f65926b8d0c334d15944 364 Pfam PF04055 Radical SAM superfamily 141 298 4.1E-12 T 13-10-2018 IPR007197 Radical SAM GO:0003824|GO:0051536 TOPB45_1595 2e079c11002af1b6fae600d80666f137 263 Gene3D G3DSA:3.60.21.10 5 262 6.7E-104 T 13-10-2018 IPR029052 Metallo-dependent phosphatase-like TOPB45_1595 2e079c11002af1b6fae600d80666f137 263 TIGRFAM TIGR00282 TIGR00282: metallophosphoesterase, MG_246/BB_0505 family 5 258 2.1E-86 T 13-10-2018 IPR005235 Metallophosphoesterase, YmdB-like TOPB45_1595 2e079c11002af1b6fae600d80666f137 263 PIRSF PIRSF004789 4 262 3.6E-94 T 13-10-2018 IPR005235 Metallophosphoesterase, YmdB-like TOPB45_1595 2e079c11002af1b6fae600d80666f137 263 Pfam PF13277 YmdB-like protein 8 256 2.3E-99 T 13-10-2018 IPR005235 Metallophosphoesterase, YmdB-like TOPB45_1595 2e079c11002af1b6fae600d80666f137 263 SUPERFAMILY SSF56300 5 248 3.07E-71 T 13-10-2018 TOPB45_0335 2fc137ff79c5591acc0ee19f2926570e 141 SUPERFAMILY SSF88723 1 132 1.46E-22 T 13-10-2018 IPR029060 PIN-like domain superfamily TOPB45_0335 2fc137ff79c5591acc0ee19f2926570e 141 Pfam PF01850 PIN domain 3 121 9.3E-17 T 13-10-2018 IPR002716 PIN domain TOPB45_0335 2fc137ff79c5591acc0ee19f2926570e 141 Gene3D G3DSA:3.40.50.1010 2 139 4.0E-16 T 13-10-2018 TOPB45_1030 f5565658a0464d4a18e9311865cd85fd 240 Pfam PF00881 Nitroreductase family 62 240 3.6E-23 T 13-10-2018 IPR029479 Nitroreductase Reactome: R-HSA-209968 TOPB45_1030 f5565658a0464d4a18e9311865cd85fd 240 SUPERFAMILY SSF55469 56 240 1.08E-28 T 13-10-2018 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 TOPB45_1030 f5565658a0464d4a18e9311865cd85fd 240 Gene3D G3DSA:3.40.109.10 12 240 4.5E-63 T 13-10-2018 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 TOPB45_1030 f5565658a0464d4a18e9311865cd85fd 240 TIGRFAM TIGR03605 antibiot_sagB: SagB-type dehydrogenase domain 77 240 3.5E-33 T 13-10-2018 IPR020051 SagB-type dehydrogenase domain TOPB45_0728 7f52aec06200fb5fc3731c847edbc9be 273 Gene3D G3DSA:3.30.950.10 162 272 1.3E-12 T 13-10-2018 IPR014776 Tetrapyrrole methylase, subdomain 2 GO:0008168 Reactome: R-HSA-5358493 TOPB45_0728 7f52aec06200fb5fc3731c847edbc9be 273 Pfam PF00590 Tetrapyrrole (Corrin/Porphyrin) Methylases 27 250 6.4E-39 T 13-10-2018 IPR000878 Tetrapyrrole methylase GO:0008168 Reactome: R-HSA-5358493 TOPB45_0728 7f52aec06200fb5fc3731c847edbc9be 273 Gene3D G3DSA:3.40.1010.10 24 161 8.9E-29 T 13-10-2018 IPR014777 Tetrapyrrole methylase, subdomain 1 GO:0008168 Reactome: R-HSA-5358493 TOPB45_0728 7f52aec06200fb5fc3731c847edbc9be 273 SUPERFAMILY SSF53790 24 270 1.19E-41 T 13-10-2018 IPR035996 Tetrapyrrole methylase superfamily GO:0008168 Reactome: R-HSA-5358493 TOPB45_0387 755653bef2c5a7246d3e922a55d2d0cb 365 SUPERFAMILY SSF56014 265 358 1.96E-12 T 13-10-2018 TOPB45_0387 755653bef2c5a7246d3e922a55d2d0cb 365 Hamap MF_00159 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin) [ispG]. 5 356 32.081 T 13-10-2018 IPR004588 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial-type GO:0016114|GO:0046429|GO:0055114 KEGG: 00900+1.17.7.3 TOPB45_0387 755653bef2c5a7246d3e922a55d2d0cb 365 Gene3D G3DSA:3.30.413.10 262 360 2.3E-34 T 13-10-2018 TOPB45_0387 755653bef2c5a7246d3e922a55d2d0cb 365 TIGRFAM TIGR00612 ispG_gcpE: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 7 351 4.9E-125 T 13-10-2018 IPR004588 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial-type GO:0016114|GO:0046429|GO:0055114 KEGG: 00900+1.17.7.3 TOPB45_0387 755653bef2c5a7246d3e922a55d2d0cb 365 SUPERFAMILY SSF51717 14 208 8.63E-8 T 13-10-2018 IPR011005 Dihydropteroate synthase-like GO:0044237 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 TOPB45_0387 755653bef2c5a7246d3e922a55d2d0cb 365 Gene3D G3DSA:3.20.20.20 2 260 4.6E-101 T 13-10-2018 IPR011005 Dihydropteroate synthase-like GO:0044237 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 TOPB45_0387 755653bef2c5a7246d3e922a55d2d0cb 365 Pfam PF04551 GcpE protein 10 352 1.7E-130 T 13-10-2018 IPR004588 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial-type GO:0016114|GO:0046429|GO:0055114 KEGG: 00900+1.17.7.3 TOPB45_0387 755653bef2c5a7246d3e922a55d2d0cb 365 PIRSF PIRSF004640 1 361 2.4E-142 T 13-10-2018 IPR016425 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial GO:0005506|GO:0008299|GO:0046429|GO:0055114 KEGG: 00900+1.17.7.3 TOPB45_0757 26d99057c88d8a870651325aaa328803 96 SUPERFAMILY SSF54570 3 84 2.88E-36 T 13-10-2018 IPR023575 Ribosomal protein S19, superfamily GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0757 26d99057c88d8a870651325aaa328803 96 PIRSF PIRSF002144 1 96 1.0E-33 T 13-10-2018 IPR002222 Ribosomal protein S19/S15 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0757 26d99057c88d8a870651325aaa328803 96 PRINTS PR00975 Ribosomal protein S19 family signature 53 65 5.3E-24 T 13-10-2018 IPR002222 Ribosomal protein S19/S15 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0757 26d99057c88d8a870651325aaa328803 96 PRINTS PR00975 Ribosomal protein S19 family signature 33 52 5.3E-24 T 13-10-2018 IPR002222 Ribosomal protein S19/S15 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0757 26d99057c88d8a870651325aaa328803 96 PRINTS PR00975 Ribosomal protein S19 family signature 65 80 5.3E-24 T 13-10-2018 IPR002222 Ribosomal protein S19/S15 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0757 26d99057c88d8a870651325aaa328803 96 Gene3D G3DSA:3.30.860.10 1 92 6.9E-42 T 13-10-2018 IPR023575 Ribosomal protein S19, superfamily GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0757 26d99057c88d8a870651325aaa328803 96 Hamap MF_00531 30S ribosomal protein S19 [rpsS]. 1 89 25.494 T 13-10-2018 IPR002222 Ribosomal protein S19/S15 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0757 26d99057c88d8a870651325aaa328803 96 TIGRFAM TIGR01050 rpsS_bact: ribosomal protein uS19 1 88 5.7E-46 T 13-10-2018 IPR005732 Ribosomal protein S19, bacterial-type GO:0003735|GO:0006412|GO:0015935 TOPB45_0757 26d99057c88d8a870651325aaa328803 96 Pfam PF00203 Ribosomal protein S19 3 83 2.4E-38 T 13-10-2018 IPR002222 Ribosomal protein S19/S15 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_0757 26d99057c88d8a870651325aaa328803 96 ProSitePatterns PS00323 Ribosomal protein S19 signature. 53 77 - T 13-10-2018 IPR020934 Ribosomal protein S19 conserved site GO:0003723 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-9010553|Reactome: R-HSA-975956|Reactome: R-HSA-975957 TOPB45_1187 e4c365383e3e1798a34f4ff62bb13b6c 291 Pfam PF04468 PSP1 C-terminal conserved region 69 152 2.0E-24 T 13-10-2018 IPR007557 PSP1, C-terminal TOPB45_0540 8454c6266066d6d044ef6cebf0dd41fb 53 ProSitePatterns PS00202 Rubredoxin signature. 33 43 - T 13-10-2018 IPR018527 Rubredoxin, iron-binding site GO:0046872 TOPB45_0540 8454c6266066d6d044ef6cebf0dd41fb 53 PRINTS PR00163 Rubredoxin signature 33 49 5.8E-10 T 13-10-2018 IPR024935 Rubredoxin domain GO:0005506 TOPB45_0540 8454c6266066d6d044ef6cebf0dd41fb 53 PRINTS PR00163 Rubredoxin signature 3 19 5.8E-10 T 13-10-2018 IPR024935 Rubredoxin domain GO:0005506 TOPB45_0540 8454c6266066d6d044ef6cebf0dd41fb 53 SUPERFAMILY SSF57802 1 51 2.36E-21 T 13-10-2018 TOPB45_0540 8454c6266066d6d044ef6cebf0dd41fb 53 PIRSF PIRSF000071 1 53 6.7E-26 T 13-10-2018 IPR024922 Rubredoxin GO:0005506|GO:0009055 TOPB45_0540 8454c6266066d6d044ef6cebf0dd41fb 53 Gene3D G3DSA:2.20.28.10 1 52 2.3E-24 T 13-10-2018 TOPB45_0540 8454c6266066d6d044ef6cebf0dd41fb 53 Pfam PF00301 Rubredoxin 3 49 3.4E-22 T 13-10-2018 IPR024935 Rubredoxin domain GO:0005506 TOPB45_1042 1f756d6c40d5375ca8f344c2ed6a2bd1 478 Gene3D G3DSA:3.40.1380.20 336 465 7.5E-169 T 13-10-2018 IPR036918 Pyruvate kinase, C-terminal domain superfamily KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 TOPB45_1042 1f756d6c40d5375ca8f344c2ed6a2bd1 478 SUPERFAMILY SSF51621 1 340 1.5E-95 T 13-10-2018 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily GO:0003824 TOPB45_1042 1f756d6c40d5375ca8f344c2ed6a2bd1 478 Gene3D G3DSA:2.40.33.10 70 169 7.5E-169 T 13-10-2018 IPR015806 Pyruvate kinase, insert domain superfamily GO:0004743|GO:0006096 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 TOPB45_1042 1f756d6c40d5375ca8f344c2ed6a2bd1 478 Pfam PF00224 Pyruvate kinase, barrel domain 1 339 4.1E-120 T 13-10-2018 IPR015793 Pyruvate kinase, barrel GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 TOPB45_1042 1f756d6c40d5375ca8f344c2ed6a2bd1 478 TIGRFAM TIGR01064 pyruv_kin: pyruvate kinase 2 467 3.6E-158 T 13-10-2018 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 TOPB45_1042 1f756d6c40d5375ca8f344c2ed6a2bd1 478 SUPERFAMILY SSF52935 323 467 9.81E-36 T 13-10-2018 IPR036918 Pyruvate kinase, C-terminal domain superfamily KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 TOPB45_1042 1f756d6c40d5375ca8f344c2ed6a2bd1 478 PRINTS PR01050 Pyruvate kinase family signature 187 201 9.5E-63 T 13-10-2018 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 TOPB45_1042 1f756d6c40d5375ca8f344c2ed6a2bd1 478 PRINTS PR01050 Pyruvate kinase family signature 313 329 9.5E-63 T 13-10-2018 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 TOPB45_1042 1f756d6c40d5375ca8f344c2ed6a2bd1 478 PRINTS PR01050 Pyruvate kinase family signature 59 75 9.5E-63 T 13-10-2018 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 TOPB45_1042 1f756d6c40d5375ca8f344c2ed6a2bd1 478 PRINTS PR01050 Pyruvate kinase family signature 217 243 9.5E-63 T 13-10-2018 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 TOPB45_1042 1f756d6c40d5375ca8f344c2ed6a2bd1 478 PRINTS PR01050 Pyruvate kinase family signature 294 312 9.5E-63 T 13-10-2018 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 TOPB45_1042 1f756d6c40d5375ca8f344c2ed6a2bd1 478 PRINTS PR01050 Pyruvate kinase family signature 244 268 9.5E-63 T 13-10-2018 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 TOPB45_1042 1f756d6c40d5375ca8f344c2ed6a2bd1 478 PRINTS PR01050 Pyruvate kinase family signature 269 293 9.5E-63 T 13-10-2018 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 TOPB45_1042 1f756d6c40d5375ca8f344c2ed6a2bd1 478 Gene3D G3DSA:3.20.20.60 2 335 7.5E-169 T 13-10-2018 TOPB45_1042 1f756d6c40d5375ca8f344c2ed6a2bd1 478 SUPERFAMILY SSF50800 70 167 1.15E-20 T 13-10-2018 IPR011037 Pyruvate kinase-like, insert domain superfamily TOPB45_1042 1f756d6c40d5375ca8f344c2ed6a2bd1 478 Pfam PF02887 Pyruvate kinase, alpha/beta domain 354 467 2.4E-30 T 13-10-2018 IPR015795 Pyruvate kinase, C-terminal KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 TOPB45_0658 5dc35298fbe96cee68e40e998a0e5b57 422 PIRSF PIRSF033563 1 410 4.7E-80 T 13-10-2018 IPR008323 Uncharacterised conserved protein UCP033563 TOPB45_0658 5dc35298fbe96cee68e40e998a0e5b57 422 Pfam PF06245 Protein of unknown function (DUF1015) 5 407 2.1E-98 T 13-10-2018 IPR008323 Uncharacterised conserved protein UCP033563 TOPB45_1071 35ab9dafcdd41e6ae84da3d8801cdaaa 423 Pfam PF02321 Outer membrane efflux protein 236 416 5.8E-34 T 13-10-2018 IPR003423 Outer membrane efflux protein GO:0015562|GO:0055085 TOPB45_1071 35ab9dafcdd41e6ae84da3d8801cdaaa 423 Pfam PF02321 Outer membrane efflux protein 28 211 4.1E-29 T 13-10-2018 IPR003423 Outer membrane efflux protein GO:0015562|GO:0055085 TOPB45_1071 35ab9dafcdd41e6ae84da3d8801cdaaa 423 Gene3D G3DSA:1.20.1600.10 22 417 3.1E-70 T 13-10-2018 TOPB45_1071 35ab9dafcdd41e6ae84da3d8801cdaaa 423 SUPERFAMILY SSF56954 2 417 5.23E-72 T 13-10-2018 TOPB45_0351 e631c68d3fced07b78487073703ca029 295 TIGRFAM TIGR01207 rmlA: glucose-1-phosphate thymidylyltransferase 6 293 3.5E-124 T 13-10-2018 IPR005907 Glucose-1-phosphate thymidylyltransferase, short form GO:0008879|GO:0045226 KEGG: 00521+2.7.7.24|KEGG: 00523+2.7.7.24|KEGG: 00525+2.7.7.24|MetaCyc: PWY-3221|MetaCyc: PWY-6808|MetaCyc: PWY-6942|MetaCyc: PWY-6953|MetaCyc: PWY-6973|MetaCyc: PWY-6974|MetaCyc: PWY-6976|MetaCyc: PWY-7104|MetaCyc: PWY-7301|MetaCyc: PWY-7312|MetaCyc: PWY-7315|MetaCyc: PWY-7316|MetaCyc: PWY-7318|MetaCyc: PWY-7413|MetaCyc: PWY-7414|MetaCyc: PWY-7440|MetaCyc: PWY-7657|MetaCyc: PWY-7688|MetaCyc: PWY-7814 TOPB45_0351 e631c68d3fced07b78487073703ca029 295 Pfam PF00483 Nucleotidyl transferase 6 245 7.4E-62 T 13-10-2018 IPR005835 Nucleotidyl transferase domain GO:0009058|GO:0016779 TOPB45_0351 e631c68d3fced07b78487073703ca029 295 SUPERFAMILY SSF53448 5 293 5.42E-83 T 13-10-2018 IPR029044 Nucleotide-diphospho-sugar transferases TOPB45_0351 e631c68d3fced07b78487073703ca029 295 Gene3D G3DSA:3.90.550.10 3 295 1.6E-83 T 13-10-2018 IPR029044 Nucleotide-diphospho-sugar transferases TOPB45_0223 c0bf458668fa1c8620408ddafdb30daa 408 SUPERFAMILY SSF102114 55 289 5.62E-18 T 13-10-2018 TOPB45_0223 c0bf458668fa1c8620408ddafdb30daa 408 Gene3D G3DSA:1.10.150.320 311 368 1.2E-5 T 13-10-2018 TOPB45_0223 c0bf458668fa1c8620408ddafdb30daa 408 SUPERFAMILY SSF47781 296 376 5.23E-11 T 13-10-2018 IPR010994 RuvA domain 2-like TOPB45_0223 c0bf458668fa1c8620408ddafdb30daa 408 Gene3D G3DSA:3.20.20.70 61 257 3.5E-11 T 13-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 TOPB45_0223 c0bf458668fa1c8620408ddafdb30daa 408 Pfam PF04055 Radical SAM superfamily 71 207 4.9E-8 T 13-10-2018 IPR007197 Radical SAM GO:0003824|GO:0051536 TOPB45_0223 c0bf458668fa1c8620408ddafdb30daa 408 TIGRFAM TIGR03916 rSAM_link_UDG: putative DNA modification/repair radical SAM protein 16 390 6.9E-154 T 13-10-2018 IPR023874 DNA modification/repair radical SAM protein, putative TOPB45_1314 0abc3e5bc0045067b28c289a845f2b2d 264 Pfam PF10670 Domain of unknown function (DUF4198) 22 232 8.1E-51 T 13-10-2018 IPR019613 Protein of unknown function DUF4198 TOPB45_0685 9f2ae6e916a9ba26e8aac5b0c9a61b3b 670 Pfam PF01580 FtsK/SpoIIIE family 318 454 6.9E-48 T 13-10-2018 IPR002543 FtsK domain GO:0000166|GO:0003677|GO:0005524 TOPB45_0685 9f2ae6e916a9ba26e8aac5b0c9a61b3b 670 Pfam PF13491 4TM region of DNA translocase FtsK/SpoIIIE 4 160 1.8E-19 T 13-10-2018 IPR025199 DNA translocase FtsK, 4TM region TOPB45_0685 9f2ae6e916a9ba26e8aac5b0c9a61b3b 670 SUPERFAMILY SSF46785 604 667 1.86E-20 T 13-10-2018 IPR036390 Winged helix DNA-binding domain superfamily TOPB45_0685 9f2ae6e916a9ba26e8aac5b0c9a61b3b 670 Gene3D G3DSA:1.10.10.10 600 664 5.7E-25 T 13-10-2018 IPR036388 Winged helix-like DNA-binding domain superfamily TOPB45_0685 9f2ae6e916a9ba26e8aac5b0c9a61b3b 670 SUPERFAMILY SSF52540 290 576 4.04E-47 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0685 9f2ae6e916a9ba26e8aac5b0c9a61b3b 670 Gene3D G3DSA:3.30.980.40 210 314 2.8E-33 T 13-10-2018 TOPB45_0685 9f2ae6e916a9ba26e8aac5b0c9a61b3b 670 SMART SM00843 603 668 3.6E-32 T 13-10-2018 IPR018541 FtsK gamma domain TOPB45_0685 9f2ae6e916a9ba26e8aac5b0c9a61b3b 670 Pfam PF09397 Ftsk gamma domain 606 664 3.9E-26 T 13-10-2018 IPR018541 FtsK gamma domain TOPB45_0685 9f2ae6e916a9ba26e8aac5b0c9a61b3b 670 SMART SM00382 353 520 4.1E-4 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_0685 9f2ae6e916a9ba26e8aac5b0c9a61b3b 670 Gene3D G3DSA:3.40.50.300 315 589 1.0E-106 T 13-10-2018 TOPB45_0231 bdd12451faf6731809d56bdb0046b9ce 274 Gene3D G3DSA:2.30.140.10 2 52 4.2E-10 T 13-10-2018 IPR037163 Spermidine synthase, tetramerisation domain superfamily KEGG: 00270+2.5.1.16|KEGG: 00330+2.5.1.16|KEGG: 00410+2.5.1.16|KEGG: 00480+2.5.1.16|Reactome: R-HSA-351202 TOPB45_0231 bdd12451faf6731809d56bdb0046b9ce 274 ProSitePatterns PS01330 Polyamine biosynthesis (PABS) domain signature. 80 93 - T 13-10-2018 IPR030373 Polyamine biosynthesis domain, conserved site KEGG: 00270+2.5.1.16|KEGG: 00330+2.5.1.16|KEGG: 00410+2.5.1.16|KEGG: 00480+2.5.1.16|Reactome: R-HSA-351202 TOPB45_0231 bdd12451faf6731809d56bdb0046b9ce 274 Pfam PF17284 Spermidine synthase tetramerisation domain 6 55 2.4E-8 T 13-10-2018 IPR035246 Spermidine synthase, tetramerisation domain KEGG: 00270+2.5.1.16|KEGG: 00330+2.5.1.16|KEGG: 00410+2.5.1.16|KEGG: 00480+2.5.1.16|Reactome: R-HSA-351202 TOPB45_0231 bdd12451faf6731809d56bdb0046b9ce 274 Gene3D G3DSA:3.40.50.150 57 273 8.9E-56 T 13-10-2018 TOPB45_0231 bdd12451faf6731809d56bdb0046b9ce 274 Hamap MF_00198 Polyamine aminopropyltransferase [speE]. 5 273 31.565 T 13-10-2018 IPR001045 Spermidine/spermine synthases GO:0003824 KEGG: 00270+2.5.1.16|KEGG: 00330+2.5.1.16|KEGG: 00410+2.5.1.16|KEGG: 00480+2.5.1.16|Reactome: R-HSA-351202 TOPB45_0231 bdd12451faf6731809d56bdb0046b9ce 274 SUPERFAMILY SSF53335 2 273 1.25E-65 T 13-10-2018 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TOPB45_0231 bdd12451faf6731809d56bdb0046b9ce 274 Pfam PF01564 Spermine/spermidine synthase domain 58 235 2.9E-43 T 13-10-2018 TOPB45_0906 7d5cfefb0ae8a4af1fb486bd6c971d8a 359 SMART SM01329 7 349 2.0E-169 T 13-10-2018 IPR024084 Isopropylmalate dehydrogenase-like domain GO:0016616|GO:0055114 Reactome: R-HSA-71403 TOPB45_0906 7d5cfefb0ae8a4af1fb486bd6c971d8a 359 Pfam PF00180 Isocitrate/isopropylmalate dehydrogenase 7 348 2.9E-91 T 13-10-2018 IPR024084 Isopropylmalate dehydrogenase-like domain GO:0016616|GO:0055114 Reactome: R-HSA-71403 TOPB45_0906 7d5cfefb0ae8a4af1fb486bd6c971d8a 359 Gene3D G3DSA:3.40.718.10 1 357 7.3E-130 T 13-10-2018 TOPB45_0906 7d5cfefb0ae8a4af1fb486bd6c971d8a 359 ProSitePatterns PS00470 Isocitrate and isopropylmalate dehydrogenases signature. 244 263 - T 13-10-2018 IPR019818 Isocitrate/isopropylmalate dehydrogenase, conserved site GO:0000287|GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-71403 TOPB45_0906 7d5cfefb0ae8a4af1fb486bd6c971d8a 359 SUPERFAMILY SSF53659 4 352 2.67E-118 T 13-10-2018 TOPB45_0465 f9fc0a39da57283aa62b293189098beb 113 PIRSF PIRSF004761 1 113 5.1E-30 T 13-10-2018 IPR000688 Hydrogenase maturation factor HypA/HybF GO:0016151|GO:0051604 TOPB45_0465 f9fc0a39da57283aa62b293189098beb 113 Gene3D G3DSA:3.30.2320.80 1 113 2.7E-30 T 13-10-2018 TOPB45_0465 f9fc0a39da57283aa62b293189098beb 113 Pfam PF01155 Hydrogenase/urease nickel incorporation, metallochaperone, hypA 1 111 1.9E-27 T 13-10-2018 IPR000688 Hydrogenase maturation factor HypA/HybF GO:0016151|GO:0051604 TOPB45_0465 f9fc0a39da57283aa62b293189098beb 113 ProSitePatterns PS01249 Hydrogenases expression/synthesis hypA family signature. 34 76 - T 13-10-2018 IPR020538 Hydrogenase nickel incorporation protein HypA/HybF, conserved site TOPB45_0465 f9fc0a39da57283aa62b293189098beb 113 Hamap MF_00213 Hydrogenase maturation factor HypA [hypA]. 1 113 19.301 T 13-10-2018 IPR000688 Hydrogenase maturation factor HypA/HybF GO:0016151|GO:0051604 TOPB45_0561 9360a42e6407e53dca26bd2d587ed4f5 489 Pfam PF01977 3-octaprenyl-4-hydroxybenzoate carboxy-lyase 11 424 8.7E-167 T 13-10-2018 IPR002830 UbiD decarboxylyase family GO:0016831 KEGG: 00130+4.1.1.98|MetaCyc: PWY-5855|MetaCyc: PWY-5856|MetaCyc: PWY-5857|MetaCyc: PWY-6708|MetaCyc: PWY-6978 TOPB45_0561 9360a42e6407e53dca26bd2d587ed4f5 489 SUPERFAMILY SSF143968 319 482 1.83E-57 T 13-10-2018 TOPB45_0561 9360a42e6407e53dca26bd2d587ed4f5 489 SUPERFAMILY SSF50475 4 318 4.71E-123 T 13-10-2018 TOPB45_0561 9360a42e6407e53dca26bd2d587ed4f5 489 TIGRFAM TIGR03701 mena_SCO4490: menaquinone biosynthesis decarboxylase, SCO4490 family 9 441 7.0E-202 T 13-10-2018 IPR022390 4-hydroxybenzoate decarboxylase subunit C GO:0016831 TOPB45_0561 9360a42e6407e53dca26bd2d587ed4f5 489 Gene3D G3DSA:3.40.1670.10 333 448 4.4E-36 T 13-10-2018 TOPB45_0561 9360a42e6407e53dca26bd2d587ed4f5 489 TIGRFAM TIGR00148 TIGR00148: decarboxylase, UbiD family 7 449 1.6E-152 T 13-10-2018 IPR002830 UbiD decarboxylyase family GO:0016831 KEGG: 00130+4.1.1.98|MetaCyc: PWY-5855|MetaCyc: PWY-5856|MetaCyc: PWY-5857|MetaCyc: PWY-6708|MetaCyc: PWY-6978 TOPB45_1454 bb56abee6155f315f3ffecedbc0c31c9 164 Gene3D G3DSA:3.30.428.10 1 163 3.1E-49 T 13-10-2018 IPR036265 HIT-like superfamily TOPB45_1454 bb56abee6155f315f3ffecedbc0c31c9 164 SUPERFAMILY SSF54197 3 152 1.7E-39 T 13-10-2018 IPR036265 HIT-like superfamily TOPB45_1454 bb56abee6155f315f3ffecedbc0c31c9 164 Pfam PF01230 HIT domain 37 127 6.5E-15 T 13-10-2018 IPR001310 Histidine triad (HIT) protein TOPB45_0158 1682b0c190cb87b3c80b9ed3417ea1a6 194 Gene3D G3DSA:3.40.50.300 1 194 3.9E-55 T 13-10-2018 TOPB45_0158 1682b0c190cb87b3c80b9ed3417ea1a6 194 SUPERFAMILY SSF52540 1 190 4.69E-28 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0158 1682b0c190cb87b3c80b9ed3417ea1a6 194 Hamap MF_00376 Dephospho-CoA kinase [coaE]. 1 194 21.632 T 13-10-2018 IPR001977 Dephospho-CoA kinase GO:0004140|GO:0005524|GO:0015937 KEGG: 00770+2.7.1.24|MetaCyc: PWY-7851 TOPB45_0158 1682b0c190cb87b3c80b9ed3417ea1a6 194 Pfam PF01121 Dephospho-CoA kinase 4 178 4.9E-35 T 13-10-2018 IPR001977 Dephospho-CoA kinase GO:0004140|GO:0005524|GO:0015937 KEGG: 00770+2.7.1.24|MetaCyc: PWY-7851 TOPB45_0158 1682b0c190cb87b3c80b9ed3417ea1a6 194 TIGRFAM TIGR00152 TIGR00152: dephospho-CoA kinase 4 186 4.7E-41 T 13-10-2018 IPR001977 Dephospho-CoA kinase GO:0004140|GO:0005524|GO:0015937 KEGG: 00770+2.7.1.24|MetaCyc: PWY-7851 TOPB45_1471 45beec2b30a8bc45fdfe2b2d6b252c6f 254 SUPERFAMILY SSF53067 124 252 3.08E-37 T 13-10-2018 TOPB45_1471 45beec2b30a8bc45fdfe2b2d6b252c6f 254 Gene3D G3DSA:3.30.420.40 91 254 1.8E-54 T 13-10-2018 TOPB45_1471 45beec2b30a8bc45fdfe2b2d6b252c6f 254 Pfam PF03309 Type III pantothenate kinase 2 206 2.8E-54 T 13-10-2018 IPR004619 Type III pantothenate kinase GO:0004594 KEGG: 00770+2.7.1.33|MetaCyc: PWY-3961 TOPB45_1471 45beec2b30a8bc45fdfe2b2d6b252c6f 254 TIGRFAM TIGR00671 baf: pantothenate kinase, type III 2 248 2.0E-53 T 13-10-2018 IPR004619 Type III pantothenate kinase GO:0004594 KEGG: 00770+2.7.1.33|MetaCyc: PWY-3961 TOPB45_1471 45beec2b30a8bc45fdfe2b2d6b252c6f 254 Gene3D G3DSA:3.30.420.40 1 89 7.6E-20 T 13-10-2018 TOPB45_1471 45beec2b30a8bc45fdfe2b2d6b252c6f 254 SUPERFAMILY SSF53067 1 121 1.75E-23 T 13-10-2018 TOPB45_1471 45beec2b30a8bc45fdfe2b2d6b252c6f 254 Hamap MF_01274 Type III pantothenate kinase [coaX]. 1 254 28.691 T 13-10-2018 IPR004619 Type III pantothenate kinase GO:0004594 KEGG: 00770+2.7.1.33|MetaCyc: PWY-3961 TOPB45_1004 3ca1817989e0ab5c1d49b339cc739c76 336 SUPERFAMILY SSF53955 86 238 1.36E-37 T 13-10-2018 IPR023346 Lysozyme-like domain superfamily TOPB45_1004 3ca1817989e0ab5c1d49b339cc739c76 336 ProSitePatterns PS00922 Prokaryotic transglycosylases signature. 106 134 - T 13-10-2018 IPR000189 Prokaryotic transglycosylase, active site GO:0000270|GO:0008933|GO:0016020 TOPB45_1004 3ca1817989e0ab5c1d49b339cc739c76 336 Gene3D G3DSA:1.10.530.10 84 231 1.3E-31 T 13-10-2018 TOPB45_1004 3ca1817989e0ab5c1d49b339cc739c76 336 Pfam PF01464 Transglycosylase SLT domain 97 197 1.9E-24 T 13-10-2018 IPR008258 Transglycosylase SLT domain 1 TOPB45_0660 da6264ff922a329238855265fc483177 323 Gene3D G3DSA:3.40.50.720 5 298 1.2E-100 T 13-10-2018 TOPB45_0660 da6264ff922a329238855265fc483177 323 Gene3D G3DSA:3.90.25.10 180 310 1.2E-100 T 13-10-2018 TOPB45_0660 da6264ff922a329238855265fc483177 323 PRINTS PR01713 Nucleotide sugar epimerase signature 216 231 2.3E-16 T 13-10-2018 TOPB45_0660 da6264ff922a329238855265fc483177 323 PRINTS PR01713 Nucleotide sugar epimerase signature 30 46 2.3E-16 T 13-10-2018 TOPB45_0660 da6264ff922a329238855265fc483177 323 PRINTS PR01713 Nucleotide sugar epimerase signature 277 294 2.3E-16 T 13-10-2018 TOPB45_0660 da6264ff922a329238855265fc483177 323 PRINTS PR01713 Nucleotide sugar epimerase signature 237 252 2.3E-16 T 13-10-2018 TOPB45_0660 da6264ff922a329238855265fc483177 323 Pfam PF16363 GDP-mannose 4,6 dehydratase 5 307 3.2E-58 T 13-10-2018 IPR016040 NAD(P)-binding domain TOPB45_0660 da6264ff922a329238855265fc483177 323 SUPERFAMILY SSF51735 2 316 1.81E-91 T 13-10-2018 IPR036291 NAD(P)-binding domain superfamily TOPB45_0097 ec09f394dba1b60730a3a38244767a15 409 TIGRFAM TIGR01962 NuoD: NADH dehydrogenase (quinone), D subunit 21 409 1.0E-151 T 13-10-2018 IPR022885 NAD(P)H-quinone oxidoreductase subunit D/H GO:0016651|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_0097 ec09f394dba1b60730a3a38244767a15 409 Hamap MF_01358 NAD(P)H-quinone oxidoreductase subunit H, chloroplastic [ndhH]. 12 409 46.579 T 13-10-2018 IPR022885 NAD(P)H-quinone oxidoreductase subunit D/H GO:0016651|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_0097 ec09f394dba1b60730a3a38244767a15 409 Gene3D G3DSA:1.10.645.20 19 409 4.0E-156 T 13-10-2018 IPR038290 NADH-quinone oxidoreductase, subunit D superfamily Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_0097 ec09f394dba1b60730a3a38244767a15 409 SUPERFAMILY SSF56762 30 409 2.35E-123 T 13-10-2018 IPR029014 [NiFe]-hydrogenase, large subunit Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_0097 ec09f394dba1b60730a3a38244767a15 409 Pfam PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 134 409 2.7E-107 T 13-10-2018 IPR001135 NADH-quinone oxidoreductase, subunit D GO:0016651|GO:0048038|GO:0051287|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_0603 47e2841e1beb1c37c5616533bf4958a2 542 Gene3D G3DSA:3.90.76.10 68 185 2.7E-155 T 13-10-2018 TOPB45_0603 47e2841e1beb1c37c5616533bf4958a2 542 ProSitePatterns PS01040 Bacterial extracellular solute-binding proteins, family 5 signature. 85 107 - T 13-10-2018 IPR023765 Solute-binding protein family 5, conserved site TOPB45_0603 47e2841e1beb1c37c5616533bf4958a2 542 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle 80 440 9.4E-92 T 13-10-2018 IPR000914 Solute-binding protein family 5 domain TOPB45_0603 47e2841e1beb1c37c5616533bf4958a2 542 Gene3D G3DSA:3.10.105.10 281 502 2.7E-155 T 13-10-2018 TOPB45_0603 47e2841e1beb1c37c5616533bf4958a2 542 PIRSF PIRSF002741 1 536 5.0E-154 T 13-10-2018 IPR030678 Peptide/nickel binding protein, MppA-type GO:0043190|GO:0055085 TOPB45_0603 47e2841e1beb1c37c5616533bf4958a2 542 SUPERFAMILY SSF53850 35 532 2.9E-142 T 13-10-2018 TOPB45_0603 47e2841e1beb1c37c5616533bf4958a2 542 Gene3D G3DSA:3.40.190.10 49 517 2.7E-155 T 13-10-2018 TOPB45_1388 b54f7afb11effa7659f0b39ea4d7aea1 292 Gene3D G3DSA:3.40.50.300 2 167 2.3E-7 T 13-10-2018 TOPB45_1388 b54f7afb11effa7659f0b39ea4d7aea1 292 Pfam PF03668 P-loop ATPase protein family 1 287 4.4E-89 T 13-10-2018 IPR005337 RapZ-like family GO:0005524 TOPB45_1388 b54f7afb11effa7659f0b39ea4d7aea1 292 SUPERFAMILY SSF52540 3 158 4.26E-14 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1388 b54f7afb11effa7659f0b39ea4d7aea1 292 PIRSF PIRSF005052 1 289 2.5E-100 T 13-10-2018 IPR005337 RapZ-like family GO:0005524 TOPB45_1388 b54f7afb11effa7659f0b39ea4d7aea1 292 Hamap MF_00636 RNase adapter protein RapZ [rapZ]. 1 287 39.127 T 13-10-2018 IPR005337 RapZ-like family GO:0005524 TOPB45_1220 994274efe94da6691bcab08acbe38bb0 243 Gene3D G3DSA:3.30.70.1890 1 117 1.4E-9 T 13-10-2018 TOPB45_1220 994274efe94da6691bcab08acbe38bb0 243 TIGRFAM TIGR01877 cas_cas6: CRISPR-associated endoribonuclease Cas6 39 238 4.2E-30 T 13-10-2018 IPR010156 CRISPR-associated protein, Cas6 GO:0016788 TOPB45_1220 994274efe94da6691bcab08acbe38bb0 243 Gene3D G3DSA:3.30.70.1900 119 241 1.1E-23 T 13-10-2018 TOPB45_1220 994274efe94da6691bcab08acbe38bb0 243 Pfam PF01881 CRISPR associated protein Cas6 92 238 3.8E-33 T 13-10-2018 IPR010156 CRISPR-associated protein, Cas6 GO:0016788 TOPB45_0134 6b937e70e58083915492b05bca9c2bbd 261 Gene3D G3DSA:3.40.50.300 14 254 1.0E-52 T 13-10-2018 TOPB45_0134 6b937e70e58083915492b05bca9c2bbd 261 ProSitePatterns PS01215 Mrp family signature. 131 147 - T 13-10-2018 IPR000808 Mrp, conserved site GO:0005524 TOPB45_0134 6b937e70e58083915492b05bca9c2bbd 261 SUPERFAMILY SSF52540 29 257 1.13E-40 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0134 6b937e70e58083915492b05bca9c2bbd 261 Pfam PF10609 NUBPL iron-transfer P-loop NTPase 26 252 1.1E-60 T 13-10-2018 IPR033756 Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35 TOPB45_0134 6b937e70e58083915492b05bca9c2bbd 261 Hamap MF_02040 Iron-sulfur cluster carrier protein. 21 254 30.569 T 13-10-2018 IPR019591 Mrp/NBP35 ATP-binding protein TOPB45_0364 dd685b833af0442ba92fee621ecef4c1 472 Gene3D G3DSA:2.40.160.130 29 460 1.8E-98 T 13-10-2018 IPR038636 Capsule assembly protein Wzi superfamily TOPB45_0364 dd685b833af0442ba92fee621ecef4c1 472 Pfam PF14052 Capsule assembly protein Wzi 118 450 1.3E-78 T 13-10-2018 IPR026950 Capsule assembly protein Wzi TOPB45_0235 5fda91f977c0f7946b1db4022e046cc3 310 SUPERFAMILY SSF51445 57 300 1.05E-43 T 13-10-2018 IPR017853 Glycoside hydrolase superfamily TOPB45_0235 5fda91f977c0f7946b1db4022e046cc3 310 Gene3D G3DSA:3.20.20.300 1 308 4.7E-66 T 13-10-2018 IPR036962 Glycoside hydrolase, family 3, N-terminal domain superfamily GO:0004553|GO:0005975 TOPB45_0235 5fda91f977c0f7946b1db4022e046cc3 310 Pfam PF00933 Glycosyl hydrolase family 3 N terminal domain 57 299 2.9E-42 T 13-10-2018 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 TOPB45_1168 385cf2dd48733b1d444f99595c80d464 623 SUPERFAMILY SSF54292 1 86 2.77E-16 T 13-10-2018 IPR036010 2Fe-2S ferredoxin-like superfamily GO:0009055|GO:0051536 TOPB45_1168 385cf2dd48733b1d444f99595c80d464 623 Gene3D G3DSA:3.30.420.480 195 366 1.2E-54 T 13-10-2018 TOPB45_1168 385cf2dd48733b1d444f99595c80d464 623 Pfam PF00111 2Fe-2S iron-sulfur cluster binding domain 12 71 3.3E-7 T 13-10-2018 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 TOPB45_1168 385cf2dd48733b1d444f99595c80d464 623 Gene3D G3DSA:2.40.50.570 109 193 7.9E-12 T 13-10-2018 TOPB45_1168 385cf2dd48733b1d444f99595c80d464 623 Gene3D G3DSA:3.10.20.30 1 85 1.5E-15 T 13-10-2018 IPR012675 Beta-grasp domain superfamily TOPB45_1168 385cf2dd48733b1d444f99595c80d464 623 Pfam PF14574 Domain of unknown function (DUF4445) 196 605 2.6E-142 T 13-10-2018 IPR027980 Protein of unknown function DUF4445 TOPB45_1110 4fc459c98e58f30a4e9ae7d438ffa6d3 139 Pfam PF03750 Csm2 Type III-A 39 135 6.3E-10 T 13-10-2018 IPR010149 CRISPR-associated protein, Csm2 Type III-A TOPB45_1110 4fc459c98e58f30a4e9ae7d438ffa6d3 139 TIGRFAM TIGR01870 cas_TM1810_Csm2: CRISPR type III-A/MTUBE-associated protein Csm2 48 135 3.7E-10 T 13-10-2018 IPR010149 CRISPR-associated protein, Csm2 Type III-A TOPB45_0539 c7ad5f360b12f9001d85eaf3cda532db 54 SUPERFAMILY SSF57802 3 52 3.03E-24 T 13-10-2018 TOPB45_0539 c7ad5f360b12f9001d85eaf3cda532db 54 PRINTS PR00163 Rubredoxin signature 3 19 3.0E-13 T 13-10-2018 IPR024935 Rubredoxin domain GO:0005506 TOPB45_0539 c7ad5f360b12f9001d85eaf3cda532db 54 PRINTS PR00163 Rubredoxin signature 33 49 3.0E-13 T 13-10-2018 IPR024935 Rubredoxin domain GO:0005506 TOPB45_0539 c7ad5f360b12f9001d85eaf3cda532db 54 ProSitePatterns PS00202 Rubredoxin signature. 33 43 - T 13-10-2018 IPR018527 Rubredoxin, iron-binding site GO:0046872 TOPB45_0539 c7ad5f360b12f9001d85eaf3cda532db 54 Pfam PF00301 Rubredoxin 3 49 3.8E-26 T 13-10-2018 IPR024935 Rubredoxin domain GO:0005506 TOPB45_0539 c7ad5f360b12f9001d85eaf3cda532db 54 PIRSF PIRSF000071 1 54 2.2E-30 T 13-10-2018 IPR024922 Rubredoxin GO:0005506|GO:0009055 TOPB45_0539 c7ad5f360b12f9001d85eaf3cda532db 54 Gene3D G3DSA:2.20.28.10 1 53 1.1E-29 T 13-10-2018 TOPB45_1624 469c9734c43cc15dc54602f4debf9d9b 191 Pfam PF05683 Fumarase C-terminus 22 186 7.1E-51 T 13-10-2018 IPR004647 Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain GO:0016836 TOPB45_1624 469c9734c43cc15dc54602f4debf9d9b 191 SUPERFAMILY SSF117457 23 185 9.29E-51 T 13-10-2018 IPR036660 Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain superfamily GO:0016836 TOPB45_1624 469c9734c43cc15dc54602f4debf9d9b 191 TIGRFAM TIGR00723 ttdB_fumA_fumB: hydrolyase, tartrate beta subunit/fumarate domain protein, Fe-S type 26 185 2.8E-45 T 13-10-2018 IPR004647 Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain GO:0016836 TOPB45_1624 469c9734c43cc15dc54602f4debf9d9b 191 Gene3D G3DSA:3.20.130.10 1 186 3.3E-57 T 13-10-2018 IPR036660 Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain superfamily GO:0016836 TOPB45_0629 1e455c535e518b0f9fd949d6c66f5a53 322 SMART SM00267 136 306 9.2E-48 T 13-10-2018 IPR000160 GGDEF domain TOPB45_0629 1e455c535e518b0f9fd949d6c66f5a53 322 Gene3D G3DSA:3.30.70.270 145 312 6.4E-50 T 13-10-2018 TOPB45_0629 1e455c535e518b0f9fd949d6c66f5a53 322 Gene3D G3DSA:3.40.50.2300 9 144 1.7E-11 T 13-10-2018 TOPB45_0629 1e455c535e518b0f9fd949d6c66f5a53 322 SUPERFAMILY SSF52172 32 162 2.13E-11 T 13-10-2018 IPR011006 CheY-like superfamily TOPB45_0629 1e455c535e518b0f9fd949d6c66f5a53 322 SUPERFAMILY SSF55073 152 305 1.41E-44 T 13-10-2018 IPR029787 Nucleotide cyclase TOPB45_0629 1e455c535e518b0f9fd949d6c66f5a53 322 Pfam PF00990 Diguanylate cyclase, GGDEF domain 150 301 4.3E-42 T 13-10-2018 IPR000160 GGDEF domain TOPB45_0629 1e455c535e518b0f9fd949d6c66f5a53 322 TIGRFAM TIGR00254 GGDEF: diguanylate cyclase (GGDEF) domain 144 305 1.2E-47 T 13-10-2018 IPR000160 GGDEF domain TOPB45_0629 1e455c535e518b0f9fd949d6c66f5a53 322 Pfam PF00072 Response regulator receiver domain 32 129 1.4E-4 T 13-10-2018 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TOPB45_1150 805ed5c00acc5a4be5d237725222b2f5 236 SUPERFAMILY SSF54211 1 179 2.78E-41 T 13-10-2018 IPR020568 Ribosomal protein S5 domain 2-type fold TOPB45_1150 805ed5c00acc5a4be5d237725222b2f5 236 Pfam PF01138 3' exoribonuclease family, domain 1 10 137 2.0E-21 T 13-10-2018 IPR001247 Exoribonuclease, phosphorolytic domain 1 Reactome: R-HSA-380994|Reactome: R-HSA-429958|Reactome: R-HSA-450385|Reactome: R-HSA-450513|Reactome: R-HSA-450604|Reactome: R-HSA-6791226 TOPB45_1150 805ed5c00acc5a4be5d237725222b2f5 236 Gene3D G3DSA:3.30.230.70 13 236 2.6E-54 T 13-10-2018 IPR027408 PNPase/RNase PH domain superfamily Reactome: R-HSA-380994|Reactome: R-HSA-429958|Reactome: R-HSA-450385|Reactome: R-HSA-450513|Reactome: R-HSA-450604|Reactome: R-HSA-6791226 TOPB45_1150 805ed5c00acc5a4be5d237725222b2f5 236 SUPERFAMILY SSF55666 151 236 2.23E-21 T 13-10-2018 IPR036345 Exoribonuclease, PH domain 2 superfamily Reactome: R-HSA-380994|Reactome: R-HSA-429958|Reactome: R-HSA-450385|Reactome: R-HSA-450513|Reactome: R-HSA-450604|Reactome: R-HSA-6791226 TOPB45_1150 805ed5c00acc5a4be5d237725222b2f5 236 Hamap MF_00564 Ribonuclease PH [rph]. 11 235 38.971 T 13-10-2018 IPR002381 Ribonuclease PH, bacterial-type GO:0000049|GO:0008033|GO:0009022 TOPB45_1150 805ed5c00acc5a4be5d237725222b2f5 236 Pfam PF03725 3' exoribonuclease family, domain 2 157 221 1.7E-9 T 13-10-2018 IPR015847 Exoribonuclease, phosphorolytic domain 2 Reactome: R-HSA-380994|Reactome: R-HSA-429958|Reactome: R-HSA-450385|Reactome: R-HSA-450513|Reactome: R-HSA-450604|Reactome: R-HSA-6791226 TOPB45_1150 805ed5c00acc5a4be5d237725222b2f5 236 TIGRFAM TIGR01966 RNasePH: ribonuclease PH 2 234 7.8E-95 T 13-10-2018 IPR002381 Ribonuclease PH, bacterial-type GO:0000049|GO:0008033|GO:0009022 TOPB45_1074 2d595c024a1d7a87e84f1940b47a1952 298 Pfam PF03706 Lysylphosphatidylglycerol synthase TM region 11 282 1.8E-32 T 13-10-2018 IPR022791 Lysylphosphatidylglycerol synthetase/glycosyltransferase AglD TOPB45_1573 ba432a2d8e018ea6db50a44aa4683f49 878 Gene3D G3DSA:3.10.20.310 212 289 1.9E-16 T 13-10-2018 TOPB45_1573 ba432a2d8e018ea6db50a44aa4683f49 878 Gene3D G3DSA:3.10.20.310 477 550 3.7E-24 T 13-10-2018 TOPB45_1573 ba432a2d8e018ea6db50a44aa4683f49 878 Gene3D G3DSA:2.40.160.50 552 878 8.5E-98 T 13-10-2018 TOPB45_1573 ba432a2d8e018ea6db50a44aa4683f49 878 Pfam PF01103 Surface antigen 577 878 3.6E-75 T 13-10-2018 IPR000184 Bacterial surface antigen (D15) GO:0019867 Reactome: R-HSA-1268020|Reactome: R-HSA-8949613 TOPB45_1573 ba432a2d8e018ea6db50a44aa4683f49 878 PIRSF PIRSF006076 96 878 2.8E-223 T 13-10-2018 IPR023707 Outer membrane protein assembly factor BamA GO:0071709 TOPB45_1573 ba432a2d8e018ea6db50a44aa4683f49 878 TIGRFAM TIGR03303 OM_YaeT: outer membrane protein assembly complex, YaeT protein 140 878 3.6E-208 T 13-10-2018 IPR023707 Outer membrane protein assembly factor BamA GO:0071709 TOPB45_1573 ba432a2d8e018ea6db50a44aa4683f49 878 Gene3D G3DSA:3.10.20.310 137 210 1.1E-19 T 13-10-2018 TOPB45_1573 ba432a2d8e018ea6db50a44aa4683f49 878 Gene3D G3DSA:3.10.20.310 292 395 2.5E-18 T 13-10-2018 TOPB45_1573 ba432a2d8e018ea6db50a44aa4683f49 878 Pfam PF07244 Surface antigen variable number repeat 397 474 7.0E-11 T 13-10-2018 IPR010827 POTRA domain, BamA/TamA-like GO:0019867 TOPB45_1573 ba432a2d8e018ea6db50a44aa4683f49 878 Pfam PF07244 Surface antigen variable number repeat 293 394 9.0E-11 T 13-10-2018 IPR010827 POTRA domain, BamA/TamA-like GO:0019867 TOPB45_1573 ba432a2d8e018ea6db50a44aa4683f49 878 Pfam PF07244 Surface antigen variable number repeat 213 289 1.8E-16 T 13-10-2018 IPR010827 POTRA domain, BamA/TamA-like GO:0019867 TOPB45_1573 ba432a2d8e018ea6db50a44aa4683f49 878 Pfam PF07244 Surface antigen variable number repeat 142 210 1.2E-12 T 13-10-2018 IPR010827 POTRA domain, BamA/TamA-like GO:0019867 TOPB45_1573 ba432a2d8e018ea6db50a44aa4683f49 878 Pfam PF07244 Surface antigen variable number repeat 477 549 1.4E-15 T 13-10-2018 IPR010827 POTRA domain, BamA/TamA-like GO:0019867 TOPB45_1573 ba432a2d8e018ea6db50a44aa4683f49 878 Hamap MF_01430 Outer membrane protein assembly factor BamA [bamA]. 132 878 21.366 T 13-10-2018 IPR023707 Outer membrane protein assembly factor BamA GO:0071709 TOPB45_1573 ba432a2d8e018ea6db50a44aa4683f49 878 Gene3D G3DSA:3.10.20.310 396 475 8.0E-14 T 13-10-2018 TOPB45_1465 3e4b3dff399a2187ba23431a8444402a 367 Pfam PF02636 Putative S-adenosyl-L-methionine-dependent methyltransferase 56 288 4.4E-48 T 13-10-2018 IPR003788 Protein arginine methyltransferase NDUFAF7 Reactome: R-HSA-6799198 TOPB45_1465 3e4b3dff399a2187ba23431a8444402a 367 Gene3D G3DSA:3.40.50.12710 2 364 9.9E-94 T 13-10-2018 IPR038375 Protein arginine methyltransferase NDUFAF7 superfamily Reactome: R-HSA-6799198 TOPB45_1465 3e4b3dff399a2187ba23431a8444402a 367 SUPERFAMILY SSF53335 3 342 4.32E-91 T 13-10-2018 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TOPB45_0163 b5ed3f7df872456c562524a146e48b26 1353 Pfam PF00623 RNA polymerase Rpb1, domain 2 344 380 2.9E-7 T 13-10-2018 IPR000722 RNA polymerase, alpha subunit GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TOPB45_0163 b5ed3f7df872456c562524a146e48b26 1353 Pfam PF00623 RNA polymerase Rpb1, domain 2 391 484 9.0E-25 T 13-10-2018 IPR000722 RNA polymerase, alpha subunit GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TOPB45_0163 b5ed3f7df872456c562524a146e48b26 1353 Pfam PF05000 RNA polymerase Rpb1, domain 4 660 750 1.1E-17 T 13-10-2018 IPR007083 RNA polymerase Rpb1, domain 4 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TOPB45_0163 b5ed3f7df872456c562524a146e48b26 1353 TIGRFAM TIGR02386 rpoC_TIGR: DNA-directed RNA polymerase, beta' subunit 19 1348 0.0 T 13-10-2018 IPR012754 DNA-directed RNA polymerase, subunit beta-prime GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TOPB45_0163 b5ed3f7df872456c562524a146e48b26 1353 Gene3D G3DSA:1.10.274.100 553 627 4.8E-19 T 13-10-2018 TOPB45_0163 b5ed3f7df872456c562524a146e48b26 1353 Gene3D G3DSA:1.10.150.390 1297 1352 7.3E-28 T 13-10-2018 TOPB45_0163 b5ed3f7df872456c562524a146e48b26 1353 SUPERFAMILY SSF64484 16 1344 0.0 T 13-10-2018 TOPB45_0163 b5ed3f7df872456c562524a146e48b26 1353 Gene3D G3DSA:1.10.40.90 374 416 5.8E-20 T 13-10-2018 TOPB45_0163 b5ed3f7df872456c562524a146e48b26 1353 Gene3D G3DSA:2.40.50.100 935 1009 2.8E-22 T 13-10-2018 TOPB45_0163 b5ed3f7df872456c562524a146e48b26 1353 Pfam PF04998 RNA polymerase Rpb1, domain 5 753 1293 7.4E-72 T 13-10-2018 IPR007081 RNA polymerase Rpb1, domain 5 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TOPB45_0163 b5ed3f7df872456c562524a146e48b26 1353 Pfam PF04997 RNA polymerase Rpb1, domain 1 16 342 2.3E-88 T 13-10-2018 IPR007080 RNA polymerase Rpb1, domain 1 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TOPB45_0163 b5ed3f7df872456c562524a146e48b26 1353 Pfam PF04983 RNA polymerase Rpb1, domain 3 489 629 6.0E-25 T 13-10-2018 IPR007066 RNA polymerase Rpb1, domain 3 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TOPB45_0163 b5ed3f7df872456c562524a146e48b26 1353 Hamap MF_01322 DNA-directed RNA polymerase subunit beta' [rpoC]. 10 1350 18.736 T 13-10-2018 IPR012754 DNA-directed RNA polymerase, subunit beta-prime GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TOPB45_0163 b5ed3f7df872456c562524a146e48b26 1353 Gene3D G3DSA:1.10.274.100 490 552 6.7E-24 T 13-10-2018 TOPB45_0163 b5ed3f7df872456c562524a146e48b26 1353 Gene3D G3DSA:2.40.50.100 1010 1108 4.8E-29 T 13-10-2018 TOPB45_0163 b5ed3f7df872456c562524a146e48b26 1353 Gene3D G3DSA:2.40.50.100 1133 1196 1.1E-67 T 13-10-2018 TOPB45_0163 b5ed3f7df872456c562524a146e48b26 1353 SMART SM00663 235 514 8.3E-163 T 13-10-2018 IPR006592 RNA polymerase, N-terminal GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TOPB45_0163 b5ed3f7df872456c562524a146e48b26 1353 Gene3D G3DSA:1.10.1790.20 1117 1295 1.1E-67 T 13-10-2018 TOPB45_0163 b5ed3f7df872456c562524a146e48b26 1353 Gene3D G3DSA:1.10.132.30 628 777 2.6E-64 T 13-10-2018 IPR038120 RNA polymerase Rpb1, funnel domain superfamily KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 TOPB45_0600 9d9d3dd4cd8e28b04bad04c5d0b240b7 707 Pfam PF06202 Amylo-alpha-1,6-glucosidase 270 636 8.6E-17 T 13-10-2018 IPR032790 Glycogen debranching enzyme, C-terminal KEGG: 00500+2.4.1.25|MetaCyc: PWY-5941|MetaCyc: PWY-6724|MetaCyc: PWY-6737|MetaCyc: PWY-7238|Reactome: R-HSA-6798695|Reactome: R-HSA-70221 TOPB45_0600 9d9d3dd4cd8e28b04bad04c5d0b240b7 707 SUPERFAMILY SSF48208 224 689 3.33E-92 T 13-10-2018 IPR008928 Six-hairpin glycosidase superfamily GO:0003824 TOPB45_0600 9d9d3dd4cd8e28b04bad04c5d0b240b7 707 Pfam PF14742 N-terminal domain of (some) glycogen debranching enzymes 16 209 1.1E-50 T 13-10-2018 IPR032856 Putative glycogen debranching enzyme, N-terminal TOPB45_0600 9d9d3dd4cd8e28b04bad04c5d0b240b7 707 Gene3D G3DSA:1.50.10.10 250 643 5.9E-61 T 13-10-2018 IPR012341 Six-hairpin glycosidase-like superfamily GO:0003824 TOPB45_0303 dcf6b3c0250fd96db4c4fcc43b606dc2 90 PRINTS PR00112 Acylphosphatase signature 3 18 6.4E-8 T 13-10-2018 IPR020456 Acylphosphatase GO:0003998 KEGG: 00620+3.6.1.7|KEGG: 00627+3.6.1.7 TOPB45_0303 dcf6b3c0250fd96db4c4fcc43b606dc2 90 PRINTS PR00112 Acylphosphatase signature 24 49 6.4E-8 T 13-10-2018 IPR020456 Acylphosphatase GO:0003998 KEGG: 00620+3.6.1.7|KEGG: 00627+3.6.1.7 TOPB45_0303 dcf6b3c0250fd96db4c4fcc43b606dc2 90 Gene3D G3DSA:3.30.70.100 1 89 1.5E-35 T 13-10-2018 TOPB45_0303 dcf6b3c0250fd96db4c4fcc43b606dc2 90 ProSitePatterns PS00150 Acylphosphatase signature 1. 8 18 - T 13-10-2018 IPR017968 Acylphosphatase, conserved site KEGG: 00620+3.6.1.7|KEGG: 00627+3.6.1.7 TOPB45_0303 dcf6b3c0250fd96db4c4fcc43b606dc2 90 Pfam PF00708 Acylphosphatase 4 88 7.3E-29 T 13-10-2018 IPR001792 Acylphosphatase-like domain KEGG: 00620+3.6.1.7|KEGG: 00627+3.6.1.7 TOPB45_0303 dcf6b3c0250fd96db4c4fcc43b606dc2 90 SUPERFAMILY SSF54975 1 90 6.11E-32 T 13-10-2018 IPR036046 Acylphosphatase-like domain superfamily KEGG: 00620+3.6.1.7|KEGG: 00627+3.6.1.7 TOPB45_0303 dcf6b3c0250fd96db4c4fcc43b606dc2 90 ProSitePatterns PS00151 Acylphosphatase signature 2. 32 48 - T 13-10-2018 IPR017968 Acylphosphatase, conserved site KEGG: 00620+3.6.1.7|KEGG: 00627+3.6.1.7 TOPB45_0220 a088a2d491a48278af410c5ace840b88 293 Pfam PF08340 Domain of unknown function (DUF1732) 210 292 8.1E-30 T 13-10-2018 IPR013551 Domain of unknown function DUF1732 TOPB45_0220 a088a2d491a48278af410c5ace840b88 293 Pfam PF03755 YicC-like family, N-terminal region 1 155 1.8E-38 T 13-10-2018 IPR013527 YicC-like, N-terminal TOPB45_0220 a088a2d491a48278af410c5ace840b88 293 TIGRFAM TIGR00255 TIGR00255: TIGR00255 family protein 2 292 1.8E-64 T 13-10-2018 IPR005229 Conserved hypothetical protein CHP00255 TOPB45_0468 d4454161721818af833d4fede4740305 322 Pfam PF01925 Sulfite exporter TauE/SafE 51 312 3.6E-36 T 13-10-2018 IPR002781 Transmembrane protein TauE-like GO:0016021 TOPB45_0506 85699a34a4f6772eddfa1deab55450db 370 PIRSF PIRSF004762 17 369 5.9E-107 T 13-10-2018 TOPB45_0506 85699a34a4f6772eddfa1deab55450db 370 Pfam PF13353 4Fe-4S single cluster domain 81 185 1.3E-4 T 13-10-2018 TOPB45_0506 85699a34a4f6772eddfa1deab55450db 370 SMART SM00729 78 296 1.7E-5 T 13-10-2018 IPR006638 Elp3/MiaB/NifB GO:0003824|GO:0051536 TOPB45_0506 85699a34a4f6772eddfa1deab55450db 370 SUPERFAMILY SSF102114 40 364 4.32E-50 T 13-10-2018 TOPB45_0506 85699a34a4f6772eddfa1deab55450db 370 TIGRFAM TIGR00423 TIGR00423: radical SAM domain protein, CofH subfamily 75 365 4.2E-106 T 13-10-2018 IPR020050 FO synthase, subunit 2 GO:0016765 KEGG: 00680+2.5.1.77 TOPB45_0506 85699a34a4f6772eddfa1deab55450db 370 Gene3D G3DSA:3.20.20.70 15 367 1.8E-55 T 13-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 TOPB45_0506 85699a34a4f6772eddfa1deab55450db 370 Pfam PF04055 Radical SAM superfamily 82 251 2.6E-16 T 13-10-2018 IPR007197 Radical SAM GO:0003824|GO:0051536 TOPB45_1064 80904e6c6ec9145489929a3a3115e150 342 Gene3D G3DSA:1.20.58.1130 7 229 8.9E-34 T 13-10-2018 TOPB45_1064 80904e6c6ec9145489929a3a3115e150 342 Pfam PF01699 Sodium/calcium exchanger protein 3 161 5.0E-16 T 13-10-2018 IPR004837 Sodium/calcium exchanger membrane region GO:0016021|GO:0055085 Reactome: R-HSA-425561 TOPB45_1064 80904e6c6ec9145489929a3a3115e150 342 Pfam PF01699 Sodium/calcium exchanger protein 197 337 5.5E-12 T 13-10-2018 IPR004837 Sodium/calcium exchanger membrane region GO:0016021|GO:0055085 Reactome: R-HSA-425561 TOPB45_1064 80904e6c6ec9145489929a3a3115e150 342 Gene3D G3DSA:1.20.1420.30 33 312 8.9E-34 T 13-10-2018 TOPB45_0908 74f620004295f3d5f53f8e2654fd58ce 207 Pfam PF00196 Bacterial regulatory proteins, luxR family 131 185 4.6E-20 T 13-10-2018 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TOPB45_0908 74f620004295f3d5f53f8e2654fd58ce 207 Gene3D G3DSA:3.40.50.2300 6 124 6.3E-7 T 13-10-2018 TOPB45_0908 74f620004295f3d5f53f8e2654fd58ce 207 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 132 146 4.6E-14 T 13-10-2018 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TOPB45_0908 74f620004295f3d5f53f8e2654fd58ce 207 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 162 174 4.6E-14 T 13-10-2018 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TOPB45_0908 74f620004295f3d5f53f8e2654fd58ce 207 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 146 162 4.6E-14 T 13-10-2018 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TOPB45_0908 74f620004295f3d5f53f8e2654fd58ce 207 SUPERFAMILY SSF46894 123 188 1.6E-20 T 13-10-2018 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 TOPB45_0908 74f620004295f3d5f53f8e2654fd58ce 207 SMART SM00421 129 186 2.0E-21 T 13-10-2018 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 TOPB45_0908 74f620004295f3d5f53f8e2654fd58ce 207 Gene3D G3DSA:1.10.10.10 131 190 3.9E-22 T 13-10-2018 IPR036388 Winged helix-like DNA-binding domain superfamily TOPB45_1301 24085700b74a7445f1615c0bfdd691ed 483 Pfam PF13372 Alginate export 236 469 8.7E-16 T 13-10-2018 IPR025388 Alginate export domain TOPB45_1617 4f6ae89d2f09733ace59872ce4528899 300 Gene3D G3DSA:3.50.50.60 115 224 7.2E-77 T 13-10-2018 IPR036188 FAD/NAD(P)-binding domain superfamily TOPB45_1617 4f6ae89d2f09733ace59872ce4528899 300 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 218 234 5.6E-20 T 13-10-2018 TOPB45_1617 4f6ae89d2f09733ace59872ce4528899 300 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 5 24 5.6E-20 T 13-10-2018 TOPB45_1617 4f6ae89d2f09733ace59872ce4528899 300 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 247 269 5.6E-20 T 13-10-2018 TOPB45_1617 4f6ae89d2f09733ace59872ce4528899 300 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 143 161 5.6E-20 T 13-10-2018 TOPB45_1617 4f6ae89d2f09733ace59872ce4528899 300 SUPERFAMILY SSF51905 1 295 8.3E-37 T 13-10-2018 IPR036188 FAD/NAD(P)-binding domain superfamily TOPB45_1617 4f6ae89d2f09733ace59872ce4528899 300 Gene3D G3DSA:3.50.50.60 3 287 7.2E-77 T 13-10-2018 IPR036188 FAD/NAD(P)-binding domain superfamily TOPB45_1617 4f6ae89d2f09733ace59872ce4528899 300 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 4 26 9.5E-32 T 13-10-2018 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TOPB45_1617 4f6ae89d2f09733ace59872ce4528899 300 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 257 275 9.5E-32 T 13-10-2018 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TOPB45_1617 4f6ae89d2f09733ace59872ce4528899 300 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 56 66 9.5E-32 T 13-10-2018 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TOPB45_1617 4f6ae89d2f09733ace59872ce4528899 300 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 35 50 9.5E-32 T 13-10-2018 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TOPB45_1617 4f6ae89d2f09733ace59872ce4528899 300 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 139 163 9.5E-32 T 13-10-2018 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TOPB45_1617 4f6ae89d2f09733ace59872ce4528899 300 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 102 110 9.5E-32 T 13-10-2018 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TOPB45_1617 4f6ae89d2f09733ace59872ce4528899 300 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 124 136 9.5E-32 T 13-10-2018 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TOPB45_1617 4f6ae89d2f09733ace59872ce4528899 300 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 3 282 4.8E-35 T 13-10-2018 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TOPB45_0157 dfccf69f0626b795c1d6df2ecd4e9b86 380 SUPERFAMILY SSF53597 155 366 2.09E-58 T 13-10-2018 IPR024072 Dihydrofolate reductase-like domain superfamily Reactome: R-HSA-196757 TOPB45_0157 dfccf69f0626b795c1d6df2ecd4e9b86 380 Gene3D G3DSA:3.40.430.10 150 369 1.7E-71 T 13-10-2018 IPR024072 Dihydrofolate reductase-like domain superfamily Reactome: R-HSA-196757 TOPB45_0157 dfccf69f0626b795c1d6df2ecd4e9b86 380 Gene3D G3DSA:3.40.140.10 3 149 2.2E-43 T 13-10-2018 TOPB45_0157 dfccf69f0626b795c1d6df2ecd4e9b86 380 ProSitePatterns PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 59 97 - T 13-10-2018 IPR016192 APOBEC/CMP deaminase, zinc-binding GO:0008270|GO:0016787 TOPB45_0157 dfccf69f0626b795c1d6df2ecd4e9b86 380 PIRSF PIRSF006769 5 371 6.1E-126 T 13-10-2018 IPR004794 Riboflavin biosynthesis protein RibD GO:0008835|GO:0009231|GO:0055114 KEGG: 00740+3.5.4.26+1.1.1.193|MetaCyc: PWY-7991 TOPB45_0157 dfccf69f0626b795c1d6df2ecd4e9b86 380 SUPERFAMILY SSF53927 10 149 1.41E-42 T 13-10-2018 IPR016193 Cytidine deaminase-like GO:0003824 TOPB45_0157 dfccf69f0626b795c1d6df2ecd4e9b86 380 TIGRFAM TIGR00326 eubact_ribD: riboflavin biosynthesis protein RibD 14 364 8.8E-110 T 13-10-2018 IPR004794 Riboflavin biosynthesis protein RibD GO:0008835|GO:0009231|GO:0055114 KEGG: 00740+3.5.4.26+1.1.1.193|MetaCyc: PWY-7991 TOPB45_0157 dfccf69f0626b795c1d6df2ecd4e9b86 380 Pfam PF01872 RibD C-terminal domain 155 360 1.0E-48 T 13-10-2018 IPR002734 Bacterial bifunctional deaminase-reductase, C-terminal GO:0008703|GO:0009231|GO:0055114 TOPB45_0157 dfccf69f0626b795c1d6df2ecd4e9b86 380 TIGRFAM TIGR00227 ribD_Cterm: riboflavin-specific deaminase C-terminal domain 154 366 5.2E-59 T 13-10-2018 IPR011549 Riboflavin-specific deaminase, C-terminal GO:0008703|GO:0009231|GO:0050661|GO:0055114 TOPB45_0157 dfccf69f0626b795c1d6df2ecd4e9b86 380 Pfam PF00383 Cytidine and deoxycytidylate deaminase zinc-binding region 10 108 1.0E-20 T 13-10-2018 IPR002125 Cytidine and deoxycytidylate deaminase domain TOPB45_1474 231b284038f5d3fa8c534092eb60c435 78 Gene3D G3DSA:2.20.28.10 4 46 3.6E-6 T 13-10-2018 TOPB45_1474 231b284038f5d3fa8c534092eb60c435 78 SMART SM00834 1 41 3.9E-20 T 13-10-2018 IPR013429 Putative regulatory protein, FmdB, Zinc ribbon domain TOPB45_1474 231b284038f5d3fa8c534092eb60c435 78 Pfam PF09723 Zinc ribbon domain 1 40 5.4E-18 T 13-10-2018 IPR013429 Putative regulatory protein, FmdB, Zinc ribbon domain TOPB45_1474 231b284038f5d3fa8c534092eb60c435 78 TIGRFAM TIGR02605 CxxC_CxxC_SSSS: putative regulatory protein, FmdB family 1 51 2.0E-21 T 13-10-2018 IPR013429 Putative regulatory protein, FmdB, Zinc ribbon domain TOPB45_0952 a2e442b85120a6b58617ff15c3c8bb6c 182 Gene3D G3DSA:3.40.109.10 3 171 1.5E-6 T 13-10-2018 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 TOPB45_0952 a2e442b85120a6b58617ff15c3c8bb6c 182 Pfam PF09918 Uncharacterized protein containing a ferredoxin domain (DUF2148) 115 180 1.7E-32 T 13-10-2018 IPR019224 Protein of unknown function DUF2148 TOPB45_0710 d627b4c53761e4a294b6d49df93a12fc 69 Pfam PF00403 Heavy-metal-associated domain 7 65 7.6E-12 T 13-10-2018 IPR006121 Heavy metal-associated domain, HMA GO:0030001|GO:0046872 TOPB45_0710 d627b4c53761e4a294b6d49df93a12fc 69 PRINTS PR00944 Copper ion binding protein signature 4 16 2.1E-7 T 13-10-2018 IPR000428 Copper ion binding protein GO:0005507|GO:0006825 TOPB45_0710 d627b4c53761e4a294b6d49df93a12fc 69 PRINTS PR00944 Copper ion binding protein signature 54 67 2.1E-7 T 13-10-2018 IPR000428 Copper ion binding protein GO:0005507|GO:0006825 TOPB45_0710 d627b4c53761e4a294b6d49df93a12fc 69 PRINTS PR00944 Copper ion binding protein signature 16 29 2.1E-7 T 13-10-2018 IPR000428 Copper ion binding protein GO:0005507|GO:0006825 TOPB45_0710 d627b4c53761e4a294b6d49df93a12fc 69 PRINTS PR00944 Copper ion binding protein signature 29 42 2.1E-7 T 13-10-2018 IPR000428 Copper ion binding protein GO:0005507|GO:0006825 TOPB45_0710 d627b4c53761e4a294b6d49df93a12fc 69 ProSitePatterns PS01047 Heavy-metal-associated domain. 9 38 - T 13-10-2018 IPR017969 Heavy-metal-associated, conserved site GO:0030001|GO:0046872 TOPB45_0710 d627b4c53761e4a294b6d49df93a12fc 69 SUPERFAMILY SSF55008 2 67 9.03E-17 T 13-10-2018 IPR036163 Heavy metal-associated domain superfamily GO:0030001|GO:0046872 TOPB45_0710 d627b4c53761e4a294b6d49df93a12fc 69 Gene3D G3DSA:3.30.70.100 2 69 5.9E-17 T 13-10-2018 TOPB45_1431 8d64f5adb8025c715df7084ed9392358 193 Hamap MF_01078 UPF0278 protein . 3 193 27.779 T 13-10-2018 IPR014856 PIN-domain ribonuclease TOPB45_1431 8d64f5adb8025c715df7084ed9392358 193 Pfam PF08745 PINc domain ribonuclease 5 189 1.1E-56 T 13-10-2018 IPR014856 PIN-domain ribonuclease TOPB45_1431 8d64f5adb8025c715df7084ed9392358 193 TIGRFAM TIGR03875 RNA_lig_partner: RNA ligase partner, MJ_0950 family 5 190 5.1E-56 T 13-10-2018 IPR014856 PIN-domain ribonuclease TOPB45_0822 f2482d100c4907a6bc8248f848f3cef5 195 Hamap MF_00067 Phosphoheptose isomerase [gmhA]. 5 192 35.167 T 13-10-2018 IPR004515 Phosphoheptose isomerase GO:0005737|GO:0008968 KEGG: 00540+5.3.1.28|MetaCyc: PWY-6478 TOPB45_0822 f2482d100c4907a6bc8248f848f3cef5 195 Pfam PF13580 SIS domain 16 149 2.9E-29 T 13-10-2018 IPR001347 Sugar isomerase (SIS) GO:0097367|GO:1901135 TOPB45_0822 f2482d100c4907a6bc8248f848f3cef5 195 SUPERFAMILY SSF53697 7 191 1.22E-50 T 13-10-2018 TOPB45_0822 f2482d100c4907a6bc8248f848f3cef5 195 Gene3D G3DSA:3.40.50.10490 2 195 2.3E-68 T 13-10-2018 TOPB45_1340 202539c51026c4f2e475b221fd58a36d 273 Gene3D G3DSA:3.90.226.10 57 247 2.5E-22 T 13-10-2018 TOPB45_1340 202539c51026c4f2e475b221fd58a36d 273 SUPERFAMILY SSF52096 53 234 4.07E-27 T 13-10-2018 IPR029045 ClpP/crotonase-like domain superfamily TOPB45_1340 202539c51026c4f2e475b221fd58a36d 273 Pfam PF01972 Serine dehydrogenase proteinase 6 270 3.7E-115 T 13-10-2018 IPR002825 Peptidase S49, serine-peptidase prokaryotes GO:0016021 TOPB45_0507 d953356cf0720d778ea13473c13e3833 298 SUPERFAMILY SSF53448 5 214 5.3E-37 T 13-10-2018 IPR029044 Nucleotide-diphospho-sugar transferases TOPB45_0507 d953356cf0720d778ea13473c13e3833 298 Gene3D G3DSA:3.90.550.10 1 247 1.7E-38 T 13-10-2018 IPR029044 Nucleotide-diphospho-sugar transferases TOPB45_0507 d953356cf0720d778ea13473c13e3833 298 Pfam PF00535 Glycosyl transferase family 2 7 132 2.6E-28 T 13-10-2018 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 TOPB45_1084 5152ff20266b1b63e430aa14fe4b7e95 197 SUPERFAMILY SSF52317 27 195 4.58E-41 T 13-10-2018 IPR029062 Class I glutamine amidotransferase-like TOPB45_1084 5152ff20266b1b63e430aa14fe4b7e95 197 Gene3D G3DSA:3.40.50.880 22 196 2.4E-51 T 13-10-2018 IPR029062 Class I glutamine amidotransferase-like TOPB45_1084 5152ff20266b1b63e430aa14fe4b7e95 197 Pfam PF01965 DJ-1/PfpI family 28 191 1.6E-41 T 13-10-2018 IPR002818 DJ-1/PfpI Reactome: R-HSA-3899300 TOPB45_0072 df3092126487b40e0cab76b8237988a8 122 TIGRFAM TIGR02605 CxxC_CxxC_SSSS: putative regulatory protein, FmdB family 1 45 1.0E-13 T 13-10-2018 IPR013429 Putative regulatory protein, FmdB, Zinc ribbon domain TOPB45_0072 df3092126487b40e0cab76b8237988a8 122 SMART SM00834 1 41 6.4E-10 T 13-10-2018 IPR013429 Putative regulatory protein, FmdB, Zinc ribbon domain TOPB45_0072 df3092126487b40e0cab76b8237988a8 122 Pfam PF09723 Zinc ribbon domain 1 34 7.9E-13 T 13-10-2018 IPR013429 Putative regulatory protein, FmdB, Zinc ribbon domain TOPB45_0373 29c5d04466ceabe8b362b898042cee44 243 SMART SM00563 66 181 1.2E-40 T 13-10-2018 IPR002123 Phospholipid/glycerol acyltransferase GO:0016746 TOPB45_0373 29c5d04466ceabe8b362b898042cee44 243 Pfam PF01553 Acyltransferase 53 178 2.2E-27 T 13-10-2018 IPR002123 Phospholipid/glycerol acyltransferase GO:0016746 TOPB45_0373 29c5d04466ceabe8b362b898042cee44 243 SUPERFAMILY SSF69593 11 239 1.05E-50 T 13-10-2018 TOPB45_0373 29c5d04466ceabe8b362b898042cee44 243 TIGRFAM TIGR00530 AGP_acyltrn: 1-acylglycerol-3-phosphate O-acyltransferases 50 178 4.1E-34 T 13-10-2018 IPR004552 1-acyl-sn-glycerol-3-phosphate acyltransferase GO:0003841|GO:0008654|GO:0016020 KEGG: 00561+2.3.1.51|KEGG: 00564+2.3.1.51|MetaCyc: PWY-5667|MetaCyc: PWY-5981|MetaCyc: PWY-6453|MetaCyc: PWY-7411|MetaCyc: PWY-7417|MetaCyc: PWY-7587|MetaCyc: PWY-7589|MetaCyc: PWY-7782|Reactome: R-HSA-1483166 TOPB45_1575 f1bb9302137aef021edae67bc00af0a0 409 Pfam PF02687 FtsX-like permease family 304 399 9.8E-11 T 13-10-2018 IPR003838 ABC transporter permease protein domain GO:0016020 TOPB45_1575 f1bb9302137aef021edae67bc00af0a0 409 Pfam PF12704 MacB-like periplasmic core domain 30 242 3.3E-12 T 13-10-2018 IPR025857 MacB-like periplasmic core domain TOPB45_1242 840e8effbdd1fc9b4a057aade28ca7b8 283 SUPERFAMILY SSF52402 148 283 1.19E-32 T 13-10-2018 TOPB45_1242 840e8effbdd1fc9b4a057aade28ca7b8 283 PRINTS PR01438 Universal stress protein signature 243 255 1.1E-17 T 13-10-2018 IPR006015 Universal stress protein A TOPB45_1242 840e8effbdd1fc9b4a057aade28ca7b8 283 PRINTS PR01438 Universal stress protein signature 148 166 1.1E-17 T 13-10-2018 IPR006015 Universal stress protein A TOPB45_1242 840e8effbdd1fc9b4a057aade28ca7b8 283 PRINTS PR01438 Universal stress protein signature 261 283 1.1E-17 T 13-10-2018 IPR006015 Universal stress protein A TOPB45_1242 840e8effbdd1fc9b4a057aade28ca7b8 283 Gene3D G3DSA:3.40.50.620 2 141 3.0E-25 T 13-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TOPB45_1242 840e8effbdd1fc9b4a057aade28ca7b8 283 Gene3D G3DSA:3.40.50.620 145 283 9.3E-34 T 13-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TOPB45_1242 840e8effbdd1fc9b4a057aade28ca7b8 283 Pfam PF00582 Universal stress protein family 148 283 7.6E-29 T 13-10-2018 IPR006016 UspA TOPB45_1242 840e8effbdd1fc9b4a057aade28ca7b8 283 Pfam PF00582 Universal stress protein family 4 141 1.4E-21 T 13-10-2018 IPR006016 UspA TOPB45_1242 840e8effbdd1fc9b4a057aade28ca7b8 283 SUPERFAMILY SSF52402 4 143 3.85E-25 T 13-10-2018 TOPB45_1405 f84338b55d826572e4336c4770587ec2 87 SUPERFAMILY SSF46785 4 74 4.76E-18 T 13-10-2018 IPR036390 Winged helix DNA-binding domain superfamily TOPB45_1405 f84338b55d826572e4336c4770587ec2 87 Pfam PF08679 Dissimilatory sulfite reductase D (DsrD) 6 71 9.9E-28 T 13-10-2018 IPR014793 Dissimilatory sulphite reductase D TOPB45_1405 f84338b55d826572e4336c4770587ec2 87 Gene3D G3DSA:1.10.10.10 3 83 3.2E-28 T 13-10-2018 IPR036388 Winged helix-like DNA-binding domain superfamily TOPB45_0567 858b4cbf6bdbe6917d9f5e28528bbdc3 674 SUPERFAMILY SSF52540 36 296 5.72E-19 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0567 858b4cbf6bdbe6917d9f5e28528bbdc3 674 Pfam PF00350 Dynamin family 61 277 4.3E-19 T 13-10-2018 IPR022812 Dynamin superfamily TOPB45_0225 b3f6daf979087b6e372475098193fbaa 201 ProSitePatterns PS01081 TetR-type HTH domain signature. 27 57 - T 13-10-2018 IPR023772 DNA-binding HTH domain, TetR-type, conserved site TOPB45_0225 b3f6daf979087b6e372475098193fbaa 201 Gene3D G3DSA:1.10.357.10 58 201 3.4E-17 T 13-10-2018 TOPB45_0225 b3f6daf979087b6e372475098193fbaa 201 SUPERFAMILY SSF48498 88 200 2.58E-12 T 13-10-2018 IPR036271 Tetracyclin repressor-like, C-terminal domain superfamily TOPB45_0225 b3f6daf979087b6e372475098193fbaa 201 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 36 59 4.2E-11 T 13-10-2018 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TOPB45_0225 b3f6daf979087b6e372475098193fbaa 201 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 15 28 4.2E-11 T 13-10-2018 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TOPB45_0225 b3f6daf979087b6e372475098193fbaa 201 Gene3D G3DSA:1.10.10.60 3 57 1.4E-18 T 13-10-2018 TOPB45_0225 b3f6daf979087b6e372475098193fbaa 201 Pfam PF00440 Bacterial regulatory proteins, tetR family 15 61 1.2E-16 T 13-10-2018 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 TOPB45_0225 b3f6daf979087b6e372475098193fbaa 201 SUPERFAMILY SSF46689 3 66 3.28E-18 T 13-10-2018 IPR009057 Homeobox-like domain superfamily GO:0003677 TOPB45_1584 1029c350b8b9bca8dd6eaf07e3015a26 230 Hamap MF_00108 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase [ispD]. 1 222 38.381 T 13-10-2018 IPR001228 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase GO:0008299|GO:0050518 KEGG: 00900+2.7.7.60|MetaCyc: PWY-7560 TOPB45_1584 1029c350b8b9bca8dd6eaf07e3015a26 230 Gene3D G3DSA:3.90.550.10 2 226 6.8E-71 T 13-10-2018 IPR029044 Nucleotide-diphospho-sugar transferases TOPB45_1584 1029c350b8b9bca8dd6eaf07e3015a26 230 TIGRFAM TIGR00453 ispD: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 3 221 1.3E-66 T 13-10-2018 IPR001228 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase GO:0008299|GO:0050518 KEGG: 00900+2.7.7.60|MetaCyc: PWY-7560 TOPB45_1584 1029c350b8b9bca8dd6eaf07e3015a26 230 SUPERFAMILY SSF53448 1 222 1.45E-55 T 13-10-2018 IPR029044 Nucleotide-diphospho-sugar transferases TOPB45_1584 1029c350b8b9bca8dd6eaf07e3015a26 230 Pfam PF01128 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 2 221 1.7E-57 T 13-10-2018 IPR034683 Cytidylyltransferase IspD/TarI GO:0070567 KEGG: 00900+2.7.7.60|MetaCyc: PWY-7560 TOPB45_0611 305322f76bfb7eeaf703c5d2247bfa1e 310 Gene3D G3DSA:3.40.50.620 169 309 6.3E-26 T 13-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TOPB45_0611 305322f76bfb7eeaf703c5d2247bfa1e 310 Gene3D G3DSA:3.40.50.620 3 162 1.6E-25 T 13-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TOPB45_0611 305322f76bfb7eeaf703c5d2247bfa1e 310 SUPERFAMILY SSF52402 5 150 1.0E-18 T 13-10-2018 TOPB45_0611 305322f76bfb7eeaf703c5d2247bfa1e 310 PRINTS PR01438 Universal stress protein signature 170 188 1.0E-11 T 13-10-2018 IPR006015 Universal stress protein A TOPB45_0611 305322f76bfb7eeaf703c5d2247bfa1e 310 PRINTS PR01438 Universal stress protein signature 286 308 1.0E-11 T 13-10-2018 IPR006015 Universal stress protein A TOPB45_0611 305322f76bfb7eeaf703c5d2247bfa1e 310 PRINTS PR01438 Universal stress protein signature 268 280 1.0E-11 T 13-10-2018 IPR006015 Universal stress protein A TOPB45_0611 305322f76bfb7eeaf703c5d2247bfa1e 310 Pfam PF00582 Universal stress protein family 171 306 1.2E-20 T 13-10-2018 IPR006016 UspA TOPB45_0611 305322f76bfb7eeaf703c5d2247bfa1e 310 Pfam PF00582 Universal stress protein family 6 150 4.3E-18 T 13-10-2018 IPR006016 UspA TOPB45_0611 305322f76bfb7eeaf703c5d2247bfa1e 310 SUPERFAMILY SSF52402 171 303 1.76E-22 T 13-10-2018 TOPB45_0522 453f78e5ab6424f43891d2b04d15b128 147 Pfam PF01475 Ferric uptake regulator family 17 136 3.2E-29 T 13-10-2018 IPR002481 Ferric-uptake regulator GO:0003700|GO:0006355 TOPB45_0522 453f78e5ab6424f43891d2b04d15b128 147 SUPERFAMILY SSF46785 10 141 9.63E-33 T 13-10-2018 IPR036390 Winged helix DNA-binding domain superfamily TOPB45_0522 453f78e5ab6424f43891d2b04d15b128 147 Gene3D G3DSA:1.10.10.10 5 89 8.9E-26 T 13-10-2018 IPR036388 Winged helix-like DNA-binding domain superfamily TOPB45_0522 453f78e5ab6424f43891d2b04d15b128 147 Gene3D G3DSA:3.30.1490.190 91 146 5.9E-14 T 13-10-2018 TOPB45_0671 965064bcde3389c87300727f4fc52c57 253 Gene3D G3DSA:3.40.50.970 67 251 2.5E-18 T 13-10-2018 TOPB45_0671 965064bcde3389c87300727f4fc52c57 253 SUPERFAMILY SSF52518 16 247 2.18E-51 T 13-10-2018 IPR029061 Thiamin diphosphate-binding fold TOPB45_0671 965064bcde3389c87300727f4fc52c57 253 Pfam PF02775 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain 65 195 1.0E-21 T 13-10-2018 IPR011766 Thiamine pyrophosphate enzyme, C-terminal TPP-binding GO:0003824|GO:0030976 TOPB45_0974 0e7825b247f28671ee40701e878b2efd 239 Pfam PF02633 Creatinine amidohydrolase 5 229 5.4E-52 T 13-10-2018 IPR003785 Creatininase/formamide hydrolase KEGG: 00740+3.5.1.102|MetaCyc: PWY-6167 TOPB45_0974 0e7825b247f28671ee40701e878b2efd 239 Gene3D G3DSA:3.40.50.10310 1 235 6.2E-62 T 13-10-2018 IPR024087 Creatininase-like superfamily KEGG: 00740+3.5.1.102|MetaCyc: PWY-6167 TOPB45_0974 0e7825b247f28671ee40701e878b2efd 239 SUPERFAMILY SSF102215 1 232 8.24E-54 T 13-10-2018 IPR024087 Creatininase-like superfamily KEGG: 00740+3.5.1.102|MetaCyc: PWY-6167 TOPB45_0384 4ff6c47d07b895eaff3bfd383f93049f 409 Gene3D G3DSA:3.90.10.10 110 181 2.3E-6 T 13-10-2018 TOPB45_0384 4ff6c47d07b895eaff3bfd383f93049f 409 Pfam PF13447 Seven times multi-haem cytochrome CxxCH 270 331 2.4E-8 T 13-10-2018 TOPB45_0384 4ff6c47d07b895eaff3bfd383f93049f 409 Pfam PF13447 Seven times multi-haem cytochrome CxxCH 28 211 1.9E-15 T 13-10-2018 TOPB45_0384 4ff6c47d07b895eaff3bfd383f93049f 409 Gene3D G3DSA:3.90.10.10 18 88 2.4E-5 T 13-10-2018 TOPB45_0384 4ff6c47d07b895eaff3bfd383f93049f 409 SUPERFAMILY SSF48695 24 399 5.13E-60 T 13-10-2018 IPR036280 Multiheme cytochrome superfamily TOPB45_0094 efc548eba40d6256de172dab87bcda77 174 Gene3D G3DSA:1.20.120.1200 5 168 2.7E-33 T 13-10-2018 TOPB45_0094 efc548eba40d6256de172dab87bcda77 174 Pfam PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 18 166 1.4E-27 T 13-10-2018 IPR001457 NADH:ubiquinone/plastoquinone oxidoreductase, chain 6 GO:0008137|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 TOPB45_0655 227986abb6eb2388ea0f87682e2d8539 245 Hamap MF_00607 Ribosomal RNA small subunit methyltransferase A [rsmA]. 1 242 41.281 T 13-10-2018 IPR011530 Ribosomal RNA adenine dimethylase GO:0000179|GO:0006364 TOPB45_0655 227986abb6eb2388ea0f87682e2d8539 245 Gene3D G3DSA:1.10.8.100 183 243 1.0E-12 T 13-10-2018 IPR023165 rRNA adenine dimethylase-like Reactome: R-HSA-2151201|Reactome: R-HSA-6793080 TOPB45_0655 227986abb6eb2388ea0f87682e2d8539 245 ProSitePatterns PS01131 Ribosomal RNA adenine dimethylases signature. 32 60 - T 13-10-2018 IPR020596 Ribosomal RNA adenine methylase transferase, conserved site GO:0000154|GO:0000179|GO:0008649 TOPB45_0655 227986abb6eb2388ea0f87682e2d8539 245 SMART SM00650 16 181 1.8E-54 T 13-10-2018 IPR020598 Ribosomal RNA adenine methylase transferase, N-terminal GO:0000154|GO:0000179|GO:0008649 TOPB45_0655 227986abb6eb2388ea0f87682e2d8539 245 TIGRFAM TIGR00755 ksgA: ribosomal RNA small subunit methyltransferase A 2 239 2.3E-65 T 13-10-2018 IPR011530 Ribosomal RNA adenine dimethylase GO:0000179|GO:0006364 TOPB45_0655 227986abb6eb2388ea0f87682e2d8539 245 Pfam PF00398 Ribosomal RNA adenine dimethylase 3 243 4.1E-46 T 13-10-2018 IPR001737 Ribosomal RNA adenine methyltransferase KsgA/Erm TOPB45_0655 227986abb6eb2388ea0f87682e2d8539 245 Gene3D G3DSA:3.40.50.150 1 181 4.4E-54 T 13-10-2018 TOPB45_0655 227986abb6eb2388ea0f87682e2d8539 245 SUPERFAMILY SSF53335 3 243 6.53E-58 T 13-10-2018 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TOPB45_0790 a51463135a68433b349b3f1f9a491c23 442 Pfam PF13231 Dolichyl-phosphate-mannose-protein mannosyltransferase 64 205 3.8E-11 T 13-10-2018 IPR038731 Glycosyltransferase RgtA/B/C/D-like TOPB45_1610 b5ab5f6cdf387b65fe2f75da33f44c14 306 Gene3D G3DSA:3.50.50.60 5 300 1.3E-113 T 13-10-2018 IPR036188 FAD/NAD(P)-binding domain superfamily TOPB45_1610 b5ab5f6cdf387b65fe2f75da33f44c14 306 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 228 244 1.4E-33 T 13-10-2018 TOPB45_1610 b5ab5f6cdf387b65fe2f75da33f44c14 306 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 102 120 1.4E-33 T 13-10-2018 TOPB45_1610 b5ab5f6cdf387b65fe2f75da33f44c14 306 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 144 162 1.4E-33 T 13-10-2018 TOPB45_1610 b5ab5f6cdf387b65fe2f75da33f44c14 306 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 4 23 1.4E-33 T 13-10-2018 TOPB45_1610 b5ab5f6cdf387b65fe2f75da33f44c14 306 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 254 276 1.4E-33 T 13-10-2018 TOPB45_1610 b5ab5f6cdf387b65fe2f75da33f44c14 306 Gene3D G3DSA:3.50.50.60 119 241 1.3E-113 T 13-10-2018 IPR036188 FAD/NAD(P)-binding domain superfamily TOPB45_1610 b5ab5f6cdf387b65fe2f75da33f44c14 306 TIGRFAM TIGR01292 TRX_reduct: thioredoxin-disulfide reductase 2 301 2.1E-117 T 13-10-2018 IPR005982 Thioredoxin reductase GO:0004791|GO:0005737|GO:0019430|GO:0055114 KEGG: 00450+1.8.1.9 TOPB45_1610 b5ab5f6cdf387b65fe2f75da33f44c14 306 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 3 25 6.3E-67 T 13-10-2018 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TOPB45_1610 b5ab5f6cdf387b65fe2f75da33f44c14 306 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 103 111 6.3E-67 T 13-10-2018 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TOPB45_1610 b5ab5f6cdf387b65fe2f75da33f44c14 306 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 125 137 6.3E-67 T 13-10-2018 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TOPB45_1610 b5ab5f6cdf387b65fe2f75da33f44c14 306 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 230 251 6.3E-67 T 13-10-2018 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TOPB45_1610 b5ab5f6cdf387b65fe2f75da33f44c14 306 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 36 51 6.3E-67 T 13-10-2018 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TOPB45_1610 b5ab5f6cdf387b65fe2f75da33f44c14 306 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 192 208 6.3E-67 T 13-10-2018 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TOPB45_1610 b5ab5f6cdf387b65fe2f75da33f44c14 306 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 264 282 6.3E-67 T 13-10-2018 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TOPB45_1610 b5ab5f6cdf387b65fe2f75da33f44c14 306 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 57 67 6.3E-67 T 13-10-2018 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TOPB45_1610 b5ab5f6cdf387b65fe2f75da33f44c14 306 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 140 164 6.3E-67 T 13-10-2018 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 TOPB45_1610 b5ab5f6cdf387b65fe2f75da33f44c14 306 ProSitePatterns PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site. 132 152 - T 13-10-2018 IPR008255 Pyridine nucleotide-disulphide oxidoreductase, class-II, active site GO:0016491|GO:0055114 TOPB45_1610 b5ab5f6cdf387b65fe2f75da33f44c14 306 SUPERFAMILY SSF51905 2 301 1.17E-48 T 13-10-2018 IPR036188 FAD/NAD(P)-binding domain superfamily TOPB45_1610 b5ab5f6cdf387b65fe2f75da33f44c14 306 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 2 290 1.0E-50 T 13-10-2018 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 TOPB45_1615 cccc234266dbba397ca829a8a6b6cbd9 94 Pfam PF02416 mttA/Hcf106 family 4 50 1.2E-10 T 13-10-2018 IPR003369 Sec-independent protein translocase protein TatA/B/E GO:0008565|GO:0015031 TOPB45_1615 cccc234266dbba397ca829a8a6b6cbd9 94 TIGRFAM TIGR01410 tatB: twin arginine-targeting protein translocase TatB 2 73 1.6E-17 T 13-10-2018 IPR018448 Twin-arginine translocation protein TatB GO:0016020|GO:0043953 TOPB45_1615 cccc234266dbba397ca829a8a6b6cbd9 94 PRINTS PR01506 Bacterial sec-independent translocation TatB protein signature 40 58 2.1E-11 T 13-10-2018 TOPB45_1615 cccc234266dbba397ca829a8a6b6cbd9 94 PRINTS PR01506 Bacterial sec-independent translocation TatB protein signature 1 21 2.1E-11 T 13-10-2018 TOPB45_1615 cccc234266dbba397ca829a8a6b6cbd9 94 PRINTS PR01506 Bacterial sec-independent translocation TatB protein signature 21 40 2.1E-11 T 13-10-2018 TOPB45_1036 660ed503be76a8b007b9fe6c57962eb8 298 Pfam PF00696 Amino acid kinase family 25 271 1.8E-48 T 13-10-2018 IPR001048 Aspartate/glutamate/uridylate kinase Reactome: R-HSA-70614 TOPB45_1036 660ed503be76a8b007b9fe6c57962eb8 298 PRINTS PR00474 Glutamate 5-kinase family signature 244 264 2.9E-9 T 13-10-2018 IPR001057 Glutamate/acetylglutamate kinase Reactome: R-HSA-70614 TOPB45_1036 660ed503be76a8b007b9fe6c57962eb8 298 PRINTS PR00474 Glutamate 5-kinase family signature 194 221 2.9E-9 T 13-10-2018 IPR001057 Glutamate/acetylglutamate kinase Reactome: R-HSA-70614 TOPB45_1036 660ed503be76a8b007b9fe6c57962eb8 298 PRINTS PR00474 Glutamate 5-kinase family signature 56 70 2.9E-9 T 13-10-2018 IPR001057 Glutamate/acetylglutamate kinase Reactome: R-HSA-70614 TOPB45_1036 660ed503be76a8b007b9fe6c57962eb8 298 TIGRFAM TIGR00761 argB: acetylglutamate kinase 27 269 9.8E-83 T 13-10-2018 IPR004662 Acetylglutamate kinase family GO:0005737 KEGG: 00220+2.7.2.8|MetaCyc: PWY-5154|MetaCyc: PWY-7400 TOPB45_1036 660ed503be76a8b007b9fe6c57962eb8 298 Hamap MF_00082 Acetylglutamate kinase [argB]. 24 287 52.09 T 13-10-2018 IPR037528 Acetylglutamate kinase ArgB GO:0003991|GO:0006526 KEGG: 00220+2.7.2.8|MetaCyc: PWY-5154|MetaCyc: PWY-7400 TOPB45_1036 660ed503be76a8b007b9fe6c57962eb8 298 SUPERFAMILY SSF53633 2 294 9.69E-96 T 13-10-2018 IPR036393 Acetylglutamate kinase-like superfamily TOPB45_1036 660ed503be76a8b007b9fe6c57962eb8 298 PIRSF PIRSF000728 7 294 9.5E-111 T 13-10-2018 IPR004662 Acetylglutamate kinase family GO:0005737 KEGG: 00220+2.7.2.8|MetaCyc: PWY-5154|MetaCyc: PWY-7400 TOPB45_1036 660ed503be76a8b007b9fe6c57962eb8 298 Gene3D G3DSA:3.40.1160.10 4 294 4.9E-99 T 13-10-2018 IPR036393 Acetylglutamate kinase-like superfamily TOPB45_1113 bbe503beddee41f384ef6c64d7706419 396 TIGRFAM TIGR01899 cas_TM1807_csm5: CRISPR type III-A/MTUBE-associated RAMP protein Csm5 3 379 2.6E-28 T 13-10-2018 IPR010173 CRISPR-associated protein, TM1807 TOPB45_1113 bbe503beddee41f384ef6c64d7706419 396 Pfam PF03787 RAMP superfamily 3 299 1.0E-15 T 13-10-2018 IPR005537 CRISPR type III-associated RAMP protein TOPB45_0828 edf9cb1a6f1ab46e7f60512e4881dd39 198 SMART SM00471 31 144 5.0E-9 T 13-10-2018 IPR003607 HD/PDEase domain TOPB45_0828 edf9cb1a6f1ab46e7f60512e4881dd39 198 SUPERFAMILY SSF109604 5 182 9.74E-33 T 13-10-2018 TOPB45_0828 edf9cb1a6f1ab46e7f60512e4881dd39 198 Gene3D G3DSA:1.10.3210.10 1 182 2.1E-44 T 13-10-2018 TOPB45_0828 edf9cb1a6f1ab46e7f60512e4881dd39 198 Pfam PF13023 HD domain 17 155 1.1E-26 T 13-10-2018 IPR006674 HD domain TOPB45_0355 48565ed2e02769906f7cbaf95b5de2a7 330 TIGRFAM TIGR01181 dTDP_gluc_dehyt: dTDP-glucose 4,6-dehydratase 2 314 4.7E-135 T 13-10-2018 IPR005888 dTDP-glucose 4,6-dehydratase GO:0008460|GO:0009225 KEGG: 00521+4.2.1.46|KEGG: 00523+4.2.1.46|KEGG: 00525+4.2.1.46|MetaCyc: PWY-3221|MetaCyc: PWY-6808|MetaCyc: PWY-6942|MetaCyc: PWY-6953|MetaCyc: PWY-6973|MetaCyc: PWY-6974|MetaCyc: PWY-6976|MetaCyc: PWY-7104|MetaCyc: PWY-7301|MetaCyc: PWY-7312|MetaCyc: PWY-7315|MetaCyc: PWY-7316|MetaCyc: PWY-7318|MetaCyc: PWY-7413|MetaCyc: PWY-7414|MetaCyc: PWY-7440|MetaCyc: PWY-7657|MetaCyc: PWY-7688|MetaCyc: PWY-7814 TOPB45_0355 48565ed2e02769906f7cbaf95b5de2a7 330 SUPERFAMILY SSF51735 1 315 8.24E-104 T 13-10-2018 IPR036291 NAD(P)-binding domain superfamily TOPB45_0355 48565ed2e02769906f7cbaf95b5de2a7 330 Pfam PF16363 GDP-mannose 4,6 dehydratase 4 300 5.5E-86 T 13-10-2018 IPR016040 NAD(P)-binding domain TOPB45_0355 48565ed2e02769906f7cbaf95b5de2a7 330 Gene3D G3DSA:3.90.25.10 188 309 7.7E-125 T 13-10-2018 TOPB45_0355 48565ed2e02769906f7cbaf95b5de2a7 330 Gene3D G3DSA:3.40.50.720 2 301 7.7E-125 T 13-10-2018 TOPB45_1547 698de6c61ab3bd503974ca7b06827135 293 ProSitePatterns PS00153 ATP synthase gamma subunit signature. 276 289 - T 13-10-2018 IPR023632 ATP synthase, F1 complex, gamma subunit conserved site Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_1547 698de6c61ab3bd503974ca7b06827135 293 Gene3D G3DSA:1.10.287.80 6 286 2.9E-94 T 13-10-2018 TOPB45_1547 698de6c61ab3bd503974ca7b06827135 293 Hamap MF_00815 ATP synthase gamma chain [atpG]. 1 290 33.484 T 13-10-2018 IPR000131 ATP synthase, F1 complex, gamma subunit GO:0015986|GO:0045261|GO:0046933 Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_1547 698de6c61ab3bd503974ca7b06827135 293 PRINTS PR00126 ATP synthase gamma subunit signature 167 184 2.1E-33 T 13-10-2018 IPR000131 ATP synthase, F1 complex, gamma subunit GO:0015986|GO:0045261|GO:0046933 Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_1547 698de6c61ab3bd503974ca7b06827135 293 PRINTS PR00126 ATP synthase gamma subunit signature 237 256 2.1E-33 T 13-10-2018 IPR000131 ATP synthase, F1 complex, gamma subunit GO:0015986|GO:0045261|GO:0046933 Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_1547 698de6c61ab3bd503974ca7b06827135 293 PRINTS PR00126 ATP synthase gamma subunit signature 268 289 2.1E-33 T 13-10-2018 IPR000131 ATP synthase, F1 complex, gamma subunit GO:0015986|GO:0045261|GO:0046933 Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_1547 698de6c61ab3bd503974ca7b06827135 293 PRINTS PR00126 ATP synthase gamma subunit signature 75 94 2.1E-33 T 13-10-2018 IPR000131 ATP synthase, F1 complex, gamma subunit GO:0015986|GO:0045261|GO:0046933 Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_1547 698de6c61ab3bd503974ca7b06827135 293 Gene3D G3DSA:3.40.1380.10 62 209 2.9E-94 T 13-10-2018 TOPB45_1547 698de6c61ab3bd503974ca7b06827135 293 Pfam PF00231 ATP synthase 4 290 4.0E-93 T 13-10-2018 IPR000131 ATP synthase, F1 complex, gamma subunit GO:0015986|GO:0045261|GO:0046933 Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_1547 698de6c61ab3bd503974ca7b06827135 293 SUPERFAMILY SSF52943 4 290 6.41E-86 T 13-10-2018 IPR035968 ATP synthase, F1 complex, gamma subunit superfamily GO:0015986|GO:0045261|GO:0046933 Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_1547 698de6c61ab3bd503974ca7b06827135 293 TIGRFAM TIGR01146 ATPsyn_F1gamma: ATP synthase F1, gamma subunit 1 290 1.3E-93 T 13-10-2018 IPR000131 ATP synthase, F1 complex, gamma subunit GO:0015986|GO:0045261|GO:0046933 Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_1070 86df400106439ef83dd92140cc4e92f5 394 Gene3D G3DSA:2.40.50.100 55 253 1.6E-81 T 13-10-2018 TOPB45_1070 86df400106439ef83dd92140cc4e92f5 394 TIGRFAM TIGR01730 RND_mfp: efflux transporter, RND family, MFP subunit 188 391 2.6E-38 T 13-10-2018 IPR006143 RND efflux pump, membrane fusion protein GO:0005215|GO:0016020|GO:0055085 TOPB45_1070 86df400106439ef83dd92140cc4e92f5 394 SUPERFAMILY SSF111369 188 275 6.15E-11 T 13-10-2018 TOPB45_1070 86df400106439ef83dd92140cc4e92f5 394 Gene3D G3DSA:2.40.420.20 38 391 1.6E-81 T 13-10-2018 TOPB45_1070 86df400106439ef83dd92140cc4e92f5 394 Gene3D G3DSA:2.40.30.170 42 333 1.6E-81 T 13-10-2018 TOPB45_1070 86df400106439ef83dd92140cc4e92f5 394 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion 158 296 6.3E-17 T 13-10-2018 IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain TOPB45_1070 86df400106439ef83dd92140cc4e92f5 394 Pfam PF13533 Biotin-lipoyl like 57 102 7.4E-13 T 13-10-2018 IPR039562 Membrane fusion protein, biotin-lipoyl like domain TOPB45_1070 86df400106439ef83dd92140cc4e92f5 394 Gene3D G3DSA:1.10.287.470 89 216 1.6E-81 T 13-10-2018 TOPB45_1070 86df400106439ef83dd92140cc4e92f5 394 SUPERFAMILY SSF111369 56 126 2.35E-8 T 13-10-2018 TOPB45_0999 8690b7a881c72a6a64c73d150449a7b8 169 Pfam PF00731 AIR carboxylase 2 148 5.1E-68 T 13-10-2018 IPR000031 PurE domain GO:0006189 Reactome: R-HSA-73817 TOPB45_0999 8690b7a881c72a6a64c73d150449a7b8 169 Gene3D G3DSA:3.40.50.7700 1 169 2.8E-78 T 13-10-2018 IPR035893 PurE domain superfamily Reactome: R-HSA-73817 TOPB45_0999 8690b7a881c72a6a64c73d150449a7b8 169 PIRSF PIRSF001338 1 161 3.4E-73 T 13-10-2018 IPR024694 PurE, prokaryotic type GO:0006189 KEGG: 00230+5.4.99.18|MetaCyc: PWY-6123|MetaCyc: PWY-7234 TOPB45_0999 8690b7a881c72a6a64c73d150449a7b8 169 SMART SM01001 1 150 1.4E-98 T 13-10-2018 IPR000031 PurE domain GO:0006189 Reactome: R-HSA-73817 TOPB45_0999 8690b7a881c72a6a64c73d150449a7b8 169 TIGRFAM TIGR01162 purE: phosphoribosylaminoimidazole carboxylase, catalytic subunit 3 158 1.8E-68 T 13-10-2018 IPR000031 PurE domain GO:0006189 Reactome: R-HSA-73817 TOPB45_0999 8690b7a881c72a6a64c73d150449a7b8 169 Hamap MF_01929 N5-carboxyaminoimidazole ribonucleotide mutase [purE]. 3 154 33.847 T 13-10-2018 IPR033747 Class I PurE TOPB45_0999 8690b7a881c72a6a64c73d150449a7b8 169 SUPERFAMILY SSF52255 1 166 5.1E-68 T 13-10-2018 IPR035893 PurE domain superfamily Reactome: R-HSA-73817 TOPB45_0396 2136660f2e674ffa0025d666ae252e6f 306 SUPERFAMILY SSF51730 6 302 3.73E-82 T 13-10-2018 IPR029041 FAD-linked oxidoreductase-like TOPB45_0396 2136660f2e674ffa0025d666ae252e6f 306 Pfam PF02219 Methylenetetrahydrofolate reductase 7 298 3.3E-48 T 13-10-2018 IPR003171 Methylenetetrahydrofolate reductase GO:0004489|GO:0006555|GO:0055114 KEGG: 00670+1.5.1.20|KEGG: 00720+1.5.1.20|MetaCyc: PWY-2201|MetaCyc: PWY-3841|Reactome: R-HSA-196757 TOPB45_0396 2136660f2e674ffa0025d666ae252e6f 306 Gene3D G3DSA:3.20.20.220 7 303 1.3E-68 T 13-10-2018 TOPB45_1402 271770c2cdef89d74e2f7c853364f39c 77 TIGRFAM TIGR01411 tatAE: twin arginine-targeting protein translocase, TatA/E family 5 48 5.6E-16 T 13-10-2018 IPR006312 Sec-independent protein translocase protein TatA/E GO:0005886|GO:0008565|GO:0009306|GO:0015031|GO:0016021 TOPB45_1402 271770c2cdef89d74e2f7c853364f39c 77 Hamap MF_00236 Sec-independent protein translocase protein TatA [tatA]. 2 76 17.496 T 13-10-2018 IPR006312 Sec-independent protein translocase protein TatA/E GO:0005886|GO:0008565|GO:0009306|GO:0015031|GO:0016021 TOPB45_1402 271770c2cdef89d74e2f7c853364f39c 77 Pfam PF02416 mttA/Hcf106 family 5 52 4.0E-18 T 13-10-2018 IPR003369 Sec-independent protein translocase protein TatA/B/E GO:0008565|GO:0015031 TOPB45_1210 9786a53ff70e8fba4b470ed2d40db131 212 Pfam PF04350 Pilus assembly protein, PilO 50 186 1.0E-25 T 13-10-2018 IPR007445 Pilus assembly protein, PilO TOPB45_1210 9786a53ff70e8fba4b470ed2d40db131 212 Gene3D G3DSA:3.30.70.60 92 200 8.1E-23 T 13-10-2018 IPR014717 Translation elongation factor EF1B/ribosomal protein S6 TOPB45_0856 89b28e542db59a39377a9b9bfecfc017 172 Pfam PF01613 Flavin reductase like domain 8 140 1.1E-18 T 13-10-2018 IPR002563 Flavin reductase like domain GO:0010181 TOPB45_0856 89b28e542db59a39377a9b9bfecfc017 172 SUPERFAMILY SSF50475 2 141 6.87E-28 T 13-10-2018 TOPB45_0856 89b28e542db59a39377a9b9bfecfc017 172 Gene3D G3DSA:2.30.110.10 2 168 1.1E-36 T 13-10-2018 IPR012349 FMN-binding split barrel GO:0048037 TOPB45_0856 89b28e542db59a39377a9b9bfecfc017 172 SMART SM00903 5 146 8.4E-9 T 13-10-2018 IPR002563 Flavin reductase like domain GO:0010181 TOPB45_0873 dc6634f402062a87592a8ffb0bd42be3 277 Gene3D G3DSA:3.40.190.10 26 143 5.4E-10 T 13-10-2018 TOPB45_0873 dc6634f402062a87592a8ffb0bd42be3 277 SUPERFAMILY SSF53850 27 274 1.02E-36 T 13-10-2018 TOPB45_0873 dc6634f402062a87592a8ffb0bd42be3 277 Pfam PF13531 Bacterial extracellular solute-binding protein 29 272 3.8E-37 T 13-10-2018 TOPB45_0873 dc6634f402062a87592a8ffb0bd42be3 277 Gene3D G3DSA:3.40.190.10 194 277 5.1E-12 T 13-10-2018 TOPB45_1596 8467e8e2e00c2fc03cacba7c625df3e0 164 PRINTS PR01576 Peptide deformylase signature 30 59 1.7E-35 T 13-10-2018 IPR023635 Peptide deformylase TOPB45_1596 8467e8e2e00c2fc03cacba7c625df3e0 164 PRINTS PR01576 Peptide deformylase signature 88 99 1.7E-35 T 13-10-2018 IPR023635 Peptide deformylase TOPB45_1596 8467e8e2e00c2fc03cacba7c625df3e0 164 PRINTS PR01576 Peptide deformylase signature 100 118 1.7E-35 T 13-10-2018 IPR023635 Peptide deformylase TOPB45_1596 8467e8e2e00c2fc03cacba7c625df3e0 164 PRINTS PR01576 Peptide deformylase signature 119 148 1.7E-35 T 13-10-2018 IPR023635 Peptide deformylase TOPB45_1596 8467e8e2e00c2fc03cacba7c625df3e0 164 PIRSF PIRSF004749 1 164 5.0E-55 T 13-10-2018 IPR023635 Peptide deformylase TOPB45_1596 8467e8e2e00c2fc03cacba7c625df3e0 164 SUPERFAMILY SSF56420 2 162 2.62E-59 T 13-10-2018 IPR036821 Peptide deformylase superfamily TOPB45_1596 8467e8e2e00c2fc03cacba7c625df3e0 164 Gene3D G3DSA:3.90.45.10 1 164 1.9E-62 T 13-10-2018 IPR036821 Peptide deformylase superfamily TOPB45_1596 8467e8e2e00c2fc03cacba7c625df3e0 164 TIGRFAM TIGR00079 pept_deformyl: peptide deformylase 1 159 1.2E-51 T 13-10-2018 IPR023635 Peptide deformylase TOPB45_1596 8467e8e2e00c2fc03cacba7c625df3e0 164 Pfam PF01327 Polypeptide deformylase 2 151 2.4E-54 T 13-10-2018 IPR023635 Peptide deformylase TOPB45_1596 8467e8e2e00c2fc03cacba7c625df3e0 164 Hamap MF_00163 Peptide deformylase [def]. 1 161 27.724 T 13-10-2018 IPR023635 Peptide deformylase TOPB45_0754 4477e2d48f9096ff4896ea4b4c7eb52c 210 Hamap MF_01328_B 50S ribosomal protein L4 [rplD]. 11 209 34.277 T 13-10-2018 IPR013005 50S ribosomal protein uL4 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0754 4477e2d48f9096ff4896ea4b4c7eb52c 210 Pfam PF00573 Ribosomal protein L4/L1 family 19 207 2.3E-65 T 13-10-2018 IPR002136 Ribosomal protein L4/L1e GO:0003735|GO:0005840|GO:0006412 TOPB45_0754 4477e2d48f9096ff4896ea4b4c7eb52c 210 SUPERFAMILY SSF52166 5 208 5.23E-76 T 13-10-2018 IPR023574 Ribosomal protein L4 domain superfamily GO:0003735|GO:0005840|GO:0006412 TOPB45_0754 4477e2d48f9096ff4896ea4b4c7eb52c 210 Gene3D G3DSA:3.40.1370.10 1 210 4.1E-77 T 13-10-2018 IPR023574 Ribosomal protein L4 domain superfamily GO:0003735|GO:0005840|GO:0006412 TOPB45_0754 4477e2d48f9096ff4896ea4b4c7eb52c 210 TIGRFAM TIGR03953 rplD_bact: 50S ribosomal protein uL4 19 206 3.6E-74 T 13-10-2018 IPR013005 50S ribosomal protein uL4 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0594 6f908c43f5c63ec66be8cf23883981bb 515 Pfam PF02538 Hydantoinase B/oxoprolinase 3 513 2.0E-196 T 13-10-2018 IPR003692 Hydantoinase B/oxoprolinase GO:0003824 Reactome: R-HSA-174403|Reactome: R-HSA-5578998 TOPB45_0670 531589e8d7fd0e0468d62baeeb2bf537 188 Pfam PF01558 Pyruvate ferredoxin/flavodoxin oxidoreductase 11 180 1.0E-36 T 13-10-2018 IPR019752 Pyruvate/ketoisovalerate oxidoreductase, catalytic domain GO:0016903|GO:0055114 TOPB45_0670 531589e8d7fd0e0468d62baeeb2bf537 188 Gene3D G3DSA:3.40.920.10 1 188 1.2E-54 T 13-10-2018 IPR002869 Pyruvate-flavodoxin oxidoreductase, central domain GO:0016491|GO:0055114 TOPB45_0670 531589e8d7fd0e0468d62baeeb2bf537 188 SUPERFAMILY SSF53323 3 185 9.29E-41 T 13-10-2018 IPR002869 Pyruvate-flavodoxin oxidoreductase, central domain GO:0016491|GO:0055114 TOPB45_0113 cc2c7f521f486ad2a8ecc61539d0a0ce 374 SMART SM00471 188 325 4.7E-6 T 13-10-2018 IPR003607 HD/PDEase domain TOPB45_0113 cc2c7f521f486ad2a8ecc61539d0a0ce 374 Pfam PF01966 HD domain 195 315 2.1E-19 T 13-10-2018 IPR006674 HD domain TOPB45_0113 cc2c7f521f486ad2a8ecc61539d0a0ce 374 SUPERFAMILY SSF109604 169 355 1.54E-46 T 13-10-2018 TOPB45_0113 cc2c7f521f486ad2a8ecc61539d0a0ce 374 Gene3D G3DSA:1.10.3210.10 167 369 1.9E-81 T 13-10-2018 TOPB45_0113 cc2c7f521f486ad2a8ecc61539d0a0ce 374 Pfam PF00072 Response regulator receiver domain 14 125 1.0E-27 T 13-10-2018 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TOPB45_0113 cc2c7f521f486ad2a8ecc61539d0a0ce 374 SUPERFAMILY SSF52172 10 163 5.12E-38 T 13-10-2018 IPR011006 CheY-like superfamily TOPB45_0113 cc2c7f521f486ad2a8ecc61539d0a0ce 374 SMART SM00448 12 125 4.1E-38 T 13-10-2018 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 TOPB45_0113 cc2c7f521f486ad2a8ecc61539d0a0ce 374 Gene3D G3DSA:3.40.50.2300 4 142 9.5E-36 T 13-10-2018 TOPB45_0694 648e6cca64abb9a24cf37ff770d2e051 287 ProSitePatterns PS00379 CDP-alcohol phosphatidyltransferases signature. 50 72 - T 13-10-2018 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 TOPB45_0694 648e6cca64abb9a24cf37ff770d2e051 287 Gene3D G3DSA:1.20.120.1760 1 175 1.2E-16 T 13-10-2018 TOPB45_0694 648e6cca64abb9a24cf37ff770d2e051 287 TIGRFAM TIGR00560 pgsA: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 5 176 1.0E-35 T 13-10-2018 IPR004570 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase GO:0008444|GO:0008654|GO:0016021 KEGG: 00564+2.7.8.5|MetaCyc: PWY-5269|MetaCyc: PWY-5668|MetaCyc: PWY-7817 TOPB45_0694 648e6cca64abb9a24cf37ff770d2e051 287 Pfam PF01066 CDP-alcohol phosphatidyltransferase 6 72 5.3E-14 T 13-10-2018 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 TOPB45_0525 8c9cade6ea7d8a92998c61eebfd239fe 343 PIRSF PIRSF002756 14 342 9.0E-114 T 13-10-2018 IPR005673 Phosphate ABC transporter, substrate-binding protein PstS GO:0035435|GO:0042301|GO:0043190 TOPB45_0525 8c9cade6ea7d8a92998c61eebfd239fe 343 SUPERFAMILY SSF53850 33 341 2.11E-101 T 13-10-2018 TOPB45_0525 8c9cade6ea7d8a92998c61eebfd239fe 343 Gene3D G3DSA:3.40.190.10 34 328 8.1E-118 T 13-10-2018 TOPB45_0525 8c9cade6ea7d8a92998c61eebfd239fe 343 Gene3D G3DSA:3.40.190.10 107 283 8.1E-118 T 13-10-2018 TOPB45_0525 8c9cade6ea7d8a92998c61eebfd239fe 343 Pfam PF12849 PBP superfamily domain 33 311 7.4E-59 T 13-10-2018 IPR024370 PBP domain TOPB45_0525 8c9cade6ea7d8a92998c61eebfd239fe 343 TIGRFAM TIGR00975 3a0107s03: phosphate ABC transporter, phosphate-binding protein PstS 33 339 5.1E-115 T 13-10-2018 IPR005673 Phosphate ABC transporter, substrate-binding protein PstS GO:0035435|GO:0042301|GO:0043190 TOPB45_1481 b2a593111373207710804d629988d83e 423 Gene3D G3DSA:1.20.1250.20 6 421 2.7E-59 T 13-10-2018 TOPB45_1481 b2a593111373207710804d629988d83e 423 ProSitePatterns PS00217 Sugar transport proteins signature 2. 118 143 - T 13-10-2018 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 TOPB45_1481 b2a593111373207710804d629988d83e 423 Pfam PF07690 Major Facilitator Superfamily 53 277 1.2E-20 T 13-10-2018 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 TOPB45_1481 b2a593111373207710804d629988d83e 423 SUPERFAMILY SSF103473 8 419 1.7E-57 T 13-10-2018 IPR036259 MFS transporter superfamily TOPB45_1481 b2a593111373207710804d629988d83e 423 ProSitePatterns PS00216 Sugar transport proteins signature 1. 287 303 - T 13-10-2018 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 TOPB45_1419 20ba087fb20473d07c58d25b2067f3d3 112 Pfam PF17253 Family of unknown function (DUF5320) 1 106 4.9E-34 T 13-10-2018 IPR035205 Protein of unknown function DUF5320 TOPB45_1419 20ba087fb20473d07c58d25b2067f3d3 112 ProDom PD050957 AF2391 PREDICTED 1 33 6.0E-9 T 13-10-2018 TOPB45_0020 0dfcdb744dbeaf5dc18c713dcdc97a5d 242 SUPERFAMILY SSF53335 12 193 2.69E-32 T 13-10-2018 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TOPB45_0020 0dfcdb744dbeaf5dc18c713dcdc97a5d 242 Pfam PF05175 Methyltransferase small domain 29 123 5.1E-11 T 13-10-2018 IPR007848 Methyltransferase small domain GO:0008168 TOPB45_0020 0dfcdb744dbeaf5dc18c713dcdc97a5d 242 ProSitePatterns PS00092 N-6 Adenine-specific DNA methylases signature. 112 118 - T 13-10-2018 IPR002052 DNA methylase, N-6 adenine-specific, conserved site GO:0003676|GO:0008168|GO:0032259 TOPB45_0020 0dfcdb744dbeaf5dc18c713dcdc97a5d 242 Gene3D G3DSA:3.40.50.150 6 241 6.7E-61 T 13-10-2018 TOPB45_0016 4c76024db9f03b0a89161c6bf83989f1 79 ProDom PD000887 CARRIER ACYL PHOSPHOPANTETHEINE ACP ACID FATTY BIOSYNTHESIS LIPID SYNTHESIS CHLOROPLAST 34 75 6.0E-9 T 13-10-2018 IPR003231 Acyl carrier protein (ACP) GO:0006633 Reactome: R-HSA-389661|Reactome: R-HSA-611105|Reactome: R-HSA-6799198|Reactome: R-HSA-77289 TOPB45_0016 4c76024db9f03b0a89161c6bf83989f1 79 SUPERFAMILY SSF47336 3 77 9.81E-24 T 13-10-2018 IPR036736 ACP-like superfamily TOPB45_0016 4c76024db9f03b0a89161c6bf83989f1 79 Gene3D G3DSA:1.10.1200.10 1 76 1.1E-28 T 13-10-2018 IPR036736 ACP-like superfamily TOPB45_0016 4c76024db9f03b0a89161c6bf83989f1 79 ProSitePatterns PS00012 Phosphopantetheine attachment site. 31 46 - T 13-10-2018 IPR006162 Phosphopantetheine attachment site TOPB45_0016 4c76024db9f03b0a89161c6bf83989f1 79 Pfam PF00550 Phosphopantetheine attachment site 5 72 6.9E-17 T 13-10-2018 IPR009081 Phosphopantetheine binding ACP domain TOPB45_0016 4c76024db9f03b0a89161c6bf83989f1 79 Hamap MF_01217 Acyl carrier protein [acpP]. 2 76 21.696 T 13-10-2018 IPR003231 Acyl carrier protein (ACP) GO:0006633 Reactome: R-HSA-389661|Reactome: R-HSA-611105|Reactome: R-HSA-6799198|Reactome: R-HSA-77289 TOPB45_0016 4c76024db9f03b0a89161c6bf83989f1 79 TIGRFAM TIGR00517 acyl_carrier: acyl carrier protein 2 75 5.5E-33 T 13-10-2018 IPR003231 Acyl carrier protein (ACP) GO:0006633 Reactome: R-HSA-389661|Reactome: R-HSA-611105|Reactome: R-HSA-6799198|Reactome: R-HSA-77289 TOPB45_0928 4e3b7301b6f5dd46e63fbafd0fb6821b 261 Gene3D G3DSA:3.40.50.10790 2 164 6.6E-55 T 13-10-2018 IPR023228 S-adenosyl-l-methionine hydroxide adenosyltransferase, N-terminal TOPB45_0928 4e3b7301b6f5dd46e63fbafd0fb6821b 261 Gene3D G3DSA:2.40.30.90 168 256 5.2E-21 T 13-10-2018 IPR023227 S-adenosyl-l-methionine hydroxide adenosyltransferase, C-terminal TOPB45_0928 4e3b7301b6f5dd46e63fbafd0fb6821b 261 SUPERFAMILY SSF101852 174 247 3.01E-16 T 13-10-2018 IPR023227 S-adenosyl-l-methionine hydroxide adenosyltransferase, C-terminal TOPB45_0928 4e3b7301b6f5dd46e63fbafd0fb6821b 261 PIRSF PIRSF006779 1 257 2.4E-76 T 13-10-2018 IPR002747 SAM-dependent chlorinase/fluorinase TOPB45_0928 4e3b7301b6f5dd46e63fbafd0fb6821b 261 SUPERFAMILY SSF102522 3 164 1.09E-51 T 13-10-2018 IPR023228 S-adenosyl-l-methionine hydroxide adenosyltransferase, N-terminal TOPB45_0928 4e3b7301b6f5dd46e63fbafd0fb6821b 261 Pfam PF01887 S-adenosyl-l-methionine hydroxide adenosyltransferase 5 248 2.8E-69 T 13-10-2018 IPR002747 SAM-dependent chlorinase/fluorinase TOPB45_0317 362af468b9a18540c18ed6d588f1887b 208 Pfam PF13483 Beta-lactamase superfamily domain 8 178 6.2E-30 T 13-10-2018 TOPB45_0317 362af468b9a18540c18ed6d588f1887b 208 Gene3D G3DSA:3.60.15.10 7 208 3.0E-54 T 13-10-2018 IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like TOPB45_0317 362af468b9a18540c18ed6d588f1887b 208 SUPERFAMILY SSF56281 8 197 3.66E-27 T 13-10-2018 IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like TOPB45_0317 362af468b9a18540c18ed6d588f1887b 208 SMART SM00849 13 178 0.0019 T 13-10-2018 IPR001279 Metallo-beta-lactamase TOPB45_0661 9edc5da2fb73453149f6670a227e4a55 187 Pfam PF00596 Class II Aldolase and Adducin N-terminal domain 6 178 1.0E-38 T 13-10-2018 IPR001303 Class II aldolase/adducin N-terminal TOPB45_0661 9edc5da2fb73453149f6670a227e4a55 187 SUPERFAMILY SSF53639 4 180 5.1E-44 T 13-10-2018 IPR036409 Class II aldolase/adducin N-terminal domain superfamily TOPB45_0661 9edc5da2fb73453149f6670a227e4a55 187 SMART SM01007 5 179 2.3E-39 T 13-10-2018 IPR001303 Class II aldolase/adducin N-terminal TOPB45_0661 9edc5da2fb73453149f6670a227e4a55 187 Gene3D G3DSA:3.40.225.10 2 187 8.1E-47 T 13-10-2018 IPR036409 Class II aldolase/adducin N-terminal domain superfamily TOPB45_0888 e5902cc752526d4eb86421b5b86a7aa7 113 SMART SM00418 8 86 8.4E-33 T 13-10-2018 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TOPB45_0888 e5902cc752526d4eb86421b5b86a7aa7 113 Pfam PF01022 Bacterial regulatory protein, arsR family 16 61 1.9E-17 T 13-10-2018 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TOPB45_0888 e5902cc752526d4eb86421b5b86a7aa7 113 Gene3D G3DSA:1.10.10.10 1 104 2.8E-30 T 13-10-2018 IPR036388 Winged helix-like DNA-binding domain superfamily TOPB45_0888 e5902cc752526d4eb86421b5b86a7aa7 113 SUPERFAMILY SSF46785 1 95 1.57E-28 T 13-10-2018 IPR036390 Winged helix DNA-binding domain superfamily TOPB45_0888 e5902cc752526d4eb86421b5b86a7aa7 113 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 10 25 4.0E-21 T 13-10-2018 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TOPB45_0888 e5902cc752526d4eb86421b5b86a7aa7 113 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 42 57 4.0E-21 T 13-10-2018 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TOPB45_0888 e5902cc752526d4eb86421b5b86a7aa7 113 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 57 72 4.0E-21 T 13-10-2018 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TOPB45_0888 e5902cc752526d4eb86421b5b86a7aa7 113 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 29 40 4.0E-21 T 13-10-2018 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 TOPB45_1394 942f7a348172ccf9f8898af4ca132cab 96 ProSitePatterns PS00681 Chaperonins cpn10 signature. 3 27 - T 13-10-2018 IPR018369 Chaperonin GroES, conserved site GO:0005524|GO:0006457 TOPB45_1394 942f7a348172ccf9f8898af4ca132cab 96 SUPERFAMILY SSF50129 1 95 1.51E-37 T 13-10-2018 IPR011032 GroES-like superfamily TOPB45_1394 942f7a348172ccf9f8898af4ca132cab 96 Gene3D G3DSA:2.30.33.40 1 96 2.3E-40 T 13-10-2018 IPR037124 GroES chaperonin superfamily GO:0005737|GO:0006457 TOPB45_1394 942f7a348172ccf9f8898af4ca132cab 96 Pfam PF00166 Chaperonin 10 Kd subunit 2 94 5.0E-38 T 13-10-2018 IPR020818 GroES chaperonin family GO:0005737|GO:0006457 TOPB45_1394 942f7a348172ccf9f8898af4ca132cab 96 SMART SM00883 2 94 6.4E-60 T 13-10-2018 IPR020818 GroES chaperonin family GO:0005737|GO:0006457 TOPB45_1394 942f7a348172ccf9f8898af4ca132cab 96 PRINTS PR00297 10kDa chaperonin signature 81 94 5.8E-34 T 13-10-2018 IPR020818 GroES chaperonin family GO:0005737|GO:0006457 TOPB45_1394 942f7a348172ccf9f8898af4ca132cab 96 PRINTS PR00297 10kDa chaperonin signature 3 18 5.8E-34 T 13-10-2018 IPR020818 GroES chaperonin family GO:0005737|GO:0006457 TOPB45_1394 942f7a348172ccf9f8898af4ca132cab 96 PRINTS PR00297 10kDa chaperonin signature 25 46 5.8E-34 T 13-10-2018 IPR020818 GroES chaperonin family GO:0005737|GO:0006457 TOPB45_1394 942f7a348172ccf9f8898af4ca132cab 96 PRINTS PR00297 10kDa chaperonin signature 60 72 5.8E-34 T 13-10-2018 IPR020818 GroES chaperonin family GO:0005737|GO:0006457 TOPB45_1394 942f7a348172ccf9f8898af4ca132cab 96 Hamap MF_00580 10 kDa chaperonin [groS]. 2 95 28.053 T 13-10-2018 IPR020818 GroES chaperonin family GO:0005737|GO:0006457 TOPB45_0367 20fb84f754395e5e1f32a6cd7d4385b4 343 Gene3D G3DSA:3.30.420.40 155 318 3.1E-134 T 13-10-2018 TOPB45_0367 20fb84f754395e5e1f32a6cd7d4385b4 343 Pfam PF06723 MreB/Mbl protein 10 336 1.1E-149 T 13-10-2018 IPR004753 Cell shape determining protein MreB GO:0000902 TOPB45_0367 20fb84f754395e5e1f32a6cd7d4385b4 343 SUPERFAMILY SSF53067 151 333 2.46E-50 T 13-10-2018 TOPB45_0367 20fb84f754395e5e1f32a6cd7d4385b4 343 SUPERFAMILY SSF53067 10 149 4.57E-40 T 13-10-2018 TOPB45_0367 20fb84f754395e5e1f32a6cd7d4385b4 343 TIGRFAM TIGR00904 mreB: cell shape determining protein, MreB/Mrl family 10 337 4.6E-157 T 13-10-2018 IPR004753 Cell shape determining protein MreB GO:0000902 TOPB45_0367 20fb84f754395e5e1f32a6cd7d4385b4 343 PRINTS PR01652 Bacterial cell shape determinant MreB/Mbl protein signature 70 93 2.5E-62 T 13-10-2018 IPR004753 Cell shape determining protein MreB GO:0000902 TOPB45_0367 20fb84f754395e5e1f32a6cd7d4385b4 343 PRINTS PR01652 Bacterial cell shape determinant MreB/Mbl protein signature 188 208 2.5E-62 T 13-10-2018 IPR004753 Cell shape determining protein MreB GO:0000902 TOPB45_0367 20fb84f754395e5e1f32a6cd7d4385b4 343 PRINTS PR01652 Bacterial cell shape determinant MreB/Mbl protein signature 50 68 2.5E-62 T 13-10-2018 IPR004753 Cell shape determining protein MreB GO:0000902 TOPB45_0367 20fb84f754395e5e1f32a6cd7d4385b4 343 PRINTS PR01652 Bacterial cell shape determinant MreB/Mbl protein signature 133 152 2.5E-62 T 13-10-2018 IPR004753 Cell shape determining protein MreB GO:0000902 TOPB45_0367 20fb84f754395e5e1f32a6cd7d4385b4 343 PRINTS PR01652 Bacterial cell shape determinant MreB/Mbl protein signature 301 327 2.5E-62 T 13-10-2018 IPR004753 Cell shape determining protein MreB GO:0000902 TOPB45_0367 20fb84f754395e5e1f32a6cd7d4385b4 343 Gene3D G3DSA:3.30.420.40 13 328 3.1E-134 T 13-10-2018 TOPB45_0367 20fb84f754395e5e1f32a6cd7d4385b4 343 Gene3D G3DSA:3.90.640.10 187 260 3.1E-134 T 13-10-2018 TOPB45_1148 fa1c11e9178bbf4c8ad08880e19d7b1b 245 TIGRFAM TIGR00726 TIGR00726: YfiH family protein 50 241 1.2E-46 T 13-10-2018 IPR003730 Multi-copper polyphenol oxidoreductase TOPB45_1148 fa1c11e9178bbf4c8ad08880e19d7b1b 245 SUPERFAMILY SSF64438 47 242 1.43E-48 T 13-10-2018 IPR011324 Cytotoxic necrotizing factor-like, catalytic TOPB45_1148 fa1c11e9178bbf4c8ad08880e19d7b1b 245 Gene3D G3DSA:3.60.140.10 40 244 1.2E-51 T 13-10-2018 IPR038371 Multi-copper polyphenol oxidoreductase superfamily TOPB45_1148 fa1c11e9178bbf4c8ad08880e19d7b1b 245 Pfam PF02578 Multi-copper polyphenol oxidoreductase laccase 42 231 2.6E-43 T 13-10-2018 IPR003730 Multi-copper polyphenol oxidoreductase TOPB45_0625 f27157bcacb8dd0553339400ada2b6e5 313 Pfam PF01384 Phosphate transporter family 16 302 4.6E-58 T 13-10-2018 IPR001204 Phosphate transporter GO:0005315|GO:0006817|GO:0016020 Reactome: R-HSA-427652 TOPB45_0242 f84ec77b9e6b421200ef2c614afd81d9 154 Gene3D G3DSA:3.10.50.40 2 153 1.9E-39 T 13-10-2018 TOPB45_0242 f84ec77b9e6b421200ef2c614afd81d9 154 SUPERFAMILY SSF54534 3 145 1.96E-37 T 13-10-2018 TOPB45_0242 f84ec77b9e6b421200ef2c614afd81d9 154 Pfam PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 3 141 1.2E-18 T 13-10-2018 IPR001179 FKBP-type peptidyl-prolyl cis-trans isomerase domain TOPB45_0030 e2d1a9690e76a97c172d77388938fad8 269 TIGRFAM TIGR01852 lipid_A_lpxA: acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase 4 257 3.3E-95 T 13-10-2018 IPR010137 Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase GO:0008610|GO:0008780 KEGG: 00540+2.3.1.129 TOPB45_0030 e2d1a9690e76a97c172d77388938fad8 269 Pfam PF00132 Bacterial transferase hexapeptide (six repeats) 13 47 5.7E-9 T 13-10-2018 IPR001451 Hexapeptide repeat TOPB45_0030 e2d1a9690e76a97c172d77388938fad8 269 Pfam PF00132 Bacterial transferase hexapeptide (six repeats) 105 139 4.7E-11 T 13-10-2018 IPR001451 Hexapeptide repeat TOPB45_0030 e2d1a9690e76a97c172d77388938fad8 269 Gene3D G3DSA:2.160.10.10 1 191 5.5E-60 T 13-10-2018 TOPB45_0030 e2d1a9690e76a97c172d77388938fad8 269 Hamap MF_00387 Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase [lpxA]. 1 259 41.193 T 13-10-2018 IPR010137 Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase GO:0008610|GO:0008780 KEGG: 00540+2.3.1.129 TOPB45_0030 e2d1a9690e76a97c172d77388938fad8 269 SUPERFAMILY SSF51161 3 253 1.98E-77 T 13-10-2018 IPR011004 Trimeric LpxA-like superfamily TOPB45_0030 e2d1a9690e76a97c172d77388938fad8 269 PIRSF PIRSF000456 1 267 6.7E-102 T 13-10-2018 IPR010137 Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase GO:0008610|GO:0008780 KEGG: 00540+2.3.1.129 TOPB45_0030 e2d1a9690e76a97c172d77388938fad8 269 Pfam PF13720 Udp N-acetylglucosamine O-acyltransferase; Domain 2 176 258 9.8E-18 T 13-10-2018 IPR029098 UDP N-acetylglucosamine O-acyltransferase, C-terminal KEGG: 00540+2.3.1.129 TOPB45_0030 e2d1a9690e76a97c172d77388938fad8 269 Gene3D G3DSA:1.20.1180.10 194 265 6.4E-12 T 13-10-2018 IPR037157 UDP-N-acetylglucosamine O-acyltransferase, C-terminal domain superfamily KEGG: 00540+2.3.1.129 TOPB45_0017 d35b1aa09125cb11d6e81fb1b0db990e 353 Pfam PF03739 Predicted permease YjgP/YjgQ family 6 347 4.8E-31 T 13-10-2018 IPR005495 Permease LptG/LptF-related GO:0016021 TOPB45_0383 62181668ae31830249b94ad4b55c41cb 186 Gene3D G3DSA:1.20.120.520 2 180 7.3E-35 T 13-10-2018 TOPB45_0383 62181668ae31830249b94ad4b55c41cb 186 Pfam PF01814 Hemerythrin HHE cation binding domain 4 137 9.9E-20 T 13-10-2018 IPR012312 Haemerythrin-like Reactome: R-HSA-390471|Reactome: R-HSA-8951664|Reactome: R-HSA-917937|Reactome: R-HSA-983168 TOPB45_1505 f0b3c5a20428f1388d28d3f49451f40d 196 SMART SM00851 16 130 1.2E-50 T 13-10-2018 IPR011607 Methylglyoxal synthase-like domain TOPB45_1505 f0b3c5a20428f1388d28d3f49451f40d 196 Gene3D G3DSA:3.40.50.1380 1 195 4.5E-87 T 13-10-2018 IPR036914 Methylglyoxal synthase-like domain superfamily TOPB45_1505 f0b3c5a20428f1388d28d3f49451f40d 196 Pfam PF01808 AICARFT/IMPCHase bienzyme 136 192 3.9E-17 T 13-10-2018 IPR002695 Bifunctional purine biosynthesis protein PurH-like GO:0003937|GO:0004643|GO:0006164 KEGG: 00230+3.5.4.10+2.1.2.3|KEGG: 00670+2.1.2.3|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234|Reactome: R-HSA-73817 TOPB45_1505 f0b3c5a20428f1388d28d3f49451f40d 196 SUPERFAMILY SSF52335 4 193 5.63E-66 T 13-10-2018 IPR036914 Methylglyoxal synthase-like domain superfamily TOPB45_1505 f0b3c5a20428f1388d28d3f49451f40d 196 Pfam PF02142 MGS-like domain 16 130 2.5E-28 T 13-10-2018 IPR011607 Methylglyoxal synthase-like domain TOPB45_0127 83a3066c3c7b8ee0821b1961220f6b2c 437 SUPERFAMILY SSF111283 14 436 4.97E-71 T 13-10-2018 IPR036059 Metalloprotease TldD/PmbA superfamily GO:0006508|GO:0008237 TOPB45_0127 83a3066c3c7b8ee0821b1961220f6b2c 437 Pfam PF01523 Putative modulator of DNA gyrase 42 299 4.6E-35 T 13-10-2018 IPR002510 Metalloprotease TldD/PmbA GO:0006508|GO:0008237 TOPB45_0127 83a3066c3c7b8ee0821b1961220f6b2c 437 Gene3D G3DSA:3.30.2290.10 2 205 2.0E-10 T 13-10-2018 IPR035068 Metalloprotease TldD/PmbA, N-terminal TOPB45_0899 fdf7f82cf9154ff2c3a5e6f6a1d5b114 183 Pfam PF03625 Domain of unknown function DUF302 92 149 9.6E-6 T 13-10-2018 IPR005180 Domain of unknown function DUF302 TOPB45_0899 fdf7f82cf9154ff2c3a5e6f6a1d5b114 183 Gene3D G3DSA:3.30.310.70 56 182 9.0E-10 T 13-10-2018 IPR035923 TT1751-like domain superfamily TOPB45_0899 fdf7f82cf9154ff2c3a5e6f6a1d5b114 183 SUPERFAMILY SSF103247 55 181 5.23E-18 T 13-10-2018 IPR035923 TT1751-like domain superfamily TOPB45_0508 89758fe324a0c8a4de7716761660c03e 245 Pfam PF06293 Lipopolysaccharide kinase (Kdo/WaaP) family 69 193 1.1E-11 T 13-10-2018 TOPB45_0508 89758fe324a0c8a4de7716761660c03e 245 SUPERFAMILY SSF56112 49 213 1.49E-15 T 13-10-2018 IPR011009 Protein kinase-like domain superfamily TOPB45_0508 89758fe324a0c8a4de7716761660c03e 245 Gene3D G3DSA:1.10.510.10 105 185 3.7E-6 T 13-10-2018 TOPB45_1040 3383195bb0f71e32836a3ec97a523e7e 217 TIGRFAM TIGR03879 near_KaiC_dom: probable regulatory domain 28 127 1.5E-36 T 13-10-2018 IPR022285 Conserved hypothetical protein CHP03879, regulatory domain, putative TOPB45_1327 aed99aa531e1e0a05e2d76fb6a3b947d 263 PIRSF PIRSF003092 1 262 3.4E-74 T 13-10-2018 IPR025501 ATP binding protein MinD TOPB45_1327 aed99aa531e1e0a05e2d76fb6a3b947d 263 Pfam PF13614 AAA domain 1 156 9.0E-22 T 13-10-2018 IPR025669 AAA domain TOPB45_1327 aed99aa531e1e0a05e2d76fb6a3b947d 263 SUPERFAMILY SSF52540 1 244 4.6E-44 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1327 aed99aa531e1e0a05e2d76fb6a3b947d 263 Gene3D G3DSA:3.40.50.300 2 242 2.8E-50 T 13-10-2018 TOPB45_0358 f7e30009f92c4286cd01a7cbc70918f7 76 Pfam PF10047 Protein of unknown function (DUF2281) 8 70 5.9E-18 T 13-10-2018 IPR018739 Domain of unknown function DUF2281 TOPB45_0914 76e956adcbeb086a2ec81d2be5ae443f 301 Gene3D G3DSA:3.40.50.10610 38 126 2.1E-36 T 13-10-2018 TOPB45_0914 76e956adcbeb086a2ec81d2be5ae443f 301 Gene3D G3DSA:3.40.50.10610 127 286 7.0E-52 T 13-10-2018 TOPB45_0914 76e956adcbeb086a2ec81d2be5ae443f 301 Pfam PF03783 Curli production assembly/transport component CsgG 48 266 3.3E-65 T 13-10-2018 IPR005534 Curli production assembly/transport component CsgG GO:0030288 TOPB45_1190 4de6121744b07b239c6114c2dab65168 66 SUPERFAMILY SSF158997 8 61 6.8E-16 T 13-10-2018 TOPB45_1190 4de6121744b07b239c6114c2dab65168 66 Pfam PF03966 Trm112p-like protein 10 46 6.2E-5 T 13-10-2018 IPR005651 Trm112-like TOPB45_1190 4de6121744b07b239c6114c2dab65168 66 Gene3D G3DSA:2.20.25.10 12 66 4.5E-18 T 13-10-2018 TOPB45_0953 a830ba353c91bed2d91caf78ef5b8e51 95 Pfam PF06305 Lipopolysaccharide assembly protein A domain 27 87 2.5E-11 T 13-10-2018 IPR010445 Lipopolysaccharide assembly protein A domain GO:0005887 TOPB45_0436 4e42f75b1547e4f765df549983ce4fe2 156 Gene3D G3DSA:3.40.1280.10 1 156 2.5E-43 T 13-10-2018 IPR029026 tRNA (guanine-N1-)-methyltransferase, N-terminal TOPB45_0436 4e42f75b1547e4f765df549983ce4fe2 156 Hamap MF_00658 Ribosomal RNA large subunit methyltransferase H [rlmH]. 3 155 23.381 T 13-10-2018 IPR003742 RNA methyltransferase RlmH GO:0005737|GO:0006364|GO:0008168 TOPB45_0436 4e42f75b1547e4f765df549983ce4fe2 156 SUPERFAMILY SSF75217 4 154 1.73E-37 T 13-10-2018 IPR029028 Alpha/beta knot methyltransferases TOPB45_0436 4e42f75b1547e4f765df549983ce4fe2 156 PIRSF PIRSF004505 3 155 1.4E-42 T 13-10-2018 IPR003742 RNA methyltransferase RlmH GO:0005737|GO:0006364|GO:0008168 TOPB45_0436 4e42f75b1547e4f765df549983ce4fe2 156 Pfam PF02590 Predicted SPOUT methyltransferase 4 154 1.0E-40 T 13-10-2018 IPR003742 RNA methyltransferase RlmH GO:0005737|GO:0006364|GO:0008168 TOPB45_0479 8add675cf797a33c186c67dff79e3f8a 432 ProSitePatterns PS00093 N-4 cytosine-specific DNA methylases signature. 270 275 - T 13-10-2018 IPR017985 DNA methylase, N-4 cytosine-specific, conserved site GO:0003677|GO:0015667|GO:0090124 TOPB45_0479 8add675cf797a33c186c67dff79e3f8a 432 Gene3D G3DSA:3.40.50.150 1 135 8.3E-10 T 13-10-2018 TOPB45_0479 8add675cf797a33c186c67dff79e3f8a 432 SUPERFAMILY SSF53335 41 114 1.43E-10 T 13-10-2018 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TOPB45_1341 eebfff54ef6cc734bf278424d8ea8c87 245 Gene3D G3DSA:1.20.1540.10 9 232 4.6E-33 T 13-10-2018 IPR035952 Rhomboid-like superfamily TOPB45_1341 eebfff54ef6cc734bf278424d8ea8c87 245 Pfam PF01694 Rhomboid family 68 225 9.3E-41 T 13-10-2018 IPR022764 Peptidase S54, rhomboid domain GO:0004252|GO:0016021 TOPB45_1341 eebfff54ef6cc734bf278424d8ea8c87 245 SUPERFAMILY SSF144091 9 227 7.72E-45 T 13-10-2018 TOPB45_0221 f21b9b7a3fc58e5fa78daab79dd5497e 292 TIGRFAM TIGR01475 ubiA_other: putative 4-hydroxybenzoate polyprenyltransferase 7 285 4.6E-97 T 13-10-2018 IPR006371 4-hydroxybenzoate polyprenyltransferase-related TOPB45_0221 f21b9b7a3fc58e5fa78daab79dd5497e 292 Gene3D G3DSA:1.10.357.140 14 181 1.1E-40 T 13-10-2018 TOPB45_0221 f21b9b7a3fc58e5fa78daab79dd5497e 292 Pfam PF01040 UbiA prenyltransferase family 24 271 9.8E-45 T 13-10-2018 IPR000537 UbiA prenyltransferase family GO:0016021|GO:0016765 TOPB45_1227 908d0796ff7118f0043bfc8007131833 93 Pfam PF09827 CRISPR associated protein Cas2 1 74 5.3E-20 T 13-10-2018 IPR019199 Virulence-associated protein D / CRISPR associated protein Cas2 TOPB45_1227 908d0796ff7118f0043bfc8007131833 93 Gene3D G3DSA:3.30.70.240 1 71 2.7E-26 T 13-10-2018 TOPB45_1227 908d0796ff7118f0043bfc8007131833 93 TIGRFAM TIGR01573 cas2: CRISPR-associated endonuclease Cas2 1 75 2.5E-10 T 13-10-2018 IPR021127 CRISPR-associated endonuclease Cas2 GO:0004521|GO:0043571 TOPB45_1227 908d0796ff7118f0043bfc8007131833 93 Hamap MF_01471 CRISPR-associated endoribonuclease Cas2 [cas2]. 1 93 13.191 T 13-10-2018 IPR021127 CRISPR-associated endonuclease Cas2 GO:0004521|GO:0043571 TOPB45_1227 908d0796ff7118f0043bfc8007131833 93 SUPERFAMILY SSF143430 1 81 2.88E-21 T 13-10-2018 TOPB45_0923 ec3af19f0c16ece278d25b357dd9ff26 483 Gene3D G3DSA:3.55.50.30 7 124 2.5E-11 T 13-10-2018 TOPB45_0923 ec3af19f0c16ece278d25b357dd9ff26 483 PRINTS PR00811 Bacterial general secretion pathway protein D signature 240 250 3.3E-12 T 13-10-2018 IPR001775 GspD/PilQ family TOPB45_0923 ec3af19f0c16ece278d25b357dd9ff26 483 PRINTS PR00811 Bacterial general secretion pathway protein D signature 304 328 3.3E-12 T 13-10-2018 IPR001775 GspD/PilQ family TOPB45_0923 ec3af19f0c16ece278d25b357dd9ff26 483 PRINTS PR00811 Bacterial general secretion pathway protein D signature 448 466 3.3E-12 T 13-10-2018 IPR001775 GspD/PilQ family TOPB45_0923 ec3af19f0c16ece278d25b357dd9ff26 483 PRINTS PR00811 Bacterial general secretion pathway protein D signature 471 483 3.3E-12 T 13-10-2018 IPR001775 GspD/PilQ family TOPB45_0923 ec3af19f0c16ece278d25b357dd9ff26 483 Pfam PF00263 Bacterial type II and III secretion system protein 309 483 1.3E-31 T 13-10-2018 IPR004846 Type II/III secretion system GO:0009306 TOPB45_0923 ec3af19f0c16ece278d25b357dd9ff26 483 TIGRFAM TIGR02519 pilus_MshL: pilus (MSHA type) biogenesis protein MshL 205 483 2.4E-76 T 13-10-2018 IPR013358 Pilus biogenesis, MshL TOPB45_0581 76546419b466b93182e4aa7eaac878d8 313 TIGRFAM TIGR00254 GGDEF: diguanylate cyclase (GGDEF) domain 131 228 1.1E-14 T 13-10-2018 IPR000160 GGDEF domain TOPB45_0581 76546419b466b93182e4aa7eaac878d8 313 Pfam PF00990 Diguanylate cyclase, GGDEF domain 136 232 8.3E-14 T 13-10-2018 IPR000160 GGDEF domain TOPB45_0581 76546419b466b93182e4aa7eaac878d8 313 SUPERFAMILY SSF55073 137 305 1.57E-20 T 13-10-2018 IPR029787 Nucleotide cyclase TOPB45_0581 76546419b466b93182e4aa7eaac878d8 313 Gene3D G3DSA:3.30.70.270 120 307 3.1E-21 T 13-10-2018 TOPB45_0581 76546419b466b93182e4aa7eaac878d8 313 SMART SM00267 121 291 2.6E-7 T 13-10-2018 IPR000160 GGDEF domain TOPB45_0256 af27bfd3dd07abb5096684d91017d30e 208 SUPERFAMILY SSF53098 38 192 3.62E-25 T 13-10-2018 IPR012337 Ribonuclease H-like superfamily TOPB45_0256 af27bfd3dd07abb5096684d91017d30e 208 Gene3D G3DSA:3.30.420.10 38 202 3.7E-7 T 13-10-2018 IPR036397 Ribonuclease H superfamily GO:0003676 TOPB45_0256 af27bfd3dd07abb5096684d91017d30e 208 Pfam PF13482 RNase_H superfamily 39 187 4.0E-39 T 13-10-2018 IPR038720 YprB, ribonuclease H-like domain TOPB45_1031 ea38ed45e8f6afdc1662cc8cbc9bca0f 251 Gene3D G3DSA:1.10.10.970 4 72 7.6E-6 T 13-10-2018 TOPB45_1031 ea38ed45e8f6afdc1662cc8cbc9bca0f 251 SUPERFAMILY SSF56399 8 177 1.29E-5 T 13-10-2018 TOPB45_1199 cd27600a96b79b6a784d10698de6c2f0 190 Pfam PF14361 RsbT co-antagonist protein rsbRD N-terminal domain 13 114 3.6E-10 T 13-10-2018 IPR025751 RsbT co-antagonist protein RsbRD, N-terminal domain TOPB45_0112 73a97e0b51610ae6fdff436f12850f93 220 SUPERFAMILY SSF53448 1 204 2.6E-23 T 13-10-2018 IPR029044 Nucleotide-diphospho-sugar transferases TOPB45_0112 73a97e0b51610ae6fdff436f12850f93 220 Gene3D G3DSA:3.90.550.10 1 210 3.2E-35 T 13-10-2018 IPR029044 Nucleotide-diphospho-sugar transferases TOPB45_0112 73a97e0b51610ae6fdff436f12850f93 220 Pfam PF12804 MobA-like NTP transferase domain 6 170 3.0E-22 T 13-10-2018 IPR025877 MobA-like NTP transferase TOPB45_0112 73a97e0b51610ae6fdff436f12850f93 220 Hamap MF_00316 Molybdenum cofactor guanylyltransferase [mobA]. 1 207 20.641 T 13-10-2018 IPR013482 Molybdenum cofactor guanylyltransferase GO:0003824|GO:0006777 KEGG: 00790+2.7.7.77|MetaCyc: PWY-5964|MetaCyc: PWY-7639 TOPB45_0454 96091db7e275ac820b8ca8c39ae2d957 383 Pfam PF00465 Iron-containing alcohol dehydrogenase 9 356 6.4E-101 T 13-10-2018 IPR001670 Alcohol dehydrogenase, iron-type/glycerol dehydrogenase GldA GO:0016491|GO:0046872|GO:0055114 Reactome: R-HSA-880009 TOPB45_0454 96091db7e275ac820b8ca8c39ae2d957 383 Gene3D G3DSA:1.20.1090.10 186 382 8.1E-43 T 13-10-2018 TOPB45_0454 96091db7e275ac820b8ca8c39ae2d957 383 Gene3D G3DSA:3.40.50.1970 1 184 1.6E-55 T 13-10-2018 TOPB45_0454 96091db7e275ac820b8ca8c39ae2d957 383 SUPERFAMILY SSF56796 1 381 4.06E-107 T 13-10-2018 TOPB45_1332 ff41300483bd8fba0ebfacacd5b463bf 89 PIRSF PIRSF004669 1 89 1.8E-31 T 13-10-2018 IPR002191 Bacterial export protein family 3 GO:0009306|GO:0016020 TOPB45_1332 ff41300483bd8fba0ebfacacd5b463bf 89 TIGRFAM TIGR01402 fliQ: flagellar biosynthetic protein FliQ 1 87 2.9E-30 T 13-10-2018 IPR006305 Flagellar biosynthesis protein FliQ GO:0016021|GO:0044780 TOPB45_1332 ff41300483bd8fba0ebfacacd5b463bf 89 PRINTS PR00952 Type III secretion system inner membrane Q protein family signature 54 76 6.5E-23 T 13-10-2018 IPR002191 Bacterial export protein family 3 GO:0009306|GO:0016020 TOPB45_1332 ff41300483bd8fba0ebfacacd5b463bf 89 PRINTS PR00952 Type III secretion system inner membrane Q protein family signature 39 54 6.5E-23 T 13-10-2018 IPR002191 Bacterial export protein family 3 GO:0009306|GO:0016020 TOPB45_1332 ff41300483bd8fba0ebfacacd5b463bf 89 PRINTS PR00952 Type III secretion system inner membrane Q protein family signature 18 39 6.5E-23 T 13-10-2018 IPR002191 Bacterial export protein family 3 GO:0009306|GO:0016020 TOPB45_1332 ff41300483bd8fba0ebfacacd5b463bf 89 Pfam PF01313 Bacterial export proteins, family 3 6 77 7.3E-29 T 13-10-2018 IPR002191 Bacterial export protein family 3 GO:0009306|GO:0016020 TOPB45_0450 435ede9abcebbf3fe0222c9352778b5d 263 Gene3D G3DSA:3.20.20.70 4 263 9.0E-94 T 13-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 TOPB45_0450 435ede9abcebbf3fe0222c9352778b5d 263 Hamap MF_00131 Tryptophan synthase alpha chain [trpA]. 18 262 32.816 T 13-10-2018 IPR002028 Tryptophan synthase, alpha chain GO:0004834|GO:0006568 KEGG: 00260+4.2.1.20|KEGG: 00400+4.2.1.20 TOPB45_0450 435ede9abcebbf3fe0222c9352778b5d 263 SUPERFAMILY SSF51366 8 259 3.77E-78 T 13-10-2018 IPR011060 Ribulose-phosphate binding barrel GO:0003824 TOPB45_0450 435ede9abcebbf3fe0222c9352778b5d 263 Pfam PF00290 Tryptophan synthase alpha chain 14 260 7.2E-80 T 13-10-2018 IPR002028 Tryptophan synthase, alpha chain GO:0004834|GO:0006568 KEGG: 00260+4.2.1.20|KEGG: 00400+4.2.1.20 TOPB45_0450 435ede9abcebbf3fe0222c9352778b5d 263 ProSitePatterns PS00167 Tryptophan synthase alpha chain signature. 52 65 - T 13-10-2018 IPR018204 Tryptophan synthase, alpha chain, active site GO:0004834 KEGG: 00260+4.2.1.20|KEGG: 00400+4.2.1.20 TOPB45_0450 435ede9abcebbf3fe0222c9352778b5d 263 TIGRFAM TIGR00262 trpA: tryptophan synthase, alpha subunit 14 263 2.0E-80 T 13-10-2018 IPR002028 Tryptophan synthase, alpha chain GO:0004834|GO:0006568 KEGG: 00260+4.2.1.20|KEGG: 00400+4.2.1.20 TOPB45_0259 709491d1fba88d31443bc4fe6b3da72c 258 Pfam PF02565 Recombination protein O C terminal 83 207 1.4E-11 T 13-10-2018 IPR003717 Recombination protein O, RecO GO:0006281|GO:0006310 TOPB45_0259 709491d1fba88d31443bc4fe6b3da72c 258 Hamap MF_00201 DNA repair protein RecO [recO]. 1 248 20.404 T 13-10-2018 IPR003717 Recombination protein O, RecO GO:0006281|GO:0006310 TOPB45_0259 709491d1fba88d31443bc4fe6b3da72c 258 Pfam PF11967 Recombination protein O N terminal 1 75 5.4E-12 T 13-10-2018 IPR022572 DNA replication/recombination mediator RecO, N-terminal TOPB45_0259 709491d1fba88d31443bc4fe6b3da72c 258 TIGRFAM TIGR00613 reco: DNA repair protein RecO 5 246 2.4E-28 T 13-10-2018 IPR003717 Recombination protein O, RecO GO:0006281|GO:0006310 TOPB45_0259 709491d1fba88d31443bc4fe6b3da72c 258 SUPERFAMILY SSF50249 1 75 4.97E-10 T 13-10-2018 IPR012340 Nucleic acid-binding, OB-fold TOPB45_0259 709491d1fba88d31443bc4fe6b3da72c 258 SUPERFAMILY SSF57863 82 208 3.14E-15 T 13-10-2018 IPR037278 ARFGAP/RecO-like zinc finger TOPB45_0259 709491d1fba88d31443bc4fe6b3da72c 258 Gene3D G3DSA:2.40.50.140 2 79 8.1E-12 T 13-10-2018 TOPB45_0294 ea6a882cec7f9017596f8b228183e51c 573 PRINTS PR00662 Glucose-6-phosphate isomerase signature 88 107 6.8E-7 T 13-10-2018 IPR001672 Phosphoglucose isomerase (PGI) GO:0004347|GO:0006094|GO:0006096 KEGG: 00010+5.3.1.9|KEGG: 00030+5.3.1.9|KEGG: 00500+5.3.1.9|KEGG: 00520+5.3.1.9|MetaCyc: PWY-3801|MetaCyc: PWY-5054|MetaCyc: PWY-5384|MetaCyc: PWY-5514|MetaCyc: PWY-5659|MetaCyc: PWY-6142|MetaCyc: PWY-621|MetaCyc: PWY-622|MetaCyc: PWY-6981|MetaCyc: PWY-6992|MetaCyc: PWY-7238|MetaCyc: PWY-7347|MetaCyc: PWY-7385|Reactome: R-HSA-5628897|Reactome: R-HSA-6798695|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_0294 ea6a882cec7f9017596f8b228183e51c 573 PRINTS PR00662 Glucose-6-phosphate isomerase signature 272 293 6.8E-7 T 13-10-2018 IPR001672 Phosphoglucose isomerase (PGI) GO:0004347|GO:0006094|GO:0006096 KEGG: 00010+5.3.1.9|KEGG: 00030+5.3.1.9|KEGG: 00500+5.3.1.9|KEGG: 00520+5.3.1.9|MetaCyc: PWY-3801|MetaCyc: PWY-5054|MetaCyc: PWY-5384|MetaCyc: PWY-5514|MetaCyc: PWY-5659|MetaCyc: PWY-6142|MetaCyc: PWY-621|MetaCyc: PWY-622|MetaCyc: PWY-6981|MetaCyc: PWY-6992|MetaCyc: PWY-7238|MetaCyc: PWY-7347|MetaCyc: PWY-7385|Reactome: R-HSA-5628897|Reactome: R-HSA-6798695|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_0294 ea6a882cec7f9017596f8b228183e51c 573 PRINTS PR00662 Glucose-6-phosphate isomerase signature 197 215 6.8E-7 T 13-10-2018 IPR001672 Phosphoglucose isomerase (PGI) GO:0004347|GO:0006094|GO:0006096 KEGG: 00010+5.3.1.9|KEGG: 00030+5.3.1.9|KEGG: 00500+5.3.1.9|KEGG: 00520+5.3.1.9|MetaCyc: PWY-3801|MetaCyc: PWY-5054|MetaCyc: PWY-5384|MetaCyc: PWY-5514|MetaCyc: PWY-5659|MetaCyc: PWY-6142|MetaCyc: PWY-621|MetaCyc: PWY-622|MetaCyc: PWY-6981|MetaCyc: PWY-6992|MetaCyc: PWY-7238|MetaCyc: PWY-7347|MetaCyc: PWY-7385|Reactome: R-HSA-5628897|Reactome: R-HSA-6798695|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_0294 ea6a882cec7f9017596f8b228183e51c 573 Gene3D G3DSA:3.40.50.10490 53 222 3.3E-42 T 13-10-2018 TOPB45_0294 ea6a882cec7f9017596f8b228183e51c 573 SUPERFAMILY SSF53697 54 401 2.46E-72 T 13-10-2018 TOPB45_0294 ea6a882cec7f9017596f8b228183e51c 573 Gene3D G3DSA:3.40.50.10490 223 315 3.5E-5 T 13-10-2018 TOPB45_0294 ea6a882cec7f9017596f8b228183e51c 573 Pfam PF00342 Phosphoglucose isomerase 83 296 6.8E-16 T 13-10-2018 IPR001672 Phosphoglucose isomerase (PGI) GO:0004347|GO:0006094|GO:0006096 KEGG: 00010+5.3.1.9|KEGG: 00030+5.3.1.9|KEGG: 00500+5.3.1.9|KEGG: 00520+5.3.1.9|MetaCyc: PWY-3801|MetaCyc: PWY-5054|MetaCyc: PWY-5384|MetaCyc: PWY-5514|MetaCyc: PWY-5659|MetaCyc: PWY-6142|MetaCyc: PWY-621|MetaCyc: PWY-622|MetaCyc: PWY-6981|MetaCyc: PWY-6992|MetaCyc: PWY-7238|MetaCyc: PWY-7347|MetaCyc: PWY-7385|Reactome: R-HSA-5628897|Reactome: R-HSA-6798695|Reactome: R-HSA-70171|Reactome: R-HSA-70263 TOPB45_0320 a2b89febeb68745ba09e7a03b0eab8b0 160 Gene3D G3DSA:3.90.20.10 81 152 1.5E-13 T 13-10-2018 TOPB45_0958 9115847153ebdd5e0fce95870d978159 238 Pfam PF03692 Putative zinc- or iron-chelating domain 22 119 3.9E-10 T 13-10-2018 IPR005358 Putative zinc- or iron-chelating domain containing protein TOPB45_0353 a420e7aa0988b5d4380a3aeb8f4c593b 75 Pfam PF07927 HicA toxin of bacterial toxin-antitoxin, 10 66 2.5E-20 T 13-10-2018 IPR012933 HicA mRNA interferase family GO:0003729 TOPB45_0353 a420e7aa0988b5d4380a3aeb8f4c593b 75 Gene3D G3DSA:3.30.920.30 4 73 5.5E-21 T 13-10-2018 IPR038570 HicA superfamily TOPB45_0353 a420e7aa0988b5d4380a3aeb8f4c593b 75 SUPERFAMILY SSF54786 5 73 3.49E-19 T 13-10-2018 TOPB45_1361 988eb9eedad8458a22f60197d1158b48 477 Pfam PF03961 Flagellar Assembly Protein A 18 470 1.4E-79 T 13-10-2018 IPR005646 Flagellar assembly protein A TOPB45_0417 916fa89114310ef81b4c1a11995c69ec 357 Gene3D G3DSA:3.90.10.10 173 222 2.4E-5 T 13-10-2018 TOPB45_0417 916fa89114310ef81b4c1a11995c69ec 357 SUPERFAMILY SSF48695 73 300 2.98E-17 T 13-10-2018 IPR036280 Multiheme cytochrome superfamily TOPB45_0410 e71f9294d33fc97d4783c2191c7ef7ab 156 SUPERFAMILY SSF52540 18 129 3.73E-18 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0410 e71f9294d33fc97d4783c2191c7ef7ab 156 Pfam PF02367 Threonylcarbamoyl adenosine biosynthesis protein TsaE 8 125 3.6E-34 T 13-10-2018 IPR003442 tRNA threonylcarbamoyl adenosine modification protein TsaE GO:0002949 TOPB45_0410 e71f9294d33fc97d4783c2191c7ef7ab 156 TIGRFAM TIGR00150 T6A_YjeE: tRNA threonylcarbamoyl adenosine modification protein YjeE 9 137 4.3E-32 T 13-10-2018 IPR003442 tRNA threonylcarbamoyl adenosine modification protein TsaE GO:0002949 TOPB45_0410 e71f9294d33fc97d4783c2191c7ef7ab 156 Gene3D G3DSA:3.40.50.300 2 149 3.3E-37 T 13-10-2018 TOPB45_1068 4f2235a33329218d5a8f13af3174eb6a 404 Pfam PF12704 MacB-like periplasmic core domain 24 243 5.3E-22 T 13-10-2018 IPR025857 MacB-like periplasmic core domain TOPB45_0169 9a3f782374905930acd1c00c18a290a1 174 Pfam PF02357 Transcription termination factor nusG 4 104 1.6E-8 T 13-10-2018 IPR006645 NusG, N-terminal GO:0006355 Reactome: R-HSA-112382|Reactome: R-HSA-113418|Reactome: R-HSA-167152|Reactome: R-HSA-167158|Reactome: R-HSA-167160|Reactome: R-HSA-167200|Reactome: R-HSA-167238|Reactome: R-HSA-167242|Reactome: R-HSA-167243|Reactome: R-HSA-167246|Reactome: R-HSA-167287|Reactome: R-HSA-167290|Reactome: R-HSA-674695|Reactome: R-HSA-6796648|Reactome: R-HSA-6807505|Reactome: R-HSA-72086|Reactome: R-HSA-75955|Reactome: R-HSA-77075 TOPB45_0169 9a3f782374905930acd1c00c18a290a1 174 SMART SM00739 120 147 4.0E-5 T 13-10-2018 IPR005824 KOW TOPB45_0169 9a3f782374905930acd1c00c18a290a1 174 Pfam PF00467 KOW motif 124 155 2.4E-7 T 13-10-2018 IPR005824 KOW TOPB45_0169 9a3f782374905930acd1c00c18a290a1 174 SUPERFAMILY SSF82679 5 107 1.7E-12 T 13-10-2018 IPR036735 NusG, N-terminal domain superfamily GO:0006355 Reactome: R-HSA-112382|Reactome: R-HSA-113418|Reactome: R-HSA-167152|Reactome: R-HSA-167158|Reactome: R-HSA-167160|Reactome: R-HSA-167200|Reactome: R-HSA-167238|Reactome: R-HSA-167242|Reactome: R-HSA-167243|Reactome: R-HSA-167246|Reactome: R-HSA-167287|Reactome: R-HSA-167290|Reactome: R-HSA-674695|Reactome: R-HSA-6796648|Reactome: R-HSA-6807505|Reactome: R-HSA-72086|Reactome: R-HSA-75955|Reactome: R-HSA-77075 TOPB45_0169 9a3f782374905930acd1c00c18a290a1 174 Gene3D G3DSA:2.30.30.30 116 174 3.5E-26 T 13-10-2018 IPR014722 Ribosomal protein L2, domain 2 TOPB45_0169 9a3f782374905930acd1c00c18a290a1 174 TIGRFAM TIGR00922 nusG: transcription termination/antitermination factor NusG 5 174 8.6E-43 T 13-10-2018 IPR001062 Transcription antitermination protein, NusG GO:0032784 TOPB45_0169 9a3f782374905930acd1c00c18a290a1 174 ProSitePatterns PS01014 Transcription termination factor nusG signature. 157 166 - T 13-10-2018 IPR015869 Transcription antitermination protein, NusG, bacteria, conserved site TOPB45_0169 9a3f782374905930acd1c00c18a290a1 174 SUPERFAMILY SSF50104 119 174 4.73E-18 T 13-10-2018 IPR008991 Translation protein SH3-like domain superfamily TOPB45_0169 9a3f782374905930acd1c00c18a290a1 174 Gene3D G3DSA:3.30.70.940 1 115 1.8E-15 T 13-10-2018 IPR036735 NusG, N-terminal domain superfamily GO:0006355 Reactome: R-HSA-112382|Reactome: R-HSA-113418|Reactome: R-HSA-167152|Reactome: R-HSA-167158|Reactome: R-HSA-167160|Reactome: R-HSA-167200|Reactome: R-HSA-167238|Reactome: R-HSA-167242|Reactome: R-HSA-167243|Reactome: R-HSA-167246|Reactome: R-HSA-167287|Reactome: R-HSA-167290|Reactome: R-HSA-674695|Reactome: R-HSA-6796648|Reactome: R-HSA-6807505|Reactome: R-HSA-72086|Reactome: R-HSA-75955|Reactome: R-HSA-77075 TOPB45_0169 9a3f782374905930acd1c00c18a290a1 174 PRINTS PR00338 Transcription termination factor NUSG signature 132 147 2.0E-15 T 13-10-2018 IPR001062 Transcription antitermination protein, NusG GO:0032784 TOPB45_0169 9a3f782374905930acd1c00c18a290a1 174 PRINTS PR00338 Transcription termination factor NUSG signature 150 166 2.0E-15 T 13-10-2018 IPR001062 Transcription antitermination protein, NusG GO:0032784 TOPB45_0169 9a3f782374905930acd1c00c18a290a1 174 PRINTS PR00338 Transcription termination factor NUSG signature 56 68 2.0E-15 T 13-10-2018 IPR001062 Transcription antitermination protein, NusG GO:0032784 TOPB45_0011 13f16231da24e68d5d60ffbef790cd9e 134 Gene3D G3DSA:2.40.10.220 2 92 4.4E-6 T 13-10-2018 TOPB45_0011 13f16231da24e68d5d60ffbef790cd9e 134 SUPERFAMILY SSF141371 1 87 3.02E-6 T 13-10-2018 TOPB45_0011 13f16231da24e68d5d60ffbef790cd9e 134 Pfam PF07238 PilZ domain 4 89 4.8E-8 T 13-10-2018 IPR009875 PilZ domain GO:0035438 TOPB45_0381 3cbc40f0bef19f0511a39e9ad3c3748a 245 Pfam PF12837 4Fe-4S binding domain 8 31 1.9E-7 T 13-10-2018 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain TOPB45_0381 3cbc40f0bef19f0511a39e9ad3c3748a 245 SUPERFAMILY SSF54862 6 69 1.05E-15 T 13-10-2018 TOPB45_0381 3cbc40f0bef19f0511a39e9ad3c3748a 245 Gene3D G3DSA:3.30.70.20 6 69 3.2E-11 T 13-10-2018 TOPB45_1147 190dd7f2b41a177295d3e168a1336017 416 Pfam PF04413 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) 49 210 6.1E-58 T 13-10-2018 IPR007507 3-deoxy-D-manno-octulosonic-acid transferase, N-terminal KEGG: 00540+2.4.99.12|MetaCyc: PWY-7675 TOPB45_1147 190dd7f2b41a177295d3e168a1336017 416 Gene3D G3DSA:3.40.50.11720 33 208 3.4E-50 T 13-10-2018 IPR038107 3-deoxy-D-manno-octulosonic-acid transferase, N-terminal domain superfamily KEGG: 00540+2.4.99.12|MetaCyc: PWY-7675 TOPB45_1147 190dd7f2b41a177295d3e168a1336017 416 SUPERFAMILY SSF53756 51 415 3.77E-16 T 13-10-2018 TOPB45_1147 190dd7f2b41a177295d3e168a1336017 416 Pfam PF00534 Glycosyl transferases group 1 309 395 7.2E-7 T 13-10-2018 IPR001296 Glycosyl transferase, family 1 TOPB45_1147 190dd7f2b41a177295d3e168a1336017 416 Gene3D G3DSA:3.40.50.2000 218 399 2.3E-45 T 13-10-2018 TOPB45_0852 98a506ccf5e4a859e2aa507b102e94ca 126 Pfam PF02472 Biopolymer transport protein ExbD/TolR 7 123 1.7E-22 T 13-10-2018 IPR003400 Biopolymer transport protein ExbD/TolR GO:0022857|GO:0055085 TOPB45_0852 98a506ccf5e4a859e2aa507b102e94ca 126 Gene3D G3DSA:3.30.420.270 55 119 1.9E-6 T 13-10-2018 TOPB45_0065 06c874048e0921d7f26c1afcafb6866d 186 Gene3D G3DSA:1.25.60.10 86 185 8.6E-7 T 13-10-2018 IPR038076 MgtE, N-terminal domain superfamily TOPB45_0065 06c874048e0921d7f26c1afcafb6866d 186 SUPERFAMILY SSF158791 117 178 7.98E-9 T 13-10-2018 TOPB45_0065 06c874048e0921d7f26c1afcafb6866d 186 Pfam PF03448 MgtE intracellular N domain 119 178 1.7E-8 T 13-10-2018 IPR006668 Magnesium transporter, MgtE intracellular domain TOPB45_1259 7e33d6ce3f8359958838219e7f910a34 222 Gene3D G3DSA:3.40.50.880 1 219 1.7E-55 T 13-10-2018 IPR029062 Class I glutamine amidotransferase-like TOPB45_1259 7e33d6ce3f8359958838219e7f910a34 222 Pfam PF00117 Glutamine amidotransferase class-I 28 182 7.6E-14 T 13-10-2018 IPR017926 Glutamine amidotransferase TOPB45_1259 7e33d6ce3f8359958838219e7f910a34 222 SUPERFAMILY SSF52317 19 194 5.03E-43 T 13-10-2018 IPR029062 Class I glutamine amidotransferase-like TOPB45_0345 a3e4b418745b5f08f429de77f81d00be 337 SUPERFAMILY SSF53448 3 325 2.0E-33 T 13-10-2018 IPR029044 Nucleotide-diphospho-sugar transferases TOPB45_0345 a3e4b418745b5f08f429de77f81d00be 337 Pfam PF00535 Glycosyl transferase family 2 7 114 1.5E-16 T 13-10-2018 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 TOPB45_0345 a3e4b418745b5f08f429de77f81d00be 337 Gene3D G3DSA:3.90.550.10 1 261 1.7E-28 T 13-10-2018 IPR029044 Nucleotide-diphospho-sugar transferases TOPB45_0429 b77364a64453cc97189748ffe55a13f8 394 Gene3D G3DSA:3.40.50.12170 15 222 1.5E-109 T 13-10-2018 TOPB45_0429 b77364a64453cc97189748ffe55a13f8 394 Pfam PF07075 Protein of unknown function (DUF1343) 28 394 7.0E-115 T 13-10-2018 IPR008302 Uncharacterised conserved protein UCP016719 TOPB45_0429 b77364a64453cc97189748ffe55a13f8 394 Gene3D G3DSA:3.90.1150.140 223 372 1.5E-109 T 13-10-2018 TOPB45_0429 b77364a64453cc97189748ffe55a13f8 394 PIRSF PIRSF016719 1 394 4.7E-118 T 13-10-2018 IPR008302 Uncharacterised conserved protein UCP016719 TOPB45_0898 07b06985b4054ab6ef7c4e4bed5f3a43 445 SUPERFAMILY SSF56935 219 445 2.04E-5 T 13-10-2018 TOPB45_0898 07b06985b4054ab6ef7c4e4bed5f3a43 445 Pfam PF07396 Phosphate-selective porin O and P 62 418 6.0E-14 T 13-10-2018 IPR010870 Phosphate-selective porin O/P TOPB45_0898 07b06985b4054ab6ef7c4e4bed5f3a43 445 Gene3D G3DSA:2.40.160.10 52 429 5.8E-14 T 13-10-2018 IPR023614 Porin domain superfamily TOPB45_1112 2709b2d279bd47560cb6b74c33dd2984 321 TIGRFAM TIGR01903 cas5_csm4: CRISPR type III-A/MTUBE-associated RAMP protein Csm4 17 312 1.3E-26 T 13-10-2018 IPR005510 CRISPR type III-associated RAMP protein Csm4 TOPB45_1472 f16965626d5fc8237c7e2c92afe54810 284 SUPERFAMILY SSF53335 64 273 1.05E-28 T 13-10-2018 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TOPB45_1472 f16965626d5fc8237c7e2c92afe54810 284 Pfam PF06325 Ribosomal protein L11 methyltransferase (PrmA) 83 275 7.2E-29 T 13-10-2018 TOPB45_1472 f16965626d5fc8237c7e2c92afe54810 284 Gene3D G3DSA:3.40.50.150 97 282 7.6E-35 T 13-10-2018 TOPB45_0604 2cf8ea716f586447362f1488b74c6cd4 139 Pfam PF06146 Phosphate-starvation-inducible E 60 126 3.0E-12 T 13-10-2018 IPR020948 Phosphate-starvation-induced PsiE-like TOPB45_0946 4239ce5e39f8c824876119bcc461aa0f 243 Pfam PF08478 POTRA domain, FtsQ-type 39 104 6.4E-13 T 13-10-2018 IPR013685 POTRA domain, FtsQ-type TOPB45_0946 4239ce5e39f8c824876119bcc461aa0f 243 Pfam PF03799 Cell division protein FtsQ 110 214 3.1E-4 T 13-10-2018 IPR005548 Cell division protein FtsQ/DivIB TOPB45_0160 9d7bbea78c1efcfa85026d56f6a619c4 130 Pfam PF04519 Polymer-forming cytoskeletal 26 122 3.1E-22 T 13-10-2018 IPR007607 Bactofilin A/B TOPB45_0654 bb2accde441101394da43d82d48b171e 360 Gene3D G3DSA:1.10.8.1150 42 117 2.8E-15 T 13-10-2018 TOPB45_0654 bb2accde441101394da43d82d48b171e 360 Gene3D G3DSA:3.30.160.60 306 342 2.4E-10 T 13-10-2018 TOPB45_0654 bb2accde441101394da43d82d48b171e 360 Hamap MF_02065 Endolytic murein transglycosylase [mltG]. 11 336 33.891 T 13-10-2018 IPR003770 Endolytic murein transglycosylase TOPB45_0654 bb2accde441101394da43d82d48b171e 360 TIGRFAM TIGR00247 TIGR00247: conserved hypothetical protein, YceG family 8 334 2.8E-76 T 13-10-2018 IPR003770 Endolytic murein transglycosylase TOPB45_0654 bb2accde441101394da43d82d48b171e 360 Pfam PF02618 YceG-like family 48 333 3.8E-86 T 13-10-2018 IPR003770 Endolytic murein transglycosylase TOPB45_0236 19195593467ccc03a668f5c8a6250cf0 373 SUPERFAMILY SSF53383 3 369 4.71E-97 T 13-10-2018 IPR015424 Pyridoxal phosphate-dependent transferase TOPB45_0236 19195593467ccc03a668f5c8a6250cf0 373 Gene3D G3DSA:3.90.1150.10 5 367 6.6E-141 T 13-10-2018 IPR015422 Pyridoxal phosphate-dependent transferase domain 1 GO:0003824 TOPB45_0236 19195593467ccc03a668f5c8a6250cf0 373 PIRSF PIRSF005572 2 373 6.1E-127 T 13-10-2018 IPR016454 Cysteine desulfurase KEGG: 00730+2.8.1.7|MetaCyc: PWY-7250 TOPB45_0236 19195593467ccc03a668f5c8a6250cf0 373 Gene3D G3DSA:3.40.640.10 16 255 6.6E-141 T 13-10-2018 IPR015421 Pyridoxal phosphate-dependent transferase, major domain GO:0003824 TOPB45_0236 19195593467ccc03a668f5c8a6250cf0 373 Pfam PF00266 Aminotransferase class-V 5 360 2.4E-80 T 13-10-2018 IPR000192 Aminotransferase class V domain TOPB45_1265 8fa0413e325f9ed2484f6dc745178659 141 SUPERFAMILY SSF52218 3 113 1.34E-8 T 13-10-2018 IPR029039 Flavoprotein-like superfamily TOPB45_1265 8fa0413e325f9ed2484f6dc745178659 141 Gene3D G3DSA:3.40.50.360 2 135 5.6E-6 T 13-10-2018 IPR029039 Flavoprotein-like superfamily TOPB45_1232 89c829ff9032b2e7f2cebe6947f45993 136 Pfam PF05168 HEPN domain 6 125 9.3E-28 T 13-10-2018 IPR007842 HEPN domain TOPB45_1232 89c829ff9032b2e7f2cebe6947f45993 136 SUPERFAMILY SSF81593 9 126 2.63E-22 T 13-10-2018 TOPB45_1232 89c829ff9032b2e7f2cebe6947f45993 136 Gene3D G3DSA:1.20.120.330 2 130 3.4E-32 T 13-10-2018 TOPB45_1232 89c829ff9032b2e7f2cebe6947f45993 136 SMART SM00748 10 120 3.5E-9 T 13-10-2018 IPR007842 HEPN domain TOPB45_0285 824f63acf07a15c7e5bf9e8c63628ce4 187 Pfam PF00156 Phosphoribosyl transferase domain 20 171 5.4E-19 T 13-10-2018 IPR000836 Phosphoribosyltransferase domain GO:0009116 TOPB45_0285 824f63acf07a15c7e5bf9e8c63628ce4 187 Gene3D G3DSA:3.40.50.2020 2 186 4.7E-52 T 13-10-2018 TOPB45_0285 824f63acf07a15c7e5bf9e8c63628ce4 187 SUPERFAMILY SSF53271 11 181 2.88E-37 T 13-10-2018 IPR029057 Phosphoribosyltransferase-like TOPB45_0285 824f63acf07a15c7e5bf9e8c63628ce4 187 Hamap MF_01219 Bifunctional protein PyrR [pyrR]. 11 185 28.519 T 13-10-2018 IPR023050 Bifunctional protein PyrR KEGG: 00240+2.4.2.9|MetaCyc: PWY-7183 TOPB45_0361 ba796967d2645e7fab2524aa90c8177f 201 Pfam PF02397 Bacterial sugar transferase 8 187 3.9E-67 T 13-10-2018 IPR003362 Bacterial sugar transferase TOPB45_1241 0b98eacabf0847e472c0a38c067e7c22 365 TIGRFAM TIGR04112 seleno_YedE: putative selenium metabolism protein, YedE family 14 357 3.0E-146 T 13-10-2018 IPR026366 Putative selenium metabolism protein, YedE family TOPB45_1241 0b98eacabf0847e472c0a38c067e7c22 365 Pfam PF04143 Sulphur transport 222 331 3.6E-11 T 13-10-2018 IPR007272 Sulphur transport domain TOPB45_0281 ead20ac0ebc57447a7da52ed64edbbe9 435 SUPERFAMILY SSF53756 1 429 1.45E-83 T 13-10-2018 TOPB45_0281 ead20ac0ebc57447a7da52ed64edbbe9 435 Pfam PF00534 Glycosyl transferases group 1 250 406 5.9E-31 T 13-10-2018 IPR001296 Glycosyl transferase, family 1 TOPB45_0281 ead20ac0ebc57447a7da52ed64edbbe9 435 Gene3D G3DSA:3.40.50.2000 252 429 2.9E-37 T 13-10-2018 TOPB45_0281 ead20ac0ebc57447a7da52ed64edbbe9 435 Gene3D G3DSA:3.40.50.2000 1 251 7.3E-41 T 13-10-2018 TOPB45_0281 ead20ac0ebc57447a7da52ed64edbbe9 435 Pfam PF13439 Glycosyltransferase Family 4 133 238 1.0E-20 T 13-10-2018 IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain Reactome: R-HSA-446193|Reactome: R-HSA-4549349 TOPB45_0848 f21184ed8832d3d7de72f51a187d0d56 173 Pfam PF13565 Homeodomain-like domain 75 154 1.9E-8 T 13-10-2018 TOPB45_0848 f21184ed8832d3d7de72f51a187d0d56 173 SUPERFAMILY SSF46689 50 155 8.96E-9 T 13-10-2018 IPR009057 Homeobox-like domain superfamily GO:0003677 TOPB45_0118 fecf37ae9ad1c74510e7def24e7cdb51 233 Pfam PF01618 MotA/TolQ/ExbB proton channel family 107 213 3.2E-35 T 13-10-2018 IPR002898 MotA/TolQ/ExbB proton channel TOPB45_0568 19d514731d9e7b0abebfa831c937c5c2 555 Gene3D G3DSA:1.10.287.950 215 356 9.0E-12 T 13-10-2018 TOPB45_0568 19d514731d9e7b0abebfa831c937c5c2 555 SUPERFAMILY SSF58104 250 427 5.89E-10 T 13-10-2018 TOPB45_0819 d6b26bea212a683f528c82126773eef9 264 SUPERFAMILY SSF69917 22 264 2.22E-38 T 13-10-2018 IPR020080 Outer membrane adhesin/peptidase omptin GO:0004190 TOPB45_0819 d6b26bea212a683f528c82126773eef9 264 Gene3D G3DSA:2.40.128.100 70 264 1.5E-6 T 13-10-2018 TOPB45_1422 a66dd85faff9e18f01c8612ae572eac3 280 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 99 110 - T 13-10-2018 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site TOPB45_1422 a66dd85faff9e18f01c8612ae572eac3 280 SUPERFAMILY SSF52540 1 263 2.19E-28 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1422 a66dd85faff9e18f01c8612ae572eac3 280 Gene3D G3DSA:3.30.70.20 63 112 1.0E-10 T 13-10-2018 TOPB45_1422 a66dd85faff9e18f01c8612ae572eac3 280 SUPERFAMILY SSF54862 47 117 4.99E-16 T 13-10-2018 TOPB45_1422 a66dd85faff9e18f01c8612ae572eac3 280 Pfam PF01656 CobQ/CobB/MinD/ParA nucleotide binding domain 3 256 7.0E-17 T 13-10-2018 IPR002586 CobQ/CobB/MinD/ParA nucleotide binding domain TOPB45_1422 a66dd85faff9e18f01c8612ae572eac3 280 Pfam PF13187 4Fe-4S dicluster domain 65 114 1.2E-6 T 13-10-2018 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain TOPB45_0274 7f0a5c2f3e4babe30b6a39a48edcbb3b 283 SUPERFAMILY SSF102114 19 205 1.02E-13 T 13-10-2018 TOPB45_0274 7f0a5c2f3e4babe30b6a39a48edcbb3b 283 SMART SM00729 19 225 9.0E-4 T 13-10-2018 IPR006638 Elp3/MiaB/NifB GO:0003824|GO:0051536 TOPB45_0274 7f0a5c2f3e4babe30b6a39a48edcbb3b 283 Gene3D G3DSA:3.80.30.30 52 256 1.2E-11 T 13-10-2018 TOPB45_0274 7f0a5c2f3e4babe30b6a39a48edcbb3b 283 Pfam PF04055 Radical SAM superfamily 24 187 3.9E-12 T 13-10-2018 IPR007197 Radical SAM GO:0003824|GO:0051536 TOPB45_1292 9f473aeb09f6ccc39237a1aafb3ecdb5 258 ProSitePatterns PS01137 TatD deoxyribonuclease family signature 1. 3 11 - T 13-10-2018 IPR018228 Deoxyribonuclease, TatD-related, conserved site GO:0016888 TOPB45_1292 9f473aeb09f6ccc39237a1aafb3ecdb5 258 SUPERFAMILY SSF51556 1 257 6.43E-79 T 13-10-2018 IPR032466 Metal-dependent hydrolase TOPB45_1292 9f473aeb09f6ccc39237a1aafb3ecdb5 258 TIGRFAM TIGR00010 TIGR00010: hydrolase, TatD family 3 255 4.4E-82 T 13-10-2018 IPR015991 Uncharacterised hydrolase TatD-type GO:0004536 TOPB45_1292 9f473aeb09f6ccc39237a1aafb3ecdb5 258 ProSitePatterns PS01091 TatD deoxyribonuclease family signature 3. 191 207 - T 13-10-2018 IPR018228 Deoxyribonuclease, TatD-related, conserved site GO:0016888 TOPB45_1292 9f473aeb09f6ccc39237a1aafb3ecdb5 258 PIRSF PIRSF005902 1 258 9.3E-81 T 13-10-2018 IPR001130 TatD family GO:0016788 TOPB45_1292 9f473aeb09f6ccc39237a1aafb3ecdb5 258 Gene3D G3DSA:3.20.20.140 1 257 8.9E-88 T 13-10-2018 TOPB45_1292 9f473aeb09f6ccc39237a1aafb3ecdb5 258 Pfam PF01026 TatD related DNase 4 255 4.0E-73 T 13-10-2018 IPR001130 TatD family GO:0016788 TOPB45_0959 deb97e71ca93a881a2bd3337256a08d4 519 Hamap MF_02078 Probable lipid II flippase MurJ [murJ]. 7 475 18.194 T 13-10-2018 IPR004268 Peptidoglycan biosynthesis protein MurJ TOPB45_0959 deb97e71ca93a881a2bd3337256a08d4 519 Pfam PF03023 MviN-like protein 32 470 2.4E-97 T 13-10-2018 IPR004268 Peptidoglycan biosynthesis protein MurJ TOPB45_0959 deb97e71ca93a881a2bd3337256a08d4 519 PIRSF PIRSF002869 2 513 1.4E-128 T 13-10-2018 IPR004268 Peptidoglycan biosynthesis protein MurJ TOPB45_0959 deb97e71ca93a881a2bd3337256a08d4 519 TIGRFAM TIGR01695 murJ_mviN: murein biosynthesis integral membrane protein MurJ 9 506 4.5E-113 T 13-10-2018 IPR004268 Peptidoglycan biosynthesis protein MurJ TOPB45_0959 deb97e71ca93a881a2bd3337256a08d4 519 PRINTS PR01806 Virulence factor MviN signature 267 293 1.1E-46 T 13-10-2018 IPR004268 Peptidoglycan biosynthesis protein MurJ TOPB45_0959 deb97e71ca93a881a2bd3337256a08d4 519 PRINTS PR01806 Virulence factor MviN signature 365 384 1.1E-46 T 13-10-2018 IPR004268 Peptidoglycan biosynthesis protein MurJ TOPB45_0959 deb97e71ca93a881a2bd3337256a08d4 519 PRINTS PR01806 Virulence factor MviN signature 37 56 1.1E-46 T 13-10-2018 IPR004268 Peptidoglycan biosynthesis protein MurJ TOPB45_0959 deb97e71ca93a881a2bd3337256a08d4 519 PRINTS PR01806 Virulence factor MviN signature 137 161 1.1E-46 T 13-10-2018 IPR004268 Peptidoglycan biosynthesis protein MurJ TOPB45_0959 deb97e71ca93a881a2bd3337256a08d4 519 PRINTS PR01806 Virulence factor MviN signature 161 182 1.1E-46 T 13-10-2018 IPR004268 Peptidoglycan biosynthesis protein MurJ TOPB45_0959 deb97e71ca93a881a2bd3337256a08d4 519 PRINTS PR01806 Virulence factor MviN signature 417 434 1.1E-46 T 13-10-2018 IPR004268 Peptidoglycan biosynthesis protein MurJ TOPB45_0959 deb97e71ca93a881a2bd3337256a08d4 519 PRINTS PR01806 Virulence factor MviN signature 56 72 1.1E-46 T 13-10-2018 IPR004268 Peptidoglycan biosynthesis protein MurJ TOPB45_0415 c1fd3f0495ac7ba2e624eadfb7ff7d42 260 Pfam PF00432 Prenyltransferase and squalene oxidase repeat 5 47 0.0061 T 13-10-2018 IPR001330 PFTB repeat GO:0003824 TOPB45_0415 c1fd3f0495ac7ba2e624eadfb7ff7d42 260 Pfam PF00432 Prenyltransferase and squalene oxidase repeat 177 186 4.5 T 13-10-2018 IPR001330 PFTB repeat GO:0003824 TOPB45_0415 c1fd3f0495ac7ba2e624eadfb7ff7d42 260 Pfam PF00432 Prenyltransferase and squalene oxidase repeat 216 248 1.4E-4 T 13-10-2018 IPR001330 PFTB repeat GO:0003824 TOPB45_0415 c1fd3f0495ac7ba2e624eadfb7ff7d42 260 SUPERFAMILY SSF48239 3 256 1.51E-22 T 13-10-2018 IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid TOPB45_0415 c1fd3f0495ac7ba2e624eadfb7ff7d42 260 Gene3D G3DSA:1.50.10.20 96 259 5.1E-15 T 13-10-2018 TOPB45_0415 c1fd3f0495ac7ba2e624eadfb7ff7d42 260 Gene3D G3DSA:1.50.10.20 1 73 6.0E-6 T 13-10-2018 TOPB45_0385 96fa701228265e82941b36576c204a42 182 Pfam PF06195 Protein of unknown function (DUF996) 32 165 6.2E-38 T 13-10-2018 IPR010397 Protein of unknown function DUF996 TOPB45_0501 95cd7ea7521de0348bbd2b704853c260 380 TIGRFAM TIGR00765 yihY_not_rbn: YihY family inner membrane protein 17 256 8.6E-35 T 13-10-2018 IPR017039 Virulence factor BrkB TOPB45_0501 95cd7ea7521de0348bbd2b704853c260 380 Pfam PF03631 Virulence factor BrkB 23 257 4.5E-41 T 13-10-2018 IPR017039 Virulence factor BrkB TOPB45_1426 94e7a7b06d3f312c27eaf1ba1d93b505 123 SUPERFAMILY SSF46785 3 117 5.56E-24 T 13-10-2018 IPR036390 Winged helix DNA-binding domain superfamily TOPB45_1426 94e7a7b06d3f312c27eaf1ba1d93b505 123 Gene3D G3DSA:1.10.10.10 1 123 7.2E-28 T 13-10-2018 IPR036388 Winged helix-like DNA-binding domain superfamily TOPB45_1426 94e7a7b06d3f312c27eaf1ba1d93b505 123 Pfam PF02082 Transcriptional regulator 4 69 7.4E-18 T 13-10-2018 IPR000944 Transcription regulator Rrf2-type TOPB45_1426 94e7a7b06d3f312c27eaf1ba1d93b505 123 TIGRFAM TIGR00738 rrf2_super: Rrf2 family protein 2 116 1.7E-26 T 13-10-2018 IPR000944 Transcription regulator Rrf2-type TOPB45_1225 2dfbdd46721e8869ca94e997ee686cf7 169 TIGRFAM TIGR00372 cas4: CRISPR-associated protein Cas4 9 167 1.0E-27 T 13-10-2018 IPR013343 CRISPR-associated protein Cas4 TOPB45_1225 2dfbdd46721e8869ca94e997ee686cf7 169 Gene3D G3DSA:3.90.320.10 7 169 2.4E-6 T 13-10-2018 IPR011604 Exonuclease, phage-type/RecB, C-terminal TOPB45_1225 2dfbdd46721e8869ca94e997ee686cf7 169 Pfam PF01930 Domain of unknown function DUF83 10 168 9.0E-52 T 13-10-2018 IPR022765 Dna2/Cas4, domain of unknown function DUF83 TOPB45_1316 71d657990c1e00e7654915114d221b9b 77 Gene3D G3DSA:3.30.70.920 3 74 1.2E-22 T 13-10-2018 TOPB45_1316 71d657990c1e00e7654915114d221b9b 77 Pfam PF01037 Lrp/AsnC ligand binding domain 7 77 3.6E-13 T 13-10-2018 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain TOPB45_1316 71d657990c1e00e7654915114d221b9b 77 SUPERFAMILY SSF54909 3 76 1.13E-15 T 13-10-2018 IPR011008 Dimeric alpha-beta barrel TOPB45_1307 09102265f0ec19417bb67e0f0b2e461f 122 Pfam PF14489 QueF-like protein 46 121 8.0E-30 T 13-10-2018 IPR029500 NADPH-dependent 7-cyano-7-deazaguanine reductase QueF GO:0008616|GO:0033739 KEGG: 00790+1.7.1.13|MetaCyc: PWY-6700 TOPB45_1307 09102265f0ec19417bb67e0f0b2e461f 122 TIGRFAM TIGR03139 QueF-II: 7-cyano-7-deazaguanine reductase 12 121 1.2E-47 T 13-10-2018 IPR016856 NADPH-dependent 7-cyano-7-deazaguanine reductase, QueF type 1 GO:0005737|GO:0008616|GO:0046857|GO:0055114 KEGG: 00790+1.7.1.13|MetaCyc: PWY-6700 TOPB45_1307 09102265f0ec19417bb67e0f0b2e461f 122 Hamap MF_00818 NADPH-dependent 7-cyano-7-deazaguanine reductase [queF]. 1 122 46.723 T 13-10-2018 IPR016856 NADPH-dependent 7-cyano-7-deazaguanine reductase, QueF type 1 GO:0005737|GO:0008616|GO:0046857|GO:0055114 KEGG: 00790+1.7.1.13|MetaCyc: PWY-6700 TOPB45_1307 09102265f0ec19417bb67e0f0b2e461f 122 PIRSF PIRSF027377 1 122 3.2E-53 T 13-10-2018 IPR016856 NADPH-dependent 7-cyano-7-deazaguanine reductase, QueF type 1 GO:0005737|GO:0008616|GO:0046857|GO:0055114 KEGG: 00790+1.7.1.13|MetaCyc: PWY-6700 TOPB45_1307 09102265f0ec19417bb67e0f0b2e461f 122 Gene3D G3DSA:3.30.1130.10 8 122 2.2E-42 T 13-10-2018 TOPB45_1307 09102265f0ec19417bb67e0f0b2e461f 122 SUPERFAMILY SSF55620 4 115 6.82E-32 T 13-10-2018 TOPB45_0475 86da666f25993aed14bd39294b5ee781 160 Pfam PF06835 Lipopolysaccharide-assembly, LptC-related 48 155 1.2E-10 T 13-10-2018 IPR010664 Lipopolysaccharide assembly, LptC-related TOPB45_0475 86da666f25993aed14bd39294b5ee781 160 TIGRFAM TIGR04409 LptC_YrbK: LPS export ABC transporter periplasmic protein LptC 47 156 7.5E-15 T 13-10-2018 IPR026265 Lipopolysaccharide export system protein LptC GO:0005887|GO:0015221|GO:0015920 TOPB45_1086 3d3a904a1a4386cded6426094bfdf457 136 Pfam PF05168 HEPN domain 9 131 3.4E-33 T 13-10-2018 IPR007842 HEPN domain TOPB45_1086 3d3a904a1a4386cded6426094bfdf457 136 SMART SM00748 13 125 2.3E-29 T 13-10-2018 IPR007842 HEPN domain TOPB45_1086 3d3a904a1a4386cded6426094bfdf457 136 SUPERFAMILY SSF81593 7 132 9.81E-37 T 13-10-2018 TOPB45_1086 3d3a904a1a4386cded6426094bfdf457 136 Gene3D G3DSA:1.20.120.330 1 135 1.1E-42 T 13-10-2018 TOPB45_0648 574b70a611f3216d66830fcb3768fe77 214 SUPERFAMILY SSF53323 20 209 4.32E-42 T 13-10-2018 IPR002869 Pyruvate-flavodoxin oxidoreductase, central domain GO:0016491|GO:0055114 TOPB45_0648 574b70a611f3216d66830fcb3768fe77 214 Pfam PF01558 Pyruvate ferredoxin/flavodoxin oxidoreductase 29 203 3.0E-38 T 13-10-2018 IPR019752 Pyruvate/ketoisovalerate oxidoreductase, catalytic domain GO:0016903|GO:0055114 TOPB45_0648 574b70a611f3216d66830fcb3768fe77 214 Gene3D G3DSA:3.40.920.10 18 213 2.3E-52 T 13-10-2018 IPR002869 Pyruvate-flavodoxin oxidoreductase, central domain GO:0016491|GO:0055114 TOPB45_1043 b0eecbc2e9830e85fddd3388ce206575 361 Gene3D G3DSA:1.20.272.10 210 360 6.9E-10 T 13-10-2018 TOPB45_1043 b0eecbc2e9830e85fddd3388ce206575 361 SUPERFAMILY SSF52540 7 209 3.72E-10 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1043 b0eecbc2e9830e85fddd3388ce206575 361 Gene3D G3DSA:1.10.8.60 147 208 5.2E-9 T 13-10-2018 TOPB45_1213 4fa99994d7f066b5511cf4f855007caa 437 Gene3D G3DSA:3.50.50.60 2 186 5.6E-51 T 13-10-2018 IPR036188 FAD/NAD(P)-binding domain superfamily TOPB45_1213 4fa99994d7f066b5511cf4f855007caa 437 Gene3D G3DSA:3.50.50.60 282 437 2.5E-56 T 13-10-2018 IPR036188 FAD/NAD(P)-binding domain superfamily TOPB45_1213 4fa99994d7f066b5511cf4f855007caa 437 SUPERFAMILY SSF51905 2 365 4.92E-24 T 13-10-2018 IPR036188 FAD/NAD(P)-binding domain superfamily TOPB45_1213 4fa99994d7f066b5511cf4f855007caa 437 TIGRFAM TIGR00137 gid_trmFO: tRNA:m(5)U-54 methyltransferase 4 433 6.0E-201 T 13-10-2018 IPR004417 Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO GO:0005737|GO:0008033|GO:0047151|GO:0050660 TOPB45_1213 4fa99994d7f066b5511cf4f855007caa 437 Hamap MF_01037 Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO [trmFO]. 4 432 35.753 T 13-10-2018 IPR004417 Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO GO:0005737|GO:0008033|GO:0047151|GO:0050660 TOPB45_1213 4fa99994d7f066b5511cf4f855007caa 437 Pfam PF01134 Glucose inhibited division protein A 3 366 1.3E-107 T 13-10-2018 IPR002218 tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG-related GO:0008033|GO:0050660 Reactome: R-HSA-6787450 TOPB45_1213 4fa99994d7f066b5511cf4f855007caa 437 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 333 340 3.6E-6 T 13-10-2018 TOPB45_1213 4fa99994d7f066b5511cf4f855007caa 437 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 130 139 3.6E-6 T 13-10-2018 TOPB45_1213 4fa99994d7f066b5511cf4f855007caa 437 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 3 25 3.6E-6 T 13-10-2018 TOPB45_0440 c5b8d58309e5371c38625338722671df 369 Pfam PF12698 ABC-2 family transporter protein 23 359 1.6E-42 T 13-10-2018 TOPB45_0440 c5b8d58309e5371c38625338722671df 369 Gene3D G3DSA:3.40.1710.10 43 160 8.8E-7 T 13-10-2018 TOPB45_0181 c40ed60ff517151ae8806f10555de0f5 217 Pfam PF13419 Haloacid dehalogenase-like hydrolase 7 179 5.0E-23 T 13-10-2018 TOPB45_0181 c40ed60ff517151ae8806f10555de0f5 217 SUPERFAMILY SSF56784 5 203 2.53E-35 T 13-10-2018 IPR036412 HAD-like superfamily TOPB45_0181 c40ed60ff517151ae8806f10555de0f5 217 Gene3D G3DSA:3.40.50.1000 8 180 2.2E-34 T 13-10-2018 IPR023214 HAD superfamily TOPB45_0181 c40ed60ff517151ae8806f10555de0f5 217 Gene3D G3DSA:1.10.150.240 18 86 2.2E-34 T 13-10-2018 IPR023198 Phosphoglycolate phosphatase-like, domain 2 TOPB45_0343 4418f354597ae0fe9ffd3b5ec708d998 76 Pfam PF00483 Nucleotidyl transferase 6 74 4.0E-20 T 13-10-2018 IPR005835 Nucleotidyl transferase domain GO:0009058|GO:0016779 TOPB45_0343 4418f354597ae0fe9ffd3b5ec708d998 76 Gene3D G3DSA:3.90.550.10 1 75 1.5E-22 T 13-10-2018 IPR029044 Nucleotide-diphospho-sugar transferases TOPB45_0343 4418f354597ae0fe9ffd3b5ec708d998 76 SUPERFAMILY SSF53448 5 74 9.81E-27 T 13-10-2018 IPR029044 Nucleotide-diphospho-sugar transferases TOPB45_0595 2a6686af6d1fa53ec3dcebd7d9d3b092 261 Pfam PF08543 Phosphomethylpyrimidine kinase 14 248 2.7E-58 T 13-10-2018 IPR013749 Pyridoxamine kinase/Phosphomethylpyrimidine kinase Reactome: R-HSA-6798695|Reactome: R-HSA-964975 TOPB45_0595 2a6686af6d1fa53ec3dcebd7d9d3b092 261 SUPERFAMILY SSF53613 5 248 3.59E-53 T 13-10-2018 IPR029056 Ribokinase-like TOPB45_0595 2a6686af6d1fa53ec3dcebd7d9d3b092 261 Gene3D G3DSA:3.40.1190.20 3 258 3.2E-68 T 13-10-2018 IPR029056 Ribokinase-like TOPB45_0493 1e7d77b2641872de9715109b3d1a9618 66 SMART SM00834 1 43 5.4E-8 T 13-10-2018 IPR013429 Putative regulatory protein, FmdB, Zinc ribbon domain TOPB45_0493 1e7d77b2641872de9715109b3d1a9618 66 TIGRFAM TIGR02605 CxxC_CxxC_SSSS: putative regulatory protein, FmdB family 1 45 1.3E-12 T 13-10-2018 IPR013429 Putative regulatory protein, FmdB, Zinc ribbon domain TOPB45_0493 1e7d77b2641872de9715109b3d1a9618 66 Gene3D G3DSA:2.20.28.30 3 45 3.7E-6 T 13-10-2018 TOPB45_0493 1e7d77b2641872de9715109b3d1a9618 66 Pfam PF09723 Zinc ribbon domain 1 42 5.1E-13 T 13-10-2018 IPR013429 Putative regulatory protein, FmdB, Zinc ribbon domain TOPB45_0865 7948df3b0dcd970612ae2c5ec0e7c636 777 SUPERFAMILY SSF52540 534 756 1.39E-10 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0865 7948df3b0dcd970612ae2c5ec0e7c636 777 Gene3D G3DSA:3.40.50.300 520 770 9.3E-20 T 13-10-2018 TOPB45_0687 8d52431c41f5a7d07f749e130e136453 1210 SUPERFAMILY SSF103515 931 1210 1.44E-23 T 13-10-2018 IPR036709 Autotransporter beta-domain superfamily TOPB45_0687 8d52431c41f5a7d07f749e130e136453 1210 Gene3D G3DSA:2.40.128.130 935 1210 2.8E-23 T 13-10-2018 IPR036709 Autotransporter beta-domain superfamily TOPB45_0687 8d52431c41f5a7d07f749e130e136453 1210 SMART SM00869 935 1200 2.4E-18 T 13-10-2018 IPR005546 Autotransporter beta-domain TOPB45_0687 8d52431c41f5a7d07f749e130e136453 1210 Pfam PF03797 Autotransporter beta-domain 949 1188 2.1E-22 T 13-10-2018 IPR005546 Autotransporter beta-domain TOPB45_0033 92c7f8e0a0b5b32b0158e369f49727de 338 Pfam PF02470 MlaD protein 40 115 7.4E-19 T 13-10-2018 IPR003399 Mce/MlaD TOPB45_0190 5a328c89c75e86f056d5d66cb3198894 118 Pfam PF01250 Ribosomal protein S6 14 101 8.3E-27 T 13-10-2018 IPR000529 Ribosomal protein S6 GO:0003735|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0190 5a328c89c75e86f056d5d66cb3198894 118 Gene3D G3DSA:3.30.70.60 5 109 1.4E-30 T 13-10-2018 IPR014717 Translation elongation factor EF1B/ribosomal protein S6 TOPB45_0190 5a328c89c75e86f056d5d66cb3198894 118 Hamap MF_00360 30S ribosomal protein S6 [rpsF]. 11 104 19.116 T 13-10-2018 IPR020814 Ribosomal protein S6, plastid/chloroplast GO:0003735|GO:0005840|GO:0006412|GO:0019843 TOPB45_0190 5a328c89c75e86f056d5d66cb3198894 118 TIGRFAM TIGR00166 S6: ribosomal protein bS6 12 103 4.9E-24 T 13-10-2018 IPR000529 Ribosomal protein S6 GO:0003735|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0190 5a328c89c75e86f056d5d66cb3198894 118 SUPERFAMILY SSF54995 12 105 1.44E-28 T 13-10-2018 IPR035980 Ribosomal protein S6 superfamily GO:0003735|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 TOPB45_0052 67066e27411142e8c19b4606be2d9264 295 Pfam PF07728 AAA domain (dynein-related subfamily) 51 180 1.1E-19 T 13-10-2018 IPR011704 ATPase, dynein-related, AAA domain GO:0005524|GO:0016887 TOPB45_0052 67066e27411142e8c19b4606be2d9264 295 SMART SM00382 45 191 0.0085 T 13-10-2018 IPR003593 AAA+ ATPase domain TOPB45_0052 67066e27411142e8c19b4606be2d9264 295 SUPERFAMILY SSF52540 11 258 6.53E-29 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0052 67066e27411142e8c19b4606be2d9264 295 Gene3D G3DSA:3.40.50.300 48 200 1.4E-27 T 13-10-2018 TOPB45_1602 4b60a512ad589f5a981599aad11fa994 228 Pfam PF13483 Beta-lactamase superfamily domain 2 190 1.3E-30 T 13-10-2018 TOPB45_1602 4b60a512ad589f5a981599aad11fa994 228 Gene3D G3DSA:3.60.15.10 1 228 5.3E-71 T 13-10-2018 IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like TOPB45_1602 4b60a512ad589f5a981599aad11fa994 228 SUPERFAMILY SSF56281 1 227 5.08E-40 T 13-10-2018 IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like TOPB45_1602 4b60a512ad589f5a981599aad11fa994 228 Hamap MF_00457 UPF0173 metal-dependent hydrolase . 1 228 37.618 T 13-10-2018 IPR022877 Protein of unknown funcion UPF0173 TOPB45_1602 4b60a512ad589f5a981599aad11fa994 228 SMART SM00849 7 190 1.4E-13 T 13-10-2018 IPR001279 Metallo-beta-lactamase TOPB45_1005 489e549cf1e9713f0aa5874295e6f630 278 SUPERFAMILY SSF53807 27 276 1.57E-42 T 13-10-2018 TOPB45_1005 489e549cf1e9713f0aa5874295e6f630 278 Gene3D G3DSA:3.40.50.1980 26 165 4.6E-26 T 13-10-2018 TOPB45_1005 489e549cf1e9713f0aa5874295e6f630 278 Pfam PF01297 Zinc-uptake complex component A periplasmic 29 274 1.3E-38 T 13-10-2018 IPR006127 Periplasmic solute binding protein, ZnuA-like GO:0030001|GO:0046872 TOPB45_1005 489e549cf1e9713f0aa5874295e6f630 278 Gene3D G3DSA:3.40.50.1980 170 276 6.6E-9 T 13-10-2018 TOPB45_0562 5c56832f7b2182d20a397841741bca08 162 Pfam PF12850 Calcineurin-like phosphoesterase superfamily domain 1 154 6.2E-30 T 13-10-2018 IPR024654 Calcineurin-like phosphoesterase domain, lpxH type Reactome: R-HSA-3238698 TOPB45_0562 5c56832f7b2182d20a397841741bca08 162 TIGRFAM TIGR00040 yfcE: phosphodiesterase, MJ0936 family 1 158 1.4E-26 T 13-10-2018 IPR000979 Phosphodiesterase MJ0936/Vps29 Reactome: R-HSA-3238698 TOPB45_0562 5c56832f7b2182d20a397841741bca08 162 Gene3D G3DSA:3.60.21.10 1 162 3.4E-44 T 13-10-2018 IPR029052 Metallo-dependent phosphatase-like TOPB45_0562 5c56832f7b2182d20a397841741bca08 162 SUPERFAMILY SSF56300 1 156 8.91E-34 T 13-10-2018 TOPB45_0183 59752d26bc5cc5860f14e521849031d4 248 TIGRFAM TIGR00046 TIGR00046: RNA methyltransferase, RsmE family 18 242 2.3E-48 T 13-10-2018 IPR006700 Ribosomal RNA small subunit methyltransferase E GO:0006364|GO:0008168 TOPB45_0183 59752d26bc5cc5860f14e521849031d4 248 Pfam PF04452 RNA methyltransferase 19 240 3.7E-55 T 13-10-2018 IPR006700 Ribosomal RNA small subunit methyltransferase E GO:0006364|GO:0008168 TOPB45_0183 59752d26bc5cc5860f14e521849031d4 248 SUPERFAMILY SSF88697 14 60 5.96E-10 T 13-10-2018 IPR015947 PUA-like superfamily TOPB45_0183 59752d26bc5cc5860f14e521849031d4 248 SUPERFAMILY SSF75217 78 244 2.62E-36 T 13-10-2018 IPR029028 Alpha/beta knot methyltransferases TOPB45_0183 59752d26bc5cc5860f14e521849031d4 248 Gene3D G3DSA:3.40.1280.10 6 245 2.2E-62 T 13-10-2018 IPR029026 tRNA (guanine-N1-)-methyltransferase, N-terminal TOPB45_0183 59752d26bc5cc5860f14e521849031d4 248 PIRSF PIRSF015601 7 245 1.1E-53 T 13-10-2018 IPR006700 Ribosomal RNA small subunit methyltransferase E GO:0006364|GO:0008168 TOPB45_0482 00c5fb70cbbf67b419cabafc9d904c94 402 SUPERFAMILY SSF53756 28 400 2.12E-52 T 13-10-2018 TOPB45_0482 00c5fb70cbbf67b419cabafc9d904c94 402 Gene3D G3DSA:3.40.50.2000 188 382 1.9E-140 T 13-10-2018 TOPB45_0482 00c5fb70cbbf67b419cabafc9d904c94 402 Pfam PF00534 Glycosyl transferases group 1 208 376 3.1E-30 T 13-10-2018 IPR001296 Glycosyl transferase, family 1 TOPB45_0482 00c5fb70cbbf67b419cabafc9d904c94 402 Gene3D G3DSA:3.40.50.2000 3 383 1.9E-140 T 13-10-2018 TOPB45_0350 4fa48be9fcc713c1c6663413e47e886a 369 Pfam PF13439 Glycosyltransferase Family 4 15 170 2.4E-19 T 13-10-2018 IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain Reactome: R-HSA-446193|Reactome: R-HSA-4549349 TOPB45_0350 4fa48be9fcc713c1c6663413e47e886a 369 Gene3D G3DSA:3.40.50.2000 166 350 1.9E-74 T 13-10-2018 TOPB45_0350 4fa48be9fcc713c1c6663413e47e886a 369 SUPERFAMILY SSF53756 10 364 4.19E-76 T 13-10-2018 TOPB45_0350 4fa48be9fcc713c1c6663413e47e886a 369 Gene3D G3DSA:3.40.50.2000 15 359 1.9E-74 T 13-10-2018 TOPB45_0350 4fa48be9fcc713c1c6663413e47e886a 369 Pfam PF00534 Glycosyl transferases group 1 186 345 2.0E-42 T 13-10-2018 IPR001296 Glycosyl transferase, family 1 TOPB45_1387 c00a0f441926f64eac9a2155c06a55db 144 Gene3D G3DSA:3.40.630.30 2 144 1.3E-38 T 13-10-2018 TOPB45_1387 c00a0f441926f64eac9a2155c06a55db 144 TIGRFAM TIGR01575 rimI: ribosomal-protein-alanine acetyltransferase 13 140 3.5E-35 T 13-10-2018 IPR006464 N-acetyltransferase RimI/Ard1 GO:0006474|GO:0016407 TOPB45_1387 c00a0f441926f64eac9a2155c06a55db 144 Pfam PF00583 Acetyltransferase (GNAT) family 17 122 2.9E-23 T 13-10-2018 IPR000182 GNAT domain TOPB45_1387 c00a0f441926f64eac9a2155c06a55db 144 SUPERFAMILY SSF55729 3 142 1.66E-33 T 13-10-2018 IPR016181 Acyl-CoA N-acyltransferase TOPB45_0363 ac7cc1c6a0113311b4d62daf1ebe11a3 413 Pfam PF02706 Chain length determinant protein 11 111 2.4E-16 T 13-10-2018 IPR003856 Polysaccharide chain length determinant N-terminal domain GO:0009103|GO:0016020 TOPB45_0363 ac7cc1c6a0113311b4d62daf1ebe11a3 413 Pfam PF13807 G-rich domain on putative tyrosine kinase 293 372 1.8E-11 T 13-10-2018 IPR032807 Tyrosine kinase, G-rich domain TOPB45_0386 15138566b127a81f284685938cc66969 270 Pfam PF03692 Putative zinc- or iron-chelating domain 35 126 1.9E-9 T 13-10-2018 IPR005358 Putative zinc- or iron-chelating domain containing protein TOPB45_0917 a1ef9c3c0b8c10c5d0250e9901520afc 401 PRINTS PR00812 Bacterial general secretion pathway protein F signature 363 377 9.0E-9 T 13-10-2018 IPR003004 GspF/PilC family TOPB45_0917 a1ef9c3c0b8c10c5d0250e9901520afc 401 PRINTS PR00812 Bacterial general secretion pathway protein F signature 379 398 9.0E-9 T 13-10-2018 IPR003004 GspF/PilC family TOPB45_0917 a1ef9c3c0b8c10c5d0250e9901520afc 401 PRINTS PR00812 Bacterial general secretion pathway protein F signature 158 186 9.0E-9 T 13-10-2018 IPR003004 GspF/PilC family TOPB45_0917 a1ef9c3c0b8c10c5d0250e9901520afc 401 PRINTS PR00812 Bacterial general secretion pathway protein F signature 60 72 9.0E-9 T 13-10-2018 IPR003004 GspF/PilC family TOPB45_0917 a1ef9c3c0b8c10c5d0250e9901520afc 401 Gene3D G3DSA:1.20.81.30 51 166 2.8E-28 T 13-10-2018 TOPB45_0917 a1ef9c3c0b8c10c5d0250e9901520afc 401 Gene3D G3DSA:1.20.81.30 251 362 1.9E-18 T 13-10-2018 TOPB45_0917 a1ef9c3c0b8c10c5d0250e9901520afc 401 Pfam PF00482 Type II secretion system (T2SS), protein F 268 388 1.2E-18 T 13-10-2018 IPR018076 Type II secretion system F domain TOPB45_0917 a1ef9c3c0b8c10c5d0250e9901520afc 401 Pfam PF00482 Type II secretion system (T2SS), protein F 64 186 4.1E-23 T 13-10-2018 IPR018076 Type II secretion system F domain TOPB45_0043 fb420ee65b8b3c44ec91e84eb15c484c 197 Gene3D G3DSA:3.10.580.10 1 148 6.5E-39 T 13-10-2018 TOPB45_0043 fb420ee65b8b3c44ec91e84eb15c484c 197 SMART SM00116 72 119 3.7E-13 T 13-10-2018 IPR000644 CBS domain TOPB45_0043 fb420ee65b8b3c44ec91e84eb15c484c 197 SMART SM00116 10 57 1.6E-13 T 13-10-2018 IPR000644 CBS domain TOPB45_0043 fb420ee65b8b3c44ec91e84eb15c484c 197 Pfam PF00571 CBS domain 66 118 8.3E-15 T 13-10-2018 IPR000644 CBS domain TOPB45_0043 fb420ee65b8b3c44ec91e84eb15c484c 197 Pfam PF00571 CBS domain 3 57 1.1E-14 T 13-10-2018 IPR000644 CBS domain TOPB45_0043 fb420ee65b8b3c44ec91e84eb15c484c 197 SUPERFAMILY SSF54631 1 120 9.1E-38 T 13-10-2018 TOPB45_0505 8e9cef7547b0cddecad77ad50953e895 997 Pfam PF12705 PD-(D/E)XK nuclease superfamily 676 990 6.8E-21 T 13-10-2018 IPR038726 PD-(D/E)XK endonuclease-like domain, AddAB-type TOPB45_0505 8e9cef7547b0cddecad77ad50953e895 997 SUPERFAMILY SSF52540 276 645 1.73E-24 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1065 d35aa40c9c1d58359f124001b2542127 278 Gene3D G3DSA:3.40.50.620 138 277 4.4E-22 T 13-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TOPB45_1065 d35aa40c9c1d58359f124001b2542127 278 SUPERFAMILY SSF52402 141 274 2.6E-18 T 13-10-2018 TOPB45_1065 d35aa40c9c1d58359f124001b2542127 278 SUPERFAMILY SSF52402 3 136 7.2E-12 T 13-10-2018 TOPB45_1065 d35aa40c9c1d58359f124001b2542127 278 Gene3D G3DSA:3.40.50.620 1 134 3.6E-8 T 13-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TOPB45_1065 d35aa40c9c1d58359f124001b2542127 278 Pfam PF00582 Universal stress protein family 141 274 6.6E-17 T 13-10-2018 IPR006016 UspA TOPB45_0311 0f4e1b8ebac3bf209f8b83ecda125f8c 287 Pfam PF01988 VIT family 135 191 1.1E-8 T 13-10-2018 IPR008217 Ccc1 family TOPB45_0311 0f4e1b8ebac3bf209f8b83ecda125f8c 287 SUPERFAMILY SSF47240 2 126 3.45E-11 T 13-10-2018 IPR009078 Ferritin-like superfamily TOPB45_0088 7e6f8d0e4fa43777332d67e910100055 218 Gene3D G3DSA:2.60.40.4070 98 183 4.0E-24 T 13-10-2018 TOPB45_0088 7e6f8d0e4fa43777332d67e910100055 218 Pfam PF13860 FlgD Ig-like domain 111 170 2.4E-16 T 13-10-2018 IPR025965 FlgD Ig-like domain TOPB45_0088 7e6f8d0e4fa43777332d67e910100055 218 Gene3D G3DSA:2.30.30.910 87 212 4.0E-24 T 13-10-2018 TOPB45_0088 7e6f8d0e4fa43777332d67e910100055 218 Pfam PF03963 Flagellar hook capping protein - N-terminal region 7 72 2.6E-16 T 13-10-2018 IPR005648 Flagellar hook capping protein TOPB45_0068 d8e7a7e1e7e75f5d69dd7bdad7334089 836 SUPERFAMILY SSF159501 616 792 2.04E-10 T 13-10-2018 TOPB45_0068 d8e7a7e1e7e75f5d69dd7bdad7334089 836 Pfam PF04187 Haem-binding uptake, Tiki superfamily, ChaN 624 796 5.1E-13 T 13-10-2018 IPR007314 Haem-binding uptake, Tiki superfamily, ChaN TOPB45_0060 ee5414f74c6b8f715f09e9059bd0331d 514 PRINTS PR01009 Flagellar M-ring protein signature 336 360 6.8E-37 T 13-10-2018 IPR000067 Flagellar M-ring protein FliF GO:0003774|GO:0009431|GO:0071973 TOPB45_0060 ee5414f74c6b8f715f09e9059bd0331d 514 PRINTS PR01009 Flagellar M-ring protein signature 262 280 6.8E-37 T 13-10-2018 IPR000067 Flagellar M-ring protein FliF GO:0003774|GO:0009431|GO:0071973 TOPB45_0060 ee5414f74c6b8f715f09e9059bd0331d 514 PRINTS PR01009 Flagellar M-ring protein signature 118 136 6.8E-37 T 13-10-2018 IPR000067 Flagellar M-ring protein FliF GO:0003774|GO:0009431|GO:0071973 TOPB45_0060 ee5414f74c6b8f715f09e9059bd0331d 514 PRINTS PR01009 Flagellar M-ring protein signature 150 164 6.8E-37 T 13-10-2018 IPR000067 Flagellar M-ring protein FliF GO:0003774|GO:0009431|GO:0071973 TOPB45_0060 ee5414f74c6b8f715f09e9059bd0331d 514 PRINTS PR01009 Flagellar M-ring protein signature 193 211 6.8E-37 T 13-10-2018 IPR000067 Flagellar M-ring protein FliF GO:0003774|GO:0009431|GO:0071973 TOPB45_0060 ee5414f74c6b8f715f09e9059bd0331d 514 TIGRFAM TIGR00206 fliF: flagellar M-ring protein FliF 10 426 4.9E-99 T 13-10-2018 IPR000067 Flagellar M-ring protein FliF GO:0003774|GO:0009431|GO:0071973 TOPB45_0060 ee5414f74c6b8f715f09e9059bd0331d 514 Pfam PF08345 Flagellar M-ring protein C-terminal 249 403 2.9E-34 T 13-10-2018 IPR013556 Flagellar M-ring C-terminal TOPB45_0060 ee5414f74c6b8f715f09e9059bd0331d 514 PIRSF PIRSF004862 1 478 1.2E-126 T 13-10-2018 IPR000067 Flagellar M-ring protein FliF GO:0003774|GO:0009431|GO:0071973 TOPB45_0060 ee5414f74c6b8f715f09e9059bd0331d 514 PIRSF PIRSF004862 473 501 0.21 T 13-10-2018 IPR000067 Flagellar M-ring protein FliF GO:0003774|GO:0009431|GO:0071973 TOPB45_0060 ee5414f74c6b8f715f09e9059bd0331d 514 Gene3D G3DSA:3.30.300.30 119 221 3.1E-13 T 13-10-2018 TOPB45_0060 ee5414f74c6b8f715f09e9059bd0331d 514 Pfam PF01514 Secretory protein of YscJ/FliF family 32 212 7.7E-67 T 13-10-2018 IPR006182 Secretory protein YscJ/FliF TOPB45_0049 5807d08e9fca01fbf29971b940fc388c 327 Gene3D G3DSA:1.10.3720.10 92 314 3.4E-19 T 13-10-2018 IPR035906 MetI-like superfamily TOPB45_0049 5807d08e9fca01fbf29971b940fc388c 327 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 117 323 2.2E-41 T 13-10-2018 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0016020|GO:0055085 TOPB45_0049 5807d08e9fca01fbf29971b940fc388c 327 SUPERFAMILY SSF161098 92 306 5.45E-18 T 13-10-2018 IPR035906 MetI-like superfamily TOPB45_1495 a7e5621f7fb9a7be35027eebfdf0958a 420 SUPERFAMILY SSF82171 67 418 1.39E-16 T 13-10-2018 TOPB45_1495 a7e5621f7fb9a7be35027eebfdf0958a 420 Gene3D G3DSA:2.120.10.30 345 418 2.8E-6 T 13-10-2018 IPR011042 Six-bladed beta-propeller, TolB-like TOPB45_1495 a7e5621f7fb9a7be35027eebfdf0958a 420 Gene3D G3DSA:2.120.10.30 269 344 1.7E-5 T 13-10-2018 IPR011042 Six-bladed beta-propeller, TolB-like TOPB45_0807 53c59da1c5e68d1243ab7a670fd1a456 380 Gene3D G3DSA:2.130.10.10 99 366 1.8E-7 T 13-10-2018 IPR015943 WD40/YVTN repeat-like-containing domain superfamily GO:0005515 TOPB45_0807 53c59da1c5e68d1243ab7a670fd1a456 380 SUPERFAMILY SSF50978 47 363 5.13E-15 T 13-10-2018 IPR036322 WD40-repeat-containing domain superfamily GO:0005515 TOPB45_1131 2bcb07abea7e7cf18c8f2049ba8c3a1b 331 Pfam PF00579 tRNA synthetases class I (W and Y) 3 281 2.3E-65 T 13-10-2018 IPR002305 Aminoacyl-tRNA synthetase, class Ic GO:0000166|GO:0004812|GO:0005524|GO:0006418 TOPB45_1131 2bcb07abea7e7cf18c8f2049ba8c3a1b 331 ProSitePatterns PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 12 21 - T 13-10-2018 IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site GO:0000166|GO:0004812|GO:0005524|GO:0006418 TOPB45_1131 2bcb07abea7e7cf18c8f2049ba8c3a1b 331 TIGRFAM TIGR00233 trpS: tryptophan--tRNA ligase 3 322 4.6E-90 T 13-10-2018 IPR002306 Tryptophan-tRNA ligase GO:0000166|GO:0004830|GO:0005524|GO:0005737|GO:0006436 KEGG: 00970+6.1.1.2 TOPB45_1131 2bcb07abea7e7cf18c8f2049ba8c3a1b 331 SUPERFAMILY SSF52374 4 321 4.02E-85 T 13-10-2018 TOPB45_1131 2bcb07abea7e7cf18c8f2049ba8c3a1b 331 Gene3D G3DSA:3.40.50.620 6 322 4.7E-111 T 13-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TOPB45_1131 2bcb07abea7e7cf18c8f2049ba8c3a1b 331 PRINTS PR01039 Tryptophanyl-tRNA synthetase signature 67 86 6.4E-24 T 13-10-2018 IPR002306 Tryptophan-tRNA ligase GO:0000166|GO:0004830|GO:0005524|GO:0005737|GO:0006436 KEGG: 00970+6.1.1.2 TOPB45_1131 2bcb07abea7e7cf18c8f2049ba8c3a1b 331 PRINTS PR01039 Tryptophanyl-tRNA synthetase signature 145 166 6.4E-24 T 13-10-2018 IPR002306 Tryptophan-tRNA ligase GO:0000166|GO:0004830|GO:0005524|GO:0005737|GO:0006436 KEGG: 00970+6.1.1.2 TOPB45_1131 2bcb07abea7e7cf18c8f2049ba8c3a1b 331 PRINTS PR01039 Tryptophanyl-tRNA synthetase signature 196 206 6.4E-24 T 13-10-2018 IPR002306 Tryptophan-tRNA ligase GO:0000166|GO:0004830|GO:0005524|GO:0005737|GO:0006436 KEGG: 00970+6.1.1.2 TOPB45_1131 2bcb07abea7e7cf18c8f2049ba8c3a1b 331 PRINTS PR01039 Tryptophanyl-tRNA synthetase signature 16 32 6.4E-24 T 13-10-2018 IPR002306 Tryptophan-tRNA ligase GO:0000166|GO:0004830|GO:0005524|GO:0005737|GO:0006436 KEGG: 00970+6.1.1.2 TOPB45_1131 2bcb07abea7e7cf18c8f2049ba8c3a1b 331 Gene3D G3DSA:1.10.240.10 191 296 4.7E-111 T 13-10-2018 TOPB45_0215 677a3025e7428ca7e26991a968bf432a 104 Pfam PF05258 Protein of unknown function (DUF721) 4 82 1.0E-9 T 13-10-2018 IPR007922 Protein of unknown function DUF721/UPF0232 TOPB45_0215 677a3025e7428ca7e26991a968bf432a 104 Gene3D G3DSA:3.30.300.180 20 96 1.9E-5 T 13-10-2018 IPR038454 DnaA, N-terminal domain superfamily TOPB45_0910 47eeb6fd01e70c5ab4b90bb39d822556 168 Pfam PF07012 Curlin associated repeat 98 123 4.2E-5 T 13-10-2018 IPR009742 Curlin associated GO:0007155|GO:0009289 TOPB45_0352 f1fcfe67ad7c4ff318b614fbb3b451ab 85 SUPERFAMILY SSF143100 5 53 5.62E-13 T 13-10-2018 IPR035069 TTHA1013/TTHA0281-like TOPB45_0352 f1fcfe67ad7c4ff318b614fbb3b451ab 85 Gene3D G3DSA:3.30.160.250 5 73 2.9E-12 T 13-10-2018 TOPB45_1034 349a232545270993737eb52b8bb0e281 691 Gene3D G3DSA:3.40.1380.40 420 549 6.9E-15 T 13-10-2018 TOPB45_1034 349a232545270993737eb52b8bb0e281 691 Pfam PF02516 Oligosaccharyl transferase STT3 subunit 43 473 3.5E-23 T 13-10-2018 IPR003674 Oligosaccharyl transferase, STT3 subunit GO:0004576|GO:0006486|GO:0016020 TOPB45_0474 ae4244c69e2c7a7138391ba949cf94a8 247 SUPERFAMILY SSF47781 55 88 7.04E-5 T 13-10-2018 IPR010994 RuvA domain 2-like TOPB45_0474 ae4244c69e2c7a7138391ba949cf94a8 247 TIGRFAM TIGR00608 radc: DNA repair protein RadC 23 235 4.1E-60 T 13-10-2018 IPR001405 Uncharacterised protein family UPF0758 TOPB45_0474 ae4244c69e2c7a7138391ba949cf94a8 247 Pfam PF04002 RadC-like JAB domain 115 233 5.9E-42 T 13-10-2018 IPR025657 RadC-like JAB domain TOPB45_0474 ae4244c69e2c7a7138391ba949cf94a8 247 ProSitePatterns PS01302 Uncharacterized protein family UPF0758 signature. 184 189 - T 13-10-2018 IPR020891 Uncharacterised protein family UPF0758, conserved site TOPB45_0474 ae4244c69e2c7a7138391ba949cf94a8 247 Gene3D G3DSA:3.40.140.10 111 235 3.5E-43 T 13-10-2018 TOPB45_0269 6904767e48aeb5c8974f76be1ee3d794 352 SMART SM00729 52 278 0.0018 T 13-10-2018 IPR006638 Elp3/MiaB/NifB GO:0003824|GO:0051536 TOPB45_0269 6904767e48aeb5c8974f76be1ee3d794 352 SUPERFAMILY SSF102114 14 342 1.7E-51 T 13-10-2018 TOPB45_0269 6904767e48aeb5c8974f76be1ee3d794 352 TIGRFAM TIGR00423 TIGR00423: radical SAM domain protein, CofH subfamily 48 349 1.4E-124 T 13-10-2018 IPR020050 FO synthase, subunit 2 GO:0016765 KEGG: 00680+2.5.1.77 TOPB45_0269 6904767e48aeb5c8974f76be1ee3d794 352 Gene3D G3DSA:3.20.20.70 1 347 1.5E-59 T 13-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 TOPB45_0269 6904767e48aeb5c8974f76be1ee3d794 352 Pfam PF04055 Radical SAM superfamily 56 228 4.1E-17 T 13-10-2018 IPR007197 Radical SAM GO:0003824|GO:0051536 TOPB45_0269 6904767e48aeb5c8974f76be1ee3d794 352 Hamap MF_00992 Cyclic dehypoxanthine futalosine synthase [mqnC]. 12 352 52.399 T 13-10-2018 IPR022431 Cyclic dehypoxanthine futalosine synthase GO:0009234 KEGG: 00130+1.21.98.1|MetaCyc: PWY-7371|MetaCyc: PWY-7374 TOPB45_0269 6904767e48aeb5c8974f76be1ee3d794 352 PIRSF PIRSF004762 1 351 2.6E-115 T 13-10-2018 TOPB45_0269 6904767e48aeb5c8974f76be1ee3d794 352 TIGRFAM TIGR03699 menaquin_MqnC: dehypoxanthine futalosine cyclase 13 350 2.7E-158 T 13-10-2018 IPR022431 Cyclic dehypoxanthine futalosine synthase GO:0009234 KEGG: 00130+1.21.98.1|MetaCyc: PWY-7371|MetaCyc: PWY-7374 TOPB45_1020 c6fc2218f563b8f0a1c8a427d2800873 260 Pfam PF01148 Cytidylyltransferase family 4 257 2.2E-48 T 13-10-2018 TOPB45_1342 de16d969f21d6f006c4bf5979e5ce474 336 SUPERFAMILY SSF56784 4 307 2.76E-17 T 13-10-2018 IPR036412 HAD-like superfamily TOPB45_1342 de16d969f21d6f006c4bf5979e5ce474 336 Gene3D G3DSA:1.10.3870.10 16 207 2.0E-88 T 13-10-2018 TOPB45_1342 de16d969f21d6f006c4bf5979e5ce474 336 Gene3D G3DSA:3.40.50.1000 7 284 2.0E-88 T 13-10-2018 IPR023214 HAD superfamily TOPB45_0185 8a839a4096c8b2d3059304b4e9358e1d 275 Pfam PF10670 Domain of unknown function (DUF4198) 56 232 9.1E-15 T 13-10-2018 IPR019613 Protein of unknown function DUF4198 TOPB45_0179 32ff30d63facffddf75dac67fea62f0a 469 Gene3D G3DSA:3.10.400.10 10 175 1.8E-25 T 13-10-2018 TOPB45_0179 32ff30d63facffddf75dac67fea62f0a 469 TIGRFAM TIGR00339 sopT: sulfate adenylyltransferase 12 429 8.1E-125 T 13-10-2018 IPR002650 Sulphate adenylyltransferase GO:0000103|GO:0004781 KEGG: 00230+2.7.7.4|KEGG: 00261+2.7.7.4|KEGG: 00450+2.7.7.4|KEGG: 00920+2.7.7.4|MetaCyc: PWY-5278|MetaCyc: PWY-5340|MetaCyc: PWY-6683|MetaCyc: PWY-6932|Reactome: R-HSA-174362|Reactome: R-HSA-2408550 TOPB45_0179 32ff30d63facffddf75dac67fea62f0a 469 SUPERFAMILY SSF88697 10 195 8.15E-28 T 13-10-2018 IPR015947 PUA-like superfamily TOPB45_0179 32ff30d63facffddf75dac67fea62f0a 469 SUPERFAMILY SSF52374 200 430 7.64E-59 T 13-10-2018 TOPB45_0179 32ff30d63facffddf75dac67fea62f0a 469 Pfam PF01747 ATP-sulfurylase 202 430 5.4E-67 T 13-10-2018 IPR024951 Sulphate adenylyltransferase catalytic domain GO:0004781 KEGG: 00230+2.7.7.4|KEGG: 00261+2.7.7.4|KEGG: 00450+2.7.7.4|KEGG: 00920+2.7.7.4|MetaCyc: PWY-5278|MetaCyc: PWY-5340|MetaCyc: PWY-6683|MetaCyc: PWY-6932|Reactome: R-HSA-174362|Reactome: R-HSA-2408550 TOPB45_0179 32ff30d63facffddf75dac67fea62f0a 469 Gene3D G3DSA:3.40.50.620 203 429 4.3E-62 T 13-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold TOPB45_0179 32ff30d63facffddf75dac67fea62f0a 469 Pfam PF14306 PUA-like domain 11 192 4.4E-27 T 13-10-2018 IPR025980 ATP-sulfurylase PUA-like domain KEGG: 00230+2.7.7.4|KEGG: 00261+2.7.7.4|KEGG: 00450+2.7.7.4|KEGG: 00920+2.7.7.4|MetaCyc: PWY-5278|MetaCyc: PWY-5340|MetaCyc: PWY-6683|MetaCyc: PWY-6932|Reactome: R-HSA-174362|Reactome: R-HSA-2408550 TOPB45_1235 e2bb6155379c2c6ac9a15c852050084f 457 Pfam PF13231 Dolichyl-phosphate-mannose-protein mannosyltransferase 60 215 8.7E-9 T 13-10-2018 IPR038731 Glycosyltransferase RgtA/B/C/D-like TOPB45_1428 0d53d198f22b4775d33ae03e80e3aada 434 PIRSF PIRSF006446 1 434 1.2E-176 T 13-10-2018 IPR002585 Cytochrome ubiquinol oxidase subunit 1 GO:0009055|GO:0019646|GO:0070069 TOPB45_1428 0d53d198f22b4775d33ae03e80e3aada 434 Pfam PF01654 Cytochrome bd terminal oxidase subunit I 6 429 6.9E-181 T 13-10-2018 IPR002585 Cytochrome ubiquinol oxidase subunit 1 GO:0009055|GO:0019646|GO:0070069 TOPB45_0329 c973e17606f43ec821599449d5970fb7 308 Pfam PF13635 Domain of unknown function (DUF4143) 119 256 6.1E-21 T 13-10-2018 IPR025420 Domain of unknown function DUF4143 TOPB45_0329 c973e17606f43ec821599449d5970fb7 308 Pfam PF13173 AAA domain 3 41 8.8E-8 T 13-10-2018 TOPB45_0478 b0445bfe56b7ec9890012e29fbec61ce 519 SUPERFAMILY SSF102114 205 505 2.22E-27 T 13-10-2018 TOPB45_0478 b0445bfe56b7ec9890012e29fbec61ce 519 SMART SM00729 205 411 3.0E-24 T 13-10-2018 IPR006638 Elp3/MiaB/NifB GO:0003824|GO:0051536 TOPB45_0478 b0445bfe56b7ec9890012e29fbec61ce 519 Pfam PF04055 Radical SAM superfamily 209 365 1.1E-13 T 13-10-2018 IPR007197 Radical SAM GO:0003824|GO:0051536 TOPB45_0478 b0445bfe56b7ec9890012e29fbec61ce 519 Gene3D G3DSA:3.80.30.20 204 420 1.0E-15 T 13-10-2018 IPR023404 Radical SAM, alpha/beta horseshoe TOPB45_0293 35f3b02a7d1d4be358d3d1f5d6358710 417 Pfam PF03349 Outer membrane protein transport protein (OMPP1/FadL/TodX) 28 329 1.1E-33 T 13-10-2018 IPR005017 Outer membrane protein transport protein (OMPP1/FadL/TodX) TOPB45_0293 35f3b02a7d1d4be358d3d1f5d6358710 417 SUPERFAMILY SSF56935 24 417 6.8E-70 T 13-10-2018 TOPB45_0293 35f3b02a7d1d4be358d3d1f5d6358710 417 Gene3D G3DSA:2.40.160.60 23 417 5.7E-78 T 13-10-2018 TOPB45_0513 a326274785357882ae30e88a42ebd36a 260 SUPERFAMILY SSF56112 49 200 5.55E-8 T 13-10-2018 IPR011009 Protein kinase-like domain superfamily TOPB45_0513 a326274785357882ae30e88a42ebd36a 260 Gene3D G3DSA:1.10.510.10 131 252 9.6E-6 T 13-10-2018 TOPB45_0437 663c33ca5ae5fd1558b43f3889f77103 350 Gene3D G3DSA:3.40.800.20 2 345 3.9E-109 T 13-10-2018 IPR037138 Histone deacetylase domain superfamily Reactome: R-HSA-2122947|Reactome: R-HSA-2644606|Reactome: R-HSA-2894862 TOPB45_0437 663c33ca5ae5fd1558b43f3889f77103 350 PRINTS PR01270 Histone deacetylase superfamily signature 240 250 1.4E-17 T 13-10-2018 IPR000286 Histone deacetylase family Reactome: R-HSA-2122947|Reactome: R-HSA-2644606|Reactome: R-HSA-2894862 TOPB45_0437 663c33ca5ae5fd1558b43f3889f77103 350 PRINTS PR01270 Histone deacetylase superfamily signature 122 145 1.4E-17 T 13-10-2018 IPR000286 Histone deacetylase family Reactome: R-HSA-2122947|Reactome: R-HSA-2644606|Reactome: R-HSA-2894862 TOPB45_0437 663c33ca5ae5fd1558b43f3889f77103 350 PRINTS PR01270 Histone deacetylase superfamily signature 156 171 1.4E-17 T 13-10-2018 IPR000286 Histone deacetylase family Reactome: R-HSA-2122947|Reactome: R-HSA-2644606|Reactome: R-HSA-2894862 TOPB45_0437 663c33ca5ae5fd1558b43f3889f77103 350 SUPERFAMILY SSF52768 2 315 2.01E-106 T 13-10-2018 IPR023696 Ureohydrolase domain superfamily TOPB45_0437 663c33ca5ae5fd1558b43f3889f77103 350 Pfam PF00850 Histone deacetylase domain 21 308 3.7E-83 T 13-10-2018 IPR023801 Histone deacetylase domain Reactome: R-HSA-2122947|Reactome: R-HSA-2644606|Reactome: R-HSA-2894862 TOPB45_1078 02a90a8f58d2988472f8862012b2dd3c 96 SUPERFAMILY SSF103007 1 94 3.27E-22 T 13-10-2018 IPR036746 TT1725-like superfamily TOPB45_1078 02a90a8f58d2988472f8862012b2dd3c 96 Pfam PF04456 Protein of unknown function (DUF503) 3 90 1.6E-26 T 13-10-2018 IPR007546 Protein of unknown function DUF503 TOPB45_1078 02a90a8f58d2988472f8862012b2dd3c 96 Gene3D G3DSA:3.30.70.1120 1 96 9.4E-26 T 13-10-2018 IPR036746 TT1725-like superfamily TOPB45_0801 f785d1af4d3ed6580d5ab6205b64adac 154 Gene3D G3DSA:3.40.50.1240 1 153 4.2E-27 T 13-10-2018 IPR029033 Histidine phosphatase superfamily TOPB45_0801 f785d1af4d3ed6580d5ab6205b64adac 154 SUPERFAMILY SSF53254 1 147 1.18E-14 T 13-10-2018 IPR029033 Histidine phosphatase superfamily TOPB45_0801 f785d1af4d3ed6580d5ab6205b64adac 154 TIGRFAM TIGR00249 sixA: phosphohistidine phosphatase SixA 1 150 5.8E-37 T 13-10-2018 IPR004449 Phosphohistidine phosphatase SixA GO:0005737|GO:0006464|GO:0101006 TOPB45_0801 f785d1af4d3ed6580d5ab6205b64adac 154 Pfam PF00300 Histidine phosphatase superfamily (branch 1) 4 78 5.3E-6 T 13-10-2018 IPR013078 Histidine phosphatase superfamily, clade-1 TOPB45_0328 51b9bb74bcbcf5491db06eb51207c5b9 441 Pfam PF03023 MviN-like protein 50 434 5.3E-19 T 13-10-2018 IPR004268 Peptidoglycan biosynthesis protein MurJ TOPB45_1182 50f4652c28c005d535d51e810f108538 76 SMART SM00899 2 74 1.5E-18 T 13-10-2018 IPR007167 Ferrous iron transporter FeoA domain GO:0046914 TOPB45_1182 50f4652c28c005d535d51e810f108538 76 Pfam PF04023 FeoA domain 4 73 1.7E-15 T 13-10-2018 IPR007167 Ferrous iron transporter FeoA domain GO:0046914 TOPB45_1182 50f4652c28c005d535d51e810f108538 76 Gene3D G3DSA:2.30.30.90 2 75 2.6E-23 T 13-10-2018 IPR038157 Ferrous iron transporter, core domain TOPB45_1182 50f4652c28c005d535d51e810f108538 76 SUPERFAMILY SSF50037 5 75 1.63E-20 T 13-10-2018 IPR008988 Transcriptional repressor, C-terminal TOPB45_0863 7dbc0db88153db19405a349a713c1e39 306 Pfam PF08349 Protein of unknown function (DUF1722) 185 299 5.5E-35 T 13-10-2018 IPR013560 Domain of unknown function DUF1722 TOPB45_0863 7dbc0db88153db19405a349a713c1e39 306 Pfam PF04463 Protein of unknown function (DUF523) 7 143 4.1E-31 T 13-10-2018 IPR007553 Domain of unknown function DUF523 TOPB45_0904 0deabbabbf0f7629fe57216b6d8fe56b 636 SUPERFAMILY SSF48452 256 365 2.4E-6 T 13-10-2018 IPR011990 Tetratricopeptide-like helical domain superfamily GO:0005515 TOPB45_0637 0aa238d01632e02d96132765b4310a22 381 Gene3D G3DSA:1.20.1090.10 186 380 4.3E-39 T 13-10-2018 TOPB45_0637 0aa238d01632e02d96132765b4310a22 381 Gene3D G3DSA:3.40.50.1970 1 183 8.2E-57 T 13-10-2018 TOPB45_0637 0aa238d01632e02d96132765b4310a22 381 Pfam PF00465 Iron-containing alcohol dehydrogenase 9 367 9.4E-98 T 13-10-2018 IPR001670 Alcohol dehydrogenase, iron-type/glycerol dehydrogenase GldA GO:0016491|GO:0046872|GO:0055114 Reactome: R-HSA-880009 TOPB45_0637 0aa238d01632e02d96132765b4310a22 381 SUPERFAMILY SSF56796 4 379 2.09E-102 T 13-10-2018 TOPB45_0585 6c7d242fbaf9f6f6ed97eb1a14545688 126 SUPERFAMILY SSF141734 5 118 2.62E-46 T 13-10-2018 IPR038019 Phosphoribosyl-AMP cyclohydrolase domain superfamily KEGG: 00340+3.5.4.19 TOPB45_0585 6c7d242fbaf9f6f6ed97eb1a14545688 126 Pfam PF01502 Phosphoribosyl-AMP cyclohydrolase 28 101 4.3E-32 T 13-10-2018 IPR002496 Phosphoribosyl-AMP cyclohydrolase domain GO:0000105|GO:0004635 KEGG: 00340+3.5.4.19 TOPB45_0585 6c7d242fbaf9f6f6ed97eb1a14545688 126 ProDom PD002610 PHOSPHORIBOSYL-AMP BIOSYNTHESIS CYCLOHYDROLASE HYDROLASE HISTIDINE AMINO-ACID PRA-CH PHOSPHORIBOSYL-ATP BIFUNCTIONAL INCLUDES: 51 104 2.0E-16 T 13-10-2018 IPR002496 Phosphoribosyl-AMP cyclohydrolase domain GO:0000105|GO:0004635 KEGG: 00340+3.5.4.19 TOPB45_0585 6c7d242fbaf9f6f6ed97eb1a14545688 126 Hamap MF_01021 Phosphoribosyl-AMP cyclohydrolase [hisI]. 2 105 29.484 T 13-10-2018 IPR026660 Phosphoribosyl-AMP cyclohydrolase GO:0000105|GO:0004635 KEGG: 00340+3.5.4.19 TOPB45_0585 6c7d242fbaf9f6f6ed97eb1a14545688 126 Gene3D G3DSA:3.10.20.400 1 92 3.1E-37 T 13-10-2018 IPR038019 Phosphoribosyl-AMP cyclohydrolase domain superfamily KEGG: 00340+3.5.4.19 TOPB45_0553 a1939b97c6dec52e5a3e40b67dd6c3ec 168 Gene3D G3DSA:3.30.460.40 3 158 1.7E-22 T 13-10-2018 TOPB45_0553 a1939b97c6dec52e5a3e40b67dd6c3ec 168 Pfam PF08843 Nucleotidyl transferase AbiEii toxin, Type IV TA system 28 105 1.6E-4 T 13-10-2018 IPR014942 Nucleotidyl transferase AbiEii toxin, Type IV TA system TOPB45_0553 a1939b97c6dec52e5a3e40b67dd6c3ec 168 SUPERFAMILY SSF81301 8 153 2.03E-17 T 13-10-2018 TOPB45_1234 7d7c2bad6e8a9ae274e8bb95beeba8c7 381 PIRSF PIRSF004810 1 380 1.0E-98 T 13-10-2018 IPR014047 Chromate transporter, long chain TOPB45_1234 7d7c2bad6e8a9ae274e8bb95beeba8c7 381 Pfam PF02417 Chromate transporter 215 375 1.2E-36 T 13-10-2018 IPR003370 Chromate transporter GO:0015109|GO:0015703 TOPB45_1234 7d7c2bad6e8a9ae274e8bb95beeba8c7 381 Pfam PF02417 Chromate transporter 8 168 2.5E-35 T 13-10-2018 IPR003370 Chromate transporter GO:0015109|GO:0015703 TOPB45_1234 7d7c2bad6e8a9ae274e8bb95beeba8c7 381 TIGRFAM TIGR00937 2A51: chromate efflux transporter 13 375 3.8E-100 T 13-10-2018 IPR014047 Chromate transporter, long chain TOPB45_1055 24a721761c1d791031060b0e27cd0be1 328 Pfam PF01939 Endonuclease NucS 27 98 1.6E-7 T 13-10-2018 IPR002793 Endonuclease NucS GO:0004519 TOPB45_1055 24a721761c1d791031060b0e27cd0be1 328 Gene3D G3DSA:3.40.1350.10 23 127 1.0E-14 T 13-10-2018 IPR011856 tRNA endonuclease-like domain superfamily GO:0003676|GO:0004518 TOPB45_1136 8dda9d58130ef60b9d31ab0aed1819fa 268 Pfam PF01061 ABC-2 type transporter 32 223 2.9E-10 T 13-10-2018 IPR013525 ABC-2 type transporter GO:0016020 Reactome: R-HSA-1369062 TOPB45_0686 86a3fa73486a5fa205bb0ff100450b80 163 Pfam PF07813 LTXXQ motif family protein 59 152 2.2E-7 T 13-10-2018 IPR012899 LTXXQ motif family protein GO:0042597 TOPB45_0686 86a3fa73486a5fa205bb0ff100450b80 163 Gene3D G3DSA:1.20.120.1490 56 161 2.2E-13 T 13-10-2018 TOPB45_1381 63cbf25705b21efacd1f4b58f83ae517 100 SMART SM00507 26 77 3.4E-12 T 13-10-2018 IPR003615 HNH nuclease TOPB45_1381 63cbf25705b21efacd1f4b58f83ae517 100 Pfam PF14279 HNH endonuclease 37 82 4.7E-15 T 13-10-2018 IPR029471 HNH endonuclease 5 TOPB45_1381 63cbf25705b21efacd1f4b58f83ae517 100 Gene3D G3DSA:3.30.40.60 2 100 5.7E-36 T 13-10-2018 TOPB45_1313 f6cabe323d645d98f632c902368f9e44 198 Pfam PF01891 Cobalt uptake substrate-specific transmembrane region 2 195 2.1E-54 T 13-10-2018 IPR002751 Metal transport protein CbiM/NikMN GO:0000041|GO:0016021 TOPB45_1313 f6cabe323d645d98f632c902368f9e44 198 Gene3D G3DSA:1.10.1760.20 1 196 1.7E-45 T 13-10-2018 TOPB45_0107 3380c628ff6ac1b2e1f9dde6be536cc4 119 Pfam PF04977 Septum formation initiator 32 104 2.8E-8 T 13-10-2018 IPR007060 Septum formation initiator FtsL/DivIC TOPB45_1262 a9cf60c76a12e28eb5127e29cb2dbebe 436 Pfam PF03349 Outer membrane protein transport protein (OMPP1/FadL/TodX) 15 436 3.1E-116 T 13-10-2018 IPR005017 Outer membrane protein transport protein (OMPP1/FadL/TodX) TOPB45_1262 a9cf60c76a12e28eb5127e29cb2dbebe 436 SUPERFAMILY SSF56935 23 436 1.79E-92 T 13-10-2018 TOPB45_1262 a9cf60c76a12e28eb5127e29cb2dbebe 436 Gene3D G3DSA:2.40.160.60 23 436 1.2E-144 T 13-10-2018 TOPB45_0199 40d47eb6add5401ccc76f73b830fda3c 122 Pfam PF11839 Alanine-zipper, major outer membrane lipoprotein 58 122 6.4E-10 T 13-10-2018 IPR021793 Major outer membrane lipoprotein Oprl TOPB45_0366 afe3b5652e6087acc97f7af82e551153 222 Pfam PF04250 Protein of unknown function (DUF429) 6 193 2.5E-7 T 13-10-2018 IPR007362 Protein of unknown function DUF429 TOPB45_1609 bd85ba9ba6bb7468864a614af834fa07 216 TIGRFAM TIGR00057 TIGR00057: tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family 18 210 1.9E-49 T 13-10-2018 IPR006070 YrdC-like domain GO:0003725 TOPB45_1609 bd85ba9ba6bb7468864a614af834fa07 216 Pfam PF01300 Telomere recombination 25 199 7.6E-49 T 13-10-2018 IPR006070 YrdC-like domain GO:0003725 TOPB45_1609 bd85ba9ba6bb7468864a614af834fa07 216 Gene3D G3DSA:3.90.870.10 4 213 4.1E-62 T 13-10-2018 TOPB45_1609 bd85ba9ba6bb7468864a614af834fa07 216 SUPERFAMILY SSF55821 19 209 7.63E-56 T 13-10-2018 IPR017945 DHBP synthase RibB-like alpha/beta domain superfamily TOPB45_0419 1407275742050cfe328fc48ee2800b6f 380 Pfam PF00149 Calcineurin-like phosphoesterase 148 312 8.0E-14 T 13-10-2018 IPR004843 Calcineurin-like phosphoesterase domain, ApaH type GO:0016787 TOPB45_0419 1407275742050cfe328fc48ee2800b6f 380 Gene3D G3DSA:3.60.21.10 146 343 8.8E-23 T 13-10-2018 IPR029052 Metallo-dependent phosphatase-like TOPB45_0419 1407275742050cfe328fc48ee2800b6f 380 SUPERFAMILY SSF56300 148 369 2.44E-33 T 13-10-2018 TOPB45_0938 1e352be89ad3322cfe9467efc1f723b4 333 SUPERFAMILY SSF56519 37 154 2.49E-10 T 13-10-2018 IPR036138 Penicillin-binding protein, dimerisation domain superfamily GO:0008658 TOPB45_0938 1e352be89ad3322cfe9467efc1f723b4 333 Gene3D G3DSA:3.90.1310.30 32 176 5.0E-8 T 13-10-2018 TOPB45_0682 dfc116d09486c9893363cf14ee8ff8c2 139 Pfam PF13441 YMGG-like Gly-zipper 34 77 3.8E-11 T 13-10-2018 IPR027367 YMGG-like Gly-zipper TOPB45_0089 9f298077dfde0c12ef1112030017099d 536 Pfam PF02120 Flagellar hook-length control protein FliK 412 484 4.7E-12 T 13-10-2018 IPR021136 Flagellar hook-length control protein-like, C-terminal TOPB45_0089 9f298077dfde0c12ef1112030017099d 536 Gene3D G3DSA:3.30.750.140 393 498 9.7E-8 T 13-10-2018 IPR038610 FliK-like, C-terminal domain superfamily TOPB45_1549 6eb57f4070513ac67c1fd7b2bbce47fe 182 PRINTS PR00125 ATP synthase delta subunit signature 152 170 4.0E-22 T 13-10-2018 IPR000711 ATPase, OSCP/delta subunit GO:0015986|GO:0046933 Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_1549 6eb57f4070513ac67c1fd7b2bbce47fe 182 PRINTS PR00125 ATP synthase delta subunit signature 87 101 4.0E-22 T 13-10-2018 IPR000711 ATPase, OSCP/delta subunit GO:0015986|GO:0046933 Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_1549 6eb57f4070513ac67c1fd7b2bbce47fe 182 PRINTS PR00125 ATP synthase delta subunit signature 6 25 4.0E-22 T 13-10-2018 IPR000711 ATPase, OSCP/delta subunit GO:0015986|GO:0046933 Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_1549 6eb57f4070513ac67c1fd7b2bbce47fe 182 PRINTS PR00125 ATP synthase delta subunit signature 137 152 4.0E-22 T 13-10-2018 IPR000711 ATPase, OSCP/delta subunit GO:0015986|GO:0046933 Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_1549 6eb57f4070513ac67c1fd7b2bbce47fe 182 PRINTS PR00125 ATP synthase delta subunit signature 76 87 4.0E-22 T 13-10-2018 IPR000711 ATPase, OSCP/delta subunit GO:0015986|GO:0046933 Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_1549 6eb57f4070513ac67c1fd7b2bbce47fe 182 TIGRFAM TIGR01145 ATP_synt_delta: ATP synthase F1, delta subunit 6 174 8.0E-35 T 13-10-2018 IPR000711 ATPase, OSCP/delta subunit GO:0015986|GO:0046933 Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_1549 6eb57f4070513ac67c1fd7b2bbce47fe 182 Pfam PF00213 ATP synthase delta (OSCP) subunit 6 175 1.6E-43 T 13-10-2018 IPR000711 ATPase, OSCP/delta subunit GO:0015986|GO:0046933 Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_1549 6eb57f4070513ac67c1fd7b2bbce47fe 182 SUPERFAMILY SSF47928 4 105 5.1E-18 T 13-10-2018 IPR026015 F1F0 ATP synthase OSCP/delta subunit, N-terminal domain superfamily Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_1549 6eb57f4070513ac67c1fd7b2bbce47fe 182 Gene3D G3DSA:1.10.520.20 6 100 2.7E-11 T 13-10-2018 IPR026015 F1F0 ATP synthase OSCP/delta subunit, N-terminal domain superfamily Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_1549 6eb57f4070513ac67c1fd7b2bbce47fe 182 Hamap MF_01416 ATP synthase subunit delta [atpD]. 2 179 19.155 T 13-10-2018 IPR000711 ATPase, OSCP/delta subunit GO:0015986|GO:0046933 Reactome: R-HSA-163210|Reactome: R-HSA-8949613 TOPB45_0456 638df1166049581bcb52019f9b9122ae 462 SUPERFAMILY SSF56935 143 462 1.86E-8 T 13-10-2018 TOPB45_0720 277b6f8c87d33865d94f0f5b47f0a307 169 Pfam PF02674 Colicin V production protein 4 143 8.9E-22 T 13-10-2018 IPR003825 Colicin V production, CvpA GO:0009403|GO:0016020 TOPB45_1171 211891da72e87890308edfda31f41c0e 93 Pfam PF04025 Domain of unknown function (DUF370) 7 79 1.1E-36 T 13-10-2018 IPR007169 Extracellular matrix regulatory protein A TOPB45_1171 211891da72e87890308edfda31f41c0e 93 Hamap MF_01503 UPF0296 protein . 5 93 27.845 T 13-10-2018 IPR007169 Extracellular matrix regulatory protein A TOPB45_1171 211891da72e87890308edfda31f41c0e 93 ProDom PD063023 UPF0296 YLZA BA4010/GBAA4010/BAS3723 BLI01788/BL02292 BT9727_3613 BC3870 TM1690 CBDBA43 SYC0519_C BCE33L3631 7 78 1.0E-27 T 13-10-2018 IPR007169 Extracellular matrix regulatory protein A TOPB45_0280 2aa507f9fc101123210f3920444f83e4 399 Gene3D G3DSA:3.20.110.20 1 384 1.2E-23 T 13-10-2018 TOPB45_0280 2aa507f9fc101123210f3920444f83e4 399 Pfam PF03065 Glycosyl hydrolase family 57 7 326 6.5E-46 T 13-10-2018 IPR004300 Glycoside hydrolase family 57, N-terminal domain GO:0003824|GO:0005975 TOPB45_0280 2aa507f9fc101123210f3920444f83e4 399 SUPERFAMILY SSF88713 2 333 1.59E-49 T 13-10-2018 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 TOPB45_0369 0afa8d12206ca10ab6e2ee798729754e 165 TIGRFAM TIGR01498 folK: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase 10 140 4.7E-39 T 13-10-2018 IPR000550 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK GO:0003848|GO:0009396 KEGG: 00790+2.7.6.3|MetaCyc: PWY-6147|MetaCyc: PWY-6148|MetaCyc: PWY-6797|MetaCyc: PWY-7539|MetaCyc: PWY-7852|MetaCyc: PWY-7853 TOPB45_0369 0afa8d12206ca10ab6e2ee798729754e 165 SUPERFAMILY SSF55083 8 159 2.22E-47 T 13-10-2018 IPR035907 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK superfamily KEGG: 00790+2.7.6.3|MetaCyc: PWY-6147|MetaCyc: PWY-6148|MetaCyc: PWY-6797|MetaCyc: PWY-7539|MetaCyc: PWY-7852|MetaCyc: PWY-7853 TOPB45_0369 0afa8d12206ca10ab6e2ee798729754e 165 Pfam PF01288 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) 12 140 6.7E-36 T 13-10-2018 IPR000550 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK GO:0003848|GO:0009396 KEGG: 00790+2.7.6.3|MetaCyc: PWY-6147|MetaCyc: PWY-6148|MetaCyc: PWY-6797|MetaCyc: PWY-7539|MetaCyc: PWY-7852|MetaCyc: PWY-7853 TOPB45_0369 0afa8d12206ca10ab6e2ee798729754e 165 Gene3D G3DSA:3.30.70.560 5 164 7.7E-52 T 13-10-2018 IPR035907 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK superfamily KEGG: 00790+2.7.6.3|MetaCyc: PWY-6147|MetaCyc: PWY-6148|MetaCyc: PWY-6797|MetaCyc: PWY-7539|MetaCyc: PWY-7852|MetaCyc: PWY-7853 TOPB45_0111 2bb657574f428ddcf074116951d333a6 999 SUPERFAMILY SSF52540 22 983 2.15E-17 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0111 2bb657574f428ddcf074116951d333a6 999 Gene3D G3DSA:3.40.50.300 1 292 4.2E-36 T 13-10-2018 TOPB45_0111 2bb657574f428ddcf074116951d333a6 999 Gene3D G3DSA:3.40.50.300 759 997 3.9E-24 T 13-10-2018 TOPB45_0111 2bb657574f428ddcf074116951d333a6 999 SUPERFAMILY SSF52540 714 986 1.37E-17 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_0111 2bb657574f428ddcf074116951d333a6 999 Pfam PF13476 AAA domain 6 233 3.1E-21 T 13-10-2018 IPR038729 Rad50/SbcC-type AAA domain TOPB45_0111 2bb657574f428ddcf074116951d333a6 999 Pfam PF13558 Putative exonuclease SbcCD, C subunit 890 953 1.0E-9 T 13-10-2018 TOPB45_0149 5754c3d1871a2d7d86c95a9e160cc47a 98 Gene3D G3DSA:3.30.460.10 6 98 3.3E-21 T 13-10-2018 TOPB45_0149 5754c3d1871a2d7d86c95a9e160cc47a 98 Pfam PF01909 Nucleotidyltransferase domain 12 92 1.5E-9 T 13-10-2018 IPR002934 Polymerase, nucleotidyl transferase domain GO:0016779 TOPB45_0149 5754c3d1871a2d7d86c95a9e160cc47a 98 SUPERFAMILY SSF81301 8 96 5.32E-17 T 13-10-2018 TOPB45_0789 6851dacb187407f96dbb0b3170306ce9 157 SUPERFAMILY SSF46785 4 64 5.01E-7 T 13-10-2018 IPR036390 Winged helix DNA-binding domain superfamily TOPB45_0789 6851dacb187407f96dbb0b3170306ce9 157 Gene3D G3DSA:3.30.70.3460 27 157 1.5E-38 T 13-10-2018 TOPB45_0912 3c1adb3b6e6f6ab56a7adfaf5aca0336 137 Pfam PF10627 Curli assembly protein CsgE 38 128 8.4E-25 T 13-10-2018 IPR018900 Curli assembly protein CsgE TOPB45_0612 24fcea6cc9ab193c3d06ceedaa8e2bc8 580 Pfam PF03600 Citrate transporter 155 523 3.2E-50 T 13-10-2018 IPR004680 Citrate transporter-like domain GO:0016021|GO:0055085 Reactome: R-HSA-5662702 TOPB45_0612 24fcea6cc9ab193c3d06ceedaa8e2bc8 580 PRINTS PR00758 Arsenical pump membrane protein signature 251 275 2.7E-6 T 13-10-2018 IPR000802 Arsenical pump membrane protein, ArsB GO:0015105|GO:0015700|GO:0016021 TOPB45_0612 24fcea6cc9ab193c3d06ceedaa8e2bc8 580 PRINTS PR00758 Arsenical pump membrane protein signature 369 394 2.7E-6 T 13-10-2018 IPR000802 Arsenical pump membrane protein, ArsB GO:0015105|GO:0015700|GO:0016021 TOPB45_0612 24fcea6cc9ab193c3d06ceedaa8e2bc8 580 PRINTS PR00758 Arsenical pump membrane protein signature 431 455 2.7E-6 T 13-10-2018 IPR000802 Arsenical pump membrane protein, ArsB GO:0015105|GO:0015700|GO:0016021 TOPB45_0612 24fcea6cc9ab193c3d06ceedaa8e2bc8 580 PRINTS PR00758 Arsenical pump membrane protein signature 519 544 2.7E-6 T 13-10-2018 IPR000802 Arsenical pump membrane protein, ArsB GO:0015105|GO:0015700|GO:0016021 TOPB45_1253 0de1eaac7e8c3fd00a1f110e44975448 117 Gene3D G3DSA:3.20.20.70 6 116 6.0E-12 T 13-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 TOPB45_1253 0de1eaac7e8c3fd00a1f110e44975448 117 SUPERFAMILY SSF102114 14 114 1.96E-11 T 13-10-2018 TOPB45_1253 0de1eaac7e8c3fd00a1f110e44975448 117 Pfam PF13353 4Fe-4S single cluster domain 37 107 8.8E-5 T 13-10-2018 TOPB45_0402 68a10c5904925b4b7b25418f6fd1fd84 559 TIGRFAM TIGR00644 recJ: single-stranded-DNA-specific exonuclease RecJ 28 530 8.1E-135 T 13-10-2018 IPR004610 Bacterial RecJ exonuclease GO:0006281|GO:0006310|GO:0008409 TOPB45_0402 68a10c5904925b4b7b25418f6fd1fd84 559 Pfam PF01368 DHH family 81 206 3.0E-9 T 13-10-2018 IPR001667 DDH domain KEGG: 00190+3.6.1.1|MetaCyc: PWY-7805|MetaCyc: PWY-7807 TOPB45_0402 68a10c5904925b4b7b25418f6fd1fd84 559 Gene3D G3DSA:2.40.50.460 446 559 9.1E-7 T 13-10-2018 TOPB45_0402 68a10c5904925b4b7b25418f6fd1fd84 559 Gene3D G3DSA:3.10.310.30 328 445 4.4E-25 T 13-10-2018 TOPB45_0402 68a10c5904925b4b7b25418f6fd1fd84 559 Gene3D G3DSA:3.90.1640.30 56 327 5.6E-70 T 13-10-2018 TOPB45_0402 68a10c5904925b4b7b25418f6fd1fd84 559 SUPERFAMILY SSF64182 57 447 9.81E-89 T 13-10-2018 IPR038763 DHH phosphoesterase superfamily TOPB45_0402 68a10c5904925b4b7b25418f6fd1fd84 559 Pfam PF02272 DHHA1 domain 324 444 1.3E-13 T 13-10-2018 IPR003156 DHHA1 domain GO:0003676 KEGG: 00970+6.1.1.7|Reactome: R-HSA-379716 TOPB45_1151 f84326160c49dedc54c861fa2a58bf7a 368 Gene3D G3DSA:3.80.30.30 109 330 1.4E-54 T 13-10-2018 TOPB45_1160 ec672211e523b87c23e6bad3599ab174 225 Pfam PF09568 MjaI restriction endonuclease 4 188 6.6E-64 T 13-10-2018 IPR019068 Restriction endonuclease, type II, MjaI GO:0003677|GO:0009036|GO:0009307 TOPB45_1189 e279447b5c21cf0dbd3ac17568c42dae 177 Pfam PF14385 Domain of unknown function (DUF4416) 11 170 2.1E-57 T 13-10-2018 IPR025529 Protein of unknown function DUF4416 TOPB45_1339 cd8e59cc4cf312157ff47aecc8317c52 178 Gene3D G3DSA:3.40.220.10 1 176 2.0E-67 T 13-10-2018 TOPB45_1339 cd8e59cc4cf312157ff47aecc8317c52 178 SUPERFAMILY SSF52949 3 176 2.86E-62 T 13-10-2018 TOPB45_1339 cd8e59cc4cf312157ff47aecc8317c52 178 SMART SM00506 10 140 3.0E-46 T 13-10-2018 IPR002589 Macro domain TOPB45_1339 cd8e59cc4cf312157ff47aecc8317c52 178 Pfam PF01661 Macro domain 27 140 1.2E-39 T 13-10-2018 IPR002589 Macro domain TOPB45_0322 43d5028d046500d9a65bfc37547da673 99 Gene3D G3DSA:3.30.460.10 1 99 1.4E-13 T 13-10-2018 TOPB45_0322 43d5028d046500d9a65bfc37547da673 99 Pfam PF01909 Nucleotidyltransferase domain 14 78 5.6E-5 T 13-10-2018 IPR002934 Polymerase, nucleotidyl transferase domain GO:0016779 TOPB45_0322 43d5028d046500d9a65bfc37547da673 99 SUPERFAMILY SSF81301 10 97 3.78E-9 T 13-10-2018 TOPB45_0882 a80f1a7a5a723e207232fc7f0afd882c 198 Pfam PF01066 CDP-alcohol phosphatidyltransferase 31 94 2.4E-11 T 13-10-2018 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 TOPB45_0882 a80f1a7a5a723e207232fc7f0afd882c 198 ProSitePatterns PS00379 CDP-alcohol phosphatidyltransferases signature. 72 94 - T 13-10-2018 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 TOPB45_0882 a80f1a7a5a723e207232fc7f0afd882c 198 Gene3D G3DSA:1.20.120.1760 11 196 1.6E-56 T 13-10-2018 TOPB45_1196 9fdb6c1986f1b98ffc86a0752ddaeb43 150 Hamap MF_00440 Transcriptional repressor NrdR [nrdR]. 1 150 79.296 T 13-10-2018 IPR003796 Ribonucleotide reductase regulator NrdR-like GO:0008270|GO:0045892 TOPB45_1196 9fdb6c1986f1b98ffc86a0752ddaeb43 150 Pfam PF03477 ATP cone domain 48 135 3.1E-19 T 13-10-2018 IPR005144 ATP-cone domain Reactome: R-HSA-499943 TOPB45_1196 9fdb6c1986f1b98ffc86a0752ddaeb43 150 TIGRFAM TIGR00244 TIGR00244: transcriptional regulator NrdR 1 146 2.8E-59 T 13-10-2018 IPR003796 Ribonucleotide reductase regulator NrdR-like GO:0008270|GO:0045892 TOPB45_1590 3b944c6ae452258259912e8daddb0f1c 280 SMART SM00481 2 67 3.7E-18 T 13-10-2018 IPR003141 Polymerase/histidinol phosphatase, N-terminal TOPB45_1590 3b944c6ae452258259912e8daddb0f1c 280 Pfam PF02811 PHP domain 3 160 4.7E-13 T 13-10-2018 IPR004013 PHP domain GO:0003824 TOPB45_1590 3b944c6ae452258259912e8daddb0f1c 280 Gene3D G3DSA:3.20.20.140 2 247 3.3E-88 T 13-10-2018 TOPB45_1590 3b944c6ae452258259912e8daddb0f1c 280 SUPERFAMILY SSF89550 2 254 9.81E-47 T 13-10-2018 IPR016195 Polymerase/histidinol phosphatase-like GO:0003824 Reactome: R-HSA-6784531|Reactome: R-HSA-6791226 TOPB45_1590 3b944c6ae452258259912e8daddb0f1c 280 Gene3D G3DSA:1.10.150.650 96 166 3.3E-88 T 13-10-2018 TOPB45_0744 bab64d3556c1959bad1a20b0dd9cce43 306 SUPERFAMILY SSF53448 2 262 8.84E-36 T 13-10-2018 IPR029044 Nucleotide-diphospho-sugar transferases TOPB45_0744 bab64d3556c1959bad1a20b0dd9cce43 306 Gene3D G3DSA:3.90.550.10 1 225 1.3E-36 T 13-10-2018 IPR029044 Nucleotide-diphospho-sugar transferases TOPB45_0744 bab64d3556c1959bad1a20b0dd9cce43 306 Pfam PF00535 Glycosyl transferase family 2 5 140 1.0E-29 T 13-10-2018 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 TOPB45_0143 69d1a6c5c5b6008e331ff76d93b5b177 67 Gene3D G3DSA:3.40.50.150 14 61 2.6E-7 T 13-10-2018 TOPB45_0143 69d1a6c5c5b6008e331ff76d93b5b177 67 SUPERFAMILY SSF53335 21 57 4.71E-9 T 13-10-2018 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase TOPB45_0032 dee13ca951ec94e1bf5393c1335c16fe 150 Gene3D G3DSA:3.30.70.3460 68 135 1.8E-23 T 13-10-2018 TOPB45_0032 dee13ca951ec94e1bf5393c1335c16fe 150 Gene3D G3DSA:1.10.10.2890 10 67 1.8E-23 T 13-10-2018 TOPB45_1204 3f1c8c91c99c475919fc43510ac1391a 396 Pfam PF03916 Polysulphide reductase, NrfD 41 322 1.7E-39 T 13-10-2018 IPR005614 NrfD family TOPB45_1067 1b683640b0378047da2cb7578b3953ac 403 Pfam PF02687 FtsX-like permease family 307 395 3.0E-14 T 13-10-2018 IPR003838 ABC transporter permease protein domain GO:0016020 TOPB45_1067 1b683640b0378047da2cb7578b3953ac 403 Pfam PF12704 MacB-like periplasmic core domain 20 242 5.3E-29 T 13-10-2018 IPR025857 MacB-like periplasmic core domain TOPB45_1026 502567227db48ccbf67e4d59aa852cbf 89 Pfam PF11154 Protein of unknown function (DUF2934) 6 41 1.9E-12 T 13-10-2018 IPR021327 Protein of unknown function DUF2934 TOPB45_0277 98c0289d2f0cf1c9bb0803fefdd0eb54 107 SUPERFAMILY SSF58113 31 102 5.75E-5 T 13-10-2018 TOPB45_0277 98c0289d2f0cf1c9bb0803fefdd0eb54 107 Gene3D G3DSA:1.20.120.20 25 106 6.6E-6 T 13-10-2018 TOPB45_0277 98c0289d2f0cf1c9bb0803fefdd0eb54 107 Pfam PF12732 YtxH-like protein 8 93 3.5E-15 T 13-10-2018 IPR024623 Uncharacterised protein family YtxH TOPB45_0889 9e3c01709975c122e3d537f80f6bbe5e 351 Pfam PF03773 Predicted permease 8 345 1.8E-75 T 13-10-2018 IPR005524 Predicted permease DUF318 TOPB45_1072 a0484b77b003fe3f0871106d790ed29b 461 Pfam PF13520 Amino acid permease 24 427 2.5E-53 T 13-10-2018 IPR002293 Amino acid/polyamine transporter I GO:0016020|GO:0022857|GO:0055085 TOPB45_1072 a0484b77b003fe3f0871106d790ed29b 461 PIRSF PIRSF006060 10 460 7.0E-84 T 13-10-2018 IPR002293 Amino acid/polyamine transporter I GO:0016020|GO:0022857|GO:0055085 TOPB45_1072 a0484b77b003fe3f0871106d790ed29b 461 Gene3D G3DSA:1.20.1740.10 17 458 8.4E-115 T 13-10-2018 TOPB45_0404 52923a81b32f0815372921c32cd8e3d2 267 Pfam PF00551 Formyl transferase 86 172 1.0E-9 T 13-10-2018 IPR002376 Formyl transferase, N-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 TOPB45_0404 52923a81b32f0815372921c32cd8e3d2 267 SUPERFAMILY SSF53328 5 180 2.88E-17 T 13-10-2018 IPR036477 Formyl transferase, N-terminal domain superfamily GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 TOPB45_0404 52923a81b32f0815372921c32cd8e3d2 267 Gene3D G3DSA:3.40.50.170 6 230 1.4E-24 T 13-10-2018 TOPB45_0233 b0d1b0e7553b22c4d96c19f4a7aee9f7 237 SUPERFAMILY SSF49265 98 180 6.49E-8 T 13-10-2018 IPR036116 Fibronectin type III superfamily GO:0005515 TOPB45_0324 a7eb631ce2eba1bb0c5a0d0e34a50c57 308 Pfam PF13173 AAA domain 3 41 8.9E-8 T 13-10-2018 TOPB45_0324 a7eb631ce2eba1bb0c5a0d0e34a50c57 308 Pfam PF13635 Domain of unknown function (DUF4143) 119 256 6.0E-21 T 13-10-2018 IPR025420 Domain of unknown function DUF4143 TOPB45_1588 921873b5c871a74995281284a927df5f 80 Pfam PF10865 Domain of unknown function (DUF2703) 4 46 5.8E-8 T 13-10-2018 IPR021219 Protein of unknown function DUF2703 TOPB45_0147 89e0ff923fe6ab7cf0a9c2bb159df77a 195 Pfam PF08937 MTH538 TIR-like domain (DUF1863) 3 110 3.1E-30 T 13-10-2018 IPR015032 MTH538 TIR-like domain TOPB45_0147 89e0ff923fe6ab7cf0a9c2bb159df77a 195 SUPERFAMILY SSF52206 41 103 6.28E-11 T 13-10-2018 IPR036490 Hypothetical protein MTH538 superfamily TOPB45_0489 e42c6e331e0fe17056c3cdc94119619e 472 Pfam PF13231 Dolichyl-phosphate-mannose-protein mannosyltransferase 51 209 3.5E-31 T 13-10-2018 IPR038731 Glycosyltransferase RgtA/B/C/D-like TOPB45_0735 51deeca1ae02150814a42adf4e9168f3 245 PIRSF PIRSF006648 3 245 2.5E-31 T 13-10-2018 IPR000412 ABC-2 transporter GO:0016021|GO:0043190|GO:0055085 TOPB45_0735 51deeca1ae02150814a42adf4e9168f3 245 Pfam PF01061 ABC-2 type transporter 15 211 2.7E-21 T 13-10-2018 IPR013525 ABC-2 type transporter GO:0016020 Reactome: R-HSA-1369062 TOPB45_0735 51deeca1ae02150814a42adf4e9168f3 245 PRINTS PR00164 ABC-2 type transport system membrane protein signature 171 190 8.4E-15 T 13-10-2018 IPR000412 ABC-2 transporter GO:0016021|GO:0043190|GO:0055085 TOPB45_0735 51deeca1ae02150814a42adf4e9168f3 245 PRINTS PR00164 ABC-2 type transport system membrane protein signature 191 210 8.4E-15 T 13-10-2018 IPR000412 ABC-2 transporter GO:0016021|GO:0043190|GO:0055085 TOPB45_0735 51deeca1ae02150814a42adf4e9168f3 245 PRINTS PR00164 ABC-2 type transport system membrane protein signature 134 158 8.4E-15 T 13-10-2018 IPR000412 ABC-2 transporter GO:0016021|GO:0043190|GO:0055085 TOPB45_0735 51deeca1ae02150814a42adf4e9168f3 245 PRINTS PR00164 ABC-2 type transport system membrane protein signature 98 123 8.4E-15 T 13-10-2018 IPR000412 ABC-2 transporter GO:0016021|GO:0043190|GO:0055085 TOPB45_0735 51deeca1ae02150814a42adf4e9168f3 245 PRINTS PR00164 ABC-2 type transport system membrane protein signature 24 45 8.4E-15 T 13-10-2018 IPR000412 ABC-2 transporter GO:0016021|GO:0043190|GO:0055085 TOPB45_1198 a94765b17dfcb4884ad2c5709673b437 361 Pfam PF05559 Protein of unknown function (DUF763) 6 321 1.1E-122 T 13-10-2018 IPR008482 Protein of unknown function DUF763 TOPB45_1603 0f9e7bd3994f77cbbc75a2bf6f5cf1fa 237 Gene3D G3DSA:3.40.50.300 1 182 6.4E-28 T 13-10-2018 TOPB45_1603 0f9e7bd3994f77cbbc75a2bf6f5cf1fa 237 SUPERFAMILY SSF52540 2 122 2.23E-10 T 13-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase TOPB45_1603 0f9e7bd3994f77cbbc75a2bf6f5cf1fa 237 Pfam PF03205 Molybdopterin guanine dinucleotide synthesis protein B 5 139 5.8E-17 T 13-10-2018 IPR004435 Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB) domain GO:0005525|GO:0006777 TOPB45_0093 064ff752e3e41743d82796af8c4f327f 100 Hamap MF_01456 NAD(P)H-quinone oxidoreductase subunit 4L, chloroplastic [ndhE]. 2 100 18.211 T 13-10-2018 IPR001133 NADH-ubiquinone oxidoreductase chain 4L/K GO:0016651|GO:0042773|GO:0055114 TOPB45_0093 064ff752e3e41743d82796af8c4f327f 100 Pfam PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 7 95 1.6E-21 T 13-10-2018 IPR039428 NADH-ubiquinone oxidoreductase chain 4L/Mnh complex subunit C1-like TOPB45_0514 46a362a694654ca5e453ea8bf30a3727 537 Pfam PF13231 Dolichyl-phosphate-mannose-protein mannosyltransferase 60 230 2.0E-13 T 13-10-2018 IPR038731 Glycosyltransferase RgtA/B/C/D-like TOPB45_0504 9b787ee8a6439ea2af15076e4de7ecec 210 Pfam PF14281 PD-(D/E)XK nuclease superfamily 58 174 2.9E-5 T 13-10-2018 IPR029470 PD-(D/E)XK nuclease superfamily 4 TOPB45_1420 2963459f721116175e171e2f9330d1d4 105 Pfam PF02579 Dinitrogenase iron-molybdenum cofactor 13 100 2.8E-21 T 13-10-2018 IPR003731 Dinitrogenase iron-molybdenum cofactor biosynthesis TOPB45_1420 2963459f721116175e171e2f9330d1d4 105 SUPERFAMILY SSF53146 1 95 2.49E-26 T 13-10-2018 IPR036105 Dinitrogenase iron-molybdenum cofactor biosynthesis superfamily TOPB45_1420 2963459f721116175e171e2f9330d1d4 105 Gene3D G3DSA:3.30.420.130 1 105 1.4E-30 T 13-10-2018 IPR036105 Dinitrogenase iron-molybdenum cofactor biosynthesis superfamily TOPB45_1054 c7248c4cfbf7317828f9a39e5c803717 83 Pfam PF02742 Iron dependent repressor, metal binding and dimerisation domain 52 80 2.2E-4 T 13-10-2018 IPR001367 Iron dependent repressor, metal binding and dimerisation domain GO:0046914|GO:0046983 TOPB45_0911 f60892540f4e3adea9dec076cc460881 123 Gene3D G3DSA:2.60.40.2420 23 122 6.8E-6 T 13-10-2018 TOPB45_1367 9edf6a3b0ab5c01338c5621e5351bf9d 206 Pfam PF07949 YbbR-like protein 37 117 5.0E-5 T 13-10-2018 IPR012505 YbbR-like TOPB45_1367 9edf6a3b0ab5c01338c5621e5351bf9d 206 Gene3D G3DSA:2.170.120.30 30 129 1.2E-14 T 13-10-2018 TOPB45_0925 f1ac9f58d77acb6156958be4772948c0 280 SUPERFAMILY SSF54523 9 99 3.77E-7 T 13-10-2018 TOPB45_1009 8447ef8c25dabacaed2cee2455bddcd9 147 SUPERFAMILY SSF49764 9 145 2.36E-46 T 13-10-2018 IPR008978 HSP20-like chaperone TOPB45_1009 8447ef8c25dabacaed2cee2455bddcd9 147 Gene3D G3DSA:2.60.40.790 4 146 1.1E-45 T 13-10-2018 IPR008978 HSP20-like chaperone TOPB45_1009 8447ef8c25dabacaed2cee2455bddcd9 147 Pfam PF00011 Hsp20/alpha crystallin family 44 145 2.7E-29 T 13-10-2018 IPR002068 Alpha crystallin/Hsp20 domain TOPB45_1552 3bb0ddeaff97c2e8fd20cede4f7fe4dd 361 Pfam PF01098 Cell cycle protein 19 356 4.6E-65 T 13-10-2018 IPR001182 Probable peptidoglycan glycosyltransferase FtsW/RodA GO:0016021|GO:0051301 KEGG: 00550+2.4.1.129|MetaCyc: PWY-5265|MetaCyc: PWY-6385|MetaCyc: PWY-6470|MetaCyc: PWY-6471 TOPB45_1306 b7b4092f4f024654e197752e40b30ed8 555 SUPERFAMILY SSF69318 228 482 1.7E-13 T 13-10-2018 TOPB45_0455 175bfbc9ae7e061ab06fee9254fe3c17 305 Gene3D G3DSA:1.10.287.110 239 304 3.3E-10 T 13-10-2018 IPR036869 Chaperone J-domain superfamily TOPB45_0455 175bfbc9ae7e061ab06fee9254fe3c17 305 SUPERFAMILY SSF46565 245 299 1.44E-9 T 13-10-2018 IPR036869 Chaperone J-domain superfamily TOPB45_0455 175bfbc9ae7e061ab06fee9254fe3c17 305 SMART SM00271 245 303 1.8E-7 T 13-10-2018 IPR001623 DnaJ domain TOPB45_1108 1aa74fd463117c8f77c94a5b771c8b3a 490 Gene3D G3DSA:3.30.230.10 106 216 1.6E-5 T 13-10-2018 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup TOPB45_1108 1aa74fd463117c8f77c94a5b771c8b3a 490 SUPERFAMILY SSF54211 135 194 2.84E-5 T 13-10-2018 IPR020568 Ribosomal protein S5 domain 2-type fold TOPB45_1494 b0f60de57fc6d705b87d4411d3cf9536 223 SUPERFAMILY SSF103501 9 212 2.35E-28 T 13-10-2018 IPR036197 NarG-like superfamily TOPB45_1494 b0f60de57fc6d705b87d4411d3cf9536 223 Pfam PF02665 Nitrate reductase gamma subunit 115 168 5.2E-5 T 13-10-2018 IPR023234 NarG-like domain TOPB45_1494 b0f60de57fc6d705b87d4411d3cf9536 223 Gene3D G3DSA:1.20.950.20 71 177 9.7E-6 T 13-10-2018 TOPB45_0826 5418453ae7b3d43a4192e7828f4fc53a 151 SUPERFAMILY SSF56276 14 129 1.73E-25 T 13-10-2018 IPR016067 S-adenosylmethionine decarboxylase, core GO:0004014|GO:0008295 KEGG: 00270+4.1.1.50|KEGG: 00330+4.1.1.50|MetaCyc: PWY-6834|Reactome: R-HSA-351202 TOPB45_0826 5418453ae7b3d43a4192e7828f4fc53a 151 Gene3D G3DSA:3.60.90.10 12 143 8.1E-37 T 13-10-2018 TOPB45_0826 5418453ae7b3d43a4192e7828f4fc53a 151 TIGRFAM TIGR03330 SAM_DCase_Bsu: S-adenosylmethionine decarboxylase proenzyme 14 128 1.6E-24 T 13-10-2018 IPR017716 S-adenosylmethionine decarboxylase proenzyme GO:0004014|GO:0008295 KEGG: 00270+4.1.1.50|KEGG: 00330+4.1.1.50|MetaCyc: PWY-6834 TOPB45_0826 5418453ae7b3d43a4192e7828f4fc53a 151 Pfam PF02675 S-adenosylmethionine decarboxylase 17 128 6.5E-27 T 13-10-2018 IPR003826 S-adenosylmethionine decarboxylase family, prokaryotic GO:0004014|GO:0008295 KEGG: 00270+4.1.1.50|KEGG: 00330+4.1.1.50|MetaCyc: PWY-6834 TOPB45_0073 0c4f1de32e5e424abae3e859e97046c0 90 Pfam PF08899 Domain of unknown function (DUF1844) 13 85 4.1E-31 T 13-10-2018 IPR014995 Protein of unknown function DUF1844 TOPB45_0247 98f540ead46e4da9a8499f6306638269 274 Pfam PF01578 Cytochrome C assembly protein 70 270 6.5E-35 T 13-10-2018 IPR002541 Cytochrome c assembly protein GO:0017004|GO:0020037 TOPB45_0156 8ca40c275b656bcb18409fcadd764f80 153 Pfam PF09350 Domain of unknown function (DUF1992) 9 75 4.5E-25 T 13-10-2018 IPR018961 DnaJ homologue, subfamily C, member 28, conserved domain TOPB45_1432 358781a631c37c11984273f1b282c09a 180 Pfam PF04390 Lipopolysaccharide-assembly 38 172 7.1E-11 T 13-10-2018 IPR007485 LPS-assembly lipoprotein LptE GO:0019867|GO:0043165 TOPB45_0813 b91fff9d81570b82efab817f289f039e 240 Pfam PF04402 Protein of unknown function (DUF541) 43 235 4.7E-6 T 13-10-2018 IPR007497 Protein of unknown function DUF541 TOPB45_0862 465ba308aba5b2d05c9b7b0b0f003b89 307 Pfam PF06935 Protein of unknown function (DUF1284) 19 120 3.8E-21 T 13-10-2018 IPR009702 Protein of unknown function DUF1284 TOPB45_0979 dfb18b5573b6e75ed2745e98fd1f9a39 191 Pfam PF00293 NUDIX domain 48 160 1.2E-12 T 13-10-2018 IPR000086 NUDIX hydrolase domain GO:0016787 TOPB45_0979 dfb18b5573b6e75ed2745e98fd1f9a39 191 Gene3D G3DSA:3.90.79.10 1 191 9.7E-37 T 13-10-2018 TOPB45_0979 dfb18b5573b6e75ed2745e98fd1f9a39 191 SUPERFAMILY SSF55811 22 181 9.96E-29 T 13-10-2018 IPR015797 NUDIX hydrolase-like domain superfamily GO:0016787 TOPB45_1124 72c4b115dd125cdac78c720da9209b97 597 Pfam PF02705 K+ potassium transporter 5 532 1.9E-158 T 13-10-2018 IPR003855 Potassium transporter GO:0015079|GO:0016020|GO:0071805 TOPB45_0702 b4bad999bf663714567320dbe2e16270 66 Gene3D G3DSA:3.30.40.10 1 66 3.7E-5 T 13-10-2018 IPR013083 Zinc finger, RING/FYVE/PHD-type TOPB45_0702 b4bad999bf663714567320dbe2e16270 66 SUPERFAMILY SSF57903 4 61 2.82E-5 T 13-10-2018 IPR011011 Zinc finger, FYVE/PHD-type TOPB45_0798 32abc7474b7038b639bcb26483fc31da 331 Gene3D G3DSA:3.30.70.3460 204 331 2.4E-29 T 13-10-2018 TOPB45_0798 32abc7474b7038b639bcb26483fc31da 331 Gene3D G3DSA:3.30.70.3460 69 178 1.0E-22 T 13-10-2018 TOPB45_0746 e3f5a5c68905f933d8d1a3bd4a61ab89 156 Pfam PF08282 haloacid dehalogenase-like hydrolase 88 116 2.2E-6 T 13-10-2018 TOPB45_0746 e3f5a5c68905f933d8d1a3bd4a61ab89 156 Gene3D G3DSA:3.40.50.1000 10 150 3.0E-9 T 13-10-2018 IPR023214 HAD superfamily TOPB45_0746 e3f5a5c68905f933d8d1a3bd4a61ab89 156 SUPERFAMILY SSF56784 15 116 1.19E-12 T 13-10-2018 IPR036412 HAD-like superfamily TOPB45_0397 5ecf2ae8a287e26826a969c126678125 218 Pfam PF12225 Methylene-tetrahydrofolate reductase C terminal 111 205 1.8E-35 T 13-10-2018 IPR022026 Methylene-tetrahydrofolate reductase C-terminal TOPB45_0954 416bde9a2d5cfed4c66250a02aded745 500 SUPERFAMILY SSF56935 92 500 1.74E-14 T 13-10-2018 TOPB45_1202 1b6902c0079b5f9df6731e8fb40814f0 128 SUPERFAMILY SSF48695 83 119 2.62E-6 T 13-10-2018 IPR036280 Multiheme cytochrome superfamily TOPB45_0535 28f7c75a921863d366fd35fcfe4c4d91 252 SUPERFAMILY SSF48371 37 206 5.35E-9 T 13-10-2018 IPR016024 Armadillo-type fold TOPB45_0821 fc31e33136511484cb1f5dd4ed8b7e66 267 Pfam PF02698 DUF218 domain 87 252 2.0E-14 T 13-10-2018 IPR003848 Domain of unknown function DUF218 TOPB45_0870 189c4036e12eaadfd028d9772eed3804 285 Pfam PF01882 Protein of unknown function DUF58 182 257 7.3E-10 T 13-10-2018 IPR002881 Domain of unknown function DUF58 TOPB45_0714 77dd404d38f2abb5fc28a8f06dc3adcc 260 Pfam PF03783 Curli production assembly/transport component CsgG 40 248 9.5E-49 T 13-10-2018 IPR005534 Curli production assembly/transport component CsgG GO:0030288 TOPB45_0278 5735e03b0fe67ad3a6013c3a519e5df8 186 SUPERFAMILY SSF58104 27 175 6.54E-5 T 13-10-2018 TOPB45_1178 cad44cbb7d05b55b918ed5287469183b 117 Pfam PF10087 Uncharacterized protein conserved in bacteria (DUF2325) 3 87 1.0E-14 T 13-10-2018 IPR016772 Uncharacterised conserved protein UCP020408 TOPB45_0976 cbf2592a6e484da27cf2012926dfab33 512 Pfam PF13231 Dolichyl-phosphate-mannose-protein mannosyltransferase 61 218 5.1E-13 T 13-10-2018 IPR038731 Glycosyltransferase RgtA/B/C/D-like TOPB45_0678 1ac3d2660142390775ce98863b7f9826 242 Pfam PF03692 Putative zinc- or iron-chelating domain 21 124 2.3E-11 T 13-10-2018 IPR005358 Putative zinc- or iron-chelating domain containing protein TOPB45_0909 06f9f8d937ee5b2c0aac7e675edc600e 157 Pfam PF07012 Curlin associated repeat 82 115 8.2E-9 T 13-10-2018 IPR009742 Curlin associated GO:0007155|GO:0009289 TOPB45_0909 06f9f8d937ee5b2c0aac7e675edc600e 157 Pfam PF07012 Curlin associated repeat 104 136 2.0E-7 T 13-10-2018 IPR009742 Curlin associated GO:0007155|GO:0009289 TOPB45_1294 7029d6d6f0645ef379b461e5f117fd51 150 Pfam PF01927 Mut7-C RNAse domain 2 143 1.5E-27 T 13-10-2018 IPR002782 Mut7-C RNAse domain TOPB45_1489 0362843a4de734f2e487d46332246bab 404 Pfam PF03916 Polysulphide reductase, NrfD 58 349 3.5E-18 T 13-10-2018 IPR005614 NrfD family TOPB45_0287 3cc37cc9cef529f5803875224699f3c3 313 SUPERFAMILY SSF52833 184 254 1.6E-6 T 13-10-2018 IPR036249 Thioredoxin-like superfamily TOPB45_1243 a86d69833199770fc0af2cebb5f2cf05 374 Pfam PF01925 Sulfite exporter TauE/SafE 23 299 2.7E-35 T 13-10-2018 IPR002781 Transmembrane protein TauE-like GO:0016021 TOPB45_1169 c55dcde3305245ecd9c6672471f721cc 201 Pfam PF02666 Phosphatidylserine decarboxylase 40 194 2.7E-22 T 13-10-2018 IPR003817 Phosphatidylserine decarboxylase-related GO:0004609|GO:0008654 KEGG: 00564+4.1.1.65|MetaCyc: PWY-5669|Reactome: R-HSA-1483213 TOPB45_0579 e20b765cda5db2d161a03097afd1734a 359 Pfam PF04143 Sulphur transport 35 125 1.5E-14 T 13-10-2018 IPR007272 Sulphur transport domain TOPB45_0579 e20b765cda5db2d161a03097afd1734a 359 Pfam PF04143 Sulphur transport 197 351 4.3E-17 T 13-10-2018 IPR007272 Sulphur transport domain