locus-tag	class	description
F1847_00005	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
F1847_00015	ENOG4105BZU	Histidine kinase
F1847_00020	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
F1847_00035	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
F1847_00040	ENOG4105D7Q	type ii secretion system
F1847_00055	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
F1847_00060	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
F1847_00065	ENOG4107QMP	dna polymerase iii subunits gamma and tau
F1847_00090	ENOG4107QYG	anthranilate phosphoribosyltransferase
F1847_00095	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
F1847_00100	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
F1847_00105	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
F1847_00110	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
F1847_00120	ENOG4105DZR	Type I site-specific deoxyribonuclease
F1847_00130	ENOG4105EKX	Restriction modification system DNA (Specificity
F1847_00175	ENOG4105Y7X	Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity)
F1847_00195	ENOG4108UUM	single-stranded DNA-binding protein
F1847_00200	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
F1847_00205	ENOG4105CRE	cytochrome C
F1847_00215	ENOG4105CMI	transporter
F1847_00220	ENOG4107QWP	ABC-2 type transporter
F1847_00225	ENOG4105CJ1	ABC, transporter
F1847_00230	ENOG4105D0S	secretion protein (HlyD
F1847_00235	ENOG4105DX0	Hemolysin A
F1847_00245	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
F1847_00250	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
F1847_00255	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
F1847_00260	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
F1847_00265	ENOG4105EHZ	conserved protein UCP016719
F1847_00275	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
F1847_00280	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
F1847_00285	ENOG4105CAY	ferredoxin--nadp reductase
F1847_00295	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
F1847_00300	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
F1847_00315	ENOG41081QV	Universal stress protein
F1847_00320	ENOG4105EJ7	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity)
F1847_00340	ENOG4107QJZ	Glycosyl transferase, family 2
F1847_00370	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
F1847_00375	ENOG4108YZY	peptidylprolyl cis-trans isomerase
F1847_00380	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
F1847_00390	ENOG4105WPN	DNA integration recombination invertion protein
F1847_00400	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
F1847_00405	ENOG4107RFY	SbcCD D subunit
F1847_00410	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
F1847_00415	ENOG4105D1F	ATP-binding protein
F1847_00430	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
F1847_00435	ENOG4105C8Y	Acetylornithine aminotransferase
F1847_00450	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
F1847_00465	ENOG4107YIW	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
F1847_00470	ENOG4107QMV	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
F1847_00475	ENOG4105DIN	metallophosphoesterase
F1847_00480	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
F1847_00485	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
F1847_00495	ENOG41087NI	Sulfite exporter TauE/SafE
F1847_00550	ENOG4107UCJ	Catalyzes the synthesis of activated sulfate (By similarity)
F1847_00560	ENOG4105E12	capsule polysaccharide
F1847_00585	ENOG4105CMR	udp-glucose 4-epimerase
F1847_00605	ENOG4105DBZ	Dtdp-4-dehydrorhamnose reductase
F1847_00615	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
F1847_00625	ENOG4107V1M	polysaccharide export protein
F1847_00630	ENOG4105ECX	polysaccharide export
F1847_00640	ENOG41090SZ	ABC-2 type transporter
F1847_00650	ENOG4105XA0	heptosyltransferase ii
F1847_00655	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
F1847_00660	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
F1847_00680	ENOG4105E02	MotA TolQ exbB proton channel
F1847_00705	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
F1847_00710	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
F1847_00720	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
F1847_00725	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
F1847_00740	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
F1847_00745	ENOG4105BZA	Phosphoglycerate kinase
F1847_00750	ENOG4105BZA	Phosphoglycerate kinase
F1847_00755	ENOG4105K4P	CoA-binding domain protein
F1847_00765	ENOG4105QAX	Iron-sulfur
F1847_00775	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
F1847_00780	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
F1847_00785	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
F1847_00790	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
F1847_00795	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
F1847_00800	ENOG4105DF2	NADH dehydrogenase subunit j
F1847_00805	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
F1847_00815	ENOG4105C8S	subunit m
F1847_00820	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
F1847_00835	ENOG4105BZE	flagellar hook protein, FlgE
F1847_00840	ENOG4105BZE	flagellar hook protein, FlgE
F1847_00845	ENOG4108RAC	Rubrerythrin
F1847_00860	ENOG4105D3R	alkyl hydroperoxide reductase
F1847_00875	ENOG4105BZU	Histidine kinase
F1847_00880	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
F1847_00885	ENOG4105XFK	Ferrous iron transport protein A
F1847_00890	ENOG4105CE1	Ferrous iron transport protein b
F1847_00900	ENOG4105CGK	Exodeoxyribonuclease III
F1847_00915	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
F1847_00920	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
F1847_00930	ENOG41085CK	50S ribosomal protein L35
F1847_00935	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
F1847_00940	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
F1847_00945	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
F1847_00960	ENOG4105MAX	Superoxide reductase
F1847_00965	ENOG4105VCQ	rubredoxin
F1847_00975	ENOG4105VCQ	rubredoxin
F1847_00985	ENOG4105CNW	domain protein
F1847_00995	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
F1847_01000	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
F1847_01025	ENOG4105C34	Pseudouridine synthase
F1847_01030	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
F1847_01035	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
F1847_01050	ENOG4105VCQ	rubredoxin
F1847_01060	ENOG4105CDY	transcriptional regulatory protein
F1847_01070	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
F1847_01105	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
F1847_01130	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
F1847_01140	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
F1847_01145	ENOG4105CHR	reductase
F1847_01160	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
F1847_01165	ENOG4105HHA	aminodeoxychorismate lyase
F1847_01200	ENOG4105CAK	Cell division ATP-binding protein ftsE
F1847_01210	ENOG4105CY1	sulfite reductase, dissimilatory-type alpha subunit
F1847_01215	ENOG4105PJW	Sulfite reductase dissimilatory-type beta subunit
F1847_01220	ENOG4105Z0W	Dissimilatory sulfite reductase D
F1847_01225	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
F1847_01230	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
F1847_01235	ENOG4108HHA	Transketolase
F1847_01240	ENOG4108ZP8	Acetolactate synthase small subunit
F1847_01245	ENOG4105C7K	acetolactate synthase
F1847_01255	ENOG4107QX8	SPFH domain, Band 7 family protein
F1847_01260	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
F1847_01265	ENOG4108UJD	30S ribosomal protein S9
F1847_01270	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
F1847_01275	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
F1847_01280	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
F1847_01290	ENOG4105C8N	cysteinyl-tRNA synthetase
F1847_01295	ENOG4107R21	site-determining protein
F1847_01300	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
F1847_01305	ENOG4105CFH	Aspartokinase
F1847_01310	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
F1847_01320	ENOG4105NBF	ammecr1 domain protein
F1847_01325	ENOG4105T95	Thiol disulfide interChange protein
F1847_01330	ENOG4108TVJ	Nitroreductase
F1847_01345	ENOG4105DVC	DnaJ domain protein
F1847_01350	ENOG4108UK2	deaminase
F1847_01355	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
F1847_01360	ENOG4105CKK	Glycosyl transferase, family 2
F1847_01390	ENOG4105D1H	recombination factor protein RarA
F1847_01395	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
F1847_01400	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
F1847_01405	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
F1847_01410	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
F1847_01420	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
F1847_01425	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
F1847_01435	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
F1847_01440	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
F1847_01445	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
F1847_01450	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
F1847_01455	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
F1847_01460	ENOG41082SA	50s ribosomal protein l29
F1847_01465	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
F1847_01470	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
F1847_01475	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
F1847_01480	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
F1847_01485	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
F1847_01490	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
F1847_01495	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
F1847_01500	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
F1847_01505	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
F1847_01510	ENOG4105VPB	50S ribosomal protein L30
F1847_01515	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
F1847_01520	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
F1847_01525	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
F1847_01535	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
F1847_01545	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
F1847_01550	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
F1847_01555	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
F1847_01560	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
F1847_01565	ENOG4108ZT0	50S ribosomal protein l17
F1847_01570	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
F1847_01575	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
F1847_01580	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
F1847_01585	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
F1847_01590	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
F1847_01610	ENOG4105ECY	inositol monophosphatase
F1847_01620	ENOG4108IEC	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity)
F1847_01635	ENOG4105C7N	Xanthine uracil vitamin C permease
F1847_01645	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
F1847_01650	ENOG4105CTP	PilT protein domain protein
F1847_01655	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
F1847_01660	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
F1847_01670	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
F1847_01675	ENOG4107QJE	Chromosome Partitioning Protein
F1847_01680	ENOG4108VTU	Cdp-alcohol phosphatidyltransferase
F1847_01690	ENOG4105CQS	hydrogenase expression formation protein HypD
F1847_01695	ENOG4105DPX	Hydrogenase, large subunit
F1847_01700	ENOG4105E3S	small subunit
F1847_01710	ENOG4105BZU	Histidine kinase
F1847_01715	ENOG4105CNU	cell division protein FtsK
F1847_01725	ENOG4107T5V	SNARE associated Golgi
F1847_01735	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
F1847_01745	ENOG41072GX	Peptidase M22 Glycoprotease
F1847_01750	ENOG4105DZP	Membrane-associated zinc metalloprotease
F1847_01755	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
F1847_01770	ENOG4105W87	Cbs domain
F1847_01775	ENOG4105C2M	dna polymerase I
F1847_01780	ENOG4105FE9	pseudouridine synthase
F1847_01795	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
F1847_01815	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
F1847_01820	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
F1847_01825	ENOG41084BP	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
F1847_01830	ENOG41083MR	nifu domain-containing protein
F1847_01835	ENOG4105C01	Dihydroxy-acid dehydratase
F1847_01845	ENOG4105DHJ	ABC, transporter
F1847_01860	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
F1847_01865	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
F1847_01870	ENOG4105GYT	Protein of unknown function (DUF1009)
F1847_01875	ENOG4105CK5	oxidoreductase
F1847_01880	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
F1847_01885	ENOG4105DC1	bifunctional purine biosynthesis protein purh
F1847_01890	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
F1847_01895	ENOG4105C5R	Aminotransferase
F1847_01905	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
F1847_01915	ENOG4105CH7	arginosuccinase
F1847_01930	ENOG4105C3M	thioredoxin reductase
F1847_01935	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
F1847_01940	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
F1847_01950	ENOG4105E3H	phosphoglycerate mutase
F1847_01955	ENOG4108IYU	L-aspartate oxidase
F1847_01975	ENOG4105EGD	dinuclear metal center protein, YbgI family
F1847_01985	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
F1847_01990	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
F1847_02000	ENOG4105K70	DNA-binding protein
F1847_02010	ENOG4105F4G	Membrane
F1847_02025	ENOG4107Z7S	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
F1847_02030	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
F1847_02035	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
F1847_02040	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
F1847_02050	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
F1847_02065	ENOG41084CW	50S ribosomal protein L32
F1847_02070	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
F1847_02075	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
F1847_02100	ENOG4108V0P	LemA family
F1847_02120	ENOG4105DFM	M18 family aminopeptidase
F1847_02130	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
F1847_02140	ENOG4105F7J	membrane-bound serine protease
F1847_02145	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
F1847_02150	ENOG4105EM7	Selenocysteine-specific translation elongation factor
F1847_02155	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
F1847_02160	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
F1847_02165	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
F1847_02180	ENOG4105D64	Mechanosensitive ion channel
F1847_02190	ENOG41071I4	Phosphatidylserine decarboxylase proenzyme
F1847_02195	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
F1847_02200	ENOG4105KC4	UPF0296 protein
F1847_02205	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
F1847_02210	ENOG4105C2N	RNA methyltransferase TrmH family group 3
F1847_02230	ENOG4108ZHD	aig2 family
F1847_02235	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
F1847_02245	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
F1847_02255	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
F1847_02260	ENOG41083MZ	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
F1847_02265	ENOG4108ZC9	flagellar basal-body rod protein flgc
F1847_02270	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
F1847_02275	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
F1847_02280	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
F1847_02305	ENOG4105BZU	Histidine kinase
F1847_02310	ENOG4105BZU	Histidine kinase
F1847_02315	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
F1847_02320	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
F1847_02325	ENOG4105G5W	regulator Fur family
F1847_02335	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
F1847_02365	ENOG4105D1F	ATP-binding protein
F1847_02375	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
F1847_02395	ENOG4105D5G	Transposase
F1847_02410	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
F1847_02420	ENOG4108HRK	Histidine kinase
F1847_02425	ENOG4108NEV	two component transcriptional regulator, LytTR family
F1847_02435	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
F1847_02440	ENOG4108V6E	Cell division protein mraZ
F1847_02445	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
F1847_02460	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
F1847_02465	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
F1847_02470	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
F1847_02475	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
F1847_02480	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
F1847_02485	ENOG4105DFU	Cell wall formation (By similarity)
F1847_02500	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
F1847_02505	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
F1847_02520	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
F1847_02540	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
F1847_02545	ENOG4108R6K	riboflavin synthase, subunit alpha
F1847_02550	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
F1847_02555	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
F1847_02560	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
F1847_02575	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
F1847_02585	ENOG4105CB5	ATP-dependent DNA helicase recG
F1847_02590	ENOG4105K64	Glycosyl transferase, family 2
F1847_02595	ENOG4105BZU	Histidine kinase
F1847_02600	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
F1847_02610	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
F1847_02620	ENOG4105CKX	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP
F1847_02640	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
F1847_02650	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
F1847_02655	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
F1847_02665	ENOG4107QNG	Phosphoribosylglycinamide synthetase
F1847_02670	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
F1847_02695	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
F1847_02700	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
F1847_02710	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
F1847_02715	ENOG4105CE9	30S ribosomal protein S2
F1847_02720	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
F1847_02725	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
F1847_02730	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
F1847_02735	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
F1847_02740	ENOG4105KNE	Phosphatidate cytidylyltransferase
F1847_02750	ENOG4105CPF	Cell wall formation (By similarity)
F1847_02760	ENOG4105W4M	Transport-associated protein
F1847_02765	ENOG4105N5T	Radical SAM Protein
F1847_02775	ENOG41086K9	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
F1847_02780	ENOG4105CTB	Polyprenyl synthetase
F1847_02785	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
F1847_02790	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
F1847_02795	ENOG4105VB9	50S ribosomal protein l28
F1847_02805	ENOG4105D5G	Transposase
F1847_02810	ENOG4105D5G	Transposase
F1847_02820	ENOG4105BZU	Histidine kinase
F1847_02825	ENOG4105C9A	Phoh family
F1847_02840	ENOG4107VXZ	Hydrolase
F1847_02845	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
F1847_02850	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
F1847_02855	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
F1847_02880	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
F1847_02890	ENOG4108TVJ	Nitroreductase
F1847_02895	ENOG4105BZU	Histidine kinase
F1847_02905	ENOG4105D5G	Transposase
F1847_02955	ENOG4105D5G	Transposase
F1847_03000	ENOG4105D05	Receptor
F1847_03005	ENOG4108HUF	Transporter
F1847_03010	ENOG4108I9K	permease protein
F1847_03015	ENOG4105E0A	ABC, transporter
F1847_03025	ENOG4105EET	magnesium chelatase
F1847_03030	ENOG4105CJ1	ABC, transporter
F1847_03045	ENOG4108Z4T	Peptidase M50
F1847_03050	ENOG4105CN1	protease
F1847_03055	ENOG4105EBH	Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity)
F1847_03060	ENOG4108J2R	molybdopterin oxidoreductase
F1847_03075	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
F1847_03080	ENOG4105DVI	reductase, NrfD
F1847_03085	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
F1847_03090	ENOG4105CB1	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
F1847_03095	ENOG4105C03	ribonuclease
F1847_03100	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
F1847_03110	ENOG4105BZ1	(ABC) transporter
F1847_03115	ENOG4105D0M	Protease HtpX homolog
F1847_03125	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
F1847_03135	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
F1847_03160	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
F1847_03165	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
F1847_03170	ENOG4105VM1	flagellar
F1847_03175	ENOG4107NFR	Fructose-1,6-bisphosphatase
F1847_03185	ENOG4105SG9	biopolymer transport protein, ExbD
F1847_03195	ENOG4105CHM	Aminotransferase
F1847_03205	ENOG4105DAN	ATP-dependent protease
F1847_03210	ENOG4108HMX	isocitrate dehydrogenase (NADP)
F1847_03215	ENOG410688J	Ferredoxin
F1847_03220	ENOG4105C8T	Leucyl-tRNA synthetase
F1847_03230	ENOG4108T9Q	UPF0278 protein
F1847_03235	ENOG4105CY0	Metallo-Beta-Lactamase
F1847_03240	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
F1847_03245	ENOG4107QHF	type ii secretion system protein e
F1847_03250	ENOG41084JP	30S ribosomal protein S21
F1847_03255	ENOG4105C98	muts2 protein
F1847_03260	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
F1847_03265	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
F1847_03280	ENOG4105ERG	peptidase m48, ste24p
F1847_03310	ENOG4107S1Q	Phosphatase
F1847_03320	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
F1847_03330	ENOG4105BZU	Histidine kinase
F1847_03335	ENOG4107SVH	Potassium channel protein
F1847_03350	ENOG4107TH8	cina domain protein
F1847_03370	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
F1847_03385	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
F1847_03390	ENOG4105VB5	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
F1847_03395	ENOG4105DWF	phosphomethylpyrimidine kinase
F1847_03400	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
F1847_03410	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
F1847_03415	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
F1847_03420	ENOG41084AH	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
F1847_03425	ENOG41085QA	50S ribosomal protein l34
F1847_03430	ENOG4105DK0	Indole-3-glycerol phosphate synthase
F1847_03435	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
F1847_03440	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
F1847_03455	ENOG4105BZU	Histidine kinase
F1847_03470	ENOG4105MQ3	flagellar protein FliS
F1847_03475	ENOG410801E	Flagellar hook-associated 2 domain-containing protein
F1847_03490	ENOG4105D1F	ATP-binding protein
F1847_03500	ENOG4108JUA	Transcriptional regulator
F1847_03510	ENOG4105C5F	glutamine synthetase
F1847_03515	ENOG4105C4K	Nad synthetase
F1847_03520	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
F1847_03525	ENOG4105CEY	Amp-dependent synthetase and ligase
F1847_03535	ENOG4105CSH	Transporter
F1847_03540	ENOG4108N5B	2-phosphosulfolactate phosphatase
F1847_03550	ENOG4105FD8	phosphonate metabolism protein PhnM
F1847_03555	ENOG4105HRV	phosphonate c-p lyase system protein phnl
F1847_03560	ENOG4105ENV	phosphonate C-P lyase system protein PhnK
F1847_03585	ENOG4105S7S	phosphonate abc transporter
F1847_03590	ENOG4105D5T	phosphonate abc transporter
F1847_03635	ENOG4105D5G	Transposase
F1847_03640	ENOG4105D5G	Transposase
F1847_03655	ENOG4105BZU	Histidine kinase
F1847_03675	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
F1847_03690	ENOG4105DFU	Cell wall formation (By similarity)
F1847_03700	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
F1847_03705	ENOG4105IQJ	Involved in biosynthesis of the thiamine precursor thiazole (By similarity)
F1847_03710	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
F1847_03715	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
F1847_03720	ENOG4105CRQ	synthase (Component I)
F1847_03730	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
F1847_03735	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
F1847_03745	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
F1847_03750	ENOG4105D63	family UPF0324
F1847_03765	ENOG4105EYU	Glutamine amido-transferase
F1847_03770	ENOG4105CBC	glutamate synthase
F1847_03775	ENOG4108JU9	GAF modulated sigma54 specific transcriptional regulator Fis family
F1847_03780	ENOG4105C5F	glutamine synthetase
F1847_03785	ENOG4108JUA	Transcriptional regulator
F1847_03790	ENOG4108YZA	Nitrogen regulatory protein pii
F1847_03795	ENOG4105BZU	Histidine kinase
F1847_03810	ENOG4107QP8	phosphohexose isomerase
F1847_03815	ENOG4105D52	delta-aminolevulinic acid dehydratase
F1847_03820	ENOG4105K6T	rare lipoprotein A
F1847_03825	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
F1847_03835	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
F1847_03840	ENOG4107SDU	Methyl-accepting chemotaxis
F1847_03845	ENOG4105I3K	Ferric uptake regulator, Fur family
F1847_03850	ENOG4105D06	uba thif-type nad fad binding protein
F1847_03865	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
F1847_03900	ENOG4105DSE	periplasmic solute binding protein
F1847_03905	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
F1847_03910	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
F1847_03915	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
F1847_03920	ENOG4105ECP	epimerase
F1847_03930	ENOG4105EC8	Methyl-accepting chemotaxis
F1847_03940	ENOG4105C8Q	Methyl-accepting chemotaxis
F1847_03945	ENOG4107ZTM	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
F1847_03955	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
F1847_03960	ENOG4105CTQ	phosphohexokinase
F1847_03965	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
F1847_03970	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
F1847_03980	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
F1847_03990	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
F1847_04005	ENOG4105CG5	Glycosyl transferase (Group 1
F1847_04010	ENOG4105CAQ	asparagine synthetase
F1847_04025	ENOG4105CG5	Glycosyl transferase (Group 1
F1847_04045	ENOG4107RA4	Glycosyl transferase (Group 1
F1847_04050	ENOG4105ESV	Glycosyl transferase, family 4
F1847_04070	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
F1847_04080	ENOG4105CAT	Cytidine monophosphate kinase
F1847_04085	ENOG4105M7K	Involved in the transcription termination process (By similarity)
F1847_04090	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
F1847_04095	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
F1847_04100	ENOG4105KEG	ribosomal-protein-alanine acetyltransferase
F1847_04105	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
F1847_04110	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
F1847_04115	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
F1847_04125	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
F1847_04130	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
F1847_04145	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
F1847_04155	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
F1847_04160	ENOG4107G9V	glycosyl transferase, family 39
F1847_04170	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
F1847_04175	ENOG4105CDH	Citrulline--aspartate ligase
F1847_04185	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
F1847_04190	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
F1847_04195	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
F1847_04205	ENOG4105W5Q	DNA repair protein (RadC
F1847_04210	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
F1847_04215	ENOG4108Z6B	deaminase
F1847_04220	ENOG4105BZU	Histidine kinase
F1847_04235	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
F1847_04245	ENOG4105C22	threonyL-tRNA synthetase
F1847_04250	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
F1847_04265	ENOG4107YUK	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
F1847_04270	ENOG4105FF6	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
F1847_04275	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
F1847_04280	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
F1847_04305	ENOG41088YS	Glycosyl transferase (Group 1
F1847_04325	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
F1847_04330	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
F1847_04335	ENOG4105MRR	Transcriptional regulator (By similarity)
F1847_04365	ENOG4105C37	(CBS) domain
F1847_04370	ENOG4105C37	(CBS) domain
F1847_04385	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
F1847_04390	ENOG4107VRB	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
F1847_04450	ENOG4105CAS	nag kinase
F1847_04455	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
F1847_04465	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
F1847_04470	ENOG4108JA2	transcriptioN-repair coupling factor
F1847_04480	ENOG4105C4R	Atp-dependent dna helicase
F1847_04485	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
F1847_04490	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
F1847_04495	ENOG4108EE5	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
F1847_04500	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
F1847_04510	ENOG4105CUB	amino acid
F1847_04515	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
F1847_04525	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
F1847_04535	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
F1847_04545	ENOG4107EEM	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
F1847_04550	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
F1847_04555	ENOG41074MP	UPF0103 Mediator of ErbB2-driven cell motility-containing protein
F1847_04560	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
F1847_04570	ENOG41082E4	Binds directly to 16S ribosomal RNA (By similarity)
F1847_04585	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
F1847_04600	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
F1847_04605	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
F1847_04610	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
F1847_04620	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
F1847_04625	ENOG4105CHV	Transcription elongation factor NusA
F1847_04635	ENOG4105CQC	Prephenate dehydratase
F1847_04640	ENOG4105D0M	Protease HtpX homolog
F1847_04650	ENOG4108194	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
F1847_04655	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
F1847_04660	ENOG4105CBS	Chea signal transduction histidine kinase
F1847_04665	ENOG4108V3W	Chemotaxis protein, CheW
F1847_04675	ENOG4108N3W	hemolysin secretion protein
F1847_04680	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
F1847_04685	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
F1847_04690	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
F1847_04695	ENOG4105EE5	Membrane protein terC
F1847_04700	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
F1847_04755	ENOG4105CIH	Imidazole acetol-phosphate transaminase
F1847_04760	ENOG4105DIW	FeS assembly protein SUFB
F1847_04770	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
F1847_04775	ENOG4105C4M	(Ubiquinol oxidase) subunit I
F1847_04785	ENOG4105BZU	Histidine kinase
F1847_04805	ENOG4105C8V	SAICAR synthetase
F1847_04840	ENOG4108VKV	Monofunctional biosynthetic peptidoglycan transglycosylase
F1847_04845	ENOG4105E3H	phosphoglycerate mutase
F1847_04855	ENOG4107XQ1	cobalamin (vitamin B12) biosynthesis CbiM protein
F1847_04860	ENOG4108A51	
F1847_04890	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
F1847_04915	ENOG4105BZU	Histidine kinase
F1847_04920	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
F1847_04925	ENOG4108VYJ	response regulator receiver protein
F1847_04945	ENOG4108VYJ	response regulator receiver protein
F1847_04950	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
F1847_04955	ENOG4107R21	site-determining protein
F1847_04960	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
F1847_04965	ENOG4105D7B	Flagellar biosynthesis protein flha
F1847_04970	ENOG4105D00	flagellar biosynthetic protein flhB
F1847_04975	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
F1847_04980	ENOG4105VS8	Flagellar biosynthetic protein fliq
F1847_04985	ENOG4105CN7	Flagellar biosynthetic protein FliP
F1847_04995	ENOG4105DD5	Flagellar motor switch protein
F1847_05000	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
F1847_05025	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
F1847_05030	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
F1847_05035	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
F1847_05040	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
F1847_05055	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
F1847_05060	ENOG4108RWN	rrna methyltransferase
F1847_05085	ENOG4105DR4	Methyltransferase
F1847_05090	ENOG4105HEE	Binding Domain protein
F1847_05095	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
F1847_05105	ENOG4105C8B	TIGR00159 family
F1847_05115	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
F1847_05125	ENOG4108IUZ	ABC transporter
F1847_05150	ENOG4108UVJ	appr-1-p processing domain protein
F1847_05160	ENOG4105C8Q	Methyl-accepting chemotaxis
F1847_05165	ENOG4105CWE	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
F1847_05170	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
F1847_05175	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
F1847_05180	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
F1847_05185	ENOG41066VF	YeeE YedE family protein
F1847_05190	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
F1847_05195	ENOG4105DCG	PHP domain protein
F1847_05200	ENOG4105DZ1	carboxypeptidase
F1847_05205	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
F1847_05210	ENOG4105C5X	domain protein
F1847_05215	ENOG4107ZC0	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
F1847_05225	ENOG4105E2X	shikimate dehydrogenase
F1847_05230	ENOG41084GS	Type I DHQase
F1847_05235	ENOG4105DC1	bifunctional purine biosynthesis protein purh
F1847_05240	ENOG4105EZY	Pyrroloquinoline quinone biosynthesis protein E
F1847_05250	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
F1847_05255	ENOG4105C25	Primosomal protein n'
F1847_05260	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
F1847_05270	ENOG4105CZX	twitching motility protein
F1847_05275	ENOG4105CZX	twitching motility protein
F1847_05290	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
F1847_05300	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
F1847_05310	ENOG4105DJ0	Poly(A) Polymerase
F1847_05315	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
F1847_05325	ENOG4105D5G	Transposase
F1847_05335	ENOG4108PCN	EamA-like transporter family
F1847_05340	ENOG4105FE9	pseudouridine synthase
F1847_05350	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
F1847_05360	ENOG4107R56	PP-loop domain protein
F1847_05365	ENOG41082X2	rubredoxin
F1847_05370	ENOG4107S90	membrAne
F1847_05375	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
F1847_05380	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
F1847_05385	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
F1847_05395	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
F1847_05400	ENOG4105CQB	FAD linked oxidase domain protein
F1847_05405	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
F1847_05410	ENOG4108JQ7	(ABC) transporter
F1847_05425	ENOG4105DBV	ornithine carbamoyltransferase
F1847_05445	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
F1847_05450	ENOG4105DDK	oxidoreductase, beta subunit
F1847_05460	ENOG4105E8R	UPF0173 metal-dependent hydrolase
F1847_05490	ENOG4107R7I	amino acid
F1847_05505	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
F1847_05515	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
F1847_05535	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
F1847_05540	ENOG4105C31	Tryptophanyl-tRNA synthetase
F1847_05555	ENOG4108NWD	Cytochrome
F1847_05570	ENOG4105DZS	Phenylacetate-CoA ligase
F1847_05580	ENOG4105C1J	atp-dependent rna helicase
F1847_05585	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
F1847_05590	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
F1847_05600	ENOG4105DCU	2-hydroxyglutaryl-CoA dehydratase
F1847_05605	ENOG4105CIZ	coA-substrate-specific enzyme activase
F1847_05610	ENOG4105DUM	transcriptional regulator, lysR family
F1847_05630	ENOG4105VFE	sira family
F1847_05650	ENOG41061AI	Protein of unknown function (DUF2905)
F1847_05655	ENOG4105DVY	radical SAM domain protein
F1847_05670	ENOG4105CM2	brancheD-chain amino acid aminotransferase
F1847_05680	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
F1847_05685	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
F1847_05695	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
F1847_05700	ENOG4107Z3H	Transcriptional regulator, TetR family
F1847_05715	ENOG4105CHM	Aminotransferase
F1847_05730	ENOG4107QXI	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity)
F1847_05735	ENOG4105E4G	Type IV pilus
F1847_05765	ENOG410890F	Dynamin family
F1847_05785	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
F1847_05795	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
F1847_05805	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
F1847_05835	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
F1847_05850	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
F1847_05855	ENOG4105K46	50S ribosomal protein l27
F1847_05860	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
F1847_05870	ENOG4105WCJ	ec 1.1.1.193
F1847_05875	ENOG4105C5I	Dehydrogenase
F1847_05880	ENOG4107QW4	alcohol dehydrogenase
F1847_05885	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
F1847_05895	ENOG4107SYB	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
F1847_05905	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
F1847_05910	ENOG4105D48	metallophosphoesterase
F1847_05915	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
F1847_05960	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
F1847_05975	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
F1847_05985	ENOG4105VFF	UPF0102 protein
F1847_05990	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
F1847_05995	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
F1847_06030	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
F1847_06035	ENOG410816I	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
F1847_06040	ENOG4105C6E	dna polymerase iii
F1847_06045	ENOG4105D5U	fad dependent oxidoreductase
F1847_06050	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
F1847_06055	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
F1847_06060	ENOG4105DXN	mazG family
F1847_06065	ENOG4105FDK	ABC transporter
F1847_06070	ENOG4105FAV	ABC, transporter
F1847_06075	ENOG4105F8V	Hydrolase, tatD family
F1847_06080	ENOG4105C9M	aspartyl-trna synthetase
F1847_06090	ENOG4105C10	Electron transfer flavoprotein
F1847_06095	ENOG4105BZJ	Electron transfer flavoprotein
F1847_06100	ENOG4105C1G	acyl-Coa dehydrogenase
F1847_06105	ENOG4105KQC	Competence protein
F1847_06110	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
F1847_06125	ENOG4105C75	arginyL-tRNA synthetase
F1847_06135	ENOG4105EI2	Pseudouridine synthase
F1847_06145	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
F1847_06150	ENOG4105CFG	Acts as a chaperone (By similarity)
F1847_06155	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
F1847_06160	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
F1847_06165	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
F1847_06175	ENOG4107RD7	Flagellar Motor Protein, MotA
F1847_06190	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
F1847_06205	ENOG4105DFA	alanine racemase domain protein
F1847_06210	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
F1847_06215	ENOG41082MC	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
F1847_06220	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
F1847_06225	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
F1847_06230	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
F1847_06235	ENOG4105E3N	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
F1847_06245	ENOG4108Q71	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
F1847_06250	ENOG4105CNI	cell division protein FtsW
F1847_06255	ENOG4105CJN	penicillin-binding protein
F1847_06265	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
F1847_06270	ENOG4105D98	threonine synthase
F1847_06285	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
F1847_06300	ENOG4105CHM	Aminotransferase
F1847_06305	ENOG4107SDT	Homocitrate synthase
F1847_06320	ENOG4105E1Q	flagellar hook-associated protein
F1847_06335	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
F1847_06340	ENOG4107W7W	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
F1847_06350	ENOG4105CGA	flagellar basal-body rod protein FlgG
F1847_06355	ENOG4108JQA	flagellar
F1847_06360	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F1847_06370	ENOG4105D60	lipoprotein releasing system transmembrane protein
F1847_06375	ENOG4105CRK	lysyL-tRNA synthetase
F1847_06380	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
F1847_06385	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
F1847_06390	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
F1847_06405	ENOG4105DIT	ErfK YbiS YcfS YnhG family protein
F1847_06420	ENOG4105K5M	30s ribosomal protein S16
F1847_06425	ENOG4105VB6	UPF0109 protein
F1847_06430	ENOG410836E	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
F1847_06435	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
F1847_06440	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
F1847_06445	ENOG4106063	Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit
F1847_06450	ENOG4107YU2	histidine triad (hIT) protein
F1847_06455	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
F1847_06460	ENOG4105MA4	psp1 domain protein
F1847_06465	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
F1847_06475	ENOG4105W49	UPF0434 protein
F1847_06480	ENOG4105BZU	Histidine kinase
F1847_06495	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
F1847_06500	ENOG4108JVH	Protein of unknown function DUF43
F1847_06510	ENOG4108UMR	transcriptional regulator AsnC family
F1847_06520	ENOG4105ES5	Histidine kinase
F1847_06535	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
F1847_06540	ENOG41082V8	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
F1847_06545	ENOG4108YZG	isomerase
F1847_06550	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
F1847_06555	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
F1847_06570	ENOG4107R7Y	intracellular protease Pfpi family
F1847_06585	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
F1847_06600	ENOG4105VEQ	Cold shock protein
F1847_06610	ENOG4108MYP	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
F1847_06615	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
F1847_06620	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
F1847_06630	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
F1847_06640	ENOG4105DC7	peptidase M24
F1847_06645	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
F1847_06650	ENOG4105DB7	PHP domain protein
F1847_06655	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
F1847_06680	ENOG4105CJR	Integral membrane protein (MviN
F1847_06685	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
F1847_06690	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
F1847_06705	ENOG4105M15	transport protein ExbD
F1847_06710	ENOG4105M8K	biopolymer transport protein
F1847_06715	ENOG4105CSA	Coproporphyrinogen iii oxidase
F1847_06720	ENOG4107S47	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity)
F1847_06740	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
F1847_06755	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
F1847_06760	ENOG4105CIZ	coA-substrate-specific enzyme activase
F1847_06775	ENOG4107WJT	it plays a direct role in the translocation of protons across the membrane (By similarity)
F1847_06780	ENOG4105VH4	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
F1847_06785	ENOG4105C0P	Mg chelatase subunit ChlI
F1847_06790	ENOG4105CR7	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity)
F1847_06795	ENOG4105VFE	sira family
F1847_06815	ENOG4107QXV	Phosphate transporter
F1847_06880	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
F1847_06890	ENOG4107S1E	Beta-lactamase
F1847_06900	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
F1847_06905	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
F1847_06930	ENOG4105C2X	Arabinose 5-phosphate isomerase
F1847_06935	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
F1847_06940	ENOG4105C98	muts2 protein
F1847_06955	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
F1847_06960	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
F1847_06965	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
F1847_06970	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
F1847_06980	ENOG4105F7V	ErfK ybiS ycfS ynhG family protein
F1847_06990	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
F1847_06995	ENOG4105MJ2	Competence protein
F1847_07000	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
F1847_07005	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
F1847_07085	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
F1847_07090	ENOG4107QR0	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
F1847_07095	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
F1847_07100	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
F1847_07105	ENOG4108VZM	50s ribosomal protein L10
F1847_07115	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
F1847_07135	ENOG4105WDJ	50S ribosomal protein L33
F1847_07140	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
F1847_07170	ENOG4105EWK	phytoene
F1847_07190	ENOG4107RIQ	Sulfate adenylate transferase
F1847_07195	ENOG4105EAH	synthase
F1847_07205	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
F1847_07210	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
F1847_07225	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
F1847_07235	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
F1847_07245	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
F1847_07255	ENOG4105D5G	Transposase
F1847_07260	ENOG4105D5G	Transposase
F1847_07270	ENOG4105ZHF	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
F1847_07275	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
F1847_07325	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
F1847_07330	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
F1847_07335	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
F1847_07345	ENOG4105BZU	Histidine kinase
F1847_07350	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
F1847_07355	ENOG4107QMV	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
F1847_07360	ENOG4105C8U	phosphate abc transporter
F1847_07365	ENOG4105E2Z	phosphate ABC transporter (Permease
F1847_07370	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
F1847_07375	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
F1847_07380	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
F1847_07425	ENOG4105C83	adenylosuccinate lyase
F1847_07440	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
F1847_07445	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
F1847_07450	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
F1847_07455	ENOG4105CDU	Replicative dna helicase
F1847_07475	ENOG4105DFH	Transport of potassium into the cell (By similarity)
F1847_07480	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
F1847_07490	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
F1847_07500	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
F1847_07505	ENOG4107SS6	2-dehydro-3-deoxygluconokinase
F1847_07515	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
F1847_07520	ENOG41062QD	Membrane
F1847_07525	ENOG4107QN1	sodium solute
F1847_07535	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
F1847_07555	ENOG4107QW8	radical SAM domain protein
F1847_07560	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
F1847_07575	ENOG4108IJ0	Aspartate ammonia-lyase
F1847_07585	ENOG4107QHI	-hydrogenase
F1847_07590	ENOG4107QHI	-hydrogenase
F1847_07595	ENOG4107QIZ	NADH dehydrogenase
F1847_07600	ENOG4107S2Z	UPF0761 membrane protein
F1847_07615	ENOG4107QHF	type ii secretion system protein e
F1847_07645	ENOG4105GVR	general secretion pathway protein D
F1847_07660	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
F1847_07665	ENOG4107YZX	Universal stress protein
F1847_07690	ENOG4105FDP	GntR family transcriptional regulator
F1847_07700	ENOG4105D5G	Transposase
F1847_07705	ENOG4105D5G	Transposase
F1847_07710	ENOG4105CA9	Pyruvate kinase
F1847_07715	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
F1847_07730	ENOG4105BZU	Histidine kinase
F1847_07735	ENOG4108USZ	hydrogenase
F1847_07745	ENOG4105WMM	Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity)
F1847_07750	ENOG4105C45	hydrogenase expression formation protein (HypE)
F1847_07760	ENOG4105C3M	thioredoxin reductase
F1847_07770	ENOG4105BZU	Histidine kinase
F1847_07775	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
F1847_07780	ENOG4105C8Q	Methyl-accepting chemotaxis
F1847_07785	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
F1847_07790	ENOG4105C8S	subunit m
F1847_07795	ENOG4108JPZ	Monovalent cation H antiporter subunit D
F1847_07805	ENOG4108JPZ	Monovalent cation H antiporter subunit D
F1847_07810	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
F1847_07820	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
F1847_07825	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
F1847_07830	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
F1847_07835	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
F1847_07840	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
F1847_07845	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
F1847_07850	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
F1847_07855	ENOG4108J2R	molybdopterin oxidoreductase
F1847_07860	ENOG4105CJ5	hydrogenase 2 b cytochrome subunit
F1847_07865	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
F1847_07870	ENOG4105F1C	cytochrome c
F1847_07875	ENOG4107QQM	Cysteine-rich domain
F1847_07890	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
F1847_07895	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
F1847_07910	ENOG4107WHI	formate dehydrogenase, beta subunit
F1847_07930	ENOG4105HD0	Transcriptional regulator of molybdate metabolism, LysR family
F1847_07935	ENOG4105DZS	Phenylacetate-CoA ligase
F1847_07945	ENOG4105DZS	Phenylacetate-CoA ligase
F1847_07960	ENOG4105D5G	Transposase
F1847_07970	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
F1847_08000	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
F1847_08010	ENOG4105BZU	Histidine kinase
F1847_08015	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
F1847_08020	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
F1847_08035	ENOG4107SBE	Glycosyl transferase (Group 1
F1847_08055	ENOG4107TAE	Glycosyl transferase (Group 1
F1847_08060	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
F1847_08070	ENOG4105BZU	Histidine kinase
F1847_08080	ENOG4105DFF	Rod shape-determining protein mreb
F1847_08095	ENOG4105CHM	Aminotransferase
F1847_08100	ENOG4105CZA	synthase
F1847_08105	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
F1847_08115	ENOG4105DDQ	anthranilate synthase
F1847_08120	ENOG4105CRQ	synthase (Component I)
F1847_08125	ENOG4105CUT	histidyl-tRNA synthetase
F1847_08130	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
F1847_08135	ENOG4105CE1	Ferrous iron transport protein b
F1847_08140	ENOG4105DC7	peptidase M24
F1847_08165	ENOG410695F	Crispr-associated protein, Csm1 family
F1847_08175	ENOG4108W8W	CRISPR-associated RAMP protein, Csm3 family
F1847_08220	ENOG41084EC	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
F1847_08225	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
F1847_08255	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
F1847_08260	ENOG41076CZ	activating enzyme
F1847_08275	ENOG4105PGM	cation diffusion facilitator family transporter
F1847_08285	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
F1847_08300	ENOG4107YZX	Universal stress protein
F1847_08315	ENOG4107QR9	Iron-sulfur cluster binding protein
F1847_08320	ENOG4108ZZK	Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity)
F1847_08325	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
F1847_08330	ENOG4105CQB	FAD linked oxidase domain protein
F1847_08335	ENOG4105DAA	L-lactate
F1847_08340	ENOG4105CD5	CoA-binding domain protein
F1847_08360	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
F1847_08365	ENOG4105DDK	oxidoreductase, beta subunit
F1847_08370	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
F1847_08375	ENOG4108HM5	NADH-ubiquinone oxidoreductase chain 49kDa
F1847_08385	ENOG4105D65	subunit l
F1847_08390	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
F1847_08395	ENOG4105C47	NADH ubiquinone oxidoreductase 20 kda subunit
F1847_08405	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
F1847_08425	ENOG4105D5G	Transposase
F1847_08435	ENOG4107SDU	Methyl-accepting chemotaxis
F1847_08440	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
F1847_08450	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
F1847_08455	ENOG4105DKF	Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity)
F1847_08460	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
F1847_08475	ENOG4105C6T	cysteine synthase
F1847_08485	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
F1847_08490	ENOG4105CD3	dihydroorotase
F1847_08515	ENOG4105C0H	protease
F1847_08525	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
F1847_08530	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
F1847_08540	ENOG4105E4C	Lytic transglycosylase catalytic
F1847_08560	ENOG4105DZA	Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity)
F1847_08565	ENOG4107VP5	methyltetrahydrofolate corrinoid iron-sulfur protein methyltransferase
F1847_08570	ENOG4105EYX	Acetyl-CoA decarbonylase synthase complex subunit gamma
F1847_08575	ENOG4105E8X	CO dehydrogenase acetyl-CoA synthase complex beta subunit
F1847_08580	ENOG4106HYN	CO dehydrogenase acetyl-CoA synthase delta subunit
F1847_08600	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
F1847_08605	ENOG4105CKU	formyltetrahydrofolate synthetase
F1847_08610	ENOG4105C1V	Peptidase, M16
F1847_08615	ENOG4108097	ATP-binding protein
F1847_08630	ENOG4105KCK	Peptidoglycan-associated lipoprotein
F1847_08645	ENOG4105C59	p-type ATPase
F1847_08665	ENOG4105D5G	Transposase
F1847_08675	ENOG4105C0D	helicase
F1847_08705	ENOG4105D5G	Transposase
F1847_08745	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
F1847_08750	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
F1847_08755	ENOG4105D49	3-dehydroquinate synthase
F1847_08760	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
F1847_08765	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
F1847_08785	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
F1847_08805	ENOG4105D5G	Transposase
F1847_08810	ENOG4105D5G	Transposase
F1847_08835	ENOG4108WS4	fmn reductase
F1847_08845	ENOG4108UXE	Protein tyrosine phosphatase
F1847_08860	ENOG4108M8H	domain protein
F1847_08865	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
F1847_08870	ENOG4105C0B	DNA polymerase III (alpha subunit)
F1847_08875	ENOG41090A1	ferritin
F1847_08880	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
F1847_08885	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
F1847_08900	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
F1847_08910	ENOG4105DJV	ribulose-phosphate 3-epimerase
F1847_08915	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
F1847_08920	ENOG4105EJZ	Glucose-1-phosphate cytidylyltransferase
F1847_08935	ENOG4105C7K	acetolactate synthase
F1847_08945	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
F1847_08955	ENOG4108DMA	Nad-dependent epimerase dehydratase
F1847_08965	ENOG4105EJZ	Glucose-1-phosphate cytidylyltransferase
F1847_08995	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
F1847_09000	ENOG41082DI	50s ribosomal protein l31
F1847_09010	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
F1847_09015	ENOG4107QUV	Domain protein
F1847_09020	ENOG4108UKJ	Cdp-alcohol phosphatidyltransferase
F1847_09025	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
F1847_09060	ENOG4108JQC	penicillin-binding protein 1A
F1847_09065	ENOG41080XQ	Signal transduction protein with cbs domains
F1847_09070	ENOG4105CRE	cytochrome C
F1847_09075	ENOG4106K5Q	Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity)
F1847_09080	ENOG4107QI6	Cysteine desulfurase
F1847_09085	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
F1847_09090	ENOG4106DSS	Tartrate dehydratase subunit alpha
F1847_09100	ENOG4106H78	methyltransferase
F1847_09105	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
F1847_09110	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
F1847_09120	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
F1847_09155	ENOG4105C3G	gtp-binding protein
F1847_09160	ENOG4107YD3	Thioesterase
F1847_09165	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)