locus-tag	class	description
TDSAC_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TDSAC_0002	COG0592	DNA-directed DNA polymerase activity
TDSAC_0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TDSAC_0005	COG0187	DNA topoisomerase II activity
TDSAC_0006	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TDSAC_0007	COG0142	geranyltranstransferase activity
TDSAC_0009	COG1191	sigma factor activity
TDSAC_0012	COG1360	Flagellar Motor Protein
TDSAC_0014	COG2201	protein-glutamate methylesterase activity
TDSAC_0016	COG1338	Plays a role in the flagellum-specific transport system
TDSAC_0017	COG2201	protein-glutamate methylesterase activity
TDSAC_0018	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TDSAC_0019	COG1776	CheC inhibitor of MCP methylation
TDSAC_0020	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
TDSAC_0021	COG1987	bacterial-type flagellum assembly
TDSAC_0022	COG1684	flagellar biosynthetic protein fliR
TDSAC_0023	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TDSAC_0027	COG2198	Histidine kinase
TDSAC_0027	COG0643	Histidine kinase
TDSAC_0029	COG1815	bacterial-type flagellum-dependent cell motility
TDSAC_0030	COG0741	lytic transglycosylase activity
TDSAC_0031	COG5001	Diguanylate cyclase
TDSAC_0031	COG3300	MHYT domain
TDSAC_0035	COG1151	hydroxylamine reductase activity
TDSAC_0043	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TDSAC_0044	COG0459	protein refolding
TDSAC_0045	COG3290	protein histidine kinase activity
TDSAC_0045	COG0840	transmembrane signaling receptor activity
TDSAC_0049	COG0405	Gamma-glutamyltransferase
TDSAC_0050	COG0277	FAD linked oxidase domain protein
TDSAC_0051	COG0450	alkyl hydroperoxide reductase
TDSAC_0055	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TDSAC_0057	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TDSAC_0059	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
TDSAC_0060	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TDSAC_0062	COG2877	3-deoxy-8-phosphooctulonate synthase activity
TDSAC_0063	COG0517	IMP dehydrogenase activity
TDSAC_0063	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TDSAC_0064	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
TDSAC_0066	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TDSAC_0068	COG1285	pathogenesis
TDSAC_0071	COG1067	ATP-dependent peptidase activity
TDSAC_0078	COG0419	ATPase involved in DNA repair
TDSAC_0079	COG0420	3'-5' exonuclease activity
TDSAC_0082	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
TDSAC_0083	COG1140	nitrate reductase beta subunit
TDSAC_0085	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
TDSAC_0086	COG2181	nitrate reductase activity
TDSAC_0087	COG0426	domain, Protein
TDSAC_0091	COG2226	methyltransferase
TDSAC_0093	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TDSAC_0094	COG0644	oxidoreductase
TDSAC_0096	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TDSAC_0103	COG0070	glutamate synthase
TDSAC_0103	COG0067	glutamate synthase
TDSAC_0103	COG0069	glutamate synthase activity
TDSAC_0104	COG0493	'glutamate synthase
TDSAC_0105	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TDSAC_0106	COG0511	ligase activity, forming carbon-carbon bonds
TDSAC_0107	COG0439	Biotin carboxylase
TDSAC_0108	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TDSAC_0109	COG0107	imidazoleglycerol-phosphate synthase activity
TDSAC_0110	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TDSAC_0111	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TDSAC_0112	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TDSAC_0113	COG1160	GTP binding
TDSAC_0114	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TDSAC_0119	COG0859	PFAM glycosyl transferase family 9
TDSAC_0120	COG0497	DNA recombination
TDSAC_0124	COG0411	ABC transporter
TDSAC_0126	COG2033	superoxide reductase activity
TDSAC_0128	COG5298	Protein conserved in bacteria
TDSAC_0132	COG0497	DNA recombination
TDSAC_0135	COG0347	Belongs to the P(II) protein family
TDSAC_0136	COG0019	diaminopimelate decarboxylase activity
TDSAC_0137	COG0726	polysaccharide deacetylase
TDSAC_0138	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TDSAC_0140	COG1418	mRNA catabolic process
TDSAC_0141	COG1692	metallophosphoesterase
TDSAC_0142	COG0343	queuine tRNA-ribosyltransferase activity
TDSAC_0143	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TDSAC_0144	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TDSAC_0149	COG1674	ftsk spoiiie
TDSAC_0153	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
TDSAC_0154	COG0463	Glycosyl transferase, family 2
TDSAC_0154	COG1216	Glycosyl transferase, family 2
TDSAC_0162	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TDSAC_0164	COG1157	protein secretion by the type III secretion system
TDSAC_0165	COG1419	protein localization to endoplasmic reticulum
TDSAC_0166	COG0455	bacterial-type flagellum organization
TDSAC_0168	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TDSAC_0171	COG1215	transferase activity, transferring glycosyl groups
TDSAC_0174	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TDSAC_0175	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TDSAC_0177	COG0281	malic enzyme
TDSAC_0181	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TDSAC_0182	COG0493	'glutamate synthase
TDSAC_0185	COG0481	GTPase activity
TDSAC_0186	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TDSAC_0189	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TDSAC_0189	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TDSAC_0190	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TDSAC_0191	COG0322	excinuclease ABC activity
TDSAC_0193	COG0739	heme binding
TDSAC_0195	COG0739	heme binding
TDSAC_0196	COG0612	Peptidase, M16
TDSAC_0197	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TDSAC_0198	COG2359	stage V sporulation protein S
TDSAC_0199	COG1187	pseudouridine synthase activity
TDSAC_0200	COG0425	Belongs to the sulfur carrier protein TusA family
TDSAC_0201	COG1104	cysteine desulfurase activity
TDSAC_0203	COG0728	peptidoglycan biosynthetic process
TDSAC_0205	COG2359	stage V sporulation protein S
TDSAC_0207	COG0739	heme binding
TDSAC_0209	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TDSAC_0210	COG0393	Putative heavy-metal-binding
TDSAC_0211	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TDSAC_0211	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TDSAC_0212	COG0084	hydrolase, TatD family'
TDSAC_0213	COG1355	regulation of microtubule-based process
TDSAC_0214	COG1324	tolerance protein
TDSAC_0215	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TDSAC_0218	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TDSAC_0224	COG1105	Belongs to the carbohydrate kinase PfkB family
TDSAC_0227	COG0805	protein transport
TDSAC_0228	COG0746	molybdenum cofactor guanylyltransferase activity
TDSAC_0229	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TDSAC_0230	COG2252	PERMEase
TDSAC_0232	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TDSAC_0234	COG2199	diguanylate cyclase activity
TDSAC_0234	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TDSAC_0235	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TDSAC_0236	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TDSAC_0237	COG0583	DNA-binding transcription factor activity
TDSAC_0238	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TDSAC_0239	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TDSAC_0240	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TDSAC_0242	COG0438	transferase activity, transferring glycosyl groups
TDSAC_0244	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TDSAC_0246	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TDSAC_0248	COG1309	transcriptional regulator
TDSAC_0250	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
TDSAC_0251	COG0438	transferase activity, transferring glycosyl groups
TDSAC_0252	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TDSAC_0253	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TDSAC_0254	COG1793	dna ligase
TDSAC_0256	COG2199	diguanylate cyclase activity
TDSAC_0256	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TDSAC_0258	COG0012	GTP binding
TDSAC_0261	COG0360	Binds together with S18 to 16S ribosomal RNA
TDSAC_0262	COG0629	single-stranded DNA binding
TDSAC_0263	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TDSAC_0266	COG0358	DNA primase activity
TDSAC_0268	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TDSAC_0270	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TDSAC_0271	COG0193	aminoacyl-tRNA hydrolase activity
TDSAC_0273	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
TDSAC_0273	COG0165	Argininosuccinate lyase
TDSAC_0274	COG0736	holo-[acyl-carrier-protein] synthase activity
TDSAC_0276	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TDSAC_0277	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TDSAC_0279	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TDSAC_0281	COG1966	Carbon starvation protein
TDSAC_0282	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TDSAC_0283	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TDSAC_0285	COG0719	Fe-S assembly protein
TDSAC_0286	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TDSAC_0289	COG0543	2 iron, 2 sulfur cluster binding
TDSAC_0291	COG0590	tRNA wobble adenosine to inosine editing
TDSAC_0294	COG1388	LysM domain
TDSAC_0294	COG0791	NLP P60 protein
TDSAC_0295	COG0655	NAD(P)H dehydrogenase (quinone) activity
TDSAC_0296	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
TDSAC_0296	COG0662	Cupin 2, conserved barrel domain protein
TDSAC_0298	COG0402	S-adenosylhomocysteine deaminase activity
TDSAC_0299	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TDSAC_0303	COG0432	Pfam Uncharacterised protein family UPF0047
TDSAC_0305	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TDSAC_0306	COG0628	permease
TDSAC_0307	COG1012	belongs to the aldehyde dehydrogenase family
TDSAC_0308	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TDSAC_0308	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TDSAC_0310	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
TDSAC_0311	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TDSAC_0321	COG0248	Ppx GppA phosphatase
TDSAC_0322	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TDSAC_0328	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
TDSAC_0329	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TDSAC_0330	COG0542	response to heat
TDSAC_0332	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
TDSAC_0334	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
TDSAC_0343	COG1929	Belongs to the glycerate kinase type-1 family
TDSAC_0344	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TDSAC_0347	COG0475	glutathione-regulated potassium exporter activity
TDSAC_0349	COG0009	L-threonylcarbamoyladenylate synthase
TDSAC_0350	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TDSAC_0353	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TDSAC_0364	COG0662	Cupin 2, conserved barrel domain protein
TDSAC_0365	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TDSAC_0375	COG1388	LysM domain
TDSAC_0375	COG3858	chitin binding
TDSAC_0386	COG1215	transferase activity, transferring glycosyl groups
TDSAC_0389	COG1216	Glycosyl transferase, family 2
TDSAC_0389	COG0438	transferase activity, transferring glycosyl groups
TDSAC_0400	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TDSAC_0401	COG1850	ribulose-bisphosphate carboxylase activity
TDSAC_0402	COG0572	uridine kinase
TDSAC_0403	COG3959	Transketolase, thiamine diphosphate binding domain
TDSAC_0404	COG3958	Transketolase
TDSAC_0405	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TDSAC_0406	COG0126	phosphoglycerate kinase activity
TDSAC_0407	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
TDSAC_0408	COG0698	ribose 5-phosphate isomerase
TDSAC_0409	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TDSAC_0415	COG2217	Heavy metal translocating P-type atpase
TDSAC_0416	COG4443	Transcriptional Coactivator p15 (PC4)
TDSAC_0419	COG0417	DNA replication proofreading
TDSAC_0420	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TDSAC_0423	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TDSAC_0424	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TDSAC_0425	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
TDSAC_0428	COG1592	Rubrerythrin
TDSAC_0432	COG0644	oxidoreductase
TDSAC_0437	COG2181	nitrate reductase activity
TDSAC_0437	COG0247	lactate metabolic process
TDSAC_0441	COG0493	'glutamate synthase
TDSAC_0441	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
TDSAC_0443	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TDSAC_0443	COG0425	Belongs to the sulfur carrier protein TusA family
TDSAC_0446	COG0739	heme binding
TDSAC_0447	COG0492	ferredoxin-NADP+ reductase activity
TDSAC_0453	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
TDSAC_0456	COG1227	inorganic diphosphatase activity
TDSAC_0457	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TDSAC_0458	COG3956	TIGRFAM MazG family protein
TDSAC_0459	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
TDSAC_0461	COG1098	S1 RNA binding domain
TDSAC_0462	COG0137	argininosuccinate synthase activity
TDSAC_0463	COG0165	Argininosuccinate lyase
TDSAC_0465	COG0601	transmembrane transport
TDSAC_0468	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TDSAC_0469	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TDSAC_0470	COG1144	Oxidoreductase
TDSAC_0471	COG0674	pyruvate-flavodoxin oxidoreductase activity
TDSAC_0472	COG1013	pyruvate-flavodoxin oxidoreductase activity
TDSAC_0473	COG0352	thiamine-phosphate diphosphorylase activity
TDSAC_0475	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TDSAC_0477	COG0049	tRNA binding
TDSAC_0478	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TDSAC_0480	COG0051	transcription antitermination factor activity, RNA binding
TDSAC_0481	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TDSAC_0482	COG0088	Forms part of the polypeptide exit tunnel
TDSAC_0483	COG0089	rRNA binding
TDSAC_0484	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TDSAC_0485	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TDSAC_0487	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TDSAC_0488	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TDSAC_0489	COG0255	Belongs to the universal ribosomal protein uL29 family
TDSAC_0490	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TDSAC_0491	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TDSAC_0492	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TDSAC_0494	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TDSAC_0495	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TDSAC_0496	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TDSAC_0497	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TDSAC_0498	COG0200	Binds to the 23S rRNA
TDSAC_0501	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TDSAC_0502	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TDSAC_0503	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TDSAC_0504	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TDSAC_0505	COG0202	RNA polymerase activity
TDSAC_0506	COG0203	ribosomal protein L17
TDSAC_0508	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TDSAC_0509	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TDSAC_0510	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TDSAC_0511	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TDSAC_0512	COG0588	phosphoglycerate mutase activity
TDSAC_0513	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TDSAC_0518	COG1902	pentaerythritol trinitrate reductase activity
TDSAC_0518	COG0446	pyridine nucleotide-disulphide oxidoreductase
TDSAC_0519	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TDSAC_0521	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TDSAC_0522	COG0250	Participates in transcription elongation, termination and antitermination
TDSAC_0523	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TDSAC_0524	COG0081	regulation of translation
TDSAC_0525	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TDSAC_0526	COG0222	ribosome binding
TDSAC_0527	COG0667	Aldo Keto reductase
TDSAC_0529	COG0840	transmembrane signaling receptor activity
TDSAC_0529	COG0840	transmembrane signaling receptor activity
TDSAC_0531	COG0631	protein serine/threonine phosphatase activity
TDSAC_0533	COG0028	Belongs to the TPP enzyme family
TDSAC_0534	COG0440	acetolactate synthase activity
TDSAC_0535	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TDSAC_0544	COG0438	transferase activity, transferring glycosyl groups
TDSAC_0546	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TDSAC_0547	COG0613	PHP domain protein
TDSAC_0549	COG1260	myo-inositol-1-phosphate synthase
TDSAC_0551	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TDSAC_0552	COG1185	polyribonucleotide nucleotidyltransferase activity
TDSAC_0553	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TDSAC_0556	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TDSAC_0557	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TDSAC_0560	COG0356	it plays a direct role in the translocation of protons across the membrane
TDSAC_0563	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TDSAC_0564	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TDSAC_0565	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TDSAC_0566	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TDSAC_0567	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TDSAC_0568	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TDSAC_0570	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TDSAC_0571	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TDSAC_0573	COG0195	Participates in both transcription termination and antitermination
TDSAC_0575	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TDSAC_0575	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TDSAC_0577	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TDSAC_0580	COG0196	riboflavin kinase activity
TDSAC_0583	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TDSAC_0585	COG0131	Imidazoleglycerol-phosphate dehydratase
TDSAC_0586	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TDSAC_0587	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TDSAC_0588	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TDSAC_0589	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TDSAC_0590	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TDSAC_0591	COG0138	bifunctional purine biosynthesis protein purh
TDSAC_0592	COG0151	Belongs to the GarS family
TDSAC_0593	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TDSAC_0595	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TDSAC_0596	COG0154	amidase activity
TDSAC_0599	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TDSAC_0600	COG1797	cobyrinic acid a,c-diamide synthase activity
TDSAC_0603	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TDSAC_0604	COG3260	NADH ubiquinone oxidoreductase 20
TDSAC_0605	COG0651	ATP synthesis coupled electron transport
TDSAC_0606	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TDSAC_0607	COG0437	4 iron, 4 sulfur cluster binding
TDSAC_0608	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
TDSAC_0608	COG3261	NADH dehydrogenase
TDSAC_0610	COG0649	NAD binding
TDSAC_0613	COG0385	Bile acid
TDSAC_0614	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TDSAC_0615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TDSAC_0616	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TDSAC_0618	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TDSAC_0619	COG0071	Belongs to the small heat shock protein (HSP20) family
TDSAC_0621	COG0497	DNA recombination
TDSAC_0623	COG2001	Belongs to the MraZ family
TDSAC_0624	COG0275	rRNA processing
TDSAC_0626	COG0768	penicillin binding
TDSAC_0627	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TDSAC_0628	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TDSAC_0631	COG0772	Belongs to the SEDS family
TDSAC_0632	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TDSAC_0633	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TDSAC_0634	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TDSAC_0635	COG1181	Belongs to the D-alanine--D-alanine ligase family
TDSAC_0638	COG3856	small basic protein
TDSAC_0639	COG0849	cell division
TDSAC_0640	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TDSAC_0642	COG1316	TRANSCRIPTIONal
TDSAC_0645	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TDSAC_0647	COG1077	Cell shape determining protein MreB Mrl
TDSAC_0650	COG0768	penicillin binding
TDSAC_0651	COG0850	regulation of cytokinetic process
TDSAC_0652	COG2894	cell division
TDSAC_0653	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TDSAC_0654	COG0772	Belongs to the SEDS family
TDSAC_0656	COG1199	ATP-dependent helicase activity
TDSAC_0657	COG2078	PFAM AMMECR1 domain protein
TDSAC_0657	COG3885	ferrous iron binding
TDSAC_0659	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TDSAC_0660	COG0072	phenylalanine-tRNA ligase activity
TDSAC_0660	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TDSAC_0662	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TDSAC_0662	COG1796	DNA polymerase
TDSAC_0665	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TDSAC_0666	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TDSAC_0667	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TDSAC_0668	COG0494	nUDIX hydrolase
TDSAC_0670	COG1012	belongs to the aldehyde dehydrogenase family
TDSAC_0671	COG0506	proline dehydrogenase activity
TDSAC_0680	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TDSAC_0683	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TDSAC_0684	COG0750	zinc metalloprotease
TDSAC_0685	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TDSAC_0686	COG0442	prolyl-tRNA aminoacylation
TDSAC_0687	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TDSAC_0688	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
TDSAC_0689	COG0375	protein maturation
TDSAC_0692	COG0018	arginyl-trna synthetase
TDSAC_0693	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TDSAC_0695	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TDSAC_0696	COG0505	Belongs to the CarA family
TDSAC_0697	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TDSAC_0699	COG0037	tRNA processing
TDSAC_0700	COG1811	Na channel or pump
TDSAC_0702	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TDSAC_0703	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TDSAC_0704	COG1045	serine acetyltransferase
TDSAC_0705	COG0215	cysteine-tRNA ligase activity
TDSAC_0706	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TDSAC_0708	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TDSAC_0713	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TDSAC_0714	COG0287	Prephenate dehydrogenase
TDSAC_0715	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TDSAC_0716	COG0617	tRNA 3'-terminal CCA addition
TDSAC_0718	COG0446	pyridine nucleotide-disulphide oxidoreductase
TDSAC_0719	COG1193	negative regulation of DNA recombination
TDSAC_0721	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TDSAC_0722	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TDSAC_0723	COG3854	ATPases associated with a variety of cellular activities
TDSAC_0724	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TDSAC_0725	COG0470	DNA polymerase III
TDSAC_0726	COG1774	PSP1 C-terminal conserved region
TDSAC_0727	COG4783	chaperone-mediated protein folding
TDSAC_0732	COG1278	Cold shock
TDSAC_0733	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TDSAC_0734	COG0653	protein targeting
TDSAC_0735	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TDSAC_0737	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TDSAC_0738	COG3959	Transketolase, thiamine diphosphate binding domain
TDSAC_0739	COG3958	Transketolase
TDSAC_0740	COG2884	Cell division ATP-binding protein ftsE
TDSAC_0741	COG2177	Part of the ABC transporter FtsEX involved in
TDSAC_0742	COG1573	uracil-dna glycosylase
TDSAC_0745	COG0564	pseudouridine synthase activity
TDSAC_0747	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
TDSAC_0750	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TDSAC_0763	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TDSAC_0764	COG0066	3-isopropylmalate dehydratase activity
TDSAC_0766	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TDSAC_0766	COG0674	pyruvate-flavodoxin oxidoreductase activity
TDSAC_0767	COG1013	pyruvate-flavodoxin oxidoreductase activity
TDSAC_0770	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TDSAC_0772	COG0409	Hydrogenase expression formation protein
TDSAC_0773	COG0298	carbon dioxide binding
TDSAC_0774	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TDSAC_0775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TDSAC_0776	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TDSAC_0779	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TDSAC_0780	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TDSAC_0784	COG1139	Iron-sulfur cluster binding protein
TDSAC_0785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TDSAC_0788	COG1522	sequence-specific DNA binding
TDSAC_0791	COG2084	Dehydrogenase
TDSAC_0798	COG4632	Exopolysaccharide biosynthesis protein
TDSAC_0798	COG5434	Belongs to the glycosyl hydrolase 28 family
TDSAC_0804	COG1122	ATPase activity
TDSAC_0806	COG0310	cobalt ion transport
TDSAC_0815	COG3706	GGDEF domain
TDSAC_0822	COG0444	Belongs to the ABC transporter superfamily
TDSAC_0824	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TDSAC_0825	COG0546	phosphoglycolate phosphatase activity
TDSAC_0830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TDSAC_0831	COG1297	OPT oligopeptide transporter protein
TDSAC_0834	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TDSAC_0835	COG1074	ATP-dependent DNA helicase activity
TDSAC_0839	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TDSAC_0840	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TDSAC_0841	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TDSAC_0841	COG2050	protein possibly involved in aromatic compounds catabolism
TDSAC_0846	COG2759	Belongs to the formate--tetrahydrofolate ligase family
TDSAC_0849	COG0242	peptide deformylase activity
TDSAC_0850	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TDSAC_0852	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TDSAC_0853	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TDSAC_0853	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TDSAC_0854	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TDSAC_0854	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TDSAC_0855	COG0460	homoserine dehydrogenase
TDSAC_0857	COG0497	DNA recombination
TDSAC_0858	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TDSAC_0859	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TDSAC_0860	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
TDSAC_0861	COG0142	geranyltranstransferase activity
TDSAC_0862	COG1196	nuclear chromosome segregation
TDSAC_0865	COG0552	protein localization to endoplasmic reticulum
TDSAC_0866	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TDSAC_0867	COG0228	four-way junction DNA binding
TDSAC_0868	COG1837	Belongs to the UPF0109 family
TDSAC_0869	COG0336	Belongs to the RNA methyltransferase TrmD family
TDSAC_0870	COG0335	large ribosomal subunit rRNA binding
TDSAC_0871	COG0681	Belongs to the peptidase S26 family
TDSAC_0873	COG0792	nuclease activity
TDSAC_0874	COG0606	chelatase, subunit chli
TDSAC_0875	COG0758	DNA mediated transformation
TDSAC_0876	COG0445	tRNA wobble uridine modification
TDSAC_0877	COG0720	synthase
TDSAC_0878	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TDSAC_0880	COG1648	precorrin-2 dehydrogenase activity
TDSAC_0880	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TDSAC_0881	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TDSAC_0883	COG0181	hydroxymethylbilane synthase activity
TDSAC_0885	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TDSAC_0886	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TDSAC_0889	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TDSAC_0890	COG0303	'Molybdopterin
TDSAC_0891	COG1910	domain protein
TDSAC_0892	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TDSAC_0893	COG0315	cyclic pyranopterin monophosphate synthase activity
TDSAC_0894	COG0521	Mo-molybdopterin cofactor biosynthetic process
TDSAC_0897	COG0284	orotidine-5'-phosphate decarboxylase activity
TDSAC_0898	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TDSAC_0902	COG0483	inositol monophosphate 1-phosphatase activity
TDSAC_0906	COG2414	aldehyde ferredoxin oxidoreductase
TDSAC_0907	COG1139	Iron-sulfur cluster binding protein
TDSAC_0909	COG2271	Major facilitator Superfamily
TDSAC_0915	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TDSAC_0916	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TDSAC_0917	COG0436	Aminotransferase
TDSAC_0925	COG3706	GGDEF domain
TDSAC_0926	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TDSAC_0927	COG0655	NAD(P)H dehydrogenase (quinone) activity
TDSAC_0930	COG1331	Highly conserved protein containing a thioredoxin domain
TDSAC_0932	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
TDSAC_0933	COG1687	branched-chain amino acid
TDSAC_0934	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TDSAC_0935	COG2814	Major facilitator Superfamily
TDSAC_0941	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TDSAC_0943	COG1473	amidohydrolase
TDSAC_0944	COG0252	asparaginase activity
TDSAC_0946	COG3706	GGDEF domain
TDSAC_0950	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TDSAC_0951	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TDSAC_0952	COG0305	Participates in initiation and elongation during chromosome replication
TDSAC_0954	COG0069	glutamate synthase activity
TDSAC_0954	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TDSAC_0955	COG0067	glutamate synthase
TDSAC_0963	COG0535	radical SAM domain protein
TDSAC_0964	COG1013	pyruvate-flavodoxin oxidoreductase activity
TDSAC_0967	COG2255	four-way junction helicase activity
TDSAC_0968	COG0632	four-way junction helicase activity
TDSAC_0969	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TDSAC_0970	COG0217	transcriptional regulatory protein
TDSAC_0971	COG0756	dUTP diphosphatase activity
TDSAC_0972	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TDSAC_0973	COG0268	Binds directly to 16S ribosomal RNA
TDSAC_0975	COG0658	competence protein
TDSAC_0976	COG1596	polysaccharide export
TDSAC_0976	COG1555	photosystem II stabilization
TDSAC_0977	COG0495	leucyl-tRNA aminoacylation
TDSAC_0979	COG3300	MHYT domain
TDSAC_0979	COG5001	Diguanylate cyclase
TDSAC_0988	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TDSAC_0991	COG1064	alcohol dehydrogenase
TDSAC_0995	COG0277	FAD linked oxidase domain protein
TDSAC_0996	COG3260	NADH ubiquinone oxidoreductase 20
TDSAC_0997	COG3261	NADH dehydrogenase
TDSAC_0997	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
TDSAC_0998	COG0651	ATP synthesis coupled electron transport
TDSAC_1001	COG0651	ATP synthesis coupled electron transport
TDSAC_1003	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TDSAC_1004	COG2244	polysaccharide biosynthetic process
TDSAC_1007	COG0859	PFAM glycosyl transferase family 9
TDSAC_1010	COG1968	undecaprenyl-diphosphatase activity
TDSAC_1013	COG0463	Glycosyl transferase, family 2
TDSAC_1015	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TDSAC_1025	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
TDSAC_1026	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
TDSAC_1027	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
TDSAC_1028	COG2205	protein histidine kinase activity
TDSAC_1029	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TDSAC_1030	COG2814	Major facilitator Superfamily
TDSAC_1033	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
TDSAC_1034	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TDSAC_1035	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TDSAC_1036	COG1027	Aspartate ammonia-lyase
TDSAC_1039	COG4624	Iron only hydrogenase large subunit, C-terminal domain
TDSAC_1039	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
TDSAC_1044	COG1278	Cold shock
TDSAC_1047	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TDSAC_1048	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TDSAC_1049	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TDSAC_1050	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TDSAC_1052	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TDSAC_1053	COG1872	DUF167
TDSAC_1055	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TDSAC_1056	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TDSAC_1057	COG0556	nucleotide-excision repair
TDSAC_1058	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TDSAC_1063	COG0121	glutamine amidotransferase
TDSAC_1067	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TDSAC_1067	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TDSAC_1069	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TDSAC_1071	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
TDSAC_1072	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TDSAC_1073	COG1758	RNA polymerase activity
TDSAC_1074	COG0194	GDP metabolic process
TDSAC_1076	COG0542	response to heat
TDSAC_1077	COG0789	Transcriptional regulator
TDSAC_1078	COG0484	heat shock protein binding
TDSAC_1079	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TDSAC_1080	COG0443	Heat shock 70 kDa protein
TDSAC_1081	COG0822	iron-sulfur transferase activity
TDSAC_1084	COG1132	(ABC) transporter
TDSAC_1090	COG1921	L-seryl-tRNASec selenium transferase activity
TDSAC_1093	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TDSAC_1099	COG5001	Diguanylate cyclase
TDSAC_1099	COG3300	MHYT domain
TDSAC_1100	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TDSAC_1102	COG2199	diguanylate cyclase activity
TDSAC_1104	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TDSAC_1106	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TDSAC_1110	COG0577	efflux transmembrane transporter activity
TDSAC_1110	COG1136	(ABC) transporter
TDSAC_1111	COG0577	efflux transmembrane transporter activity
TDSAC_1111	COG1136	(ABC) transporter
TDSAC_1112	COG0577	efflux transmembrane transporter activity
TDSAC_1112	COG1136	(ABC) transporter
TDSAC_1114	COG0437	4 iron, 4 sulfur cluster binding
TDSAC_1118	COG0437	4 iron, 4 sulfur cluster binding
TDSAC_1122	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TDSAC_1123	COG0095	Lipoate-protein ligase
TDSAC_1124	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TDSAC_1125	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TDSAC_1126	COG0509	glycine decarboxylation via glycine cleavage system
TDSAC_1128	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TDSAC_1129	COG1490	D-aminoacyl-tRNA deacylase activity
TDSAC_1130	COG0167	dihydroorotate dehydrogenase activity
TDSAC_1133	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TDSAC_1134	COG4399	Belongs to the UPF0754 family
TDSAC_1138	COG0497	DNA recombination
TDSAC_1140	COG0697	spore germination
TDSAC_1142	COG2247	cell wall binding repeat
TDSAC_1142	COG0860	N-Acetylmuramoyl-L-alanine amidase
TDSAC_1151	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
TDSAC_1153	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TDSAC_1153	COG0731	radical SAM domain protein
TDSAC_1154	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TDSAC_1155	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
TDSAC_1160	COG2193	ferroxidase activity
TDSAC_1162	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TDSAC_1163	COG0066	3-isopropylmalate dehydratase activity
TDSAC_1164	COG0473	3-isopropylmalate dehydrogenase activity
TDSAC_1165	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TDSAC_1169	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TDSAC_1170	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TDSAC_1171	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TDSAC_1173	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TDSAC_1175	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TDSAC_1177	COG0740	serine-type endopeptidase activity
TDSAC_1178	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TDSAC_1183	COG3300	MHYT domain
TDSAC_1183	COG5001	Diguanylate cyclase
TDSAC_1184	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TDSAC_1185	COG0708	Exodeoxyribonuclease III
TDSAC_1187	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TDSAC_1189	COG0535	radical SAM domain protein
TDSAC_1190	COG0113	porphobilinogen synthase activity
TDSAC_1192	COG0489	protein tyrosine kinase activity
TDSAC_1193	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
TDSAC_1197	COG0037	tRNA processing
TDSAC_1201	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TDSAC_1201	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TDSAC_1202	COG4956	integral membrane protein (PIN domain superfamily)
TDSAC_1203	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TDSAC_1210	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TDSAC_1211	COG2890	protein-(glutamine-N5) methyltransferase activity
TDSAC_1211	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TDSAC_1212	COG1802	Transcriptional regulator
TDSAC_1214	COG0805	protein transport
TDSAC_1216	COG1058	Belongs to the CinA family
TDSAC_1216	COG1546	Belongs to the CinA family
TDSAC_1217	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TDSAC_1219	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TDSAC_1221	COG0180	Tryptophanyl-tRNA synthetase
TDSAC_1223	COG1994	Peptidase M50
TDSAC_1225	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
TDSAC_1228	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TDSAC_1229	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TDSAC_1230	COG2848	UPF0210 protein
TDSAC_1232	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TDSAC_1233	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TDSAC_1236	COG1053	succinate dehydrogenase
TDSAC_1238	COG0477	Major facilitator Superfamily
TDSAC_1238	COG2814	Major facilitator Superfamily
TDSAC_1239	COG4178	(ABC) transporter
TDSAC_1241	COG3681	Belongs to the UPF0597 family
TDSAC_1242	COG2902	Dehydrogenase
TDSAC_1243	COG0251	oxidation-reduction process
TDSAC_1244	COG1760	l-serine dehydratase
TDSAC_1245	COG1760	l-serine dehydratase
TDSAC_1246	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TDSAC_1248	COG0148	phosphopyruvate hydratase activity
TDSAC_1249	COG0725	ABC transporter, periplasmic molybdate-binding protein
TDSAC_1250	COG4149	molybdate abc transporter
TDSAC_1251	COG3842	ATPase activity
TDSAC_1254	COG0735	belongs to the Fur family
TDSAC_1256	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TDSAC_1264	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TDSAC_1264	COG0519	Catalyzes the synthesis of GMP from XMP
TDSAC_1265	COG0516	GMP reductase activity
TDSAC_1266	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TDSAC_1267	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TDSAC_1267	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TDSAC_1269	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TDSAC_1270	COG0438	transferase activity, transferring glycosyl groups
TDSAC_1271	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TDSAC_1272	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TDSAC_1273	COG0085	RNA polymerase activity
TDSAC_1274	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TDSAC_1279	COG0668	transmembrane transport
TDSAC_1280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TDSAC_1283	COG3328	transposase activity
TDSAC_1284	COG1454	alcohol dehydrogenase
TDSAC_1288	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TDSAC_1290	COG0484	heat shock protein binding
TDSAC_1291	COG1420	regulation of RNA biosynthetic process
TDSAC_1292	COG0129	dihydroxy-acid dehydratase activity
TDSAC_1293	COG0799	negative regulation of ribosome biogenesis
TDSAC_1295	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TDSAC_1301	COG3328	transposase activity
TDSAC_1303	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
TDSAC_1304	COG3259	Nickel-dependent hydrogenase
TDSAC_1311	COG0525	valine-tRNA ligase activity
TDSAC_1312	COG0285	dihydrofolate synthase activity
TDSAC_1315	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TDSAC_1317	COG0140	phosphoribosyl-ATP diphosphatase activity
TDSAC_1317	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TDSAC_1318	COG0233	cytoplasmic translational termination
TDSAC_1319	COG0528	UMP kinase activity
TDSAC_1320	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TDSAC_1321	COG0052	Belongs to the universal ribosomal protein uS2 family
TDSAC_1324	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TDSAC_1326	COG0628	permease
TDSAC_1327	COG1131	(ABC) transporter
TDSAC_1329	COG0825	malonyl-CoA metabolic process
TDSAC_1330	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TDSAC_1332	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TDSAC_1333	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TDSAC_1334	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TDSAC_1335	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TDSAC_1336	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TDSAC_1337	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TDSAC_1338	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TDSAC_1342	COG2221	Nitrite and sulphite reductase 4Fe-4S
TDSAC_1343	COG2221	Nitrite and sulphite reductase 4Fe-4S
TDSAC_1344	COG2920	part of a sulfur-relay system
TDSAC_1345	COG0247	lactate metabolic process
TDSAC_1347	COG0037	tRNA processing
TDSAC_1348	COG0482	sulfurtransferase activity
TDSAC_1349	COG3118	belongs to the thioredoxin family
TDSAC_1350	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
TDSAC_1351	COG0210	DNA helicase
TDSAC_1352	COG0124	histidyl-tRNA synthetase
TDSAC_1353	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TDSAC_1357	COG4604	ABC transporter, ATP-binding protein
TDSAC_1358	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TDSAC_1361	COG2084	Dehydrogenase
TDSAC_1362	COG0765	amino acid transport
TDSAC_1363	COG0765	amino acid transport
TDSAC_1364	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TDSAC_1365	COG1126	abc transporter atp-binding protein
TDSAC_1366	COG0640	Transcriptional regulator
TDSAC_1367	COG1132	(ABC) transporter
TDSAC_1368	COG1519	Transferase
TDSAC_1369	COG1663	tetraacyldisaccharide 4'-kinase activity
TDSAC_1370	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TDSAC_1372	COG3409	Peptidoglycan-binding domain 1 protein
TDSAC_1372	COG0793	Belongs to the peptidase S41A family
TDSAC_1376	COG1940	carbohydrate kinase activity
TDSAC_1386	COG0385	Bile acid
TDSAC_1387	COG1720	tRNA m6t6A37 methyltransferase activity
TDSAC_1389	COG0848	biopolymer transport protein
TDSAC_1390	COG0811	peptide transport
TDSAC_1393	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TDSAC_1399	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
TDSAC_1400	COG0857	belongs to the CobB CobQ family
TDSAC_1401	COG0045	succinate-CoA ligase (ADP-forming) activity
TDSAC_1401	COG1042	CoA-binding domain protein
TDSAC_1401	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TDSAC_1402	COG0277	FAD linked oxidase domain protein
TDSAC_1404	COG0277	FAD linked oxidase domain protein
TDSAC_1405	COG2226	methyltransferase
TDSAC_1406	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TDSAC_1408	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TDSAC_1410	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TDSAC_1411	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TDSAC_1412	COG0416	fatty acid biosynthetic process
TDSAC_1413	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TDSAC_1416	COG0501	Belongs to the peptidase M48B family
TDSAC_1417	COG1902	pentaerythritol trinitrate reductase activity
TDSAC_1419	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
TDSAC_1421	COG0531	amino acid
TDSAC_1422	COG2271	Major facilitator Superfamily
TDSAC_1426	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TDSAC_1427	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TDSAC_1431	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TDSAC_1433	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TDSAC_1434	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TDSAC_1436	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TDSAC_1441	COG0745	RESPONSE REGULATOR receiver
TDSAC_1447	COG1918	ferrous iron import across plasma membrane
TDSAC_1447	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TDSAC_1448	COG0497	DNA recombination
TDSAC_1449	COG0602	queuosine metabolic process
TDSAC_1450	COG0720	synthase
TDSAC_1453	COG0670	Belongs to the BI1 family
TDSAC_1457	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TDSAC_1458	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TDSAC_1461	COG0704	Plays a role in the regulation of phosphate uptake
TDSAC_1462	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TDSAC_1463	COG0581	inorganic phosphate transmembrane transporter activity
TDSAC_1464	COG0573	inorganic phosphate transmembrane transporter activity
TDSAC_1468	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TDSAC_1469	COG0574	Belongs to the PEP-utilizing enzyme family
TDSAC_1469	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TDSAC_1470	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
TDSAC_1471	COG0751	glycine-tRNA ligase activity
TDSAC_1472	COG0752	glycyl-tRNA synthetase alpha subunit
TDSAC_1475	COG2814	Major facilitator Superfamily
TDSAC_1478	COG0504	CTP synthase activity
TDSAC_1479	COG1253	flavin adenine dinucleotide binding
TDSAC_1480	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TDSAC_1481	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TDSAC_1482	COG1480	7TM receptor with intracellular HD hydrolase
TDSAC_1483	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TDSAC_1484	COG0537	adenosine 5'-monophosphoramidase activity
TDSAC_1489	COG3883	PFAM NLP P60 protein
TDSAC_1489	COG0791	NLP P60 protein
TDSAC_1491	COG0586	Pfam SNARE associated Golgi protein
TDSAC_1493	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TDSAC_1494	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TDSAC_1497	COG1294	oxidase, subunit
TDSAC_1498	COG1271	oxidase subunit
TDSAC_1499	COG4106	trans-aconitate 2-methyltransferase activity
TDSAC_1500	COG1342	Belongs to the UPF0251 family
TDSAC_1502	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TDSAC_1503	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
TDSAC_1505	COG0513	Belongs to the DEAD box helicase family
TDSAC_1509	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TDSAC_1509	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TDSAC_1511	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TDSAC_1513	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TDSAC_1516	COG2909	trisaccharide binding
TDSAC_1519	COG1131	(ABC) transporter
TDSAC_1520	COG1131	(ABC) transporter
TDSAC_1523	COG0842	Transport permease protein
TDSAC_1532	COG2197	response regulator
TDSAC_1533	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TDSAC_1536	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TDSAC_1538	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
TDSAC_1540	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TDSAC_1543	COG1620	l-lactate permease
TDSAC_1555	COG0439	Biotin carboxylase
TDSAC_1556	COG0511	ligase activity, forming carbon-carbon bonds
TDSAC_1557	COG1151	hydroxylamine reductase activity
TDSAC_1558	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TDSAC_1559	COG0733	neurotransmitter:sodium symporter activity
TDSAC_1561	COG1966	Carbon starvation protein
TDSAC_1565	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TDSAC_1568	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TDSAC_1569	COG1233	COG1233 Phytoene dehydrogenase and related
TDSAC_1573	COG2046	Belongs to the sulfate adenylyltransferase family
TDSAC_1574	COG0563	adenylate kinase activity
TDSAC_1575	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TDSAC_1576	COG1164	Oligoendopeptidase f
TDSAC_1580	COG0489	protein tyrosine kinase activity
TDSAC_1581	COG1342	Belongs to the UPF0251 family
TDSAC_1582	COG2059	Chromate
TDSAC_1585	COG0840	transmembrane signaling receptor activity
TDSAC_1587	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TDSAC_1595	COG1660	Displays ATPase and GTPase activities
TDSAC_1596	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TDSAC_1599	COG0149	triose-phosphate isomerase activity
TDSAC_1599	COG0126	phosphoglycerate kinase activity
TDSAC_1600	COG0149	triose-phosphate isomerase activity
TDSAC_1603	COG1304	FMN binding
TDSAC_1606	COG1584	GPR1 FUN34 yaaH family protein
TDSAC_1607	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TDSAC_1609	COG1137	ATPase activity
TDSAC_1610	COG0571	ribonuclease III activity
TDSAC_1611	COG1984	allophanate hydrolase subunit 2
TDSAC_1612	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TDSAC_1613	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TDSAC_1614	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TDSAC_1615	COG1605	Chorismate mutase
TDSAC_1615	COG0077	Prephenate dehydratase
TDSAC_1620	COG0489	protein tyrosine kinase activity
TDSAC_1621	COG2894	cell division
TDSAC_1622	COG2204	response regulator
TDSAC_1626	COG1763	Mo-molybdopterin cofactor biosynthetic process
TDSAC_1628	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TDSAC_1629	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TDSAC_1630	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TDSAC_1631	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TDSAC_1633	COG0438	transferase activity, transferring glycosyl groups
TDSAC_1634	COG3660	Nucleoside-diphosphate-sugar epimerase
TDSAC_1635	COG0750	zinc metalloprotease
TDSAC_1638	COG0730	response to heat
TDSAC_1642	COG2197	response regulator
TDSAC_1646	COG0546	phosphoglycolate phosphatase activity
TDSAC_1647	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TDSAC_1648	COG0004	ammonium transporteR
TDSAC_1649	COG0347	Belongs to the P(II) protein family
TDSAC_1651	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TDSAC_1653	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TDSAC_1654	COG1766	The M ring may be actively involved in energy transduction
TDSAC_1656	COG1558	bacterial-type flagellum-dependent cell motility
TDSAC_1657	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
TDSAC_1659	COG4786	Flagellar basal body rod
TDSAC_1659	COG1256	bacterial-type flagellum assembly
TDSAC_1664	COG1706	bacterial-type flagellum-dependent cell motility
TDSAC_1665	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
TDSAC_1668	COG4786	Flagellar basal body rod
TDSAC_1673	COG5002	protein histidine kinase activity
TDSAC_1673	COG3850	Histidine kinase
TDSAC_1674	COG0745	RESPONSE REGULATOR receiver
TDSAC_1676	COG3290	protein histidine kinase activity
TDSAC_1676	COG0840	transmembrane signaling receptor activity
TDSAC_1678	COG2855	membrane
TDSAC_1679	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TDSAC_1680	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TDSAC_1682	COG0693	protein deglycase activity
TDSAC_1684	COG2239	Acts as a magnesium transporter
TDSAC_1686	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TDSAC_1688	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TDSAC_1689	COG1451	nucleotide metabolic process
TDSAC_1698	COG1321	iron dependent repressor
TDSAC_1699	COG1007	ATP synthesis coupled electron transport
TDSAC_1704	COG0651	ATP synthesis coupled electron transport
TDSAC_1705	COG0713	ATP synthesis coupled electron transport
TDSAC_1706	COG0839	Belongs to the complex I subunit 6 family
TDSAC_1707	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TDSAC_1708	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TDSAC_1709	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TDSAC_1710	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TDSAC_1711	COG0649	NAD binding
TDSAC_1712	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TDSAC_1713	COG0437	4 iron, 4 sulfur cluster binding
TDSAC_1715	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TDSAC_1716	COG0840	transmembrane signaling receptor activity
TDSAC_1719	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TDSAC_1723	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TDSAC_1724	COG0501	Belongs to the peptidase M48B family
TDSAC_1725	COG0302	gtp cyclohydrolase
TDSAC_1726	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TDSAC_1727	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TDSAC_1733	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TDSAC_1734	COG0616	signal peptide processing
TDSAC_1739	COG2814	Major facilitator Superfamily
TDSAC_1741	COG0589	response to stress
TDSAC_1742	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TDSAC_1744	COG0330	HflC and HflK could
TDSAC_1751	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TDSAC_1751	COG1918	ferrous iron import across plasma membrane
TDSAC_1753	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TDSAC_1758	COG1546	Belongs to the CinA family
TDSAC_1758	COG1058	Belongs to the CinA family
TDSAC_1759	COG0303	'Molybdopterin
TDSAC_1760	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TDSAC_1762	COG1254	Belongs to the acylphosphatase family
TDSAC_1763	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TDSAC_1763	COG1776	CheC inhibitor of MCP methylation
TDSAC_1764	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TDSAC_1766	COG1582	Flagellar protein (FlbD)
TDSAC_1767	COG4786	Flagellar basal body rod
TDSAC_1770	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TDSAC_1772	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
TDSAC_1780	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
TDSAC_1785	COG0105	UTP biosynthetic process
TDSAC_1786	COG1475	DNA binding
TDSAC_1787	COG1192	Involved in chromosome partitioning
TDSAC_1791	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TDSAC_1792	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TDSAC_1792	COG0512	Glutamine amidotransferase of anthranilate synthase
TDSAC_1793	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TDSAC_1794	COG0134	indole-3-glycerol-phosphate synthase activity
TDSAC_1795	COG0135	phosphoribosylanthranilate isomerase activity
TDSAC_1796	COG0133	tryptophan synthase activity
TDSAC_1797	COG0159	tryptophan synthase activity
TDSAC_1798	COG0517	IMP dehydrogenase activity
TDSAC_1798	COG0516	GMP reductase activity
TDSAC_1800	COG4149	molybdate abc transporter
TDSAC_1801	COG0725	ABC transporter, periplasmic molybdate-binding protein
TDSAC_1804	COG0357	Ribosomal RNA small subunit methyltransferase G
TDSAC_1806	COG0706	membrane insertase activity
TDSAC_1807	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TDSAC_1809	COG0230	Belongs to the bacterial ribosomal protein bL34 family