locus-tag	class	description
Thena_0002	COG0592	DNA-directed DNA polymerase activity
Thena_0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Thena_0005	COG0187	DNA topoisomerase II activity
Thena_0006	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Thena_0007	COG0142	geranyltranstransferase activity
Thena_0009	COG1191	sigma factor activity
Thena_0012	COG1360	Flagellar Motor Protein
Thena_0014	COG2201	protein-glutamate methylesterase activity
Thena_0016	COG1338	Plays a role in the flagellum-specific transport system
Thena_0017	COG2201	protein-glutamate methylesterase activity
Thena_0018	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Thena_0019	COG1776	CheC inhibitor of MCP methylation
Thena_0020	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Thena_0021	COG1987	bacterial-type flagellum assembly
Thena_0022	COG1684	flagellar biosynthetic protein fliR
Thena_0023	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Thena_0028	COG2198	Histidine kinase
Thena_0028	COG0643	Histidine kinase
Thena_0030	COG1815	bacterial-type flagellum-dependent cell motility
Thena_0031	COG0741	lytic transglycosylase activity
Thena_0032	COG5001	Diguanylate cyclase
Thena_0032	COG3300	MHYT domain
Thena_0033	COG2223	nitrite transmembrane transporter activity
Thena_0036	COG1151	hydroxylamine reductase activity
Thena_0038	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
Thena_0043	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Thena_0044	COG0459	protein refolding
Thena_0045	COG3290	protein histidine kinase activity
Thena_0045	COG0840	transmembrane signaling receptor activity
Thena_0046	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Thena_0049	COG0405	Gamma-glutamyltransferase
Thena_0050	COG0277	FAD linked oxidase domain protein
Thena_0051	COG0450	alkyl hydroperoxide reductase
Thena_0055	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Thena_0057	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Thena_0059	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Thena_0060	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Thena_0062	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Thena_0063	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Thena_0063	COG0517	IMP dehydrogenase activity
Thena_0064	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Thena_0066	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Thena_0068	COG1285	pathogenesis
Thena_0071	COG1067	ATP-dependent peptidase activity
Thena_0087	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Thena_0090	COG0419	ATPase involved in DNA repair
Thena_0091	COG0420	3'-5' exonuclease activity
Thena_0093	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
Thena_0094	COG1140	nitrate reductase beta subunit
Thena_0096	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
Thena_0097	COG2181	nitrate reductase activity
Thena_0098	COG0426	domain, Protein
Thena_0102	COG2226	methyltransferase
Thena_0105	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Thena_0106	COG0644	oxidoreductase
Thena_0108	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Thena_0114	COG0069	glutamate synthase activity
Thena_0114	COG0067	glutamate synthase
Thena_0114	COG0070	glutamate synthase
Thena_0115	COG0493	'glutamate synthase
Thena_0116	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Thena_0117	COG0511	ligase activity, forming carbon-carbon bonds
Thena_0118	COG0439	Biotin carboxylase
Thena_0119	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Thena_0120	COG0107	imidazoleglycerol-phosphate synthase activity
Thena_0121	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Thena_0122	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Thena_0124	COG1160	GTP binding
Thena_0125	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Thena_0126	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Thena_0130	COG0859	PFAM glycosyl transferase family 9
Thena_0131	COG0497	DNA recombination
Thena_0135	COG0411	ABC transporter
Thena_0136	COG0410	ABC transporter
Thena_0137	COG2033	superoxide reductase activity
Thena_0139	COG5298	Protein conserved in bacteria
Thena_0143	COG0497	DNA recombination
Thena_0144	COG0497	DNA recombination
Thena_0147	COG0347	Belongs to the P(II) protein family
Thena_0148	COG0019	diaminopimelate decarboxylase activity
Thena_0149	COG0726	polysaccharide deacetylase
Thena_0150	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Thena_0152	COG1418	mRNA catabolic process
Thena_0153	COG1692	metallophosphoesterase
Thena_0155	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Thena_0156	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Thena_0161	COG1674	ftsk spoiiie
Thena_0164	COG2046	Belongs to the sulfate adenylyltransferase family
Thena_0164	COG0529	Catalyzes the synthesis of activated sulfate
Thena_0166	COG0463	Glycosyl transferase, family 2
Thena_0166	COG1216	Glycosyl transferase, family 2
Thena_0168	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Thena_0174	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Thena_0176	COG1157	protein secretion by the type III secretion system
Thena_0177	COG1419	protein localization to endoplasmic reticulum
Thena_0178	COG0455	bacterial-type flagellum organization
Thena_0180	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Thena_0183	COG1215	transferase activity, transferring glycosyl groups
Thena_0184	COG2205	protein histidine kinase activity
Thena_0186	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Thena_0187	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Thena_0189	COG0281	malic enzyme
Thena_0193	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Thena_0194	COG0493	'glutamate synthase
Thena_0197	COG0481	GTPase activity
Thena_0198	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Thena_0201	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Thena_0201	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Thena_0202	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Thena_0203	COG0322	excinuclease ABC activity
Thena_0205	COG0739	heme binding
Thena_0206	COG0612	Peptidase, M16
Thena_0207	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Thena_0208	COG2359	stage V sporulation protein S
Thena_0210	COG1187	pseudouridine synthase activity
Thena_0211	COG0425	Belongs to the sulfur carrier protein TusA family
Thena_0212	COG1104	cysteine desulfurase activity
Thena_0214	COG0728	peptidoglycan biosynthetic process
Thena_0215	COG2359	stage V sporulation protein S
Thena_0217	COG0739	heme binding
Thena_0219	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Thena_0220	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Thena_0220	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Thena_0221	COG0084	hydrolase, TatD family'
Thena_0222	COG1355	regulation of microtubule-based process
Thena_0223	COG1324	tolerance protein
Thena_0224	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Thena_0227	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
Thena_0228	COG0083	homoserine kinase activity
Thena_0229	COG0527	aspartate kinase activity
Thena_0232	COG1105	Belongs to the carbohydrate kinase PfkB family
Thena_0234	COG0805	protein transport
Thena_0235	COG0746	molybdenum cofactor guanylyltransferase activity
Thena_0236	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Thena_0237	COG2252	PERMEase
Thena_0239	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Thena_0241	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Thena_0241	COG2199	diguanylate cyclase activity
Thena_0243	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Thena_0245	COG0583	DNA-binding transcription factor activity
Thena_0246	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Thena_0247	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Thena_0248	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Thena_0250	COG0438	transferase activity, transferring glycosyl groups
Thena_0252	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Thena_0253	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
Thena_0254	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Thena_0256	COG1309	transcriptional regulator
Thena_0257	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Thena_0258	COG0438	transferase activity, transferring glycosyl groups
Thena_0259	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Thena_0260	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Thena_0261	COG1793	dna ligase
Thena_0262	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Thena_0263	COG2199	diguanylate cyclase activity
Thena_0263	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Thena_0265	COG0012	GTP binding
Thena_0267	COG0360	Binds together with S18 to 16S ribosomal RNA
Thena_0268	COG0629	single-stranded DNA binding
Thena_0269	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Thena_0272	COG0358	DNA primase activity
Thena_0273	COG0802	atpase or kinase
Thena_0276	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Thena_0277	COG0193	aminoacyl-tRNA hydrolase activity
Thena_0279	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Thena_0279	COG0165	Argininosuccinate lyase
Thena_0280	COG0736	holo-[acyl-carrier-protein] synthase activity
Thena_0282	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Thena_0283	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Thena_0285	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Thena_0287	COG1966	Carbon starvation protein
Thena_0288	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Thena_0289	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Thena_0291	COG0719	Fe-S assembly protein
Thena_0292	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Thena_0294	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
Thena_0295	COG0543	2 iron, 2 sulfur cluster binding
Thena_0297	COG0590	tRNA wobble adenosine to inosine editing
Thena_0303	COG0402	S-adenosylhomocysteine deaminase activity
Thena_0304	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Thena_0308	COG0432	Pfam Uncharacterised protein family UPF0047
Thena_0312	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Thena_0313	COG0628	permease
Thena_0314	COG1012	belongs to the aldehyde dehydrogenase family
Thena_0315	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Thena_0315	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Thena_0318	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Thena_0321	COG3706	GGDEF domain
Thena_0326	COG0248	Ppx GppA phosphatase
Thena_0326	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Thena_0332	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
Thena_0333	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Thena_0334	COG0542	response to heat
Thena_0336	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
Thena_0338	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
Thena_0341	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Thena_0341	COG1042	CoA-binding domain protein
Thena_0341	COG0045	succinate-CoA ligase (ADP-forming) activity
Thena_0347	COG1929	Belongs to the glycerate kinase type-1 family
Thena_0348	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Thena_0351	COG0475	glutathione-regulated potassium exporter activity
Thena_0353	COG0009	L-threonylcarbamoyladenylate synthase
Thena_0354	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Thena_0357	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Thena_0360	COG0517	IMP dehydrogenase activity
Thena_0369	COG0662	Cupin 2, conserved barrel domain protein
Thena_0370	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Thena_0377	COG3858	chitin binding
Thena_0394	COG0463	Glycosyl transferase, family 2
Thena_0396	COG1216	Glycosyl transferase, family 2
Thena_0396	COG0438	transferase activity, transferring glycosyl groups
Thena_0402	COG0463	Glycosyl transferase, family 2
Thena_0411	COG1598	PFAM Uncharacterised protein family UPF0150
Thena_0422	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Thena_0423	COG1850	ribulose-bisphosphate carboxylase activity
Thena_0424	COG0572	uridine kinase
Thena_0425	COG3959	Transketolase, thiamine diphosphate binding domain
Thena_0426	COG3958	Transketolase
Thena_0428	COG0126	phosphoglycerate kinase activity
Thena_0429	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Thena_0430	COG0698	ribose 5-phosphate isomerase
Thena_0431	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Thena_0433	COG1937	Protein conserved in bacteria
Thena_0437	COG2217	Heavy metal translocating P-type atpase
Thena_0442	COG0417	DNA replication proofreading
Thena_0443	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Thena_0446	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Thena_0447	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Thena_0451	COG1592	Rubrerythrin
Thena_0457	COG1979	alcohol dehydrogenase
Thena_0461	COG0247	lactate metabolic process
Thena_0461	COG2181	nitrate reductase activity
Thena_0465	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Thena_0465	COG0493	'glutamate synthase
Thena_0467	COG0425	Belongs to the sulfur carrier protein TusA family
Thena_0469	COG0739	heme binding
Thena_0470	COG0492	ferredoxin-NADP+ reductase activity
Thena_0476	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Thena_0477	COG1570	exodeoxyribonuclease VII activity
Thena_0479	COG1227	inorganic diphosphatase activity
Thena_0480	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Thena_0481	COG3956	TIGRFAM MazG family protein
Thena_0482	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Thena_0484	COG1098	S1 RNA binding domain
Thena_0485	COG0137	argininosuccinate synthase activity
Thena_0486	COG0165	Argininosuccinate lyase
Thena_0488	COG0601	transmembrane transport
Thena_0491	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Thena_0492	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Thena_0493	COG1144	Oxidoreductase
Thena_0494	COG0674	pyruvate-flavodoxin oxidoreductase activity
Thena_0495	COG1013	pyruvate-flavodoxin oxidoreductase activity
Thena_0496	COG0352	thiamine-phosphate diphosphorylase activity
Thena_0498	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Thena_0500	COG0049	tRNA binding
Thena_0501	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Thena_0503	COG0051	transcription antitermination factor activity, RNA binding
Thena_0504	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Thena_0505	COG0088	Forms part of the polypeptide exit tunnel
Thena_0506	COG0089	rRNA binding
Thena_0507	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Thena_0508	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Thena_0510	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Thena_0511	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Thena_0512	COG0255	Belongs to the universal ribosomal protein uL29 family
Thena_0513	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Thena_0514	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Thena_0515	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Thena_0517	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Thena_0518	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Thena_0519	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Thena_0520	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Thena_0521	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Thena_0522	COG0200	Binds to the 23S rRNA
Thena_0525	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Thena_0526	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Thena_0527	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Thena_0528	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Thena_0529	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Thena_0530	COG0202	RNA polymerase activity
Thena_0531	COG0203	ribosomal protein L17
Thena_0532	COG0101	tRNA pseudouridine synthase activity
Thena_0533	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Thena_0534	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Thena_0535	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Thena_0536	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Thena_0537	COG0588	phosphoglycerate mutase activity
Thena_0538	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Thena_0543	COG1902	pentaerythritol trinitrate reductase activity
Thena_0549	COG1918	ferrous iron import across plasma membrane
Thena_0549	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Thena_0550	COG0497	DNA recombination
Thena_0552	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Thena_0553	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Thena_0554	COG0250	Participates in transcription elongation, termination and antitermination
Thena_0555	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Thena_0556	COG0081	regulation of translation
Thena_0557	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Thena_0558	COG0222	ribosome binding
Thena_0559	COG0667	Aldo Keto reductase
Thena_0561	COG0840	transmembrane signaling receptor activity
Thena_0561	COG3290	protein histidine kinase activity
Thena_0563	COG0631	protein serine/threonine phosphatase activity
Thena_0565	COG0028	Belongs to the TPP enzyme family
Thena_0566	COG0440	acetolactate synthase activity
Thena_0567	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Thena_0576	COG0438	transferase activity, transferring glycosyl groups
Thena_0579	COG0613	PHP domain protein
Thena_0583	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Thena_0584	COG1185	polyribonucleotide nucleotidyltransferase activity
Thena_0585	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Thena_0588	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Thena_0589	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Thena_0592	COG0356	it plays a direct role in the translocation of protons across the membrane
Thena_0595	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Thena_0596	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Thena_0598	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Thena_0599	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Thena_0600	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Thena_0602	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Thena_0603	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Thena_0605	COG0195	Participates in both transcription termination and antitermination
Thena_0607	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Thena_0609	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Thena_0610	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Thena_0611	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Thena_0612	COG0196	riboflavin kinase activity
Thena_0615	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Thena_0617	COG0131	Imidazoleglycerol-phosphate dehydratase
Thena_0618	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Thena_0619	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Thena_0620	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Thena_0621	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Thena_0622	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Thena_0623	COG0138	bifunctional purine biosynthesis protein purh
Thena_0624	COG0151	Belongs to the GarS family
Thena_0625	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Thena_0627	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Thena_0628	COG0154	amidase activity
Thena_0629	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Thena_0631	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Thena_0633	COG1797	cobyrinic acid a,c-diamide synthase activity
Thena_0637	COG3260	NADH ubiquinone oxidoreductase 20
Thena_0639	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Thena_0640	COG0437	4 iron, 4 sulfur cluster binding
Thena_0642	COG0649	NAD binding
Thena_0645	COG0385	Bile acid
Thena_0646	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Thena_0647	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Thena_0648	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Thena_0651	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Thena_0652	COG0071	Belongs to the small heat shock protein (HSP20) family
Thena_0654	COG0497	DNA recombination
Thena_0656	COG2001	Belongs to the MraZ family
Thena_0657	COG0275	rRNA processing
Thena_0659	COG0768	penicillin binding
Thena_0660	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Thena_0661	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Thena_0662	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Thena_0663	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Thena_0664	COG0772	Belongs to the SEDS family
Thena_0665	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Thena_0666	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Thena_0667	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Thena_0668	COG1181	Belongs to the D-alanine--D-alanine ligase family
Thena_0671	COG3856	small basic protein
Thena_0672	COG0849	cell division
Thena_0673	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Thena_0675	COG1316	TRANSCRIPTIONal
Thena_0678	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Thena_0680	COG1077	Cell shape determining protein MreB Mrl
Thena_0683	COG0768	penicillin binding
Thena_0684	COG0850	regulation of cytokinetic process
Thena_0685	COG2894	cell division
Thena_0686	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Thena_0687	COG0772	Belongs to the SEDS family
Thena_0689	COG1199	ATP-dependent helicase activity
Thena_0690	COG2078	PFAM AMMECR1 domain protein
Thena_0690	COG3885	ferrous iron binding
Thena_0692	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Thena_0693	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Thena_0693	COG0072	phenylalanine-tRNA ligase activity
Thena_0695	COG1796	DNA polymerase
Thena_0695	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Thena_0698	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Thena_0699	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Thena_0700	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Thena_0701	COG0494	nUDIX hydrolase
Thena_0702	COG4974	Belongs to the 'phage' integrase family
Thena_0703	COG1012	belongs to the aldehyde dehydrogenase family
Thena_0704	COG0506	proline dehydrogenase activity
Thena_0708	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Thena_0712	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Thena_0714	COG4589	Belongs to the CDS family
Thena_0715	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Thena_0716	COG0750	zinc metalloprotease
Thena_0718	COG0442	prolyl-tRNA aminoacylation
Thena_0719	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Thena_0720	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Thena_0721	COG0375	protein maturation
Thena_0724	COG0018	arginyl-trna synthetase
Thena_0725	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Thena_0726	COG0540	Belongs to the ATCase OTCase family
Thena_0727	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Thena_0728	COG0505	Belongs to the CarA family
Thena_0729	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Thena_0730	COG0037	tRNA processing
Thena_0731	COG1811	Na channel or pump
Thena_0733	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Thena_0734	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Thena_0735	COG1045	serine acetyltransferase
Thena_0736	COG0215	cysteine-tRNA ligase activity
Thena_0737	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Thena_0739	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Thena_0744	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Thena_0745	COG0287	Prephenate dehydrogenase
Thena_0746	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Thena_0749	COG0446	pyridine nucleotide-disulphide oxidoreductase
Thena_0752	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Thena_0753	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Thena_0754	COG3854	ATPases associated with a variety of cellular activities
Thena_0755	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Thena_0756	COG0470	DNA polymerase III
Thena_0757	COG1774	PSP1 C-terminal conserved region
Thena_0758	COG4783	chaperone-mediated protein folding
Thena_0759	COG0166	Belongs to the GPI family
Thena_0760	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Thena_0761	COG2801	Transposase and inactivated derivatives
Thena_0763	COG1278	Cold shock
Thena_0764	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Thena_0765	COG0653	protein targeting
Thena_0768	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Thena_0769	COG3959	Transketolase, thiamine diphosphate binding domain
Thena_0770	COG3958	Transketolase
Thena_0771	COG2884	Cell division ATP-binding protein ftsE
Thena_0772	COG2177	Part of the ABC transporter FtsEX involved in
Thena_0773	COG1573	uracil-dna glycosylase
Thena_0776	COG0564	pseudouridine synthase activity
Thena_0778	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
Thena_0780	COG0443	Heat shock 70 kDa protein
Thena_0781	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Thena_0782	COG0484	heat shock protein binding
Thena_0783	COG0789	Transcriptional regulator
Thena_0784	COG0542	response to heat
Thena_0786	COG0194	GDP metabolic process
Thena_0787	COG1758	RNA polymerase activity
Thena_0788	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Thena_0789	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Thena_0791	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Thena_0793	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Thena_0793	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Thena_0798	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Thena_0799	COG0556	nucleotide-excision repair
Thena_0800	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Thena_0801	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Thena_0803	COG1872	DUF167
Thena_0804	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Thena_0806	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Thena_0807	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Thena_0808	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Thena_0811	COG1278	Cold shock
Thena_0820	COG1518	maintenance of DNA repeat elements
Thena_0821	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Thena_0830	COG2814	Major facilitator Superfamily
Thena_0831	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
Thena_0832	COG2205	protein histidine kinase activity
Thena_0833	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
Thena_0834	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
Thena_0835	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Thena_0843	COG0463	Glycosyl transferase, family 2
Thena_0847	COG1968	undecaprenyl-diphosphatase activity
Thena_0850	COG0859	PFAM glycosyl transferase family 9
Thena_0853	COG2244	polysaccharide biosynthetic process
Thena_0854	COG0463	Glycosyl transferase, family 2
Thena_0856	COG1136	(ABC) transporter
Thena_0856	COG0577	efflux transmembrane transporter activity
Thena_0857	COG0277	FAD linked oxidase domain protein
Thena_0860	COG0667	Aldo Keto reductase
Thena_0868	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Thena_0873	COG0667	Aldo Keto reductase
Thena_0874	COG0789	Transcriptional regulator
Thena_0875	COG1012	belongs to the aldehyde dehydrogenase family
Thena_0877	COG1012	belongs to the aldehyde dehydrogenase family
Thena_0880	COG0495	leucyl-tRNA aminoacylation
Thena_0881	COG1555	photosystem II stabilization
Thena_0881	COG1596	polysaccharide export
Thena_0882	COG0658	competence protein
Thena_0884	COG0268	Binds directly to 16S ribosomal RNA
Thena_0885	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Thena_0886	COG0756	dUTP diphosphatase activity
Thena_0887	COG0217	transcriptional regulatory protein
Thena_0888	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Thena_0889	COG0632	four-way junction helicase activity
Thena_0890	COG2255	four-way junction helicase activity
Thena_0891	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Thena_0891	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Thena_0893	COG1013	pyruvate-flavodoxin oxidoreductase activity
Thena_0894	COG0535	radical SAM domain protein
Thena_0900	COG0067	glutamate synthase
Thena_0901	COG0069	glutamate synthase activity
Thena_0901	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Thena_0903	COG0305	Participates in initiation and elongation during chromosome replication
Thena_0904	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Thena_0905	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Thena_0908	COG3706	GGDEF domain
Thena_0910	COG1473	amidohydrolase
Thena_0912	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Thena_0916	COG0519	Catalyzes the synthesis of GMP from XMP
Thena_0916	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Thena_0918	COG2814	Major facilitator Superfamily
Thena_0919	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Thena_0921	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
Thena_0922	COG1396	sequence-specific DNA binding
Thena_0923	COG1331	Highly conserved protein containing a thioredoxin domain
Thena_0926	COG2814	Major facilitator Superfamily
Thena_0928	COG0655	NAD(P)H dehydrogenase (quinone) activity
Thena_0930	COG3706	GGDEF domain
Thena_0936	COG0436	Aminotransferase
Thena_0937	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Thena_0938	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Thena_0945	COG2059	Chromate
Thena_0946	COG2271	Major facilitator Superfamily
Thena_0948	COG1139	Iron-sulfur cluster binding protein
Thena_0949	COG2414	aldehyde ferredoxin oxidoreductase
Thena_0956	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Thena_0957	COG0284	orotidine-5'-phosphate decarboxylase activity
Thena_0960	COG0521	Mo-molybdopterin cofactor biosynthetic process
Thena_0961	COG0315	cyclic pyranopterin monophosphate synthase activity
Thena_0962	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Thena_0963	COG1910	domain protein
Thena_0964	COG0303	'Molybdopterin
Thena_0965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Thena_0968	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
Thena_0969	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Thena_0971	COG0181	hydroxymethylbilane synthase activity
Thena_0973	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Thena_0974	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Thena_0974	COG1648	precorrin-2 dehydrogenase activity
Thena_0976	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Thena_0977	COG0720	synthase
Thena_0978	COG0445	tRNA wobble uridine modification
Thena_0979	COG0758	DNA mediated transformation
Thena_0980	COG0606	chelatase, subunit chli
Thena_0981	COG0792	nuclease activity
Thena_0983	COG0681	Belongs to the peptidase S26 family
Thena_0984	COG0335	large ribosomal subunit rRNA binding
Thena_0985	COG0336	Belongs to the RNA methyltransferase TrmD family
Thena_0987	COG0228	four-way junction DNA binding
Thena_0988	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Thena_0989	COG0552	protein localization to endoplasmic reticulum
Thena_0993	COG0142	geranyltranstransferase activity
Thena_0994	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
Thena_0995	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Thena_0996	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Thena_0997	COG0497	DNA recombination
Thena_0999	COG0460	homoserine dehydrogenase
Thena_1000	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Thena_1000	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Thena_1001	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Thena_1001	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Thena_1002	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Thena_1004	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Thena_1005	COG0242	peptide deformylase activity
Thena_1007	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Thena_1011	COG2759	Belongs to the formate--tetrahydrofolate ligase family
Thena_1015	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Thena_1019	COG1074	ATP-dependent DNA helicase activity
Thena_1023	COG1297	OPT oligopeptide transporter protein
Thena_1024	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Thena_1025	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Thena_1027	COG0179	Fumarylacetoacetate (FAA) hydrolase
Thena_1029	COG0546	phosphoglycolate phosphatase activity
Thena_1030	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Thena_1032	COG0444	Belongs to the ABC transporter superfamily
Thena_1042	COG3383	formate dehydrogenase (NAD+) activity
Thena_1043	COG3706	GGDEF domain
Thena_1050	COG0310	cobalt ion transport
Thena_1052	COG1122	ATPase activity
Thena_1058	COG4632	Exopolysaccharide biosynthesis protein
Thena_1058	COG5434	Belongs to the glycosyl hydrolase 28 family
Thena_1060	COG2084	Dehydrogenase
Thena_1063	COG0651	ATP synthesis coupled electron transport
Thena_1064	COG0649	NAD binding
Thena_1066	COG0651	ATP synthesis coupled electron transport
Thena_1067	COG5001	Diguanylate cyclase
Thena_1069	COG1522	sequence-specific DNA binding
Thena_1072	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Thena_1073	COG1139	Iron-sulfur cluster binding protein
Thena_1077	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Thena_1081	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Thena_1082	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Thena_1083	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Thena_1084	COG0298	carbon dioxide binding
Thena_1085	COG0409	Hydrogenase expression formation protein
Thena_1087	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Thena_1090	COG1013	pyruvate-flavodoxin oxidoreductase activity
Thena_1091	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Thena_1091	COG0674	pyruvate-flavodoxin oxidoreductase activity
Thena_1093	COG0066	3-isopropylmalate dehydratase activity
Thena_1094	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Thena_1099	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Thena_1100	COG4943	cyclic-guanylate-specific phosphodiesterase activity
Thena_1101	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Thena_1113	COG1132	(ABC) transporter
Thena_1115	COG0822	iron-sulfur transferase activity
Thena_1117	COG0446	pyridine nucleotide-disulphide oxidoreductase
Thena_1119	COG1921	L-seryl-tRNASec selenium transferase activity
Thena_1122	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Thena_1126	COG3300	MHYT domain
Thena_1126	COG5001	Diguanylate cyclase
Thena_1127	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Thena_1128	COG3706	GGDEF domain
Thena_1131	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Thena_1135	COG1136	(ABC) transporter
Thena_1136	COG1136	(ABC) transporter
Thena_1136	COG0577	efflux transmembrane transporter activity
Thena_1137	COG0577	efflux transmembrane transporter activity
Thena_1137	COG1136	(ABC) transporter
Thena_1139	COG0437	4 iron, 4 sulfur cluster binding
Thena_1143	COG0437	4 iron, 4 sulfur cluster binding
Thena_1146	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Thena_1147	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Thena_1148	COG0095	Lipoate-protein ligase
Thena_1149	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Thena_1150	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Thena_1151	COG0509	glycine decarboxylation via glycine cleavage system
Thena_1153	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Thena_1154	COG1490	D-aminoacyl-tRNA deacylase activity
Thena_1155	COG0167	dihydroorotate dehydrogenase activity
Thena_1157	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Thena_1158	COG4399	Belongs to the UPF0754 family
Thena_1162	COG0497	DNA recombination
Thena_1164	COG0697	spore germination
Thena_1166	COG2247	cell wall binding repeat
Thena_1166	COG0860	N-Acetylmuramoyl-L-alanine amidase
Thena_1176	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Thena_1177	COG1362	aminopeptidase activity
Thena_1178	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Thena_1178	COG0731	radical SAM domain protein
Thena_1180	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Thena_1181	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Thena_1186	COG2193	ferroxidase activity
Thena_1188	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Thena_1189	COG0066	3-isopropylmalate dehydratase activity
Thena_1190	COG0473	3-isopropylmalate dehydrogenase activity
Thena_1191	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Thena_1195	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Thena_1196	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Thena_1197	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Thena_1199	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Thena_1201	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Thena_1203	COG0740	serine-type endopeptidase activity
Thena_1204	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Thena_1206	COG3706	GGDEF domain
Thena_1207	COG3300	MHYT domain
Thena_1207	COG5001	Diguanylate cyclase
Thena_1208	COG0840	transmembrane signaling receptor activity
Thena_1209	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Thena_1210	COG0708	Exodeoxyribonuclease III
Thena_1211	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Thena_1212	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Thena_1214	COG0535	radical SAM domain protein
Thena_1215	COG0113	porphobilinogen synthase activity
Thena_1217	COG0489	protein tyrosine kinase activity
Thena_1218	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Thena_1222	COG0037	tRNA processing
Thena_1226	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Thena_1226	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Thena_1227	COG4956	integral membrane protein (PIN domain superfamily)
Thena_1233	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Thena_1234	COG2890	protein-(glutamine-N5) methyltransferase activity
Thena_1234	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Thena_1235	COG1802	Transcriptional regulator
Thena_1237	COG0805	protein transport
Thena_1239	COG1058	Belongs to the CinA family
Thena_1239	COG1546	Belongs to the CinA family
Thena_1242	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Thena_1244	COG0180	Tryptophanyl-tRNA synthetase
Thena_1246	COG1994	Peptidase M50
Thena_1248	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
Thena_1251	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Thena_1252	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Thena_1253	COG2848	UPF0210 protein
Thena_1255	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Thena_1256	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Thena_1261	COG1053	succinate dehydrogenase
Thena_1264	COG0477	Major facilitator Superfamily
Thena_1264	COG2814	Major facilitator Superfamily
Thena_1265	COG4178	(ABC) transporter
Thena_1266	COG3706	GGDEF domain
Thena_1268	COG3681	Belongs to the UPF0597 family
Thena_1270	COG0251	oxidation-reduction process
Thena_1271	COG1760	l-serine dehydratase
Thena_1272	COG1760	l-serine dehydratase
Thena_1273	COG1113	amino acid transport
Thena_1274	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Thena_1275	COG0148	phosphopyruvate hydratase activity
Thena_1276	COG0725	ABC transporter, periplasmic molybdate-binding protein
Thena_1277	COG4149	molybdate abc transporter
Thena_1278	COG3842	ATPase activity
Thena_1279	COG1285	pathogenesis
Thena_1281	COG0735	belongs to the Fur family
Thena_1282	COG1942	4-Oxalocrotonate Tautomerase
Thena_1283	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Thena_1284	COG0237	dephospho-CoA kinase activity
Thena_1291	COG0519	Catalyzes the synthesis of GMP from XMP
Thena_1291	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Thena_1292	COG0516	GMP reductase activity
Thena_1293	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Thena_1294	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Thena_1294	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Thena_1296	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Thena_1297	COG0438	transferase activity, transferring glycosyl groups
Thena_1298	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Thena_1299	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Thena_1300	COG0085	RNA polymerase activity
Thena_1301	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Thena_1305	COG0668	transmembrane transport
Thena_1306	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Thena_1309	COG1454	alcohol dehydrogenase
Thena_1313	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Thena_1316	COG1420	regulation of RNA biosynthetic process
Thena_1317	COG0129	dihydroxy-acid dehydratase activity
Thena_1318	COG0799	negative regulation of ribosome biogenesis
Thena_1320	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Thena_1322	COG2920	part of a sulfur-relay system
Thena_1327	COG3259	Nickel-dependent hydrogenase
Thena_1334	COG0525	valine-tRNA ligase activity
Thena_1335	COG0285	dihydrofolate synthase activity
Thena_1339	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Thena_1341	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Thena_1341	COG0140	phosphoribosyl-ATP diphosphatase activity
Thena_1342	COG0233	cytoplasmic translational termination
Thena_1343	COG0528	UMP kinase activity
Thena_1344	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Thena_1345	COG0052	Belongs to the universal ribosomal protein uS2 family
Thena_1349	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Thena_1351	COG0628	permease
Thena_1352	COG1131	(ABC) transporter
Thena_1354	COG0825	malonyl-CoA metabolic process
Thena_1355	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Thena_1357	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Thena_1358	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Thena_1359	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Thena_1360	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Thena_1361	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Thena_1362	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Thena_1363	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Thena_1366	COG2221	Nitrite and sulphite reductase 4Fe-4S
Thena_1367	COG2221	Nitrite and sulphite reductase 4Fe-4S
Thena_1368	COG2920	part of a sulfur-relay system
Thena_1369	COG0247	lactate metabolic process
Thena_1371	COG0037	tRNA processing
Thena_1372	COG0482	sulfurtransferase activity
Thena_1373	COG3118	belongs to the thioredoxin family
Thena_1374	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Thena_1375	COG0210	DNA helicase
Thena_1377	COG0124	histidyl-tRNA synthetase
Thena_1378	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Thena_1381	COG0596	Alpha beta hydrolase
Thena_1383	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
Thena_1384	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Thena_1387	COG2084	Dehydrogenase
Thena_1388	COG0765	amino acid transport
Thena_1389	COG0765	amino acid transport
Thena_1390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Thena_1391	COG1126	abc transporter atp-binding protein
Thena_1392	COG0640	Transcriptional regulator
Thena_1393	COG1132	(ABC) transporter
Thena_1394	COG1519	Transferase
Thena_1395	COG1663	tetraacyldisaccharide 4'-kinase activity
Thena_1396	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Thena_1398	COG0793	Belongs to the peptidase S41A family
Thena_1398	COG3409	Peptidoglycan-binding domain 1 protein
Thena_1402	COG1940	carbohydrate kinase activity
Thena_1412	COG1720	tRNA m6t6A37 methyltransferase activity
Thena_1414	COG0848	biopolymer transport protein
Thena_1415	COG0811	peptide transport
Thena_1418	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Thena_1424	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
Thena_1425	COG0857	belongs to the CobB CobQ family
Thena_1426	COG0045	succinate-CoA ligase (ADP-forming) activity
Thena_1426	COG1042	CoA-binding domain protein
Thena_1426	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Thena_1427	COG0277	FAD linked oxidase domain protein
Thena_1429	COG0277	FAD linked oxidase domain protein
Thena_1430	COG2226	methyltransferase
Thena_1431	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Thena_1433	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Thena_1435	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Thena_1436	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Thena_1437	COG0416	fatty acid biosynthetic process
Thena_1438	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Thena_1441	COG0501	Belongs to the peptidase M48B family
Thena_1444	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Thena_1445	COG0531	amino acid
Thena_1446	COG2271	Major facilitator Superfamily
Thena_1447	COG0497	DNA recombination
Thena_1450	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Thena_1451	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Thena_1455	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Thena_1457	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Thena_1459	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Thena_1465	COG0745	RESPONSE REGULATOR receiver
Thena_1468	COG0602	queuosine metabolic process
Thena_1469	COG0720	synthase
Thena_1472	COG0670	Belongs to the BI1 family
Thena_1477	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Thena_1478	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Thena_1482	COG0704	Plays a role in the regulation of phosphate uptake
Thena_1483	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Thena_1484	COG0581	inorganic phosphate transmembrane transporter activity
Thena_1489	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Thena_1490	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Thena_1490	COG0574	Belongs to the PEP-utilizing enzyme family
Thena_1491	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Thena_1492	COG0751	glycine-tRNA ligase activity
Thena_1493	COG0752	glycyl-tRNA synthetase alpha subunit
Thena_1496	COG2814	Major facilitator Superfamily
Thena_1499	COG0504	CTP synthase activity
Thena_1500	COG4535	Mg2 and Co2 transporter CorC
Thena_1501	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Thena_1502	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Thena_1503	COG1480	7TM receptor with intracellular HD hydrolase
Thena_1504	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Thena_1505	COG0537	adenosine 5'-monophosphoramidase activity
Thena_1507	COG3307	-O-antigen
Thena_1508	COG2200	EAL domain
Thena_1511	COG1027	Aspartate ammonia-lyase
Thena_1512	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Thena_1513	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Thena_1514	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Thena_1519	COG4624	Iron only hydrogenase large subunit, C-terminal domain
Thena_1519	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Thena_1520	COG2801	Transposase and inactivated derivatives
Thena_1521	COG0791	NLP P60 protein
Thena_1521	COG3883	PFAM NLP P60 protein
Thena_1522	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Thena_1523	COG0586	Pfam SNARE associated Golgi protein
Thena_1525	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Thena_1526	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Thena_1529	COG1294	oxidase, subunit
Thena_1530	COG1271	oxidase subunit
Thena_1531	COG4106	trans-aconitate 2-methyltransferase activity
Thena_1532	COG1342	Belongs to the UPF0251 family
Thena_1534	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Thena_1535	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
Thena_1537	COG0513	Belongs to the DEAD box helicase family
Thena_1542	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Thena_1542	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Thena_1543	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Thena_1544	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Thena_1546	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Thena_1549	COG2909	trisaccharide binding
Thena_1551	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Thena_1552	COG1131	(ABC) transporter
Thena_1553	COG1131	(ABC) transporter
Thena_1555	COG0842	Transport permease protein
Thena_1564	COG2197	response regulator
Thena_1565	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Thena_1569	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
Thena_1574	COG1620	l-lactate permease
Thena_1583	COG0439	Biotin carboxylase
Thena_1584	COG0511	ligase activity, forming carbon-carbon bonds
Thena_1585	COG1151	hydroxylamine reductase activity
Thena_1586	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Thena_1589	COG1966	Carbon starvation protein
Thena_1593	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Thena_1596	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Thena_1597	COG1233	COG1233 Phytoene dehydrogenase and related
Thena_1602	COG0563	adenylate kinase activity
Thena_1603	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Thena_1604	COG1164	Oligoendopeptidase f
Thena_1605	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
Thena_1608	COG0489	protein tyrosine kinase activity
Thena_1610	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
Thena_1611	COG2059	Chromate
Thena_1614	COG0840	transmembrane signaling receptor activity
Thena_1616	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Thena_1624	COG1660	Displays ATPase and GTPase activities
Thena_1625	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Thena_1626	COG1481	regulation of sporulation
Thena_1628	COG0126	phosphoglycerate kinase activity
Thena_1628	COG0149	triose-phosphate isomerase activity
Thena_1629	COG0149	triose-phosphate isomerase activity
Thena_1632	COG1304	FMN binding
Thena_1636	COG1584	GPR1 FUN34 yaaH family protein
Thena_1637	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Thena_1639	COG1137	ATPase activity
Thena_1640	COG0571	ribonuclease III activity
Thena_1641	COG1984	allophanate hydrolase subunit 2
Thena_1642	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Thena_1643	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Thena_1644	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Thena_1645	COG1605	Chorismate mutase
Thena_1645	COG0077	Prephenate dehydratase
Thena_1651	COG0489	protein tyrosine kinase activity
Thena_1653	COG2204	response regulator
Thena_1657	COG1763	Mo-molybdopterin cofactor biosynthetic process
Thena_1659	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Thena_1660	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Thena_1661	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Thena_1664	COG0438	transferase activity, transferring glycosyl groups
Thena_1665	COG3660	Nucleoside-diphosphate-sugar epimerase
Thena_1666	COG0750	zinc metalloprotease
Thena_1669	COG0730	response to heat
Thena_1673	COG2197	response regulator
Thena_1677	COG0546	phosphoglycolate phosphatase activity
Thena_1678	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Thena_1679	COG0004	ammonium transporteR
Thena_1680	COG0004	ammonium transporteR
Thena_1681	COG0347	Belongs to the P(II) protein family
Thena_1682	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Thena_1683	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Thena_1685	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Thena_1686	COG1766	The M ring may be actively involved in energy transduction
Thena_1688	COG1558	bacterial-type flagellum-dependent cell motility
Thena_1689	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
Thena_1691	COG1256	bacterial-type flagellum assembly
Thena_1691	COG4786	Flagellar basal body rod
Thena_1696	COG1706	bacterial-type flagellum-dependent cell motility
Thena_1697	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
Thena_1700	COG4786	Flagellar basal body rod
Thena_1705	COG5002	protein histidine kinase activity
Thena_1705	COG3850	Histidine kinase
Thena_1706	COG0745	RESPONSE REGULATOR receiver
Thena_1707	COG3290	protein histidine kinase activity
Thena_1707	COG0840	transmembrane signaling receptor activity
Thena_1709	COG2855	membrane
Thena_1709	COG2855	membrane
Thena_1710	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Thena_1711	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Thena_1713	COG0693	protein deglycase activity
Thena_1715	COG2239	Acts as a magnesium transporter
Thena_1716	COG1914	H( )-stimulated, divalent metal cation uptake system
Thena_1717	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Thena_1720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Thena_1726	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Thena_1731	COG1337	RAMP superfamily
Thena_1733	COG1353	crispr-associated protein
Thena_1742	COG1321	iron dependent repressor
Thena_1743	COG1007	ATP synthesis coupled electron transport
Thena_1748	COG0651	ATP synthesis coupled electron transport
Thena_1749	COG0713	ATP synthesis coupled electron transport
Thena_1750	COG0839	Belongs to the complex I subunit 6 family
Thena_1751	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Thena_1752	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Thena_1753	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Thena_1754	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Thena_1755	COG0649	NAD binding
Thena_1756	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Thena_1757	COG0437	4 iron, 4 sulfur cluster binding
Thena_1759	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Thena_1763	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Thena_1767	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Thena_1768	COG0501	Belongs to the peptidase M48B family
Thena_1769	COG0302	gtp cyclohydrolase
Thena_1770	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Thena_1771	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Thena_1778	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Thena_1779	COG0616	signal peptide processing
Thena_1783	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Thena_1784	COG2814	Major facilitator Superfamily
Thena_1785	COG1566	PFAM secretion protein HlyD family protein
Thena_1786	COG0589	response to stress
Thena_1787	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Thena_1789	COG0330	HflC and HflK could
Thena_1796	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Thena_1796	COG1918	ferrous iron import across plasma membrane
Thena_1798	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Thena_1803	COG1058	Belongs to the CinA family
Thena_1803	COG1546	Belongs to the CinA family
Thena_1805	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Thena_1807	COG1254	Belongs to the acylphosphatase family
Thena_1808	COG1776	CheC inhibitor of MCP methylation
Thena_1808	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Thena_1809	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Thena_1811	COG1582	Flagellar protein (FlbD)
Thena_1812	COG4786	Flagellar basal body rod
Thena_1815	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Thena_1817	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Thena_1826	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Thena_1828	COG2226	methyltransferase
Thena_1833	COG0105	UTP biosynthetic process
Thena_1834	COG1475	DNA binding
Thena_1835	COG1192	Involved in chromosome partitioning
Thena_1839	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Thena_1839	COG0512	Glutamine amidotransferase of anthranilate synthase
Thena_1840	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Thena_1841	COG0134	indole-3-glycerol-phosphate synthase activity
Thena_1842	COG0135	phosphoribosylanthranilate isomerase activity
Thena_1843	COG0133	tryptophan synthase activity
Thena_1844	COG0159	tryptophan synthase activity
Thena_1845	COG0516	GMP reductase activity
Thena_1845	COG0517	IMP dehydrogenase activity
Thena_1847	COG4149	molybdate abc transporter
Thena_1848	COG0725	ABC transporter, periplasmic molybdate-binding protein
Thena_1849	COG0357	Ribosomal RNA small subunit methyltransferase G
Thena_1851	COG0706	membrane insertase activity
Thena_1852	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Thena_1854	COG0230	Belongs to the bacterial ribosomal protein bL34 family