locus-tag	class	description
TDMWS_00020	COG0546	phosphoglycolate phosphatase activity
TDMWS_00040	COG2188	Transcriptional regulator
TDMWS_00070	COG5001	Diguanylate cyclase
TDMWS_00100	COG2226	methyltransferase
TDMWS_00120	COG0577	efflux transmembrane transporter activity
TDMWS_00120	COG1136	(ABC) transporter
TDMWS_00170	COG1830	Aldolase
TDMWS_00180	COG1465	3-dehydroquinate synthase
TDMWS_00190	COG1605	Chorismate mutase
TDMWS_00190	COG0077	Prephenate dehydratase
TDMWS_00200	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TDMWS_00210	COG0287	Prephenate dehydrogenase
TDMWS_00210	COG1605	Chorismate mutase
TDMWS_00220	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TDMWS_00240	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TDMWS_00250	COG0134	indole-3-glycerol-phosphate synthase activity
TDMWS_00260	COG0135	phosphoribosylanthranilate isomerase activity
TDMWS_00270	COG0133	tryptophan synthase activity
TDMWS_00280	COG0159	tryptophan synthase activity
TDMWS_00300	COG0174	glutamine synthetase
TDMWS_00310	COG1815	bacterial-type flagellum-dependent cell motility
TDMWS_00320	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TDMWS_00330	COG1489	DNA binding
TDMWS_00360	COG1355	regulation of microtubule-based process
TDMWS_00370	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TDMWS_00380	COG0148	phosphopyruvate hydratase activity
TDMWS_00400	COG2835	tetraacyldisaccharide 4'-kinase activity
TDMWS_00410	COG0084	hydrolase, TatD family'
TDMWS_00430	COG1469	GTP cyclohydrolase I activity
TDMWS_00460	COG1129	ABC transporter
TDMWS_00470	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
TDMWS_00480	COG1079	Belongs to the binding-protein-dependent transport system permease family
TDMWS_00540	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TDMWS_00560	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TDMWS_00580	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TDMWS_00590	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TDMWS_00610	COG0772	Belongs to the SEDS family
TDMWS_00620	COG0768	penicillin binding
TDMWS_00640	COG1792	Involved in formation and maintenance of cell shape
TDMWS_00650	COG1077	Cell shape determining protein MreB Mrl
TDMWS_00660	COG1242	4 iron, 4 sulfur cluster binding
TDMWS_00690	COG0513	Belongs to the DEAD box helicase family
TDMWS_00700	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TDMWS_00710	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TDMWS_00720	COG1530	ribonuclease E activity
TDMWS_00740	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TDMWS_00760	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TDMWS_00780	COG4662	Binding-protein-dependent transport system inner membrane component
TDMWS_00790	COG1122	ATPase activity
TDMWS_00880	COG3108	Peptidase M15
TDMWS_00920	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TDMWS_00930	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TDMWS_00940	COG1459	type II secretion system
TDMWS_00950	COG0494	nUDIX hydrolase
TDMWS_00960	COG0488	(ABC) transporter
TDMWS_00980	COG1216	Glycosyl transferase, family 2
TDMWS_01020	COG0297	glycogen (starch) synthase activity
TDMWS_01050	COG0009	L-threonylcarbamoyladenylate synthase
TDMWS_01070	COG1546	Belongs to the CinA family
TDMWS_01080	COG0778	Nitroreductase
TDMWS_01100	COG4124	Belongs to the glycosyl hydrolase 26 family
TDMWS_01100	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
TDMWS_01110	COG0653	protein targeting
TDMWS_01120	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TDMWS_01140	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TDMWS_01160	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TDMWS_01170	COG0792	nuclease activity
TDMWS_01190	COG0335	large ribosomal subunit rRNA binding
TDMWS_01200	COG0336	Belongs to the RNA methyltransferase TrmD family
TDMWS_01200	COG4752	Belongs to the RNA methyltransferase TrmD family
TDMWS_01210	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TDMWS_01220	COG1837	Belongs to the UPF0109 family
TDMWS_01230	COG0228	four-way junction DNA binding
TDMWS_01240	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TDMWS_01250	COG0436	Aminotransferase
TDMWS_01260	COG2204	response regulator
TDMWS_01280	COG5002	protein histidine kinase activity
TDMWS_01290	COG1388	LysM domain
TDMWS_01290	COG0741	lytic transglycosylase activity
TDMWS_01300	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TDMWS_01320	COG1338	Plays a role in the flagellum-specific transport system
TDMWS_01360	COG1580	Controls the rotational direction of flagella during chemotaxis
TDMWS_01370	COG1360	Flagellar Motor Protein
TDMWS_01380	COG1360	Flagellar Motor Protein
TDMWS_01400	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TDMWS_01410	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TDMWS_01420	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TDMWS_01440	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TDMWS_01440	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TDMWS_01460	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TDMWS_01480	COG0709	Synthesizes selenophosphate from selenide and ATP
TDMWS_01490	COG0583	DNA-binding transcription factor activity
TDMWS_01520	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TDMWS_01530	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TDMWS_01540	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TDMWS_01570	COG0200	Binds to the 23S rRNA
TDMWS_01580	COG1841	ribosomal large subunit assembly
TDMWS_01590	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TDMWS_01600	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TDMWS_01610	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TDMWS_01620	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TDMWS_01630	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TDMWS_01650	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TDMWS_01660	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TDMWS_01670	COG0255	Belongs to the universal ribosomal protein uL29 family
TDMWS_01690	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TDMWS_01700	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TDMWS_01710	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TDMWS_01720	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TDMWS_01730	COG0089	rRNA binding
TDMWS_01740	COG0088	Forms part of the polypeptide exit tunnel
TDMWS_01750	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TDMWS_01760	COG0051	transcription antitermination factor activity, RNA binding
TDMWS_01770	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TDMWS_01800	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TDMWS_01810	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TDMWS_01820	COG0085	RNA polymerase activity
TDMWS_01840	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TDMWS_01850	COG0081	regulation of translation
TDMWS_01860	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TDMWS_01870	COG0250	Participates in transcription elongation, termination and antitermination
TDMWS_01900	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TDMWS_01910	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
TDMWS_01920	COG2890	protein-(glutamine-N5) methyltransferase activity
TDMWS_01930	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TDMWS_01940	COG0254	rRNA binding
TDMWS_01950	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TDMWS_01970	COG0356	it plays a direct role in the translocation of protons across the membrane
TDMWS_01990	COG5336	function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex
TDMWS_02000	COG1067	ATP-dependent peptidase activity
TDMWS_02030	COG3028	Belongs to the UPF0307 family
TDMWS_02040	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
TDMWS_02050	COG0542	response to heat
TDMWS_02060	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
TDMWS_02080	COG0446	pyridine nucleotide-disulphide oxidoreductase
TDMWS_02110	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TDMWS_02120	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TDMWS_02130	COG0798	PFAM Bile acid sodium symporter
TDMWS_02150	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TDMWS_02180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TDMWS_02190	COG0215	cysteine-tRNA ligase activity
TDMWS_02200	COG0321	lipoyl(octanoyl) transferase activity
TDMWS_02320	COG2894	cell division
TDMWS_02340	COG1342	Belongs to the UPF0251 family
TDMWS_02350	COG1342	Belongs to the UPF0251 family
TDMWS_02370	COG1131	(ABC) transporter
TDMWS_02410	COG0588	phosphoglycerate mutase activity
TDMWS_02420	COG1704	LemA family
TDMWS_02450	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TDMWS_02460	COG0154	amidase activity
TDMWS_02470	COG0482	sulfurtransferase activity
TDMWS_02480	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TDMWS_02500	COG1561	YicC-like family, N-terminal region
TDMWS_02510	COG2052	Domain of unknown function (DUF370)
TDMWS_02520	COG0194	GDP metabolic process
TDMWS_02530	COG0284	orotidine-5'-phosphate decarboxylase activity
TDMWS_02560	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
TDMWS_02580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TDMWS_02610	COG2203	Gaf domain
TDMWS_02610	COG5001	Diguanylate cyclase
TDMWS_02610	COG3706	GGDEF domain
TDMWS_02610	COG4251	negative regulation of phosphorylation
TDMWS_02640	COG0497	DNA recombination
TDMWS_02650	COG0543	2 iron, 2 sulfur cluster binding
TDMWS_02660	COG0167	dihydroorotate dehydrogenase activity
TDMWS_02720	COG0004	ammonium transporteR
TDMWS_02740	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
TDMWS_02750	COG0730	response to heat
TDMWS_02790	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TDMWS_02820	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TDMWS_02830	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TDMWS_02840	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TDMWS_02840	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TDMWS_02870	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TDMWS_02920	COG1475	DNA binding
TDMWS_02930	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TDMWS_02930	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TDMWS_02960	COG3264	Mechanosensitive ion channel
TDMWS_02960	COG1196	nuclear chromosome segregation
TDMWS_02990	COG0012	GTP binding
TDMWS_03030	COG0004	ammonium transporteR
TDMWS_03080	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TDMWS_03080	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TDMWS_03090	COG1774	PSP1 C-terminal conserved region
TDMWS_03100	COG0493	'glutamate synthase
TDMWS_03110	COG0543	2 iron, 2 sulfur cluster binding
TDMWS_03120	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TDMWS_03130	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TDMWS_03150	COG0084	hydrolase, TatD family'
TDMWS_03160	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TDMWS_03180	COG1025	Belongs to the peptidase M16 family
TDMWS_03220	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TDMWS_03220	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TDMWS_03230	COG1830	Aldolase
TDMWS_03240	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TDMWS_03270	COG0129	dihydroxy-acid dehydratase activity
TDMWS_03280	COG2177	Part of the ABC transporter FtsEX involved in
TDMWS_03290	COG2884	Cell division ATP-binding protein ftsE
TDMWS_03310	COG0521	Mo-molybdopterin cofactor biosynthetic process
TDMWS_03320	COG5002	protein histidine kinase activity
TDMWS_03330	COG0210	DNA helicase
TDMWS_03380	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TDMWS_03400	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TDMWS_03410	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
TDMWS_03430	COG2111	Na H antiporter
TDMWS_03430	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TDMWS_03440	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TDMWS_03450	COG3260	NADH ubiquinone oxidoreductase 20
TDMWS_03490	COG0693	protein deglycase activity
TDMWS_03500	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TDMWS_03510	COG3279	Response regulator of the LytR AlgR family
TDMWS_03530	COG0481	GTPase activity
TDMWS_03550	COG0606	chelatase, subunit chli
TDMWS_03560	COG0686	Belongs to the AlaDH PNT family
TDMWS_03610	COG2217	Heavy metal translocating P-type atpase
TDMWS_03630	COG2198	Histidine kinase
TDMWS_03630	COG0784	Response regulator, receiver
TDMWS_03630	COG2205	protein histidine kinase activity
TDMWS_03650	COG1053	succinate dehydrogenase
TDMWS_03660	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TDMWS_03700	COG0505	Belongs to the CarA family
TDMWS_03710	COG0826	peptidase U32
TDMWS_03730	COG0651	ATP synthesis coupled electron transport
TDMWS_03760	COG0651	ATP synthesis coupled electron transport
TDMWS_03770	COG3261	NADH dehydrogenase
TDMWS_03770	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
TDMWS_03780	COG3260	NADH ubiquinone oxidoreductase 20
TDMWS_03850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TDMWS_03870	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
TDMWS_03880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TDMWS_03900	COG0367	asparagine synthase
TDMWS_03920	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
TDMWS_03950	COG0750	zinc metalloprotease
TDMWS_03960	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TDMWS_03980	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TDMWS_04000	COG0528	UMP kinase activity
TDMWS_04040	COG0196	riboflavin kinase activity
TDMWS_04060	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TDMWS_04090	COG2814	Major facilitator Superfamily
TDMWS_04130	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TDMWS_04140	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TDMWS_04160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TDMWS_04180	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TDMWS_04190	COG1959	2 iron, 2 sulfur cluster binding
TDMWS_04200	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TDMWS_04240	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TDMWS_04250	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TDMWS_04320	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TDMWS_04340	COG0242	peptide deformylase activity
TDMWS_04350	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TDMWS_04400	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TDMWS_04410	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TDMWS_04420	COG0860	N-Acetylmuramoyl-L-alanine amidase
TDMWS_04430	COG1811	Na channel or pump
TDMWS_04470	COG1546	Belongs to the CinA family
TDMWS_04470	COG1058	Belongs to the CinA family
TDMWS_04570	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TDMWS_04590	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TDMWS_04600	COG0776	regulation of translation
TDMWS_04620	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TDMWS_04630	COG0539	negative regulation of cytoplasmic translation
TDMWS_04630	COG2183	response to ionizing radiation
TDMWS_04640	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TDMWS_04660	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TDMWS_04680	COG2920	part of a sulfur-relay system
TDMWS_04700	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TDMWS_04720	COG2046	Belongs to the sulfate adenylyltransferase family
TDMWS_04760	COG0446	pyridine nucleotide-disulphide oxidoreductase
TDMWS_04800	COG0437	4 iron, 4 sulfur cluster binding
TDMWS_04890	COG1012	belongs to the aldehyde dehydrogenase family
TDMWS_04900	COG1522	sequence-specific DNA binding
TDMWS_04910	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TDMWS_04920	COG1522	sequence-specific DNA binding
TDMWS_04930	COG0535	radical SAM domain protein
TDMWS_04940	COG0113	porphobilinogen synthase activity
TDMWS_04950	COG0535	radical SAM domain protein
TDMWS_04980	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TDMWS_04990	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TDMWS_05010	COG0138	bifunctional purine biosynthesis protein purh
TDMWS_05030	COG2200	EAL domain
TDMWS_05260	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TDMWS_05270	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TDMWS_05270	COG3116	cell division
TDMWS_05320	COG1191	sigma factor activity
TDMWS_05350	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TDMWS_05360	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TDMWS_05370	COG1684	flagellar biosynthetic protein fliR
TDMWS_05380	COG0037	tRNA processing
TDMWS_05390	COG1758	RNA polymerase activity
TDMWS_05400	COG0484	heat shock protein binding
TDMWS_05410	COG0315	cyclic pyranopterin monophosphate synthase activity
TDMWS_05420	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TDMWS_05430	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TDMWS_05440	COG0459	protein refolding
TDMWS_05490	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
TDMWS_05530	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
TDMWS_05540	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
TDMWS_05570	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TDMWS_05590	COG3634	alkyl hydroperoxide reductase activity
TDMWS_05640	COG0746	molybdenum cofactor guanylyltransferase activity
TDMWS_05640	COG0315	cyclic pyranopterin monophosphate synthase activity
TDMWS_05680	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TDMWS_05700	COG4214	carbohydrate transport
TDMWS_05710	COG0559	Belongs to the binding-protein-dependent transport system permease family
TDMWS_05720	COG2801	Transposase and inactivated derivatives
TDMWS_05760	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TDMWS_05770	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TDMWS_05780	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TDMWS_05790	COG0617	tRNA 3'-terminal CCA addition
TDMWS_05800	COG2204	response regulator
TDMWS_05810	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TDMWS_05820	COG0540	Belongs to the ATCase OTCase family
TDMWS_05830	COG4608	Belongs to the ABC transporter superfamily
TDMWS_05840	COG0444	Belongs to the ABC transporter superfamily
TDMWS_05850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TDMWS_05860	COG0601	transmembrane transport
TDMWS_05870	COG0747	negative chemotaxis
TDMWS_05890	COG1140	nitrate reductase beta subunit
TDMWS_05940	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TDMWS_05950	COG0187	DNA topoisomerase II activity
TDMWS_05970	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TDMWS_06020	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TDMWS_06030	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TDMWS_06080	COG1040	competence protein
TDMWS_06120	COG2226	methyltransferase
TDMWS_06130	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TDMWS_06140	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TDMWS_06150	COG0837	glucose binding
TDMWS_06170	COG2252	PERMEase
TDMWS_06180	COG0730	response to heat
TDMWS_06190	COG1122	ATPase activity
TDMWS_06220	COG0310	cobalt ion transport
TDMWS_06260	COG0560	Phosphoserine phosphatase
TDMWS_06260	COG3830	Belongs to the UPF0237 family
TDMWS_06290	COG2703	oxygen carrier activity
TDMWS_06300	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TDMWS_06320	COG0142	geranyltranstransferase activity
TDMWS_06330	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TDMWS_06340	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TDMWS_06370	COG2226	methyltransferase
TDMWS_06410	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TDMWS_06420	COG1522	sequence-specific DNA binding
TDMWS_06430	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TDMWS_06440	COG0432	Pfam Uncharacterised protein family UPF0047
TDMWS_06470	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TDMWS_06480	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TDMWS_06490	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TDMWS_06510	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TDMWS_06520	COG0072	phenylalanine-tRNA ligase activity
TDMWS_06520	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TDMWS_06550	COG0436	Aminotransferase
TDMWS_06560	COG0166	Belongs to the GPI family
TDMWS_06570	COG3852	Histidine kinase
TDMWS_06580	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TDMWS_06590	COG1074	ATP-dependent DNA helicase activity
TDMWS_06600	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
TDMWS_06650	COG0571	ribonuclease III activity
TDMWS_06660	COG0045	succinate-CoA ligase (ADP-forming) activity
TDMWS_06660	COG1042	CoA-binding domain protein
TDMWS_06660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TDMWS_06670	COG0857	belongs to the CobB CobQ family
TDMWS_06700	COG0330	HflC and HflK could
TDMWS_06710	COG0330	HflC and HflK could
TDMWS_06860	COG1047	Peptidyl-prolyl cis-trans
TDMWS_06910	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TDMWS_06920	COG1472	Belongs to the glycosyl hydrolase 3 family
TDMWS_06950	COG0765	amino acid transport
TDMWS_06960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TDMWS_06970	COG0765	amino acid transport
TDMWS_06980	COG1760	l-serine dehydratase
TDMWS_07000	COG0463	Glycosyl transferase, family 2
TDMWS_07010	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TDMWS_07020	COG3481	metal-dependent phosphohydrolase, HD sub domain
TDMWS_07040	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TDMWS_07040	COG0674	pyruvate-flavodoxin oxidoreductase activity
TDMWS_07050	COG1013	pyruvate-flavodoxin oxidoreductase activity
TDMWS_07070	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TDMWS_07080	COG0191	fructose-bisphosphate aldolase activity
TDMWS_07110	COG0720	synthase
TDMWS_07150	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TDMWS_07210	COG1749	Flagellar hook protein flgE
TDMWS_07220	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TDMWS_07230	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TDMWS_07240	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TDMWS_07310	COG4191	Histidine kinase
TDMWS_07350	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TDMWS_07380	COG0439	Biotin carboxylase
TDMWS_07390	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TDMWS_07420	COG0629	single-stranded DNA binding
TDMWS_07520	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
TDMWS_07560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TDMWS_07570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TDMWS_07580	COG1309	transcriptional regulator
TDMWS_07590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TDMWS_07600	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TDMWS_07630	COG1090	epimerase
TDMWS_07660	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
TDMWS_07690	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
TDMWS_07690	COG0778	Nitroreductase
TDMWS_07750	COG0501	Belongs to the peptidase M48B family
TDMWS_07760	COG2204	response regulator
TDMWS_07790	COG1971	Probably functions as a manganese efflux pump
TDMWS_07800	COG1166	arginine decarboxylase activity
TDMWS_07830	COG0693	protein deglycase activity
TDMWS_07840	COG0436	Aminotransferase
TDMWS_07860	COG0563	adenylate kinase activity
TDMWS_07870	COG0840	transmembrane signaling receptor activity
TDMWS_07920	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TDMWS_07940	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
TDMWS_07960	COG0347	Belongs to the P(II) protein family
TDMWS_08000	COG0456	acetyltransferase
TDMWS_08030	COG0535	radical SAM domain protein
TDMWS_08030	COG1433	Dinitrogenase iron-molybdenum cofactor
TDMWS_08060	COG3842	ATPase activity
TDMWS_08080	COG2814	Major facilitator Superfamily
TDMWS_08090	COG0861	Integral membrane protein TerC family
TDMWS_08150	COG1832	CoA-binding protein
TDMWS_08160	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TDMWS_08170	COG1091	dTDP-4-dehydrorhamnose reductase activity
TDMWS_08190	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TDMWS_08210	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TDMWS_08220	COG0116	Belongs to the methyltransferase superfamily
TDMWS_08220	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TDMWS_08240	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TDMWS_08250	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TDMWS_08280	COG2204	response regulator
TDMWS_08290	COG4191	Histidine kinase
TDMWS_08300	COG2855	membrane
TDMWS_08320	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TDMWS_08330	COG2003	Belongs to the UPF0758 family
TDMWS_08360	COG0495	leucyl-tRNA aminoacylation
TDMWS_08370	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TDMWS_08380	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TDMWS_08390	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TDMWS_08390	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TDMWS_08410	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TDMWS_08410	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TDMWS_08420	COG2131	deaminase
TDMWS_08430	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TDMWS_08440	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TDMWS_08490	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TDMWS_08510	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TDMWS_08520	COG0724	RNA recognition motif
TDMWS_08560	COG5002	protein histidine kinase activity
TDMWS_08560	COG2198	Histidine kinase
TDMWS_08560	COG0784	Response regulator, receiver
TDMWS_08570	COG2703	oxygen carrier activity
TDMWS_08580	COG3426	butyrate kinase activity
TDMWS_08590	COG0280	phosphate acetyltransferase
TDMWS_08610	COG0513	Belongs to the DEAD box helicase family
TDMWS_08620	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TDMWS_08630	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TDMWS_08640	COG1674	ftsk spoiiie
TDMWS_08720	COG2204	response regulator
TDMWS_08740	COG1222	aaa ATPase
TDMWS_08770	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TDMWS_08810	COG2861	carbohydrate metabolic process
TDMWS_08820	COG0793	Belongs to the peptidase S41A family
TDMWS_08850	COG2264	protein methyltransferase activity
TDMWS_08860	COG0765	amino acid transport
TDMWS_08870	COG0765	amino acid transport
TDMWS_08880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TDMWS_08900	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TDMWS_08910	COG0756	dUTP diphosphatase activity
TDMWS_08940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TDMWS_08950	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TDMWS_08960	COG1434	Gram-negative-bacterium-type cell wall biogenesis
TDMWS_09020	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TDMWS_09040	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TDMWS_09050	COG1643	Atp-dependent helicase
TDMWS_09060	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
TDMWS_09070	COG0424	maF-like protein
TDMWS_09080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TDMWS_09100	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TDMWS_09110	COG0151	Belongs to the GarS family
TDMWS_09120	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TDMWS_09130	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
TDMWS_09180	COG0437	4 iron, 4 sulfur cluster binding
TDMWS_09240	COG2221	Nitrite and sulphite reductase 4Fe-4S
TDMWS_09250	COG2221	Nitrite and sulphite reductase 4Fe-4S
TDMWS_09270	COG1797	cobyrinic acid a,c-diamide synthase activity
TDMWS_09320	COG0542	response to heat
TDMWS_09330	COG0564	pseudouridine synthase activity
TDMWS_09350	COG2176	DNA-directed DNA polymerase activity
TDMWS_09380	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TDMWS_09390	COG0442	prolyl-tRNA aminoacylation
TDMWS_09400	COG1570	exodeoxyribonuclease VII activity
TDMWS_09410	COG1722	exodeoxyribonuclease VII activity
TDMWS_09420	COG0142	geranyltranstransferase activity
TDMWS_09440	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TDMWS_09450	COG0351	phosphomethylpyrimidine kinase
TDMWS_09450	COG0352	thiamine-phosphate diphosphorylase activity
TDMWS_09470	COG2022	thiamine diphosphate biosynthetic process
TDMWS_09500	COG0352	thiamine-phosphate diphosphorylase activity
TDMWS_09530	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TDMWS_09600	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TDMWS_09640	COG1216	Glycosyl transferase, family 2
TDMWS_09700	COG3039	Transposase
TDMWS_09720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TDMWS_09740	COG0662	Cupin 2, conserved barrel domain protein
TDMWS_09740	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
TDMWS_09760	COG2001	Belongs to the MraZ family
TDMWS_09770	COG0275	rRNA processing
TDMWS_09800	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TDMWS_09810	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TDMWS_09840	COG0772	Belongs to the SEDS family
TDMWS_09860	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TDMWS_09870	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TDMWS_09890	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TDMWS_09900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TDMWS_09910	COG3459	Glycosyltransferase 36 associated
TDMWS_09960	COG1216	Glycosyl transferase, family 2
TDMWS_09990	COG1216	Glycosyl transferase, family 2
TDMWS_10000	COG1216	Glycosyl transferase, family 2
TDMWS_10000	COG0463	Glycosyl transferase, family 2
TDMWS_10010	COG2226	methyltransferase
TDMWS_10070	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TDMWS_10080	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TDMWS_10100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TDMWS_10110	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
TDMWS_10140	COG1785	Belongs to the alkaline phosphatase family
TDMWS_10160	COG2084	Dehydrogenase
TDMWS_10180	COG2204	response regulator
TDMWS_10190	COG0436	Aminotransferase
TDMWS_10200	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TDMWS_10280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TDMWS_10290	COG1187	pseudouridine synthase activity
TDMWS_10300	COG0525	valine-tRNA ligase activity
TDMWS_10310	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TDMWS_10310	COG1587	Uroporphyrinogen-III synthase
TDMWS_10320	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TDMWS_10330	COG2078	PFAM AMMECR1 domain protein
TDMWS_10350	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TDMWS_10370	COG0708	Exodeoxyribonuclease III
TDMWS_10380	COG1309	transcriptional regulator
TDMWS_10390	COG1690	Belongs to the RtcB family
TDMWS_10430	COG3852	Histidine kinase
TDMWS_10450	COG2878	Part of a membrane complex involved in electron transport
TDMWS_10450	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
TDMWS_10460	COG4657	Part of a membrane complex involved in electron transport
TDMWS_10470	COG4660	Part of a membrane complex involved in electron transport
TDMWS_10480	COG4659	FMN binding
TDMWS_10490	COG4658	electron transport chain
TDMWS_10530	COG0784	Response regulator, receiver
TDMWS_10530	COG2205	protein histidine kinase activity
TDMWS_10550	COG0251	oxidation-reduction process
TDMWS_10590	COG1127	ABC transporter
TDMWS_10600	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TDMWS_10630	COG1253	flavin adenine dinucleotide binding
TDMWS_10640	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TDMWS_10650	COG1138	Cytochrome C-type biogenesis protein
TDMWS_10680	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TDMWS_10760	COG0517	IMP dehydrogenase activity
TDMWS_10760	COG0516	GMP reductase activity
TDMWS_10770	COG0519	Catalyzes the synthesis of GMP from XMP
TDMWS_10780	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TDMWS_10790	COG0805	protein transport
TDMWS_10800	COG0131	Imidazoleglycerol-phosphate dehydratase
TDMWS_10820	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TDMWS_10850	COG3706	GGDEF domain
TDMWS_10900	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TDMWS_10910	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TDMWS_10920	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TDMWS_10970	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TDMWS_10980	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TDMWS_10990	COG4535	Mg2 and Co2 transporter CorC
TDMWS_11020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TDMWS_11060	COG1238	metal cluster binding
TDMWS_11070	COG0489	protein tyrosine kinase activity
TDMWS_11080	COG0741	lytic transglycosylase activity
TDMWS_11090	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TDMWS_11160	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
TDMWS_11170	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TDMWS_11180	COG3118	belongs to the thioredoxin family
TDMWS_11190	COG0492	ferredoxin-NADP+ reductase activity
TDMWS_11200	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TDMWS_11220	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TDMWS_11270	COG1294	oxidase, subunit
TDMWS_11280	COG1271	oxidase subunit
TDMWS_11350	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
TDMWS_11390	COG1132	(ABC) transporter
TDMWS_11400	COG0726	polysaccharide deacetylase
TDMWS_11400	COG1649	PFAM Uncharacterised BCR, COG1649
TDMWS_11430	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TDMWS_11440	COG0840	transmembrane signaling receptor activity
TDMWS_11450	COG0835	chemotaxis
TDMWS_11460	COG0840	transmembrane signaling receptor activity
TDMWS_11480	COG0745	RESPONSE REGULATOR receiver
TDMWS_11490	COG0643	Histidine kinase
TDMWS_11490	COG2198	Histidine kinase
TDMWS_11500	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TDMWS_11510	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
TDMWS_11530	COG2201	protein-glutamate methylesterase activity
TDMWS_11540	COG0745	RESPONSE REGULATOR receiver
TDMWS_11550	COG2198	Histidine kinase
TDMWS_11550	COG0643	Histidine kinase
TDMWS_11590	COG5002	protein histidine kinase activity
TDMWS_11590	COG2198	Histidine kinase
TDMWS_11590	COG0784	Response regulator, receiver
TDMWS_11600	COG5001	Diguanylate cyclase
TDMWS_11600	COG3300	MHYT domain
TDMWS_11610	COG1797	cobyrinic acid a,c-diamide synthase activity
TDMWS_11640	COG1120	ATPase activity
TDMWS_11650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TDMWS_11660	COG4822	anaerobic cobalamin biosynthetic process
TDMWS_11700	COG0463	Glycosyl transferase, family 2
TDMWS_11700	COG1216	Glycosyl transferase, family 2
TDMWS_11760	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TDMWS_11770	COG2233	PERMEase
TDMWS_11780	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TDMWS_11860	COG2943	transferase activity, transferring hexosyl groups
TDMWS_11880	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
TDMWS_11900	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TDMWS_11920	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TDMWS_11930	COG0702	epimerase
TDMWS_11970	COG4399	Belongs to the UPF0754 family
TDMWS_11980	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
TDMWS_12000	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TDMWS_12020	COG0477	Major facilitator Superfamily
TDMWS_12030	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TDMWS_12030	COG1918	ferrous iron import across plasma membrane
TDMWS_12070	COG0552	protein localization to endoplasmic reticulum
TDMWS_12090	COG2770	Histidine kinase
TDMWS_12090	COG3437	response regulator, receiver
TDMWS_12100	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TDMWS_12110	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TDMWS_12120	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TDMWS_12140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TDMWS_12150	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TDMWS_12160	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TDMWS_12180	COG0531	amino acid
TDMWS_12190	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TDMWS_12220	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TDMWS_12230	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TDMWS_12290	COG1192	Involved in chromosome partitioning
TDMWS_12300	COG0859	PFAM glycosyl transferase family 9
TDMWS_12320	COG0688	phosphatidylethanolamine metabolic process
TDMWS_12330	COG1183	phosphatidylcholine synthase activity
TDMWS_12340	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TDMWS_12350	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TDMWS_12370	COG0473	3-isopropylmalate dehydrogenase activity
TDMWS_12390	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TDMWS_12410	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TDMWS_12420	COG0420	3'-5' exonuclease activity
TDMWS_12430	COG0419	ATPase involved in DNA repair
TDMWS_12470	COG0544	peptidyl-prolyl cis-trans isomerase activity
TDMWS_12500	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TDMWS_12510	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
TDMWS_12540	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TDMWS_12550	COG0776	regulation of translation
TDMWS_12570	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TDMWS_12580	COG1610	YqeY-like protein
TDMWS_12590	COG1193	negative regulation of DNA recombination
TDMWS_12600	COG0358	DNA primase activity
TDMWS_12690	COG0484	heat shock protein binding
TDMWS_12700	COG0437	4 iron, 4 sulfur cluster binding
TDMWS_12700	COG3064	Membrane
TDMWS_12710	COG5557	Pfam Polysulphide reductase, NrfD
TDMWS_12730	COG2181	nitrate reductase activity
TDMWS_12740	COG0247	lactate metabolic process
TDMWS_12760	COG0745	RESPONSE REGULATOR receiver
TDMWS_12770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TDMWS_12770	COG4191	Histidine kinase
TDMWS_12780	COG1959	2 iron, 2 sulfur cluster binding
TDMWS_12790	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
TDMWS_12820	COG1994	Peptidase M50
TDMWS_12860	COG0729	surface antigen
TDMWS_12880	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TDMWS_12890	COG0305	Participates in initiation and elongation during chromosome replication
TDMWS_12900	COG0359	binds to the 23S rRNA
TDMWS_12920	COG0360	Binds together with S18 to 16S ribosomal RNA
TDMWS_12930	COG0037	tRNA processing
TDMWS_12950	COG0745	RESPONSE REGULATOR receiver
TDMWS_12970	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TDMWS_12980	COG1121	(ABC) transporter
TDMWS_12990	COG0803	Belongs to the bacterial solute-binding protein 9 family
TDMWS_13010	COG2853	Lipoprotein
TDMWS_13040	COG1127	ABC transporter
TDMWS_13050	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TDMWS_13090	COG0840	transmembrane signaling receptor activity
TDMWS_13130	COG2204	response regulator
TDMWS_13140	COG0658	competence protein
TDMWS_13140	COG2333	competence protein COMEC
TDMWS_13170	COG1309	transcriptional regulator
TDMWS_13220	COG0644	oxidoreductase
TDMWS_13340	COG0419	ATPase involved in DNA repair
TDMWS_13410	COG0617	tRNA 3'-terminal CCA addition
TDMWS_13440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TDMWS_13440	COG1042	CoA-binding domain protein
TDMWS_13440	COG0045	succinate-CoA ligase (ADP-forming) activity
TDMWS_13450	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TDMWS_13460	COG2217	Heavy metal translocating P-type atpase
TDMWS_13470	COG0070	glutamate synthase
TDMWS_13470	COG0069	glutamate synthase activity
TDMWS_13470	COG0067	glutamate synthase
TDMWS_13490	COG1045	serine acetyltransferase
TDMWS_13510	COG0019	diaminopimelate decarboxylase activity
TDMWS_13530	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TDMWS_13570	COG0765	amino acid transport
TDMWS_13590	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TDMWS_13590	COG0617	tRNA 3'-terminal CCA addition
TDMWS_13590	COG3620	sequence-specific DNA binding
TDMWS_13600	COG4974	Belongs to the 'phage' integrase family
TDMWS_13610	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TDMWS_13670	COG4181	ATPase activity
TDMWS_13690	COG0564	pseudouridine synthase activity
TDMWS_13700	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
TDMWS_13720	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TDMWS_13730	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TDMWS_13740	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TDMWS_13770	COG0326	Molecular chaperone. Has ATPase activity
TDMWS_13820	COG0375	protein maturation
TDMWS_13830	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
TDMWS_13850	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TDMWS_13910	COG0156	8-amino-7-oxononanoate synthase activity
TDMWS_13920	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
TDMWS_13950	COG0569	domain protein
TDMWS_13960	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TDMWS_13970	COG4172	Belongs to the ABC transporter superfamily
TDMWS_13980	COG4239	(ABC) transporter, permease
TDMWS_13990	COG4174	ABC transporter (Permease)
TDMWS_14000	COG4166	transmembrane transport
TDMWS_14010	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TDMWS_14020	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TDMWS_14030	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TDMWS_14040	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TDMWS_14090	COG1160	GTP binding
TDMWS_14110	COG1013	pyruvate-flavodoxin oxidoreductase activity
TDMWS_14120	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TDMWS_14120	COG0674	pyruvate-flavodoxin oxidoreductase activity
TDMWS_14130	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TDMWS_14150	COG0126	phosphoglycerate kinase activity
TDMWS_14170	COG0574	Belongs to the PEP-utilizing enzyme family
TDMWS_14170	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TDMWS_14180	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
TDMWS_14190	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
TDMWS_14190	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
TDMWS_14200	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TDMWS_14210	COG2201	protein-glutamate methylesterase activity
TDMWS_14220	COG0835	chemotaxis
TDMWS_14230	COG2198	Histidine kinase
TDMWS_14230	COG0643	Histidine kinase
TDMWS_14250	COG0840	transmembrane signaling receptor activity
TDMWS_14260	COG1560	Kdo2-lipid A biosynthetic process
TDMWS_14330	COG1151	hydroxylamine reductase activity
TDMWS_14340	COG2203	Gaf domain
TDMWS_14340	COG3706	GGDEF domain
TDMWS_14340	COG4251	negative regulation of phosphorylation
TDMWS_14340	COG5001	Diguanylate cyclase
TDMWS_14350	COG0318	PFAM AMP-dependent synthetase and ligase
TDMWS_14360	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TDMWS_14370	COG0010	Belongs to the arginase family
TDMWS_14400	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TDMWS_14440	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TDMWS_14450	COG1592	Rubrerythrin
TDMWS_14490	COG0646	methionine synthase
TDMWS_14490	COG1410	methionine synthase
TDMWS_14550	COG0698	ribose 5-phosphate isomerase
TDMWS_14570	COG1494	fructose-1,6-bisphosphatase
TDMWS_14590	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
TDMWS_14600	COG0268	Binds directly to 16S ribosomal RNA
TDMWS_14620	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TDMWS_14630	COG1943	Transposase
TDMWS_14660	COG0732	type I restriction modification DNA specificity domain
TDMWS_14670	COG3177	Filamentation induced by cAMP protein fic
TDMWS_14680	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TDMWS_14690	COG1132	(ABC) transporter
TDMWS_14700	COG0751	glycine-tRNA ligase activity
TDMWS_14710	COG0752	glycyl-tRNA synthetase alpha subunit
TDMWS_14720	COG1381	Involved in DNA repair and RecF pathway recombination
TDMWS_14740	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TDMWS_14760	COG0835	chemotaxis
TDMWS_14780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TDMWS_14810	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
TDMWS_14820	COG0058	SHG alpha-glucan phosphorylase activity
TDMWS_14830	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TDMWS_14850	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TDMWS_14860	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TDMWS_14890	COG0745	RESPONSE REGULATOR receiver
TDMWS_14930	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TDMWS_14940	COG0322	excinuclease ABC activity
TDMWS_14970	COG0859	PFAM glycosyl transferase family 9
TDMWS_15000	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TDMWS_15010	COG2204	response regulator
TDMWS_15070	COG0745	RESPONSE REGULATOR receiver
TDMWS_15090	COG0745	RESPONSE REGULATOR receiver
TDMWS_15100	COG2204	response regulator
TDMWS_15110	COG2204	response regulator
TDMWS_15120	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TDMWS_15130	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
TDMWS_15140	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TDMWS_15150	COG1648	precorrin-2 dehydrogenase activity
TDMWS_15150	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TDMWS_15160	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TDMWS_15170	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TDMWS_15190	COG0037	tRNA processing
TDMWS_15210	COG0330	HflC and HflK could
TDMWS_15220	COG2226	methyltransferase
TDMWS_15240	COG1177	transmembrane transport
TDMWS_15260	COG3842	ATPase activity
TDMWS_15280	COG0488	(ABC) transporter
TDMWS_15290	COG0765	amino acid transport
TDMWS_15300	COG1126	abc transporter atp-binding protein
TDMWS_15320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TDMWS_15370	COG4585	Histidine kinase
TDMWS_15420	COG0504	CTP synthase activity
TDMWS_15440	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
TDMWS_15490	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TDMWS_15500	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TDMWS_15510	COG1660	Displays ATPase and GTPase activities
TDMWS_15550	COG0747	negative chemotaxis
TDMWS_15560	COG0601	transmembrane transport
TDMWS_15580	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TDMWS_15600	COG1227	inorganic diphosphatase activity
TDMWS_15620	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TDMWS_15630	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TDMWS_15640	COG0440	acetolactate synthase activity
TDMWS_15650	COG0028	Belongs to the TPP enzyme family
TDMWS_15670	COG0546	phosphoglycolate phosphatase activity
TDMWS_15680	COG0318	PFAM AMP-dependent synthetase and ligase
TDMWS_15720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TDMWS_15730	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TDMWS_15750	COG0742	ribosomal rna small subunit methyltransferase
TDMWS_15760	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TDMWS_15860	COG1362	aminopeptidase activity
TDMWS_15870	COG1773	rubredoxin
TDMWS_15880	COG0539	negative regulation of cytoplasmic translation
TDMWS_15890	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TDMWS_15910	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TDMWS_16000	COG0534	Mate efflux family protein
TDMWS_16010	COG0527	aspartate kinase activity
TDMWS_16080	COG5000	phosphorelay sensor kinase activity
TDMWS_16110	COG0569	domain protein
TDMWS_16170	COG1309	transcriptional regulator
TDMWS_16180	COG1752	Esterase of the alpha-beta hydrolase superfamily
TDMWS_16190	COG3852	Histidine kinase
TDMWS_16240	COG0047	phosphoribosylformylglycinamidine synthase activity
TDMWS_16260	COG0590	tRNA wobble adenosine to inosine editing
TDMWS_16280	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TDMWS_16290	COG0280	phosphate acetyltransferase
TDMWS_16290	COG0857	belongs to the CobB CobQ family
TDMWS_16300	COG0247	lactate metabolic process
TDMWS_16310	COG0277	FAD linked oxidase domain protein
TDMWS_16320	COG1620	l-lactate permease
TDMWS_16350	COG4232	protein-disulfide reductase activity
TDMWS_16360	COG1272	protein, Hemolysin III
TDMWS_16390	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TDMWS_16410	COG0484	heat shock protein binding
TDMWS_16430	COG0719	Fe-S assembly protein
TDMWS_16450	COG2885	chlorophyll binding
TDMWS_16460	COG0823	Involved in the tonB-independent uptake of proteins
TDMWS_16530	COG1324	tolerance protein
TDMWS_16540	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TDMWS_16550	COG0343	queuine tRNA-ribosyltransferase activity
TDMWS_16580	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TDMWS_16590	COG0346	lactoylglutathione lyase activity
TDMWS_16600	COG0784	Response regulator, receiver
TDMWS_16600	COG2205	protein histidine kinase activity
TDMWS_16680	COG0492	ferredoxin-NADP+ reductase activity
TDMWS_16730	COG0101	tRNA pseudouridine synthase activity
TDMWS_16750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TDMWS_16750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TDMWS_16760	COG0450	alkyl hydroperoxide reductase
TDMWS_16780	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TDMWS_16820	COG0402	S-adenosylhomocysteine deaminase activity
TDMWS_16830	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TDMWS_16840	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TDMWS_16890	COG0409	Hydrogenase expression formation protein
TDMWS_16910	COG1181	Belongs to the D-alanine--D-alanine ligase family
TDMWS_16920	COG1519	Transferase
TDMWS_16940	COG0505	Belongs to the CarA family
TDMWS_17000	COG2204	response regulator
TDMWS_17010	COG4191	Histidine kinase
TDMWS_17020	COG1694	Mazg nucleotide pyrophosphohydrolase
TDMWS_17050	COG3706	GGDEF domain
TDMWS_17080	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TDMWS_17080	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TDMWS_17090	COG0517	IMP dehydrogenase activity
TDMWS_17090	COG0617	tRNA 3'-terminal CCA addition
TDMWS_17090	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TDMWS_17100	COG0802	atpase or kinase
TDMWS_17130	COG0538	isocitrate dehydrogenase activity
TDMWS_17150	COG0613	PHP domain protein
TDMWS_17160	COG0826	peptidase U32
TDMWS_17180	COG0516	GMP reductase activity
TDMWS_17180	COG0517	IMP dehydrogenase activity
TDMWS_17210	COG0436	Aminotransferase
TDMWS_17240	COG1283	sodium-dependent phosphate transmembrane transporter activity
TDMWS_17270	COG0840	transmembrane signaling receptor activity
TDMWS_17270	COG0840	transmembrane signaling receptor activity
TDMWS_17290	COG0165	Argininosuccinate lyase
TDMWS_17300	COG0137	argininosuccinate synthase activity
TDMWS_17330	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TDMWS_17340	COG1702	phosphate starvation-inducible protein PhoH
TDMWS_17360	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TDMWS_17370	COG5557	Pfam Polysulphide reductase, NrfD
TDMWS_17380	COG0437	4 iron, 4 sulfur cluster binding
TDMWS_17390	COG0243	molybdopterin cofactor binding
TDMWS_17410	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
TDMWS_17460	COG1468	defense response to virus
TDMWS_17460	COG1518	maintenance of DNA repeat elements
TDMWS_17470	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TDMWS_17560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TDMWS_17570	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
TDMWS_17580	COG0616	signal peptide processing
TDMWS_17590	COG0277	FAD linked oxidase domain protein
TDMWS_17600	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TDMWS_17610	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TDMWS_17620	COG3437	response regulator, receiver
TDMWS_17630	COG4999	Histidine kinase
TDMWS_17630	COG3850	Histidine kinase
TDMWS_17630	COG3437	response regulator, receiver
TDMWS_17630	COG2205	protein histidine kinase activity
TDMWS_17650	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TDMWS_17660	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TDMWS_17670	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TDMWS_17690	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TDMWS_17710	COG1136	(ABC) transporter
TDMWS_17720	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TDMWS_17740	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TDMWS_17750	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TDMWS_17760	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TDMWS_17770	COG3494	Protein of unknown function (DUF1009)
TDMWS_17790	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TDMWS_17810	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TDMWS_17840	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TDMWS_17880	COG4974	Belongs to the 'phage' integrase family
TDMWS_17890	COG3706	GGDEF domain
TDMWS_17920	COG0758	DNA mediated transformation
TDMWS_17920	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TDMWS_17970	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TDMWS_18000	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TDMWS_18010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TDMWS_18020	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TDMWS_18040	COG0632	four-way junction helicase activity
TDMWS_18050	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TDMWS_18060	COG0217	transcriptional regulatory protein
TDMWS_18070	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
TDMWS_18090	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TDMWS_18110	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
TDMWS_18130	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TDMWS_18140	COG0107	imidazoleglycerol-phosphate synthase activity
TDMWS_18170	COG4957	zinc ion binding
TDMWS_18180	COG1032	radical SAM domain protein
TDMWS_18210	COG3956	TIGRFAM MazG family protein
TDMWS_18220	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TDMWS_18230	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TDMWS_18240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TDMWS_18260	COG0285	dihydrofolate synthase activity
TDMWS_18300	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
TDMWS_18360	COG0446	pyridine nucleotide-disulphide oxidoreductase
TDMWS_18390	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
TDMWS_18400	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TDMWS_18420	COG1256	bacterial-type flagellum assembly
TDMWS_18420	COG4786	Flagellar basal body rod
TDMWS_18420	COG1256	bacterial-type flagellum assembly
TDMWS_18420	COG4786	Flagellar basal body rod
TDMWS_18440	COG1607	acyl-coa hydrolase
TDMWS_18460	COG1706	bacterial-type flagellum-dependent cell motility
TDMWS_18470	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
TDMWS_18500	COG4786	Flagellar basal body rod
TDMWS_18520	COG1686	Belongs to the peptidase S11 family
TDMWS_18550	COG0564	pseudouridine synthase activity
TDMWS_18600	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TDMWS_18610	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TDMWS_18620	COG0714	Associated with various cellular activities
TDMWS_18650	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
TDMWS_18670	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TDMWS_18680	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TDMWS_18690	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TDMWS_18690	COG0517	IMP dehydrogenase activity
TDMWS_18740	COG0438	transferase activity, transferring glycosyl groups
TDMWS_18760	COG0438	transferase activity, transferring glycosyl groups
TDMWS_18790	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TDMWS_18990	COG0574	Belongs to the PEP-utilizing enzyme family
TDMWS_18990	COG3848	Pyruvate phosphate dikinase
TDMWS_19000	COG2204	response regulator
TDMWS_19030	COG0730	response to heat
TDMWS_19070	COG2204	response regulator
TDMWS_19090	COG2204	response regulator
TDMWS_19120	COG1178	ABC-type Fe3 transport system permease component
TDMWS_19130	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
TDMWS_19190	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TDMWS_19200	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TDMWS_19210	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TDMWS_19220	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TDMWS_19250	COG0589	response to stress
TDMWS_19280	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TDMWS_19300	COG0674	pyruvate-flavodoxin oxidoreductase activity
TDMWS_19300	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TDMWS_19330	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TDMWS_19360	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TDMWS_19370	COG0736	holo-[acyl-carrier-protein] synthase activity
TDMWS_19390	COG0195	Participates in both transcription termination and antitermination
TDMWS_19400	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TDMWS_19420	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TDMWS_19430	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TDMWS_19440	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TDMWS_19450	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TDMWS_19480	COG4969	Belongs to the N-Me-Phe pilin family
TDMWS_19500	COG3437	response regulator, receiver
TDMWS_19550	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TDMWS_19580	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TDMWS_19590	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TDMWS_19600	COG2210	Belongs to the sulfur carrier protein TusA family
TDMWS_19610	COG2193	ferroxidase activity
TDMWS_19630	COG0640	Transcriptional regulator
TDMWS_19640	COG1538	Outer membrane efflux protein
TDMWS_19650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TDMWS_19670	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TDMWS_19680	COG1027	Aspartate ammonia-lyase
TDMWS_19690	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TDMWS_19760	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TDMWS_19760	COG1328	CTP reductase activity
TDMWS_19770	COG0535	radical SAM domain protein
TDMWS_19780	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TDMWS_19790	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TDMWS_19800	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TDMWS_19810	COG1692	metallophosphoesterase
TDMWS_19850	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TDMWS_19860	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TDMWS_19880	COG0850	regulation of cytokinetic process
TDMWS_19890	COG1739	Uncharacterized protein family UPF0029
TDMWS_19900	COG0135	phosphoribosylanthranilate isomerase activity
TDMWS_19930	COG1846	Transcriptional regulator
TDMWS_19950	COG0252	asparaginase activity
TDMWS_19960	COG4999	Histidine kinase
TDMWS_19960	COG3850	Histidine kinase
TDMWS_19960	COG3437	response regulator, receiver
TDMWS_19960	COG2205	protein histidine kinase activity
TDMWS_19960	COG3850	Histidine kinase
TDMWS_19960	COG3437	response regulator, receiver
TDMWS_19960	COG2205	protein histidine kinase activity
TDMWS_19960	COG4999	Histidine kinase
TDMWS_19970	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TDMWS_19990	COG2203	Gaf domain
TDMWS_19990	COG4251	negative regulation of phosphorylation
TDMWS_19990	COG3706	GGDEF domain
TDMWS_19990	COG5001	Diguanylate cyclase
TDMWS_20010	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TDMWS_20030	COG2176	DNA-directed DNA polymerase activity
TDMWS_20050	COG0704	Plays a role in the regulation of phosphate uptake
TDMWS_20060	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TDMWS_20070	COG5002	protein histidine kinase activity
TDMWS_20080	COG0745	RESPONSE REGULATOR receiver
TDMWS_20090	COG5001	Diguanylate cyclase
TDMWS_20110	COG0573	inorganic phosphate transmembrane transporter activity
TDMWS_20300	COG1366	Belongs to the anti-sigma-factor antagonist family
TDMWS_20330	COG2204	response regulator
TDMWS_20360	COG2172	sigma factor antagonist activity
TDMWS_20370	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TDMWS_20440	COG4669	(LipO)protein
TDMWS_20460	COG1317	bacterial-type flagellum organization
TDMWS_20510	COG4790	Type iii secretion
TDMWS_20530	COG4791	protein targeting
TDMWS_20540	COG4792	protein secretion
TDMWS_20570	COG0210	DNA helicase
TDMWS_20580	COG0235	Class ii aldolase
TDMWS_20610	COG1966	Carbon starvation protein
TDMWS_20620	COG0483	inositol monophosphate 1-phosphatase activity
TDMWS_20680	COG0765	amino acid transport
TDMWS_20750	COG2848	UPF0210 protein
TDMWS_20800	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TDMWS_20810	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TDMWS_20820	COG1862	Preprotein translocase
TDMWS_20830	COG4783	chaperone-mediated protein folding
TDMWS_20840	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TDMWS_20840	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TDMWS_20850	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TDMWS_20870	COG0193	aminoacyl-tRNA hydrolase activity
TDMWS_20880	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TDMWS_20890	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TDMWS_20910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TDMWS_20940	COG1077	Cell shape determining protein MreB Mrl
TDMWS_20970	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TDMWS_20980	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TDMWS_21010	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TDMWS_21020	COG1993	acr, cog1993
TDMWS_21030	COG0393	Putative heavy-metal-binding
TDMWS_21060	COG0671	phosphoesterase, PA-phosphatase related
TDMWS_21070	COG0594	ribonuclease P activity
TDMWS_21080	COG0706	membrane insertase activity
TDMWS_21090	COG1847	R3H domain protein
TDMWS_21120	COG0670	Belongs to the BI1 family
TDMWS_21130	COG1663	tetraacyldisaccharide 4'-kinase activity
TDMWS_21140	COG0557	exoribonuclease II activity
TDMWS_21160	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TDMWS_21200	COG3852	Histidine kinase
TDMWS_21230	COG0280	phosphate acetyltransferase
TDMWS_21260	COG0688	phosphatidylethanolamine metabolic process
TDMWS_21290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TDMWS_21290	COG2205	protein histidine kinase activity
TDMWS_21300	COG0784	Response regulator, receiver
TDMWS_21300	COG3437	response regulator, receiver
TDMWS_21330	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TDMWS_21340	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TDMWS_21410	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TDMWS_21420	COG0799	negative regulation of ribosome biogenesis
TDMWS_21430	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TDMWS_21460	COG2186	Transcriptional regulator
TDMWS_21490	COG0288	reversible hydration of carbon dioxide
TDMWS_21570	COG3409	Peptidoglycan-binding domain 1 protein
TDMWS_21570	COG3267	Type II secretory pathway component ExeA
TDMWS_21580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TDMWS_21590	COG1459	type II secretion system
TDMWS_21660	COG2201	protein-glutamate methylesterase activity
TDMWS_21680	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TDMWS_21700	COG1192	Involved in chromosome partitioning
TDMWS_21720	COG0745	RESPONSE REGULATOR receiver
TDMWS_21730	COG2198	Histidine kinase
TDMWS_21730	COG0643	Histidine kinase
TDMWS_21730	COG0784	Response regulator, receiver
TDMWS_21790	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TDMWS_21800	COG2081	HI0933 family
TDMWS_21850	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
TDMWS_21860	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TDMWS_21870	COG0138	bifunctional purine biosynthesis protein purh
TDMWS_21890	COG1815	bacterial-type flagellum-dependent cell motility
TDMWS_21910	COG1677	Flagellar hook-basal body complex protein FliE
TDMWS_21930	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TDMWS_21950	COG1157	protein secretion by the type III secretion system