locus-tag	class	description
N186_00010	COG1013	pyruvate-flavodoxin oxidoreductase activity
N186_00020	COG0493	'glutamate synthase
N186_00060	COG0417	DNA replication proofreading
N186_00090	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
N186_00090	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
N186_00095	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
N186_00105	COG1213	nucleotidyl transferase
N186_00105	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N186_00120	COG0235	Class ii aldolase
N186_00185	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N186_00205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N186_00220	COG0301	tRNA thio-modification
N186_00220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N186_00255	COG0494	nUDIX hydrolase
N186_00275	COG4221	oxidoreductase activity
N186_00320	COG1260	myo-inositol-1-phosphate synthase
N186_00325	COG4608	Belongs to the ABC transporter superfamily
N186_00340	COG0601	transmembrane transport
N186_00345	COG4166	transmembrane transport
N186_00440	COG4591	ABC-type transport system involved in lipoprotein release permease component
N186_00445	COG1136	(ABC) transporter
N186_00465	COG1063	alcohol dehydrogenase
N186_00470	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N186_00475	COG1840	ABC-type Fe3 transport system, periplasmic component
N186_00485	COG1177	transmembrane transport
N186_00490	COG3842	ATPase activity
N186_00495	COG0584	glycerophosphoryl diester phosphodiesterase
N186_00500	COG2094	Belongs to the DNA glycosylase MPG family
N186_00510	COG1067	ATP-dependent peptidase activity
N186_00510	COG0470	DNA polymerase III
N186_00525	COG4150	thiosulfate binding
N186_00545	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
N186_00590	COG0425	Belongs to the sulfur carrier protein TusA family
N186_00605	COG3842	ATPase activity
N186_00640	COG0009	L-threonylcarbamoyladenylate synthase
N186_00655	COG0477	Major facilitator Superfamily
N186_00685	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
N186_00695	COG2217	Heavy metal translocating P-type atpase
N186_00760	COG2033	superoxide reductase activity
N186_00780	COG0017	Asparaginyl-tRNA synthetase
N186_00795	COG1528	Iron-storage protein
N186_00805	COG4948	Mandelate Racemase Muconate Lactonizing
N186_00815	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
N186_00835	COG1363	Peptidase, m42
N186_00840	COG1592	Rubrerythrin
N186_00845	COG1522	sequence-specific DNA binding
N186_00875	COG2814	Major facilitator Superfamily
N186_00880	COG1122	ATPase activity
N186_00885	COG1122	ATPase activity
N186_00890	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
N186_00905	COG0563	adenylate kinase activity
N186_00940	COG3613	nucleoside 2-deoxyribosyltransferase
N186_00945	COG1522	sequence-specific DNA binding
N186_00990	COG0436	Aminotransferase
N186_01065	COG0312	modulator of DNA gyrase
N186_01070	COG0312	modulator of DNA gyrase
N186_01125	COG0531	amino acid
N186_01220	COG0402	S-adenosylhomocysteine deaminase activity
N186_01225	COG0813	purine-nucleoside phosphorylase activity
N186_01235	COG0813	purine-nucleoside phosphorylase activity
N186_01245	COG4720	Psort location CytoplasmicMembrane, score
N186_01260	COG1122	ATPase activity
N186_01295	COG2084	Dehydrogenase
N186_01340	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
N186_01385	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
N186_01390	COG2414	aldehyde ferredoxin oxidoreductase
N186_01445	COG3433	isochorismatase activity
N186_01445	COG1535	isochorismatase
N186_01450	COG4974	Belongs to the 'phage' integrase family
N186_01470	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
N186_01480	COG0148	phosphopyruvate hydratase activity
N186_01485	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
N186_01510	COG0084	hydrolase, TatD family'
N186_01515	COG0439	Biotin carboxylase
N186_01520	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
N186_01525	COG0803	Belongs to the bacterial solute-binding protein 9 family
N186_01550	COG0813	purine-nucleoside phosphorylase activity
N186_01575	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
N186_01610	COG3276	selenocysteine insertion sequence binding
N186_01625	COG0717	Belongs to the dCTP deaminase family
N186_01640	COG0446	pyridine nucleotide-disulphide oxidoreductase
N186_01650	COG4608	Belongs to the ABC transporter superfamily
N186_01655	COG0444	Belongs to the ABC transporter superfamily
N186_01670	COG0747	negative chemotaxis
N186_01695	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
N186_01710	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
N186_01735	COG0003	Pfam Anion-transporting ATPase
N186_01750	COG0714	Associated with various cellular activities
N186_01765	COG0563	adenylate kinase activity
N186_01790	COG0549	Belongs to the carbamate kinase family
N186_01805	COG2414	aldehyde ferredoxin oxidoreductase
N186_01815	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
N186_01825	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
N186_01825	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
N186_01835	COG1980	fructose-bisphosphate aldolase activity
N186_01840	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
N186_01890	COG2379	hydroxypyruvate reductase
N186_01910	COG0488	(ABC) transporter
N186_01930	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
N186_01935	COG0430	RNA-3'-phosphate cyclase activity
N186_01940	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N186_01950	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
N186_01960	COG0081	regulation of translation
N186_01965	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
N186_01970	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
N186_01975	COG1252	NADH dehydrogenase
N186_01985	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
N186_01990	COG0089	rRNA binding
N186_02000	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
N186_02095	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
N186_02115	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
N186_02120	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
N186_02130	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
N186_02140	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
N186_02150	COG0006	proline dipeptidase activity
N186_02185	COG0436	Aminotransferase
N186_02195	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
N186_02200	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
N186_02205	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
N186_02220	COG4948	Mandelate Racemase Muconate Lactonizing
N186_02235	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
N186_02235	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
N186_02240	COG2255	four-way junction helicase activity
N186_02245	COG0049	tRNA binding
N186_02270	COG1355	regulation of microtubule-based process
N186_02275	COG0052	Belongs to the universal ribosomal protein uS2 family
N186_02295	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
N186_02300	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
N186_02325	COG1358	cellular component organization or biogenesis
N186_02330	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
N186_02335	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
N186_02340	COG0085	RNA polymerase activity
N186_02365	COG0423	glycine-tRNA ligase activity
N186_02380	COG0864	Transcriptional regulator
N186_02395	COG0459	protein refolding
N186_02410	COG1247	-acetyltransferase
N186_02430	COG0417	DNA replication proofreading
N186_02470	COG1598	PFAM Uncharacterised protein family UPF0150
N186_02525	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N186_02530	COG1047	Peptidyl-prolyl cis-trans
N186_02545	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
N186_02550	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
N186_02565	COG0521	Mo-molybdopterin cofactor biosynthetic process
N186_02585	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N186_02590	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N186_02600	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
N186_02605	COG2234	aminopeptidase activity
N186_02610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N186_02610	COG0301	tRNA thio-modification
N186_02635	COG0525	valine-tRNA ligase activity
N186_02645	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
N186_02660	COG0469	pyruvate kinase activity
N186_02685	COG1328	CTP reductase activity
N186_02690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N186_02690	COG0045	succinate-CoA ligase (ADP-forming) activity
N186_02690	COG1042	CoA-binding domain protein
N186_02695	COG1269	ATP hydrolysis coupled proton transport
N186_02720	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
N186_02740	COG0501	Belongs to the peptidase M48B family
N186_02800	COG0343	queuine tRNA-ribosyltransferase activity
N186_02820	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N186_02865	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
N186_02880	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
N186_02905	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
N186_02935	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
N186_02940	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
N186_02945	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N186_02970	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
N186_03050	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
N186_03065	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
N186_03070	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
N186_03085	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N186_03140	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N186_03145	COG1793	dna ligase
N186_03155	COG3276	selenocysteine insertion sequence binding
N186_03160	COG0552	protein localization to endoplasmic reticulum
N186_03160	COG0457	Tetratricopeptide repeat
N186_03215	COG1144	Oxidoreductase
N186_03220	COG0674	pyruvate-flavodoxin oxidoreductase activity
N186_03225	COG1013	pyruvate-flavodoxin oxidoreductase activity
N186_03230	COG1110	DNA topoisomerase II activity
N186_03235	COG1056	cytidyltransferase-related domain
N186_03235	COG1051	belongs to the nudix hydrolase family
N186_03245	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
N186_03350	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N186_03370	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
N186_03380	COG1522	sequence-specific DNA binding
N186_03390	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
N186_03395	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
N186_03415	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
N186_03460	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
N186_03465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N186_03470	COG1078	dGTPase activity
N186_03475	COG0071	Belongs to the small heat shock protein (HSP20) family
N186_03480	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
N186_03500	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
N186_03535	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
N186_03540	COG0045	succinate-CoA ligase (ADP-forming) activity
N186_03545	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
N186_03550	COG0528	UMP kinase activity
N186_03560	COG2264	protein methyltransferase activity
N186_03575	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
N186_03580	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
N186_03600	COG1192	Involved in chromosome partitioning
N186_03670	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
N186_03700	COG1201	RNA secondary structure unwinding
N186_03760	COG2226	methyltransferase
N186_03790	COG0426	domain, Protein
N186_03790	COG1773	rubredoxin
N186_03795	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
N186_03815	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
N186_03840	COG1358	cellular component organization or biogenesis
N186_03845	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
N186_03845	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N186_03860	COG1185	polyribonucleotide nucleotidyltransferase activity
N186_03870	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
N186_03905	COG0419	ATPase involved in DNA repair
N186_04060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N186_04065	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
N186_04120	COG1122	ATPase activity
N186_04155	COG0674	pyruvate-flavodoxin oxidoreductase activity
N186_04160	COG1013	pyruvate-flavodoxin oxidoreductase activity
N186_04170	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
N186_04225	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
N186_04305	COG0180	Tryptophanyl-tRNA synthetase
N186_04310	COG0574	Belongs to the PEP-utilizing enzyme family
N186_04310	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
N186_04315	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
N186_04330	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
N186_04345	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
N186_04350	COG0411	ABC transporter
N186_04355	COG0410	ABC transporter
N186_04360	COG0559	Belongs to the binding-protein-dependent transport system permease family
N186_04370	COG1042	CoA-binding domain protein
N186_04370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N186_04370	COG0045	succinate-CoA ligase (ADP-forming) activity
N186_04375	COG0432	Pfam Uncharacterised protein family UPF0047
N186_04380	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
N186_04395	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
N186_04410	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
N186_04420	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
N186_04430	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N186_04435	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N186_04440	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
N186_04445	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
N186_04460	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
N186_04460	COG1793	dna ligase
N186_04490	COG0017	Asparaginyl-tRNA synthetase
N186_04510	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
N186_04545	COG1185	polyribonucleotide nucleotidyltransferase activity
N186_04560	COG0051	transcription antitermination factor activity, RNA binding
N186_04585	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
N186_04615	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
N186_04620	COG0124	histidyl-tRNA synthetase
N186_04625	COG2222	sugar isomerase
N186_04655	COG1234	tRNA 3'-trailer cleavage
N186_04690	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
N186_04690	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
N186_04695	COG1515	deoxyribonuclease V activity
N186_04705	COG0024	Methionine aminopeptidase
N186_04720	COG0585	pseudouridine synthase activity
N186_04725	COG1444	tRNA N-acetyltransferase activity
N186_04735	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N186_04800	COG2205	protein histidine kinase activity
N186_04800	COG0784	Response regulator, receiver
N186_04810	COG0175	sulfate reduction
N186_04870	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
N186_04895	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
N186_04915	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
N186_04920	COG1122	ATPase activity
N186_04925	COG1122	ATPase activity
N186_04930	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
N186_04950	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N186_04985	COG1192	Involved in chromosome partitioning
N186_05045	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
N186_05110	COG2078	PFAM AMMECR1 domain protein
N186_05120	COG1793	dna ligase
N186_05140	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
N186_05165	COG0517	IMP dehydrogenase activity
N186_05165	COG0516	GMP reductase activity
N186_05175	COG0518	GMP synthase (glutamine-hydrolyzing) activity
N186_05175	COG0519	Catalyzes the synthesis of GMP from XMP
N186_05190	COG1254	Belongs to the acylphosphatase family
N186_05200	COG0303	'Molybdopterin
N186_05205	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
N186_05220	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N186_05235	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
N186_05245	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
N186_05250	COG2814	Major facilitator Superfamily
N186_05270	COG0310	cobalt ion transport
N186_05285	COG0109	protoheme IX farnesyltransferase activity
N186_05330	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
N186_05335	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
N186_05345	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N186_05360	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
N186_05385	COG0126	phosphoglycerate kinase activity
N186_05410	COG1574	metal-dependent hydrolase with the TIM-barrel fold
N186_05485	COG1573	uracil-dna glycosylase
N186_05520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N186_05545	COG2835	tetraacyldisaccharide 4'-kinase activity
N186_05550	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N186_05585	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
N186_05595	COG0438	transferase activity, transferring glycosyl groups
N186_05600	COG1449	Belongs to the glycosyl hydrolase 57 family
N186_05615	COG0442	prolyl-tRNA aminoacylation
N186_05620	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
N186_05625	COG1234	tRNA 3'-trailer cleavage
N186_05630	COG1082	Xylose isomerase domain protein TIM barrel
N186_05635	COG1063	alcohol dehydrogenase
N186_05640	COG1402	creatininase
N186_05645	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N186_05650	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
N186_05665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N186_05670	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
N186_05705	COG0330	HflC and HflK could
N186_05730	COG1830	Aldolase
N186_05755	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N186_05765	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
N186_05780	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N186_05790	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
N186_05795	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
N186_05800	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
N186_05815	COG0551	DNA topoisomerase type I activity
N186_05815	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N186_05840	COG0149	triose-phosphate isomerase activity
N186_05890	COG2151	metal-sulfur cluster biosynthetic enzyme
N186_05905	COG2255	four-way junction helicase activity
N186_05940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N186_05950	COG0513	Belongs to the DEAD box helicase family
N186_05955	COG2264	protein methyltransferase activity
N186_05960	COG0017	Asparaginyl-tRNA synthetase
N186_05980	COG2814	Major facilitator Superfamily
N186_05990	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
N186_06005	COG0674	pyruvate-flavodoxin oxidoreductase activity
N186_06005	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
N186_06045	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
N186_06060	COG1940	carbohydrate kinase activity
N186_06075	COG0215	cysteine-tRNA ligase activity
N186_06085	COG1126	abc transporter atp-binding protein
N186_06105	COG0489	protein tyrosine kinase activity
N186_06115	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
N186_06120	COG1177	transmembrane transport
N186_06125	COG1176	ABC-type spermidine putrescine transport system, permease component I
N186_06130	COG3842	ATPase activity
N186_06145	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
N186_06180	COG0037	tRNA processing
N186_06220	COG1201	RNA secondary structure unwinding
N186_06315	COG0656	L-ascorbic acid biosynthetic process
N186_06335	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
N186_06340	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
N186_06365	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
N186_06415	COG0673	inositol 2-dehydrogenase activity
N186_06420	COG1201	RNA secondary structure unwinding
N186_06470	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
N186_06475	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N186_06540	COG0456	acetyltransferase
N186_06550	COG3260	NADH ubiquinone oxidoreductase 20
N186_06555	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
N186_06555	COG3261	NADH dehydrogenase
N186_06565	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
N186_06580	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
N186_06585	COG0651	ATP synthesis coupled electron transport
N186_06595	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N186_06600	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N186_06605	COG0649	NAD binding
N186_06610	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
N186_06625	COG0713	ATP synthesis coupled electron transport
N186_06630	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N186_06635	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
N186_06640	COG1007	ATP synthesis coupled electron transport
N186_06645	COG0174	glutamine synthetase
N186_06650	COG0693	protein deglycase activity
N186_06655	COG4821	SIS domain
N186_06660	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N186_06675	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
N186_06695	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
N186_06705	COG3716	PTS system mannose fructose sorbose family IID component
N186_06710	COG0561	phosphatase activity
N186_06715	COG3037	sugar-specific permease SgaT UlaA
N186_06725	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N186_06730	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N186_06745	COG1122	ATPase activity
N186_06760	COG2723	6-phospho-beta-galactosidase activity
N186_06770	COG1085	galactose-1-phosphate uridylyltransferase
N186_06800	COG0437	4 iron, 4 sulfur cluster binding
N186_06840	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
N186_06865	COG0395	ABC-type sugar transport system, permease component
N186_06870	COG3842	ATPase activity
N186_06880	COG2431	L-lysine efflux transmembrane transporter activity
N186_06910	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N186_06915	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
N186_06920	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
N186_06930	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N186_06935	COG1070	Carbohydrate kinase
N186_06955	COG1175	transmembrane transport
N186_06960	COG0395	ABC-type sugar transport system, permease component
N186_06965	COG1070	Carbohydrate kinase
N186_06980	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
N186_06985	COG0540	Belongs to the ATCase OTCase family
N186_06990	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
N186_06995	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N186_07000	COG0543	2 iron, 2 sulfur cluster binding
N186_07005	COG0167	dihydroorotate dehydrogenase activity
N186_07010	COG1418	mRNA catabolic process
N186_07015	COG0504	CTP synthase activity
N186_07020	COG3842	ATPase activity
N186_07040	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N186_07055	COG1131	(ABC) transporter
N186_07070	COG2095	MarC family integral membrane protein
N186_07085	COG0543	2 iron, 2 sulfur cluster binding
N186_07090	COG0493	'glutamate synthase
N186_07090	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
N186_07120	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
N186_07130	COG0531	amino acid
N186_07170	COG0396	ATPase activity
N186_07190	COG4214	carbohydrate transport
N186_07210	COG5012	cobalamin binding
N186_07250	COG0501	Belongs to the peptidase M48B family
N186_07275	COG1131	(ABC) transporter
N186_07305	COG0667	Aldo Keto reductase
N186_07310	COG1850	ribulose-bisphosphate carboxylase activity
N186_07320	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N186_07385	COG0864	Transcriptional regulator
N186_07390	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N186_07395	COG0277	FAD linked oxidase domain protein
N186_07410	COG0404	The glycine cleavage system catalyzes the degradation of glycine
N186_07410	COG0446	pyridine nucleotide-disulphide oxidoreductase
N186_07420	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
N186_07455	COG1175	transmembrane transport
N186_07460	COG3833	ABC-type maltose transport systems, permease component
N186_07465	COG3842	ATPase activity
N186_07470	COG1378	Sugar-specific transcriptional regulator TrmB
N186_07480	COG1554	hydrolase, family 65, central catalytic
N186_07495	COG0778	Nitroreductase
N186_07510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N186_07515	COG1830	Aldolase
N186_07520	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
N186_07520	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
N186_07525	COG0805	protein transport
N186_07535	COG0805	protein transport
N186_07540	COG0454	-acetyltransferase
N186_07550	COG2095	MarC family integral membrane protein
N186_07570	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
N186_07575	COG0747	negative chemotaxis
N186_07580	COG0601	transmembrane transport
N186_07585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N186_07590	COG0444	Belongs to the ABC transporter superfamily
N186_07595	COG4608	Belongs to the ABC transporter superfamily
N186_07610	COG0243	molybdopterin cofactor binding
N186_07630	COG0471	metal ion transport
N186_07635	COG0409	Hydrogenase expression formation protein
N186_07645	COG0309	Hydrogenase expression formation protein (HypE)
N186_07670	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N186_07680	COG1342	Belongs to the UPF0251 family
N186_07720	COG2211	Major facilitator Superfamily
N186_07735	COG0586	Pfam SNARE associated Golgi protein
N186_07750	COG0668	transmembrane transport
N186_07785	COG0395	ABC-type sugar transport system, permease component
N186_07830	COG1598	PFAM Uncharacterised protein family UPF0150
N186_07840	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
N186_07865	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
N186_07940	COG1088	dTDP-glucose 4,6-dehydratase activity
N186_07945	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N186_08000	COG1215	transferase activity, transferring glycosyl groups
N186_08005	COG0438	transferase activity, transferring glycosyl groups
N186_08020	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
N186_08025	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
N186_08090	COG1598	PFAM Uncharacterised protein family UPF0150
N186_08120	COG1373	ATPase (AAA superfamily
N186_08195	COG1216	Glycosyl transferase, family 2
N186_08195	COG1442	glycosyl transferase family 8
N186_08215	COG0489	protein tyrosine kinase activity
N186_08255	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
N186_08290	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
N186_08335	COG0395	ABC-type sugar transport system, permease component
N186_08380	COG0714	Associated with various cellular activities
N186_08425	COG5012	cobalamin binding
N186_08445	COG0243	molybdopterin cofactor binding
N186_08475	COG2267	carboxylic ester hydrolase activity
N186_08520	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
N186_08540	COG1136	(ABC) transporter
N186_08545	COG0577	efflux transmembrane transporter activity
N186_08545	COG1136	(ABC) transporter
N186_08570	COG1131	(ABC) transporter
N186_08795	COG0438	transferase activity, transferring glycosyl groups
N186_08800	COG1378	Sugar-specific transcriptional regulator TrmB
N186_08805	COG1131	(ABC) transporter
N186_08810	COG0842	Transport permease protein
N186_08835	COG1063	alcohol dehydrogenase
N186_08845	COG0531	amino acid
N186_08855	COG1486	melibiose metabolic process
N186_08905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N186_08925	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
N186_08945	COG0534	Mate efflux family protein
N186_08965	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
N186_08975	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
N186_08995	COG4690	dipeptidase activity
N186_09035	COG2814	Major facilitator Superfamily
N186_09040	COG0402	S-adenosylhomocysteine deaminase activity
N186_09045	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
N186_09060	COG1122	ATPase activity
N186_09065	COG1122	ATPase activity
N186_09070	COG0436	Aminotransferase
N186_09130	COG1028	Short-chain dehydrogenase reductase Sdr
N186_09220	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
N186_09275	COG0471	metal ion transport
N186_09310	COG1872	DUF167
N186_09315	COG4608	Belongs to the ABC transporter superfamily
N186_09320	COG0444	Belongs to the ABC transporter superfamily
N186_09330	COG0601	transmembrane transport
N186_09360	COG0698	ribose 5-phosphate isomerase
N186_09365	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N186_09425	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
N186_09455	COG1575	Belongs to the MenA family. Type 1 subfamily
N186_09460	COG0535	radical SAM domain protein
N186_09470	COG0456	acetyltransferase
N186_09470	COG1214	PFAM Peptidase M22, glycoprotease
N186_09475	COG1058	Belongs to the CinA family
N186_09475	COG1546	Belongs to the CinA family
N186_09540	COG0450	alkyl hydroperoxide reductase
N186_09580	COG0419	ATPase involved in DNA repair
N186_09605	COG0730	response to heat
N186_09615	COG0411	ABC transporter
N186_09635	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N186_09645	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N186_09660	COG0410	ABC transporter
N186_09665	COG0411	ABC transporter
N186_09680	COG0318	PFAM AMP-dependent synthetase and ligase
N186_09690	COG1028	Short-chain dehydrogenase reductase Sdr
N186_09695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N186_09710	COG1042	CoA-binding domain protein
N186_09710	COG0045	succinate-CoA ligase (ADP-forming) activity
N186_09710	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N186_09715	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N186_09715	COG0045	succinate-CoA ligase (ADP-forming) activity
N186_09715	COG1042	CoA-binding domain protein
N186_09720	COG3285	dna ligase
N186_09720	COG1793	dna ligase