locus-tag	class	description
N186_00010	ENOG4105DQU	oxidoreductase, subunit beta
N186_00020	ENOG4105BZ8	glutamate synthase
N186_00060	ENOG4105CQ2	DNA polymerase
N186_00090	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
N186_00095	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
N186_00105	ENOG4108Y5D	Inherit from COG: cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
N186_00185	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
N186_00205	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
N186_00220	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
N186_00235	ENOG4107QK4	glycoside hydrolase, family 3 domain protein
N186_00255	ENOG4108YZ4	nudix hydrolase
N186_00275	ENOG4105EMU	Dehydrogenase
N186_00320	ENOG4105CZA	synthase
N186_00325	ENOG4108JQ7	(ABC) transporter
N186_00340	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
N186_00440	ENOG4105D60	lipoprotein releasing system transmembrane protein
N186_00445	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
N186_00465	ENOG4105CPQ	Dehydrogenase
N186_00470	ENOG4108HMR	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
N186_00485	ENOG4105D38	putrescine abc transporter
N186_00490	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
N186_00495	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
N186_00500	ENOG4108VX5	3-methyladenine DNA glycosylase
N186_00510	ENOG4108IUQ	atp-dependent protease
N186_00525	ENOG4108J2H	Sulfate ABC transporter periplasmic sulfate-binding protein
N186_00530	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
N186_00545	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
N186_00590	ENOG4107XUC	SirA family
N186_00605	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
N186_00640	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
N186_00655	ENOG41079KZ	Major Facilitator Superfamily
N186_00665	ENOG4105PW4	Sugar fermentation stimulation protein homolog
N186_00685	ENOG4105D06	uba thif-type nad fad binding protein
N186_00760	ENOG4108YZ8	Superoxide reductase
N186_00780	ENOG4105C5S	asparaginyl-tRNA synthetase
N186_00795	ENOG41090A1	ferritin
N186_00805	ENOG4105DTQ	mandelate racemase muconate lactonizing
N186_00835	ENOG4105CN9	Peptidase m42 family protein
N186_00840	ENOG4108RAC	Rubrerythrin
N186_00845	ENOG4108RYR	transcriptional regulator AsnC family
N186_00875	ENOG4105C6X	Major Facilitator
N186_00880	ENOG4108JJB	ABC transporter
N186_00885	ENOG4108JJB	ABC transporter
N186_00890	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
N186_00905	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
N186_00940	ENOG41066RC	nucleoside 2-deoxyribosyltransferase
N186_00945	ENOG4105EW9	transcriptional regulator AsnC family
N186_00990	ENOG4105CHM	Aminotransferase
N186_01050	ENOG4108JU3	Alkyl hydroperoxide reductase
N186_01065	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
N186_01070	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
N186_01125	ENOG4105CUB	amino acid
N186_01220	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
N186_01225	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
N186_01235	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
N186_01245	ENOG4108V7D	UPF0397 protein
N186_01260	ENOG4108JJB	ABC transporter
N186_01295	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
N186_01320	ENOG4105CHM	Aminotransferase
N186_01340	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
N186_01385	ENOG4105CMW	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)
N186_01390	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
N186_01445	ENOG4105WQI	isochorismatase
N186_01450	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
N186_01470	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
N186_01480	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
N186_01485	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
N186_01510	ENOG4105F8V	Hydrolase, tatD family
N186_01515	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
N186_01520	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
N186_01525	ENOG4107XSR	periplasmic solute binding protein
N186_01530	ENOG4105DIK	(ABC) transporter
N186_01535	ENOG4105CC5	ABC transporter
N186_01575	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
N186_01610	ENOG4105EM7	Selenocysteine-specific translation elongation factor
N186_01625	ENOG4105DHP	deoxycytidine triphosphate deaminase
N186_01640	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
N186_01650	ENOG4108JQ7	(ABC) transporter
N186_01670	ENOG4105DEF	Extracellular solute-binding protein, family 5
N186_01695	ENOG4105E8R	UPF0173 metal-dependent hydrolase
N186_01710	ENOG4105D8K	carboxyl transferase
N186_01735	ENOG4105D0U	Arsenite-activated ATPase (ArsA)
N186_01750	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
N186_01765	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
N186_01790	ENOG4105C5B	carbamate kinase
N186_01805	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
N186_01810	ENOG4105CN9	Peptidase m42 family protein
N186_01815	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
N186_01825	ENOG4105D1H	recombination factor protein RarA
N186_01835	ENOG4107NFR	Fructose-1,6-bisphosphatase
N186_01855	ENOG4105ECY	inositol monophosphatase
N186_01890	ENOG4105D1Z	hydroxypyruvate reductase
N186_01910	ENOG4105C5H	ABC transporter
N186_01930	ENOG4107V4F	S-adenosyl-l-methionine hydroxide adenosyltransferase
N186_01935	ENOG4105CKX	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP
N186_01940	ENOG4108VTU	Cdp-alcohol phosphatidyltransferase
N186_01950	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
N186_01960	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
N186_01965	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
N186_01970	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
N186_01985	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
N186_01990	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
N186_02000	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
N186_02095	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
N186_02115	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
N186_02120	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
N186_02125	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
N186_02130	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
N186_02140	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
N186_02150	ENOG4105DC7	peptidase M24
N186_02185	ENOG4105CHM	Aminotransferase
N186_02195	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
N186_02200	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
N186_02205	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
N186_02220	ENOG4105DTQ	mandelate racemase muconate lactonizing
N186_02235	ENOG4105D1H	recombination factor protein RarA
N186_02240	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
N186_02245	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
N186_02265	ENOG4106UJV	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
N186_02270	ENOG41074MP	UPF0103 Mediator of ErbB2-driven cell motility-containing protein
N186_02275	ENOG4105CE9	30S ribosomal protein S2
N186_02295	ENOG4108UJD	30S ribosomal protein S9
N186_02300	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
N186_02325	ENOG4105XPM	ribosomal protein
N186_02330	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
N186_02335	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
N186_02340	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
N186_02365	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
N186_02380	ENOG4105MRR	Transcriptional regulator (By similarity)
N186_02395	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
N186_02410	ENOG4105WCN	acetyltransferase
N186_02430	ENOG4105CQ2	DNA polymerase
N186_02470	ENOG41071TK	Uncharacterised protein family (UPF0150)
N186_02525	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
N186_02530	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
N186_02540	ENOG4105EM7	Selenocysteine-specific translation elongation factor
N186_02545	ENOG4105KPK	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
N186_02550	ENOG4105CY0	Metallo-Beta-Lactamase
N186_02565	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
N186_02585	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
N186_02590	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
N186_02605	ENOG4105IIU	Aminopeptidase
N186_02610	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
N186_02635	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
N186_02685	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
N186_02690	ENOG4105CD5	CoA-binding domain protein
N186_02695	ENOG4107WUB	V-type ATPase 116 kDa subunit
N186_02720	ENOG4108JIQ	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity)
N186_02740	ENOG4105D0M	Protease HtpX homolog
N186_02800	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
N186_02820	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
N186_02865	ENOG4105M7V	2'-5' rna ligase
N186_02880	ENOG4108VA3	3-hexulose-6-phosphate synthase
N186_02905	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
N186_02930	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
N186_02935	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
N186_02940	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
N186_02945	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
N186_02970	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
N186_03050	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
N186_03065	ENOG4105DBV	ornithine carbamoyltransferase
N186_03070	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
N186_03085	ENOG4105ESV	Glycosyl transferase, family 4
N186_03140	ENOG4105C2M	dna polymerase I
N186_03145	ENOG4107QIM	DNA ligase
N186_03155	ENOG4105EM7	Selenocysteine-specific translation elongation factor
N186_03160	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
N186_03205	ENOG4105DGU	Histone deacetylase
N186_03215	ENOG4105WGB	oxidoreductase, delta subunit
N186_03220	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
N186_03225	ENOG4105DDK	oxidoreductase, beta subunit
N186_03230	ENOG4106K5Q	Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity)
N186_03245	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
N186_03265	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
N186_03350	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
N186_03370	ENOG41080HJ	6-phospho 3-hexuloisomerase
N186_03380	ENOG4108VVK	transcriptional Regulator, AsnC
N186_03390	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
N186_03395	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
N186_03400	ENOG4107FF9	50s ribosomal protein l29
N186_03415	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
N186_03460	ENOG4105EHU	Circadian clock protein KaiC
N186_03465	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
N186_03470	ENOG4105DCI	Phosphohydrolase
N186_03475	ENOG4105VN1	Heat shock protein
N186_03480	ENOG4105CY0	Metallo-Beta-Lactamase
N186_03500	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
N186_03535	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
N186_03540	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
N186_03545	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
N186_03550	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
N186_03560	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
N186_03565	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
N186_03575	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
N186_03580	ENOG4105EHU	Circadian clock protein KaiC
N186_03600	ENOG4107QJE	Chromosome Partitioning Protein
N186_03670	ENOG4105CB5	ATP-dependent DNA helicase recG
N186_03700	ENOG4107QRT	dEAD DEAH box helicase
N186_03720	ENOG4105DVF	Cytosine-specific methyltransferase
N186_03760	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
N186_03770	ENOG4105CYW	agmatinase
N186_03790	ENOG4105CNW	domain protein
N186_03795	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
N186_03815	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
N186_03840	ENOG4105XPM	ribosomal protein
N186_03845	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
N186_03860	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
N186_03870	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
N186_03905	ENOG4105EYH	Exonuclease
N186_04060	ENOG4105EHG	Permease protein
N186_04065	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
N186_04120	ENOG4108JJB	ABC transporter
N186_04140	ENOG4108JPW	Aminotransferase
N186_04155	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
N186_04160	ENOG4105DDK	oxidoreductase, beta subunit
N186_04170	ENOG4106FVC	RNA methyltransferase
N186_04225	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
N186_04300	ENOG4105C8T	Leucyl-tRNA synthetase
N186_04305	ENOG4105C31	Tryptophanyl-tRNA synthetase
N186_04310	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
N186_04315	ENOG4108USZ	hydrogenase
N186_04330	ENOG4105DPX	Hydrogenase, large subunit
N186_04345	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
N186_04350	ENOG4105C0Z	ABC transporter
N186_04355	ENOG4108IV0	ABC, transporter
N186_04360	ENOG4105C32	Amino acid ABC transporter (Permease)
N186_04370	ENOG4105CD5	CoA-binding domain protein
N186_04375	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
N186_04380	ENOG4105CAS	nag kinase
N186_04395	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
N186_04405	ENOG4105KME	endoribonuclease L-psp
N186_04410	ENOG4105C7B	Threonine dehydratase
N186_04420	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
N186_04430	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
N186_04435	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
N186_04440	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
N186_04445	ENOG4107RHB	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity)
N186_04460	ENOG4107T0X	DNA ligase
N186_04490	ENOG4105C5S	asparaginyl-tRNA synthetase
N186_04510	ENOG4108RCS	geranylgeranylglyceryl phosphate synthase
N186_04545	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
N186_04555	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
N186_04560	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
N186_04585	ENOG4108JA2	transcriptioN-repair coupling factor
N186_04615	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
N186_04620	ENOG4105CUT	histidyl-tRNA synthetase
N186_04625	ENOG4107VCH	Bifunctional phosphoglucose phosphomannose isomerase
N186_04655	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
N186_04690	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
N186_04695	ENOG4105Y7X	Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity)
N186_04705	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
N186_04720	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
N186_04725	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
N186_04735	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
N186_04800	ENOG4105BZU	Histidine kinase
N186_04810	ENOG4105C11	sulfate adenylyltransferase), subunit 2
N186_04870	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
N186_04895	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
N186_04915	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
N186_04920	ENOG4108JJB	ABC transporter
N186_04925	ENOG4108JJB	ABC transporter
N186_04930	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
N186_04985	ENOG4108Q9H	CobQ/CobB/MinD/ParA nucleotide binding domain
N186_05045	ENOG4105DZH	s-adenosylmethionine synthetase (EC 2.5.1.6)
N186_05110	ENOG4105NBF	ammecr1 domain protein
N186_05120	ENOG4107TRG	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity)
N186_05140	ENOG4105C22	threonyL-tRNA synthetase
N186_05165	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
N186_05175	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
N186_05190	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
N186_05205	ENOG4107QJG	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
N186_05210	ENOG4105C8U	phosphate abc transporter
N186_05215	ENOG4105E2Z	phosphate ABC transporter (Permease
N186_05220	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
N186_05235	ENOG4105E3H	phosphoglycerate mutase
N186_05245	ENOG4105C4K	Nad synthetase
N186_05270	ENOG4105CFT	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity)
N186_05285	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
N186_05330	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
N186_05335	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
N186_05340	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
N186_05345	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
N186_05360	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
N186_05385	ENOG4105BZA	Phosphoglycerate kinase
N186_05410	ENOG4105EFZ	amidohydrolase
N186_05450	ENOG4105DK7	lysyl-tRNA synthetase
N186_05485	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
N186_05520	ENOG4107QKV	phosphomannomutase
N186_05545	ENOG4105W49	UPF0434 protein
N186_05550	ENOG4105CX6	glutaminyL-tRNA synthetase
N186_05585	ENOG4105EHU	Circadian clock protein KaiC
N186_05595	ENOG4107STW	synthase
N186_05600	ENOG4105C6W	4-alpha-glucanotransferase (EC 2.4.1.25)
N186_05615	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
N186_05620	ENOG4108Z1Z	gCN5-related N-acetyltransferase
N186_05625	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
N186_05630	ENOG4107S8A	protein TIM barrel
N186_05635	ENOG4105CPQ	Dehydrogenase
N186_05640	ENOG4107W9I	Creatinine amidohydrolase
N186_05645	ENOG4105C5I	Dehydrogenase
N186_05650	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
N186_05665	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
N186_05730	ENOG41061GT	Aldolase
N186_05750	ENOG4105D44	asparaginase
N186_05755	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
N186_05765	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
N186_05770	ENOG4105J5G	Transferase hexapeptide repeat containing protein
N186_05775	ENOG4105CMG	Carbohydrate kinase
N186_05780	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
N186_05790	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
N186_05795	ENOG4108JEB	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
N186_05800	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
N186_05815	ENOG4105C9U	ATP-dependent DNA helicase RecQ
N186_05840	ENOG4105CP7	Triose-phosphate isomerase
N186_05890	ENOG4105VG1	fes assembly suf system protein
N186_05905	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
N186_05940	ENOG4105C0H	protease
N186_05950	ENOG4105C1J	atp-dependent rna helicase
N186_05955	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
N186_05960	ENOG4105C5S	asparaginyl-tRNA synthetase
N186_05980	ENOG4105C6X	Major Facilitator
N186_05990	ENOG4105CYV	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity)
N186_06005	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
N186_06045	ENOG4105D82	Glutamate dehydrogenase
N186_06060	ENOG4105DKQ	ROK family
N186_06075	ENOG4105C8N	cysteinyl-tRNA synthetase
N186_06090	ENOG4105E5Q	amino acid AbC transporter
N186_06105	ENOG4105D1F	ATP-binding protein
N186_06115	ENOG4107RUE	extracellular solute-binding protein family 1
N186_06120	ENOG4105D38	putrescine abc transporter
N186_06125	ENOG4105F38	ABC transporter, permease
N186_06130	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
N186_06145	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
N186_06180	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
N186_06220	ENOG4107QRT	dEAD DEAH box helicase
N186_06310	ENOG41082A2	Alpha beta hydrolase
N186_06315	ENOG4105CV8	reductase
N186_06340	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
N186_06365	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
N186_06415	ENOG4105CK5	oxidoreductase
N186_06420	ENOG4107QRT	dEAD DEAH box helicase
N186_06470	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
N186_06475	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
N186_06540	ENOG4108W0I	acetyltransferase
N186_06550	ENOG4105C47	NADH ubiquinone oxidoreductase 20 kda subunit
N186_06555	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
N186_06560	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
N186_06565	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
N186_06580	ENOG4105D65	subunit l
N186_06585	ENOG4108JPZ	Monovalent cation H antiporter subunit D
N186_06595	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
N186_06600	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
N186_06605	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
N186_06610	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
N186_06625	ENOG41080EA	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
N186_06635	ENOG4105D65	subunit l
N186_06640	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
N186_06645	ENOG4105C5F	glutamine synthetase
N186_06650	ENOG4107R7Y	intracellular protease Pfpi family
N186_06655	ENOG4108SU4	UPF0309 protein
N186_06660	ENOG4105KRI	phosphocarrier protein (HPr
N186_06665	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
N186_06670	ENOG4105CE4	GlcNAc 6-P deacetylase
N186_06675	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
N186_06695	ENOG4108XCU	pts system
N186_06705	ENOG4105F3R	pts system mannose fructose sorbose family iid
N186_06715	ENOG4105CZC	PTS system ascorbate-specific transporter subunit IIC
N186_06725	ENOG4108X7Y	Mannitol-specific cryptic phosphotransferase enzyme iia
N186_06730	ENOG4105DFT	pur operon repressor
N186_06745	ENOG4108JJB	ABC transporter
N186_06770	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
N186_06780	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
N186_06795	ENOG41076HS	cation diffusion facilitator family transporter
N186_06800	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
N186_06840	ENOG4107R5Y	anaerobic glycerol-3-phosphate dehydrogenase, subunit A
N186_06845	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
N186_06870	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
N186_06880	ENOG4105DWU	Membrane
N186_06910	ENOG4105MXW	flavin reductase domain protein, FMN-binding
N186_06915	ENOG4105EHU	Circadian clock protein KaiC
N186_06920	ENOG4106YVY	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity)
N186_06930	ENOG4105C5I	Dehydrogenase
N186_06935	ENOG4105CMG	Carbohydrate kinase
N186_06945	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
N186_06955	ENOG4105HS6	binding-protein-dependent transport systems inner membrane Component
N186_06960	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
N186_06965	ENOG4105CMG	Carbohydrate kinase
N186_06980	ENOG41065E1	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
N186_06985	ENOG4105CXT	aspartate transcarbamylase
N186_06990	ENOG4108R9M	Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity)
N186_06995	ENOG4105CD3	dihydroorotase
N186_07000	ENOG4105DF0	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity)
N186_07005	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
N186_07010	ENOG4105EST	Metal Dependent Phosphohydrolase
N186_07015	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
N186_07020	ENOG4108IJ9	(ABC) transporter
N186_07040	ENOG4105CMR	udp-glucose 4-epimerase
N186_07055	ENOG4105CJ1	ABC, transporter
N186_07070	ENOG41076UM	multiple antibiotic resistance (MarC)-related protein
N186_07085	ENOG4105CDJ	oxidoreductase FAD NAD(P)-binding domain protein
N186_07090	ENOG4105BZ8	glutamate synthase
N186_07110	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
N186_07115	ENOG4108MIC	Mg-protoporphyrin IX methyl transferase
N186_07120	ENOG4108KZ5	Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity)
N186_07130	ENOG4105C0X	amino acid
N186_07190	ENOG4108HWW	ABC transporter
N186_07195	ENOG4105C2J	ABC transporter
N186_07210	ENOG4108Q52	Methyltransferase cognate corrinoid protein
N186_07250	ENOG4105D0M	Protease HtpX homolog
N186_07275	ENOG4105CJ1	ABC, transporter
N186_07305	ENOG4107SET	aldo keto reductase
N186_07310	ENOG4105DT1	RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate
N186_07320	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
N186_07330	ENOG4108MDK	Dehydrogenase
N186_07385	ENOG4105MRR	Transcriptional regulator (By similarity)
N186_07390	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
N186_07410	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
N186_07420	ENOG4108UIN	ybak prolyl-trna synthetase associated region
N186_07460	ENOG4105EG2	ABC transporter, permease
N186_07465	ENOG4108IJ9	(ABC) transporter
N186_07470	ENOG4108NGU	Transcriptional regulator
N186_07480	ENOG4105C71	hydrolase family 65, central catalytic
N186_07495	ENOG4108TVJ	Nitroreductase
N186_07510	ENOG4105D7K	pfkb domain protein
N186_07515	ENOG4105EIE	fructose-bisphosphate aldolase
N186_07520	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
N186_07525	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
N186_07535	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
N186_07540	ENOG4108YM7	Gcn5-related n-acetyltransferase
N186_07550	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
N186_07555	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
N186_07575	ENOG4105DEF	Extracellular solute-binding protein, family 5
N186_07580	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
N186_07585	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
N186_07595	ENOG4108JQ7	(ABC) transporter
N186_07610	ENOG4108J2R	molybdopterin oxidoreductase
N186_07630	ENOG4105C8P	)-transporter
N186_07635	ENOG4105CQS	hydrogenase expression formation protein HypD
N186_07670	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
N186_07680	ENOG4105VYW	UPF0251 protein
N186_07735	ENOG4107T5V	SNARE associated Golgi
N186_07750	ENOG4105D64	Mechanosensitive ion channel
N186_07785	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
N186_07840	ENOG4105E8R	UPF0173 metal-dependent hydrolase
N186_07935	ENOG4107V9E	glucose-1-phosphate thymidylyltransferase
N186_07945	ENOG4105CMR	udp-glucose 4-epimerase
N186_07985	ENOG410838F	Glycosyl transferase family 2
N186_08000	ENOG4108SHN	Glycosyl transferase, family 2
N186_08005	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
N186_08020	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
N186_08030	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
N186_08120	ENOG4105E4P	ATPase (AAA
N186_08215	ENOG4105D1F	ATP-binding protein
N186_08255	ENOG4105F4P	)-transporter
N186_08280	ENOG4108JJB	ABC transporter
N186_08290	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
N186_08335	ENOG4105C50	Binding-protein-dependent transport systems, inner membrane component
N186_08375	ENOG4105CIG	ABC transporter
N186_08380	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
N186_08425	ENOG4108Q52	Methyltransferase cognate corrinoid protein
N186_08440	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
N186_08445	ENOG4105DB1	molybdopterin oxidoreductase
N186_08475	ENOG4105E8V	Alpha Beta Hydrolase Fold protein
N186_08520	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
N186_08540	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
N186_08545	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
N186_08570	ENOG4105CJ1	ABC, transporter
N186_08585	ENOG4105C6T	cysteine synthase
N186_08660	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
N186_08795	ENOG4105E2K	Glycosyl transferase (Group 1
N186_08800	ENOG4108NGU	Transcriptional regulator
N186_08805	ENOG4105CJ1	ABC, transporter
N186_08810	ENOG4107QWP	ABC-2 type transporter
N186_08835	ENOG4105CPQ	Dehydrogenase
N186_08845	ENOG4105CUB	amino acid
N186_08855	ENOG4107V4V	glycoside hydrolase family 4
N186_08905	ENOG4105C0H	protease
N186_08925	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
N186_08945	ENOG4107QI1	Mate efflux family protein
N186_08965	ENOG4107WCI	zn-dependent hydrolase of the beta-lactamase fold-like protein
N186_08975	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
N186_08995	ENOG4105DZW	Dipeptidase
N186_09035	ENOG4105CZM	Major Facilitator
N186_09040	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
N186_09045	ENOG4108I5U	Uridine phosphorylase
N186_09060	ENOG4108JJB	ABC transporter
N186_09065	ENOG4108JJB	ABC transporter
N186_09070	ENOG4105CHM	Aminotransferase
N186_09130	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
N186_09220	ENOG4105C0D	helicase
N186_09275	ENOG4107QPK	)-transporter
N186_09300	ENOG4106JUT	Streptomycin 3''-adenylyltransferase
N186_09310	ENOG4105VZ9	UPF0235 protein
N186_09315	ENOG4108JQ7	(ABC) transporter
N186_09320	ENOG4105C3U	ABC transporter
N186_09325	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
N186_09330	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
N186_09360	ENOG4108YZG	isomerase
N186_09365	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
N186_09400	ENOG4108JQ9	ABC transporter
N186_09405	ENOG4105UIB	(ABC) transporter
N186_09425	ENOG4108I5U	Uridine phosphorylase
N186_09455	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
N186_09460	ENOG4105EZY	Pyrroloquinoline quinone biosynthesis protein E
N186_09475	ENOG4105CEV	competence damage-inducible protein
N186_09540	ENOG4105D3R	alkyl hydroperoxide reductase
N186_09580	ENOG4105EYH	Exonuclease
N186_09610	ENOG4108IV0	ABC, transporter
N186_09615	ENOG4105C0Z	ABC transporter
N186_09635	ENOG4105C5I	Dehydrogenase
N186_09645	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
N186_09660	ENOG4108IV0	ABC, transporter
N186_09665	ENOG4105C0Z	ABC transporter
N186_09670	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
N186_09680	ENOG4105CEY	Amp-dependent synthetase and ligase
N186_09690	ENOG4105CHR	reductase
N186_09695	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
N186_09710	ENOG4105CD5	CoA-binding domain protein
N186_09715	ENOG4105CD5	CoA-binding domain protein
N186_09720	ENOG4105DQE	DNA ligase