locus-tag	class	description
Tpen_0002	ENOG4105CN9	Peptidase m42 family protein
Tpen_0004	ENOG4105C6X	Major Facilitator
Tpen_0005	ENOG4108JJB	ABC transporter
Tpen_0006	ENOG4108JJB	ABC transporter
Tpen_0007	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
Tpen_0010	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
Tpen_0017	ENOG41066RC	nucleoside 2-deoxyribosyltransferase
Tpen_0018	ENOG4105EW9	transcriptional regulator AsnC family
Tpen_0021	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
Tpen_0027	ENOG4105CHM	Aminotransferase
Tpen_0040	ENOG4108JU3	Alkyl hydroperoxide reductase
Tpen_0043	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
Tpen_0044	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
Tpen_0047	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
Tpen_0051	ENOG4108VCT	Sulfite exporter TauE/SafE
Tpen_0053	ENOG4107RY6	amino acid
Tpen_0059	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
Tpen_0060	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
Tpen_0062	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
Tpen_0064	ENOG4108V7D	UPF0397 protein
Tpen_0067	ENOG4108JJB	ABC transporter
Tpen_0068	ENOG4105NSK	ABC superfamily ATP binding cassette transporter membrane protein
Tpen_0076	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
Tpen_0081	ENOG4105CHM	Aminotransferase
Tpen_0085	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
Tpen_0093	ENOG4105CMW	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)
Tpen_0094	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
Tpen_0103	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
Tpen_0106	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
Tpen_0110	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
Tpen_0112	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
Tpen_0116	ENOG4105PFA	Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity)
Tpen_0118	ENOG4105F8V	Hydrolase, tatD family
Tpen_0119	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
Tpen_0120	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
Tpen_0122	ENOG4105DIK	(ABC) transporter
Tpen_0123	ENOG4105CC5	ABC transporter
Tpen_0130	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
Tpen_0140	ENOG4105DHP	deoxycytidine triphosphate deaminase
Tpen_0141	ENOG4105CSM	endonuclease III
Tpen_0142	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
Tpen_0143	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
Tpen_0145	ENOG4108JQ7	(ABC) transporter
Tpen_0148	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
Tpen_0154	ENOG4105E8R	UPF0173 metal-dependent hydrolase
Tpen_0155	ENOG4107QSA	Oxaloacetate decarboxylase
Tpen_0156	ENOG4105D8K	carboxyl transferase
Tpen_0161	ENOG4105D0U	Arsenite-activated ATPase (ArsA)
Tpen_0164	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
Tpen_0167	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
Tpen_0172	ENOG4105C5B	carbamate kinase
Tpen_0176	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
Tpen_0177	ENOG4105CN9	Peptidase m42 family protein
Tpen_0178	ENOG41082CS	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
Tpen_0180	ENOG4105D65	subunit l
Tpen_0181	ENOG4105C47	NADH ubiquinone oxidoreductase 20 kda subunit
Tpen_0183	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Tpen_0184	ENOG4108JPZ	Monovalent cation H antiporter subunit D
Tpen_0185	ENOG4108JPZ	Monovalent cation H antiporter subunit D
Tpen_0187	ENOG4107TDF	Formate hydrogenlyase subunit 4
Tpen_0188	ENOG4108JPZ	Monovalent cation H antiporter subunit D
Tpen_0189	ENOG4105QAX	Iron-sulfur
Tpen_0190	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
Tpen_0191	ENOG4105TMB	Formate nitrite transporter
Tpen_0194	ENOG4105D1H	recombination factor protein RarA
Tpen_0196	ENOG4107NFR	Fructose-1,6-bisphosphatase
Tpen_0200	ENOG4105ECY	inositol monophosphatase
Tpen_0207	ENOG4105D1Z	hydroxypyruvate reductase
Tpen_0212	ENOG4105FDK	ABC transporter
Tpen_0217	ENOG4105CKX	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP
Tpen_0218	ENOG4108VTU	Cdp-alcohol phosphatidyltransferase
Tpen_0221	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
Tpen_0222	ENOG4108VZM	50s ribosomal protein L10
Tpen_0223	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
Tpen_0224	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
Tpen_0225	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
Tpen_0227	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Tpen_0228	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
Tpen_0230	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
Tpen_0234	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
Tpen_0236	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
Tpen_0240	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
Tpen_0242	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Tpen_0244	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
Tpen_0246	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
Tpen_0248	ENOG4105DC7	peptidase M24
Tpen_0255	ENOG4105CHM	Aminotransferase
Tpen_0257	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
Tpen_0258	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
Tpen_0259	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Tpen_0263	ENOG4105DTQ	mandelate racemase muconate lactonizing
Tpen_0266	ENOG4105D1H	recombination factor protein RarA
Tpen_0267	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
Tpen_0273	ENOG41074MP	UPF0103 Mediator of ErbB2-driven cell motility-containing protein
Tpen_0274	ENOG4105CE9	30S ribosomal protein S2
Tpen_0277	ENOG4108UJD	30S ribosomal protein S9
Tpen_0283	ENOG4105XPM	ribosomal protein
Tpen_0284	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Tpen_0285	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Tpen_0286	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Tpen_0288	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
Tpen_0291	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
Tpen_0294	ENOG4105WCN	acetyltransferase
Tpen_0298	ENOG4105CQ2	DNA polymerase
Tpen_0304	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
Tpen_0307	ENOG4105KPK	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
Tpen_0309	ENOG4105CY0	Metallo-Beta-Lactamase
Tpen_0312	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
Tpen_0313	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
Tpen_0316	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
Tpen_0317	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
Tpen_0319	ENOG4105IIU	Aminopeptidase
Tpen_0320	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
Tpen_0335	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
Tpen_0336	ENOG4105CD5	CoA-binding domain protein
Tpen_0337	ENOG4107WUB	V-type ATPase 116 kDa subunit
Tpen_0341	ENOG4108JIP	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity)
Tpen_0342	ENOG4108JIQ	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity)
Tpen_0346	ENOG4105D0M	Protease HtpX homolog
Tpen_0356	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
Tpen_0360	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
Tpen_0369	ENOG4105M7V	2'-5' rna ligase
Tpen_0377	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
Tpen_0379	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
Tpen_0383	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
Tpen_0384	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
Tpen_0385	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
Tpen_0386	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
Tpen_0391	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Tpen_0392	ENOG4105KPK	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
Tpen_0401	ENOG4105CJW	magnesium transporter
Tpen_0404	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
Tpen_0407	ENOG4105DBV	ornithine carbamoyltransferase
Tpen_0408	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
Tpen_0412	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
Tpen_0425	ENOG4105C3M	thioredoxin reductase
Tpen_0426	ENOG4105C2M	dna polymerase I
Tpen_0427	ENOG4107QIM	DNA ligase
Tpen_0429	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
Tpen_0441	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
Tpen_0444	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
Tpen_0447	ENOG4107Y70	Heat shock protein
Tpen_0452	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
Tpen_0456	ENOG4105EHU	Circadian clock protein KaiC
Tpen_0458	ENOG4105DCI	Phosphohydrolase
Tpen_0461	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
Tpen_0476	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
Tpen_0479	ENOG41080HJ	6-phospho 3-hexuloisomerase
Tpen_0483	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
Tpen_0487	ENOG41082SA	50s ribosomal protein l29
Tpen_0488	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
Tpen_0489	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
Tpen_0492	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
Tpen_0493	ENOG4105XPM	ribosomal protein
Tpen_0494	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
Tpen_0499	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
Tpen_0502	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Tpen_0503	ENOG4105CNW	domain protein
Tpen_0504	ENOG4107Y70	Heat shock protein
Tpen_0505	ENOG4108ZJT	translation initiation factor, Sui1
Tpen_0509	ENOG4105CYW	agmatinase
Tpen_0514	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
Tpen_0515	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
Tpen_0516	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
Tpen_0517	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
Tpen_0518	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
Tpen_0520	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
Tpen_0523	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
Tpen_0527	ENOG4105EYH	Exonuclease
Tpen_0539	ENOG4108JPW	Aminotransferase
Tpen_0542	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
Tpen_0543	ENOG4105DDK	oxidoreductase, beta subunit
Tpen_0545	ENOG4106FVC	RNA methyltransferase
Tpen_0546	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
Tpen_0563	ENOG4105EM7	Selenocysteine-specific translation elongation factor
Tpen_0564	ENOG4105C75	arginyL-tRNA synthetase
Tpen_0568	ENOG4105C8T	Leucyl-tRNA synthetase
Tpen_0572	ENOG4105WGB	oxidoreductase, delta subunit
Tpen_0573	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
Tpen_0574	ENOG4105DDK	oxidoreductase, beta subunit
Tpen_0575	ENOG4106K5Q	Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity)
Tpen_0579	ENOG4108VVK	transcriptional Regulator, AsnC
Tpen_0580	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
Tpen_0582	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
Tpen_0587	ENOG4105C31	Tryptophanyl-tRNA synthetase
Tpen_0588	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
Tpen_0592	ENOG4105DPX	Hydrogenase, large subunit
Tpen_0595	ENOG4105WMM	Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity)
Tpen_0596	ENOG4105D1F	ATP-binding protein
Tpen_0598	ENOG4105C0Z	ABC transporter
Tpen_0599	ENOG4108IUZ	ABC transporter
Tpen_0602	ENOG4105CD5	CoA-binding domain protein
Tpen_0608	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
Tpen_0610	ENOG4105KME	endoribonuclease L-psp
Tpen_0611	ENOG4105C7B	Threonine dehydratase
Tpen_0613	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
Tpen_0615	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
Tpen_0616	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
Tpen_0617	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
Tpen_0618	ENOG4107RHB	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity)
Tpen_0620	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
Tpen_0621	ENOG4107T0X	DNA ligase
Tpen_0626	ENOG4105CAT	Cytidine monophosphate kinase
Tpen_0628	ENOG4105C5S	asparaginyl-tRNA synthetase
Tpen_0633	ENOG4108RCS	geranylgeranylglyceryl phosphate synthase
Tpen_0642	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
Tpen_0648	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
Tpen_0652	ENOG4105CB5	ATP-dependent DNA helicase recG
Tpen_0658	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
Tpen_0659	ENOG4105CUT	histidyl-tRNA synthetase
Tpen_0660	ENOG41086CI	Bifunctional phosphoglucose phosphomannose isomerase
Tpen_0665	ENOG4105C11	sulfate adenylyltransferase), subunit 2
Tpen_0679	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
Tpen_0680	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
Tpen_0682	ENOG4105Y7X	Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity)
Tpen_0685	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
Tpen_0686	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
Tpen_0688	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
Tpen_0703	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
Tpen_0708	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
Tpen_0712	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
Tpen_0713	ENOG4108JJB	ABC transporter
Tpen_0714	ENOG4105BZ1	(ABC) transporter
Tpen_0715	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Tpen_0717	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
Tpen_0737	ENOG4105DZH	s-adenosylmethionine synthetase (EC 2.5.1.6)
Tpen_0741	ENOG4107SWE	Methyltransferase
Tpen_0748	ENOG4105NBF	ammecr1 domain protein
Tpen_0750	ENOG4107TRG	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity)
Tpen_0752	ENOG4108RVA	ribokinase
Tpen_0754	ENOG4105C22	threonyL-tRNA synthetase
Tpen_0762	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
Tpen_0764	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
Tpen_0765	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
Tpen_0773	ENOG4105BZA	Phosphoglycerate kinase
Tpen_0778	ENOG4105EFZ	amidohydrolase
Tpen_0791	ENOG4105C6W	4-alpha-glucanotransferase (EC 2.4.1.25)
Tpen_0792	ENOG4107STW	synthase
Tpen_0794	ENOG4105EHU	Circadian clock protein KaiC
Tpen_0798	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
Tpen_0810	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
Tpen_0815	ENOG4105W49	UPF0434 protein
Tpen_0816	ENOG4105CX6	glutaminyL-tRNA synthetase
Tpen_0817	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
Tpen_0818	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
Tpen_0819	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
Tpen_0820	ENOG4107S8A	protein TIM barrel
Tpen_0821	ENOG4105CPQ	Dehydrogenase
Tpen_0822	ENOG4107W9I	Creatinine amidohydrolase
Tpen_0823	ENOG4105C5I	Dehydrogenase
Tpen_0824	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
Tpen_0826	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
Tpen_0837	ENOG41061GT	Aldolase
Tpen_0841	ENOG4105D44	asparaginase
Tpen_0843	ENOG4105D82	Glutamate dehydrogenase
Tpen_0847	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
Tpen_0848	ENOG4105C5S	asparaginyl-tRNA synthetase
Tpen_0850	ENOG4105CE1	Ferrous iron transport protein b
Tpen_0854	ENOG4105CYV	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity)
Tpen_0857	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
Tpen_0861	ENOG4105C1J	atp-dependent rna helicase
Tpen_0862	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
Tpen_0875	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
Tpen_0876	ENOG4105VG1	fes assembly suf system protein
Tpen_0883	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
Tpen_0885	ENOG4105C9U	ATP-dependent DNA helicase RecQ
Tpen_0890	ENOG4108JEB	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
Tpen_0893	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
Tpen_0894	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
Tpen_0895	ENOG4105J5G	Transferase hexapeptide repeat containing protein
Tpen_0896	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
Tpen_0898	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
Tpen_0902	ENOG4105C8N	cysteinyl-tRNA synthetase
Tpen_0904	ENOG4105CDA	abc transporter atp-binding protein
Tpen_0905	ENOG4105E5Q	amino acid AbC transporter
Tpen_0908	ENOG4105D1F	ATP-binding protein
Tpen_0910	ENOG4107RUE	extracellular solute-binding protein family 1
Tpen_0911	ENOG4105D38	putrescine abc transporter
Tpen_0912	ENOG4105F38	ABC transporter, permease
Tpen_0913	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
Tpen_0916	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
Tpen_0923	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
Tpen_0930	ENOG4107QRT	dEAD DEAH box helicase
Tpen_0944	ENOG4105CV8	reductase
Tpen_0945	ENOG4108V1U	phospholipid-binding protein
Tpen_0949	ENOG4105C9B	Cysteine desulfurase
Tpen_0950	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
Tpen_0973	ENOG4105KST	dependent repressor
Tpen_0976	ENOG4105CE1	Ferrous iron transport protein b
Tpen_0985	ENOG4105C0D	helicase
Tpen_0987	ENOG4107QJE	Chromosome Partitioning Protein
Tpen_0990	ENOG41082CH	UPF0145 protein
Tpen_0997	ENOG4105D1F	ATP-binding protein
Tpen_1004	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
Tpen_1009	ENOG4105K59	histidine triad (HIT) protein
Tpen_1013	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
Tpen_1014	ENOG4107QRT	dEAD DEAH box helicase
Tpen_1023	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
Tpen_1026	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
Tpen_1030	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
Tpen_1040	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
Tpen_1041	ENOG4105E09	nadh pyrophosphatase
Tpen_1044	ENOG4105C4K	Nad synthetase
Tpen_1046	ENOG4105E3H	phosphoglycerate mutase
Tpen_1052	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
Tpen_1055	ENOG4107FKK	extracellular solute-binding protein family 1
Tpen_1057	ENOG4105EG2	ABC transporter, permease
Tpen_1058	ENOG4107QMV	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
Tpen_1059	ENOG4105C8U	phosphate abc transporter
Tpen_1060	ENOG4105E2Z	phosphate ABC transporter (Permease
Tpen_1064	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
Tpen_1070	ENOG4105C47	NADH ubiquinone oxidoreductase 20 kda subunit
Tpen_1071	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Tpen_1073	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
Tpen_1077	ENOG4108JPZ	Monovalent cation H antiporter subunit D
Tpen_1079	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Tpen_1080	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Tpen_1081	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Tpen_1082	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
Tpen_1085	ENOG41080EA	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Tpen_1086	ENOG4105C8S	subunit m
Tpen_1087	ENOG4105D65	subunit l
Tpen_1088	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Tpen_1089	ENOG4105C5F	glutamine synthetase
Tpen_1090	ENOG4108SU4	UPF0309 protein
Tpen_1091	ENOG4105KRI	phosphocarrier protein (HPr
Tpen_1092	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
Tpen_1093	ENOG4105CE4	GlcNAc 6-P deacetylase
Tpen_1094	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
Tpen_1098	ENOG4108XCU	pts system
Tpen_1100	ENOG4105F3R	pts system mannose fructose sorbose family iid
Tpen_1102	ENOG4105DFT	pur operon repressor
Tpen_1105	ENOG4108JJB	ABC transporter
Tpen_1110	ENOG4105CS2	ec 3.2.1.21
Tpen_1112	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
Tpen_1114	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
Tpen_1121	ENOG4108J2R	molybdopterin oxidoreductase
Tpen_1122	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
Tpen_1127	ENOG4107R5Y	anaerobic glycerol-3-phosphate dehydrogenase, subunit A
Tpen_1128	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
Tpen_1129	ENOG4105K63	Thioredoxin
Tpen_1134	ENOG4105DWU	Membrane
Tpen_1136	ENOG4105CJ1	ABC, transporter
Tpen_1140	ENOG4105C5S	asparaginyl-tRNA synthetase
Tpen_1141	ENOG4105MXW	flavin reductase domain protein, FMN-binding
Tpen_1147	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
Tpen_1148	ENOG4108DJF	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
Tpen_1149	ENOG4108IJ9	(ABC) transporter
Tpen_1150	ENOG4105EG2	ABC transporter, permease
Tpen_1155	ENOG4105C71	hydrolase family 65, central catalytic
Tpen_1157	ENOG4105CXT	aspartate transcarbamylase
Tpen_1158	ENOG4108R9M	Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity)
Tpen_1159	ENOG4105CD3	dihydroorotase
Tpen_1160	ENOG4105CDJ	oxidoreductase FAD NAD(P)-binding domain protein
Tpen_1161	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
Tpen_1162	ENOG4105EST	Metal Dependent Phosphohydrolase
Tpen_1163	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
Tpen_1168	ENOG4108KS2	transglutaminase domain protein
Tpen_1169	ENOG4105CMR	udp-glucose 4-epimerase
Tpen_1172	ENOG4105CJ1	ABC, transporter
Tpen_1176	ENOG4105EG2	ABC transporter, permease
Tpen_1179	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
Tpen_1180	ENOG4105EZY	Pyrroloquinoline quinone biosynthesis protein E
Tpen_1185	ENOG41081FY	multiple antibiotic resistance (MarC)-related
Tpen_1193	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
Tpen_1196	ENOG4105CUB	amino acid
Tpen_1199	ENOG4107QZT	geranylgeranyl reductase
Tpen_1205	ENOG4105C3K	feS assembly ATPase SufC
Tpen_1209	ENOG41062B0	ABC transporter, permease
Tpen_1210	ENOG4105C2J	ABC transporter
Tpen_1212	ENOG4108Q52	Methyltransferase cognate corrinoid protein
Tpen_1218	ENOG4105D0M	Protease HtpX homolog
Tpen_1222	ENOG4105CJ1	ABC, transporter
Tpen_1228	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
Tpen_1231	ENOG4108MDK	Dehydrogenase
Tpen_1233	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
Tpen_1236	ENOG4105MRR	Transcriptional regulator (By similarity)
Tpen_1237	ENOG4108UIN	ybak prolyl-trna synthetase associated region
Tpen_1240	ENOG4107SXA	Phosphorylase
Tpen_1241	ENOG4108YZG	isomerase
Tpen_1246	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
Tpen_1247	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Tpen_1248	ENOG4105C3U	ABC transporter
Tpen_1249	ENOG4108JQ7	(ABC) transporter
Tpen_1250	ENOG4108Y5D	Inherit from COG: cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
Tpen_1256	ENOG4105S9S	Binding-protein-dependent transport systems, inner membrane component
Tpen_1258	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
Tpen_1262	ENOG4105E4P	ATPase (AAA
Tpen_1265	ENOG4108MYP	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
Tpen_1268	ENOG4107R56	PP-loop domain protein
Tpen_1271	ENOG4107YM4	Beta-lactamase domain-containing protein
Tpen_1273	ENOG4105CJ1	ABC, transporter
Tpen_1313	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
Tpen_1314	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
Tpen_1321	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
Tpen_1344	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
Tpen_1350	ENOG4107RT5	aminobenzoyl-glutamate utilization protein B
Tpen_1352	ENOG4107QRT	dEAD DEAH box helicase
Tpen_1373	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
Tpen_1375	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
Tpen_1376	ENOG4105CEV	competence damage-inducible protein
Tpen_1382	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
Tpen_1387	ENOG4105E5G	Alpha beta hydrolase fold
Tpen_1388	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
Tpen_1395	ENOG4105C6T	cysteine synthase
Tpen_1400	ENOG4105CJ1	ABC, transporter
Tpen_1403	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Tpen_1404	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Tpen_1409	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
Tpen_1417	ENOG4105CHM	Aminotransferase
Tpen_1419	ENOG4105CJ1	ABC, transporter
Tpen_1425	ENOG4105EHG	Permease protein
Tpen_1426	ENOG4105E0A	ABC, transporter
Tpen_1427	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
Tpen_1430	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Tpen_1444	ENOG4105C4K	Nad synthetase
Tpen_1445	ENOG4105C4K	Nad synthetase
Tpen_1451	ENOG4105EG2	ABC transporter, permease
Tpen_1453	ENOG4107FKK	extracellular solute-binding protein family 1
Tpen_1455	ENOG4105DQU	oxidoreductase, subunit beta
Tpen_1457	ENOG4105VCQ	rubredoxin
Tpen_1462	ENOG4105CJ1	ABC, transporter
Tpen_1465	ENOG4105FB2	class II Aldolase
Tpen_1466	ENOG41068KF	Universal stress protein
Tpen_1468	ENOG4108Q52	Methyltransferase cognate corrinoid protein
Tpen_1479	ENOG4105D9K	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
Tpen_1484	ENOG4105D7N	magnesium and cobalt transport protein CorA
Tpen_1485	ENOG4107QKW	extracellular solute-binding protein family 1
Tpen_1488	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
Tpen_1491	ENOG4107ZYJ	bioY protein
Tpen_1493	ENOG4107WCI	zn-dependent hydrolase of the beta-lactamase fold-like protein
Tpen_1494	ENOG4107QK4	glycoside hydrolase, family 3 domain protein
Tpen_1511	ENOG4107V4V	glycoside hydrolase family 4
Tpen_1528	ENOG4105C0H	protease
Tpen_1530	ENOG4105C3K	feS assembly ATPase SufC
Tpen_1532	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
Tpen_1534	ENOG4108V7D	UPF0397 protein
Tpen_1535	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
Tpen_1537	ENOG4108IYI	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
Tpen_1541	ENOG4108JJB	ABC transporter
Tpen_1544	ENOG4108JJB	ABC transporter
Tpen_1545	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
Tpen_1553	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
Tpen_1564	ENOG4107QPK	)-transporter
Tpen_1566	ENOG4105CN5	Metallo-Beta-Lactamase
Tpen_1567	ENOG4105E3H	phosphoglycerate mutase
Tpen_1570	ENOG4105D3R	alkyl hydroperoxide reductase
Tpen_1574	ENOG4105EYH	Exonuclease
Tpen_1575	ENOG4105C5I	Dehydrogenase
Tpen_1578	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
Tpen_1579	ENOG4105C0Z	ABC transporter
Tpen_1580	ENOG4108IV0	ABC, transporter
Tpen_1581	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
Tpen_1588	ENOG4108JP0	extracellular solute-binding protein family 1
Tpen_1589	ENOG4105S9S	Binding-protein-dependent transport systems, inner membrane component
Tpen_1590	ENOG4105EB1	binding-protein-dependent transport systems inner membrane Component
Tpen_1592	ENOG41088YS	Glycosyl transferase (Group 1
Tpen_1605	ENOG4105C6T	cysteine synthase
Tpen_1606	ENOG4108RAC	Rubrerythrin
Tpen_1608	ENOG4108R96	Methyltransferase, YaeB family
Tpen_1611	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
Tpen_1616	ENOG4105CMG	Carbohydrate kinase
Tpen_1617	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
Tpen_1620	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
Tpen_1622	ENOG4105CMG	Carbohydrate kinase
Tpen_1623	ENOG4105C5I	Dehydrogenase
Tpen_1630	ENOG4108K16	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
Tpen_1631	ENOG4108J2R	molybdopterin oxidoreductase
Tpen_1634	ENOG4108JQ7	(ABC) transporter
Tpen_1636	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Tpen_1637	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
Tpen_1638	ENOG4105DEF	Extracellular solute-binding protein, family 5
Tpen_1640	ENOG4105CUB	amino acid
Tpen_1641	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
Tpen_1642	ENOG41081FY	multiple antibiotic resistance (MarC)-related
Tpen_1645	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
Tpen_1647	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
Tpen_1648	ENOG4105EIE	fructose-bisphosphate aldolase
Tpen_1649	ENOG4105D7K	pfkb domain protein
Tpen_1652	ENOG4107Y03	Nitroreductase
Tpen_1653	ENOG4106K7D	Major facilitator family transporter
Tpen_1664	ENOG4105CHM	Aminotransferase
Tpen_1666	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
Tpen_1667	ENOG4105D4F	Synthesizes selenophosphate from selenide and ATP (By similarity)
Tpen_1670	ENOG4105CPC	Aldo Keto reductase
Tpen_1677	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
Tpen_1679	ENOG4105C3U	ABC transporter
Tpen_1680	ENOG4108JQ7	(ABC) transporter
Tpen_1683	ENOG41079KZ	Major Facilitator Superfamily
Tpen_1714	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
Tpen_1715	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
Tpen_1719	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
Tpen_1721	ENOG4107T8Q	Glycosyl transferase (Group 1
Tpen_1723	ENOG4105CPK	Glycosyl transferase (Group 1
Tpen_1739	ENOG4105CFT	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity)
Tpen_1742	ENOG4108JJB	ABC transporter
Tpen_1743	ENOG4107XB0	Lipopolysaccharide 1,2-N-acetylglucosaminetransferase
Tpen_1744	ENOG4107UU3	sucrose-phosphate synthase (EC 2.4.1.14)
Tpen_1746	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
Tpen_1750	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
Tpen_1751	ENOG4105CIG	ABC transporter
Tpen_1760	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Tpen_1762	ENOG4105C1J	atp-dependent rna helicase
Tpen_1763	ENOG4105VYW	UPF0251 protein
Tpen_1766	ENOG4105BZ8	glutamate synthase
Tpen_1772	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
Tpen_1775	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Tpen_1776	ENOG4105D60	lipoprotein releasing system transmembrane protein
Tpen_1778	ENOG4108IUN	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
Tpen_1787	ENOG4108IUQ	atp-dependent protease
Tpen_1791	ENOG4108VX5	3-methyladenine DNA glycosylase
Tpen_1803	ENOG4107XUC	SirA family
Tpen_1806	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
Tpen_1813	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
Tpen_1818	ENOG4105PW4	Sugar fermentation stimulation protein homolog
Tpen_1820	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
Tpen_1821	ENOG4105CHR	reductase
Tpen_1822	ENOG4105D06	uba thif-type nad fad binding protein
Tpen_1829	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
Tpen_1830	ENOG4108YZ8	Superoxide reductase
Tpen_1833	ENOG4105C5S	asparaginyl-tRNA synthetase
Tpen_1837	ENOG4105DTQ	mandelate racemase muconate lactonizing
Tpen_1875	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
Tpen_1891	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)