locus-tag	class	description
Tpen_0002	COG1363	Peptidase, m42
Tpen_0004	COG2814	Major facilitator Superfamily
Tpen_0005	COG1122	ATPase activity
Tpen_0006	COG1122	ATPase activity
Tpen_0007	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Tpen_0010	COG0563	adenylate kinase activity
Tpen_0017	COG3613	nucleoside 2-deoxyribosyltransferase
Tpen_0027	COG0436	Aminotransferase
Tpen_0043	COG0312	modulator of DNA gyrase
Tpen_0044	COG0312	modulator of DNA gyrase
Tpen_0047	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Tpen_0051	COG0730	response to heat
Tpen_0053	COG0531	amino acid
Tpen_0059	COG0402	S-adenosylhomocysteine deaminase activity
Tpen_0060	COG0813	purine-nucleoside phosphorylase activity
Tpen_0062	COG0813	purine-nucleoside phosphorylase activity
Tpen_0064	COG4720	Psort location CytoplasmicMembrane, score
Tpen_0067	COG1122	ATPase activity
Tpen_0068	COG4721	ABC-type cobalt transport system, permease component
Tpen_0076	COG2084	Dehydrogenase
Tpen_0085	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Tpen_0093	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
Tpen_0094	COG2414	aldehyde ferredoxin oxidoreductase
Tpen_0103	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tpen_0103	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tpen_0106	COG4974	Belongs to the 'phage' integrase family
Tpen_0110	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Tpen_0112	COG0148	phosphopyruvate hydratase activity
Tpen_0116	COG0500	methyltransferase
Tpen_0118	COG0084	hydrolase, TatD family'
Tpen_0119	COG0439	Biotin carboxylase
Tpen_0120	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Tpen_0122	COG1121	(ABC) transporter
Tpen_0126	COG0813	purine-nucleoside phosphorylase activity
Tpen_0130	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Tpen_0140	COG0717	Belongs to the dCTP deaminase family
Tpen_0141	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Tpen_0142	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Tpen_0143	COG0446	pyridine nucleotide-disulphide oxidoreductase
Tpen_0145	COG4608	Belongs to the ABC transporter superfamily
Tpen_0146	COG0444	Belongs to the ABC transporter superfamily
Tpen_0148	COG0601	transmembrane transport
Tpen_0150	COG1522	sequence-specific DNA binding
Tpen_0154	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Tpen_0155	COG0511	ligase activity, forming carbon-carbon bonds
Tpen_0155	COG5016	pyruvate
Tpen_0156	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Tpen_0161	COG0003	Pfam Anion-transporting ATPase
Tpen_0164	COG0714	Associated with various cellular activities
Tpen_0167	COG0563	adenylate kinase activity
Tpen_0176	COG2414	aldehyde ferredoxin oxidoreductase
Tpen_0180	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Tpen_0181	COG3260	NADH ubiquinone oxidoreductase 20
Tpen_0182	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tpen_0183	COG3261	NADH dehydrogenase
Tpen_0183	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
Tpen_0184	COG0651	ATP synthesis coupled electron transport
Tpen_0185	COG0651	ATP synthesis coupled electron transport
Tpen_0187	COG0650	Formate hydrogenlyase subunit 4
Tpen_0188	COG0651	ATP synthesis coupled electron transport
Tpen_0189	COG0437	4 iron, 4 sulfur cluster binding
Tpen_0190	COG3383	formate dehydrogenase (NAD+) activity
Tpen_0191	COG2116	formate transmembrane transporter activity
Tpen_0194	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Tpen_0194	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Tpen_0196	COG1980	fructose-bisphosphate aldolase activity
Tpen_0197	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Tpen_0200	COG0483	inositol monophosphate 1-phosphatase activity
Tpen_0207	COG2379	hydroxypyruvate reductase
Tpen_0212	COG1121	(ABC) transporter
Tpen_0217	COG0430	RNA-3'-phosphate cyclase activity
Tpen_0218	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Tpen_0221	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Tpen_0222	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Tpen_0223	COG0081	regulation of translation
Tpen_0224	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Tpen_0226	COG1252	NADH dehydrogenase
Tpen_0227	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Tpen_0228	COG0089	rRNA binding
Tpen_0230	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Tpen_0234	COG0200	Binds to the 23S rRNA
Tpen_0236	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Tpen_0240	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Tpen_0242	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Tpen_0244	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Tpen_0246	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Tpen_0248	COG0006	proline dipeptidase activity
Tpen_0255	COG0436	Aminotransferase
Tpen_0257	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Tpen_0258	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Tpen_0259	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Tpen_0263	COG4948	Mandelate Racemase Muconate Lactonizing
Tpen_0266	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Tpen_0266	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Tpen_0267	COG2255	four-way junction helicase activity
Tpen_0272	COG1304	FMN binding
Tpen_0273	COG1355	regulation of microtubule-based process
Tpen_0274	COG0052	Belongs to the universal ribosomal protein uS2 family
Tpen_0277	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Tpen_0283	COG1358	cellular component organization or biogenesis
Tpen_0284	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Tpen_0285	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Tpen_0286	COG0085	RNA polymerase activity
Tpen_0288	COG0423	glycine-tRNA ligase activity
Tpen_0291	COG0459	protein refolding
Tpen_0294	COG1247	-acetyltransferase
Tpen_0298	COG0417	DNA replication proofreading
Tpen_0304	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Tpen_0307	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Tpen_0309	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Tpen_0312	COG0521	Mo-molybdopterin cofactor biosynthetic process
Tpen_0313	COG0315	cyclic pyranopterin monophosphate synthase activity
Tpen_0316	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Tpen_0317	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Tpen_0318	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Tpen_0319	COG2234	aminopeptidase activity
Tpen_0320	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Tpen_0320	COG0301	tRNA thio-modification
Tpen_0327	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Tpen_0330	COG0469	pyruvate kinase activity
Tpen_0336	COG0045	succinate-CoA ligase (ADP-forming) activity
Tpen_0336	COG1042	CoA-binding domain protein
Tpen_0336	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Tpen_0337	COG1269	ATP hydrolysis coupled proton transport
Tpen_0341	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
Tpen_0342	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
Tpen_0346	COG0501	Belongs to the peptidase M48B family
Tpen_0356	COG0343	queuine tRNA-ribosyltransferase activity
Tpen_0360	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Tpen_0369	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
Tpen_0377	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Tpen_0379	COG2264	protein methyltransferase activity
Tpen_0383	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
Tpen_0385	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Tpen_0386	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Tpen_0391	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Tpen_0392	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Tpen_0401	COG2239	Acts as a magnesium transporter
Tpen_0404	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Tpen_0407	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Tpen_0408	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Tpen_0412	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Tpen_0425	COG0492	ferredoxin-NADP+ reductase activity
Tpen_0425	COG3118	belongs to the thioredoxin family
Tpen_0426	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Tpen_0426	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Tpen_0427	COG1793	dna ligase
Tpen_0429	COG0552	protein localization to endoplasmic reticulum
Tpen_0429	COG0457	Tetratricopeptide repeat
Tpen_0441	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Tpen_0444	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Tpen_0447	COG0071	Belongs to the small heat shock protein (HSP20) family
Tpen_0452	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Tpen_0456	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
Tpen_0458	COG1078	dGTPase activity
Tpen_0461	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Tpen_0476	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Tpen_0479	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Tpen_0483	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Tpen_0487	COG0255	Belongs to the universal ribosomal protein uL29 family
Tpen_0488	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Tpen_0489	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Tpen_0492	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Tpen_0493	COG1358	cellular component organization or biogenesis
Tpen_0494	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Tpen_0494	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Tpen_0499	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Tpen_0502	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Tpen_0503	COG1773	rubredoxin
Tpen_0503	COG0426	domain, Protein
Tpen_0504	COG0071	Belongs to the small heat shock protein (HSP20) family
Tpen_0505	COG0023	Translation Initiation Factor
Tpen_0509	COG0010	Belongs to the arginase family
Tpen_0514	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Tpen_0514	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Tpen_0515	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Tpen_0516	COG0045	succinate-CoA ligase (ADP-forming) activity
Tpen_0517	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Tpen_0518	COG0528	UMP kinase activity
Tpen_0520	COG2264	protein methyltransferase activity
Tpen_0523	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Tpen_0524	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
Tpen_0527	COG0419	ATPase involved in DNA repair
Tpen_0542	COG0674	pyruvate-flavodoxin oxidoreductase activity
Tpen_0543	COG1013	pyruvate-flavodoxin oxidoreductase activity
Tpen_0545	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
Tpen_0546	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Tpen_0564	COG0018	arginyl-trna synthetase
Tpen_0568	COG0495	leucyl-tRNA aminoacylation
Tpen_0570	COG0123	including yeast histone deacetylase and acetoin utilization protein
Tpen_0572	COG1144	Oxidoreductase
Tpen_0573	COG0674	pyruvate-flavodoxin oxidoreductase activity
Tpen_0574	COG1013	pyruvate-flavodoxin oxidoreductase activity
Tpen_0575	COG1110	DNA topoisomerase II activity
Tpen_0576	COG1051	belongs to the nudix hydrolase family
Tpen_0576	COG1056	cytidyltransferase-related domain
Tpen_0579	COG1522	sequence-specific DNA binding
Tpen_0580	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Tpen_0582	COG1185	polyribonucleotide nucleotidyltransferase activity
Tpen_0587	COG0180	Tryptophanyl-tRNA synthetase
Tpen_0588	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Tpen_0588	COG0574	Belongs to the PEP-utilizing enzyme family
Tpen_0592	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
Tpen_0595	COG0375	protein maturation
Tpen_0596	COG0489	protein tyrosine kinase activity
Tpen_0597	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Tpen_0599	COG1137	ATPase activity
Tpen_0602	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Tpen_0602	COG1042	CoA-binding domain protein
Tpen_0602	COG0045	succinate-CoA ligase (ADP-forming) activity
Tpen_0608	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Tpen_0610	COG0251	oxidation-reduction process
Tpen_0611	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Tpen_0613	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Tpen_0615	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tpen_0616	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tpen_0617	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Tpen_0618	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Tpen_0620	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
Tpen_0621	COG1793	dna ligase
Tpen_0621	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Tpen_0626	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Tpen_0628	COG0017	Asparaginyl-tRNA synthetase
Tpen_0633	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
Tpen_0642	COG1185	polyribonucleotide nucleotidyltransferase activity
Tpen_0648	COG0051	transcription antitermination factor activity, RNA binding
Tpen_0652	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Tpen_0659	COG0124	histidyl-tRNA synthetase
Tpen_0660	COG2222	sugar isomerase
Tpen_0665	COG0175	sulfate reduction
Tpen_0679	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Tpen_0680	COG0024	Methionine aminopeptidase
Tpen_0685	COG0585	pseudouridine synthase activity
Tpen_0686	COG1444	tRNA N-acetyltransferase activity
Tpen_0688	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Tpen_0688	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Tpen_0703	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Tpen_0708	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Tpen_0712	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Tpen_0713	COG1122	ATPase activity
Tpen_0714	COG3845	ABC transporter
Tpen_0715	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Tpen_0717	COG0673	inositol 2-dehydrogenase activity
Tpen_0737	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
Tpen_0741	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Tpen_0748	COG2078	PFAM AMMECR1 domain protein
Tpen_0750	COG1793	dna ligase
Tpen_0752	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Tpen_0754	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Tpen_0762	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Tpen_0765	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Tpen_0773	COG0126	phosphoglycerate kinase activity
Tpen_0778	COG1574	metal-dependent hydrolase with the TIM-barrel fold
Tpen_0791	COG1449	Belongs to the glycosyl hydrolase 57 family
Tpen_0792	COG0438	transferase activity, transferring glycosyl groups
Tpen_0794	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
Tpen_0798	COG1573	uracil-dna glycosylase
Tpen_0810	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Tpen_0815	COG2835	tetraacyldisaccharide 4'-kinase activity
Tpen_0816	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Tpen_0817	COG0442	prolyl-tRNA aminoacylation
Tpen_0818	COG0456	acetyltransferase
Tpen_0819	COG1234	tRNA 3'-trailer cleavage
Tpen_0820	COG1082	Xylose isomerase domain protein TIM barrel
Tpen_0821	COG1063	alcohol dehydrogenase
Tpen_0822	COG1402	creatininase
Tpen_0823	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Tpen_0824	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
Tpen_0826	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Tpen_0827	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Tpen_0832	COG0330	HflC and HflK could
Tpen_0837	COG1830	Aldolase
Tpen_0843	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Tpen_0847	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Tpen_0848	COG0017	Asparaginyl-tRNA synthetase
Tpen_0850	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Tpen_0850	COG1918	ferrous iron import across plasma membrane
Tpen_0854	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
Tpen_0857	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Tpen_0857	COG0674	pyruvate-flavodoxin oxidoreductase activity
Tpen_0862	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Tpen_0876	COG2151	metal-sulfur cluster biosynthetic enzyme
Tpen_0883	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Tpen_0890	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
Tpen_0893	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tpen_0894	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Tpen_0896	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Tpen_0898	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Tpen_0901	COG1940	carbohydrate kinase activity
Tpen_0902	COG0215	cysteine-tRNA ligase activity
Tpen_0904	COG1126	abc transporter atp-binding protein
Tpen_0908	COG0489	protein tyrosine kinase activity
Tpen_0910	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Tpen_0911	COG1177	transmembrane transport
Tpen_0912	COG1176	ABC-type spermidine putrescine transport system, permease component I
Tpen_0913	COG3842	ATPase activity
Tpen_0916	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Tpen_0923	COG0037	tRNA processing
Tpen_0930	COG1201	RNA secondary structure unwinding
Tpen_0944	COG0656	L-ascorbic acid biosynthetic process
Tpen_0945	COG1881	PFAM PEBP family protein
Tpen_0949	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Tpen_0950	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Tpen_0973	COG1321	iron dependent repressor
Tpen_0976	COG1918	ferrous iron import across plasma membrane
Tpen_0976	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Tpen_0985	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Tpen_0987	COG1192	Involved in chromosome partitioning
Tpen_0990	COG0393	Putative heavy-metal-binding
Tpen_0997	COG0489	protein tyrosine kinase activity
Tpen_1004	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Tpen_1009	COG0537	adenosine 5'-monophosphoramidase activity
Tpen_1013	COG0673	inositol 2-dehydrogenase activity
Tpen_1014	COG1201	RNA secondary structure unwinding
Tpen_1023	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Tpen_1026	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Tpen_1030	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Tpen_1040	COG0109	protoheme IX farnesyltransferase activity
Tpen_1041	COG2816	NAD+ diphosphatase activity
Tpen_1043	COG2814	Major facilitator Superfamily
Tpen_1044	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Tpen_1046	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
Tpen_1052	COG1254	Belongs to the acylphosphatase family
Tpen_1055	COG2182	Extracellular solute-binding protein
Tpen_1056	COG1175	transmembrane transport
Tpen_1057	COG3833	ABC-type maltose transport systems, permease component
Tpen_1059	COG0573	inorganic phosphate transmembrane transporter activity
Tpen_1060	COG0581	inorganic phosphate transmembrane transporter activity
Tpen_1064	COG0516	GMP reductase activity
Tpen_1064	COG0517	IMP dehydrogenase activity
Tpen_1069	COG0704	Plays a role in the regulation of phosphate uptake
Tpen_1070	COG3260	NADH ubiquinone oxidoreductase 20
Tpen_1071	COG0649	NAD binding
Tpen_1071	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tpen_1073	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Tpen_1076	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Tpen_1077	COG0651	ATP synthesis coupled electron transport
Tpen_1079	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tpen_1080	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tpen_1081	COG0649	NAD binding
Tpen_1085	COG0713	ATP synthesis coupled electron transport
Tpen_1087	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Tpen_1088	COG1007	ATP synthesis coupled electron transport
Tpen_1089	COG0174	glutamine synthetase
Tpen_1090	COG4821	SIS domain
Tpen_1091	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tpen_1092	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Tpen_1094	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Tpen_1098	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tpen_1100	COG3716	PTS system mannose fructose sorbose family IID component
Tpen_1102	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Tpen_1105	COG1122	ATPase activity
Tpen_1110	COG2723	6-phospho-beta-galactosidase activity
Tpen_1112	COG1085	galactose-1-phosphate uridylyltransferase
Tpen_1114	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Tpen_1119	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Tpen_1122	COG0437	4 iron, 4 sulfur cluster binding
Tpen_1127	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Tpen_1134	COG2431	L-lysine efflux transmembrane transporter activity
Tpen_1136	COG1131	(ABC) transporter
Tpen_1140	COG0017	Asparaginyl-tRNA synthetase
Tpen_1141	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Tpen_1147	COG0284	orotidine-5'-phosphate decarboxylase activity
Tpen_1148	COG0284	orotidine-5'-phosphate decarboxylase activity
Tpen_1148	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Tpen_1149	COG3842	ATPase activity
Tpen_1150	COG3833	ABC-type maltose transport systems, permease component
Tpen_1155	COG1554	hydrolase, family 65, central catalytic
Tpen_1157	COG0540	Belongs to the ATCase OTCase family
Tpen_1158	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
Tpen_1159	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Tpen_1160	COG0543	2 iron, 2 sulfur cluster binding
Tpen_1161	COG0167	dihydroorotate dehydrogenase activity
Tpen_1162	COG1418	mRNA catabolic process
Tpen_1163	COG0504	CTP synthase activity
Tpen_1165	COG3842	ATPase activity
Tpen_1168	COG1305	Transglutaminase-like
Tpen_1172	COG1131	(ABC) transporter
Tpen_1176	COG3833	ABC-type maltose transport systems, permease component
Tpen_1179	COG1575	Belongs to the MenA family. Type 1 subfamily
Tpen_1180	COG0535	radical SAM domain protein
Tpen_1185	COG2095	MarC family integral membrane protein
Tpen_1193	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Tpen_1196	COG0531	amino acid
Tpen_1199	COG0644	oxidoreductase
Tpen_1205	COG0396	ATPase activity
Tpen_1212	COG5012	cobalamin binding
Tpen_1218	COG0501	Belongs to the peptidase M48B family
Tpen_1222	COG1131	(ABC) transporter
Tpen_1228	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tpen_1231	COG0371	Dehydrogenase
Tpen_1233	COG0546	phosphoglycolate phosphatase activity
Tpen_1236	COG0864	Transcriptional regulator
Tpen_1237	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Tpen_1241	COG0698	ribose 5-phosphate isomerase
Tpen_1246	COG0601	transmembrane transport
Tpen_1248	COG0444	Belongs to the ABC transporter superfamily
Tpen_1249	COG4608	Belongs to the ABC transporter superfamily
Tpen_1250	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Tpen_1250	COG1213	nucleotidyl transferase
Tpen_1256	COG1175	transmembrane transport
Tpen_1258	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Tpen_1262	COG1373	ATPase (AAA superfamily
Tpen_1265	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
Tpen_1268	COG0037	tRNA processing
Tpen_1271	COG1234	tRNA 3'-trailer cleavage
Tpen_1273	COG1131	(ABC) transporter
Tpen_1333	COG1131	(ABC) transporter
Tpen_1344	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Tpen_1350	COG1473	amidohydrolase
Tpen_1352	COG1201	RNA secondary structure unwinding
Tpen_1372	COG0277	FAD linked oxidase domain protein
Tpen_1373	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Tpen_1375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Tpen_1376	COG1546	Belongs to the CinA family
Tpen_1376	COG1058	Belongs to the CinA family
Tpen_1382	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Tpen_1387	COG2267	carboxylic ester hydrolase activity
Tpen_1395	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Tpen_1400	COG1131	(ABC) transporter
Tpen_1403	COG1136	(ABC) transporter
Tpen_1403	COG0577	efflux transmembrane transporter activity
Tpen_1404	COG1136	(ABC) transporter
Tpen_1409	COG0437	4 iron, 4 sulfur cluster binding
Tpen_1419	COG1131	(ABC) transporter
Tpen_1425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Tpen_1427	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Tpen_1430	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Tpen_1444	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Tpen_1445	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Tpen_1445	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Tpen_1451	COG3833	ABC-type maltose transport systems, permease component
Tpen_1452	COG1175	transmembrane transport
Tpen_1455	COG1013	pyruvate-flavodoxin oxidoreductase activity
Tpen_1457	COG1773	rubredoxin
Tpen_1462	COG1131	(ABC) transporter
Tpen_1465	COG0235	Class ii aldolase
Tpen_1468	COG5012	cobalamin binding
Tpen_1479	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Tpen_1484	COG0598	Magnesium transport protein CorA
Tpen_1488	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Tpen_1488	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Tpen_1491	COG1268	BioY protein
Tpen_1492	COG0668	transmembrane transport
Tpen_1493	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Tpen_1511	COG1486	melibiose metabolic process
Tpen_1528	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tpen_1530	COG0396	ATPase activity
Tpen_1531	COG1372	Participates in initiation and elongation during chromosome replication
Tpen_1531	COG0719	Fe-S assembly protein
Tpen_1533	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Tpen_1534	COG4720	Psort location CytoplasmicMembrane, score
Tpen_1535	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Tpen_1537	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Tpen_1541	COG1122	ATPase activity
Tpen_1544	COG1122	ATPase activity
Tpen_1545	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Tpen_1553	COG3842	ATPase activity
Tpen_1564	COG0471	metal ion transport
Tpen_1566	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Tpen_1567	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
Tpen_1570	COG0450	alkyl hydroperoxide reductase
Tpen_1574	COG0419	ATPase involved in DNA repair
Tpen_1575	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Tpen_1579	COG0411	ABC transporter
Tpen_1581	COG0584	glycerophosphoryl diester phosphodiesterase
Tpen_1586	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
Tpen_1588	COG1653	transport
Tpen_1589	COG1175	transmembrane transport
Tpen_1590	COG0395	ABC-type sugar transport system, permease component
Tpen_1592	COG0438	transferase activity, transferring glycosyl groups
Tpen_1599	COG2211	Major facilitator Superfamily
Tpen_1606	COG1592	Rubrerythrin
Tpen_1611	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tpen_1615	COG0409	Hydrogenase expression formation protein
Tpen_1616	COG1070	Carbohydrate kinase
Tpen_1617	COG0395	ABC-type sugar transport system, permease component
Tpen_1618	COG1175	transmembrane transport
Tpen_1620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Tpen_1622	COG1070	Carbohydrate kinase
Tpen_1623	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Tpen_1630	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
Tpen_1631	COG0243	molybdopterin cofactor binding
Tpen_1634	COG4608	Belongs to the ABC transporter superfamily
Tpen_1635	COG0444	Belongs to the ABC transporter superfamily
Tpen_1636	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Tpen_1637	COG0601	transmembrane transport
Tpen_1638	COG0747	negative chemotaxis
Tpen_1640	COG0531	amino acid
Tpen_1641	COG0477	Major facilitator Superfamily
Tpen_1642	COG2095	MarC family integral membrane protein
Tpen_1645	COG0805	protein transport
Tpen_1647	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Tpen_1647	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Tpen_1648	COG1830	Aldolase
Tpen_1649	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Tpen_1652	COG0778	Nitroreductase
Tpen_1653	COG2814	Major facilitator Superfamily
Tpen_1653	COG0477	Major facilitator Superfamily
Tpen_1666	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Tpen_1667	COG0709	Synthesizes selenophosphate from selenide and ATP
Tpen_1670	COG0667	Aldo Keto reductase
Tpen_1677	COG0601	transmembrane transport
Tpen_1679	COG0444	Belongs to the ABC transporter superfamily
Tpen_1680	COG4608	Belongs to the ABC transporter superfamily
Tpen_1683	COG0477	Major facilitator Superfamily
Tpen_1712	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
Tpen_1714	COG1404	Belongs to the peptidase S8 family
Tpen_1719	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Tpen_1720	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Tpen_1723	COG0438	transferase activity, transferring glycosyl groups
Tpen_1726	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Tpen_1730	COG1215	transferase activity, transferring glycosyl groups
Tpen_1742	COG1122	ATPase activity
Tpen_1744	COG0438	transferase activity, transferring glycosyl groups
Tpen_1746	COG0438	transferase activity, transferring glycosyl groups
Tpen_1750	COG0714	Associated with various cellular activities
Tpen_1760	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Tpen_1760	COG0731	radical SAM domain protein
Tpen_1762	COG0513	Belongs to the DEAD box helicase family
Tpen_1763	COG1342	Belongs to the UPF0251 family
Tpen_1766	COG0493	'glutamate synthase
Tpen_1772	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Tpen_1772	COG0301	tRNA thio-modification
Tpen_1775	COG1136	(ABC) transporter
Tpen_1776	COG4591	ABC-type transport system involved in lipoprotein release permease component
Tpen_1787	COG1067	ATP-dependent peptidase activity
Tpen_1787	COG0470	DNA polymerase III
Tpen_1791	COG2094	Belongs to the DNA glycosylase MPG family
Tpen_1803	COG0425	Belongs to the sulfur carrier protein TusA family
Tpen_1806	COG3842	ATPase activity
Tpen_1813	COG0009	L-threonylcarbamoyladenylate synthase
Tpen_1820	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Tpen_1821	COG1028	Short-chain dehydrogenase reductase Sdr
Tpen_1822	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Tpen_1830	COG2033	superoxide reductase activity
Tpen_1833	COG0017	Asparaginyl-tRNA synthetase
Tpen_1837	COG4948	Mandelate Racemase Muconate Lactonizing
Tpen_1839	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Tpen_1875	COG0556	nucleotide-excision repair
Tpen_1891	COG4974	Belongs to the 'phage' integrase family