locus-tag	class	description
MA03_00025	COG0417	DNA replication proofreading
MA03_00050	COG0459	protein refolding
MA03_00085	COG0423	glycine-tRNA ligase activity
MA03_00095	COG0085	RNA polymerase activity
MA03_00100	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MA03_00130	COG0200	Binds to the 23S rRNA
MA03_00140	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MA03_00155	COG0052	Belongs to the universal ribosomal protein uS2 family
MA03_00160	COG1355	regulation of microtubule-based process
MA03_00165	COG1304	FMN binding
MA03_00185	COG0049	tRNA binding
MA03_00190	COG2255	four-way junction helicase activity
MA03_00195	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
MA03_00195	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MA03_00210	COG4948	Mandelate Racemase Muconate Lactonizing
MA03_00225	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MA03_00235	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MA03_00300	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MA03_00320	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MA03_00325	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MA03_00345	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MA03_00375	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MA03_00385	COG0089	rRNA binding
MA03_00390	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MA03_00395	COG1252	NADH dehydrogenase
MA03_00405	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MA03_00410	COG0081	regulation of translation
MA03_00420	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MA03_00430	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MA03_00435	COG0430	RNA-3'-phosphate cyclase activity
MA03_00460	COG1121	(ABC) transporter
MA03_00475	COG2379	hydroxypyruvate reductase
MA03_00535	COG0714	Associated with various cellular activities
MA03_00550	COG0563	adenylate kinase activity
MA03_00575	COG0549	Belongs to the carbamate kinase family
MA03_00585	COG2414	aldehyde ferredoxin oxidoreductase
MA03_00600	COG0746	molybdenum cofactor guanylyltransferase activity
MA03_00610	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
MA03_00610	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MA03_00620	COG1980	fructose-bisphosphate aldolase activity
MA03_00625	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MA03_00630	COG0003	Pfam Anion-transporting ATPase
MA03_00640	COG1522	sequence-specific DNA binding
MA03_00655	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MA03_00665	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MA03_00695	COG0601	transmembrane transport
MA03_00705	COG0444	Belongs to the ABC transporter superfamily
MA03_00710	COG4608	Belongs to the ABC transporter superfamily
MA03_00740	COG0444	Belongs to the ABC transporter superfamily
MA03_00745	COG4608	Belongs to the ABC transporter superfamily
MA03_00780	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MA03_00790	COG0717	Belongs to the dCTP deaminase family
MA03_00795	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MA03_00815	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MA03_00825	COG0805	protein transport
MA03_00845	COG0813	purine-nucleoside phosphorylase activity
MA03_00855	COG0864	Transcriptional regulator
MA03_00875	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MA03_00880	COG0439	Biotin carboxylase
MA03_00885	COG0084	hydrolase, TatD family'
MA03_00905	COG0644	oxidoreductase
MA03_00910	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MA03_00915	COG0148	phosphopyruvate hydratase activity
MA03_00925	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MA03_00950	COG4974	Belongs to the 'phage' integrase family
MA03_00955	COG1335	isochorismatase
MA03_00965	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MA03_00965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MA03_01005	COG2414	aldehyde ferredoxin oxidoreductase
MA03_01040	COG1546	Belongs to the CinA family
MA03_01040	COG1058	Belongs to the CinA family
MA03_01055	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MA03_01120	COG1032	radical SAM domain protein
MA03_01140	COG4172	Belongs to the ABC transporter superfamily
MA03_01165	COG0813	purine-nucleoside phosphorylase activity
MA03_01175	COG0813	purine-nucleoside phosphorylase activity
MA03_01180	COG0402	S-adenosylhomocysteine deaminase activity
MA03_01215	COG0667	Aldo Keto reductase
MA03_01225	COG0531	amino acid
MA03_01255	COG0312	modulator of DNA gyrase
MA03_01260	COG0312	modulator of DNA gyrase
MA03_01340	COG4720	Psort location CytoplasmicMembrane, score
MA03_01350	COG0129	dihydroxy-acid dehydratase activity
MA03_01370	COG3613	nucleoside 2-deoxyribosyltransferase
MA03_01410	COG2814	Major facilitator Superfamily
MA03_01425	COG1363	Peptidase, m42
MA03_01435	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MA03_01440	COG0671	phosphoesterase, PA-phosphatase related
MA03_01475	COG2033	superoxide reductase activity
MA03_01480	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MA03_01525	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MA03_01540	COG1489	DNA binding
MA03_01560	COG0009	L-threonylcarbamoyladenylate synthase
MA03_01570	COG0450	alkyl hydroperoxide reductase
MA03_01595	COG0698	ribose 5-phosphate isomerase
MA03_01615	COG1653	transport
MA03_01620	COG1175	transmembrane transport
MA03_01625	COG0395	ABC-type sugar transport system, permease component
MA03_01635	COG0438	transferase activity, transferring glycosyl groups
MA03_01655	COG0437	4 iron, 4 sulfur cluster binding
MA03_01660	COG0243	molybdopterin cofactor binding
MA03_01660	COG3383	formate dehydrogenase (NAD+) activity
MA03_01670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MA03_01680	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MA03_01720	COG0470	DNA polymerase III
MA03_01720	COG1067	ATP-dependent peptidase activity
MA03_01735	COG0778	Nitroreductase
MA03_01750	COG1136	(ABC) transporter
MA03_01755	COG4591	ABC-type transport system involved in lipoprotein release permease component
MA03_01760	COG1122	ATPase activity
MA03_01765	COG1122	ATPase activity
MA03_01795	COG0277	FAD linked oxidase domain protein
MA03_01810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MA03_01825	COG0668	transmembrane transport
MA03_01845	COG0017	Asparaginyl-tRNA synthetase
MA03_01855	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MA03_01875	COG2414	aldehyde ferredoxin oxidoreductase
MA03_01880	COG1028	Short-chain dehydrogenase reductase Sdr
MA03_01920	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
MA03_01960	COG1131	(ABC) transporter
MA03_01975	COG0577	efflux transmembrane transporter activity
MA03_01975	COG1136	(ABC) transporter
MA03_01980	COG1136	(ABC) transporter
MA03_01990	COG0409	Hydrogenase expression formation protein
MA03_01995	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MA03_02000	COG0456	acetyltransferase
MA03_02040	COG0243	molybdopterin cofactor binding
MA03_02065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MA03_02075	COG0402	S-adenosylhomocysteine deaminase activity
MA03_02095	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MA03_02095	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MA03_02100	COG0534	Mate efflux family protein
MA03_02155	COG3842	ATPase activity
MA03_02175	COG0531	amino acid
MA03_02190	COG0425	Belongs to the sulfur carrier protein TusA family
MA03_02205	COG1063	alcohol dehydrogenase
MA03_02210	COG1830	Aldolase
MA03_02225	COG1505	serine-type exopeptidase activity
MA03_02255	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MA03_02260	COG0730	response to heat
MA03_02305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MA03_02330	COG2094	Belongs to the DNA glycosylase MPG family
MA03_02370	COG0471	metal ion transport
MA03_02375	COG3842	ATPase activity
MA03_02380	COG1177	transmembrane transport
MA03_02390	COG1840	ABC-type Fe3 transport system, periplasmic component
MA03_02420	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
MA03_02455	COG0438	transferase activity, transferring glycosyl groups
MA03_02485	COG2894	cell division
MA03_02490	COG0489	protein tyrosine kinase activity
MA03_02500	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MA03_02535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MA03_02540	COG1120	ATPase activity
MA03_02560	COG3842	ATPase activity
MA03_02570	COG1175	transmembrane transport
MA03_02600	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MA03_02600	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MA03_02610	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MA03_02650	COG4608	Belongs to the ABC transporter superfamily
MA03_02655	COG0444	Belongs to the ABC transporter superfamily
MA03_02660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MA03_02665	COG0601	transmembrane transport
MA03_02670	COG0747	negative chemotaxis
MA03_02675	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
MA03_02680	COG1230	cation diffusion facilitator family transporter
MA03_02685	COG3842	ATPase activity
MA03_02690	COG0395	ABC-type sugar transport system, permease component
MA03_02695	COG1175	transmembrane transport
MA03_02735	COG1012	belongs to the aldehyde dehydrogenase family
MA03_02890	COG1203	CRISPR-associated helicase, Cas3
MA03_02990	COG1192	Involved in chromosome partitioning
MA03_03015	COG1404	Belongs to the peptidase S8 family
MA03_03020	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MA03_03045	COG5012	cobalamin binding
MA03_03080	COG1131	(ABC) transporter
MA03_03095	COG0517	IMP dehydrogenase activity
MA03_03095	COG0516	GMP reductase activity
MA03_03140	COG0805	protein transport
MA03_03170	COG1122	ATPase activity
MA03_03175	COG0109	protoheme IX farnesyltransferase activity
MA03_03180	COG0308	aminopeptidase N
MA03_03185	COG0383	alpha-mannosidase activity
MA03_03195	COG1063	alcohol dehydrogenase
MA03_03250	COG2095	MarC family integral membrane protein
MA03_03285	COG3301	Polysulphide reductase, NrfD
MA03_03290	COG0437	4 iron, 4 sulfur cluster binding
MA03_03295	COG0243	molybdopterin cofactor binding
MA03_03325	COG3285	dna ligase
MA03_03325	COG1793	dna ligase
MA03_03330	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
MA03_03350	COG0235	Class ii aldolase
MA03_03355	COG2211	Major facilitator Superfamily
MA03_03365	COG1132	(ABC) transporter
MA03_03375	COG0395	ABC-type sugar transport system, permease component
MA03_03380	COG1175	transmembrane transport
MA03_03385	COG1653	transport
MA03_03395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MA03_03410	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MA03_03455	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MA03_03475	COG2226	methyltransferase
MA03_03480	COG0535	radical SAM domain protein
MA03_03490	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MA03_03505	COG0494	nUDIX hydrolase
MA03_03600	COG2211	Major facilitator Superfamily
MA03_03620	COG1850	ribulose-bisphosphate carboxylase activity
MA03_03625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MA03_03630	COG1486	melibiose metabolic process
MA03_03645	COG1260	myo-inositol-1-phosphate synthase
MA03_03650	COG1418	mRNA catabolic process
MA03_03675	COG0535	radical SAM domain protein
MA03_03685	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MA03_03740	COG1528	Iron-storage protein
MA03_03855	COG3842	ATPase activity
MA03_03860	COG3833	ABC-type maltose transport systems, permease component
MA03_03880	COG1131	(ABC) transporter
MA03_03910	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MA03_03915	COG0393	Putative heavy-metal-binding
MA03_03935	COG0437	4 iron, 4 sulfur cluster binding
MA03_03940	COG0243	molybdopterin cofactor binding
MA03_03975	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
MA03_03980	COG0540	Belongs to the ATCase OTCase family
MA03_03985	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MA03_04005	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MA03_04010	COG0167	dihydroorotate dehydrogenase activity
MA03_04015	COG1013	pyruvate-flavodoxin oxidoreductase activity
MA03_04020	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MA03_04020	COG0674	pyruvate-flavodoxin oxidoreductase activity
MA03_04035	COG2217	Heavy metal translocating P-type atpase
MA03_04040	COG0504	CTP synthase activity
MA03_04050	COG3842	ATPase activity
MA03_04080	COG1131	(ABC) transporter
MA03_04090	COG2431	L-lysine efflux transmembrane transporter activity
MA03_04095	COG4221	oxidoreductase activity
MA03_04105	COG0586	Pfam SNARE associated Golgi protein
MA03_04125	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MA03_04160	COG1918	ferrous iron import across plasma membrane
MA03_04160	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MA03_04185	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MA03_04200	COG2723	6-phospho-beta-galactosidase activity
MA03_04220	COG1122	ATPase activity
MA03_04235	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MA03_04245	COG3716	PTS system mannose fructose sorbose family IID component
MA03_04265	COG0673	inositol 2-dehydrogenase activity
MA03_04275	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MA03_04290	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MA03_04295	COG4821	SIS domain
MA03_04300	COG1007	ATP synthesis coupled electron transport
MA03_04310	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MA03_04315	COG0713	ATP synthesis coupled electron transport
MA03_04330	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MA03_04335	COG0649	NAD binding
MA03_04340	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MA03_04345	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MA03_04355	COG0651	ATP synthesis coupled electron transport
MA03_04375	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MA03_04390	COG3260	NADH ubiquinone oxidoreductase 20
MA03_04415	COG0516	GMP reductase activity
MA03_04415	COG0517	IMP dehydrogenase activity
MA03_04425	COG0519	Catalyzes the synthesis of GMP from XMP
MA03_04425	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MA03_04430	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MA03_04445	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MA03_04445	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MA03_04450	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MA03_04455	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MA03_04465	COG0573	inorganic phosphate transmembrane transporter activity
MA03_04475	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MA03_04480	COG0303	'Molybdopterin
MA03_04490	COG1254	Belongs to the acylphosphatase family
MA03_04510	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
MA03_04520	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MA03_04525	COG2814	Major facilitator Superfamily
MA03_04535	COG0109	protoheme IX farnesyltransferase activity
MA03_04545	COG0310	cobalt ion transport
MA03_04560	COG1122	ATPase activity
MA03_04590	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MA03_04610	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MA03_04635	COG0673	inositol 2-dehydrogenase activity
MA03_04640	COG1201	RNA secondary structure unwinding
MA03_04700	COG5012	cobalamin binding
MA03_04730	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MA03_04755	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MA03_04770	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MA03_04775	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MA03_04780	COG0656	L-ascorbic acid biosynthetic process
MA03_04790	COG1122	ATPase activity
MA03_04795	COG1122	ATPase activity
MA03_04800	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MA03_04810	COG2239	Acts as a magnesium transporter
MA03_04840	COG0674	pyruvate-flavodoxin oxidoreductase activity
MA03_04840	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MA03_04845	COG1013	pyruvate-flavodoxin oxidoreductase activity
MA03_04860	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
MA03_04865	COG0501	Belongs to the peptidase M48B family
MA03_04895	COG0017	Asparaginyl-tRNA synthetase
MA03_04905	COG1201	RNA secondary structure unwinding
MA03_04925	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MA03_04935	COG1201	RNA secondary structure unwinding
MA03_04970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MA03_05055	COG1940	carbohydrate kinase activity
MA03_05060	COG0215	cysteine-tRNA ligase activity
MA03_05070	COG1126	abc transporter atp-binding protein
MA03_05090	COG0489	protein tyrosine kinase activity
MA03_05100	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
MA03_05115	COG3842	ATPase activity
MA03_05130	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MA03_05225	COG2151	metal-sulfur cluster biosynthetic enzyme
MA03_05240	COG1702	phosphate starvation-inducible protein PhoH
MA03_05280	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MA03_05290	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MA03_05295	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MA03_05305	COG1063	alcohol dehydrogenase
MA03_05310	COG1082	Xylose isomerase domain protein TIM barrel
MA03_05320	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MA03_05335	COG0442	prolyl-tRNA aminoacylation
MA03_05340	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MA03_05345	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
MA03_05400	COG0330	HflC and HflK could
MA03_05420	COG1830	Aldolase
MA03_05460	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MA03_05465	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MA03_05485	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MA03_05530	COG2835	tetraacyldisaccharide 4'-kinase activity
MA03_05535	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MA03_05615	COG1573	uracil-dna glycosylase
MA03_05640	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MA03_05650	COG0297	glycogen (starch) synthase activity
MA03_05655	COG1449	Belongs to the glycosyl hydrolase 57 family
MA03_05695	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MA03_05700	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MA03_05705	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MA03_05710	COG0183	Belongs to the thiolase family
MA03_05725	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MA03_05750	COG0126	phosphoglycerate kinase activity
MA03_05770	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MA03_05785	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MA03_05790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MA03_05800	COG1793	dna ligase
MA03_05810	COG2078	PFAM AMMECR1 domain protein
MA03_05910	COG0051	transcription antitermination factor activity, RNA binding
MA03_05915	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MA03_05920	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MA03_05930	COG0017	Asparaginyl-tRNA synthetase
MA03_05950	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
MA03_06005	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MA03_06010	COG0124	histidyl-tRNA synthetase
MA03_06015	COG2222	sugar isomerase
MA03_06020	COG1801	Protein of unknown function DUF72
MA03_06025	COG1515	deoxyribonuclease V activity
MA03_06035	COG0024	Methionine aminopeptidase
MA03_06050	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MA03_06050	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MA03_06085	COG1234	tRNA 3'-trailer cleavage
MA03_06125	COG0673	inositol 2-dehydrogenase activity
MA03_06135	COG0644	oxidoreductase
MA03_06180	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
MA03_06265	COG0395	ABC-type sugar transport system, permease component
MA03_06270	COG1175	transmembrane transport
MA03_06295	COG5002	protein histidine kinase activity
MA03_06405	COG0585	pseudouridine synthase activity
MA03_06420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MA03_06445	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
MA03_06470	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MA03_06480	COG1122	ATPase activity
MA03_06485	COG0012	GTP binding
MA03_06515	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MA03_06525	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MA03_06530	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MA03_06540	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MA03_06550	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MA03_06570	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MA03_06580	COG0142	geranyltranstransferase activity
MA03_06590	COG0432	Pfam Uncharacterised protein family UPF0047
MA03_06595	COG0045	succinate-CoA ligase (ADP-forming) activity
MA03_06595	COG1042	CoA-binding domain protein
MA03_06595	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MA03_06610	COG3842	ATPase activity
MA03_06625	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MA03_06640	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
MA03_06660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MA03_06660	COG0574	Belongs to the PEP-utilizing enzyme family
MA03_06710	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MA03_06730	COG1522	sequence-specific DNA binding
MA03_06735	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MA03_06820	COG0426	domain, Protein
MA03_06820	COG1773	rubredoxin
MA03_06825	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MA03_06850	COG0023	Translation Initiation Factor
MA03_06855	COG1013	pyruvate-flavodoxin oxidoreductase activity
MA03_06860	COG0674	pyruvate-flavodoxin oxidoreductase activity
MA03_06950	COG0419	ATPase involved in DNA repair
MA03_06970	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MA03_06990	COG2264	protein methyltransferase activity
MA03_07020	COG0045	succinate-CoA ligase (ADP-forming) activity
MA03_07030	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MA03_07035	COG0071	Belongs to the small heat shock protein (HSP20) family
MA03_07050	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MA03_07090	COG0018	arginyl-trna synthetase
MA03_07205	COG1475	DNA binding
MA03_07345	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MA03_07395	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MA03_07400	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MA03_07405	COG0255	Belongs to the universal ribosomal protein uL29 family
MA03_07415	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MA03_07420	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MA03_07435	COG0180	Tryptophanyl-tRNA synthetase
MA03_07495	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MA03_07565	COG0438	transferase activity, transferring glycosyl groups
MA03_07565	COG0297	glycogen (starch) synthase activity
MA03_07635	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MA03_07660	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MA03_07665	COG1144	Oxidoreductase
MA03_07670	COG0674	pyruvate-flavodoxin oxidoreductase activity
MA03_07675	COG1013	pyruvate-flavodoxin oxidoreductase activity
MA03_07680	COG1110	DNA topoisomerase II activity
MA03_07685	COG1051	belongs to the nudix hydrolase family
MA03_07685	COG1056	cytidyltransferase-related domain
MA03_07720	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MA03_07725	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MA03_07745	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MA03_07745	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MA03_07775	COG1028	Short-chain dehydrogenase reductase Sdr
MA03_07780	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MA03_07790	COG1078	dGTPase activity
MA03_07795	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MA03_07800	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MA03_07845	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MA03_07845	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MA03_07890	COG0552	protein localization to endoplasmic reticulum
MA03_07895	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MA03_08045	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MA03_08050	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MA03_08075	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MA03_08115	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MA03_08155	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MA03_08235	COG0501	Belongs to the peptidase M48B family
MA03_08255	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
MA03_08260	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
MA03_08280	COG1269	ATP hydrolysis coupled proton transport
MA03_08290	COG1328	CTP reductase activity
MA03_08310	COG0301	tRNA thio-modification
MA03_08310	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MA03_08335	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
MA03_08350	COG0525	valine-tRNA ligase activity
MA03_08365	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MA03_08415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MA03_08425	COG0315	cyclic pyranopterin monophosphate synthase activity
MA03_08440	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MA03_08445	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MA03_08450	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MA03_08460	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins