locus-tag	class	description
KNN16_00005	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KNN16_00015	COG0039	L-malate dehydrogenase activity
KNN16_00035	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KNN16_00050	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KNN16_00055	COG0022	dehydrogenase e1 component
KNN16_00070	COG3608	succinylglutamate desuccinylase aspartoacylase
KNN16_00070	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
KNN16_00090	COG1063	alcohol dehydrogenase
KNN16_00105	COG0778	Nitroreductase
KNN16_00110	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KNN16_00110	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KNN16_00120	COG2022	thiamine diphosphate biosynthetic process
KNN16_00120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KNN16_00130	COG2022	thiamine diphosphate biosynthetic process
KNN16_00135	COG0352	thiamine-phosphate diphosphorylase activity
KNN16_00140	COG0424	maF-like protein
KNN16_00170	COG1765	OsmC-like protein
KNN16_00180	COG1937	Protein conserved in bacteria
KNN16_00215	COG5002	protein histidine kinase activity
KNN16_00220	COG0745	RESPONSE REGULATOR receiver
KNN16_00225	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KNN16_00245	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KNN16_00265	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KNN16_00270	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KNN16_00275	COG0509	glycine decarboxylation via glycine cleavage system
KNN16_00285	COG1216	Glycosyl transferase, family 2
KNN16_00290	COG2226	methyltransferase
KNN16_00295	COG2897	thiosulfate sulfurtransferase activity
KNN16_00315	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KNN16_00320	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KNN16_00325	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KNN16_00330	COG0649	NAD binding
KNN16_00335	COG2267	carboxylic ester hydrolase activity
KNN16_00370	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
KNN16_00375	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KNN16_00385	COG0713	ATP synthesis coupled electron transport
KNN16_00400	COG1007	ATP synthesis coupled electron transport
KNN16_00405	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KNN16_00410	COG0228	four-way junction DNA binding
KNN16_00415	COG1837	Belongs to the UPF0109 family
KNN16_00420	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KNN16_00425	COG0745	RESPONSE REGULATOR receiver
KNN16_00430	COG2348	transferase activity, transferring amino-acyl groups
KNN16_00440	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KNN16_00445	COG4585	Histidine kinase
KNN16_00460	COG1597	lipid kinase activity
KNN16_00460	COG1803	Methylglyoxal synthase
KNN16_00470	COG0784	Response regulator, receiver
KNN16_00470	COG2198	Histidine kinase
KNN16_00470	COG2205	protein histidine kinase activity
KNN16_00475	COG0728	peptidoglycan biosynthetic process
KNN16_00500	COG0803	Belongs to the bacterial solute-binding protein 9 family
KNN16_00505	COG1121	(ABC) transporter
KNN16_00510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KNN16_00515	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KNN16_00540	COG2264	protein methyltransferase activity
KNN16_00545	COG0484	heat shock protein binding
KNN16_00550	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KNN16_00555	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KNN16_00560	COG0022	dehydrogenase e1 component
KNN16_00565	COG0508	dehydrogenase complex catalyzes the overall conversion of
KNN16_00580	COG0471	metal ion transport
KNN16_00580	COG3273	potassium ion transport
KNN16_00585	COG2949	membrane
KNN16_00595	COG0049	tRNA binding
KNN16_00600	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KNN16_00605	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KNN16_00610	COG0051	transcription antitermination factor activity, RNA binding
KNN16_00615	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KNN16_00620	COG0088	Forms part of the polypeptide exit tunnel
KNN16_00625	COG0089	rRNA binding
KNN16_00630	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KNN16_00635	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KNN16_00645	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KNN16_00650	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KNN16_00660	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KNN16_00665	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KNN16_00675	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KNN16_00680	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KNN16_00690	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KNN16_00695	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KNN16_00705	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KNN16_00710	COG1841	ribosomal large subunit assembly
KNN16_00715	COG0200	Binds to the 23S rRNA
KNN16_00725	COG0563	adenylate kinase activity
KNN16_00735	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KNN16_00740	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KNN16_00745	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KNN16_00750	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KNN16_00755	COG0202	RNA polymerase activity
KNN16_00760	COG0203	ribosomal protein L17
KNN16_00765	COG0101	tRNA pseudouridine synthase activity
KNN16_00770	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KNN16_00780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KNN16_00780	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KNN16_00790	COG0483	inositol monophosphate 1-phosphatase activity
KNN16_00795	COG1278	Cold shock
KNN16_00810	COG3396	Phenylacetate-CoA oxygenase
KNN16_00825	COG2151	metal-sulfur cluster biosynthetic enzyme
KNN16_00835	COG0697	spore germination
KNN16_00840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KNN16_00845	COG1573	uracil-dna glycosylase
KNN16_00855	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KNN16_00880	COG0543	2 iron, 2 sulfur cluster binding
KNN16_00915	COG0285	dihydrofolate synthase activity
KNN16_00920	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KNN16_00930	COG0463	Glycosyl transferase, family 2
KNN16_00930	COG1216	Glycosyl transferase, family 2
KNN16_00945	COG0438	transferase activity, transferring glycosyl groups
KNN16_00960	COG0438	transferase activity, transferring glycosyl groups
KNN16_01020	COG0438	transferase activity, transferring glycosyl groups
KNN16_01025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KNN16_01030	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KNN16_01035	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KNN16_01080	COG0463	Glycosyl transferase, family 2
KNN16_01095	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KNN16_01105	COG0426	domain, Protein
KNN16_01105	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KNN16_01110	COG0148	phosphopyruvate hydratase activity
KNN16_01115	COG1307	EDD domain protein, DegV family
KNN16_01145	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KNN16_01150	COG0495	leucyl-tRNA aminoacylation
KNN16_01160	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KNN16_01175	COG0822	iron-sulfur transferase activity
KNN16_01180	COG1028	Short-chain dehydrogenase reductase Sdr
KNN16_01185	COG0012	GTP binding
KNN16_01195	COG3872	metal-dependent enzyme
KNN16_01200	COG0419	ATPase involved in DNA repair
KNN16_01200	COG0419	ATPase involved in DNA repair
KNN16_01220	COG0156	8-amino-7-oxononanoate synthase activity
KNN16_01250	COG1024	Enoyl-CoA hydratase
KNN16_01265	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KNN16_01270	COG1489	DNA binding
KNN16_01275	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KNN16_01285	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KNN16_01290	COG0335	large ribosomal subunit rRNA binding
KNN16_01295	COG0606	chelatase, subunit chli
KNN16_01305	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KNN16_01330	COG0515	serine threonine protein kinase
KNN16_01330	COG2815	serine threonine protein kinase
KNN16_01335	COG1090	epimerase
KNN16_01345	COG0481	GTPase activity
KNN16_01405	COG1598	PFAM Uncharacterised protein family UPF0150
KNN16_01440	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KNN16_01445	COG0662	Cupin 2, conserved barrel domain protein
KNN16_01445	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
KNN16_01450	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KNN16_01480	COG0475	glutathione-regulated potassium exporter activity
KNN16_01485	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KNN16_01500	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KNN16_01505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KNN16_01535	COG2204	response regulator
KNN16_01545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KNN16_01550	COG0785	Cytochrome C biogenesis protein
KNN16_01560	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KNN16_01565	COG4133	protoheme IX ABC transporter activity
KNN16_01585	COG3088	subunit of a heme lyase
KNN16_01605	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
KNN16_01615	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KNN16_01615	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KNN16_01640	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KNN16_01645	COG1994	Peptidase M50
KNN16_01660	COG1181	Belongs to the D-alanine--D-alanine ligase family
KNN16_01665	COG1181	Belongs to the D-alanine--D-alanine ligase family
KNN16_01675	COG1181	Belongs to the D-alanine--D-alanine ligase family
KNN16_01705	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KNN16_01710	COG0484	heat shock protein binding
KNN16_01715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KNN16_01725	COG0789	Transcriptional regulator
KNN16_01735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KNN16_01740	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KNN16_01760	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KNN16_01760	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KNN16_01775	COG2313	pseudouridylate synthase activity
KNN16_01780	COG1570	exodeoxyribonuclease VII activity
KNN16_01785	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KNN16_01790	COG1012	belongs to the aldehyde dehydrogenase family
KNN16_01790	COG2030	dehydratase
KNN16_01795	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KNN16_01795	COG0674	pyruvate-flavodoxin oxidoreductase activity
KNN16_01800	COG1013	pyruvate-flavodoxin oxidoreductase activity
KNN16_01820	COG1215	transferase activity, transferring glycosyl groups
KNN16_01825	COG1162	GTPase activity
KNN16_01840	COG0438	transferase activity, transferring glycosyl groups
KNN16_01880	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KNN16_01885	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KNN16_01890	COG0138	bifunctional purine biosynthesis protein purh
KNN16_01905	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KNN16_01910	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KNN16_01925	COG2414	aldehyde ferredoxin oxidoreductase
KNN16_01935	COG1061	Type III restriction enzyme res subunit
KNN16_01960	COG1408	metallophosphoesterase
KNN16_01965	COG1496	oxidoreductase activity
KNN16_01970	COG1063	alcohol dehydrogenase
KNN16_01975	COG2001	Belongs to the MraZ family
KNN16_01980	COG0275	rRNA processing
KNN16_01990	COG0768	penicillin binding
KNN16_01995	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KNN16_02000	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KNN16_02005	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KNN16_02010	COG0772	Belongs to the SEDS family
KNN16_02015	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KNN16_02025	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KNN16_02030	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KNN16_02035	COG1181	Belongs to the D-alanine--D-alanine ligase family
KNN16_02050	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KNN16_02065	COG1316	TRANSCRIPTIONal
KNN16_02070	COG1196	nuclear chromosome segregation
KNN16_02105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KNN16_02110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KNN16_02115	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KNN16_02150	COG0768	penicillin binding
KNN16_02165	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KNN16_02175	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
KNN16_02175	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KNN16_02185	COG0515	serine threonine protein kinase
KNN16_02190	COG0631	protein serine/threonine phosphatase activity
KNN16_02195	COG0484	heat shock protein binding
KNN16_02200	COG1716	ATPase activity
KNN16_02210	COG0745	RESPONSE REGULATOR receiver
KNN16_02230	COG0318	PFAM AMP-dependent synthetase and ligase
KNN16_02245	COG1028	Short-chain dehydrogenase reductase Sdr
KNN16_02260	COG1546	Belongs to the CinA family
KNN16_02260	COG1058	Belongs to the CinA family
KNN16_02275	COG2723	6-phospho-beta-galactosidase activity
KNN16_02290	COG0584	glycerophosphoryl diester phosphodiesterase
KNN16_02295	COG2222	sugar isomerase
KNN16_02310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KNN16_02335	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KNN16_02350	COG2442	InterPro IPR007367
KNN16_02360	COG0470	DNA polymerase III
KNN16_02375	COG0316	Belongs to the HesB IscA family
KNN16_02380	COG0072	phenylalanine-tRNA ligase activity
KNN16_02380	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KNN16_02390	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KNN16_02400	COG4566	intracellular signal transduction
KNN16_02410	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KNN16_02420	COG0305	Participates in initiation and elongation during chromosome replication
KNN16_02430	COG2986	histidine ammonia-lyase
KNN16_02435	COG2205	protein histidine kinase activity
KNN16_02450	COG0460	homoserine dehydrogenase
KNN16_02520	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
KNN16_02550	COG0242	peptide deformylase activity
KNN16_02555	COG0574	Belongs to the PEP-utilizing enzyme family
KNN16_02555	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KNN16_02560	COG0343	queuine tRNA-ribosyltransferase activity
KNN16_02575	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KNN16_02580	COG2205	protein histidine kinase activity
KNN16_02585	COG1349	DNA-binding transcription factor activity
KNN16_02595	COG1129	ABC transporter
KNN16_02605	COG1172	Belongs to the binding-protein-dependent transport system permease family
KNN16_02615	COG4952	isomerase
KNN16_02620	COG3347	Dehydrogenase
KNN16_02620	COG1028	Short-chain dehydrogenase reductase Sdr
KNN16_02625	COG1070	Carbohydrate kinase
KNN16_02630	COG1139	Iron-sulfur cluster binding protein
KNN16_02640	COG0247	lactate metabolic process
KNN16_02670	COG0730	response to heat
KNN16_02685	COG2133	pyrroloquinoline quinone binding
KNN16_02695	COG1595	DNA-templated transcription, initiation
KNN16_02720	COG0508	dehydrogenase complex catalyzes the overall conversion of
KNN16_02720	COG0022	dehydrogenase e1 component
KNN16_02725	COG0508	dehydrogenase complex catalyzes the overall conversion of
KNN16_02735	COG3414	Phosphotransferase system galactitol-specific IIB component
KNN16_02740	COG3775	system Galactitol-specific IIC component
KNN16_02745	COG0662	Cupin 2, conserved barrel domain protein
KNN16_02770	COG0662	Cupin 2, conserved barrel domain protein
KNN16_02775	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KNN16_02785	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KNN16_02790	COG0456	acetyltransferase
KNN16_02800	COG1428	Deoxynucleoside kinase
KNN16_02805	COG1028	Short-chain dehydrogenase reductase Sdr
KNN16_02815	COG0745	RESPONSE REGULATOR receiver
KNN16_02845	COG4143	(ABC) transporter
KNN16_02925	COG2414	aldehyde ferredoxin oxidoreductase
KNN16_02930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KNN16_02950	COG0215	cysteine-tRNA ligase activity
KNN16_02960	COG4956	integral membrane protein (PIN domain superfamily)
KNN16_02965	COG2226	methyltransferase
KNN16_02970	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KNN16_02985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KNN16_02990	COG2226	methyltransferase
KNN16_03000	COG1597	lipid kinase activity
KNN16_03005	COG0556	nucleotide-excision repair
KNN16_03010	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
KNN16_03020	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KNN16_03025	COG3383	formate dehydrogenase (NAD+) activity
KNN16_03045	COG0612	Peptidase, M16
KNN16_03060	COG2217	Heavy metal translocating P-type atpase
KNN16_03070	COG0542	response to heat
KNN16_03090	COG0525	valine-tRNA ligase activity
KNN16_03095	COG0071	Belongs to the small heat shock protein (HSP20) family
KNN16_03100	COG2414	aldehyde ferredoxin oxidoreductase
KNN16_03125	COG5002	protein histidine kinase activity
KNN16_03130	COG0745	RESPONSE REGULATOR receiver
KNN16_03140	COG3191	aminopeptidase activity
KNN16_03155	COG5002	protein histidine kinase activity
KNN16_03170	COG2217	Heavy metal translocating P-type atpase
KNN16_03185	COG0003	Pfam Anion-transporting ATPase
KNN16_03190	COG0003	Pfam Anion-transporting ATPase
KNN16_03195	COG0067	glutamate synthase
KNN16_03195	COG0069	glutamate synthase activity
KNN16_03195	COG0070	glutamate synthase
KNN16_03200	COG0745	RESPONSE REGULATOR receiver
KNN16_03205	COG5002	protein histidine kinase activity
KNN16_03250	COG0577	efflux transmembrane transporter activity
KNN16_03250	COG1136	(ABC) transporter
KNN16_03255	COG0577	efflux transmembrane transporter activity
KNN16_03255	COG1136	(ABC) transporter
KNN16_03260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KNN16_03260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KNN16_03265	COG1309	transcriptional regulator
KNN16_03315	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KNN16_03320	COG0674	pyruvate-flavodoxin oxidoreductase activity
KNN16_03320	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KNN16_03325	COG1013	pyruvate-flavodoxin oxidoreductase activity
KNN16_03335	COG0443	Heat shock 70 kDa protein
KNN16_03340	COG2823	Periplasmic or secreted lipoprotein
KNN16_03345	COG0071	Belongs to the small heat shock protein (HSP20) family
KNN16_03355	COG0459	protein refolding
KNN16_03385	COG0742	ribosomal rna small subunit methyltransferase
KNN16_03405	COG2076	Multidrug Resistance protein
KNN16_03425	COG0745	RESPONSE REGULATOR receiver
KNN16_03435	COG3206	protein involved in exopolysaccharide biosynthesis
KNN16_03435	COG0489	protein tyrosine kinase activity
KNN16_03445	COG0438	transferase activity, transferring glycosyl groups
KNN16_03500	COG0247	lactate metabolic process
KNN16_03510	COG1774	PSP1 C-terminal conserved region
KNN16_03530	COG0793	Belongs to the peptidase S41A family
KNN16_03560	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KNN16_03565	COG1175	transmembrane transport
KNN16_03570	COG0395	ABC-type sugar transport system, permease component
KNN16_03590	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KNN16_03595	COG1618	nucleotide phosphatase activity, acting on free nucleotides
KNN16_03625	COG1337	RAMP superfamily
KNN16_03635	COG1353	crispr-associated protein
KNN16_03650	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KNN16_03660	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KNN16_03660	COG2080	2 iron, 2 sulfur cluster binding
KNN16_03665	COG1131	(ABC) transporter
KNN16_03675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KNN16_03680	COG1304	FMN binding
KNN16_03690	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KNN16_03695	COG1063	alcohol dehydrogenase
KNN16_03705	COG1268	BioY protein
KNN16_03710	COG0045	succinate-CoA ligase (ADP-forming) activity
KNN16_03710	COG1042	CoA-binding domain protein
KNN16_03710	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KNN16_03715	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KNN16_03725	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KNN16_03740	COG0745	RESPONSE REGULATOR receiver
KNN16_03750	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KNN16_03755	COG0745	RESPONSE REGULATOR receiver
KNN16_03760	COG1058	Belongs to the CinA family
KNN16_03760	COG1546	Belongs to the CinA family
KNN16_03770	COG1012	belongs to the aldehyde dehydrogenase family
KNN16_03775	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
KNN16_03780	COG1058	Belongs to the CinA family
KNN16_03780	COG1546	Belongs to the CinA family
KNN16_03805	COG1252	NADH dehydrogenase
KNN16_03810	COG3189	MarR family transcriptional regulator
KNN16_03855	COG1378	Sugar-specific transcriptional regulator TrmB
KNN16_03870	COG2084	Dehydrogenase
KNN16_03895	COG1082	Xylose isomerase domain protein TIM barrel
KNN16_03900	COG1028	Short-chain dehydrogenase reductase Sdr
KNN16_03905	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
KNN16_03910	COG1070	Carbohydrate kinase
KNN16_03930	COG1402	creatininase
KNN16_03935	COG1063	alcohol dehydrogenase
KNN16_03940	COG1063	alcohol dehydrogenase
KNN16_03950	COG1172	Belongs to the binding-protein-dependent transport system permease family
KNN16_03960	COG1609	Transcriptional regulator
KNN16_03965	COG0277	FAD linked oxidase domain protein
KNN16_03970	COG1216	Glycosyl transferase, family 2
KNN16_03980	COG1914	H( )-stimulated, divalent metal cation uptake system
KNN16_03985	COG2205	protein histidine kinase activity
KNN16_04005	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KNN16_04015	COG0839	Belongs to the complex I subunit 6 family
KNN16_04025	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KNN16_04045	COG1007	ATP synthesis coupled electron transport
KNN16_04065	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KNN16_04100	COG0045	succinate-CoA ligase (ADP-forming) activity
KNN16_04110	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
KNN16_04115	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KNN16_04125	COG1363	Peptidase, m42
KNN16_04130	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KNN16_04150	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KNN16_04160	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KNN16_04165	COG1077	Cell shape determining protein MreB Mrl
KNN16_04175	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
KNN16_04185	COG0538	isocitrate dehydrogenase activity
KNN16_04190	COG1012	belongs to the aldehyde dehydrogenase family
KNN16_04195	COG2975	iron-sulfur cluster assembly
KNN16_04200	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KNN16_04205	COG0649	NAD binding
KNN16_04220	COG0489	protein tyrosine kinase activity
KNN16_04235	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KNN16_04240	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KNN16_04250	COG0505	Belongs to the CarA family
KNN16_04255	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KNN16_04270	COG0842	Transport permease protein
KNN16_04275	COG1131	(ABC) transporter
KNN16_04280	COG1131	(ABC) transporter
KNN16_04285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KNN16_04290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KNN16_04300	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KNN16_04310	COG0501	Belongs to the peptidase M48B family
KNN16_04315	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KNN16_04330	COG0463	Glycosyl transferase, family 2
KNN16_04345	COG2226	methyltransferase
KNN16_04365	COG0543	2 iron, 2 sulfur cluster binding
KNN16_04380	COG0309	Hydrogenase expression formation protein (HypE)
KNN16_04400	COG0298	carbon dioxide binding
KNN16_04405	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
KNN16_04415	COG0375	protein maturation
KNN16_04440	COG0363	glucosamine-6-phosphate deaminase activity
KNN16_04445	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KNN16_04485	COG4274	PFAM GYD family protein
KNN16_04490	COG3591	Belongs to the peptidase S1B family
KNN16_04495	COG0737	Belongs to the 5'-nucleotidase family
KNN16_04510	COG1793	dna ligase
KNN16_04535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KNN16_04545	COG0330	HflC and HflK could
KNN16_04565	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KNN16_04570	COG1077	Cell shape determining protein MreB Mrl
KNN16_04585	COG0768	penicillin binding
KNN16_04590	COG0506	proline dehydrogenase activity
KNN16_04615	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KNN16_04635	COG0463	Glycosyl transferase, family 2
KNN16_04645	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
KNN16_04650	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
KNN16_04675	COG2373	Large extracellular alpha-helical protein
KNN16_04685	COG0668	transmembrane transport
KNN16_04700	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KNN16_04740	COG2205	protein histidine kinase activity
KNN16_04745	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
KNN16_04820	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KNN16_04840	COG1609	Transcriptional regulator
KNN16_04855	COG1175	transmembrane transport
KNN16_04860	COG0395	ABC-type sugar transport system, permease component
KNN16_04900	COG0235	Class ii aldolase
KNN16_04905	COG0574	Belongs to the PEP-utilizing enzyme family
KNN16_04905	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KNN16_04920	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KNN16_04930	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KNN16_04935	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KNN16_04945	COG4974	Belongs to the 'phage' integrase family
KNN16_04960	COG2003	Belongs to the UPF0758 family
KNN16_04985	COG0277	FAD linked oxidase domain protein
KNN16_04990	COG0022	dehydrogenase e1 component
KNN16_04995	COG0352	thiamine-phosphate diphosphorylase activity
KNN16_05000	COG0351	phosphomethylpyrimidine kinase
KNN16_05000	COG0352	thiamine-phosphate diphosphorylase activity
KNN16_05010	COG1028	Short-chain dehydrogenase reductase Sdr
KNN16_05015	COG1070	Carbohydrate kinase
KNN16_05030	COG1653	transport
KNN16_05040	COG1176	ABC-type spermidine putrescine transport system, permease component I
KNN16_05060	COG0434	BtpA family
KNN16_05065	COG1349	DNA-binding transcription factor activity
KNN16_05080	COG0215	cysteine-tRNA ligase activity
KNN16_05100	COG0395	ABC-type sugar transport system, permease component
KNN16_05150	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KNN16_05155	COG0105	UTP biosynthetic process
KNN16_05160	COG3345	alpha-galactosidase
KNN16_05175	COG1744	ABC transporter substrate-binding protein PnrA-like
KNN16_05185	COG2210	Belongs to the sulfur carrier protein TusA family
KNN16_05200	COG0247	lactate metabolic process
KNN16_05240	COG0564	pseudouridine synthase activity
KNN16_05260	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KNN16_05265	COG0745	RESPONSE REGULATOR receiver
KNN16_05270	COG5002	protein histidine kinase activity
KNN16_05285	COG0698	ribose 5-phosphate isomerase
KNN16_05305	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KNN16_05310	COG3794	PFAM blue (type 1) copper domain protein
KNN16_05315	COG0538	isocitrate dehydrogenase activity
KNN16_05320	COG1573	uracil-dna glycosylase
KNN16_05340	COG2135	peptidase activity
KNN16_05365	COG0542	response to heat
KNN16_05390	COG3608	succinylglutamate desuccinylase aspartoacylase
KNN16_05390	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
KNN16_05400	COG0628	permease
KNN16_05425	COG1307	EDD domain protein, DegV family
KNN16_05430	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KNN16_05435	COG1881	PFAM PEBP family protein
KNN16_05440	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KNN16_05445	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KNN16_05475	COG1192	Involved in chromosome partitioning
KNN16_05485	COG2197	response regulator
KNN16_05490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KNN16_05495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KNN16_05500	COG0438	transferase activity, transferring glycosyl groups
KNN16_05520	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KNN16_05525	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KNN16_05530	COG0277	FAD linked oxidase domain protein
KNN16_05535	COG0277	FAD linked oxidase domain protein
KNN16_05560	COG0247	lactate metabolic process
KNN16_05590	COG0438	transferase activity, transferring glycosyl groups
KNN16_05600	COG0673	inositol 2-dehydrogenase activity
KNN16_05610	COG0028	Belongs to the TPP enzyme family
KNN16_05625	COG1215	transferase activity, transferring glycosyl groups
KNN16_05630	COG2076	Multidrug Resistance protein
KNN16_05635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KNN16_05655	COG0037	tRNA processing
KNN16_05675	COG1428	Deoxynucleoside kinase
KNN16_05845	COG1518	maintenance of DNA repeat elements
KNN16_05850	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
KNN16_05855	COG2814	Major facilitator Superfamily
KNN16_05915	COG1714	RDD family
KNN16_05985	COG5002	protein histidine kinase activity
KNN16_05990	COG0745	RESPONSE REGULATOR receiver
KNN16_06055	COG4274	PFAM GYD family protein
KNN16_06070	COG0745	RESPONSE REGULATOR receiver
KNN16_06075	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KNN16_06085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KNN16_06090	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KNN16_06100	COG1353	crispr-associated protein
KNN16_06100	COG0617	tRNA 3'-terminal CCA addition
KNN16_06120	COG2226	methyltransferase
KNN16_06125	COG0366	Alpha amylase catalytic
KNN16_06160	COG1070	Carbohydrate kinase
KNN16_06165	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KNN16_06170	COG1012	belongs to the aldehyde dehydrogenase family
KNN16_06185	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KNN16_06205	COG1228	amidohydrolase
KNN16_06210	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
KNN16_06220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KNN16_06240	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
KNN16_06245	COG0596	Alpha beta hydrolase
KNN16_06255	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KNN16_06265	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KNN16_06270	COG0131	Imidazoleglycerol-phosphate dehydratase
KNN16_06280	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KNN16_06285	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KNN16_06360	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KNN16_06365	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KNN16_06370	COG0151	Belongs to the GarS family
KNN16_06375	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KNN16_06380	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KNN16_06385	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KNN16_06390	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KNN16_06395	COG2268	Band 7 protein
KNN16_06405	COG0004	ammonium transporteR
KNN16_06410	COG0475	glutathione-regulated potassium exporter activity
KNN16_06415	COG0174	glutamine synthetase
KNN16_06420	COG2508	Transcriptional regulator
KNN16_06445	COG0517	IMP dehydrogenase activity
KNN16_06450	COG0314	molybdopterin synthase activity
KNN16_06455	COG0315	cyclic pyranopterin monophosphate synthase activity
KNN16_06470	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KNN16_06485	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KNN16_06510	COG0189	ligase activity
KNN16_06515	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KNN16_06520	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KNN16_06525	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KNN16_06530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KNN16_06535	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KNN16_06540	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KNN16_06550	COG0066	3-isopropylmalate dehydratase activity
KNN16_06570	COG0745	RESPONSE REGULATOR receiver
KNN16_06590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KNN16_06605	COG4585	Histidine kinase
KNN16_06615	COG0477	Major facilitator Superfamily
KNN16_06630	COG2226	methyltransferase
KNN16_06655	COG2514	catechol 2,3-dioxygenase activity
KNN16_06665	COG0346	lactoylglutathione lyase activity
KNN16_06680	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KNN16_06685	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KNN16_06700	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KNN16_06730	COG1716	ATPase activity
KNN16_06735	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KNN16_06745	COG0438	transferase activity, transferring glycosyl groups
KNN16_06760	COG1028	Short-chain dehydrogenase reductase Sdr
KNN16_06780	COG0805	protein transport
KNN16_06785	COG1663	tetraacyldisaccharide 4'-kinase activity
KNN16_06800	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KNN16_06805	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
KNN16_06805	COG3608	succinylglutamate desuccinylase aspartoacylase
KNN16_06810	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KNN16_06835	COG1234	tRNA 3'-trailer cleavage
KNN16_06850	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KNN16_06855	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KNN16_06870	COG0280	phosphate acetyltransferase
KNN16_06870	COG0281	malic enzyme
KNN16_06890	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KNN16_06895	COG2359	stage V sporulation protein S
KNN16_06900	COG0613	PHP domain protein
KNN16_06910	COG0436	Aminotransferase
KNN16_06915	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KNN16_06925	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KNN16_06935	COG2361	Protein of unknown function DUF86
KNN16_06945	COG1574	metal-dependent hydrolase with the TIM-barrel fold
KNN16_06955	COG1595	DNA-templated transcription, initiation
KNN16_06965	COG1475	DNA binding
KNN16_06970	COG1192	Involved in chromosome partitioning
KNN16_06975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KNN16_06980	COG1847	R3H domain protein
KNN16_06985	COG0706	membrane insertase activity
KNN16_06995	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
KNN16_07000	COG0594	ribonuclease P activity
KNN16_07010	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KNN16_07025	COG0745	RESPONSE REGULATOR receiver
KNN16_07040	COG0446	pyridine nucleotide-disulphide oxidoreductase
KNN16_07050	COG1131	(ABC) transporter
KNN16_07090	COG1331	Highly conserved protein containing a thioredoxin domain
KNN16_07095	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KNN16_07125	COG0542	response to heat
KNN16_07130	COG0493	'glutamate synthase
KNN16_07130	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
KNN16_07140	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
KNN16_07150	COG1555	photosystem II stabilization
KNN16_07150	COG1596	polysaccharide export
KNN16_07165	COG1185	polyribonucleotide nucleotidyltransferase activity
KNN16_07170	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KNN16_07190	COG1543	Belongs to the glycosyl hydrolase 57 family
KNN16_07215	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KNN16_07225	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
KNN16_07230	COG2050	protein possibly involved in aromatic compounds catabolism
KNN16_07235	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
KNN16_07250	COG2368	4-hydroxyphenylacetate
KNN16_07255	COG1012	belongs to the aldehyde dehydrogenase family
KNN16_07285	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KNN16_07340	COG0302	gtp cyclohydrolase
KNN16_07360	COG0124	histidyl-tRNA synthetase
KNN16_07365	COG2226	methyltransferase
KNN16_07380	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
KNN16_07380	COG1672	PFAM Archaeal ATPase
KNN16_07415	COG1053	succinate dehydrogenase
KNN16_07440	COG0297	glycogen (starch) synthase activity
KNN16_07450	COG0114	fumarate hydratase activity
KNN16_07465	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KNN16_07470	COG5002	protein histidine kinase activity
KNN16_07480	COG0653	protein targeting
KNN16_07480	COG0653	protein targeting
KNN16_07490	COG3842	ATPase activity
KNN16_07495	COG1176	ABC-type spermidine putrescine transport system, permease component I
KNN16_07505	COG1840	ABC-type Fe3 transport system, periplasmic component
KNN16_07515	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
KNN16_07550	COG1735	metal-dependent hydrolase with the TIM-barrel fold
KNN16_07555	COG0800	Aldolase
KNN16_07580	COG0411	ABC transporter
KNN16_07595	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KNN16_07610	COG1028	Short-chain dehydrogenase reductase Sdr
KNN16_07615	COG0318	PFAM AMP-dependent synthetase and ligase
KNN16_07625	COG1309	transcriptional regulator
KNN16_07635	COG2197	response regulator
KNN16_07640	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KNN16_07645	COG2224	Isocitrate lyase
KNN16_07650	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KNN16_07660	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KNN16_07685	COG0277	FAD linked oxidase domain protein
KNN16_07695	COG3938	Belongs to the proline racemase family
KNN16_07700	COG3359	exonuclease
KNN16_07705	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KNN16_07735	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KNN16_07745	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
KNN16_07750	COG1012	belongs to the aldehyde dehydrogenase family
KNN16_07765	COG0411	ABC transporter
KNN16_07770	COG4603	Belongs to the binding-protein-dependent transport system permease family
KNN16_07775	COG0559	Belongs to the binding-protein-dependent transport system permease family
KNN16_07785	COG1574	metal-dependent hydrolase with the TIM-barrel fold
KNN16_07795	COG2267	carboxylic ester hydrolase activity
KNN16_07815	COG0559	Belongs to the binding-protein-dependent transport system permease family
KNN16_07840	COG3629	intracellular signal transduction
KNN16_07870	COG2255	four-way junction helicase activity
KNN16_07880	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KNN16_07885	COG2197	response regulator
KNN16_07905	COG0243	molybdopterin cofactor binding
KNN16_07930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KNN16_07935	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KNN16_07950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KNN16_07965	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KNN16_07975	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KNN16_07985	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KNN16_07990	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KNN16_08000	COG1177	transmembrane transport
KNN16_08010	COG3842	ATPase activity
KNN16_08035	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
KNN16_08040	COG2234	aminopeptidase activity
KNN16_08075	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KNN16_08085	COG0726	polysaccharide deacetylase
KNN16_08090	COG1187	pseudouridine synthase activity
KNN16_08100	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KNN16_08125	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KNN16_08170	COG4104	PAAR repeat-containing protein
KNN16_08170	COG3209	COG3209 Rhs family protein
KNN16_08180	COG4104	PAAR repeat-containing protein
KNN16_08180	COG3209	COG3209 Rhs family protein
KNN16_08190	COG3209	COG3209 Rhs family protein
KNN16_08190	COG4104	PAAR repeat-containing protein
KNN16_08225	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KNN16_08230	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KNN16_08230	COG0140	phosphoribosyl-ATP diphosphatase activity
KNN16_08240	COG0107	imidazoleglycerol-phosphate synthase activity
KNN16_08255	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KNN16_08260	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KNN16_08265	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
KNN16_08270	COG3005	denitrification pathway
KNN16_08290	COG2048	Heterodisulfide reductase, subunit B
KNN16_08310	COG3259	Nickel-dependent hydrogenase
KNN16_08340	COG0586	Pfam SNARE associated Golgi protein
KNN16_08370	COG1381	Involved in DNA repair and RecF pathway recombination
KNN16_08380	COG1388	LysM domain
KNN16_08380	COG3942	CHAP domain
KNN16_08410	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KNN16_08410	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KNN16_08420	COG0357	Ribosomal RNA small subunit methyltransferase G
KNN16_08425	COG1921	L-seryl-tRNASec selenium transferase activity
KNN16_08465	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KNN16_08495	COG2226	methyltransferase
KNN16_08510	COG0083	homoserine kinase activity
KNN16_08515	COG0402	S-adenosylhomocysteine deaminase activity
KNN16_08520	COG0850	regulation of cytokinetic process
KNN16_08525	COG2894	cell division
KNN16_08530	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
KNN16_08535	COG0772	Belongs to the SEDS family
KNN16_08550	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KNN16_08555	COG1615	UPF0182 protein
KNN16_08570	COG0318	PFAM AMP-dependent synthetase and ligase
KNN16_08575	COG0778	Nitroreductase
KNN16_08585	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
KNN16_08590	COG1722	exodeoxyribonuclease VII activity
KNN16_08595	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KNN16_08605	COG3842	ATPase activity
KNN16_08610	COG0205	6-phosphofructokinase activity
KNN16_08615	COG0521	Mo-molybdopterin cofactor biosynthetic process
KNN16_08620	COG1227	inorganic diphosphatase activity
KNN16_08625	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KNN16_08640	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KNN16_08650	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KNN16_08655	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KNN16_08660	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KNN16_08665	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
KNN16_08710	COG0714	Associated with various cellular activities
KNN16_08725	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KNN16_08760	COG0552	protein localization to endoplasmic reticulum
KNN16_08765	COG1388	LysM domain
KNN16_08765	COG3942	CHAP domain
KNN16_08770	COG4608	Belongs to the ABC transporter superfamily
KNN16_08775	COG0444	Belongs to the ABC transporter superfamily
KNN16_08780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KNN16_08785	COG0601	transmembrane transport
KNN16_08790	COG0765	amino acid transport
KNN16_08795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KNN16_08830	COG0492	ferredoxin-NADP+ reductase activity
KNN16_08855	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
KNN16_08855	COG0778	Nitroreductase
KNN16_08860	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KNN16_08865	COG0745	RESPONSE REGULATOR receiver
KNN16_08880	COG1968	undecaprenyl-diphosphatase activity
KNN16_08890	COG0572	uridine kinase
KNN16_08905	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KNN16_08925	COG0489	protein tyrosine kinase activity
KNN16_08925	COG3206	protein involved in exopolysaccharide biosynthesis
KNN16_08945	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KNN16_08955	COG0482	sulfurtransferase activity
KNN16_08980	COG0745	RESPONSE REGULATOR receiver
KNN16_08995	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
KNN16_09000	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
KNN16_09005	COG1302	Protein conserved in bacteria
KNN16_09020	COG4478	integral membrane protein
KNN16_09025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KNN16_09050	COG1515	deoxyribonuclease V activity
KNN16_09055	COG0745	RESPONSE REGULATOR receiver
KNN16_09060	COG2154	pterin-4-alpha-carbinolamine dehydratase
KNN16_09065	COG0149	triose-phosphate isomerase activity
KNN16_09075	COG3842	ATPase activity
KNN16_09095	COG1079	Belongs to the binding-protein-dependent transport system permease family
KNN16_09100	COG4603	Belongs to the binding-protein-dependent transport system permease family
KNN16_09105	COG1129	ABC transporter
KNN16_09120	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KNN16_09120	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
KNN16_09130	COG0601	transmembrane transport
KNN16_09135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KNN16_09145	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KNN16_09185	COG0179	Fumarylacetoacetate (FAA) hydrolase
KNN16_09190	COG5002	protein histidine kinase activity
KNN16_09200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KNN16_09205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KNN16_09210	COG1254	Belongs to the acylphosphatase family
KNN16_09225	COG0717	Belongs to the dCTP deaminase family
KNN16_09245	COG1111	helicase
KNN16_09245	COG1205	dead DEAH box helicase
KNN16_09250	COG1811	Na channel or pump
KNN16_09255	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KNN16_09295	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
KNN16_09300	COG0287	Prephenate dehydrogenase
KNN16_09305	COG1122	ATPase activity
KNN16_09315	COG0310	cobalt ion transport
KNN16_09320	COG0735	belongs to the Fur family
KNN16_09330	COG2890	protein-(glutamine-N5) methyltransferase activity
KNN16_09335	COG0698	ribose 5-phosphate isomerase
KNN16_09340	COG0438	transferase activity, transferring glycosyl groups
KNN16_09355	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KNN16_09370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KNN16_09375	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KNN16_09380	COG0549	Belongs to the carbamate kinase family
KNN16_09385	COG1028	Short-chain dehydrogenase reductase Sdr
KNN16_09390	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KNN16_09395	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KNN16_09395	COG0758	DNA mediated transformation
KNN16_09405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KNN16_09410	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KNN16_09415	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KNN16_09430	COG5002	protein histidine kinase activity
KNN16_09445	COG0268	Binds directly to 16S ribosomal RNA
KNN16_09455	COG0018	arginyl-trna synthetase
KNN16_09475	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
KNN16_09490	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KNN16_09495	COG0084	hydrolase, TatD family'
KNN16_09510	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
KNN16_09525	COG0438	transferase activity, transferring glycosyl groups
KNN16_09540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KNN16_09570	COG0251	oxidation-reduction process
KNN16_09580	COG1024	Enoyl-CoA hydratase
KNN16_09590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KNN16_09610	COG5002	protein histidine kinase activity
KNN16_09615	COG0674	pyruvate-flavodoxin oxidoreductase activity
KNN16_09615	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KNN16_09615	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
KNN16_09615	COG1013	pyruvate-flavodoxin oxidoreductase activity
KNN16_09620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KNN16_09625	COG2086	electron transfer activity
KNN16_09630	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
KNN16_09635	COG0247	lactate metabolic process
KNN16_09635	COG2181	nitrate reductase activity
KNN16_09650	COG1013	pyruvate-flavodoxin oxidoreductase activity
KNN16_09655	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KNN16_09655	COG0674	pyruvate-flavodoxin oxidoreductase activity
KNN16_09665	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KNN16_09670	COG0674	pyruvate-flavodoxin oxidoreductase activity
KNN16_09675	COG1013	pyruvate-flavodoxin oxidoreductase activity
KNN16_09680	COG0517	IMP dehydrogenase activity
KNN16_09685	COG0686	Belongs to the AlaDH PNT family
KNN16_09690	COG0427	acetyl-CoA hydrolase
KNN16_09700	COG2197	response regulator
KNN16_09705	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KNN16_09710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KNN16_09720	COG0437	4 iron, 4 sulfur cluster binding
KNN16_09735	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KNN16_09740	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KNN16_09750	COG2151	metal-sulfur cluster biosynthetic enzyme
KNN16_09760	COG0396	ATPase activity
KNN16_09765	COG0719	Fe-S assembly protein
KNN16_09770	COG0719	Fe-S assembly protein
KNN16_09775	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KNN16_09780	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KNN16_09785	COG0740	serine-type endopeptidase activity
KNN16_09790	COG0544	peptidyl-prolyl cis-trans isomerase activity
KNN16_09795	COG1716	ATPase activity
KNN16_09800	COG0792	nuclease activity
KNN16_09815	COG0126	phosphoglycerate kinase activity
KNN16_09820	COG0372	Belongs to the citrate synthase family
KNN16_09835	COG0217	transcriptional regulatory protein
KNN16_09840	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
KNN16_09850	COG0632	four-way junction helicase activity
KNN16_09865	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
KNN16_09875	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KNN16_09885	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KNN16_09890	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KNN16_09905	COG0009	L-threonylcarbamoyladenylate synthase
KNN16_09930	COG0725	ABC transporter, periplasmic molybdate-binding protein
KNN16_09940	COG1316	TRANSCRIPTIONal
KNN16_09945	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KNN16_09950	COG0336	Belongs to the RNA methyltransferase TrmD family
KNN16_09955	COG1067	ATP-dependent peptidase activity
KNN16_09985	COG0438	transferase activity, transferring glycosyl groups
KNN16_10000	COG1012	belongs to the aldehyde dehydrogenase family
KNN16_10010	COG1196	nuclear chromosome segregation
KNN16_10010	COG0739	heme binding
KNN16_10010	COG0741	lytic transglycosylase activity
KNN16_10015	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KNN16_10025	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KNN16_10030	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KNN16_10035	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KNN16_10045	COG0137	argininosuccinate synthase activity
KNN16_10050	COG0165	Argininosuccinate lyase
KNN16_10055	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KNN16_10060	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KNN16_10065	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KNN16_10070	COG2909	trisaccharide binding
KNN16_10090	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KNN16_10100	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KNN16_10110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KNN16_10115	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KNN16_10120	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KNN16_10125	COG0196	riboflavin kinase activity
KNN16_10135	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KNN16_10140	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KNN16_10145	COG0438	transferase activity, transferring glycosyl groups
KNN16_10150	COG0395	ABC-type sugar transport system, permease component
KNN16_10155	COG1175	transmembrane transport
KNN16_10170	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
KNN16_10180	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KNN16_10195	COG0463	Glycosyl transferase, family 2
KNN16_10200	COG0438	transferase activity, transferring glycosyl groups
KNN16_10210	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KNN16_10225	COG0747	negative chemotaxis
KNN16_10250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KNN16_10255	COG0515	serine threonine protein kinase
KNN16_10255	COG2815	serine threonine protein kinase
KNN16_10260	COG2720	vancomycin resistance protein
KNN16_10270	COG1388	LysM domain
KNN16_10275	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
KNN16_10315	COG4555	ABC transporter
KNN16_10320	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KNN16_10340	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KNN16_10345	COG0573	inorganic phosphate transmembrane transporter activity
KNN16_10350	COG0581	inorganic phosphate transmembrane transporter activity
KNN16_10355	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KNN16_10360	COG0704	Plays a role in the regulation of phosphate uptake
KNN16_10370	COG2379	hydroxypyruvate reductase
KNN16_10375	COG0500	methyltransferase
KNN16_10395	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KNN16_10405	COG0475	glutathione-regulated potassium exporter activity
KNN16_10420	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KNN16_10425	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KNN16_10435	COG0303	'Molybdopterin
KNN16_10440	COG3033	Beta-eliminating lyase
KNN16_10450	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KNN16_10460	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KNN16_10475	COG0493	'glutamate synthase
KNN16_10475	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
KNN16_10485	COG0640	Transcriptional regulator
KNN16_10495	COG0163	prenyltransferase activity
KNN16_10510	COG2188	Transcriptional regulator
KNN16_10515	COG4821	SIS domain
KNN16_10525	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KNN16_10540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KNN16_10545	COG5002	protein histidine kinase activity
KNN16_10550	COG0745	RESPONSE REGULATOR receiver
KNN16_10565	COG1959	2 iron, 2 sulfur cluster binding
KNN16_10580	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KNN16_10610	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KNN16_10625	COG0647	UMP catabolic process
KNN16_10660	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KNN16_10670	COG1598	PFAM Uncharacterised protein family UPF0150
KNN16_10680	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KNN16_10700	COG0438	transferase activity, transferring glycosyl groups
KNN16_10710	COG0824	Thioesterase
KNN16_10715	COG0750	zinc metalloprotease
KNN16_10745	COG1136	(ABC) transporter
KNN16_10775	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KNN16_10785	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KNN16_10800	COG0629	single-stranded DNA binding
KNN16_10825	COG0237	dephospho-CoA kinase activity
KNN16_10830	COG2080	2 iron, 2 sulfur cluster binding
KNN16_10835	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KNN16_10840	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KNN16_10845	COG0321	lipoyl(octanoyl) transferase activity
KNN16_10850	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KNN16_10915	COG1136	(ABC) transporter
KNN16_10920	COG0577	efflux transmembrane transporter activity
KNN16_10920	COG1136	(ABC) transporter
KNN16_10935	COG5002	protein histidine kinase activity
KNN16_10955	COG0745	RESPONSE REGULATOR receiver
KNN16_10960	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KNN16_10965	COG1121	(ABC) transporter
KNN16_10970	COG0803	Belongs to the bacterial solute-binding protein 9 family
KNN16_10980	COG0497	DNA recombination
KNN16_10990	COG1836	PFAM Integral membrane protein DUF92
KNN16_10995	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KNN16_11000	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KNN16_11005	COG1063	alcohol dehydrogenase
KNN16_11010	COG0156	8-amino-7-oxononanoate synthase activity
KNN16_11035	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KNN16_11035	COG0519	Catalyzes the synthesis of GMP from XMP
KNN16_11050	COG0159	tryptophan synthase activity
KNN16_11055	COG0133	tryptophan synthase activity
KNN16_11060	COG0135	phosphoribosylanthranilate isomerase activity
KNN16_11065	COG0134	indole-3-glycerol-phosphate synthase activity
KNN16_11070	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KNN16_11075	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KNN16_11075	COG0512	Glutamine amidotransferase of anthranilate synthase
KNN16_11080	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KNN16_11085	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KNN16_11100	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
KNN16_11100	COG1672	PFAM Archaeal ATPase
KNN16_11115	COG1231	oxidoreductase activity
KNN16_11150	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KNN16_11190	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KNN16_11195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KNN16_11200	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KNN16_11205	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KNN16_11210	COG0799	negative regulation of ribosome biogenesis
KNN16_11215	COG0193	aminoacyl-tRNA hydrolase activity
KNN16_11225	COG0301	tRNA thio-modification
KNN16_11230	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KNN16_11240	COG0604	alcohol dehydrogenase
KNN16_11245	COG1960	acyl-CoA dehydrogenase activity
KNN16_11250	COG1250	3-hydroxyacyl-CoA dehydrogenase
KNN16_11280	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KNN16_11285	COG1278	Cold shock
KNN16_11290	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KNN16_11295	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KNN16_11315	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KNN16_11320	COG0017	Asparaginyl-tRNA synthetase
KNN16_11330	COG0444	Belongs to the ABC transporter superfamily
KNN16_11335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KNN16_11340	COG0601	transmembrane transport
KNN16_11370	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KNN16_11380	COG0183	Belongs to the thiolase family
KNN16_11385	COG1250	3-hydroxyacyl-CoA dehydrogenase
KNN16_11385	COG1024	Enoyl-CoA hydratase
KNN16_11390	COG0596	Alpha beta hydrolase
KNN16_11395	COG0596	Alpha beta hydrolase
KNN16_11415	COG1960	acyl-CoA dehydrogenase activity
KNN16_11420	COG1960	acyl-CoA dehydrogenase activity
KNN16_11425	COG0318	PFAM AMP-dependent synthetase and ligase
KNN16_11435	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
KNN16_11445	COG0739	heme binding
KNN16_11480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KNN16_11485	COG0601	transmembrane transport
KNN16_11490	COG4166	transmembrane transport
KNN16_11505	COG0360	Binds together with S18 to 16S ribosomal RNA
KNN16_11510	COG0629	single-stranded DNA binding
KNN16_11540	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KNN16_11545	COG2740	Nucleic-acid-binding protein implicated in transcription termination
KNN16_11555	COG0195	Participates in both transcription termination and antitermination
KNN16_11560	COG1674	ftsk spoiiie
KNN16_11580	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KNN16_11590	COG2217	Heavy metal translocating P-type atpase
KNN16_11685	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KNN16_11690	COG0232	Belongs to the dGTPase family. Type 2 subfamily
KNN16_11715	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KNN16_11730	COG1980	fructose-bisphosphate aldolase activity
KNN16_11735	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KNN16_11750	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KNN16_11755	COG0723	plastoquinol--plastocyanin reductase activity
KNN16_11775	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KNN16_11800	COG2264	protein methyltransferase activity
KNN16_11805	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KNN16_11810	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KNN16_11815	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KNN16_11830	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
KNN16_11830	COG3608	succinylglutamate desuccinylase aspartoacylase
KNN16_11835	COG2146	nitrite reductase [NAD(P)H] activity
KNN16_11850	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KNN16_11855	COG0438	transferase activity, transferring glycosyl groups
KNN16_11870	COG1193	negative regulation of DNA recombination
KNN16_11875	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KNN16_11890	COG0259	pyridoxamine-phosphate oxidase activity
KNN16_11905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KNN16_11910	COG1335	isochorismatase
KNN16_11915	COG1827	regulation of RNA biosynthetic process
KNN16_11920	COG0477	Major facilitator Superfamily
KNN16_11935	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KNN16_11950	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KNN16_11955	COG1040	competence protein
KNN16_12045	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KNN16_12050	COG0571	ribonuclease III activity
KNN16_12075	COG2813	Specifically methylates the guanine in position
KNN16_12080	COG1160	GTP binding
KNN16_12090	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KNN16_12125	COG0436	Aminotransferase
KNN16_12150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KNN16_12155	COG4608	Belongs to the ABC transporter superfamily
KNN16_12160	COG0444	Belongs to the ABC transporter superfamily
KNN16_12170	COG2094	Belongs to the DNA glycosylase MPG family
KNN16_12175	COG0134	indole-3-glycerol-phosphate synthase activity
KNN16_12185	COG0300	oxidoreductase activity
KNN16_12200	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KNN16_12210	COG0359	binds to the 23S rRNA
KNN16_12215	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KNN16_12220	COG1674	ftsk spoiiie
KNN16_12275	COG1131	(ABC) transporter
KNN16_12310	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KNN16_12355	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KNN16_12360	COG1131	(ABC) transporter
KNN16_12370	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KNN16_12375	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KNN16_12380	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KNN16_12410	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KNN16_12415	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
KNN16_12420	COG0180	Tryptophanyl-tRNA synthetase
KNN16_12440	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KNN16_12470	COG2255	four-way junction helicase activity
KNN16_12530	COG1674	ftsk spoiiie
KNN16_12545	COG0598	Magnesium transport protein CorA
KNN16_12560	COG0438	transferase activity, transferring glycosyl groups
KNN16_12600	COG3833	ABC-type maltose transport systems, permease component
KNN16_12605	COG1175	transmembrane transport
KNN16_12610	COG2182	Extracellular solute-binding protein
KNN16_12615	COG1609	Transcriptional regulator
KNN16_12645	COG1490	D-aminoacyl-tRNA deacylase activity
KNN16_12655	COG4948	Mandelate Racemase Muconate Lactonizing
KNN16_12660	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KNN16_12660	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KNN16_12665	COG0511	ligase activity, forming carbon-carbon bonds
KNN16_12665	COG5016	pyruvate
KNN16_12670	COG0439	Biotin carboxylase
KNN16_12675	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KNN16_12680	COG0322	excinuclease ABC activity
KNN16_12685	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KNN16_12695	COG1595	DNA-templated transcription, initiation
KNN16_12700	COG5002	protein histidine kinase activity
KNN16_12730	COG2267	carboxylic ester hydrolase activity
KNN16_12740	COG0762	integral membrane protein
KNN16_12745	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KNN16_12760	COG0709	Synthesizes selenophosphate from selenide and ATP
KNN16_12775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KNN16_12780	COG1172	Belongs to the binding-protein-dependent transport system permease family
KNN16_12785	COG1129	ABC transporter
KNN16_12790	COG1879	ABC-type sugar transport system periplasmic component
KNN16_12795	COG1172	Belongs to the binding-protein-dependent transport system permease family
KNN16_12800	COG1869	D-ribose catabolic process
KNN16_12805	COG1609	Transcriptional regulator
KNN16_12825	COG0438	transferase activity, transferring glycosyl groups
KNN16_12845	COG0534	Mate efflux family protein
KNN16_12850	COG1720	tRNA m6t6A37 methyltransferase activity
KNN16_12880	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KNN16_12890	COG1575	Belongs to the MenA family. Type 1 subfamily
KNN16_12920	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
KNN16_12930	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KNN16_12955	COG1920	GTP binding
KNN16_12960	COG3870	Protein conserved in bacteria
KNN16_12965	COG3870	Protein conserved in bacteria
KNN16_12995	COG1234	tRNA 3'-trailer cleavage
KNN16_13000	COG0430	RNA-3'-phosphate cyclase activity
KNN16_13025	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KNN16_13065	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KNN16_13075	COG0183	Belongs to the thiolase family
KNN16_13095	COG1253	flavin adenine dinucleotide binding
KNN16_13100	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KNN16_13115	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KNN16_13120	COG1215	transferase activity, transferring glycosyl groups
KNN16_13130	COG1305	Transglutaminase-like
KNN16_13135	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
KNN16_13155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KNN16_13160	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KNN16_13205	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KNN16_13210	COG0456	acetyltransferase
KNN16_13210	COG0454	-acetyltransferase
KNN16_13225	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KNN16_13230	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KNN16_13250	COG1247	-acetyltransferase
KNN16_13255	COG2197	response regulator
KNN16_13265	COG1940	carbohydrate kinase activity
KNN16_13270	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KNN16_13275	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KNN16_13285	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KNN16_13290	COG2137	regulation of response to DNA damage stimulus
KNN16_13295	COG1418	mRNA catabolic process
KNN16_13305	COG0612	Peptidase, M16
KNN16_13310	COG3956	TIGRFAM MazG family protein
KNN16_13320	COG0739	heme binding
KNN16_13330	COG0010	Belongs to the arginase family
KNN16_13335	COG0736	holo-[acyl-carrier-protein] synthase activity
KNN16_13345	COG1858	cytochrome C peroxidase
KNN16_13350	COG4481	Protein conserved in bacteria
KNN16_13355	COG1011	Hydrolase
KNN16_13365	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
KNN16_13375	COG0542	response to heat
KNN16_13380	COG0539	negative regulation of cytoplasmic translation
KNN16_13415	COG1131	(ABC) transporter
KNN16_13420	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KNN16_13430	COG2738	Putative neutral zinc metallopeptidase
KNN16_13435	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KNN16_13440	COG0586	Pfam SNARE associated Golgi protein
KNN16_13455	COG4412	M6 family metalloprotease domain protein
KNN16_13455	COG1404	Belongs to the peptidase S8 family
KNN16_13460	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KNN16_13470	COG0312	modulator of DNA gyrase
KNN16_13485	COG2259	Doxx family
KNN16_13490	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KNN16_13495	COG2376	Dihydroxyacetone kinase
KNN16_13500	COG1461	Dihydroxyacetone kinase
KNN16_13510	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KNN16_13530	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KNN16_13535	COG0693	protein deglycase activity
KNN16_13545	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KNN16_13565	COG0442	prolyl-tRNA aminoacylation
KNN16_13575	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
KNN16_13585	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KNN16_13600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KNN16_13610	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KNN16_13620	COG0284	orotidine-5'-phosphate decarboxylase activity
KNN16_13625	COG0167	dihydroorotate dehydrogenase activity
KNN16_13640	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KNN16_13645	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
KNN16_13650	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KNN16_13655	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KNN16_13660	COG0535	radical SAM domain protein
KNN16_13670	COG0113	porphobilinogen synthase activity
KNN16_13680	COG0181	hydroxymethylbilane synthase activity
KNN16_13685	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KNN16_13690	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
KNN16_13695	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
KNN16_13725	COG1404	Belongs to the peptidase S8 family
KNN16_13750	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KNN16_13760	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KNN16_13765	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KNN16_13775	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KNN16_13780	COG1609	Transcriptional regulator
KNN16_13795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KNN16_13800	COG0444	Belongs to the ABC transporter superfamily
KNN16_13805	COG4608	Belongs to the ABC transporter superfamily
KNN16_13815	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
KNN16_13825	COG0222	ribosome binding
KNN16_13830	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KNN16_13835	COG0081	regulation of translation
KNN16_13840	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KNN16_13850	COG0250	Participates in transcription elongation, termination and antitermination
KNN16_13865	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KNN16_13870	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KNN16_13890	COG0646	methionine synthase
KNN16_13890	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KNN16_13900	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
KNN16_13910	COG0747	negative chemotaxis
KNN16_13925	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KNN16_13930	COG0546	phosphoglycolate phosphatase activity
KNN16_13940	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KNN16_13945	COG0802	atpase or kinase
KNN16_13985	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KNN16_14000	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
KNN16_14005	COG1091	dTDP-4-dehydrorhamnose reductase activity
KNN16_14010	COG1216	Glycosyl transferase, family 2
KNN16_14020	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KNN16_14025	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KNN16_14030	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
KNN16_14030	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KNN16_14035	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KNN16_14060	COG3209	COG3209 Rhs family protein
KNN16_14060	COG4104	PAAR repeat-containing protein
KNN16_14070	COG3209	COG3209 Rhs family protein
KNN16_14070	COG4104	PAAR repeat-containing protein
KNN16_14085	COG1435	thymidine kinase activity
KNN16_14090	COG0254	rRNA binding
KNN16_14095	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KNN16_14100	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KNN16_14110	COG0483	inositol monophosphate 1-phosphatase activity
KNN16_14120	COG2205	protein histidine kinase activity
KNN16_14125	COG1705	Flagellar rod assembly protein muramidase FlgJ
KNN16_14125	COG1388	LysM domain
KNN16_14140	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KNN16_14145	COG0438	transferase activity, transferring glycosyl groups
KNN16_14155	COG2226	methyltransferase
KNN16_14185	COG1832	CoA-binding protein
KNN16_14195	COG1024	Enoyl-CoA hydratase
KNN16_14200	COG1250	3-hydroxyacyl-CoA dehydrogenase
KNN16_14205	COG1250	3-hydroxyacyl-CoA dehydrogenase
KNN16_14230	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
KNN16_14240	COG1960	acyl-CoA dehydrogenase activity
KNN16_14250	COG0129	dihydroxy-acid dehydratase activity
KNN16_14255	COG0473	3-isopropylmalate dehydrogenase activity
KNN16_14260	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KNN16_14265	COG0066	3-isopropylmalate dehydratase activity
KNN16_14275	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KNN16_14280	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KNN16_14285	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KNN16_14290	COG0440	acetolactate synthase activity
KNN16_14295	COG0028	Belongs to the TPP enzyme family
KNN16_14300	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KNN16_14305	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
KNN16_14320	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KNN16_14320	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KNN16_14330	COG0416	fatty acid biosynthetic process
KNN16_14335	COG1215	transferase activity, transferring glycosyl groups
KNN16_14340	COG0109	protoheme IX farnesyltransferase activity
KNN16_14340	COG1612	heme a metabolic process
KNN16_14345	COG0726	polysaccharide deacetylase
KNN16_14350	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KNN16_14350	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KNN16_14355	COG3845	ABC transporter
KNN16_14360	COG4603	Belongs to the binding-protein-dependent transport system permease family
KNN16_14365	COG1199	ATP-dependent helicase activity
KNN16_14365	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KNN16_14370	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KNN16_14390	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KNN16_14395	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KNN16_14400	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KNN16_14405	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KNN16_14410	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
KNN16_14415	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KNN16_14440	COG0297	glycogen (starch) synthase activity
KNN16_14445	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KNN16_14450	COG1449	Belongs to the glycosyl hydrolase 57 family
KNN16_14460	COG0438	transferase activity, transferring glycosyl groups
KNN16_14480	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
KNN16_14500	COG1609	Transcriptional regulator
KNN16_14505	COG1653	transport
KNN16_14510	COG1175	transmembrane transport
KNN16_14520	COG3842	ATPase activity
KNN16_14530	COG0383	alpha-mannosidase activity
KNN16_14545	COG0745	RESPONSE REGULATOR receiver
KNN16_14550	COG2205	protein histidine kinase activity
KNN16_14565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KNN16_14570	COG0765	amino acid transport
KNN16_14575	COG0765	amino acid transport
KNN16_14580	COG0295	cytidine deaminase activity
KNN16_14585	COG1316	TRANSCRIPTIONal
KNN16_14590	COG1960	acyl-CoA dehydrogenase activity
KNN16_14595	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KNN16_14610	COG0095	Lipoate-protein ligase
KNN16_14620	COG1355	regulation of microtubule-based process
KNN16_14650	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
KNN16_14655	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
KNN16_14670	COG0187	DNA topoisomerase II activity
KNN16_14710	COG2181	nitrate reductase activity
KNN16_14710	COG0247	lactate metabolic process
KNN16_14735	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KNN16_14745	COG0504	CTP synthase activity
KNN16_14755	COG1597	lipid kinase activity
KNN16_14770	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KNN16_14775	COG0154	amidase activity
KNN16_14785	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KNN16_14795	COG0617	tRNA 3'-terminal CCA addition
KNN16_14795	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KNN16_14795	COG3620	sequence-specific DNA binding
KNN16_14820	COG1063	alcohol dehydrogenase
KNN16_14830	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KNN16_14835	COG0575	Belongs to the CDS family
KNN16_14845	COG0233	cytoplasmic translational termination
KNN16_14850	COG0528	UMP kinase activity
KNN16_14855	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KNN16_14860	COG0052	Belongs to the universal ribosomal protein uS2 family
KNN16_14895	COG0784	Response regulator, receiver
KNN16_14895	COG2205	protein histidine kinase activity
KNN16_14895	COG5002	protein histidine kinase activity
KNN16_14910	COG0442	prolyl-tRNA aminoacylation
KNN16_14915	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KNN16_14940	COG0436	Aminotransferase
KNN16_14945	COG0494	nUDIX hydrolase
KNN16_14955	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KNN16_14980	COG0569	domain protein
KNN16_14990	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KNN16_14990	COG2010	Cytochrome c
KNN16_14995	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KNN16_15010	COG1966	Carbon starvation protein
KNN16_15020	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
KNN16_15030	COG2226	methyltransferase
KNN16_15045	COG0085	RNA polymerase activity
KNN16_15050	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KNN16_15050	COG1796	DNA polymerase